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https://www.readbyqxmd.com/read/28239824/long-non-coding-rna-cche1-overexpression-predicts-a-poor-prognosis-for-cervical-cancer
#1
Y Chen, C-X Wang, X-X Sun, C Wang, T-F Liu, D-J Wang
OBJECTIVE: Our study is intended to explore the correlation of long non-coding RNA CCHE1 (CCHE1) and clinicopathological factors of cervical cancer patients, and evaluate the impact of CCHE1 on the prognosis of cervical cancer. PATIENTS AND METHODS: The CCHE1 expression in cervical cancer tissues was examined by quantitative Real-time PCR (qRT-PCR) and its correlation with clinicopathological features was also analyzed. A Kaplan-Meier survival curve was generated following a log-rank test...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239816/long-non-coding-rna-carlo-5-upregulation-associates-with-poor-prognosis-in-patients-suffering-gastric-cancer
#2
J-N Liu, Y-M Shangguan
OBJECTIVE: Accumulating evidence has demonstrated that microRNAs (miRNAs) play critical roles in cancer initiation and development. The present study aims to explore the clinical significance of long noncoding RNA CARLo-5 (CARLo-5) in gastric cancer. PATIENTS AND METHODS: CARLo-5 expression in normal gastric tissue, gastric cancer were quantified by Quantitative reverse transcription PCR. The relationship between CARLo-5 expression and the clinical features of gastric cancer was assessed...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239396/the-prognostic-value-of-baseline-lymphocyte-neutrophil-and-monocyte-counts-in-locally-advanced-cervical-carcinoma-treated-with-radiation
#3
Sareena Singh, Justin Himler, Christa I Nagel, Kimberly Resnick
Background. To determine the prognostic significance of pretreatment levels of circulating lymphocyte (CLC), neutrophil (CNC), and monocyte (CMC) counts in patients with locally advanced cervical carcinoma (CC) treated with definitive radiation. Methods. A retrospective, dual-institution review of patients with Stage IB2-IVA CC from 2005 to 2015. Progression-free (PFS) and Overall Survival (OS) were determined for high and low CLC, CNC, and CMC groups. Multivariate analysis was used to confirm prognostic value of baseline leukocyte counts...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28238354/optimal-primary-management-of-bulky-stage-iiic-ovarian-fallopian-tube-and-peritoneal-carcinoma-are-the-only-options-complete-gross-resection-at-primary-debulking-surgery-or-neoadjuvant-chemotherapy
#4
Vasileios D Sioulas, Maria B Schiavone, David Kadouri, Oliver Zivanovic, Kara Long Roche, Roisin O'Cearbhaill, Nadeem R Abu-Rustum, Douglas A Levine, Yukio Sonoda, Ginger J Gardner, Mario M Leitao, Dennis S Chi
OBJECTIVE: To explore the impact of primary debulking surgery (PDS) to minimal but gross residual disease (RD) in women with bulky stage IIIC ovarian, fallopian tube, or primary peritoneal cancer. METHODS: We retrospectively reviewed all patients with the aforementioned diagnosis who underwent PDS at our institution from 01/2001-12/2010. Those with disease of non-epithelial histology or borderline tumors were excluded. Clinicopathologic data were abstracted, and appropriate statistical tests were used...
February 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28238215/pretreatment-platelet-to-lymphocyte-ratio-is-associated-with-the-response-to-first-line-chemotherapy-and-survival-in-patients-with-metastatic-gastric-cancer
#5
Jin Wang, Jinglei Qu, Zhi Li, Xiaofang Che, Jing Liu, Yuee Teng, Bo Jin, Mingfang Zhao, Yunpeng Liu, Xiujuan Qu
BACKGROUND: Several studies have shown that platelet-to-lymphocyte ratio (PLR) is a prognostic factor for various cancers. However, there is no study about the role of PLR in predicting response to first-line chemotherapy of metastatic gastric cancer. Therefore, this study aimed to establish whether PLR is associated with the response to first-line chemotherapy and survival in patients with metastatic gastric cancer. METHODS: We enrolled 273 patients diagnosed with metastatic gastric cancer...
February 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28238166/the-effect-of-parathyroid-hormone-1-84-treatment-on-serum-bone-morphogenetic-protein-4-and-vascular-endothelial-growth-factor-in-postmenopausal-women-with-established-osteoporosis
#6
J Pepe, C Cipriani, F P Cantatore, A Fabbri, E Pola, V Vinicola, O Raimo, F Biamonte, R Pascone, C Ferrara, S Minisola
PURPOSE: To investigate the effect of 18 months' parathyroid hormone 1-84 (PTH 1-84) treatment on serum levels of bone morphogenetic protein 4 (BMP4) and vascular endothelial growth factor (VEGF), in postmenopausal women with established osteoporosis. METHODS: Thirty-seven postmenopausal women with osteoporosis (mean age 72.9 ± 8.1 years old) and 23 healthy controls (mean age 68.9 ± 9.9 years old) were enrolled. Patients were treated with daily subcutaneous injections of PTH (1-84) 100 mcg for 18 months, plus calcium 1 gr and vitamin D 800 IU per os daily...
February 25, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28238054/os-acromiale-frequency-and-a-review-of-726-shoulder-mri
#7
C Rovesta, M C Marongiu, A Corradini, P Torricelli, G Ligabue
Os acromiale consist in a lack of fusion between the different ossification spots of the acromial side of scapula from the age of 23-25 years. A relation between os acromiale and some shoulder pathology like impingement syndrome, cuff tear and subacromial bursitis has been described. The etiology is not already known. The aim of this study was to evaluate the frequency of os acromiale in our population, the link between os acromiale and sex, side and shoulder pathology. 1042 shoulder MRI were evaluated to find out os acromiale and the linked cuff pathology...
February 25, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28237868/a-pet-based-nomogram-for-oropharyngeal-cancers
#8
J Castelli, A Depeursinge, V Ndoh, J O Prior, M Ozsahin, A Devillers, H Bouchaab, E Chajon, R de Crevoisier, N Scher, F Jegoux, B Laguerre, B De Bari, J Bourhis
PURPOSE: In the context of locally advanced oropharyngeal cancer (LAOC) treated with definitive radiotherapy (RT) (combined with chemotherapy or cetuximab), the aims of this study were: (1) to identify PET-FDG parameters correlated with overall survival (OS) from a first cohort of patients; then (2) to compute a prognostic score; and (3) finally to validate this scoring system in a second independent cohort of patients. MATERIALS AND METHODS: A total of 76 consecutive patients (training cohort from Rennes) treated with chemoradiotherapy or RT with cetuximab for LAOC were used to build a predictive model of locoregional control (LRC) and OS based on PET-FDG parameters...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237753/tunable-and-purified-luminescence-via-energy-transfer-and-delamination-of-lrh-r-tb-y-composites-with-8-hydroxypyrene-1-3-6-trisulphonate
#9
Feifei Su, Chenyu Liu, Yan Yang, Shulan Ma, Genban Sun, Xiaojing Yang
This work demonstrates tunable and purified luminescence via one-step delamination of HPTS/OS-LRH composites (HPTS is trisodium 8-hydroxy-pyrene-1,3,6-trisulphonate, OS is sodium salt of 1-octane sulfonic acid, LRH is layered rare-earth hydroxide, R=Tb, Y) along with energy transfer. The HPTSxOS1-x-LTbyY1-yH composites presented varied luminescence behavior depending on their physical state. In solid state, dual-color luminescence was observed: blue-dominant emissions (437nm) for HPTSxOS1-x-LTbH, and blue- (437nm) to green-dominant (516nm) luminescence for HPTS0...
February 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28237182/correlation-of-c-met-expression-and-outcome-in-patients-with-renal-cell-carcinoma-treated-with-sunitinib
#10
Katriina Johanna Peltola, Patrick Penttilä, Juhana Rautiola, Heikki Joensuu, Erkki Hänninen, Ari Ristimäki, Petri Bono
BACKGROUND: Treatment of patients with metastatic renal cell carcinoma (mRCC) has improved substantially since the introduction of targeted therapies, but no predictive biomarkers are available. The proto-oncogene c-Met is involved in tumor angiogenesis, development, and metastasis. The main objective was to evaluate c-Met expression in sunitinib-treated patients with mRCC, including patients with bone metastases. METHODS: c-Met expression was analyzed from 137 formalin-fixed paraffin-embedded tumor samples using a validated immunostaining protocol...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28237180/plasma-cytokines-correlated-with-disease-characteristics-progression-free-survival-and-overall-survival-in-testicular-germ-cell-tumor%C3%A2-patients
#11
Daniela Svetlovska, Viera Miskovska, Dana Cholujova, Paulina Gronesova, Silvia Cingelova, Michal Chovanec, Zuzana Sycova-Mila, Jana Obertova, Patrik Palacka, Jan Rajec, Katarina Kalavska, Vanda Usakova, Jan Luha, Dalibor Ondrus, Stanislav Spanik, Jozef Mardiak, Michal Mego
BACKGROUND: Cytokines are the communicators of immune system and are involved in all immune responses. The aim of this study was to assess the correlation among plasma cytokines, patient and tumor characteristics, and clinical outcome in chemonaive testicular germ-cell tumor (TGCT) patients. PATIENTS AND METHODS: This study included 92 metastatic chemotherapy-naive TGCT patients treated with platinum-based chemotherapy from July 2010 to March 2014. Plasma was isolated before first administration of chemotherapy, and the concentration of 51 plasma cytokines were analyzed using multiplex bead arrays...
February 8, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28237055/influence-of-gender-and-race-ethnicity-on-perceived-barriers-to-help-seeking-for-alcohol-or-drug-problems
#12
Angie Denisse Otiniano Verissimo, Christine E Grella
This study examines reasons why people do not seek help for alcohol or drug problems by gender and race/ethnicity using data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative survey. Multivariate models were fit for 3 barriers to seeking help (structural, attitudinal, and readiness for change) for either alcohol or drug problems, controlling for socio-demographic characteristics and problem severity. Predicted probabilities were generated to evaluate gender differences by racial/ethnic subgroups...
April 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28236984/a-randomized-phase-ii-study-of-ly2510924-and-carboplatin-etoposide-versus-carboplatin-etoposide-in-extensive-disease-small-cell-lung-cancer
#13
Ravi Salgia, John R Stille, R Waide Weaver, Michael McCleod, Oday Hamid, John Polzer, Stephanie Roberson, Amy Flynt, David R Spigel
OBJECTIVES: This multicenter, open-label, randomized phase II study evaluated the efficacy and safety of LY2510924 (LY) added to first-line standard of care (SOC) chemotherapy for extensive-disease small cell lung cancer (ED-SCLC) and explored the predictive value of C-X-C motif receptor 4 (CXCR4) tumor response. MATERIALS AND METHODS: Patients with treatment-naïve ED-SCLC were randomized (1:1) to receive up to six 21-day cycles of carboplatin/etoposide alone (SOC) or in combination with 20mg LY2510924 administered subcutaneously on days 1-7 of each cycle (LY+SOC)...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236982/prognostic-and-predictive-value-of-loss-of-nuclear-rad51-immunoreactivity-in-resected-non-small-cell-lung-cancer-patients
#14
Mariam Gachechiladze, Josef Škarda, Vítězslav Kolek, Ivona Grygárková, Kateřina Langová, Jan Bouchal, Zdeněk Kolář, Florent Baty, Rolf Stahel, Walter Weder, Alex Soltermann, Markus Joerger
OBJECTIVES: In response to DNA damage, recombination proteins are relocalized into sub-nuclear complexes that are microscopically detected as RAD51-containing nuclear foci. We aimed for assessing the prognostic and predictive value of loss of nuclear RAD51 immunoreactivity ('RAD51 loss') in 2 independent stage I to III non-small cell lung cancer (NSCLC) patient cohorts undergoing surgical resection and eventual perioperative chemo-/radiotherapy (CT/RT). MATERIALS AND METHODS: The discovery set included 69 evaluable patients (19 adenocarcinomas, ADC, 50 squamous cell carcinomas, SCC) from Palacky University Hospital, 45/69 (65...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236981/phase-i-ii-study-of-tecemotide-as-immunotherapy-in-japanese-patients-with-unresectable-stage-iii-non-small-cell-lung-cancer
#15
Nobuyuki Katakami, Toyoaki Hida, Hiroshi Nokihara, Fumio Imamura, Hiroshi Sakai, Shinji Atagi, Makoto Nishio, Tatsuhiko Kashii, Miyako Satouchi, Christoph Helwig, Morihiro Watanabe, Tomohide Tamura
OBJECTIVES: Unresectable stage III NSCLC (non-small cell lung cancer) confers a poor prognosis and interest is growing in the use of immunotherapy to improve outcomes for patients with this disease. We investigated the safety and efficacy of maintenance tecemotide, a mucin 1 (MUC1)-specific agent that induces T-cell responses to MUC1, versus placebo in Japanese patients with stage III unresectable NSCLC and no disease progression after primary chemoradiotherapy. MATERIALS AND METHODS: Patients aged ≥20 years with unresectable stage III NSCLC, stable disease or clinical response after primary chemoradiotherapy and performance status ≤1, were recruited across 25 centers in Japan...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236980/significance-of-immune-checkpoint-proteins-in-egfr-mutant-non-small-cell-lung-cancer
#16
Ross A Soo, Hye Ryun Kim, Bernadette Reyna Asuncion, Zul Fazreen, Mohamed Feroz Mohd Omar, Maria Cynthia Herrera, Joey Sze Yun Lim, Grace Sia, Richie Soong, Byoung-Chul Cho
OBJECTIVES: To characterize the expression of PD-L1, PD-1, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T-cell immunoglobulin and mucin-domain containing-3 (TIM3) in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Samples from 90 patients with newly diagnosed advanced stage NSCLC harboring EGFR mutations and treated with first line EGFR tyrosine kinase inhibitors (TKI) within 3 months of diagnosis were stained for CTLA-4, PD-L1, PD-1, TIM-3 and CD3 expression by immunohistochemistry...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236768/survival-of-patients-with-melanoma-brain-metastasis-treated-with-stereotactic-radiosurgery-and-active-systemic-drug-therapies
#17
Ee Siang Choong, Serigne Lo, Martin Drummond, Gerald B Fogarty, Alexander M Menzies, Alexander Guminski, Brindha Shivalingam, Kathryn Clarke, Georgina V Long, Angela M Hong
INTRODUCTION: With new systemic therapies demonstrating activity in melanoma brain metastasis, most of the previously reported stereotactic radiosurgery (SRS) data are superseded. In this study, we report the outcomes (overall survival [OS] and brain control [BC]) and identify factors that associate with such outcomes in the era of modern systemic therapy. METHOD: A total of 108 patients treated with SRS from 2010 to 2015 were included. Systemic treatment use within 6 weeks of SRS was noted...
February 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28236368/treatment-related-determinants-of-survival-in-early-stage-t1-2n0m0-oral-cavity-cancer-a-population-based-study
#18
Justin C Sowder, Richard B Cannon, Luke O Buchmann, Jason P Hunt, Ying Hitchcock, Shane Lloyd, Kenneth F Grossmann, Marcus M Monroe
BACKGROUND: National guidelines support both surgical and radiotherapy (RT) as initial treatment options for early-stage oral cavity squamous cell carcinoma (SCC). There remains limited data evaluating the survival outcomes of RT and the current practice patterns for these lesions. METHODS: We conducted a retrospective review of 8274 patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with T1 to T2N0M0 oral cavity SCC. Primary outcomes were 5-year overall survival (OS) and disease-specific survival (DSS)...
February 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28236349/treatment-delays-in-oral-cavity-squamous-cell-carcinoma-and-association-with-survival
#19
Rance J T Fujiwara, Benjamin L Judson, Wendell G Yarbrough, Zain Husain, Saral Mehra
BACKGROUND: Treatment durations and factors associated with delays for oral cavity squamous cell carcinoma (SCC) have previously been described but are not fully understood. Impact of delays on overall survival (OS) remains unclear. METHODS: The National Cancer Data Base (NCDB) was used to analyze 4868 patients with oral cavity SCC from 1998 to 2011. Diagnosis-to-surgery, surgery-to-radiotherapy (RT)start , RT duration, total treatment package (surgery-to-RTend ), and diagnosis-to-RTend were evaluated...
February 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28236310/clomiphene-and-letrozole-for-reducing-fsh-consumption-during-ovarian-stimulation-systematic-review-and-meta-analysis
#20
REVIEW
Tatiana N B Marcal, Mariane N Nadai, Carolina O Nastri, Wellington P Martins
OBJECTIVE: to assess the available evidence comparing effectiveness of ovarian stimulation (OS) using clomiphene (CC) and/or letrozole (LTZ) for reducing FSH consumption compared with standard OS. METHODS: We performed a systematic review and meta-analyses of randomized controlled trials (RCTs) that compared the reproductive outcomes following in vitro fertilization. We searched eleven electronic databases and hand-searched the reference list of included studies and related reviews...
February 25, 2017: Ultrasound in Obstetrics & Gynecology
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