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https://www.readbyqxmd.com/read/29774119/periostin-a-signal-transduction-intermediate-in-tgf-%C3%AE-induced-emt-in-u-87mg-human-glioblastoma-cells-and-its-inhibition-by-anthocyanidins
#1
Amira Ouanouki, Sylvie Lamy, Borhane Annabi
Periostin is a secreted protein that is highly expressed in glioblastoma cells as compared to normal brain tissue, and is therefore considered as a potential biomarker in therapeutic modalities. Its contribution in the cancer cells invasive phenotype is, however, poorly understood. This work investigates the role of periostin in U-87 MG glioblastoma cell invasion, cell migration and in Transforming Growth Factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT). Periostin gene silencing, using small interfering RNA, decreased TGF-β-induced mesenchymal marker expression of fibronectin and vimentin, partly through reduced Smad2, Akt and Fak phosphorylation as well as U-87 MG cell invasion and migration...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29761164/periostin-and-mesothelin-potential-predictors-of-malignant-progression-in-intrahepatic-cholangiocarcinoma
#2
EDITORIAL
Pranoti Mandrekar, Vincenzo Cardinale
No abstract text is available yet for this article.
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29754498/axonal-guidance-signaling-pathway-is-suppressed-in-human-nasal-polyps
#3
Dawei Wu, Sarina K Mueller, Angela L Nocera, Kristen Finn, Towia A Libermann, Benjamin S Bleier
Background Dysfunctional innervation might contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), but the state of the axonal outgrowth signaling in CRSwNP is unknown. The purpose of this study was to explore the axonal outgrowth pathway-related protein expression in CRSwNP. Methods Institutional review board approved study in which tissue proteomes were compared between control and CRSwNP patients (n = 10/group) using an aptamer-based proteomic array and confirmed by whole transcriptomic analysis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29754406/targeting-twist1-through-loss-of-function-inhibits-tumorigenicity-of-human-glioblastoma
#4
Andrei M Mikheev, Svetlana A Mikheeva, Liza J Severs, Cory C Funk, Lei Huang, José L McFaline-Figueroa, Jeanette Schwensen, Cole Trapnell, Nathan D Price, Stephen Wong, Robert C Rostomily
Twist1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial to mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion and self-renewal in glioblastoma (GBM) cells. However the potential therapeutic relevance of TW has not been established through loss of function studies in human GBM cell xenograft models. The effects of TW loss of function (gene editing and knock down) on inhibition of tumorigenicity of U87MG and GBM4 glioma stem cells were tested in orthotopic xenograft models and conditional knockdown in established flank xenograft tumors...
May 13, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29749440/vitamin-k%C3%A2-dependent-proteins-involved-in-bone-and-cardiovascular-health-review
#5
Lianpu Wen, Jiepeng Chen, Lili Duan, Shuzhuang Li
In postmenopausal women and elderly men, bone density decreases with age and vascular calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A total of 17 different vitamin K‑dependent proteins have been identified to date. Vitamin K‑dependent proteins are located within the bone, heart and blood vessels. For instance, carboxylated osteocalcin is beneficial for bone and aids the deposition of calcium into the bone matrix. Carboxylated matrix Gla protein effectively protects blood vessels and may prevent calcification within the vascular wall...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29746003/ige-sensitisation-to-food-allergens-and-airborne-allergens-in-relation-to-biomarkers-of-type-2-inflammation-in-asthma
#6
A Patelis, K Alving, R Middelveld, A James, J Ono, S Ohta, K Izuhara, M P Borres, B Forsberg, C Janson, A Malinovschi
BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. OBJECTIVE: To investigate the relation between IgE sensitisation and several type 2 inflammation biomarkers in adult asthmatics. METHODS: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study...
May 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29741411/biomarkers-for-severe-allergic-asthma-in-children-could-they-be-useful-to-guide-disease-control-and-use-of-omalizumab
#7
Flore Amat, André Labbé
Although symptom controls in asthmatic children can be achieved through compliant use of conventional medication, some children have uncontrolled severe persistent asthma, especially if they are allergic. For these children, omalizumab (approved by the EMA and FDA in children aged > 6 years) could be a therapeutic option. However, response to omalizumab varies from one child to another. Predictive biomarkers of omalizumab effectiveness could be useful to monitor response to treatment. Area covered: The authors searched in the PubMed database for publications related to the use of biomarkers in allergic asthma...
May 16, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29731999/periostin-attenuates-tumor-growth-by-inducing-apoptosis-in-colitis-related-colorectal-cancer
#8
Yusuke Shimoyama, Keiichi Tamai, Rie Shibuya, Mao Nakamura, Mai Mochizuki, Kazunori Yamaguchi, Yoichi Kakuta, Yoshitaka Kinouchi, Ikuro Sato, Akira Kudo, Tooru Shimosegawa, Kennichi Satoh
Inflammatory bowel diseases, which are multifactorial autoimmune colitis diseases, are occurring with increasing prevalence. One of the most serious complications of these diseases is colorectal cancer. Here we investigated the role of periostin (Postn), a matricellular protein that interacts with various integrin molecules on the cell surface, in colitis-induced colorectal cancer. Immunohistochemistry of mouse and human colorectal cancer samples revealed that Postn was expressed in the stroma and was upregulated in close proximity to the cancer cells...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29725485/prognostic-value-of-periostin-in-early-stage-breast-cancer-treated-with-conserving-surgery-and-radiotherapy
#9
Changyou Li, Jing Xu, Qi Wang, Shaoqing Geng, Zheng Yan, Jin You, Zhenfeng Li, Xiao Zou
The present study was performed to explore the prognostic significance of periostin expression in a cohort of patients with early-stage breast cancer treated with breast conserving surgery following radiotherapy. A tissue microarray of tumor samples from 259 patients with early-stage breast cancer was assayed for periostin, estrogen receptor (ER), progesterone receptor (PR), ErbB2 receptor tyrosine kinase 2 and Ki-67 expression by immunohistochemistry. The association of periostin with other clinicopathological parameters and clinical outcomes, including local recurrence free survival (RFS), distant metastasis free survival (DFS) and overall survival (OS), were assessed through log-rank tests and univariate and multivariate analysis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29695980/cardiac-remodeling-endothelial-cells-have-more-to-say-than-just-no
#10
REVIEW
Vincent F M Segers, Dirk L Brutsaert, Gilles W De Keulenaer
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within the organ, with subsequent optimization of its function. Intercellular cross-talk is indispensable during cardiac development, but also plays a substantial modulatory role in the normal and failing heart of adults. More specifically, factors secreted by cardiac microvascular endothelial cells modulate cardiac performance and either positively or negatively affect cardiac remodeling...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29672593/il-13-induces-periostin-and-eotaxin-expression-in-human-primary-alveolar-epithelial-cells-comparison-with-paired-airway-epithelial-cells
#11
Yoko Ito, Reem Al Mubarak, Nicole Roberts, Kelly Correll, William Janssen, James Finigan, Rangnath Mishra, Hong Wei Chu
Alveolar epithelial cells are critical to the pathogenesis of pulmonary inflammation and fibrosis, which are associated with overexpression of type 2 cytokine IL-13. IL-13 is known to induce the production of profibrotic (e.g., periostin) and pro-inflammatory (e.g., eotaxin-3) mediators in human airway epithelial cells, but it remains unclear if human primary alveolar epithelial cells increase periostin and eotaxin expression following IL-13 stimulation. The goals of this study are to determine if alveolar epithelial cells increase periostin and eotaxin expression upon IL-13 stimulation, and if alveolar and airway epithelial cells from the same subjects have similar responses to IL-13...
2018: PloS One
https://www.readbyqxmd.com/read/29665811/recombinant-mouse-periostin-ameliorates-coronal-sutures-fusion-in-twist1-mice
#12
Shanshan Bai, Dong Li, Liang Xu, Huichuan Duan, Jie Yuan, Min Wei
BACKGROUND: Saethre-Chotzen syndrome is an autosomal dominantly inherited disorder caused by mutations in the twist family basic helix-loop-helix transcription factor 1 (TWIST1) gene. Surgical procedures are frequently required to reduce morphological and functional defects in patients with Saethre-Chotzen syndrome. Therefore, the development of noninvasive procedures to treat Saethre-Chotzen syndrome is critical. We identified that periostin, which is an extracellular matrix protein that plays an important role in both bone and connective tissues, is downregulated in craniosynostosis patients...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29664015/a-new-concept-of-fibroblast-dynamics-in-post-myocardial-infarction-remodeling
#13
Thomas Eschenhagen
The identity and function of the fibroblast, a highly prevalent cell type in the heart, have remained poorly defined. Recent faithful genetic lineage-tracing studies revealed that during development, the cardiac fibroblasts are derived from the epicardium and the endothelium, whereas in the adult heart, they constitute the cardiac injury-responsive resident fibroblast. In the current issue of the JCI, Molkentin and colleagues decipher the time course and mechanism of the fibroblast in response to myocardial infarction (MI)...
May 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29648484/serum-periostin-levels-serve-as-a-biomarker-for-both-eosinophilic-airway-inflammation-and-fixed-airflow-limitation-in-well-controlled-asthmatics
#14
Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-Ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara, Itsuo Iwamoto
OBJECTIVE: Periostin, a matricellular protein, is produced from airway epithelial cells and lung fibroblasts by IL-13. It has been suggested that periostin is involved in allergic inflammation and fibrosis. However, the usefulness of serum periostin measurement in the assessment of airway inflammation and remodeling and management of asthmatic patients is still debated. We aimed to determine whether serum periostin levels reflect eosinophilic airway inflammation and airway remodeling in asthma...
April 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29610343/transient-fibrosis-resolves-via-fibroblast-inactivation-in-the-regenerating-zebrafish-heart
#15
Héctor Sánchez-Iranzo, María Galardi-Castilla, Andrés Sanz-Morejón, Juan Manuel González-Rosa, Ricardo Costa, Alexander Ernst, Julio Sainz de Aja, Xavier Langa, Nadia Mercader
In the zebrafish ( Danio rerio ), regeneration and fibrosis after cardiac injury are not mutually exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) proteins accumulate at the injury site. However, in contrast to the situation in mammals, fibrosis is transient in zebrafish and its regression is concomitant with regrowth of the myocardial wall. Little is known about the cells producing this fibrotic tissue or how it resolves. Using novel genetic tools to mark periostin b - and collagen 1alpha2 ( col1a2 )-expressing cells in combination with transcriptome analysis, we explored the sources of activated fibroblasts and traced their fate...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29609049/type-2-biomarkers-and-prediction-of-future-exacerbations-and-lung-function-decline-in-adult-asthma
#16
Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
BACKGROUND: Type 2 biomarkers that predict both likelihood of future severe exacerbations and response to monoclonal antibody therapy in asthma, would be useful clinically in identifying patients both at greater risk of hospitalization, and most likely to benefit from monoclonal antibody therapy. OBJECTIVE: To describe the association between the Type 2 biomarkers, blood eosinophils, FeNO, serum periostin, serum IgE and time to severe exacerbation in a broad asthma population...
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29604251/atopic-dermatitis-subjects-colonized-with-staphylococcus-aureus-have-a-distinct-phenotype-and-endotype
#17
Eric L Simpson, Miguel Villarreal, Brett Jepson, Nick Rafaels, Gloria David, Jon Hanifin, Patricia Taylor, Mark Boguniewicz, Takeshi Yoshida, Anna De Benedetto, Kathleen C Barnes, Donald Y M Leung, Lisa A Beck
Atopic dermatitis (AD) patients are commonly colonized with Staphylococcus aureus (ADS.aureus+) but what differentiates this group from noncolonized AD subjects (ADS.aureus-) has not been well-studied. To evaluate whether these two groups have unique phenotypic or endotypic features we performed a multi-center, cross-sectional study enrolling ADS.aureus+ (N=51) and ADS.aureus- (N=45) subjects defined by the presence or absence of S. aureus by routine culture techniques and nonatopic, noncolonized controls NAS...
March 28, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29593061/biomarkers-of-chondrosarcoma
#18
REVIEW
Wonju Jeong, Ha-Jeong Kim
Clinical outcome prediction is major concern to patients with cancer. Various molecular markers in various carcinomas have been identified in the past few decades. However, accurate predictors in chondrosarcoma have not been developed, even though chondrosarcoma is the second most common primary bone tumour. Chondrosarcoma is the cartilage-forming malignancy and shows a wide spectrum of clinicopathological behaviours. The majority of chondrosarcoma grows slowly and rarely metastasises, and adequate surgery leads to a good prognosis...
March 28, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29580282/plasma-ykl-40-and-ngal-are-useful-in-distinguishing-aco-from-asthma-and-copd
#19
Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He, Depeng Jiang
BACKGROUND: Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the early recognition of ACO is crucial. OBJECTIVES: We sought to explore the plasma levels of biomarkers associated with asthma (periostin, TSLP and YKL-40), COPD (NGAL) and their possible correlation with lung function, the bronchodilator response and radiographic imaging in patients with asthma, COPD and with features of ACO...
March 27, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29577044/tubulointerstitial-biomarkers-for-diabetic-nephropathy
#20
REVIEW
Bancha Satirapoj
Patients with diabetic nephropathy have a higher risk of mortality, mostly from cardiovascular complications. Standard biomarkers including serum creatinine, estimated glomerular filtration rate, and albuminuria are imprecise, do not directly measure renal tissue injury, and are relatively insensitive to small changes in renal function. Thus, availability of novel biomarkers that are sensitive, specific, and precise as well as able to detect kidney injury and predict clinically significant outcomes would be widely useful in diabetic nephropathy...
2018: Journal of Diabetes Research
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