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https://www.readbyqxmd.com/read/27933582/microrna-181c-ameliorates-cognitive-impairment-induced-by-chronic-cerebral-hypoperfusion-in-rats
#1
Chen Fang, Qian Li, Guowen Min, Min Liu, Jing Cui, Jing Sun, Liang Li
Chronic cerebral hypoperfusion (CCH) characterized by global cerebral ischemia is an important risk factor contributing to the development of dementia. MicroRNAs (miRNAs) play important roles in the cellular adaptation to long-term ischemia/hypoxia by turning off or on the expression of target genes. MiR-181c is widely expressed in the nervous system, and tripartite motif 2 (TRIM2) is one of its target genes. In this work, we had identified that progressive spatial memory deficiency was induced in the bilateral common carotid artery occlusion (2-VO) rat models...
December 8, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27933112/osteoblast-and-stem-cell-response-to-nanoscale-topographies-a-review
#2
Nur Izzati Aminuddin, Roslina Ahmad, Sheikh Ali Akbar, Belinda Pingguan-Murphy
To understand how cells respond to the nanoscale extracellular environment in vivo, cells from various sources have been cultured on nanoscale patterns fabricated using bottom-up and top-down techniques. Human fetal osteoblasts (hFOBs) and stem cells are some of them and they are known to be overtly responsive to nanoscale topographies - allowing us to investigate the hows and whys of the response in vitro. Information gathered from these in vitro studies could be used to control the cells, i.e. make the stem cells differentiate or retain their characteristics without the use of medium supplements...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27933109/functional-characterization-of-rare-foxp2-variants-in-neurodevelopmental-disorder
#3
Sara B Estruch, Sarah A Graham, Swathi M Chinnappa, Pelagia Deriziotis, Simon E Fisher
BACKGROUND: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encodes a transcription factor with a forkhead box DNA-binding domain, but little is known about the functions of protein regions outside this domain. METHODS: We performed detailed functional analyses of seven rare FOXP2 variants found in affected cases, including three which have not been previously characterized, testing intracellular localization, transcriptional regulation, dimerization, and interaction with other proteins...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27933083/the-sclerophyllous-eucalyptus-camaldulensis-and-herbaceous-nicotiana-tabacum-have-different-mechanisms-to-maintain-high-rates-of-photosynthesis
#4
Wei Huang, You-Gui Tong, Guo-Yun Yu, Wei-Xian Yang
It is believed that high levels of mesophyll conductance (gm) largely contribute to the high rates of photosynthesis in herbaceous C3 plants. However, some sclerophyllous C3 plants that display low levels of gm have high rates of photosynthesis, and the underlying mechanisms responsible for high photosynthetic rates in sclerophyllous C3 plants are unclear. In the present study, we examined photosynthetic characteristics in two high-photosynthesis plants (the sclerophyllous Eucalyptus camaldulensis and the herbaceous Nicotiana tabacum) using measurements of gas exchange and chlorophyll fluorescence...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27933073/mistletoe-berry-outline-mapping-with-a-path-curve-function-and-recording-the-circadian-rhythm-of-their-phenotypic-shape-change
#5
Renatus Derbidge, Stephan Baumgartner, Peter Heusser
This paper presents a discovery: the change of the outline shape of mistletoe (Viscum album ssp. album) berries in vivo and in situ during ripening. It was found that a plant organ that is usually considered to merely increase in size actually changes shape in a specific rhythmic fashion. We introduce a new approach to chronobiological research on a macro-phenotypic scale to trace changes over long periods of time (with a resolution from hours to months) by using a dynamic form-determining parameter called Lambda (λ)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27933070/transcriptional-responses-in-root-and-leaf-of-prunus-persica-under-drought-stress-using-rna-sequencing
#6
Najla Ksouri, Sergio Jiménez, Christina E Wells, Bruno Contreras-Moreira, Yolanda Gogorcena
Prunus persica L. Batsch, or peach, is one of the most important crops and it is widely established in irrigated arid and semi-arid regions. However, due to variations in the climate and the increased aridity, drought has become a major constraint, causing crop losses worldwide. The use of drought-tolerant rootstocks in modern fruit production appears to be a useful method of alleviating water deficit problems. However, the transcriptomic variation and the major molecular mechanisms that underlie the adaptation of drought-tolerant rootstocks to water shortage remain unclear...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27933050/an-essential-factor-for-high-mg-2-tolerance-of-staphylococcus-aureus
#7
Joshua Armitano, Peter Redder, Vanessa A Guimarães, Patrick Linder
Internal bacterial concentration of Mg(2+), the most abundant divalent cation in living cells, is estimated to be in the single millimolar range. However, many bacteria will thrive in media with only micromolars of Mg(2+), by using a range of intensely studied and highly efficient import mechanisms, as well as in media with very high magnesium concentration, presumably mediated by currently unknown export mechanisms. Staphylococcus aureus has a particularly high Mg(2+) tolerance for a pathogen, growing unimpaired in up to 770 mM Mg(2+), and we here identify SA0657, a key factor in this tolerance...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27931218/scutellaria-barbata-flavonoids-alleviate-memory-deficits-and-neuronal-injuries-induced-by-composited-a%C3%AE-in-rats
#8
Xiao G Wu, Shu S Wang, Hong Miao, Jian J Cheng, Shu F Zhang, Ya Z Shang
BACKGROUND: The aim of the present study was to investigate the effects of Scutellaria barbata flavonoids (SBF) on memory impairment and neuronal injury induced by amyloid beta protein 25-35 in combination with aluminum trichloride (AlCl3) and recombinant human transforming growth factor-β1 (RHTGF-β1) (composited Aβ) in rats. METHODS: The composited Aβ-treated model of Alzheimer's disease (AD)-like memory impairment and neuronal injury was established in male rats by right intracerebroventricular injection of composited Aβ, and the effects of SBF were assessed using this rat model...
December 8, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27931190/daily-rhythmicity-of-clock-gene-transcript-levels-in-fast-and-slow-muscle-fibers-from-chinese-perch-siniperca-chuatsi
#9
Ping Wu, Yu-Long Li, Jia Cheng, Lin Chen, Xin Zhu, Zhi-Guo Feng, Jian-She Zhang, Wu-Ying Chu
BACKGROUND: Clock genes are considered to be the molecular core of biological clock in vertebrates and they are directly involved in the regulation of daily rhythms in vertebrate tissues such as skeletal muscles. Fish myotomes are composed of anatomically segregated fast and slow muscle fibers that possess different metabolic and contractile properties. To date, there is no report on the characterization of the circadian clock system components of slow muscles in fish. RESULTS: In the present study, the molecular clock components (clock, arntl1/2, cry1/2/3, cry-dash, npas2, nr1d1/2, per1/2/3, rorα and tim genes) and their daily transcription levels were characterized in slow and fast muscles of Chinese perch (Siniperca chuatsi)...
December 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27931134/constitutive-activation-of-alternative-nuclear-factor-kappa-b-pathway-in-canine-diffuse-large-b-cell-lymphoma-contributes-to-tumor-cell-survival-and-is-a-target-of-new-adjuvant-therapies
#10
Davis M Seelig, Daisuke Ito, Colleen L Forster, Una A Yoon, Matthew Breen, Linda J Burns, Veronika Bachanova, Kerstin Lindblad-Toh, Timothy D O'Brien, Stephen C Schmechel, Anthony E Rizzardi, Jaime F Modiano, Michael A Linden
Activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway is a common molecular event observed in both human and canine diffuse large B-cell lymphoma (DLBCL). Although the oncogenic potential of the alternative NFκB pathway (ANFκBP) has also been recently identified in DLBCL, its precise role in tumor pathogenesis and potential as a treatment target is understudied. We hypothesized that up-regulation of the ANFκBP plays an important role in the proliferation and survival of canine DLBCL cells, and we demonstrate that the ANFκBP is constitutively active in primary canine DLBCL samples and a cell line (CLBL1)...
December 8, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27930677/de-novo-sequencing-and-comparative-analysis-of-schima-superba-seedlings-to-explore-the-response-to-drought-stress
#11
Bao-Cai Han, Wei Wei, Xiang-Cheng Mi, Ke-Ping Ma
Schima superba is an important dominant species in subtropical evergreen broadleaved forests of China, and plays a vital role in community structure and dynamics. However, the survival rate of its seedlings in the field is low, and water shortage could be a factor that limits its regeneration. In order to better understand the response of its seedlings to drought stress on a functional genomics scale, RNA-seq technology was utilized in this study to perform a large-scale transcriptome sequencing of the S. superba seedlings under drought stress...
2016: PloS One
https://www.readbyqxmd.com/read/27929660/sensory-sensitivity-in-operation-enduring-freedom-operation-iraqi-freedom-veterans-with-and-without-blast-exposure-and-mild-traumatic-brain-injury
#12
Megan L Callahan, Laurence M Binder, Maya E O'Neil, Belle Zaccari, Mai S Roost, Shahrokh Golshan, Marilyn Huckans, Jesse R Fann, Daniel Storzbach
To examine factors associated with noise and light sensitivity among returning Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans with a self-reported history of mild traumatic brain injury (mTBI) due to blast exposure, we compared the self-report of noise and light sensitivity of 42 OEF/OIF Veterans diagnosed with mTBI resulting from combat blast-exposure to that of 36 blast-exposed OEF/OIF Veterans without a history of mTBI. Results suggest a statistically significant difference between Veterans with and without a history of mTBI in the experience of noise and light sensitivity, with sensory symptoms reported most frequently in the mTBI group...
December 8, 2016: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/27929447/predicting-driver-behavior-during-the-yellow-interval-using-video-surveillance
#13
Juan Li, Xudong Jia, Chunfu Shao
At a signalized intersection, drivers must make a stop/go decision at the onset of the yellow signal. Incorrect decisions would lead to red light running (RLR) violations or crashes. This study aims to predict drivers' stop/go decisions and RLR violations during yellow intervals. Traffic data such as vehicle approaching speed, acceleration, distance to the intersection, and occurrence of RLR violations are gathered by a Vehicle Data Collection System (VDCS). An enhanced Gaussian Mixture Model (GMM) is used to extract moving vehicles from target lanes, and the Kalman Filter (KF) algorithm is utilized to acquire vehicle trajectories...
December 6, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27928822/-solanum-tuberosum-zpr1-encodes-a-light-regulated-nuclear-dna-binding-protein-adjusting-the-circadian-expression-of-stbbx24-to-light-cycle
#14
Agnieszka Kiełbowicz-Matuk, Jagoda Czarnecka, Ewa Banachowicz, Pascal Rey, Tadeusz Rorat
ZPR1 proteins belong to the C4-type of zinc finger coordinators known in animal cells to interact with other proteins and participate in cell growth and proliferation. In contrast, the current knowledge regarding plant ZPR1 proteins is very scarce. Here, we identify a novel potato nuclear factor belonging to this family and named StZPR1. StZPR1 is specifically expressed in photosynthetic organs during the light period and the ZPR1 protein is located in the nuclear chromatin fraction. Based on modeling and experimental analyses, we reveal the StZPR1 ability to bind the circadian DNA cis motif 'CAACAGCATC', named CIRC and present in the promoter of the clock-controlled double B-box StBBX24 gene, the expression of which peaks in the middle of the day...
December 8, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27927864/efficacy-and-safety-of-praziquantel-against-light-infections-of-opisthorchis-viverrini-a-randomised-parallel-single-blind-dose-ranging-trial
#15
Somphou Sayasone, Isabel Meister, Jason R Andrews, Peter Odermatt, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Isaac I Bogoch, Jennifer Keiser
BACKGROUND: The liver fluke Opisthorchis viverrini, highly prevalent in Southeast Asia, is an important public health burden, including a risk factor for developing an aggressive bile duct cancer, cholangiocarcinoma, in chronically infected patients. Praziquantel, administered at single 40 mg/kg in preventive chemotherapy programs and 3 x 25 mg/kg for individual treatment is the drug of choice, yet information on the nature of the dose-response relationship is lacking. METHODS: We performed a randomized, parallel, single blind dose-ranging Phase 2 trial in Lao PDR in O...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27926928/an-interactome-centered-protein-discovery-approach-reveals-novel-components-involved-in-mitosome-function-and-homeostasis-in-giardia-lamblia
#16
Samuel Rout, Jon Paulin Zumthor, Elisabeth M Schraner, Carmen Faso, Adrian B Hehl
Protozoan parasites of the genus Giardia are highly prevalent globally, and infect a wide range of vertebrate hosts including humans, with proliferation and pathology restricted to the small intestine. This narrow ecological specialization entailed extensive structural and functional adaptations during host-parasite co-evolution. An example is the streamlined mitosomal proteome with iron-sulphur protein maturation as the only biochemical pathway clearly associated with this organelle. Here, we applied techniques in microscopy and protein biochemistry to investigate the mitosomal membrane proteome in association to mitosome homeostasis...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926582/differential-procoagulant-activity-of-microparticles-derived-from-monocytes-granulocytes-platelets-and-endothelial-cells-impact-of-active-tissue-factor
#17
Olga N Shustova, Olga A Antonova, Nina V Golubeva, Svetlana G Khaspekova, Vladimir V Yakushkin, Svetlana A Aksuk, Irina B Alchinova, Mikhail Y Karganov, Alexey V Mazurov
Microparticles released by activated/apoptotic cells exhibit coagulation activity as they express phosphatidylserine and some of them - tissue factor. We compared procoagulant properties of microparticles from monocytes, granulocytes, platelets and endothelial cells and assessed the impact of tissue factor in observed differences. Microparticles were sedimented (20 000g, 30 min) from the supernatants of activated monocytes, monocytic THP-1 cells, granulocytes, platelets and endothelial cells. Coagulation activity of microparticles was examined using plasma recalcification assay...
December 6, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27925216/light-regulation-of-alternative-pre-mrna-splicing-in-plants
#18
Hangxiao Zhang, Chentao Lin, Lianfeng Gu
Alternative splicing (AS) is a major post-transcriptional mechanism to enhance the diversity of proteome in response to environmental signals. Among the numerous external signals perceived by plants, light is the most crucial one. Plants utilize complex photoreceptor signaling networks to sense different light conditions and adjust their growth and development accordingly. Although light-mediated gene expression has been widely investigated, little is known regarding the mechanism of light affecting AS to modulate mRNA at the post-transcriptional level...
December 7, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27924857/electrohydrodynamic-assisted-assembly-of-hierarchically-structured-3d-crumpled-nanostructures-for-efficient-solar-conversions
#19
Hidetaka Ishihara, Yen-Chang Chen, Nicholas De Marco, Oliver Lin, Chih-Meng Huang, Vipawee Limsakoune, Yi-Chia Chou, Yang Yang, Vincent Tung
The tantalizing prospect of harnessing the unique properties of graphene crumpled nanostructures continues to fuel tremendous interest in energy storage and harvesting applications. However, the paper ball-like, hard texture, and closed-sphere morphology of current 3D graphitic nanostructure production not only constricts the conductive pathways but also limits the accessible surface area. Here, we report new insights into electrohydrodynamically-generated droplets as colloidal nanoreactors in that the stimuli-responsive nature of reduced graphene oxide can lead to the formation of crumpled nanostructures with a combination of open structures and doubly curved, saddle-shaped edges...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924844/designing-a-broadband-pump-for-high-quality-micro-lasers-via-modified-net-radiation-method
#20
Sergey Nechayev, Philip D Reusswig, Marc A Baldo, Carmel Rotschild
High-quality micro-lasers are key ingredients in non-linear optics, communication, sensing and low-threshold solar-pumped lasers. However, such micro-lasers exhibit negligible absorption of free-space broadband pump light. Recently, this limitation was lifted by cascade energy transfer, in which the absorption and quality factor are modulated with wavelength, enabling non-resonant pumping of high-quality micro-lasers and solar-pumped laser to operate at record low solar concentration. Here, we present a generic theoretical framework for modeling the absorption, emission and energy transfer of incoherent radiation between cascade sensitizer and laser gain media...
December 7, 2016: Scientific Reports
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