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https://www.readbyqxmd.com/read/29149506/integrating-soft-and-hard-tissues-via-interface-tissue-engineering
#1
REVIEW
Sahishnu Patel, Jon-Michael Caldwell, Stephen B Doty, William N Levine, Scott Rodeo, Louis J Soslowsky, Stavros Thomopoulos, Helen H Lu
The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal post-surgical intervention. Interface tissue engineering represents an integrative strategy for regenerating the native enthesis by functionally connecting soft and hard tissues and thereby improving clinical outcome. This review focuses on integrative and cell-instructive scaffold designs that target the healing of the two most commonly injured soft tissue-bone junctions: the tendon-bone interface (e...
November 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29149077/rna-virus-evolution-via-a-quasispecies-based-model-reveals-a-drug-target-with-a-high-barrier-to-resistance
#2
Richard J Bingham, Eric C Dykeman, Reidun Twarock
The rapid occurrence of therapy-resistant mutant strains provides a challenge for anti-viral therapy. An ideal drug target would be a highly conserved molecular feature in the viral life cycle, such as the packaging signals in the genomes of RNA viruses that encode an instruction manual for their efficient assembly. The ubiquity of this assembly code in RNA viruses, including major human pathogens, suggests that it confers selective advantages. However, their impact on viral evolution cannot be assessed in current models of viral infection that lack molecular details of virus assembly...
November 17, 2017: Viruses
https://www.readbyqxmd.com/read/29145468/the-effects-of-non-surgical-periodontal-treatment-on-glycemic-control-oxidative-stress-balance-and-quality-of-life-in-patients-with-type-2-diabetes-a-randomized-clinical-trial
#3
Hirofumi Mizuno, Daisuke Ekuni, Takayuki Maruyama, Kota Kataoka, Toshiki Yoneda, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Jun Wada, Manabu Morita
AIM: The purpose of this study was to investigate the effects of non-surgical periodontal treatment on hemoglobinA1c (HbA1c) levels, oxidative stress balance and quality of life (QOL) in patients with type 2 diabetes mellitus (T2DM) compared to no periodontal treatment (simple oral hygiene instructions only). METHODS: The design was a 6-month, single-masked, single center, randomized clinical trial. Patients had both T2DM and chronic periodontitis. Forty participants were enrolled between April 2014 and March 2016 at the Nephrology, Diabetology and Endocrinology Department of Okayama University Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/29141445/measurement-of-dabigatran-previously-demonstrated-hemoclot-%C3%A2-thrombin-inhibitor-assay-reagent-instability-on-sysmex-cs-2100i-is-no-longer-an-issue
#4
Willemijn J Comuth, Louise Faaborg, Linda Ø Henriksen, Anna-Marie B Münster
The Hemoclot(®) Thrombin Inhibitor (HTI) assay has been recommended for measurement of dabigatran concentrations in specific clinical situations. Traditionally, reagents for biochemical assays are prepared from instructions found in the package insert. For the HTI reagents the manufacturer recommends incubating the reagents much longer than indicated in the package insert. These recommendations are added to the application sheets designed for different analyzers. Many clinicians and laboratory personnel may be unaware of the discrepancy between the two instructions, resulting in incorrect handling of the reagents...
November 16, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29140818/drop-instillation-and-glaucoma
#5
Scott A Davis, Betsy Sleath, Delesha M Carpenter, Susan J Blalock, Kelly W Muir, Donald L Budenz
PURPOSE OF REVIEW: To describe the current state of knowledge regarding glaucoma patients' eye drop technique, interventions attempting to improve eye drop technique, and methods for assessing eye drop technique. RECENT FINDINGS: In observational studies, between 18.2 and 80% of patients contaminate their eye drop bottle by touching their eye or face, 11.3-60.6% do not instill exactly one drop, and 6.8-37.3% miss the eye with the drop. Factors significantly associated with poorer technique include older age, lack of instruction on eye drop technique, female sex, arthritis, more severe visual field defect, lack of positive reinforcement to take eye drops, lower educational level, low self-efficacy, and being seen at a clinic rather than a private practice...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29137725/a-gait-retraining-system-using-augmented-reality-to-modify-footprint-parameters-effects-on-lower-limb-sagittal-plane-kinematics
#6
Sami Bennour, Baptiste Ulrich, Thomas Legrand, Brigitte M Jolles, Julien Favre
Improving lower-limb flexion/extension angles during walking is important for the treatment of numerous pathologies. Currently, these gait retraining procedures are mostly qualitative, often based on visual assessment and oral instructions. This study aimed to propose an alternative method combining motion capture and display of target footprints on the floor. The second objectives were to determine the error in footprint modifications and the effects of footprint modifications on lower-limb flexion/extension angles...
November 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29137721/current-robotic-curricula-for-surgery-residents-a-need-for-additional-cognitive-and-psychomotor-focus
#7
Courtney A Green, Hueylan Chern, Patricia S O'Sullivan
BACKGROUND: Current robot surgery curricula developed by industry were designed for expert surgeons. We sought to identify the robotic curricula that currently exist in general surgery residencies and describe their components. METHODS: We identified 12 residency programs with robotic curricula. Using a structured coding form to identify themes including sequence, duration, emphasis and assessment, we generated a descriptive summary. RESULTS: Curricula followed a similar sequence: learners started with online modules and simulation exercises, followed by bedside experience during R2-R3 training years, and then operative opportunities on the console in the final years of training...
November 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29137659/the-effectiveness-of-research-implementation-strategies-for-promoting-evidence-informed-policy-and-management-decisions-in-healthcare-a-systematic-review
#8
REVIEW
Mitchell N Sarkies, Kelly-Ann Bowles, Elizabeth H Skinner, Romi Haas, Haylee Lane, Terry P Haines
BACKGROUND: It is widely acknowledged that health policy and management decisions rarely reflect research evidence. Therefore, it is important to determine how to improve evidence-informed decision-making. The primary aim of this systematic review was to evaluate the effectiveness of research implementation strategies for promoting evidence-informed policy and management decisions in healthcare. The secondary aim of the review was to describe factors perceived to be associated with effective strategies and the inter-relationship between these factors...
November 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29135589/safety-and-effectiveness-of-a-novel-facemask-for-positive-pressure-ventilation
#9
Tod A Brown, Tamas A Szabo, Kathryn H Bridges, Michel J Sabbagh, William R Hand, Bethany J Wolf, Robert D Warters
BACKGROUND: Manual positive pressure ventilation is an essential skill in a variety of clinical situations. The C&E technique is commonly used with standard facemasks to provide effective ventilation. The Tao mask is a novel design that allows a more ergonomic grip. A seal between the mask and face is made with downward pressure of the palm, centered on the mask, and jaw lift is achieved with 4 fingers centered under the mandible. The purpose of this study was to evaluate the safety and effectiveness of the Tao mask compared to a standard mask before and after the administration of neuromuscular blockade (NMB) using 2 previously established ventilation scales...
November 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29134045/teaching-games-for-understanding-a-comprehensive-approach-to-promote-student-s-motivation-in-physical-education
#10
David Hortigüela Alcalá, Alejandra Hernando Garijo
It seems important to consider students' attitudes towards physical education (PE), and the way they learn sports. The present study examines students' perceptions of motivation and achievement in PE after experiencing three consecutive sport units. Two hundred and thirty seven students from the 1st, 2nd, 3rd, and 4th grade in a high school in Burgos (Spain) and two teachers agreed to participate. They were divided into two groups in order to compare two instructional approaches. The experimental group (A), 128 students, experienced Teaching Games for Understanding (TGfU), while the control group (B), 109 students, experienced a technical-traditional approach...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29133265/critical-under-reporting-of-hernia-mesh-properties-and-development-of-a-novel-package-label
#11
Lindsey G Kahan, Jeffrey A Blatnik
BACKGROUND: With an array of hernia meshes with varying properties, intraoperative decision making for the optimal mesh is critical. While meshes are subjected to regulatory review through the FDA, it is unknown whether mesh properties are visually accessible. To facilitate greater knowledge for the surgeon on mesh choice, we aimed to comprehensively analyze hernia mesh packaging and regulations. STUDY DESIGN: Labeling guidelines and 510(k) requirements across FDA-regulated products were analyzed and compared to mesh packaging...
November 10, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29132876/the-distraction-in-action-tool%C3%A2-feasibility-and-usability-in-clinical-settings
#12
Kirsten Hanrahan, Charmaine Kleiber, Ben J Miller, Heather Davis, Ann Marie McCarthy
PURPOSE: Distraction is a relatively simple, evidence-based intervention to minimize child distress during medical procedures. Timely on-site interventions that instruct parents on distraction coaching are needed. The purpose of this study was to test the feasibility and usability of the Distraction in Action Tool© (DAT©), which 1) predicts child risk for distress with a needle stick and 2) provides individualized instructions for parents on how to be a distraction coach for their child in clinical settings...
November 10, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29131843/vertigo-and-dizziness-in-adolescents-risk-factors-and-their-population-attributable-risk
#13
Filipp M Filippopulos, Lucia Albers, Andreas Straube, Lucia Gerstl, Bernhard Blum, Thyra Langhagen, Klaus Jahn, Florian Heinen, Rüdiger von Kries, Mirjam N Landgraf
OBJECTIVES: To assess potential risk factors for vertigo and dizziness in adolescents and to evaluate their variability by different vertigo types. The role of possible risk factors for vertigo and dizziness in adolescents and their population relevance needs to be addressed in order to design preventive strategies. STUDY DESIGN: The study population consisted of 1482 school-children between the age of 12 and 19 years, who were instructed to fill out a questionnaire on different vertigo types and related potential risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/29130437/remote-hearing-aid-support-the-next-frontier
#14
Gina P Angley, Jean Anne Schnittker, Anne Marie Tharpe
BACKGROUND: In an effort to reduce health-care disparities, there has been a recent surge of interest in the remote provision of care. Audiologists have begun to provide screening, diagnostic, and rehabilitative services via telehealth technologies. PURPOSE: To evaluate the feasibility and perceived benefits of providing remote hearing aid follow-up appointments in a controlled clinical environment and in participants' homes. RESEARCH DESIGN: A descriptive quasi-experimental study was completed...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29130436/hearing-technology-use-and-management-in-school-age-children-reports-from-data-logs-parents-and-teachers
#15
Samantha J Gustafson, Todd A Ricketts, Anne Marie Tharpe
BACKGROUND: Consistency of hearing aid and remote microphone system use declines as school-age children with hearing loss age. One indicator of hearing aid use time is data logging, another is parent report. Recent data suggest that parents overestimate their children's hearing aid use time relative to data logging. The potential reasons for this disparity remain unclear. Because school-age children spend the majority of their day away from their parents and with their teachers, reports from teachers might serve as a valuable and additional tool for estimating hearing aid use time and management...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29128584/the-influence-of-maternal-modeling-on-body-image-concerns-and-eating-disturbances-in-preadolescent-girls
#16
Charlotte M Handford, Ronald M Rapee, Jasmine Fardouly
Research suggests that mothers may influence the development of body image concerns and eating disturbances in their daughters by modeling negative body image beliefs and unhealthy eating behaviors. However, the causal nature of that mode of influence is yet to be established. This study implemented an experimental design to examine the impact of mothers' modeling of negative comments about their own appearance and diet on their daughters' body image concerns and eating behaviors. Participants were 8-12 year old girls and their mothers (N = 50)...
November 6, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29128530/cell-instructive-pectin-hydrogels-crosslinked-via-thiol-norbornene-photo-click-chemistry-for-skin-tissue-engineering
#17
Rúben F Pereira, Cristina C Barrias, Paulo J Bártolo, Pedro L Granja
Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cell-degradable peptide crosslinkers and integrin-specific adhesive ligands. Protease-degradable hydrogels obtained by photoinitiated thiol-norbornene click chemistry are rapidly formed in the presence of dermal fibroblasts, exhibit tunable properties and are capable of modulating the behavior of embedded cells, including the cell spreading, hydrogel contraction and secretion of matrix metalloproteases...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29125855/functional-classification-of-grasp-strategies-used-by-hemiplegic-patients
#18
Alicia García Álvarez, Agnès Roby-Brami, Johanna Robertson, Nicolas Roche
This study aimed to identify and qualify grasp-types used by patients with stroke and determine the clinical parameters that could explain the use of each grasp. Thirty-eight patients with chronic stroke-related hemiparesis and a range of motor and functional capacities (17 females and 21 males, aged 25-78), and 10 healthy subjects were included. Four objects were used (tissue packet, teaspoon, bottle and tennis ball). Participants were instructed to "grasp the object as if you are going to use it". Three trials were video-recorded for each object...
2017: PloS One
https://www.readbyqxmd.com/read/29123101/symmetry-control-of-nanorod-superlattice-driven-by-a-governing-force
#19
Yujia Liang, Yong Xie, Dongxue Chen, Chuanfei Guo, Shuai Hou, Tao Wen, Fengyou Yang, Ke Deng, Xiaochun Wu, Ivan I Smalyukh, Qian Liu
Nanoparticle self-assembly promises scalable fabrication of composite materials with unique properties, but symmetry control of assembled structures remains a challenge. By introducing a governing force in the assembly process, we develop a strategy to control assembly symmetry. As a demonstration, we realize the tetragonal superlattice of octagonal gold nanorods, breaking through the only hexagonal symmetry of the superlattice so far. Surprisingly, such sparse tetragonal superstructure exhibits much higher thermostability than its close-packed hexagonal counterpart...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29122653/validation-of-an-automated-bilateral-feet-cold-pressor-test
#20
Petra Bachmann, Xinwei Zhang, Mauro F Larra, Dagmar Rebeck, Karsten Schönbein, Klaus P Koch, Hartmut Schächinger
The Cold Pressor Test (CPT) is often used in psychobiological research. However, the classical CPT version (unilateral hand immersion into ice-water) involves some disadvantages: hands may be needed for further applications, attentional drift towards the affected sensory hemi-field and/or physiological activation of the contralateral hemisphere may produce a laterality bias. Furthermore, instruction-induced motor activity may bias physiologic reactivity. To avoid these problems, a fully automated bilateral feet CPT was developed and tested for validity and feasibility...
November 6, 2017: International Journal of Psychophysiology
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