keyword
MENU ▼
Read by QxMD icon Read
search

KISS1

keyword
https://www.readbyqxmd.com/read/29902942/the-role-of-kisspeptin-neurokinin-b-dynorphin-neurons-in-pathomechanism-of-vasomotor-symptoms-in-postmenopausal-women-from-physiology-to-potential-therapeutic-applications
#1
Anna Szeliga, Adam Czyzyk, Agnieszka Podfigurna, Andrea R Genazzani, Alessandro D Genazzani, Blazej Meczekalski
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65-75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats. Hot flushes are subjective sensation of heat associated with cutaneous vasodilatation and drop in core temperature. It is suspected that VMS are strongly correlated with pulsatile oversecretion of gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH)...
June 14, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29867758/biological-significance-of-kisspeptin-kiss-1-receptor-signaling-in-the-habenula-of-teleost-species
#2
REVIEW
Satoshi Ogawa, Ishwar S Parhar
Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates. In the brain, Kiss1 gene is mainly expressed in the hypothalamic region, but KissR gene is widely distributed throughout the brain, suggesting that kisspeptin-KissR system may be involved in not only reproductive, but also non-reproductive functions. In non-mammalian vertebrates, there are two or more kisspeptin and KissR types...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29848339/rs4889-polymorphism-in-kiss1-gene-its-effect-on-polycystic-ovary-syndrome-development-and-anthropometric-and-hormonal-parameters-in-saudi-women
#3
Fadwa S Albalawi, Maha H Daghestani, Mazin H Daghestani, Abdelmoneim Eldali, Arjumand S Warsy
BACKGROUND: Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations between kisspeptin and PCOS-related reproductive hormones, and iii- investigate the relation between KISS1 gene polymorphisms and hormone levels in women suffering from PCOS. METHODS: The investigation was a clinically designed study on 28 women with PCOS, and 30 normal, healthy women with no signs of PCOS as controls...
May 30, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29843081/the-expression-of-kisspeptin-and-its-receptor-in-the-domestic-cat-ovary-and-uterus-in-different-stages-of-the-ovarian-cycle
#4
P Tanyapanyachon, O Amelkina, K Chatdarong
Kisspeptin is well known for its indispensable role in the regulation of reproduction, mainly through controlling the release of GnRH at the hypothalamic level. Recent studies have shown that kisspeptin and the kisspeptin receptor are expressed in the ovary and uterus, indicating an additional local function in reproduction at the extra-hypothalamic level. In this study, we aimed: (1) to investigate the localization pattern of kisspeptin and its receptor in the domestic cat ovary and uterus throughout the ovarian cycle using immunohistochemistry; and (2) to compare the relative expression of ovarian Kiss1 mRNA levels at different ovarian stages with qPCR analysis...
May 18, 2018: Theriogenology
https://www.readbyqxmd.com/read/29772257/conspecific-odor-exposure-predominantly-activates-non-kisspeptin-cells-in-the-medial-nucleus-of-the-amygdala
#5
Leandro Bueno Lima, Fernanda Tais Haubenthal, Marina Augusto Silveira, Tabata Mariz Bohlen, Martin Metzger, Jose Donato, Renata Frazao
A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections...
May 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29755406/the-role-of-kiss1-neurons-as-integrators-of-endocrine-metabolic-and-environmental-factors-in-the-hypothalamic-pituitary-gonadal-axis
#6
REVIEW
Shel-Hwa Yeo, William H Colledge
Kisspeptin-GPR54 signaling in the hypothalamus is required for reproduction and fertility in mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) release and modulation of the hypothalamic-pituitary-gonadal (HPG) axis. Arcuate Kiss1 neurons project to GnRH nerve terminals in the median eminence, orchestrating the pulsatile secretion of luteinizing hormone (LH) through the intricate interaction between GnRH pulse frequency and the pituitary gonadotrophs. Arcuate Kiss1 neurons, also known as KNDy neurons in rodents and ruminants because of their co-expression of neurokinin B and dynorphin represent an ideal hub to receive afferent inputs from other brain regions in response to physiological and environmental changes, which can regulate the HPG axis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29746990/hindbrain-5-monophosphate-activated-protein-kinase-mediates-short-term-food-deprivation-inhibition-of-the-gonadotropin-releasing-hormone-luteinizing-hormone-axis-role-of-nitric-oxide
#7
Manita Shakya, Prem K Shrestha, Karen P Briski
Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy sensor adenosine 5'-monophosphate-activated protein kinase (AMPK) inhibits reproductive neuroendocrine function in short-term, e.g. 18 hr food-deprived (FD) estradiol (E)-implanted ovariectomized female rats...
May 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/29721201/antitumor-efficacy-of-kisspeptin-in-human-malignant-mesothelioma-cells
#8
Vincenza Ciaramella, Carminia Maria Della Corte, Concetta Di Mauro, Stefano Tomassi, Salvatore Di Maro, Teresa Troiani, Erika Martinelli, Roberto Bianco, Sandro Cosconati, Riccardo Pierantoni, Rosaria Meccariello, Rosanna Chianese, Fortunato Ciardiello, Floriana Morgillo
Purpose: Kisspeptin signaling, via its receptors GPR54, could be an essential players in the inhibition of mesothelioma progression, invasion and metastasis formation. The loss of KiSS1 by tumor cells has been associated with a metastatic phenotype but the mechanistic insights of this process are still unknown. Experimental design: The blockade of the metastatic process at early stage is a hot topic in cancer research. We studied the role of KiSS1 on proliferation, invasiveness, migration abilities of mesothelioma cell lines focusing on the effect on epithelial-to-mesenchymal transition (EMT)...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29692674/co-expression-of-the-calcitonin-receptor-gene-in-the-hypothalamic-kisspeptin-neurons-in-female-rats
#9
Assadullah, Nahoko Ieda, Narumi Kawai, Hirotaka Ishii, Kunio Ihara, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Purpose: Hypothalamic kisspeptin neurons are considered to play a critical role in regulating mammalian reproduction and integrating humoral and neuronal inputs that control gonadotropin-releasing hormone (GnRH)/gonadotropin release. The present study aimed to investigate the upstream regulator candidates for kisspeptin neurons. Methods: Visualized kisspeptin neurons that were taken from the arcuate nucleus (ARC) of Kiss1 -tdTomato rats were subjected to next-generation sequencing (NGS) analysis...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29681889/role-of-kisspeptin-and-neurokinin-b-in-puberty-in-female-non-human-primates
#10
REVIEW
Ei Terasawa, James P Garcia, Stephanie B Seminara, Kim L Keen
In human patients, loss-of-function mutations in the genes encoding kisspeptin ( KISS1 ) and neurokinin B ( NKB) and their receptors ( KISS1R and NK3R , respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated the contribution of kisspeptin and NKB signaling to the pubertal increase in GnRH release using rhesus monkeys as a model. Direct measurements of GnRH and kisspeptin in the median eminence of the hypothalamus with infusion of agonists and antagonists for kisspeptin and NKB reveal that kisspeptin and NKB signaling stimulate GnRH release independently or collaboratively by forming kisspeptin and NKB neuronal networks depending on the developmental age...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29678280/the-kisspeptin-receptor-a-key-g-protein-coupled-receptor-in-the-control-of-the-reproductive-axis
#11
REVIEW
Delphine Franssen, Manuel Tena-Sempere
The kisspeptin receptor, Kiss1R, also known as Gpr54, is a G protein-coupled receptor (GPCR), deorphanized in 2001, when it was recognized as canonical receptor for the Kiss1-derived peptides, kisspeptins. In 2003, inactivating mutations of Kiss1R gene were first associated to lack of pubertal maturation and hypogonadotropic hypogonadism in humans and rodents. These seminal findings pointed out the previously unsuspected, essential role of Kiss1R and its ligands in control of reproductive maturation and function...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29674723/steap2-knockdown-reduces-the-invasive-potential-of-prostate-cancer-cells
#12
Stephanie E A Burnell, Samantha Spencer-Harty, Suzie Howarth, Owen Bodger, Howard Kynaston, Claire Morgan, Shareen H Doak
Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate if its knockdown resulted in reduced invasive potential of prostate cancer cells. PC3 and LNCaP cells were transfected with STEAP2 siRNA and proliferation, migration, invasion and gene expression analyses were performed...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670580/the-roles-of-kisspeptin-system-in-the-reproductive-physiology-of-fish-with-special-reference-to-chub-mackerel-studies-as-main-axis
#13
REVIEW
Hirofumi Ohga, Sethu Selvaraj, Michiya Matsuyama
Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r). Over the last 15 years, the importance of the kisspeptin system has been the subject of much debate in the mammalian research field. At the heart of the debate is whether kisspeptin is an absolute upstream regulator of gonadotropin-releasing hormone secretion, as it has been proposed to be the master molecule in reproductive events and plays a special role not only during puberty but also in adulthood...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29643834/metabolic-impact-on-the-hypothalamic-kisspeptin-kiss1r-signaling-pathway
#14
REVIEW
Fazal Wahab, Bibi Atika, Farhad Ullah, Muhammad Shahab, Rüdiger Behr
A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult. Due to its strategic location, this ligand-receptor pair acts as an integrator of cues from gonadal steroids as well as of circadian and seasonal variation-related information on the reproductive axis. Besides these cues, the activity of the hypothalamic KP signaling is very sensitive to the current metabolic status of the body...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29618281/melatonin-independent-photoperiodic-entrainment-of-the-circannual-tsh-rhythm-in-the-pars-tuberalis-of-the-european-hamster
#15
Cristina Sáenz de Miera, Dominique Sage-Ciocca, Valérie Simonneaux, Paul Pévet, Stefanie Monecke
Adaptation of biological rhythms to a seasonal environment in circannual mammals is achieved via the synchronization of intrinsic circannual rhythms to the external year by photoperiod. In mammals, the photoperiodic information is integrated to seasonal physiology via the pineal hormone melatonin regulation of pars tuberalis (PT) TSHβ expression and its downstream control of hypothalamic dio2 gene expression. In the circannual European hamster, however, photoperiodic entrainment of the circannual clock is possible in pinealectomized animals...
June 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29615476/neuronostatin-exerts-actions-on-pituitary-that-are-unique-from-its-sibling-peptide-somatostatin
#16
Raúl M Luque, Rhonda D Kineman
Neuronostatin, a somatostatin gene-encoded peptide, exerts important physiological and metabolic actions in diverse tissues. However, the direct biological effects of neuronostatin on pituitary function of humans and primates are still unknown. This study used baboon ( Papio anubis ) primary pituitary cell cultures, a species that closely models human physiology, to demonstrate that neuronostatin inhibits basal, but not ghrelin-/GnRH-stimulated, growth hormone (GH) and luteinizing hormone (LH) secretion in a dose- and time-dependent fashion, without affecting the secretion of other pituitary hormones (prolactin, ACTH, FSH, thyroid-stimulating hormone (TSH)) or changing mRNA levels...
June 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29582202/automated-quantitative-image-analysis-for-ex-vivo-metastasis-assays-reveals-differing-lung-composition-requirements-for-metastasis-suppression-by-kiss1
#17
Eric D Young, Kyle Strom, Ashley F Tsue, Joseph L Usset, Seth MacPherson, John T McGuire, Danny R Welch
Imaging is broadly used in biomedical research, but signal variation complicates automated analysis. Using the Pulmonary Metastasis Assay (PuMA) to study metastatic colonization by the metastasis suppressor KISS1, we cultured GFP-expressing melanoma cells in living mouse lung ex vivo for 3 weeks. Epifluorescence images of cells were used to measure growth, creating large datasets which were time consuming and challenging to quantify manually due to scattering of light from outside the focal plane. To address these challenges, we developed an automated workflow to standardize the measurement of disseminated cancer cell growth by applying statistical quality control to remove unanalyzable images followed and a filtering algorithm to quantify only in-focus cells...
February 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29580824/esr2-regulates-granulosa-cell-genes-essential-for-follicle-maturation-and-ovulation
#18
Vincentaben Khristi, V Praveen Chakravarthi, Prabhakar Singh, Subhra Ghosh, Archit Pramanik, Anamika Ratri, Shaon Borosha, Katherine F Roby, Michael W Wolfe, M A Karim Rumi
Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation. Ovulation failure occurred in two distinct rat models, a null mutant and a DNA binding domain (DBD) mutant of ESR2, indicating that transcriptional regulation by ESR2 is indispensable for ovulation. To define the regulatory role of ESR2 in preovulatory follicular maturation and ovulation, we investigated ovarian responsiveness to exogenous gonadotropins in prepubertal females...
March 24, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29552764/kiss1-and-kiss1r-expression-in-gastric-cancer
#19
Ioannis D Kostakis, George Agrogiannis, Aristeidis G Vaiopoulos, Eleni Mylona, Efstratios Patsouris, Gregory Kouraklis, Michael Koutsilieris
PURPOSE: Kisspeptins, which are derived from the gene KISS1, supress tumor progression. We intended to investigate the production of KISS1 and its receptor (KISSR) in gastric cancer. METHODS: The expression of KISS1 and KISS1R in both normal and cancer tissue was examined with immunohistochemistry in tissue specimens of 40 cases of gastric adenocarcinoma. RESULTS: KISS1 expression in normal gastric mucosa was much higher than in malignant mucosa...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29545200/alterations-in-placental-gene-expression-of-pregnant-women-with-chronic-chagas-disease
#20
Natalia A Juiz, Irma Torrejón, Marianela Burgos, Ana M F Torres, Tomás Duffy, Nelly M Cayo, Anahí Tabasco, Miriam Salvo, Silvia A Longhi, Alejandro G Schijman
Trypanosoma cruzi infection in women of reproductive age is associated with congenital transmission and adverse pregnancy outcomes. The placenta is a key barrier to infection. Gene expression profiles of term placental environment from T. cruzi-seropositive (SP) and -seronegative (SN) mothers were characterized by RNA-Seq. Nine pools of placental RNA paired samples were used: three from SN and six from SP tissues. Each pool consisted of female/male newborns and vaginal/cesarean delivery binomials. No newborn was congenitally infected...
June 2018: American Journal of Pathology
keyword
keyword
87280
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"