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https://www.readbyqxmd.com/read/28725907/development-of-a-new-immunoassay-for-human-cathepsin-k-generated-periostin-fragments-as-a-serum-biomarker-for-cortical-bone
#1
Patrick Garnero, Nicolas Bonnet, Serge L Ferrari
Periostin is a matricellular protein mainly expressed by periosteal cells and osteocytes in bone, but is also present in several other tissues. Available immunoassays use antibodies of unclear specificity. The aim of the study was to develop a bone-specific periostin ELISA based on the detection of fragments generated by the osteoclastic and osteocytic protease cathepsin K. In vitro digestion of human recombinant intact periostin by cathepsin K leads to the generation of multiple fragments. Using LS-MS/MS, it was found that the GSLQPIIK peptide was the most efficiently and abundantly generated periostin fragment...
July 19, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28723225/preferential-generation-of-15-hete-pe-induced-by-il-13-regulates-goblet-cell-differentiation-in-human-airway-epithelial-cells
#2
Jinming Zhao, Yoshinori Minami, Emily Etling, John M Coleman, Sarah N Lauder, Victoria Tyrrell, Maceler Aldrovandi, Valerie O'Donnell, Hans-Erik Claesson, Valerian Kagan, Sally Wenzel
RATIONALE: Type-2-associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase (15LO1) is induced by the Type-2 cytokines/IL-13 in human airway epithelial cells (HAEC) in vitro and is increased in fresh asthmatic HAECs ex vivo. 15LO1 generates a variety of products, including 15-hydroxyeicosatetraenoic acid (15-HETE), 15-HETE-phosphatidyethanoloamine (PE) (15-HETE-PE) and 13-hydroxyoctadecadienoic acid (13-HODE). The current study investigated the 15LO1 metabolite profile at baseline and after IL-13 treatment, and the influence on goblet cell differentiation in HAECs...
July 19, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28721208/new-perspectives-on-the-regulation-of-type-ii-inflammation-in-asthma
#3
REVIEW
Mireya Becerra-Díaz, Marsha Wills-Karp, Nicola M Heller
Asthma is a chronic inflammatory disease of the lungs which has been thought to arise as a result of inappropriately directed T helper type-2 (Th2) immune responses of the lungs to otherwise innocuous inhaled antigens. Current asthma therapeutics are directed towards the amelioration of downstream consequences of type-2 immune responses (i.e. β-agonists) or broad-spectrum immunosuppression (i.e. corticosteroids). However, few approaches to date have been focused on the primary prevention of immune deviation...
2017: F1000Research
https://www.readbyqxmd.com/read/28716282/serum-amyloid-p-component-a-novel-potential-player-in-vessel-degeneration-in-cadasil
#4
Akihito Nagatoshi, Mitsuharu Ueda, Akihiko Ueda, Masayoshi Tasaki, Yasuteru Inoue, Yihong Ma, Teruaki Masuda, Mayumi Mizukami, Sayaka Matsumoto, Takayuki Kosaka, Takayuki Kawano, Takaaki Ito, Yukio Ando
In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), granular osmiophilic material (GOM) may play some roles in inducing cerebrovascular events. To elucidate the pathogenesis of CADASIL, we used laser microdissection and liquid chromatography-tandem mass spectrometry to analyze cerebrovascular lesions of patients with CADASIL for GOM. The analyses detected serum amyloid P component (SAP), annexin A2, and periostin as the proteins with the largest increase in the samples, which also demonstrated NOTCH3...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28704185/phenotypes-determined-by-cluster-analysis-in-moderate-to-severe-bronchial-asthma
#5
Vania M Youroukova, Denitsa G Dimitrova, Anna D Valerieva, Spaska S Lesichkova, Tsvetelina V Velikova, Ekaterina I Ivanova-Todorova, Kalina D Tumangelova-Yuzeir
BACKGROUND: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. AIM: To identify phenotypes using cluster analysis in moderate to severe bronchial asthma and to compare differences in clinical, physiological, immunological and inflammatory data between the clusters. PATIENTS AND METHODS: Forty adult patients with moderate to severe bronchial asthma out of exacerbation were included...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28701644/periostin-in-allergic-diseases
#6
Kenji Izuhara
No abstract text is available yet for this article.
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28693214/clustering-of-patients-with-intrahepatic-cholangiocarcinoma-based-on-serum-periostin-may-be-predictive-of-prognosis
#7
Chanitra Thuwajit, Peti Thuwajit, Pranisa Jamjantra, Chawalit Pairojkul, Sopit Wongkham, Vajarabhongsa Bhudhisawasdi, Junya Ono, Shoichiro Ohta, Kiminori Fujimoto, Kenji Izuhara
An effective serum biomarker may improve cholangiocarcinoma (CCA) management. Periostin (PN) has been demonstrated to be associated with aggressive CCA. The current study evaluated PN in blood serum for its diagnostic and prognostic potential in patients with CCA. Sera of 68 patients with CCA were collected prior to treatment, and PN levels were measured using an ELISA. Sera from 50 normal controls, 6 patients with benign liver diseases, 2 with hepatocellular carcinoma and 21 with breast cancer were analyzed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693179/association-between-periostin-and-epithelial-mesenchymal-transition-in-esophageal-squamous-cell-carcinoma-and-its-clinical-significance
#8
Ya-Jing Lv, Wei Wang, Chu-Shu Ji, Jia, Ming-Ran Xie, Bing Hu
The present study aimed to investigate the association between periostin (POSTN), epithelial cadherin (E-cad) and vimentin (Vim) expression levels in esophageal squamous cell carcinoma (ESCC) tissues, and its clinicopathological significance. A total of 58 patients with esophageal cancer were enrolled. Immunohistochemistry was performed to quantify the expression levels of POSTN, E-cad and Vim. E-cad expression was reduced in ESCC tissue, which was associated with severe tumor node metastasis (TNM) stage (P<0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28687929/periostin-promotes-ectopic-osteogenesis-of-ctla4-modified-bone-marrow-mesenchymal-stem-cells
#9
Fei Zhang, Zhigang Rong, Zhengdong Wang, Zehua Zhang, Dong Sun, Shiwu Dong, Jianzhong Xu, Fei Dai
The improved ectopic osteogenesis of cytotoxic T-lymphocyte-associated antigen 4-Ig-modified bone marrow mesenchymal stem cells (MSCs-CTLA4) has been demonstrated but the mechanisms involved remain to be determined. The extracellular matrix (ECM) has recently been reported to play a vital role in bone formation and periostin (POSTN) has been suggested as a key member in constructing the ECM in bone tissue. We found that POSTN expression in the MSCs-CTLA4 group is significantly enhanced compared with that in the MSCs group, not only in tissue-engineered bone (TEB) with femur heterotopic transplantation in vivo but also under the immune activation condition in vitro...
July 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28687335/a-genome-wide-transcriptomic-analysis-of-articular-cartilage-during-normal-maturation-in-pigs
#10
Naga Suresh Adapala, Harry K W Kim
OBJECTIVE: The articular cartilage undergoes dramatic changes in structure and composition during post-natal maturation, but the associated transcriptional changes are not well characterized. Compared to a mature stage, the immature articular cartilage shows developmental features such as increased thickness, presence of blood vessels, and the presence of a deep layer of growth cartilage which undergoes endochondral ossification. These features decrease during normal development. Following maturation, the articular cartilage is known to undergo few minor modifications...
July 4, 2017: Gene
https://www.readbyqxmd.com/read/28669815/immuno-proteomic-discovery-of-tumor-tissue-autoantigens-identifies-olfactomedin-4-cd11b-and-integrin-alpha-2-as-markers-of-colorectal-cancer-with-liver-metastases
#11
Qian Yang, Prashant Bavi, Julia Y Wang, Michael H Roehrl
Late-stage colorectal cancer with liver metastasis is common and affords poor prognosis, yet there is a dearth of reliable biomarkers. Cancer is often characterized by an increase in serologic autoantibodies. Hence, we embarked on an immuno-proteomic strategy by using autoantibodies to discover antigens in tumor tissue as potential cancer markers. Matched sets of tissues from primary colon cancer, liver metastases, and adjacent benign tissues were obtained from colon cancer patients. Tissue proteins were extracted, and autoantigens were uncovered by immunoblotting with autoantibodies and sequenced by mass spectrometry...
June 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28668564/serum-periostin-concentrations-and-outcomes-after-severe-traumatic-brain-injury
#12
Xiao-Qiao Dong, Wen-Hua Yu, Quan Du, Hao Wang, Qiang Zhu, Ding-Bo Yang, Zhi-Hao Che, Yong-Feng Shen, Li Jiang
BACKGROUND: Periostin, a neurite outgrowth-promoting factor, is increasingly expressed in rat brain tissues after cerebral ischemia or subarachnoid hemorrhage. However, periostin concentrations are undetermined in peripheral blood from patients with traumatic brain injury (TBI). METHODS: In this prospective, observational study, serum periostin concentrations were measured in 130 controls and 130 severe TBI patients. We investigated its association with trauma severity reflected by Glasgow Coma Scale (GCS) score and prognosis (i...
June 28, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28667737/periostin-as-a-marker-of-mucosal-remodelling-in-chronic-rhinosinusitis
#13
J A Ebenezer, J M Christensen, B G Oliver, R A Oliver, G Tjin, J Ho, A R Habib, J Rimmer, R Sacks, R J Harvey
BACKGROUND: Although extracellular matrix (ECM) proteins are associated with irreversible lower airway changes, the relationship with upper airway remodelling which occurs during chronic rhinosinusitis (CRS) is poorly understood. This study assessed the expression of ECM proteins periostin, fibulin-1, fibronectin and collagenIV in nasal mucosa of patients with and without histologic features of remodelling. METHODS: A cross-sectional study of sinonasal mucosal biopsies taken from patients, undergoing surgery for CRS was performed, where patients were grouped according to remodelling, defined by basement membrane thickening (BMT over 7...
July 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28665915/prognostic-significance-of-periostin-and-mammalian-target-of-rapamycin-mtor-in-locally-advanced-esophageal-squamous-cell-carcinoma
#14
Qi Jiang, Jingjing Chen, Boyun Zhang, Junyang Niu, Yifu He
BACKGROUND Periostin and the mammalian target of rapamycin (mTOR) are involved in several cancers. This study aimed to evaluate the expression level of periostin and mTOR in locally advanced esophageal squamous cell carcinoma (ESCC) and to analyze their correlations with prognostic value. MATERIAL AND METHODS Expression levels of periostin and mTOR were examined by immunohistochemistry in locally advanced ESCC and corresponding adjacent normal tissue of 71 patients. The expression of periostin and mTOR were correlated with clinicopathologic characteristics by χ² test or Kruskal-Wallis analysis...
June 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28659663/a-role-of-the-abcc4-gene-polymorphism-in-airway-inflammation-of-asthmatics
#15
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang, Hae-Sim Park, Seung-Hyun Kim
The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane. Those metabolites play important roles in asthma. We investigated the potential associations between ABCC4 gene polymorphisms and asthma phenotype. In total, 270 asthma patients and 120 normal healthy controls were enrolled for a genetic association study. Two polymorphisms (-1508A>G and -642C>G) in the ABCC4 promoter were genotyped...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28655726/high-density-lipoproteins-and-type-2-inflammatory-biomarkers-are-negatively-correlated-in-atopic-asthmatics
#16
Amisha V Barochia, Elizabeth M Gordon, Maryann Kaler, Rosemarie A Cuento, Patricia Theard, Debbie M Figueroa, Xianglan Yao, Nargues A Weir, Maureen L Sampson, Mario Stylianou, David F Choy, Cecile T J Holweg, Alan T Remaley, Stewart J Levine
Blood eosinophil counts and serum periostin levels are biomarkers of type 2 inflammation. Although serum levels of HDL (high-density lipoprotein) and apolipoprotein A-I have been associated with less severe airflow obstruction in asthma, it is not known whether serum lipids or lipoprotein particles are correlated with type 2 inflammation in asthmatics. Here, we assessed whether serum lipids and lipoproteins correlated with blood eosinophil counts or serum periostin levels in 165 atopic asthmatics, and 163 non-asthmatic subjects with and without atopy...
June 27, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28644349/filaggrin-and-periostin-expression-is-altered-in-eosinophilic-esophagitis-and-normalized-with-treatment
#17
Ekaterini Politi, Aspasia Angelakopoulou, Dimitra Grapsa, Maria Zande, Kalliopi Stefanaki, Ioanna Panagiotou, Eleftheria Roma, Ekaterini Syrigou
OBJECTIVES: Previous data have suggested that filaggrin (FLG) and periostin (POSTN) genes may be dysregulated in eosinophilic esophagitis (EoE). We aimed to further evaluate the expression patterns of FLG and POSTN proteins in esophageal tissue samples of patients with EoE, as compared to those of patients with gastroesophageal reflux disease (GERD) and normal controls. METHODS: A total of 61 prospectively collected cases, including 40 children with EoE and 21 children with GERD, and a control group of 14 sex- and age-matched healthy children were enrolled...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28639369/a-network-analysis-to-compare-biomarker-profiles-in-patients-with-and-without-diabetes-mellitus-in-acute-heart-failure
#18
Abhinav Sharma, Biniyam G Demissei, Jasper Tromp, Hans L Hillege, John G Cleland, Christopher M O'Connor, Marco Metra, Piotr Ponikowski, John R Teerlink, Beth A Davison, Michael M Givertz, Daniel M Bloomfield, Howard Dittrich, Dirk J van Veldhuisen, Gad Cotter, Justin A Ezekowitz, Mohsin A F Khan, Adriaan A Voors
AIMS: It is unclear whether distinct pathophysiological processes are present among patients with acute heart failure (AHF), with and without diabetes. Network analysis of biomarkers may identify correlative associations that reflect different pathophysiological pathways. METHODS AND RESULTS: We analysed a panel of 48 circulating biomarkers measured within 24 h of admission for AHF in a subset of patients enrolled in the PROTECT trial. In patients with and without diabetes, we performed a network analysis to identify correlations between measured biomarkers...
June 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28631851/an-association-between-periostin-levels-with-the-severity-and-chronicity-of-atopic-dermatitis-in-children
#19
Myongsoon Sung, Kyung Suk Lee, Eun Gyo Ha, Seung Jin Lee, Mi Ae Kim, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Young Ho Jung, Man Yong Han
BACKGROUND: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Of the 4,076 children, 196 including 137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group were included for the final analysis...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28624215/periostin-binding-dna-aptamer-treatment-ameliorates-peritoneal-dialysis-induced-peritoneal-fibrosis
#20
Bo Young Nam, Jung Tak Park, Young Eun Kwon, Jung Pyo Lee, Jong Ha Jung, Youndong Kim, Seonghun Kim, Jimin Park, Jae Eun Um, Meiyan Wu, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
Peritoneal fibrosis is a major complication in peritoneal dialysis (PD) patients, which leads to dialysis discontinuation. Periostin, increased by transforming growth factor β1 (TGF-β1) stimulation, induces the expression of extracellular matrix (ECM) genes. Aberrant periostin expression has been demonstrated to be associated with PD-related peritoneal fibrosis. Therefore, the effect of periostin inhibition by an aptamer-based inhibitor on peritoneal fibrosis was evaluated. In vitro, TGF-β1 treatment upregulated periostin, fibronectin, α-smooth muscle actin (α-SMA), and Snail expression and reduced E-cadherin expression in human peritoneal mesothelial cells (HPMCs)...
June 16, 2017: Molecular Therapy. Nucleic Acids
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