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Mismatch Negativity

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https://www.readbyqxmd.com/read/28725405/effects-of-food-abundance-and-early-clutch-predation-on-reproductive-timing-in-a-high-arctic-shorebird-exposed-to-advancements-in-arthropod-abundance
#1
Jeroen Reneerkens, Niels Martin Schmidt, Olivier Gilg, Jannik Hansen, Lars Holst Hansen, Jérôme Moreau, Theunis Piersma
Climate change may influence the phenology of organisms unequally across trophic levels and thus lead to phenological mismatches between predators and prey. In cases where prey availability peaks before reproducing predators reach maximal prey demand, any negative fitness consequences would selectively favor resynchronization by earlier starts of the reproductive activities of the predators. At a study site in northeast Greenland, over a period of 17 years, the median emergence of the invertebrate prey of Sanderling Calidris alba advanced with 1...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28719630/oligo-and-dsdna-mediated-genome-editing-using-a-teta-dual-selection-system-in-escherichia-coli
#2
Young Shin Ryu, Sathesh-Prabu Chandran, Kyungchul Kim, Sung Kuk Lee
The ability to precisely and seamlessly modify a target genome is needed for metabolic engineering and synthetic biology techniques aimed at creating potent biosystems. Herein, we report on a promising method in Escherichia coli that relies on the insertion of an optimized tetA dual selection cassette followed by replacement of the same cassette with short, single-stranded DNA (oligos) or long, double-stranded DNA and the isolation of recombinant strains by negative selection using NiCl2. This method could be rapidly and successfully used for genome engineering, including deletions, insertions, replacements, and point mutations, without inactivation of the methyl-directed mismatch repair (MMR) system and plasmid cloning...
2017: PloS One
https://www.readbyqxmd.com/read/28719467/pan-trk-immunohistochemistry-is-an-efficient-and-reliable-screen-for-the-detection-of-ntrk-fusions
#3
Jaclyn F Hechtman, Ryma Benayed, David M Hyman, Alexander Drilon, Ahmet Zehir, Denise Frosina, Maria E Arcila, Snjezana Dogan, David S Klimstra, Marc Ladanyi, Achim A Jungbluth
Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain tumors. Here, we explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-generation sequencing assay. Transcription of novel NTRK rearrangements into potentially functional fusion transcripts was assessed via Archer Dx fusion assay. Pan-Trk IHC testing with mAb EPR17341 was performed on all NTRK rearranged cases and 20 cases negative for NTRK fusions on Archer...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28715718/when-speaker-identity-is-unavoidable-neural-processing-of-speaker-identity-cues-in-natural-speech
#4
Alba Tuninetti, Kateřina Chládková, Varghese Peter, Niels O Schiller, Paola Escudero
Speech sound acoustic properties vary largely across speakers and accents. When perceiving speech, adult listeners normally disregard non-linguistic variation caused by speaker or accent differences, in order to comprehend the linguistic message, e.g. to correctly identify a speech sound or a word. Here we tested whether the process of normalizing speaker and accent differences, facilitating the recognition of linguistic information, is found at the level of neural processing, and whether it is modulated by the listeners' native language...
July 14, 2017: Brain and Language
https://www.readbyqxmd.com/read/28715228/mid-infrared-plasmonic-circular-dichroism-generated-by-graphene-nanodisk-assemblies
#5
Xiang-Tian Kong, Runbo Zhao, Zhiming Wang, Alexander O Govorov
It is very interesting to bring plasmonic circular dichroism spectroscopy to the mid-infrared spectral interval, and there are two reasons for this. This spectral interval is very important for thermal bioimaging, and simultaneously, this spectral range includes vibrational lines of many chiral biomolecules. Here we demonstrate that graphene plasmons indeed offer such opportunity. In particular, we show that chiral graphene assemblies consisting of a few graphene nanodisks can generate strong circular dichroism (CD) in the mid-infrared interval...
July 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28714944/impact-of-the-presence-of-hla-1-locus-mismatch-and-the-use-of-low-dose-antithymocyte-globulin-in-unrelated-bone-marrow-transplantation
#6
K Kawamura, J Kanda, S Fuji, M Murata, K Ikegame, K Yoshioka, T Fukuda, Y Ozawa, N Uchida, K Iwato, T Sakura, M Hidaka, H Hashimoto, T Ichinohe, Y Atsuta, Y Kanda
HLA 1-locus-mismatched unrelated donors (1MMUD) have been used in allogeneic hematopoietic stem cell transplantation (allo-HCT) for patients who lack an HLA-matched donor. We retrospectively analyzed 3313 patients with acute leukemia or myelodysplastic syndrome who underwent bone marrow transplantation from an HLA allele-matched unrelated donor (MUD) or 1MMUD between 2009 and 2014. We compared the outcomes of MUD (n=2089) and 1MMUD with antithymocyte globulin (ATG) (1MM-ATG(+); n=109) with those of 1MMUD without ATG (1MM-ATG(-); n=1115)...
July 17, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28713253/on-the-keyhole-hypothesis-high-mutual-information-between-ear-and-scalp-eeg
#7
Kaare B Mikkelsen, Preben Kidmose, Lars K Hansen
We propose and test the keyhole hypothesis-that measurements from low dimensional EEG, such as ear-EEG reflect a broadly distributed set of neural processes. We formulate the keyhole hypothesis in information theoretical terms. The experimental investigation is based on legacy data consisting of 10 subjects exposed to a battery of stimuli, including alpha-attenuation, auditory onset, and mismatch-negativity responses and a new medium-long EEG experiment involving data acquisition during 13 h. Linear models were estimated to lower bound the scalp-to-ear capacity, i...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28712970/cortical-responses-to-tone-and-phoneme-mismatch-as-a-predictor-of-dyslexia-a-systematic-review
#8
Susanne Volkmer, Gerd Schulte-Körne
Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) - an ERP component reflecting passive auditory change detection ability - has been found to be reduced, not only in children with a diagnosis of dyslexia, but also in infants and preschool children at risk of developing dyslexia. However, the results are controversial due to the different methods, age of the children and stimuli used...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28712341/genetic-analysis-of-bactrocera-zonata-diptera-tephritidae-populations-from-india-based-on-cox1-and-nad1-gene-sequences
#9
Jaipal S Choudhary, Naiyar Naaz, Moanaro Lemtur, Bikash Das, Arun Kumar Singh, Bhagwati P Bhatt, Chandra S Prabhakar
The peach fruit fly, Bactrocera zonata, is among the most serious and polyphagous insect pest of fruit crops in many parts of the world under genus Bactrocera. In the present study, the genetic structure, diversity and demographic history of B. zonata in India were inferred from mitochondrial cytochrome oxidase 1 (cox1) and NADH dehydrogenase 1 (nad1) sequences. The efficiency of DNA barcodes for identification of B. zonata was also tested. Genetic diversity indices [number of haplotypes (H), haplotype diversity (Hd), nucleotide diversity (π) and average number of nucleotide differences (k)] of B...
July 15, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28711476/treatment-in-early-psychosis-with-n-acetyl-cysteine-for-6months-improves-low-level-auditory-processing-pilot-study
#10
Chrysa Retsa, Jean-François Knebel, Eveline Geiser, Carina Ferrari, Raoul Jenni, Margot Fournier, Luis Alameda, Philipp S Baumann, Stephanie Clarke, Philippe Conus, Kim Q Do, Micah M Murray
Sensory impairments constitute core dysfunctions in schizophrenia. In the auditory modality, impaired mismatch negativity (MMN) has been observed in chronic schizophrenia and may reflect N-methyl-d-aspartate (NMDA) hypo-function, consistent with models of schizophrenia based on oxidative stress. Moreover, a recent study demonstrated deficits in the N100 component of the auditory evoked potential (AEP) in early psychosis patients. Previous work has shown that add-on administration of the glutathione precursor N-acetyl-cysteine (NAC) improves the MMN and clinical symptoms in chronic schizophrenia...
July 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28711472/interactive-effects-of-an-n-methyl-d-aspartate-receptor-antagonist-and-a-nicotinic-acetylcholine-receptor-agonist-on-mismatch-negativity-implications-for-schizophrenia
#11
Holly K Hamilton, Deepak C D'Souza, Judith M Ford, Brian J Roach, Naomi S Kort, Kyung-Heup Ahn, Savita Bhakta, Mohini Ranganathan, Daniel H Mathalon
N-methyl-d-aspartate glutamate receptor (NMDAR) hypofunction has been implicated in the pathophysiology of schizophrenia, including auditory processing abnormalities reflected by the mismatch negativity (MMN) event-related potential component. Evidence suggesting cognitive benefits from nicotine administration, together with the high rate of cigarette use in patients with schizophrenia, has stimulated interest in whether nicotine modulates NMDAR hypofunction. We examined the interactive effects of ketamine, an NMDAR antagonist that produces transient schizophrenia-like neurophysiological effects, and nicotine, a nicotinic acetylcholine receptor (nAChR) agonist, in 30 healthy volunteers to determine whether nicotine prevents or attenuates MMN abnormalities...
July 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28710556/visual-mismatch-negativity-vmmn-for-low-and-high-level-deviances-a-control-study
#12
Domonkos File, Bálint File, Flóra Bodnár, István Sulykos, Krisztina Kecskés-Kovács, István Czigler
The aim of our studies was to separate the effects of violating a sequential rule (genuine visual mismatch negativity; gvMMN) from the decreased activity in response to repeated stimuli (stimulus-specific adaptation; SSA) for simple and more complex stimuli. To accomplish this goal, different control procedures were applied with the aim of finding the correct control for vMMN studies. Event-related brain electric activity (ERPs) was measured in response to nonattended visual stimuli that were presented either in an oddball manner or in various control sequences...
July 14, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28709770/meta-analysis-of-mismatch-negativity-to-simple-versus-complex-deviants-in-schizophrenia
#13
Michael Avissar, Shanghong Xie, Blair Vail, Javier Lopez-Calderon, Yuanjia Wang, Daniel C Javitt
Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex deviants that violate more abstract rules to probe higher order cognitive deficits. It is still unclear how sensory processing deficits compare to and contribute to higher order cognitive dysfunction, which can be investigated with later attention-dependent auditory event-related potential (ERP) components such as a subcomponent of P300, P3b...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28701629/atypical-pituitary-adenoma-with-men1-somatic-mutation-associated-with-abnormalities-of-dna-mismatch-repair-genes-mlh1-germline-mutation-and-msh6-somatic-mutation
#14
Shinsuke Uraki, Hiroyuki Ariyasu, Asako Doi, Hiroto Furuta, Masahiro Nishi, Kokichi Sugano, Naoko Inoshita, Naoyuki Nakao, Shozo Yamada, Takashi Akamizu
The mechanism of pituitary tumorigenesis remains largely unknown. Lynch syndrome is an autosomal, dominantly inherited syndrome caused by a defective mismatch repair (MMR) mechanism involved in the development of various tumors at an early age. In this case study, we showed the occurrence of pituitary tumors associated with Lynch syndrome for the first time and performed genetic and immunohistochemical analysis to evaluate the genetic aberrations that might be related to the tumorigenesis and proliferation...
July 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28692453/neuromagnetic-evaluation-of-a-communication-support-system-for-hearing-impaired-patients
#15
Kei Nakagawa, Shinichiro Nakaishi, Takeshi Imura, Yumi Kawahara, Akira Hashizume, Kaoru Kurisu, Louis Yuge
Hearing-impaired patients often encounter obstacles in communication. Not all of them wear hearing aids, citing issues with usage difficulty and discomfort in wearing. To overcome these difficulties, a new endeavor was started to improve sound intelligibility from the speaker's side. The present study objectively evaluated an intelligible-hearing (IH) loudspeaker by means of magnetoencephalography. Magnetic counterparts of mismatch negativity (MMNm) to pronunciation ('mi' and 'ni') were recorded and compared when they were transmitted from the IH loudspeaker and from a normal-hearing loudspeaker...
August 16, 2017: Neuroreport
https://www.readbyqxmd.com/read/28690930/plant-pollinator-interactions-under-climate-change-the-use-of-spatial-and-temporal-transplants
#16
Eva M Morton, Nicole E Rafferty
Climate change is affecting both the timing of life history events and the spatial distributions of many species, including plants and pollinators. Shifts in phenology and range affect not only individual plant and pollinator species but also interactions among them, with possible negative consequences for both parties due to unfavorable abiotic conditions or mismatches caused by differences in shift magnitude or direction. Ultimately, population extinctions and reductions in pollination services could occur as a result of these climate change-induced shifts, or plants and pollinators could be buffered by plastic or genetic responses or novel interactions...
June 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28687908/the-effect-of-bilateral-transcranial-direct-current-stimulation-on-early-auditory-processing-in-schizophrenia-a-preliminary-study
#17
Walter Dunn, Yuri Rassovsky, Jonathan Wynn, Allan D Wu, Marco Iacoboni, Gerhard Hellemann, Michael F Green
Transcranial direct current stimulation (tDCS) was applied bilaterally over the auditory cortex in 12 schizophrenia patients to modulate early auditory processing. Performance on a tone discrimination task (tone-matching task-TMT) and auditory mismatch negativity were assessed after counterbalanced anodal, cathodal, and sham tDCS. Cathodal stimulation improved TMT performance (p < 0.03) compared to sham condition. Post-hoc analyses revealed a stimulation condition by negative symptom interaction in which greater negative symptoms were associated with a better TMT performance after anodal tDCS...
July 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28686681/kir-and-their-hla-class-i-ligands-two-more-pieces-towards-completing-the-puzzle-of-chronic-rejection-and-graft-loss-in-kidney-transplantation
#18
Roberto Littera, Gianbenedetto Piredda, Davide Argiolas, Sara Lai, Elena Congeddu, Paola Ragatzu, Maurizio Melis, Elisabetta Carta, Maria Benigna Michittu, Donatella Valentini, Luisella Cappai, Rita Porcella, Francesco Alba, Maria Serra, Valentina Loi, Roberta Maddi, Sandro Orrù, Giorgio La Nasa, Giovanni Caocci, Roberto Cusano, Marcella Arras, Mauro Frongia, Antonello Pani, Carlo Carcassi
BACKGROUND: Kidney transplantation is a life-saving treatment for patients with end-stage renal disease. However, despite progress in surgical techniques and patient management, immunological rejection continues to have a negative impact on graft function and overall survival. Incompatibility between donors and recipients for human leukocyte antigens (HLA) of the major histocompatibility complex (MHC) generates a series of complex cellular and humoral immune response mechanisms that are largely responsible for rejection and loss of graft function...
2017: PloS One
https://www.readbyqxmd.com/read/28684373/positive-cytotoxic-crossmatch-predicts-delayed-neutrophil-engraftment-in-allogeneic-hematopoietic-cell-transplantation-from-hla-mismatched-related-donors
#19
Kazuaki Kameda, Hideki Nakasone, Yusuke Komiya, Junya Kanda, Ayumi Gomyo, Jin Hayakawa, Yu Akahoshi, Masaharu Tamaki, Naonori Harada, Machiko Kusuda, Tomotaka Ugai, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Miki Sato, Aki Tanihara, Hidenori Wada, Kiriko Terasako-Saito, Misato Kikuchi, Shun-Ichi Kimura, Shinichi Kako, Yoshinobu Kanda
While positive cytotoxic crossmatch (XM) has been reported to predict graft failure, mainly in solid organ transplantations, the significance of positive XM in allogeneic hematopoietic cell transplantation (HCT) remains to be elucidated. We retrospectively assessed the impact of positive XM on neutrophil engraftment in 41 patients who received HCT from a human leukocyte antigen (HLA)-mismatched related donor. XM was positive in 22 patients. Among these 22 patients, 6 were also positive for anti-HLA antibody, while only 1 was positive for donor-specific anti-HLA antibody...
July 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28680490/auditory-evoked-potential-mismatch-negativity-in-normal-hearing-adults
#20
Laura Flach Schwade, Dayane Domeneghini Didoné, Pricila Sleifer
Introduction  Mismatch Negativity (MMN) corresponds to a response of the central auditory nervous system. Objective  The objective of this study is to analyze MMN latencies and amplitudes in normal-hearing adults and compare the results between ears, gender and hand dominance. Methods  This is a cross-sectional study. Forty subjects participated, 20 women and 20 men, aged 18 to 29 years and having normal auditory thresholds. A frequency of 1000Hz (standard stimuli) and 2000Hz (deviant stimuli) was used to evoked the MMN...
July 2017: International Archives of Otorhinolaryngology
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