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https://www.readbyqxmd.com/read/29161672/interpersonal-trauma-and-hoarding-the-mediating-role-of-aggression
#1
Brittany M Mathes, Amberly K Portero, Brittany A Gibby, Savannah L King, Amanda M Raines, Norman B Schmidt
BACKGROUND: A growing body of literature indicates that exposure to interpersonal trauma contributes to the onset or exacerbation of hoarding symptoms. However, little research has explored psychosocial factors that may help to explain the relationship between interpersonal trauma and hoarding symptoms. One outcome of trauma exposure that may be associated with hoarding symptoms is aggression, defined as the tendency to experience and express hostility and anger, and to engage in aggressive behavior...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161270/tracking-urban-human-activity-from-mobile-phone-calling-patterns
#2
Daniel Monsivais, Asim Ghosh, Kunal Bhattacharya, Robin I M Dunbar, Kimmo Kaski
Timings of human activities are marked by circadian clocks which in turn are entrained to different environmental signals. In an urban environment the presence of artificial lighting and various social cues tend to disrupt the natural entrainment with the sunlight. However, it is not completely understood to what extent this is the case. Here we exploit the large-scale data analysis techniques to study the mobile phone calling activity of people in large cities to infer the dynamics of urban daily rhythms. From the calling patterns of about 1,000,000 users spread over different cities but lying inside the same time-zone, we show that the onset and termination of the calling activity synchronizes with the east-west progression of the sun...
November 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29161153/protective-effects-of-agomelatine-on-testicular-damage-caused-by-bortezomib
#3
N Akaras, T Bal, H Atilay, J Selli, M B Halici
Bortezomib is a chemotherapeutic agent used to treat several cancers; however, it exhibits severe side effects in testicular tissue. We investigated the use of agomelatine to prevent testicular tissue damage caused by bortezomib. We used 36 male Sprague-Dawley rats divided randomly into six equal groups: group 1, no treatment control; group 2, agomelatine treatment only; group 3, bortezomib treatment only for 48 h; group 4, bortezomib + agomelatine treatment for 48 h; group 5, bortezomib treatment only for 72 h; and group 6, bortezomib + agomelatine treatment for 72 h...
November 21, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29161081/diet-obesity-and-asthma
#4
Lisa G Wood
Obesity has reached epidemic proportions in many developed countries as Western dietary patterns have been widely adopted. These diets are characterized by excess energy intake as well as regular consumption of processed or "fast" foods and limited consumption of fruit, vegetables, and whole grains. The result is a high intake of saturated fat, refined carbohydrates, and sodium; and a low intake of fiber, vitamins, and other phytochemicals. This type of poor-quality diet has been associated with increased risk of chronic inflammatory diseases, including asthma...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29160942/bioinspired-mesoporous-chiral-nematic-graphitic-carbon-nitride-for-ultrahigh-photocatalytic-activity-with-polarized-light-modulations
#5
Wensheng Lin, Wei Hong, Lu Sun, Di Yu, Dingshan Yu, Xudong Chen
Endowing materials with chirality and exploring the responses of the material under circularly polarized light (CPL) can gain further insight into the physical and chemical properties of the semiconductors, thus expand the optoelectronic applications. Herein we report a bioinspired mesoporous chiral nematic graphitic carbon nitride (g-C3N4) for efficient hydrogen evolutions with polarized light modulations based on chiral nematic cellulose nanocrystal films through silica templating. The mesoporous nematic chiral g-C3N4 exhibits an ultrahigh hydrogen evolution rate of 219...
November 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29160934/highly-efficient-perovskite-solar-cells-based-on-zn2ti3o8-nanoparticles-as-electron-transporting-material-with-efficiency-over-17
#6
Zhong-Ning Chen, Aiying Pang, Deli Shen, Mingdeng Wei
Developing ternary metal oxides as electron transporting layers (ETL) for perovskite solar cell is highly challenging in the field of third-generation photovoltaics. In this study, highly mesoporous zinc titanate oxide (Zn2Ti3O8) scaffold synthesized by ion-exchange method has been successfully used as ETL for the fabrication of methyl ammonium lead halide (CH3NH3PbI3) perovskite solar cells. The optimized devices exhibit 17.21% power conversion efficiency (PCE) with open circuit voltage (Voc) of 1.02 V, short-circuit current density (Jsc) of 21...
November 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29160881/effect-of-nobiletin-on-the-mapk-nf-%C3%AE%C2%BAb-signaling-pathway-in-the-synovial-membrane-of-rats-with-arthritis-induced-by-collagen
#7
Guliang Yang, Shiming Li, Li Yuan, Yiwen Yang, Min-Hsiung Pan
Nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) is a natural compound in the fruit peel of citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma lipids and has anti-oxidative properties. In studying the effect of nobiletin on rheumatoid arthritis (RA), the collagen-induced arthritis (CIA) model on Sprague-Dawley (SD) rats was established by bovine type II collagen (BIIC), and the effect of nobiletin on RA was investigated using hematoxylin-eosin (H&E) staining, serum enzyme linked immunosorbent assay (ELISA) detection and western blotting...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29160829/spatiotemporal-distribution-of-u5mr-and-their-relationship-with-geographic-and-socioeconomic-factors-in-china
#8
Zeng Li, Jingying Fu, Dong Jiang, Gang Lin, Donglin Dong, Xiaoxi Yan
Epidemiological studies conducted around the world have reported that the under-five mortality rate (U5MR) is closely associated with income and educational attainment. However, geographic elements should also remain a major concern in further improving child health issues, since they often play an important role in the survival environment. This study was undertaken to investigate the relationship between the U5MR, geographic, and socioeconomic factors, and to explore the associated spatial variance of the relationship in China using the geographically weighted regression (GWR) model...
November 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29160327/imbalance-in-amino-acid-and-purine-metabolisms-at-the-hypothalamus-in-inflammation-associated-depression-by-gc-ms
#9
Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Gao
Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression. However, little is known about the metabolomic changes in the hypothalamus of depressed patients with neuroinflammation. Herein, taking advantage of the well-established lipopolysaccharide (LPS)-induced depression mouse model, we measured metabolic changes in the hypothalamus using gas chromatography-mass spectrometry (GC-MS)...
November 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29160024/a-conceptual-framework-for-understanding-the-perspectives-on-the-causes-of-the-science-practice-gap-in-ecology-and-conservation
#10
Diana Bertuol-Garcia, Carla Morsello, Charbel N El-Hani, Renata Pardini
Applying scientific knowledge to confront societal challenges is a difficult task, an issue known as the science-practice gap. In Ecology and Conservation, scientific evidence has been seldom used directly to support decision-making, despite calls for an increasing role of ecological science in developing solutions for a sustainable future. To date, multiple causes of the science-practice gap and diverse approaches to link science and practice in Ecology and Conservation have been proposed. To foster a transparent debate and broaden our understanding of the difficulties of using scientific knowledge, we reviewed the perceived causes of the science-practice gap, aiming to: (i) identify the perspectives of ecologists and conservation scientists on this problem, (ii) evaluate the predominance of these perspectives over time and across journals, and (iii) assess them in light of disciplines studying the role of science in decision-making...
November 20, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29159850/from-two-to-three-dimensions-the-importance-of-the-third-dimension-for-evaluating-the-limits-to-neuronal-miniaturization-in-insects
#11
Stefan Fischer, Zhiyuan Lu, Ian A Meinertzhagen
Most studies dealing with the limits to miniaturization in insect brains have until now relied on information based on data collected in two dimensions: either histological sections imaged by light microscopy, or electron micrographs of single ultrathin sections imaged by transmission electron microscopy (TEM). To test the validity of transferring information gained from two-dimensional images to the third dimension, we examined a 3D image stack from serial-section TEM (ssTEM) of the optic neuropiles of the miniature parasitic wasp Trichogramma brassicae (Bezdenko, 1968)...
November 21, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29159723/anatomical-and-diffusional-determinants-inside-leaves-explain-the-difference-in-photosynthetic-capacity-between-cypripedium-and-paphiopedilum-orchidaceae
#12
Zhong-Hui Yang, Wei Huang, Qiu-Yun Yang, Wei Chang, Shi-Bao Zhang
Comparing with other angiosperms, most members within the family Orchidaceae have lower photosynthetic capacities. However, the underlying mechanisms remain unclear. Cypripedium and Paphiopedilum are closely related phylogenetically in Orchidaceae, but their photosynthetic performances are different. We explored the roles of internal anatomy and diffusional conductance in determining photosynthesis in three Cypripedium and three Paphiopedilum species, and quantitatively analyzed their diffusional and biochemical limitations to photosynthesis...
November 20, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29159705/isopropyl-quinoxaline-7-carboxylate-1-4-di-n-oxide-derivatives-induce-regulated-necrosis-like-cell-death-on-leishmania-leishmania-mexicana
#13
Karla Fabiola Chacón-Vargas, Sergio Andrade-Ochoa, Benjamín Nogueda-Torres, Dulce Carolina Juárez-Ramírez, Edgar E Lara-Ramírez, Ricardo Mondragón-Flores, Antonio Monge, Gildardo Rivera, Luvia Enid Sánchez-Torres
Leishmaniasis is a neglected tropical disease caused by the parasite of the genus Leishmania. About 13 million people are infected worldwide, and it is estimated that 350 million are at risk of infection. Clinical manifestations depend on the parasite species and factors related to the host such as the immune system, nutrition, housing, and financial resources. Available treatments have severe side effects; therefore, research currently focuses on finding more active and less toxic compounds. Quinoxalines have been described as promising alternatives...
November 20, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#14
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158602/radiative-control-of-dark-excitons-at-room-temperature-by-nano-optical-antenna-tip-purcell-effect
#15
Kyoung-Duck Park, Tao Jiang, Genevieve Clark, Xiaodong Xu, Markus B Raschke
Excitons, Coulomb-bound electron-hole pairs, are elementary photo-excitations in semiconductors that can couple to light through radiative relaxation. In contrast, dark excitons (XD) show anti-parallel spin configuration with generally forbidden radiative emission. Because of their long lifetimes, these dark excitons are appealing candidates for quantum computing and optoelectronics. However, optical read-out and control of XD states has remained challenging due to their decoupling from light. Here, we present a tip-enhanced nano-optical approach to induce, switch and programmably modulate the XD emission at room temperature...
November 20, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29158265/topical-mevastatin-promotes-wound-healing-by-inhibiting-the-transcription-factor-c-myc-via-the-glucocorticoid-receptor-and-the-long-noncoding-rna-gas5
#16
Andrew P Sawaya, Irena Pastar, Olivera Stojadinovic, Sonja Lazovic, Stephen C Davis, Joel Gil, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFU), a life-threatening complication of diabetes mellitus, have limited treatment options, often resulting in amputations. HMG-CoA reductase inhibitors such as statins are cholesterol-reducing agents that may provide a new therapeutic option. Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR). Here we demonstrate that the naturally occurring statin, mevastatin, reverses FPP's effects and promotes healing by using in vitro wound healing assays, human ex vivo and porcine in vivo wound models, and DFU tissue...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29157418/perceptual-episodes-temporal-attention-and-the-role-of-cognitive-control-lessons-from-the-attentional-blink
#17
Guy Snir, Yaffa Yeshurun
The ability to identify a target is usually hindered if it appears shortly after another target. This simple and somewhat intuitive observation is qualified by a multitude of unexpected findings and conflicting theories that originate from the attentional blink paradigm. In this review, the major results, implications, and outstanding questions that stem from the paradigm are presented and discussed. The extant literature suggests that when the temporal domain is densely stacked with numerous stimuli, the entities that underlie attentional selection and cognitive control are brief perceptual episodes...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29156774/micrornas-as-predictors-for-cns-relapse-of-systemic-diffuse-large-b-cell-lymphoma
#18
Nir Pillar, Osnat Bairey, Neta Goldschmidt, Yakov Fellig, Yevgenia Rosenblat, Itchak Shehtman, Danielle Haguel, Pia Raanani, Noam Shomron, Tali Siegal
Systemic diffuse large B-cell lymphoma (DLBCL) is a potentially curable disease using current regimen of immunochemotherapy. Central nervous system (CNS) relapse is a complication that occurs in approximately 5% of DLBCL patients and is associated with a high fatality rate. Early identification of molecular markers for CNS involvement may serve for the highly needed accurate stratification of patients into risk groups regarding CNS relapse. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and are known to be involved in DLBCL pathophysiology...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156706/mkrn3-functions-as-a-novel-ubiquitin-e3-ligase-to-inhibit-nptx1-during-puberty-initiation
#19
Huifang Liu, Xiangxin Kong, Fengling Chen
Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc Ring finger domain is considered as a putative E3 ubiquitin ligase, its actual function is never reported. Here, our results demonstrated that in mice hypothalamus before and when puberty initiated, Mkrn3 expressed the reversed tendency with Nptx1, which is an important secreted protein for neuron development...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156591/plasmonic-spectral-splitting-in-ring-rod-metasurface
#20
Naseer Muhammad, Adnan Daud Khan, Zi-Lan Deng, Karim Khan, Ashish Yadav, Qiang Liu, Zhengbiao Ouyang
We report spectral splitting behaviors based on Fano resonances in a novel simple planar metasurface composed of gold nanobars and nanorings. Multiple plasmonic modes and sharp Fano effects are achieved in a broadband transmittance spectrum by exploiting the rotational symmetry of the metasurface. The transmission properties are effectively modified and tuned by modulating the structural parameters. The highest single side Q-factor and FoM which reaches 196 and 105 are observed at Fano resonances. Our proposed design is relatively simple and can be applied for various applications such as multi-wavelength highly sensitive plasmonic sensors, switching, and slow light devices...
November 19, 2017: Nanomaterials
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