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https://www.readbyqxmd.com/read/28444173/tac1-signaling-is-required-for-sexual-maturation-and-responsiveness-of-gnrh-neurons-to-kisspeptin-in-the-male-mouse
#1
Caroline A Maguire, Yong Bhum Song, Min Wu, Silvia León, Rona S Carroll, Meenakshi Alreja, Ursula B Kaiser, Víctor M Navarro
The tachykinins substance P (SP) and neurokinin A (NKA) (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse. Here, we extended this characterization to the male mouse. Tac1-/- male mice showed delayed puberty onset. They also presented significantly decreased expression levels of Pdyn (dynorphin) and Nos1 (nitric oxide synthase) in the mediobasal hypothalamus and elevated Gnrh1 levels. Unexpectedly, the response of Tac1-/- mice to central kisspeptin or senktide (neurokinin B receptor -NK3R- agonist) administration was significantly decreased compared with controls, despite the preserved ability of GnRH neurons to stimulate LH release as demonstrated by central NMDA administration, suggesting a deficit at the GnRH neuron level...
April 21, 2017: Endocrinology
https://www.readbyqxmd.com/read/28438528/molecular-characterization-of-kiss2-receptor-and-in-vitro-effects-of-kiss2-on-reproduction-related-gene-expression-in-the-hypothalamus-of-half-smooth-tongue-sole-cynoglossus-semilaevis
#2
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Bao Shi
Kisspeptin (Kiss) and its receptor, KissR (previously known as GPR54), play a critical role in the control of reproduction and puberty onset in mammals. Additionally, a number of studies have provided evidence of the existence of multiple Kiss/KissR systems in teleosts, but the physiological relevance and functions of these kisspeptin forms (Kiss1 and Kiss2) still remain to be investigated. To this end, we examined the direct actions of Kiss2 on hypothalamic functions in the half-smooth tongue sole (Cynoglossus semilaevis), a representative species of the order Pleuronectiformes...
April 21, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28427900/molecular-cloning-and-characterization-of-kiss1-in-brandt-s-voles-lasiopodomys-brandtii
#3
Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
Kisspeptin, encoded by kiss1, has been regarded as a major modulator of mammalian puberty and fertility due to its stimulation on GnRH. Brandt's vole is one of the main pest species on the Inner Mongolian steppes for its striking reproductive capacity and kiss1 is a key candidate gene related to reproductive regulatory cascades. In this study, kiss1 cDNA was cloned from the hypothalamus of Brandt's voles and kiss1 mRNA levels were investigated in different tissues, and at different developmental stages, using high-throughput real-time PCR...
April 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28422142/g-protein-coupled-kiss1-receptor-is-overexpressed-in-triple-negative-breast-cancer-and-promotes-drug-resistance
#4
Alexandra Blake, Magdalena Dragan, Rommel G Tirona, Daniel B Hardy, Muriel Brackstone, Alan B Tuck, Andy V Babwah, Moshmi Bhattacharya
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy. Prognosis for this aggressive cancer subtype is poor and survival is limited due to the development of resistance to available chemotherapies and resultant metastases. The mechanisms regulating tumor resistance are poorly understood. Here we demonstrate that the G protein-coupled kisspeptin receptor (KISS1R) promotes drug resistance in TNBC cells...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416690/correction-for-padilla-et-al-agrp-to-kiss1-neuron-signaling-links-nutritional-state-and-fertility
#5
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28377404/effect-of-androgen-on-kiss1-expression-and-luteinizing-hormone-release-in-female-rats
#6
Kinuyo Iwata, Yuyu Kunimura, Keisuke Matsumoto, Hitoshi Ozawa
Hyperandrogenic women have various grades of ovulatory dysfunction, which lead to infertility. The purpose of this study was to determine whether chronic exposure to androgen affects expression of kisspeptin (ovulation and follicle development regulator) or release of luteinizing hormone (LH) in female rats. Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age. Number of Kiss1-expressing cells in both the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) was significantly decreased in ovary-intact DHT rats...
April 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28370545/molecular-mechanism-of-feedback-regulation-of-17%C3%AE-estradiol-on-two-kiss-genes-in-the-protogynous-orange-spotted-grouper-epinephelus-coioides
#7
Yin Guo, Qingqing Wang, Gaofei Li, Meng He, Haipei Tang, Haifa Zhang, Xiaoli Yang, Xiaochun Liu, Haoran Lin
Kisspeptins are considered critical regulators in the hypothalamic-pituitary-gonadal axis because they can stimulate secretion of Gonadotropin-releasing hormone in mammals, and may also mediate the feedback regulation of sex steroids in the hypothalamus. Two kiss1 paralogues (kiss1 and kiss2) were identified in teleosts, hinting at their increased complexity of signaling for sex-steroid feedback regulation. In the present study, molecular pathways by which 17β-estradiol (E2 ) exerted feedback regulation on two kiss genes, via three types of estrogen receptors, were investigated in the protogynous orange-spotted grouper (Epinephelus coioides)...
March 30, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28368450/long-term-neonatal-estrogen-exposure-causes-irreversible-inhibition-of-lh-pulses-by-suppressing-arcuate-kisspeptin-expression-via-estrogen-receptors-%C3%AE-and-%C3%AE-in-female-rodents
#8
Shiori Minabe, Nahoko Ieda, Youki Watanabe, Naoko Inoue, Yoshihisa Uenoyama, Kei-Ichiro Maeda, Hiroko Tsukamura
Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, as the developing brain is highly sensitive to estrogens. Here we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes an irreversible suppression of Kiss1/kisspeptin expression in the arcuate nucleus (ARC) via the estrogen receptor alpha (ERα) and ERβ, resulting in reproductive dysfunction in female rats. Daily estradiol-benzoate (EB) administration from days 0 to 10 postpartum caused persistent vaginal diestrus in female rats...
March 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28359084/genetic-evidence-for-multifactorial-control-of-the-reproductive-axis-in-zebrafish
#9
Yun Liu, Haipei Tang, Rui Xie, Shuisheng Li, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of follicle-stimulating hormone beta (fshβ) and luteinizing hormone beta (lhβ) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that compensation mechanisms exist to stimulate the reproductive axis in the absence of kiss and gnrh...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28336267/association-analysis-of-polymorphism-in-kiss1-gene-with-reproductive-traits-in-goats
#10
Mahmoud S El-Tarabany, Asmaa W Zaglool, Akram A El-Tarabany, Ashraf Awad
Understanding the genetic information of related genes is helpful for the selection and breeding course through marker assisted selection. The aim of the current study was to detect polymorphisms of the KiSS1 gene in 137 animals, including Baladi, Zaraibi and Damascus goat breeds by PCR-RFLP, and DNA sequencing and to investigate the association between these variants and reproductive traits. Comparison of the nucleotide sequence indicated the substitution of T with A at position 121 (T121A) in the intron 1 of the KiSS1 gene in all goat breeds...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28323958/jmjd3-is-crucial-for-female-avpv-rip-cre-neuron-controlled-kisspeptin-estrogen-feedback-loop-and-reproductive-function
#11
Anying Song, Shujun Jiang, Qinghua Wang, Jianghuan Zou, Zhaoyu Lin, Xiang Gao
The hypothalamic-pituitary-gonadal axis controls development, reproduction, and metabolism. While most studies were focusing on the hierarch from brain to gonad, many questions remain unresolved concerning the feedback from gonad to the central nervous system, especially on the potential epigenetic modification in hypothalamic neurons. In this report, we generated genetically modified mice lacking histone H3 lysine 27 demethylase JMJD3 in hypothalamic RIP-Cre neurons. The female mutant mice display late-onset obesity due to reduced locomotor activity and decreased energy expenditure...
March 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#12
Thangal Yumnamcha, Zeeshan A Khan, Chongtham Rajiv, Sijagurumayum D Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
March 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28289712/rcan1-4-is-a-thyroid-cancer-growth-and-metastasis-suppressor
#13
Chaojie Wang, Motoyasu Saji, Steven E Justiniano, Adlina Mohd Yusof, Xiaoli Zhang, Lianbo Yu, Soledad Fernández, Paul Wakely, Krista La Perle, Hiroshi Nakanishi, Neal Pohlman, Matthew D Ringel
Metastasis suppressors are key regulators of tumor growth, invasion, and metastases. Loss of metastasis suppressors has been associated with aggressive tumor behaviors and metastatic progression. We previously showed that regulator of calcineurin 1, isoform 4 (RCAN1-4) was upregulated by the KiSS1 metastatic suppression pathway and could inhibit cell motility when overexpressed in cancer cells. To test the effects of endogenous RCAN1-4 loss on thyroid cancer in vivo, we developed RCAN1-4 knockdown stable cells...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28279673/social-rank-dependent-expression-of-gonadotropin-releasing-hormones-and-kisspeptin-in-the-medaka-brain
#14
Nao Kagawa, Sayuri Hirose, Keiko Fujimoto, Chihomi Nomura, Yuuma Fujita, Akira Honda, Mai Komori
Social interactions regulate the expression of several neuropeptides that have a central role in the reproductive system of mammals. Nonmammalian vertebrates also have these neuropeptides or paralogs, however, studies on the social regulation of reproductive physiology in nonmammalian species are limited. In this study, we examined whether the expression of gonadotropin-releasing hormones (GnRHs) and kisspeptin (Kiss1) is affected by social hierarchy resulting from the outcomes of male-male competition in medaka fish (Oryzias latipes)...
March 6, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28251550/the-mystery-of-puberty-initiation-genetics-and-epigenetics-of-idiopathic-central-precocious-puberty-icpp
#15
REVIEW
Sofia Leka-Emiri, George P Chrousos, Christina Kanaka-Gantenbein
Puberty is a major developmental stage. Damaging mutations, considered as "mistakes of nature", have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic-pituitary-gonadal (HPG) axis development, in the normosmic idiopathic hypogonadotropic hypogonadism (nIHH), in the X-linked or autosomal forms of Kallmann syndrome and in precocious puberty have been identified (GNRH1, GNRHR, KISS1, GPR54, FGFR1, FGF8, PROK2, PROKR2, TAC3, TACR3, KAL1, PROK2, PROKR2, CHD7, LEP, LEPR, PC1, DAX1, SF-1, HESX-1, LHX3, PROP-1)...
March 1, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28209621/prominent-oncogenic-roles-of-evi1-in-breast-carcinoma
#16
Hui Wang, Thorsten Schaefer, Martina Konantz, Martin Braun, Zsuzsanna Varga, Anna M Paczulla, Selina Reich, Francis Jacob, Sven Perner, Holger Moch, Tanja N Fehm, Lothar Kanz, Klaus Schulze-Osthoff, Claudia Lengerke
Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens, we documented EVI1 overexpression in both estrogen receptor-positive (ER(+)) and estrogen receptor-negative (ER(-)) breast carcinomas. Here, we report prognostic relevance of EVI1 overexpression in triple-negative breast carcinoma but not in the HER2-positive breast carcinoma subset...
February 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28207895/the-metastasis-suppressor-kiss1-is-an-intrinsically-disordered-protein-slightly-more-extended-than-a-random-coil
#17
Alain Ibáñez de Opakua, Nekane Merino, Maider Villate, Tiago N Cordeiro, Georgina Ormaza, Marta Sánchez-Carbayo, Tammo Diercks, Pau Bernadó, Francisco J Blanco
The metastasis suppressor KISS1 is reported to be involved in the progression of several solid neoplasias, making it a promising molecular target for controlling their metastasis. The KISS1 sequence contains an N-terminal secretion signal and several dibasic sequences that are proposed to be the proteolytic cleavage sites. We present the first structural characterization of KISS1 by circular dichroism, multi-angle light scattering, small angle X-Ray scattering and NMR spectroscopy. An analysis of the KISS1 backbone NMR chemical shifts does not reveal any preferential conformation and deviation from a random coil ensemble...
2017: PloS One
https://www.readbyqxmd.com/read/28203796/kiss1-hexadecapeptide-directly-regulates-gonadotropin-releasing-hormone-1-in-the-scombroid-fish-chub-mackerel%C3%A2
#18
Hirofumi Ohga, Hayato Adachi, Hajime Kitano, Akihiko Yamaguchi, Michiya Matsuyama
No abstract text is available yet for this article.
February 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28196880/agrp-to-kiss1-neuron-signaling-links-nutritional-state-and-fertility
#19
Stephanie L Padilla, Jian Qiu, Casey C Nestor, Chunguang Zhang, Arik W Smith, Benjamin B Whiddon, Oline K Rønnekleiv, Martin J Kelly, Richard D Palmiter
Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating hormone) from the pituitary. This reproductive circuit is sensitive to metabolic perturbations. When challenged with starvation, insufficient energy reserves attenuate gonadotropin release, leading to infertility. The reproductive neuroendocrine circuit is well established, composed of two populations of kisspeptin-expressing neurons (located in the anteroventral periventricular hypothalamus, Kiss1(AVPV), and arcuate hypothalamus, Kiss1(ARH)), which drive the pulsatile activity of gonadotropin-releasing hormone (GnRH) neurons...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28194651/kisspeptin-10-inhibits-proliferation-and-regulates-lipolysis-and-lipogenesis-processes-in-3t3-l1-cells-and-isolated-rat-adipocytes
#20
Ewa Pruszyńska-Oszmałek, Paweł A Kołodziejski, Maciej Sassek, Joanna H Sliwowska
INTRODUCTION: Kisspeptin, which is encoded by the KISS1 gene and acts via GPR54, plays a role in the regulation of reproductive functions. Expression of KISS1 and GRPR54 has been found in peripheral tissues, including adipose tissue, and was shown to be influenced by metabolic status. PURPOSE: We hypothesized that kisspeptin could be involved in regulation of lipid metabolism in the mouse 3T3-L1 cell line and in isolated rat adipocytes. METHODS: First, we characterized expression profiles of KISS1 and GPR54 mRNA and proteins in adipose cells isolated from male rats...
February 13, 2017: Endocrine
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