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https://www.readbyqxmd.com/read/29346004/universal-lead-screening-requirement-a-california-case-study
#1
Sara B McMenamin, Sarah P Hiller, Erin Shigekawa, Troy Melander, Riti Shimkhada
OBJECTIVES: To estimate potential impacts of California Assembly Bill (AB) 1316: a requirement for universal screening and insurance coverage for child blood lead testing. METHODS: In April 2017 the California Health Benefits Review Program (Oakland, CA) analyzed AB 1316 for the California legislature, including a systematic review of lead screening effectiveness, commercial insurer surveys regarding screening coverage, and actuarial utilization and cost implication assessments...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345154/trends-and-repetition-of-non-fatal-suicidal-behaviour-analyses-of-the-gold-coast-university-hospital-s-emergency-department
#2
Kairi Kõlves, David Crompton, Kathryn Turner, Nicolas J C Stapelberg, Ashar Khan, Gail Robinson, Diego de Leo
Objective The aim of the current paper is to analyse time trends of non-fatal suicidal behaviour (NFSB) and its repetition at the Gold Coast in 2005-2015. Methods Data on presentations for NFSB were obtained from the Emergency Department (ED) Information System. Potential cases were identified through keyword searches, which were further scrutinised and coded. Annual person-based age-standardised rates for NFSB were calculated. Chi-square test, Poisson regression and Cox proportional hazards regression were used...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29345026/male-male-aggression-is-unlikely-to-stabilize-a-poison-frog-polymorphism
#3
Yusan Yang, Matthew B Dugas, Houston J Sudekum, Sean Murphy, Corinne L Richards-Zawacki
Phenotypic polymorphism is common in animals, and the maintenance of multiple phenotypes in a population requires forces that act against homogenizing drift and selection. Male-male competition can contribute to the stability of a polymorphism when males compete primarily with males of the same phenotype. In and around a contact zone between red and blue lineages of the poison frog Oophaga pumilio, we used simulated territorial intrusions to test the non-exclusive predictions that males would direct more aggression toward males of (i) their own phenotype and/or (ii) the phenotype that is most common in their population...
January 18, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29344053/an-overview-of-exposure-to-ethanol-containing-substances-and-ethanol-intoxication-in-children-based-on-three-illustrated-cases
#4
REVIEW
Kam Lun Hon, Alexander Kc Leung, Eddie Cheung, Bryan Lee, Michelle Mc Tsang, Alcy R Torres
Alcohol addiction and intoxication are major health problems worldwide. Acute alcohol intoxication is well reported in adults and adolescents but less frequently reported in children of younger ages. We report three anonymized cases of pediatric ethanol exposure and illustrate the different mechanisms of intoxication. In all cases, a focused history is the key to prompt diagnosis and timely management. Physicians should be aware of this potential poison in children presented with acute confusional or encephalopathic state...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29343604/urbanization-and-anticoagulant-poisons-promote-immune-dysfunction-in-bobcats
#5
Laurel E K Serieys, Amanda J Lea, Marta Epeldegui, Tiffany C Armenta, Joanne Moriarty, Sue VandeWoude, Scott Carver, Janet Foley, Robert K Wayne, Seth P D Riley, Christel H Uittenbogaart
Understanding how human activities influence immune response to environmental stressors can support biodiversity conservation across increasingly urbanizing landscapes. We studied a bobcat (Lynx rufus) population in urban southern California that experienced a rapid population decline from 2002-2005 due to notoedric mange. Because anticoagulant rodenticide (AR) exposure was an underlying complication in mange deaths, we aimed to understand sublethal contributions of urbanization and ARs on 65 biochemical markers of immune and organ function...
January 31, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29343296/quantitative-method-for-analysis-of-six-anticoagulant-rodenticides-in-faeces-applied-in-a-case-with-repeated-samples-from-a-dog
#6
Kristin Opdal Seljetun, Elin Eliassen, Ritva Karinen, Lars Moe, Vigdis Vindenes
BACKGROUND: Accidental poisoning with anticoagulant rodenticides is not uncommon in dogs, but few reports of the elimination kinetics and half-lives in this species have been published. Our objectives were to develop and validate a new method for the quantification of anticoagulant rodenticides in canine blood and faeces using reversed phase ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and apply the method on a case of anticoagulant rodenticide intoxication...
January 17, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29342840/evaluation-of-rapid-early-warning-approaches-to-track-shellfish-toxins-associated-with-dinophysis-and-alexandrium-blooms
#7
Theresa K Hattenrath-Lehmann, Mark W Lusty, Ryan B Wallace, Bennie Haynes, Zhihong Wang, Maggie Broadwater, Jonathan R Deeds, Steve L Morton, William Hastback, Leonora Porter, Karen Chytalo, Christopher J Gobler
Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxin-producing Alexandrium and Dinophysis blooms on Long Island, NY, USA, which cause paralytic and diarrhetic shellfish poisoning (PSP and DSP), respectively. Within contrasting locations, the dynamics of pelagic Alexandrium and Dinophysis cell densities, toxins in plankton, and toxins in deployed blue mussels (Mytilus edulis) were compared with passive solid-phase adsorption toxin tracking (SPATT) samplers filled with two types of resin, HP20 and XAD-2...
January 13, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29340954/the-cultural-epigenesis-of-gender-based-violence-in-cambodia-local-and-buddhist-perspectives
#8
Maurice Eisenbruch
Almost one in four women in Cambodia is a victim of physical, emotional or sexual violence. The study aims to provide a comprehensive understanding of the ways in which Cambodians see its causes and effects and to identify and analyse the cultural forces that underpin and shape its landscape. An ethnographic study was carried out with 102 perpetrators and survivors of emotional, physical and sexual violence against women and 228 key informants from the Buddhist and healing sectors. Their views and experiences of it were recorded-the popular idioms expressed and the symptoms of distress experienced by survivors and perpetrators...
January 16, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29340871/neurotoxicity-of-prosopis-juliflora-from-natural-poisoning-to-mechanism-of-action-of-its-piperidine-alkaloids
#9
Victor Diogenes Amaral da Silva, André Mario Mendes da Silva, Juliana Helena Castro E Silva, Silvia Lima Costa
Prosopis juliflora was introduced in northeastern Brazil in the 1940s, and since then, it has been available as an alternative for animal nutrition. However, the consumption of P. juliflora as main or sole source of food causes an illness in animals known locally as "cara torta" disease. Cattle and goats experimentally intoxicated presents neurotoxic damage in the central nervous system. Histologic lesions were mainly characterized by vacuolation and loss of neurons in trigeminal motor nuclei. Furthermore, mitochondrial damage in neurons and gliosis was reported in trigeminal nuclei of intoxicated cattle...
January 16, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29340403/triangular-agau-pt-core-shell-nanoframes-with-a-dendritic-pt-shell-and-enhanced-electrocatalytic-performance-toward-the-methanol-oxidation-reaction
#10
Xiaoxiao Yan, Sijia Yu, Yawen Tang, Dongmei Sun, Lin Xu, Can Xue
Triangular AgAu@Pt nanoframes with a dendritic Pt shell were synthesized by employing Ag nanoprisms as sacrificial templates. Due to the unique frame-like nanostructure and ternary components, the AgAu@Pt nanoframes exhibit impressive electrocatalytic performance toward the methanol oxidation reaction with much higher activity, and better anti-poisoning capability than commercial Pt/C catalysts.
January 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29340013/the-small-molecule-si113-synergizes-with-mitotic-spindle-poisons-in-arresting-the-growth-of-human-glioblastoma-multiforme
#11
Claudia Abbruzzese, Giada Catalogna, Enzo Gallo, Simona di Martino, Anna M Mileo, Mariantonia Carosi, Vincenzo Dattilo, Silvia Schenone, Francesca Musumeci, Patrizia Lavia, Nicola Perrotti, Rosario Amato, Marco G Paggi
Glioblastoma multiforme (GBM) is the deadliest brain tumor. State-of-art GBM therapy often fails to ensure control of a disease characterized by high frequency of recurrences and progression. In search for novel therapeutic approaches, we assayed the effect of compounds from a cancer drug library on the ADF GBM cell line, establishing their elevated sensitivity to mitotic spindle poisons. Our previous work showed that the effectiveness of the spindle poison paclitaxel in inhibiting cancer cell growth was dependent on the expression of RANBP1, a regulatory target of the serine/threonine kinase SGK1...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338157/imbalance-of-th17-treg-in-the-pathogenesis-of-mice-with-paraquat-induced-acute-lung-injury
#12
Xia Yang, Jing-Hong Zhang, Jian-Feng Zhang, Hua Lin, Wei Chen, Li Xiang, Chao-Qian Li
Recent studies suggest that imbalances in the ratios of CD4+ T helper cell subsets, T helper-17 (Th17) and regulatory T (Treg) cells play a crucial role in the pathogenesis of acute lung injury (ALI). However, studies of the imbalance of Th17/Treg in paraquat (PQ)-induced ALI have not been reported. Therefore, we investigated whether the ratio of Th17/Treg cells in a mouse model of PQ-induced ALI contributes to pathogenesis of ALI. Male Kunming mice were randomly treated with saline (control group) or PQ (PQ-poisoned (PQP) group); mice were sacrificed at either 12 hours (PQP-12h) or 24 hours (PQP-24h and control) post-treatment...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29337924/effect-of-humid-aging-on-the-oxygen-adsorption-in-sno%C3%A2-gas-sensors
#13
Koichi Suematsu, Nan Ma, Ken Watanabe, Masayoshi Yuasa, Tetsuya Kida, Kengo Shimanoe
To investigate the effect of aging at 580 °C in wet air (humid aging) on the oxygen adsorption on the surface of SnO₂ particles, the electric properties and the sensor response to hydrogen in dry and humid atmospheres for SnO₂ resistive-type gas sensors were evaluated. The electric resistance in dry and wet atmospheres at 350 °C was strongly increased by humid aging. From the results of oxygen partial pressure dependence of the electric resistance, the oxygen adsorption equilibrium constants (K₁; for O- adsorption, K₂; for O2- adsorption) were estimated on the basis of the theoretical model of oxygen adsorption...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29336302/-cyclizine-is-sold-in-denmark-as-an-over-the-counter-drug-and-has-serious-side-effects-when-overdosed
#14
Kasper Petersen, Peter Hjorth
Cyclizine is sold in Denmark as an over-the-counter drug and affects not only histaminergic but also muscarinergic, serotonergic and α-adrenergic receptors, with side effects such as respiratory depression and cardiac arrhythmias, leading to fatalities. Due to the numerous side effects, it raises questions concerning the status of cyclizine as an over-the-counter drug. Data of healthcare contacts because of cyclizine intoxication in the 2014-2016 period should be analyzed to further illuminate the health risk of cyclizine poisoning...
January 15, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29336175/a-new-monoterpene-from-the-poisonous-mushroom-trogia-venenata-which-has-caused-sudden-unexpected-death-in-yunnan-province-china
#15
Ying-Chao Xu, Xiao-Xia Xie, Zhong-Yu Zhou, Tao Feng, Ji-Kai Liu
A new monoterpene, 6,7,8-trihydroxy-2,6-dimethyloctanoic acid (1), and a known sesquiterpene, β-caryophyllene 4R,5R-oxide (2), as well as four known ergosta-steroids, 5α,8α-epidioxyergosta-6,22-dien-3β-y1 linoleate (3), 3-O-β-D-glucopyranosyl-22E,24R-5α,8α-epidioxyergosta-6,22-dien (4), 5α,8α-epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (5) and (22E,24R)-ergosta-7,22-dien-3β-ol (6), were isolated from the fruiting bodies of the mushroom Trogia venenata. The structures of these compounds were identified by the analysis of spectral data...
January 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334816/anti-colchicine-fab-fragments-prevent-lethal-colchicine-toxicity-in-a-porcine-model-a-pharmacokinetic-and-clinical-study
#16
Michael Eddleston, Nicolas Fabresse, Adrian Thompson, Ibrahim Al Abdulla, Rachael Gregson, Tim King, Alain Astier, Frederic J Baud, R Eddie Clutton, Jean-Claude Alvarez
BACKGROUND: Colchicine poisoning is commonly lethal. Colchicine-specific Fab fragments increase rat urinary colchicine clearance and have been associated with a good outcome in one patient. We aimed to develop a porcine model of colchicine toxicity to study the pharmacokinetics and efficacy of ovine Fab. METHODS: A Göttingen minipig critical care model was established and serial blood samples taken for colchicine and Fab pharmacokinetics, clinical chemistry, and haematology...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29334809/accidental-pharmacological-poisonings-in-young-children-population-based-study-in-three-settings
#17
Jane C Bell, Jason P Bentley, Catriona Downie, Rose Cairns, Nicholas A Buckley, Annette Katelaris, Sallie-Anne Pearson, Natasha Nassar
INTRODUCTION: Pharmacological poisonings in young children are avoidable. Previous studies report calls to poisons centres, presentations to emergency departments (ED) or hospital admissions. There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals. METHODS: A population-based study in New South Wales, Australia, of PIC calls, ED presentations and hospital admissions for accidental pharmacological poisoning in children aged <5 years, 2007-2013...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29334268/analysis-of-the-development-and-progression-of-carbon-monoxide-poisoning-related-acute-kidney-injury-according-to-the-kidney-disease-improving-global-outcomes-kdigo-criteria
#18
Youn-Jung Kim, Chang Hwan Sohn, Dong-Woo Seo, Bum Jin Oh, Kyoung Soo Lim, Jai Won Chang, Won Young Kim
CONTEXT: Acute kidney injury (AKI) can occur after carbon monoxide (CO) intoxication; however, limited data are available. This study aimed to evaluate the prognostic value of the development and progression of AKI in patients with acute CO poisoning. MATERIALS AND METHODS: We conducted a retrospective cohort study using a prospective registry of CO poisoning between January 2010 and December 2015. AKI was defined and classified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29333835/-an-unintended-diagnosis-serotonergic-toxicity-secondary-to-drug-interactions-case-reports
#19
Elda G Cargnel, Patricia C Cardoso, Julián Irigoyen, Sol García Puglisi
Serotonin toxicity is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is seen with therapeutic medication use, intentional self-poisoning and inadvertent interactions (SSRI-isoniazid). Although this pathology is increasingly common, it is not well recognized by physicians and manifestations may be wrongly attributed to another cause. The aim of this paper is to describe the clinical picture of a patient, to collaborate on diagnosis and to improve medical care of these patients...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333659/acute-renal-replacement-therapy-during-hospitalization-is-training-adequate
#20
Paul M Palevsky
Acute renal replacement therapy is one of the most common interventions provided by nephrologists, however, data on the quality of training provided to nephrology fellows is limited. Extensive curricula for acute renal replacement therapy and the management of poisonings and intoxications have been published, but personal experience suggests that there are significant opportunities to improve training. Particular areas to be considered include the use of novel technologies for assessment of volume status, greater emphasis on the dosing of medications during acute renal replacement therapy, greater training in assessing and tailoring treatment to the goals of care of the individual patient, incorporation of continuous quality improvement tools into the management of acute renal replacement therapy programs and development of robust simulation training to augment training...
January 14, 2018: Seminars in Dialysis
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