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https://www.readbyqxmd.com/read/28323828/liquid-handling-lego-robots-and-experiments-for-stem-education-and-research
#1
Lukas C Gerber, Agnes Calasanz-Kaiser, Luke Hyman, Kateryna Voitiuk, Uday Patil, Ingmar H Riedel-Kruse
Liquid-handling robots have many applications for biotechnology and the life sciences, with increasing impact on everyday life. While playful robotics such as Lego Mindstorms significantly support education initiatives in mechatronics and programming, equivalent connections to the life sciences do not currently exist. To close this gap, we developed Lego-based pipetting robots that reliably handle liquid volumes from 1 ml down to the sub-μl range and that operate on standard laboratory plasticware, such as cuvettes and multiwell plates...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28323648/patient-use-of-the-electronic-communication-portal-in-management-of-type-2-diabetes
#2
Diana Peremislov
High incidence and prevalence of type 2 diabetes require urgent attention to the management of this chronic disease. The purpose of this study was to explore electronic communication (e-communication) between patients with type 2 diabetes and their providers within the patient portal. Qualitative design with conventional content analysis techniques was used. A purposive random sample of 90 electronic medical record charts of patient-portal users with type 2 diabetes was subjected to a retrospective review. The sample mainly consisted of patients between the ages of 50 and 70 years, who were white, non- Hispanic, and English-speaking...
March 21, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28319672/extremes-in-otolaryngology-resident-surgical-case-numbers-an-update
#3
Tiffany P Baugh, Christine B Franzese
Objectives The purpose of this study is to examine the effect of minimum case numbers on otolaryngology resident case log data and understand differences in minimum, mean, and maximum among certain procedures as a follow-up to a prior study. Study Design Cross-sectional survey using a national database. Setting Academic otolaryngology residency programs. Subjects and Methods Review of otolaryngology resident national data reports from the Accreditation Council for Graduate Medical Education (ACGME) resident case log system performed from 2004 to 2015...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28319491/breaking-down-the-objective-structured-clinical-examination-an-evaluation-of-the-helping-babies-breathe-osces
#4
Teresa L Seto, Meredith E Tabangin, Kathryn K Taylor, Srirama Josyula, Juan Carlos Vasquez, Beena D Kamath-Rayne
INTRODUCTION: Helping Babies Breathe (HBB) is a simulation-based neonatal resuscitation curriculum designed for low-resource settings. At the completion of the workshop, learners complete the following four assessments: a multiple-choice question (MCQ) test, bag-mask ventilation (BMV) checklist, and two objective structured clinical examinations (OSCEs). Objective structured clinical examinations are clinical performance assessments that evaluate learners' skills in simulated scenarios...
March 18, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28315495/legumain-cleavable-4-arm-poly-ethylene-glycol-doxorubicin-conjugate-for-tumor-specific-delivery-and-release
#5
Huicong Zhou, Huanjiao Sun, Shixian Lv, Dawei Zhang, Xuefei Zhang, Zhaohui Tang, Xuesi Chen
Traditional chemotherapy strategy exists undesirable toxic side-effects to normal tissues due to the low selectively to cancer cells of micromolecule cytotoxic drugs. One considered method to realizing the targeted delivery and increasing the specificity to tumor tissues of the cytotoxic drug is to transporting and discharging it through an environment-sensitive mechanism. In this study, a novel enzyme-sensitive polymer-doxorubicin conjugate was designed to delivery chemotherapeutic drug in a tumor-specific behavior and selectively activated in tumor tissue...
March 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28315145/educational-intervention-on-undergraduate-cancer-awareness-and-self-directed-learning
#6
Lih-Lian Hwang
Traditional lecture-based learning (LBL) can increase cancer awareness in undergraduates. However, because of the rapidly changing knowledge base in medicine, undergraduates must develop skills required for lifelong self-directed learning (SDL). Problem-based learning (PBL) has been suggested as an SDL approach. This study used a nonequivalent control group with a pretest-posttest design for comparing PBL and LBL for their effectiveness in increasing cancer awareness and SDL among nonmedicine or nonnursing major undergraduates in a health-related general education course...
March 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28302921/deciphering-the-acute-cellular-phosphoproteome-response-to-irradiation-with-x-rays-protons-and-carbon-ions
#7
Martin Winter, Ivana Dokic, Julian Schlegel, Uwe Warnken, Jürgen Debus, Amir Abdollahi, Martina Schnölzer
Radiotherapy is a cornerstone of cancer therapy. The recently established particle therapy with raster-scanning protons and carbon ions landmarks a new era in the field of high-precision cancer medicine. However, molecular mechanisms governing radiation induced intracellular signaling remain elusive. Here, we present the first comprehensive proteomic and phosphoproteomic study applying stable isotope labeling by amino acids in cell culture (SILAC) in combination with high-resolution mass spectrometry to decipher cellular response to irradiation with X-rays, protons and carbon ions...
March 16, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28299771/diagrams-benefit-symbolic-problem-solving
#8
Junyi Chu, Bethany Rittle-Johnson, Emily R Fyfe
BACKGROUND: The format of a mathematics problem often influences students' problem-solving performance. For example, providing diagrams in conjunction with story problems can benefit students' understanding, choice of strategy, and accuracy on story problems. However, it remains unclear whether providing diagrams in conjunction with symbolic equations can benefit problem-solving performance as well. AIMS: We tested the impact of diagram presence on students' performance on algebra equation problems to determine whether diagrams increase problem-solving success...
March 16, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28295204/encouraging-maternal-guidance-of-preschoolers-spatial-thinking-during-block-play
#9
Giulia A Borriello, Lynn S Liben
Spatial thinking, an important component of cognition, supports academic achievement and daily activities (e.g., learning science and math; using maps). Better spatial skills are correlated with more spatial play and more parental attention to spatial concepts. Tested here was whether informing mothers about spatial thinking and ways to encourage it would increase the spatial guidance they provide to their preschool children (N = 41; M = 5.23 years) during dyadic block play. Mothers given such instructions indeed produced more spatial language and spatial guidance than mothers asked to play as usual...
March 13, 2017: Child Development
https://www.readbyqxmd.com/read/28294393/the-new-msc-mscs-as-pericytes-are-sentinels-and-gatekeepers
#10
REVIEW
Arnold I Caplan
Human Mesenchymal Stem Cells, hMSCs, were first named over 25 years ago with the "stem cell" nomenclature derived from the fact that we and others could cause these cells to differentiate into a number of different mesodermal phenotypes in cell culture. The capacity to form skeletal tissue in vitro encouraged the use of hMSCs for the fabrication of tissue engineered skeletal repair tissue with subsequent transplantation to in vivo sites. With the current realization that MSCs are derived from perivascular cells, pericytes, and the immunomodulatory and trophic capabilities of MSCs in both in vitro and in vivo test systems, a complete re-evaluation of the role and functions of MSCs in the body was required...
March 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28293754/impact-of-a-teacher-as-coach-model-improving-paraprofessionals-fidelity-of-implementation-of-discrete-trial-training-for-students-with-moderate-to-severe-developmental-disabilities
#11
Rose A Mason, Alana G Schnitz, Howard P Wills, Raia Rosenbloom, Debra M Kamps, Darcey Bast
Ensuring educational progress for students with moderate-to-severe developmental disabilities requires exposure to well executed evidence-based practices. This necessitates that the special education workforce, including paraprofessionals, be well-trained. Yet evidence regarding effective training mechanisms for paraprofessionals is limited. A multiple baseline design across five teachers was used to evaluate the impact of online instructional modules and a Practice-Based Coaching (PBC) model with teacher-as-coach on their paraprofessionals' fidelity of discrete trial training (DTT)...
March 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28292505/unintentional-methadone-and-buprenorphine-exposures-in-children-developing-prevention-messages
#12
Lauren Schwartz, Maria Mercurio-Zappala, Mary Ann Howland, Robert S Hoffman, Mark K Su
OBJECTIVES: To develop key messages for methadone and buprenorphine safety education material based on an analysis of calls to the NYC Poison Control Center (NYC PCC) and designed for distribution to caregivers of young children. METHODS: Retrospective review of all calls for children 5 years of age and younger involving methadone or buprenorphine from January 1, 2000, to June 15, 2014. A data abstraction form was completed for each case to capture patient demographics, exposure and caller sites, caller relation to patient, qualitative information regarding the exposure scenario, the product information, if naloxone was given, and the medical outcome of the case...
March 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28292304/design-and-implementation-of-electronic-health-record-integrated-clinical-prediction-rules-icpr-a-randomized-trial-in-diverse-primary-care-settings
#13
David A Feldstein, Rachel Hess, Thomas McGinn, Rebecca G Mishuris, Lauren McCullagh, Paul D Smith, Michael Flynn, Joseph Palmisano, Gheorghe Doros, Devin Mann
BACKGROUND: Clinical prediction rules (CPRs) represent a method of determining individual patient risk to help providers make more accurate decisions at the point of care. Well-validated CPRs are underutilized but may decrease antibiotic overuse for acute respiratory infections. The integrated clinical prediction rules (iCPR) study builds on a previous single clinic study to integrate two CPRs into the electronic health record and assess their impact on practice. This article discusses study design and implementation of a multicenter cluster randomized control trial of the iCPR clinical decision support system, including the tool adaptation, usability testing, staff training, and implementation study to disseminate iCPR at multiple clinical sites across two health care systems...
March 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28291926/development-of-a-deep-inspiration-breath-hold-system-for-radiotherapy-utilizing-a-laser-distance-measurer
#14
Christer Andre Jensen, Nils Skottner, Jomar Frengen, Jo-Åsmund Lund
Deep inspiration breath-hold (DIBH) is a technique for treating left-sided breast cancer (LSBC). In modern radiotherapy, one of the main aims is to exclude the heart from the beam aperture with an individualized beam design for LSBC. A deep inhalation will raise the chest wall while the volume of the lungs increase, this will again push the heart away from the breast to be treated. There are a few commercial DIBH systems, both invasive and noninvasive. We present an alternative noninvasive DIBH system based upon an industrial laser distance measurer...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291515/enhancing-behavioral-control-increases-sharing-in-children
#15
Nikolaus Steinbeis, Harriet Over
Young children endorse norms of fairness but rarely act on them. We investigated whether a failure of behavioral control can partially explain why children do not share more generously than they do. We experimentally manipulated behavioral control and observed its effects on sharing in 120 children aged 6-9years of age. Using a between-participants design, we presented children with stories in which a protagonist either exerted behavioral control in an unrelated context or not. Following this, children engaged in a sharing task...
March 10, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28290711/visualising-a-rare-and-complex-case-of-advanced-hilar-cholangiocarcinoma
#16
Jia Qu, Albert Fung, Paul Kelly, Gordon Tait, Paul D Greig, Anne Agur, Ian D McGilvray, Jodie Jenkinson
The Toronto Video Atlas of Liver, Pancreas, Biliary, and Transplant Surgery (TVASurg) is a free online library of three-dimensional (3D) animation-enhanced surgical videos, designed to instruct surgical fellows in hepato-pancreato-biliary (HPB) and transplant procedures. The video 'Klatskin tumours: Extended left hepatectomy with complex portal vein reconstruction and in situ cold perfusion of the liver', which is available to watch at http://TVASurg.ca , is a unique and valuable visual resource for surgeons in training to assist them in learning this rare procedure...
March 14, 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/28289303/an-elective-course-to-foster-interest-in-academic-pharmacy-career-opportunities
#17
Joshua J Spooner, Daniel R Kennedy
Objective. To create an elective course to foster student interest in pursuing a career in academic pharmacy. Design. The course met for two hours once weekly throughout the semester and required student attendance at the AACP Annual Meeting. The course included didactic instruction, a student-designed individual teaching seminar, design and implementation of a research project for presentation at a national meeting, and drafting of a manuscript suitable for publication in a peer-reviewed journal. Assessment...
February 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28289302/use-of-entertainment-elements-in-an-online-video-mini-series-to-train-pharmacy-preceptors
#18
Craig D Cox, Jongpil Cheon, Steven M Crooks, Jaehoon Lee, Jacob D Curtis
Objective. To create an entertaining approach to training pharmacy preceptors. Design. A training program was developed to provide an innovative, entertaining, and flexible continuing education program for pharmacy preceptors. Three instructional design principles - providing an authentic context, offering a diversity of content, and engaging and maintaining attention - were foundational to this concept. The mini-series consisted of 12 online video episodes. Participants completed three reflective questions and one evaluation after watching each episode...
February 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28288103/reproducibility-of-computational-workflows-is-automated-using-continuous-analysis
#19
Brett K Beaulieu-Jones, Casey S Greene
Replication, validation and extension of experiments are crucial for scientific progress. Computational experiments are scriptable and should be easy to reproduce. However, computational analyses are designed and run in a specific computing environment, which may be difficult or impossible to match using written instructions. We report the development of continuous analysis, a workflow that enables reproducible computational analyses. Continuous analysis combines Docker, a container technology akin to virtual machines, with continuous integration, a software development technique, to automatically rerun a computational analysis whenever updates or improvements are made to source code or data...
March 13, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28286663/knowledge-into-learning-comparing-lecture-e-learning-and-self-study-take-home-packet-instructional-methodologies%C3%A2-with-nurses
#20
Tracey Soper
AIM: The aim of this quantitative experimental study was to examine which of three instructional methodologies of traditional lecture, online electronic learning (e-learning) and self-study take-home packets are effective in knowledge acquisition of professional registered nurses. DESIGN: A true experimental design was conducted to contrast the knowledge acquisition of 87 registered nurses randomly selected. METHODS: A 40-item Acute Coronary Syndrome (ACS) true/false test was used to measure knowledge acquisition...
April 2017: Nursing Open
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