keyword
MENU ▼
Read by QxMD icon Read
search

KISS1

keyword
https://www.readbyqxmd.com/read/28615280/age-associated-gene-expression-changes-in-the-arcuate-nucleus-of-male-rhesus-macaques
#1
Dominique Eghlidi, Vasilios Garyfallou, Steven Kohama, Henryk F Urbanski
The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis, and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturation it is unclear what changes occur during aging, especially in males. Therefore, in the present study we profiled the expression of reproduction-related genes in the ARC of young and old male rhesus macaques, as well as old males that had received 6 months of hormone supplementation (HS) in the form of daily testosterone and dehydroepiandrosterone; we also compared morning versus night ARC gene expression in the old males...
June 14, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28604137/effects-of-dihydrotestosterone-administration-on-the-expression-of-reproductive-and-body-weight-regulatory-factors-in-ovariectomized-and-estradiol-treated-female-rats
#2
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Yiliyasi Mayila, Minoru Irahara
To clarify the direct effects of androgens, the changes in the hypothalamic levels of reproductive and appetite regulatory factors induced by chronic dihydrotestosterone (DHT) administration were evaluated in female rats. DHT treatment increased the BW and food intake of the ovariectomized rats, but not the estradiol (E2)-treated rats. DHT administration suppressed the expression of a hypothalamic anorexigenic factor. Although the kisspeptin (Kiss1) mRNA levels of the anterior hypothalamic block (the anteroventral periventricular nucleus, AVPV) were increased in the E2-treated rats, DHT administration did not affect the Kiss1 mRNA levels of the AVPV in the ovariectomized or E2-treated rats...
June 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28597070/the-kiss1-metastasis-suppressor-appears-to-reverse-the-warburg-effect-by-shifting-from-glycolysis-to-mitochondrial-beta-oxidation
#3
Sharon J Manley, Wen Liu, Danny R Welch
The shift by cancer cells toward aerobic glycolysis (Warburg effect) confers selective advantages by utilizing nutrients (e.g., lipids, amino acids, and nucleotides) to build biomass. Lipogenesis is generally enhanced, and its inhibition diminishes proliferation and survival. Re-expression of the metastasis suppressor KISS1 in human melanoma cells results in greater mitochondrial biogenesis, inhibition of glycolysis, utilization of beta-oxidation to provide energy, elevated oxidation of exogenous fatty acids, and increased expression of early-phase lipogenesis genes at both mRNA and protein levels...
June 8, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28583614/effects-of-active-immunization-against-gnrh-versus-surgical-castration-on-hypothalamic-pituitary-function-in-boars
#4
Xingfa Han, Yuqin Zhou, Yu Zeng, Fenfen Sui, Yacheng Liu, Yao Tan, Xiaohan Cao, Xiaogang Du, Fengyan Meng, Xianyin Zeng
The objective was to compare effects of anti-GnRH immunization (immunocastration) versus surgical castration on hypothalamic-pituitary function in boars. Thirty-six boars were randomly divided into three groups (n = 12/group): control, surgically castrated, or immunized against GnRH at 10 wk of age (boostered 8 wk later). Compared to intact boars, immunocastration reduced (P < 0.05) serum concentrations of LH, FSH, testosterone and inhibin B and caused severe testicular atrophy, whereas surgical castration increased (P < 0...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28552864/development-related-changes-in-the-expression-of-the-ovarian-kiss1-and-kiss1r-genes-and-their-sensitivity-to-hcg-in-prepubertal-female-rats
#5
Mikio Yamasaki, Akira Kuwahara, Takeshi Iwasa, Yuri Yamamoto, Yuka Taniguchi, Yuya Yano, Sumika Matsui, Toshiya Matsuzaki, Minoru Irahara
Kisspeptin, which is encoded by the Kiss1 gene, and its receptor, the G protein-coupled receptor 54 (Kiss1r), play important roles in the regulation of reproductive functions in mammals. Several studies have shown that the Kiss1 and Kiss1r genes are expressed in the rat, primate, and human ovaries, and that the ovarian kisspeptin system plays a pivotal role in ovulation at the proestrous stage in adulthood. The purpose of this study was to evaluate development-related changes in the expression of ovarian Kiss1 and Kiss1r genes and in kisspeptin levels, and to identify the regulatory factors for these genes during the prepubertal period...
May 27, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28534042/loss-of-the-habenula-intrinsic-neuromodulator-kisspeptin1-affects-learning-in-larval-zebrafish
#6
Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai, Suresh Jesuthasan
Learning how to actively avoid a predictable threat involves two steps: recognizing the cue that predicts upcoming punishment and learning a behavioral response that will lead to avoidance. In zebrafish, ventral habenula (vHb) neurons have been proposed to participate in both steps by encoding the expected aversiveness of a stimulus. vHb neurons increase their firing rate as expectation of punishment grows but reduce their activity as avoidance learning occurs. This leads to changes in the activity of raphe neurons, which are downstream of the vHb, during learning...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28522409/neonatal-exposure-to-17%C3%AE-ethynyl-estradiol-ee-disrupts-follicle-development-and-reproductive-hormone-profiles-in-female-rats
#7
Haolin Zhang, Kazuyoshi Taya, Kentaro Nagaoka, Midori Yoshida, Gen Watanabe
Toxic effects induced by exposure to endocrine-disrupting chemicals during fetal and neonatal periods can be irreversible and exert effects throughout an animal's entire life. Our previous study showed that neonatal exposure to 17α-ethynyl estradiol (EE) induced irregular estrous cycle in adults. To uncover the reason for the delayed effect after neonatal exposure to EE, reproductive parameters including ovarian weight, ovarian steroidogenesis, and hormonal profiles were investigated in developing female rats...
July 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28475285/involvement-of-neurone-glia-neurone-neurone-communications-via-gap-junctions-in-synchronised-activity-of-kndy-neurones
#8
K Ikegami, S Minabe, N Ieda, T Goto, A Sugimoto, S Nakamura, N Inoue, S Oishi, A D Maturana, M Sanbo, M Hirabayashi, K-I Maeda, H Tsukamura, Y Uenoyama
Pulsatile secretion of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone is indispensable for puberty onset and reproductive activities at adulthood in mammalian species. A cohort of neurones expressing three neuropeptides, kisspeptin, encoded by Kiss1 gene, neurokinin B (NKB) and dynorphin A, localised in the hypothalamic arcuate nucleus (ARC), so-called KNDy neurones, are a putative intrinsic source of the GnRH pulse generator. Synchronous activity among KNDy neurones is thought to be required for pulsatile GnRH secretion...
May 5, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28444173/tac1-signaling-is-required-for-sexual-maturation-and-responsiveness-of-gnrh-neurons-to-kisspeptin-in-the-male-mouse
#9
Caroline A Maguire, Yong Bhum Song, Min Wu, Silvia León, Rona S Carroll, Meenakshi Alreja, Ursula B Kaiser, Víctor M Navarro
The tachykinins substance P (SP) and neurokinin A (NKA) (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse. Here, we extended this characterization to the male mouse. Tac1-/- male mice showed delayed puberty onset. They also presented significantly decreased expression levels of Pdyn (dynorphin) and Nos1 (nitric oxide synthase) in the mediobasal hypothalamus and elevated Gnrh1 levels. Unexpectedly, the response of Tac1-/- mice to central kisspeptin or senktide (neurokinin B receptor -NK3R- agonist) administration was significantly decreased compared with controls, despite the preserved ability of GnRH neurons to stimulate LH release as demonstrated by central NMDA administration, suggesting a deficit at the GnRH neuron level...
April 21, 2017: Endocrinology
https://www.readbyqxmd.com/read/28438528/molecular-characterization-of-kiss2-receptor-and-in-vitro-effects-of-kiss2-on-reproduction-related-gene-expression-in-the-hypothalamus-of-half-smooth-tongue-sole-cynoglossus-semilaevis
#10
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Bao Shi
Kisspeptin (Kiss) and its receptor, KissR (previously known as GPR54), play a critical role in the control of reproduction and puberty onset in mammals. Additionally, a number of studies have provided evidence of the existence of multiple Kiss/KissR systems in teleosts, but the physiological relevance and functions of these kisspeptin forms (Kiss1 and Kiss2) still remain to be investigated. To this end, we examined the direct actions of Kiss2 on hypothalamic functions in the half-smooth tongue sole (Cynoglossus semilaevis), a representative species of the order Pleuronectiformes...
August 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28427900/molecular-cloning-and-characterization-of-kiss1-in-brandt-s-voles-lasiopodomys-brandtii
#11
Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
Kisspeptin, encoded by kiss1, has been regarded as a major modulator of mammalian puberty and fertility due to its stimulation on GnRH. Brandt's vole is one of the main pest species on the Inner Mongolian steppes for its striking reproductive capacity and kiss1 is a key candidate gene related to reproductive regulatory cascades. In this study, kiss1 cDNA was cloned from the hypothalamus of Brandt's voles and kiss1 mRNA levels were investigated in different tissues, and at different developmental stages, using high-throughput real-time PCR...
June 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28422142/g-protein-coupled-kiss1-receptor-is-overexpressed-in-triple-negative-breast-cancer-and-promotes-drug-resistance
#12
Alexandra Blake, Magdalena Dragan, Rommel G Tirona, Daniel B Hardy, Muriel Brackstone, Alan B Tuck, Andy V Babwah, Moshmi Bhattacharya
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy. Prognosis for this aggressive cancer subtype is poor and survival is limited due to the development of resistance to available chemotherapies and resultant metastases. The mechanisms regulating tumor resistance are poorly understood. Here we demonstrate that the G protein-coupled kisspeptin receptor (KISS1R) promotes drug resistance in TNBC cells...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416690/correction-for-padilla-et-al-agrp-to-kiss1-neuron-signaling-links-nutritional-state-and-fertility
#13
(no author information available yet)
No abstract text is available yet for this article.
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28377404/effect-of-androgen-on-kiss1-expression-and-luteinizing-hormone-release-in-female-rats
#14
Kinuyo Iwata, Yuyu Kunimura, Keisuke Matsumoto, Hitoshi Ozawa
Hyperandrogenic women have various grades of ovulatory dysfunction, which lead to infertility. The purpose of this study was to determine whether chronic exposure to androgen affects expression of kisspeptin (ovulation and follicle development regulator) or release of luteinizing hormone (LH) in female rats. Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age. Number of Kiss1-expressing cells in both the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) was significantly decreased in ovary-intact DHT rats...
April 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28370545/molecular-mechanism-of-feedback-regulation-of-17%C3%AE-estradiol-on-two-kiss-genes-in-the-protogynous-orange-spotted-grouper-epinephelus-coioides
#15
Yin Guo, Qingqing Wang, Gaofei Li, Meng He, Haipei Tang, Haifa Zhang, Xiaoli Yang, Xiaochun Liu, Haoran Lin
Kisspeptins are considered critical regulators in the hypothalamic-pituitary-gonadal axis because they can stimulate secretion of Gonadotropin-releasing hormone in mammals, and may also mediate the feedback regulation of sex steroids in the hypothalamus. Two kiss1 paralogues (kiss1 and kiss2) were identified in teleosts, hinting at their increased complexity of signaling for sex-steroid feedback regulation. In the present study, molecular pathways by which 17β-estradiol (E2 ) exerted feedback regulation on two kiss genes, via three types of estrogen receptors, were investigated in the protogynous orange-spotted grouper (Epinephelus coioides)...
March 30, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28368450/long-term-neonatal-estrogen-exposure-causes-irreversible-inhibition-of-lh-pulses-by-suppressing-arcuate-kisspeptin-expression-via-estrogen-receptors-%C3%AE-and-%C3%AE-in-female-rodents
#16
Shiori Minabe, Nahoko Ieda, Youki Watanabe, Naoko Inoue, Yoshihisa Uenoyama, Kei-Ichiro Maeda, Hiroko Tsukamura
Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, as the developing brain is highly sensitive to estrogens. Here we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes an irreversible suppression of Kiss1/kisspeptin expression in the arcuate nucleus (ARC) via the estrogen receptor alpha (ERα) and ERβ, resulting in reproductive dysfunction in female rats. Daily estradiol-benzoate (EB) administration from days 0 to 10 postpartum caused persistent vaginal diestrus in female rats...
March 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28359084/genetic-evidence-for-multifactorial-control-of-the-reproductive-axis-in-zebrafish
#17
Yun Liu, Haipei Tang, Rui Xie, Shuisheng Li, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of follicle-stimulating hormone beta (fshβ) and luteinizing hormone beta (lhβ) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that compensation mechanisms exist to stimulate the reproductive axis in the absence of kiss and gnrh...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28336267/association-analysis-of-polymorphism-in-kiss1-gene-with-reproductive-traits-in-goats
#18
Mahmoud S El-Tarabany, Asmaa W Zaglool, Akram A El-Tarabany, Ashraf Awad
Understanding the genetic information of related genes is helpful for the selection and breeding course through marker assisted selection. The aim of the current study was to detect polymorphisms of the KiSS1 gene in 137 animals, including Baladi, Zaraibi and Damascus goat breeds by PCR-RFLP, and DNA sequencing and to investigate the association between these variants and reproductive traits. Comparison of the nucleotide sequence indicated the substitution of T with A at position 121 (T121A) in the intron 1 of the KiSS1 gene in all goat breeds...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28323958/jmjd3-is-crucial-for-the-female-avpv-rip-cre-neuron-controlled-kisspeptin-estrogen-feedback-loop-and-reproductive-function
#19
Anying Song, Shujun Jiang, Qinghua Wang, Jianghuan Zou, Zhaoyu Lin, Xiang Gao
The hypothalamic-pituitary-gonadal axis controls development, reproduction, and metabolism. Although most studies have focused on the hierarchy from the brain to the gonad, many questions remain unresolved concerning the feedback from the gonad to the central nervous system, especially regarding the potential epigenetic modifications in hypothalamic neurons. In the present report, we generated genetically modified mice lacking histone H3 lysine 27 (H3K27) demethylase Jumonji domain-containing 3 (JMJD3) in hypothalamic rat-insulin-promoter-expressing neurons (RIP-Cre neurons)...
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#20
Thangal Yumnamcha, Zeeshan A Khan, Chongtham Rajiv, Sijagurumayum D Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
May 2017: Molecular Reproduction and Development
keyword
keyword
87280
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"