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https://www.readbyqxmd.com/read/28228180/age-related-oxidative-stress-and-antioxidant-capacity-in-heat-stressed-broilers
#1
A P Del Vesco, A S Khatlab, E S R Goes, K S Utsunomiya, J S Vieira, A R Oliveira Neto, E Gasparino
We aimed to evaluate the effects of acute heat stress (HS) and age on the redox state in broilers aged 21 and 42 days. We evaluated the expression of genes related to antioxidant capacity, the production of hydrogen peroxide (H2O2), and the activity of antioxidant enzymes in the liver, as well as oxidative stress markers in the liver and plasma. The experiment had a completely randomized factorial design with two thermal environments (thermoneutral and HS, 38°C for 24 h) and two ages (21 and 42 days). Twenty-one-day-old animals exposed to HS showed the highest thioredoxin reductase 1 (TrxR1) (P<0...
February 23, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28214375/anti-fatigue-effects-of-troxerutin-on-exercise-endurance-capacity-oxidative-stress-and-mmp-9-levels-in-trained-male-rats
#2
Mohammad Zamanian, Mohammad R Hajizadeh, Ali Esmaeili Nadimi, Ali Shamsizadeh, Mohammad Allahtavakoli
The aim of this study was to investigate effects of troxerutin (TRX) on endurance capacity, oxidative stress and MMP-9 levels in trained male rats. Forty male Wistar rats were divided into five groups. The control (Vehicle) and exercise training (5 days/week) with vehicle treatment (Exercise), exercise training with TRX treatment at 75 (Ex-TRX75), 150 (Ex-TRX150), and 300 mg/kg (Ex-TRX300). The treated groups received TRX by gavage every day while the other groups received water for 30 days. On the 30(th) day, rats were sacrificed immediately after exhaustive swimming test, and some biochemical parameters were measured...
February 18, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28192930/mitochondria-targeted-and-intracellular-biothiol-triggered-hyperpolarized-129-xe-magnetofluorescent-biosensor
#3
Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S Bouchard, Xin Zhou
Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are associated with abnormal cellular biothiol levels. Thus, the intracellular detection of biothiol levels could be a useful diagnostic tool. A number of methods have been developed to detect intracellular thiols, but sensitivity and specificity problems have limited their applications. To address these limitations, we have designed a new biosensor based on hyperpolarized xenon magnetic resonance detection, which can be used to detect biothiol levels noninvasively...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28185719/the-induction-of-oxidative-stress-in-cervix-carcinoma-cells-by-levoglucosenone-derived-4-s-salicyl-derivative-and-1-4-s-thio-disaccharides-part-4
#4
Joanna Sarnik, Anna Czubatka-Bienkowska, Anna Macieja, Roman Bielski, Zbigniew J Witczak, Tomasz Poplawski
(1-4)-S-thiodisaccharides were shown to kill various cancer cell lines, including cervix, lung, mammary-gland and colon by unknown mechanisms. Here we identified two actions of levoglucosenone derived (1-4)-S-thiodisaccharides against cervix cancer cells: induction of oxidative stress and DNA damage. In consequence, (1-4)-S-thiodisaccharides lowered the cellular GSH level and changed the expression profile of genes encoding key proteins involved with oxidative stress response. We also observed that (1-4)-S-thiodisaccharides induced DNA damage and interfered with the thioredoxin (Trx) system...
January 22, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28183062/thioredoxin-trxo1-interacts-with-proliferating-cell-nuclear-antigen-pcna-and-its-overexpression-affects-the-growth-of-tobacco-cell-culture
#5
Aingeru Calderón, Ana Ortiz-Espín, Raquel Iglesias-Fernández, Pilar Carbonero, Federico Vicente Pallardó, Francisca Sevilla, Ana Jiménez
Thioredoxins (Trxs), key components of cellular redox regulation, act by controlling the redox status of many target proteins, and have been shown to play an essential role in cell survival and growth. The presence of a Trx system in the nucleus has received little attention in plants, and the nuclear targets of plant Trxs have not been conclusively identified. Thus, very little is known about the function of Trxs in this cellular compartment. Previously, we studied the intracellular localization of PsTrxo1 and confirmed its presence in mitochondria and, interestingly, in the nucleus under standard growth conditions...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28183007/thioredoxin-and-metallothionein-homeostasis-related-proteins-in-lip-carcinogenesis
#6
Patrícia C Caldeira, Laíssa S Silva, Aline C Batista, Maria Cássia F Aguiar
OBJECTIVE: Thioredoxin (Trx) and metallothionein (MT) are involved in the development of some carcinomas; however, the role of these proteins in labial carcinogenesis has not yet been tested. The aims of the study were to evaluate and to correlate the immunoexpression of Trx and MT in actinic cheilitis, lip squamous cell carcinoma, and normal vermillion lip mucosa. DESIGN: Immunohistochemistry was undertaken for Trx and MT in samples of actinic cheilitis, lip squamous cell carcinoma, and normal lip mucosa...
February 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28179506/thioredoxin-reverses-age-related-hypertension-by-chronically-improving-vascular-redox-and-restoring-enos-function
#7
Rob H P Hilgers, Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Leon C Chen, Luis G Cuello, Nancy J Rusch, Kumuda C Das
The incidence of high blood pressure with advancing age is notably high, and it is an independent prognostic factor for the onset or progression of a variety of cardiovascular disorders. Although age-related hypertension is an established phenomenon, current treatments are only palliative but not curative. Thus, there is a critical need for a curative therapy against age-related hypertension, which could greatly decrease the incidence of cardiovascular disorders. We show that overexpression of human thioredoxin (TRX), a redox protein, in mice prevents age-related hypertension...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28178212/anti-inflammatory-activity-of-sanghuangporus-sanghuang-mycelium
#8
Wang-Ching Lin, Jeng-Shyan Deng, Shyh-Shyun Huang, Sheng-Hua Wu, Chin-Chu Chen, Wan-Rong Lin, Hui-Yi Lin, Guan-Jhong Huang
Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with lipopolysaccharides (LPS)-induced ALI in mice and to investigate its possible mechanism of action...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28168934/a-comparative-evaluation-of-3-different-free-form-deformable-image-registration-and-contour-propagation-methods-for-head-and-neck-mri
#9
Sara Broggi, Elisa Scalco, Maria Luisa Belli, Gerlinde Logghe, Dirk Verellen, Stefano Moriconi, Anna Chiara, Anna Palmisano, Renata Mellone, Claudio Fiorino, Giovanna Rizzo
PURPOSE: To validate and compare the deformable image registration and parotid contour propagation process for head and neck magnetic resonance imaging in patients treated with radiotherapy using 3 different approaches-the commercial MIM, the open-source Elastix software, and an optimized version of it. MATERIALS AND METHODS: Twelve patients with head and neck cancer previously treated with radiotherapy were considered. Deformable image registration and parotid contour propagation were evaluated by considering the magnetic resonance images acquired before and after the end of the treatment...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28168010/rutin-as-a-mediator-of-lipid-metabolism-and-cellular-signaling-pathways-interactions-in-fibroblasts-altered-by-uva-and-uvb-radiation
#10
Agnieszka Gęgotek, Paula Rybałtowska-Kawałko, Elżbieta Skrzydlewska
Background. Rutin is a natural nutraceutical that is a promising compound for the prevention of UV-induced metabolic changes in skin cells. The aim of this study was to examine the effects of rutin on redox and endocannabinoid systems, as well as proinflammatory and proapoptotic processes, in UV-irradiated fibroblasts. Methods. Fibroblasts exposed to UVA and UVB radiation were treated with rutin. The activities and levels of oxidants/antioxidants and endocannabinoid system components, as well as lipid, DNA, and protein oxidation products, and the proinflammatory and pro/antiapoptotic proteins expression were measured...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28146421/the-hdac-inhibitor-ar42-interacts-with-pazopanib-to-kill-trametinib-dabrafenib-resistant-melanoma-cells-in-vitro-and-in-vivo
#11
Laurence Booth, Jane L Roberts, Cindy Sander, John Lee, John M Kirkwood, Andrew Poklepovic, Paul Dent
Studies focused on the killing of activated B-RAF melanoma cells by the histone deacetylase (HDAC) inhibitor AR42. Compared to other tumor cell lines, PDX melanoma isolates were significantly more sensitive to AR42-induced killing. AR42 and the multi-kinase inhibitor pazopanib interacted to activate: an eIF2α-Beclin1 pathway causing autophagosome formation; an eIF2α-DR4/DR5/CD95 pathway; and an eIF2α-dependent reduction in the expression of c-FLIP-s, MCL-1 and BCL-XL. AR42 did not alter basal chaperone activity but increased the ability of pazopanib to inhibit HSP90, HSP70 and GRP78...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28142057/the-effect-of-classical-swine-fever-virus-ns5a-and-ns5a-mutants-on-oxidative-stress-and-inflammatory-response-in-swine-testicular-cells
#12
Wang Dong, Huifang Lv, Yifan Wang, Xiaomeng Li, Cheng Li, Lu Wang, Chengbao Wang, Kangkang Guo, Yanming Zhang
Infection with classical swine fever virus (CSFV) results in highly significant economic losses; this infection is characterized by being highly contagious and accompanied by hyperthermia and systemic bleeding. Oxidative stress (OS) plays a critical role in the pathological process of viral infection. The function of the nonstructural protein 5A (NS5A) in the pathogenesis of CSFV has not been completely understood. Here, OS and the inflammatory response were studied with NS5A and substitution mutants in swine testicular (ST) cells...
January 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28134858/docking-into-mycobacterium-tuberculosis-thioredoxin-reductase-protein-yields-pyrazolone-lead-molecules-for-methicillin-resistant-staphylococcus-aureus
#13
Noreena L Sweeney, Lauren Lipker, Alicia M Hanson, Chris J Bohl, Katie E Engel, Kelsey S Kalous, Mary E Stemper, Daniel S Sem, William R Schwan
The thioredoxin/thioredoxin reductase system (Trx/TrxR) is an attractive drug target because of its involvement in a number of important physiological processes, from DNA synthesis to regulating signal transduction. This study describes the finding of pyrazolone compounds that are active against Staphylococcus aureus. Initially, the project was focused on discovering small molecules that may have antibacterial properties targeting the Mycobacterium tuberculosis thioredoxin reductase. This led to the discovery of a pyrazolone scaffold-containing compound series that showed bactericidal capability against S...
January 28, 2017: Antibiotics
https://www.readbyqxmd.com/read/28132855/bone-marrow-derived-mesenchymal-stem-cells-expressing-thioredoxin-1-attenuate-bleomycin-induced-skin-fibrosis-and-oxidative-stress-in-scleroderma
#14
Miao Jiang, Yiwu Yu, Jingying Luo, Qingyun Gao, Lili Zhang, Qiangxiong Wang, Jingjun Zhao
Systemic sclerosis (SSc) is an autoimmune disorder that affects multiple organs. It is characterised by a thickening of the dermis and connective tissue caused by collagen accumulation, and vascular injuries that induce hypoxia. The present study investigated the therapeutic potential of bone marrow-derived mesenchymal stem cells (BMSCs) expressing thioredoxin 1 (Trx-1) in treating SSc-mediated skin disease following transplantation into a bleomycin-induced murine model. Mice with bleomycin-induced SSc were subcutaneously injected with BMSCs or Trx-1-overexpressing BMSCs and exposed to hypoxic conditions for 48 h...
January 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28132522/inhibition-of-nfe2l2-are-pathway-by-mitochondrial-ros-contributes-to-development-of-cardiomyopathy-and-left-ventricular-dysfunction-in-chagas-disease
#15
Jian-Jun Wen, Craig Porter, Nisha Jain Garg
AIMS: We investigated the effects of mitochondrial reactive oxygen species (mtROS) on NFE2L2 transcription factor activity during Trypanosoma cruzi (Tc) infection, and determined if enhancing the mtROS scavenging capacity preserved the heart function in Chagas disease. RESULTS: C57BL/6 wild type (WT, female) mice infected with Tc exhibited myocardial loss of mitochondrial membrane potential, complex-II driven coupled respiration, and 9-fold increase in mtROS production...
January 28, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28111273/serum-and-urinary-thioredoxin-concentrations-are-associated-with-severity-of-children-hydronephrosis
#16
Zhe-Ming Xu, Min-Ju Li, Chang Tao
BACKGROUND: Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO. METHODS: This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay...
January 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28093200/postoperative-serum-thioredoxin-concentrations-correlate-with-delirium-and-cognitive-dysfunction-after-hip-fracture-surgery-in-elderly-patients
#17
Xiao-Min Wu, Wei-Cai Xu, Yong-Jian Yu, Liang Han, Jun Zhang, Li-Jiao Yang
BACKGROUND: Oxidative stress correlates with occurrence and development of postoperative delirium (POD) and cognitive dysfunction (POCD). Thioredoxin (TRX) is a potent anti-oxidant and its circulating concentrations reflect extent of brain injury. We determined the relation of serum TRX concentrations to POD and POCD in elderly patients undergoing hip fracture surgery. METHODS: In this prospective, observatory study, TRX concentrations in preoperative and postoperative serum from 192 patients and serum from 192 controls were measured using an enzyme-linked immunosorbent assay...
March 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28087409/thioredoxin-a-novel-biomarker-of-post-injury-sepsis
#18
Jesper Eriksson, Andreas Gidlöf, Mikael Eriksson, Emma Larsson, Olof Brattström, Anders Oldner
BACKGROUND: Thioredoxin (TRX), an endogenous anti-oxidant protein induced in inflammatory conditions, has been shown to increase in plasma and to be associated with outcome in septic patients. This biomarker has never been studied in a trauma setting. We hypothesized that TRX would be increased after trauma and associated with post-injury sepsis. METHODS: Single-centre prospective observational study conducted at the intensive care unit (ICU) at the Karolinska University Hospital, Stockholm, Sweden, a level-1 trauma centre...
March 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28075401/anti-neuroblastoma-properties-of-a-recombinant-sunflower-lectin
#19
Marcela Pinedo, Melanie Genoula, María Ximena Silveyra, André De Oliveira Carvalho, Mariana Regente, Marianela Del Río, Júlia Ribeiro Soares, Valdirene Moreira Gomes, Laura De La Canal
According to their sugar recognition specificity, plant lectins are proposed as bioactive proteins with potential in cancer treatment and diagnosis. Helja is a mannose-specific jacalin-like lectin from sunflower which was shown to inhibit the growth of certain fungi. Here, we report its recombinant expression in a prokaryotic system and its activity in neurobalstoma cells. Helja coding sequence was fused to the pET-32 EK/LIC, the enterokinase/Ligation-independent cloning vector and a 35 kDa protein was obtained in Escherichia coli representing Helja coupled to thioredoxin (Trx)...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28063949/vitamin-d-supplementation-inhibits-oxidative-stress-and-upregulate-sirt1-ampk-glut4-cascade-in-high-glucose-treated-3t3l1-adipocytes-and-in-adipose-tissue-of-high-fat-diet-fed-diabetic-mice
#20
Prasenjit Manna, Arunkumar E Achari, Sushil K Jain
This study examined the hypothesis that vitamin-D prevents oxidative stress and upregulates glucose metabolism via activating insulin-independent signaling molecules in 3T3-L1 adipocytes and in high fat diet (HFD)-fed mice. To investigate the mechanism 3T3L1 adipocytes were treated with high glucose (HG, 25 mM) and 1,25(OH)2D3 (1,25-dihydroxyvitamin D3) (0-50 nM). Results showed that 1,25(OH)2D3 supplementation decreased NOX4 expression, ROS production, NF-κB phosphorylation, and increased the expression of Nrf2 and Trx in HG-treated cells...
January 4, 2017: Archives of Biochemistry and Biophysics
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