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https://www.readbyqxmd.com/read/27905846/early-elevation-of-plasma-periostin-is-associated-with-chronic-ventilator-dependent-bronchopulmonary-dysplasia
#1
Shawn K Ahlfeld, Stephanie D Davis, Katherine J Kelley, Brenda B Poindexter
No abstract text is available yet for this article.
December 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27905395/outside-in-integrin-signalling-regulates-haematopoietic-stem-cell-function-via-periostin-itgav-axis
#2
Satish Khurana, Sarah Schouteden, Javed K Manesia, Albert Santamaria-Martínez, Joerg Huelsken, Adam Lacy-Hulbert, Catherine M Verfaillie
Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-αv (Itgav) regulates HSC proliferation. Systemic deletion of Postn results in peripheral blood (PB) anaemia, myelomonocytosis and lymphopenia, while the number of phenotypic HSCs increases in the bone marrow. Postn(-/-) mice recover faster from radiation injury with concomitant loss of primitive HSCs. HSCs from Postn(-/-) mice show accumulation of DNA damage generally associated with aged HSCs...
December 1, 2016: Nature Communications
https://www.readbyqxmd.com/read/27895734/periostin-and-tumor-stroma-interactions-in-non-small-cell-lung-cancer
#3
Ulrich Nitsche, Daniela Stangel, Zheng Pan, Anna Melissa Schlitter, Irene Esposito, Ivonne Regel, Susanne Raulefs, Helmut Friess, Jörg Kleeff, Mert Erkan
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality globally. Interactions of the cancer cells with the tumor microenvironment are essential carcinogenic features for the majority of solid tumors, such as pancreatic cancer. The present study investigated the role of stromal activation in NSCLC and analyzed the surgical specimens of 93 patients by immunohistochemistry with regard to periostin (an extracellular matrix protein), α-smooth muscle actin (α-SMA; a marker of myofibroblasts) and cluster of differentiation 31 (CD31; a marker of endothelial cells), and the activated stroma index...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27885258/circulating-periostin-in-relation-to-insulin-resistance-and-nonalcoholic-fatty-liver-disease-among-overweight-and-obese-subjects
#4
Zhen Yang, Hongmei Zhang, Yixin Niu, Weiwei Zhang, Lingfei Zhu, Xiaoyong Li, Shuai Lu, Jiangao Fan, Xiaoying Li, Guang Ning, Li Qin, Qing Su
Recent study showed periostin play a pivotal role in abnormal liver triglyceride (TG) accumulation and in the development of obesity-related liver fat accumulation. However, little is known regarding whether periostin plays a key role in the heightened prevalence of NAFLD and other metabolic phenotypes among large-scale populations. A cross-sectional sample of 8850 subjects aged 40 yr or older from China were evaluated in this study. Serum periostin was measured by ELISA methods. The diagnosis of NAFLD by liver ultrasonic examination...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872089/transcriptional-induction-of-periostin-by-a-sulfatase-2-tgf%C3%AE-1-smad-signaling-axis-mediates-tumor-angiogenesis-in-hepatocellular-carcinoma
#5
Gang Chen, Ikuo Nakamura, Renumathy Dhanasekaran, Eriko Iguchi, Ezequiel Tolosa, Paola Romecin-Duran, Renzo Vera, Luciana L Almada, Alexander Miamen, Roongruedee Chaiteerakij, Mengtao Zhou, Michael Asiedu, Catherine D Moser, Shaoshan Han, Chunling Hu, Bubu Banini, Abdul Oseini, Yichun Chen, Yong Fang, Dongye Yang, Hassan Shaleh, Shaoqing Wang, Dehai Wu, Tao Song, Ju-Seog Lee, Snorri S Thorgeirsson, Eric Chevet, Vijay H Shah, Martin E Fernandez-Zapico, Lewis Roberts
Existing anti-angiogenic approaches to treat metastatic hepatocellular carcinoma (HCC) are weakly effectual, prompting further study of tumor angiogenesis in this disease setting. Here we report a novel role for the sulfatase 2 (SULF2) in driving HCC angiogenesis. Sulf2-deficient mice (Sulf2 KO) exhibited resistance to diethylnitrosamine-induced HCC and did not develop metastases like wild-type mice (Sulf2 WT). The smaller and less numerous tumors formed in Sulf2 KO mice exhibited a markedly lower microvascular density...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27830727/exploration-of-the-sphingolipid-metabolite-sphingosine-1-phosphate-and-sphingosine-as-novel-biomarkers-for-aspirin-exacerbated-respiratory-disease
#6
Hoang Kim Tu Trinh, Su-Chin Kim, Kumsun Cho, Su-Jung Kim, Ga-Young Ban, Hyun-Ju Yoo, Joo-Youn Cho, Hae-Sim Park, Seung-Hyun Kim
Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL metabolites in aspirin-exacerbated respiratory disease (AERD). We aimed to explore the potential AERD biomarkers by conducting lipidomics targeting SL metabolites. The levels of SL metabolites in serum and urine samples from 45 AERD patients and 45 aspirin-tolerant asthma (ATA) patients were quantified through mass spectrometry. During the lysine-aspirin bronchoprovocation test (ASA-BPT), the levels of serum sphingomyelin (SM) were significantly decreased in AERD (P < 0...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826074/anatomical-differences-of-the-protein-profile-in-the-rabbit-sclera-during-growth
#7
Ying Liu, Pingbo Zhang, Jianbo Pan, Mark Augustine D'Souza, Craig P Dufresne, Richard D Semba, Jiang Qian, Deepak P Edward
We aimed to investigate the proteome changes in anatomical regions of sclera during growth and development of the rabbit. Sclera from New Zealand white rabbits of three ages (1 month, 2 months and 6 months) was dissected into three segments - anterior, equatorial, and posterior. A total of 36 samples were divided into groups by age and anatomical region. Tryptic digests of total proteins were analyzed by liquid chromatography followed by tandem mass spectrometry (LC-MS/MS). Label-free quantification based on spectral counts was used to determine the relative protein abundance and identify proteins with statistically significant differences between age groups or anatomical regions of the sclera...
November 5, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27818162/identification-of-axon-growth-promoters-in-the-secretome-of-the-deer-antler-velvet
#8
Wolfgang Pita-Thomas, Gemma Barroso-García, Veronica Moral, Amber R Hackett, Valeria Cavalli, Manuel Nieto-Diaz
Every spring, deer cast their old antlers and initiate a regeneration process, which yields a new set of antlers of up to 1m in length. Over the course of three months, branches of the trigeminal nerve, originating from the frontal skull, innervate velvet, a modified skin that covers the regenerating antler. The rate of growth of these axons reaches up to 2cm per day making them the fastest regenerating axons in adult mammals. Here, we aim to identify the factors secreted by velvet that promote such high speed axon growth...
November 4, 2016: Neuroscience
https://www.readbyqxmd.com/read/27816968/diagnostic-and-prognostic-value-of-serum-periostin-in-patients-with-non-small-cell-lung-cancer
#9
Chun-Hua Xu, Wei Wang, Yong Lin, Li-Hua Qian, Xiu-Wei Zhang, Qing-Bo Wang, Li-Ke Yu
The periostin protein is expressed in a variety of human malignancies. The aim of this study was to explore the diagnostic and prognostic value of serum periostin levels in patients with non-small cell lung cancer (NSCLC). We measured serum periostin levels by ELISA in 296 NSCLC patients, 120 benign lung diseases (BLD) patients and 160 healthy controls. The levels of serum periostin in NSCLC patients were significantly elevated compared with those in healthy controls (P < 0.001) and BLD patients (P < 0...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27809916/immunological-profiling-of-patients-with-ulcerative-colitis-leads-to-identification-of-two-inflammatory-conditions-and-cd1a-as-a-disease-marker
#10
M Föhlinger, P Palamides, U Mansmann, F Beigel, M Siebeck, R Gropp
BACKGROUND: Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed by verification of their roles in vitro and in vivo. In light of the highly dynamic processes in UC, requiring the cross talk of immune cells, epithelial-, endothelial-, muscle cells and fibrocytes, this approach might neglect temporal and spatial connectivity of individually differing inflammatory responses...
November 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27802442/urinary-periostin-excretion-predicts-renal-outcome-in-iga-nephropathy
#11
Jin Ho Hwang, Jung Pyo Lee, Clara Tammy Kim, Seung Hee Yang, Jin Hyuk Kim, Jung Nam An, Kyung Chul Moon, Hajeong Lee, Yun Kyu Oh, Kwon Wook Joo, Dong Ki Kim, Yon Su Kim, Chun Soo Lim
BACKGROUND: Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN). METHODS: Of 399 patients from a glomerulonephritis cohort recruited between January 2009 and December 2014, 314 were enrolled...
November 1, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27784843/role-of-periostin-in-hepatocellular-carcinoma-the-importance-of-tumor-microenvironment
#12
EDITORIAL
Jung Il Lee
No abstract text is available yet for this article.
November 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27776343/estrogen-related-receptor-alpha-in-castration-resistant-prostate-cancer-cells-promotes-tumor-progression-in-bone
#13
Anais Fradet, Mathilde Bouchet, Carine Delliaux, Manon Gervais, Casina Kan, Claire Benetollo, Francesco Pantano, Geoffrey Vargas, Lamia Bouazza, Martine Croset, Yohann Bala, Xavier Leroy, Thomas J Rosol, Jennifer Rieusset, Akeila Bellahcène, Vincent Castronovo, Jane E Aubin, Philippe Clézardin, Martine Duterque-Coquillaud, Edith Bonnelye
Bone metastases are one of the main complications of prostate cancer and they are incurable. We investigated whether and how estrogen receptor-related receptor alpha (ERRα) is involved in bone tumor progression associated with advanced prostate cancer. By meta-analysis, we first found that ERRα expression is correlated with castration-resistant prostate cancer (CRPC), the hallmark of progressive disease. We then analyzed tumor cell progression and the associated signaling pathways in gain-of-function/loss-of-function CRPC models in vivo and in vitro...
October 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27771323/cross-talk-between-human-mast-cells-and-epithelial-cells-by-ige-mediated-periostin-production-in-eosinophilic-nasal-polyps
#14
Dae Woo Kim, Marianna Kulka, Ara Jo, Kyoung Mi Eun, Narcy Arizmendi, Brian P Tancowny, Seung-No Hong, Jung Pyo Lee, Hong Ryul Jin, Richard F Lockey, Dong-Kyu Kim, Seong H Cho
Periostin is up-regulated in E-NP and is associated with disease severity and Th2 inflammatory markers. Periostin was produced by IgE-stimulated mast cells. Secreted periostin binds to integrin αV on the epithelial cell surface and induces TSLP release from epithelial cells in E-NP.
October 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27751812/induction-of-fibrillin-2-and-periostin-expression-in-osterix-knockdown-mc3t3-e1-cells
#15
So-Jeong Lee, Eun-Hye Lee, Seung-Yoon Park, Jung-Eun Kim
Osteoporosis is the most common age-related bone disease that is characterized by an imbalance between osteoblasts for bone formation and osteoclasts for bone resorption. Anti-catabolic drugs have been developed to inhibit osteoclast activity and to prevent bone loss in osteoporosis. However, because it is difficult to increase bone mass in osteoporotic bone, it would be beneficial to simultaneously enhance osteoblast function and thus form bone. Osterix (Osx) is an essential transcription factor for osteoblast differentiation...
October 14, 2016: Gene
https://www.readbyqxmd.com/read/27751727/development-of-a-new-architect-automated-periostin-immunoassay
#16
Nicolette M Jeanblanc, Philip M Hemken, Maria J Datwyler, Susan E Brophy, T Scott Manetz, Rozanne Lee, Meina Liang, Partha S Chowdhury, Reena Varkey, Ethan P Grant, Katie Streicher, Lydia Greenlees, Koustubh Ranade, Gerard J Davis
BACKGROUND: Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and analytic performance of the investigational use only Architect Periostin Immunoassay, a new automated assay developed to detect serum periostin concentrations. METHODS: We assessed assay performance in terms of precision, sensitivity, linearity, interference from classical immunoassay interferents and representatives of common asthma medications, specimen handling, and isoform reactivity...
October 14, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27744020/different-roles-played-by-periostin-splice-variants-in-retinal-neovascularization
#17
Takahito Nakama, Shigeo Yoshida, Keijiro Ishikawa, Yoshiyuki Kobayashi, Takaya Abe, Hiroshi Kiyonari, Go Shioi, Naruto Katsuragi, Tatsuro Ishibashi, Ryuichi Morishita, Yoshiaki Taniyama
Retinal neovascularization (NV) due to retinal ischemia is one of the major causes of vision reduction in patients with different types of retinal diseases although anti-vascular endothelial growth factor (anti-VEGF) therapy can partially reduce the size of the retinal NV. We recently reported that periostin plays an important role in the development of NV and the formation of preretinal fibrovascular membranes, but the role of the splice variants of periostin on retinal NV has not been determined. We examined the expressions of periostin splice variants in the ischemic retinas of a mouse model of oxygen-induced retinal NV...
October 12, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27742499/sclerostin-s-role-in-bone-s-adaptive-response-to-mechanical-loading
#18
Gabriel L Galea, Lance E Lanyon, Joanna S Price
Mechanical loading is the primary functional determinant of bone mass and architecture, and osteocytes play a key role in translating mechanical signals into (re)modelling responses. Although the precise mechanisms remain unclear, Wnt signalling pathway components, and the anti-osteogenic canonical Wnt inhibitor Sost/sclerostin in particular, play an important role in regulating bone's adaptive response to loading. Increases in loading-engendered strains down-regulate osteocyte sclerostin expression, whereas reduced strains, as in disuse, are associated with increased sclerostin production and bone loss...
October 12, 2016: Bone
https://www.readbyqxmd.com/read/27725167/multicenter-evaluation-of-analytical-characteristics-of-the-elecsys%C3%A2-periostin-immunoassay
#19
Stefan Palme, Robert H Christenson, Saeed A Jortani, Richard E Ostlund, Ruediger Kolm, Guido Kopal, Ruediger P Laubender
OBJECTIVE: The multifunctional cytokine IL-13 is thought to play a central role in Type 2 inflammation in asthma. Serum periostin has been explored as a candidate biomarker for evaluating IL-13 activity in the airway. We describe the technical performance characteristics of a novel, fully automated immunoassay for the determination of periostin in serum. DESIGN AND METHODS: Limit of blank [LoB], limit of detection [LoD] and limit of quantitation [LoQ], linearity, precision and reproducibility across sites and lots were evaluated according to Clinical and Laboratory Standards Institute guidelines...
October 8, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27716740/high-levels-of-periostin-correlate-with-increased-fracture-rate-diffuse-mri-pattern-abnormal-bone-remodeling-and-advanced-disease-stage-in-patients-with-newly-diagnosed-symptomatic-multiple-myeloma
#20
E Terpos, D Christoulas, E Kastritis, T Bagratuni, M Gavriatopoulou, M Roussou, A Papatheodorou, E Eleutherakis-Papaiakovou, N Kanellias, C Liakou, I Panagiotidis, M Migkou, P Kokkoris, L A Moulopoulos, M A Dimopoulos
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls...
October 7, 2016: Blood Cancer Journal
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