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https://www.readbyqxmd.com/read/29149697/characteristics-of-motor-speech-phenotypes-in-multiple-sclerosis
#1
Jan Rusz, Barbora Benova, Hana Ruzickova, Michal Novotny, Tereza Tykalova, Jan Hlavnicka, Tomas Uher, Manuela Vaneckova, Michaela Andelova, Klara Novotna, Lucie Kadrnozkova, Dana Horakova
BACKGROUND: Motor speech disorders in multiple sclerosis (MS) are poorly understood and their quantitative, objective acoustic characterization remains limited. Additionally, little data regarding relationships between the severity of speech disorders and neurological involvement in MS, as well as the contribution of pyramidal and cerebellar functional systems on speech phenotypes, is available. METHODS: Speech data were acquired from 141 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29143562/pathological-cut-offs-of-global-and-regional-brain-volume-loss-in-multiple-sclerosis
#2
Tomas Uher, Manuela Vaneckova, Jan Krasensky, Lukas Sobisek, Michaela Tyblova, Jana Volna, Zdenek Seidl, Niels Bergsland, Michael G Dwyer, Robert Zivadinov, Nicola De Stefano, Maria Pia Sormani, Eva Kubala Havrdova, Dana Horakova
BACKGROUND: Volumetric MRI surrogate markers of disease progression are lacking. OBJECTIVE: To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. METHODS: In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29143156/social-distance-and-community-attitudes-towards-people-with-psycho-social-disabilities-in-uttarakhand-india
#3
K Mathias, M Kermode, I Goicolea, L Seefeldt, R Shidhaye, M San Sebastian
Stigma is an important contributor to the large treatment gap for people with mental and psycho-social disabilities (PPSD) in India. Social distance as assessed by willingness to engage in relationships with PPSD is a proxy measure of stigma and potential discrimination. In North India, investigations of community attitudes towards PPSD have been limited. To describe attitudes towards people with depression and psychosis, a community sample of 960 adults in Dehradun district, India from 30 randomised clusters, was surveyed using a validated tool to assess social distance, beliefs and attitudes related to mental illness...
November 15, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29141795/validity-and-reliability-of-the-international-cooperative-ataxia-rating-scale-icars-and-the-scale-for-the-assessment-and-rating-of-ataxia-sara-in-multiple-sclerosis-patients-with-ataxia
#4
Yeliz Salcı, Ayla Fil, Hilal Keklicek, Barış Çetin, Kadriye Armutlu, Anıl Dolgun, Aslı Tuncer, Rana Karabudak
BACKGROUND: Ataxia is an extremely common problem in multiple sclerosis (MS) patients. Thus, appropriate scales are required for detailed assessment of this issue. The aim of our study was to investigate the reliability and validity of the Turkish version of the International Cooperative Ataxia Rating Scale (ICARS) and Scale for the Assessment and Rating of Ataxia (SARA), which are widely used in ataxia evaluation in the context of other cerebellar diseases. METHOD: This cross-sectional study included 80 MS patients with Kurtzke cerebellar functional system score (C-FSS) greater than zero and slight pyramidal involvement...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29137897/elevated-serum-levels-of-endothelin-1-in-patients-with-chronic-inflammatory-demyelinating-polyneuropathy
#5
Chun-Wei Chang, Hsiu-Chuan Wu, Rong-Kuo Lyu, Yen-Shi Lo, Chiung-Mei Chen, Long-Sun Ro, Hong-Shiu Chang, Ching-Chang Huang, Ming-Feng Liao, Yih-Ru Wu, Hong-Chou Kuo, Chun-Che Chu, Yi-Ching Weng, Pei-Tsi Wei, Ai-Lun Lo, Kuo-Hsuan Chang
INTRODUCTION: A Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired, or non-hereditary, chronic demyelinating neuropathy. Currently, there is no reliable molecular biomarker that can identify CIDP patients as well as monitor disease severity. MATERIAL AND METHODS: We measured serum levels of endothelin-1 (ET-1), a factors involved in vasoconstrictive, inflammatory and nerve regenerative processes, in the serum of 20 CIDP, 21 acute inflammatory demyelinating polyneuropathy (AIDP), 37 multiple sclerosis (MS), and 10 Alzheimer's disease (AD) patients, as well as 26 healthy control (HC) subjects...
November 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29124944/human-rights-of-refugee-survivors-of-sexual-and-gender-based-violence-with-communication-disability
#6
Julie Marshall, Helen Barrett
Article 19 of the Universal Declaration of Human Rights (United Nations, 1948 ) states that all people have the right to seek, receive and impart information using any means. Ensuring that people with communication disability achieve this right is inherently challenging. For people with communication disability, who are refugee-survivors of sexual and gender-based violence (SGBV), additional human rights are challenged, including the right to education, protection from discrimination, a safe place to live, security of person and legal protection...
November 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29122760/spinal-cord-gray-matter-atrophy-in-amyotrophic-lateral-sclerosis
#7
M-Ê Paquin, M M El Mendili, C Gros, S M Dupont, J Cohen-Adad, P-F Pradat
BACKGROUND AND PURPOSE: There is an emerging need for biomarkers to better categorize clinical phenotypes and predict progression in amyotrophic lateral sclerosis. This study aimed to quantify cervical spinal gray matter atrophy in amyotrophic lateral sclerosis and investigate its association with clinical disability at baseline and after 1 year. MATERIALS AND METHODS: Twenty-nine patients with amyotrophic lateral sclerosis and 22 healthy controls were scanned with 3T MR imaging...
November 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29107042/measuring-participation-after-stroke-in-africa-development-of-the-participation-measurement-scale
#8
Oyéné Kossi, Félix Nindorera, Charles Sèbiyo Batcho, Thierry Adoukonou, Massimo Penta, Jean-Louis Thonnard
OBJECTIVE: To develop a valid stroke-specific tool for the measurement of participation in Africa, named the Participation Measurement Scale (PM-Scale). DESIGN: Observational study and questionnaire development. SETTING: Outpatient Rehabilitation centers. PARTICIPANTS: Stroke patients (N = 276); mean age ± standard deviation of 58.5 ± 11.1 years; 57% male. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Participants completed a 100-item experimental questionnaire of the PM-Scale...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29102478/reliability-validity-and-minimal-detectable-change-of-the-push-off-test-scores-in-assessing-upper-extremity-weight-bearing-ability
#9
Saurabh P Mehta, Hannah R George, Christian A Goering, Danielle R Shafer, Alan Koester, Steven Novotny
STUDY DESIGN: Clinical measurement study. INTRODUCTION: The push-off test (POT) was recently conceived and found to be reliable and valid for assessing weight bearing through injured wrist or elbow. However, further research with larger sample can lend credence to the preliminary findings supporting the use of the POT. PURPOSE OF THE STUDY: This study examined the interrater reliability, construct validity, and measurement error for the POT in patients with wrist conditions...
November 1, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29079961/in-achilles-tendinopathy-the-neovascularization-detected-by-contrast-enhanced-ultrasound-ceus-is-abundant-but-not-related-to-symptoms
#10
Armanda De Marchi, Simona Pozza, Enzo Cenna, Franco Cavallo, Giorgia Gays, Luca Simbula, Paola De Petro, Alessandro Massè, Giuseppe Massazza
PURPOSE AND HYPOTHESIS: Mid-portion Achilles tendinopathy is characterized by a proliferation of small vessels, called neovascularization, which can be demonstrated by power Doppler sonography (PD). Neovascularization can be correlated with diagnosis and consequent therapies focused on vascular supply. Published data regarding the relationship between neovascularisation and symptoms, such as pain and disability, are contradictory. The hypothesis that contrast-enhanced ultrasound (CEUS) could detect with more sensibility than PD the new vessel ingrowth in human degenerated Achilles tendons and therefore the correlation of neovascularization with pain and disability, was evaluated...
October 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29078104/modeling-individual-variation-in-early-literacy-skills-in-kindergarten-children-with-intellectual-disabilities
#11
Arjan van Tilborg, Eliane Segers, Hans van Balkom, Ludo Verhoeven
In the present study, we investigated (i) to what extent the early literacy skills (phonological awareness, letter knowledge, and word decoding) along with cognitive (nonverbal reasoning, attention, phonological short-term memory, sequential memory, executive functioning) and linguistic (auditory discrimination, rapid naming, articulation, vocabulary) precursor measures of 53 six-year old children with intellectual disabilities (ID) differ from a group of 74 peers with normal language acquisition (NLA) and (ii) whether the individual variation of early literacy skills in the two groups to the same extent can be explained from the precursor measures...
October 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29070966/psychometric-properties-of-a-clinical-strength-assessment-protocol-in-people-with-multiple-sclerosis
#12
Mark M Mañago, Jeffrey R Hebert, Margaret Schenkman
BACKGROUND: Strength training in people with multiple sclerosis (MS) is an important component of rehabilitation, but it can be challenging for clinicians to quantify strength accurately and reliably. This study investigated the psychometric properties of a clinical strength assessment protocol using handheld dynamometry and other objective, quantifiable tests for the lower extremities and trunk in people with MS. METHODS: This study determined discriminant validity between 25 participants with MS and 25 controls and between participants with MS who had higher versus lower disability; test-retest reliability across 7 to 10 days; and response stability...
September 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/29063945/a-screening-tool-for-the-risk-of-disability-retirement-due-to-musculoskeletal-disorders
#13
Rahman Shiri, Markku Heliövaara, Kirsi Ahola, Leena Kaila-Kangas, Eija Haukka, Johanna Kausto, Peppiina Saastamoinen, Päivi Leino-Arjas, Tea Lallukka
Objective This study aimed to develop and validate a risk screening tool using a points system to assess the risk of future disability retirement due to musculoskeletal disorders (MSD). Methods The development population, the Health 2000 Survey, consisted of a nationally representative sample of Finnish employees aged 30-60 years (N=3676) and the validation population, the Helsinki Health Study, consisted of employees of the City of Helsinki aged 40-60 years (N=6391). Both surveys were linked to data on disability retirement awards due to MSD from national register for an 11-year follow-up...
October 24, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29059121/reliability-and-validity-of-the-floor-transfer-test-as-a-measure-of-readiness-for-independent-living-among-older-adults
#14
Gunay Ardali, Lori T Brody, Rebecca A States, Ellen M Godwin
BACKGROUND AND PURPOSE: The ability to get up from the floor after a fall is a basic skill required for functional independence. Consequently, the inability to safely get down and up from the floor or to perform a floor transfer (FT) may indicate decreased mobility and/or increased frailty. A reliable and valid test of FT ability is a critical part of the clinical decision-making process. The FT test is a simple, performance-based test that can be administered quickly and easily to determine a patient's ability to safely and successfully get down and up from the floor using any movement strategy and without time restriction...
October 20, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29054254/ecg-based-myocardial-infarction-detection-using-hybrid-firefly-algorithm
#15
Padmavathi Kora
BACKGROUND AND OBJECTIVE: Myocardial Infarction (MI) is one of the most frequent diseases, and can also cause demise, disability and monetary loss in patients who suffer from cardiovascular disorder. Diagnostic methods of this ailment by physicians are typically invasive, even though they do not fulfill the required detection accuracy. METHODS: Recent feature extraction methods, for example, Auto Regressive (AR) modelling; Magnitude Squared Coherence (MSC); Wavelet Coherence (WTC) using Physionet database, yielded a collection of huge feature set...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29051618/development-and-validation-of-a-risk-prediction-model-for-work-disability-multicohort-study
#16
Jaakko Airaksinen, Markus Jokela, Marianna Virtanen, Tuula Oksanen, Jaana Pentti, Jussi Vahtera, Markku Koskenvuo, Ichiro Kawachi, G David Batty, Mika Kivimäki
Work disability affects quality of life, earnings, and opportunities to contribute to society. Work characteristics, lifestyle and sociodemographic factors have been associated with the risk of work disability, but few multifactorial algorithms exist to identify individuals at risk of future work disability. We developed and validated a parsimonious multifactorial score for the prediction of work disability using individual-level data from 65,775 public-sector employees (development cohort) and 13,527 employed adults from a general population sample (validation cohort), both linked to records of work disability...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29048551/rapid-screening-of-risk-in-pediatric-headache-application-of-the-pediatric-pain-screening-tool
#17
Lauren C Heathcote, Jonathan Rabner, Alyssa Lebel, Jessica M Hernandez, Laura E Simons
Objective: The current study examined the application of a screening tool to identify biopsychosocial risk factors and derive prognostic risk groups in children and adolescents with headache pain. Methods: Youth (n = 242, 8-17 years, 75.6% female) presenting for evaluation at a tertiary pediatric headache clinic completed the nine-item Pediatric Pain Screening Tool (PPST) as well as measures of functional disability, pain catastrophizing, fear of pain, anxiety, and depressive symptoms...
October 10, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29045707/the-social-determinants-of-lesbian-gay-bisexual-and-transgender-youth-suicidality-in-england-a-mixed-methods-study
#18
Elizabeth McDermott, Elizabeth Hughes, Victoria Rawlings
Background: Lesbian, gay, bisexual and transgender (LGBT) youth have a higher risk of suicidality and self-harm than heterosexual youth populations but little is known about the underlying mechanisms. We aimed to investigate the social determinants of this mental health inequality. Methods: A two-stage sequential mixed method study was conducted. Firstly, 29 semi-structured interviews with LGBT youth (aged 13-25 years old) were completed. Data was analysed thematically...
October 17, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29041821/gender-matters-in-the-transition-to-employment-for-young-adults-with-physical-disabilities
#19
Sally Lindsay, Elaine Cagliostro, Mikhaela Albarico, Neda Mortaji, Dilakshan Srikanthan
PURPOSE: The purpose of this study was to explore the role of gender in the transition to employment for young adults with physical disabilities. METHODS: This study drew on in-depth interviews with a purposive sample of 33 participants (23 youth and 10 clinicians). The youth in our sample included 13 females (mean age 22.9) and 10 males (mean age 21.3) who had various types of physical disabilities. The person-environment-occupation (PEO) model informed our analysis...
October 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29035104/association-between-discrimination-and-obesity-in-african-american-men
#20
Roland J Thorpe, Lauren J Parker, Ryon J Cobb, Felicia Dillard, Janice Bowie
The objective of this study was to examine the association between discrimination and obesity among a U.S. nationally representative sample of African-American men. Data from the 2001-2003 National Survey of American Life (NSAL) were used to collect measures of everyday and major discrimination, and body mass index (BMI) taken from self-reports. Poisson regression with robust standard errors was applied to estimate the prevalence ratios of everyday and major discrimination as it relates to obesity (BMI ≥ 30 kg/m(2)), controlling for potential confounders...
2017: Biodemography and Social Biology
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