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https://www.readbyqxmd.com/read/29142596/role-and-underlying-mechanisms-of-the-interstitial-protein-periostin-in-the-diagnosis-and-treatment-of-malignant-tumors
#1
Dong Ye, Zhi Sen Shen, Shi Jie Qiu, Qun Li, Guo Li Wang
Invasion and metastasis are the major characteristics of malignant tumors and are complex processes involving multiple genes. Gene regulation is a precise, large and complex biological control system, and its underlying mechanisms remain to be elucidated. Mesenchymal-specific genes are expressed primarily by mesenchymal cells, and the expression products of these genes are molecules with various structures and functions, including secreted proteins and extracellular matrix proteins. The periostin gene has been newly identified as a mesenchymal-specific gene and an extracellular-matrix secreted protein...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29122495/up-regulation-of-serum-periostin-and-squamous-cell-carcinoma-antigen-levels-in-infants-with-acute-bronchitis-due-to-respiratory-syncytial-virus
#2
Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
BACKGROUND: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. METHODS: Infants younger than 36 months were enrolled and classified into three groups...
November 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29101484/periostin-in-cardiovascular-disease-and-development-a-tale-of-two-distinct-roles
#3
REVIEW
Natalie M Landry, Smadar Cohen, Ian M C Dixon
Tissue development and homeostasis are dependent upon the concerted synthesis, maintenance, and degradation of extracellular matrix (ECM) molecules. Cardiac fibrosis is now recognized as a primary contributor to incidence of heart failure, particularly heart failure with preserved ejection fraction, wherein cardiac filling in diastole is compromised. Periostin is a cell-associated protein involved in cell fate determination, proliferation, tumorigenesis, and inflammatory responses. As a non-structural component of the ECM, secreted 90 kDa periostin is emerging as an important matricellular factor in cardiac mesenchymal tissue development...
November 3, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29096644/serum-periostin-levels-in-early-in-pregnancy-are-significantly-altered-in-women-with-miscarriage
#4
A Freis, J Schlegel, R J Kuon, A Doster, J Jauckus, T Strowitzki, A Germeyer
BACKGROUND: Miscarriage is a common complication in pregnancy and there is still a lack of biomarkers usable in asymptomatic patients before the event occurs. Periostin (PER), whose levels rise particularly during injury or inflammation, has been shown to play an important local role in implantation and early embryonic development. As PER has been described as a biomarker in various medical conditions we intended to evaluate if changes in PER serum levels may help to identify women at risk for spontaneous abortion in the first trimester...
November 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29095886/identification-of-a-novel-angiogenic-peptide-from-periostin
#5
Ba Reun Kim, Yang Woo Kwon, Gyu Tae Park, Eun Jung Choi, Jeong Kon Seo, Il Ho Jang, Seung-Chul Kim, Hyun-Chang Ko, Sang Chul Lee, Jae Ho Kim
Angiogenic peptides have therapeutic potential for the treatment of chronic ischemic diseases. Periostin, an extracellular matrix protein expressed in injured tissues, promotes angiogenesis and tissue repair. We previously reported that in vivo administration of both recombinant full-length protein and the first FAS I domain of periostin alleviated peripheral artery occlusive disease by stimulating the migration of humane endothelial colony forming cells (ECFCs) and subsequent angiogenesis. In the present study, we ascertained the peptide sequence responsible for the periostin-induced angiogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29081260/diagnostic-significance-of-serum-periostin-in-eosinophilic-chronic-sinusitis-with-nasal-polyps
#6
Ming Xu, Weiwei Zhang, Daishi Chen, Haojie Zhou, Lei Chen
OBJECTIVES: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. Eosinophilic CRSwNP (ENP) exhibits a strong tendency for recurrence after surgery. Given that the treatment strategy of ENP differs from that of non-eosinophilic CRSwNP (nENP), clinical diagnostic criteria that distinguish ENP from nENP are needed. METHODS: In total, 94 CRSwNP patients were enrolled in the cohort. Factors associated with ENP were determined with regression analysis, and optimal cutoff points of the predictors were determined by a receiver operating characteristic curve...
October 28, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29067102/growth-differentiation-factor-5-promotes-in-vitro-vivo-periodontal-specific-differentiation-of-induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells
#7
Xiaohui Yin, Peng Li, Yang Li, Yu Cai, Jinhua Wen, Qingxian Luan
Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) represent a promising alternative source of MSCs for effective periodontal regeneration. Scientific evidence has demonstrated that growth/differentiation factor-5 (GDF-5) supports regeneration of periodontal tissues and has a key role in MSC differentiation. The present study investigated the effects of recombinant human GDF-5 (rhGDF-5) on periodontal specific differentiation of iPSC-derived MSCs (iPSC-MSCs) and bone marrow mesenchymal stem cells (BMSCs)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29066614/targeting-the-stat6-pathway-in-tumor-associated-macrophages-reduces-tumor-growth-and-metastatic-niche-formation-in-breast-cancer
#8
Karin Binnemars-Postma, Ruchi Bansal, Gert Storm, Jai Prakash
Tumor-associated macrophages (TAMs) are the key effector cells in the tumor microenvironment and induce neoangiogenesis, matrix remodeling, and metastasis while suppressing the tumor immune system. These protumoral macrophages display an M2 phenotype induced by IL-4 and IL-13 cytokines. In this study, we hypothesized that the inhibition of the signal transducer and activator of transcription 6 (Stat6) pathway, a common downstream signaling pathway of IL-4 and IL-13, may be an interesting strategy by which to inhibit TAM differentiation and, thus, their protumorigenic activities...
October 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#9
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29040053/periostin-as-a-biomarker-for-nasal-polyps-in-chronic-rhinosinusitis
#10
Alice Z Maxfield, Lukas D Landegger, Christopher D Brook, Ashton E Lehmann, Adam P Campbell, Regan W Bergmark, Konstantina M Stankovic, Ralph Metson
Objective Periostin is an extracellular matrix protein that is elevated in the sinonasal tissues of patients with chronic rhinosinusitis (CRS). The purpose of this study was to determine whether serum periostin could serve as a molecular biomarker of nasal polyp burden in sinonasal disease. Study Design Prospective cohort study. Setting Academic medical center. Subjects and Methods Serum periostin levels were measured by ELISA on blood samples collected from patients undergoing sinus surgery for CRS (n = 71), further stratified by phenotype as defined by nasal polyps and asthma...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29038835/interaction-between-lrp5-and-periostin-gene-polymorphisms-on-serum-periostin-levels-and-cortical-bone-microstructure
#11
J Pepe, N Bonnet, F R Herrmann, E Biver, R Rizzoli, T Chevalley, S L Ferrari
We investigated the interaction between periostin SNPs and the SNPs of the genes assumed to modulate serum periostin levels and bone microstructure in a cohort of postmenopausal women. We identified an interaction between LRP5 SNP rs648438 and periostin SNP rs9547970 on serum periostin levels and on radial cortical porosity. PURPOSE: The purpose of this study is to investigate the interaction between periostin gene polymorphisms (SNPs) and other genes potentially responsible for modulating serum periostin levels and bone microstructure in a cohort of postmenopausal women...
October 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29038619/alteration-of-inflammatory-mediators-in-the-upper-and-lower-airways-under-chronic-intermittent-hypoxia-preliminary-animal-study
#12
Eun Jung Lee, Woon Heo, Joo Young Kim, Hyungchul Kim, Min Jung Kang, Bo Ra Kim, Ji Hyun Kim, Do Yang Park, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
PURPOSE: We hypothesized that CIH may affect the upper airway immune system and aimed to verify whether CIH can induce airway inflammation in a murine obstructive sleep apnea (OSA) model. METHODS: C57BL6 male mice were exposed to intermittent hypoxia (CIH group; 5 ~ 21% FiO2, 120 sec cycles, 12 h/d, n = 6) or room air (Sham group, n = 6) for up to 4 weeks in identical chambers. Nasal and lung tissues and lavage fluid were collected and analyzed by multiplex assay...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29036019/targeting-the-interleukin-4-and-interleukin-13-pathways-in-severe-asthma-current-knowledge-and-future-needs
#13
Amit D Parulekar, Christina C Kao, Zuzana Diamant, Nicola A Hanania
PURPOSE OF REVIEW: Severe asthma is a heterogeneous disease that can be classified into phenotypes and endotypes based upon clinical or biological characteristics. Interleukin (IL)-4 and IL-13 play a key role in type 2 (T2) asthma. This article reviews the signaling pathway of IL-4 and IL-13 and highlights its targeted therapy in severe asthma. RECENT FINDINGS: Several clinical trials of biologics targeting the IL-4/IL-13 pathway have recently been completed. In patients with severe, uncontrolled asthma, targeting IL-13 alone with biologics including lebrikizumab and tralokinumab has not shown consistent reduction in asthma exacerbations...
October 13, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29035604/biomarkers-for-differentiation-of-patients-with-asthma-and-chronic-obstructive-pulmonary-disease
#14
Shigeki Katoh, Masaki Ikeda, Ryo Shirai, Masaaki Abe, Yoshihiro Ohue, Yoshihiro Kobashi, Mikio Oka
OBJECTIVE: Asthma and chronic obstructive pulmonary disease (COPD) are airflow limitation diseases with similar clinical manifestations but different pathophysiologic mechanisms. To implement the appropriate treatment, it is important to distinguish between asthma and COPD which sometimes might result difficult in clinical practice. We evaluated biomarkers to distinguish between asthma and COPD. METHODS: Blood eosinophil counts and fractional exhaled nitric oxide (FeNO) levels were analyzed...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29025374/the-prognostic-significance-of-cancer-associated-fibroblasts-in-pancreatic-ductal-adenocarcinoma
#15
Hyunjin Park, Yangkyu Lee, Hyejung Lee, Jin-Won Kim, Jin-Hyeok Hwang, Jaihwan Kim, Yoo-Seok Yoon, Ho-Seong Han, Haeryoung Kim
Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression. In this study, we investigated the expression status of secreted protein acidic and rich in cysteine, periostin, fibroblast-activated protein, and the newly developed proCOL11A1 antibody in the stroma of surgically resected pancreatic ductal adenocarcinomas and their prognostic implications. Tissue microarrays were constructed from 155 surgically resected pancreatic ductal adenocarcinomas and paired non-neoplastic pancreata and from another independent set of 48 normal/benign pancreata, and immunohistochemical stains were performed for proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28988748/structural-and-functional-implications-of-human-transforming-growth-factor-%C3%AE-induced-protein-tgfbip-in-corneal-dystrophies
#16
Raquel García-Castellanos, Nadia Sukusu Nielsen, Kasper Runager, Ida B Thøgersen, Marie V Lukassen, Ebbe T Poulsen, Theodoros Goulas, Jan J Enghild, F Xavier Gomis-Rüth
A major cause of visual impairment, corneal dystrophies result from accumulation of protein deposits in the cornea. One of the proteins involved is transforming growth factor β-induced protein (TGFBIp), an extracellular matrix component that interacts with integrins but also produces corneal deposits when mutated. Human TGFBIp is a multi-domain 683-residue protein, which contains one CROPT domain and four FAS1 domains. Its structure spans ∼120 Å and reveals that vicinal domains FAS1-1/FAS1-2 and FAS1-3/FAS1-4 tightly interact in an equivalent manner...
November 7, 2017: Structure
https://www.readbyqxmd.com/read/28979110/differences-in-systemic-inflammation-between-cigarette-and-biomass-smoke-induced-copd
#17
Rafael Golpe, Irene Martín-Robles, Pilar Sanjuán-López, Luis Pérez-de-Llano, Carlos González-Juanatey, José L López-Campos, Elena Arellano-Orden
BACKGROUND AND OBJECTIVE: It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD. METHODS: A total of 20 subjects (15 men and five women) with T-COPD were matched one to one for sex, age and forced expiratory volume in 1 s (FEV1) to 20 B-COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28977942/periostin-promotes-epithelial-mesenchymal-transition-via-the-mapk-mir-381-axis-in-lung-cancer
#18
Wei-Wei Hu, Po-Chun Chen, Jun-Ming Chen, Yue-Ming Wu, Po-Yi Liu, Chih-Hao Lu, Yu-Feng Lin, Chih-Hsin Tang, Chia-Chia Chao
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a multifunctional cytokine that signals between the cell and the extracellular matrix. Periostin plays an important role in tumor development and is involved in carcinoma cell epithelial-mesenchymal transition (EMT), whereby mature epithelial cells undergo phenotypic morphological changes and become invasive, motile cells. Here, we discuss the molecular mechanisms involved in periostin-induced promotion of EMT in lung cancer cells. Online TCGA datasets demonstrate the prognostic relevance of periostin in lung cancer; a higher periostin level correlates with poor overall survival...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965986/deficiency-of-periostin-impairs-liver-regeneration-in-mice-after-partial-hepatectomy
#19
Tiantian Wu, Jingwen Huang, Shasha Wu, Zhengjie Huang, Xiaoyan Chen, Yingfu Liu, Dan Cui, Gang Song, Qi Luo, Fan Liu, Gaoliang Ouyang
Periostin (Postn) is a crucial extracellular remodeling factor that has been implicated in the pathogenesis of hepatic inflammation, fibrosis, non-alcoholic fatty liver disease and liver cancer. However, the role of Postn in liver regeneration remains unclear. Here, we demonstrate that Postn mRNA and protein levels are significantly upregulated in the mice after 2/3 partial hepatectomy (PHx). Compared with wild-type mice, Postn-deficient mice exhibit lower liver/body weight ratio and less Ki67-positive cells at days 2, 8 and 14 after PHx...
September 28, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28965266/periostin-silencing-suppresses-the-aggressive-phenotype-of-thyroid-carcinoma-cells-by-suppressing-the-akt-thyroid-stimulating-hormone-receptor-axis
#20
Min Wang, Chunyi Gui, Shenglong Qiu, Jingdong Tang, Zhihai Peng
Clinical evidence indicates that high periostin expression correlates with aggressive phenotype in thyroid carcinoma. However, the biological roles of periostin in thyroid carcinoma development and progression are still unclear. In this study, we explored the effects of periostin silencing on thyroid carcinoma cell growth, invasion, and tumorigenesis. We also studied the impact of periostin on the activation of phosphoinositide 3-kinase (PI3-K)/Akt signaling, which is involved in the pathogenesis of thyroid carcinoma...
September 30, 2017: Cytotechnology
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