keyword
MENU ▼
Read by QxMD icon Read
search

case-based scenario

keyword
https://www.readbyqxmd.com/read/28633695/how-should-discordance-between-molecular-and-growth-based-assays-for-rifampicin-resistance-be-investigated
#1
S Hofmann-Thiel, H Hoffmann, D Hillemann, L Rigouts, A Van Deun, K Kranzer
Molecular tests to detect the presence of Mycobacterium tuberculosis and genetic polymorphisms in the rpoB gene conferring resistance to rifampicin (RMP) have become integral parts of tuberculosis diagnostics worldwide. These assays are often performed sequentially or in parallel to phenotypic drug susceptibility testing. Discordances between molecular and phenotypic tests invariably occur. Root causes range from pre-, post- and analytic errors to co-existence of non-tuberculous mycobacteria, silent mutations, mutations outside the 81 base-pair RMP resistance-determining region, non-canonical mutations conferring increased minimal inhibitory concentrations below the critical concentration in some phenotypic drug susceptibility tests, and heteroresistance...
July 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28628811/evaluating-pedestrian-behavior-at-crosswalks-validation-of-a-pedestrian-behavior-questionnaire-for-the-u-s-population
#2
Shuchisnigdha Deb, Lesley Strawderman, Janice DuBien, Brian Smith, Daniel W Carruth, Teena M Garrison
The aim of this study was to develop and validate a self-reporting Pedestrian Behavior Questionnaire (PBQ) for the U.S. population to measure frequency of risky behaviors among pedestrians. The PBQ includes 50 survey items that allow respondents to rate the frequency with which they engage in different types of road-using behaviors as pedestrians. The validation study was conducted on 425 participants (228 males and 197 females) between the ages of 18 and 71. Confirmatory factor analysis differentiated pedestrian behaviors into five factor categories: violations, errors, lapses, aggressive behaviors, and positive behaviors...
June 16, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28628732/understanding-neurophobia-reasons-behind-impaired-understanding-and-learning-of-neuroanatomy-in-cross-disciplinary-healthcare-students
#3
Muhammad Asim Javaid, Shelly Chakraborty, John F Cryan, Harriët Schellekens, André Toulouse
Recent studies have highlighted a fear or difficulty with the study and understanding of neuroanatomy among medical and healthcare students. This has been linked with a diminished confidence of clinical practitioners and students to manage patients with neurological conditions. The underlying reasons for this difficulty have been queried among a broad cohort of medical, dental, occupational therapy, and speech and language sciences students. Direct evidence of the students' perception regarding specific difficulties associated with learning neuroanatomy has been provided and some of the measures required to address these issues have been identified...
June 19, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28628677/impact-of-a-31-gene-expression-profiling-test-for-cutaneous-melanoma-on-dermatologists-clinical-management-decisions
#4
Aaron S Farberg, Alex M Glazer, Richard White, Darrell S Rigel
<p>Importance: Current guidelines for cutaneous malignant melanoma (CMM) provide general recommendations regarding surveillance while indicating that management should be tailored to patients' individual probability of recurrence. A 31-gene expression profile (31-GEP) test to predict metastatic risk has been previously validated, and classifies patients as either Class 1 (low risk) or Class 2 (high risk).</p> <p>Objective: To determine the impact of the 31-GEP test's result on clinical decision-making...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28625339/non-invasive-ventilation-in-emergency-departments-in-public-hospitals-in-catalonia-the-venur-cat-study
#5
J Jacob, J Zorrilla, E Gené, G Alonso, P Rimbau, F Casarramona, C Netto, P Sánchez, R Hernández, X Escalada, Ò Miró
OBJECTIVES: To know the implementation and characteristics of non-invasive ventilation (NIV) in the Emergency Departments (EDs) of public hospitals in Catalonia (Spain) and analyze possible differences based on the typology, degree of activity and the availability of an Intensive Care Unit (ICU) in the hospital. DESIGN: A non-interventional, descriptive study was carried out, using a structured questionnaire divided into 3sections: 1) professional experience and training; 2) devices used; and 3) clinical scenarios and the use of NIV...
June 15, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28621945/concentration-driven-selectivity-of-energy-transfer-channels-and-color-tunability-in-ba3la-po4-3-tb-3-sm-3-for-warm-white-leds
#6
Weijie Zhou, Meng Gu, Yiyi Ou, Caihua Zhang, Xuejie Zhang, Lei Zhou, Hongbin Liang
Here, we report the large-scale emission color tunability in Ba3La(PO4)3:Tb(3+), Sm(3+) (BLPO:TS) system based on the detailed discussion on the concentration-driven selectivity of energy transfer (ET) channels from Tb(3+) to Sm(3+). It is induced by the concentration-dependent (5)D3 and (5)D4 emissions of Tb(3+) and the different interaction mechanisms of ET from Tb(3+) to Sm(3+) via (5)D3 and (5)D4 channels. In the diluted Tb(3+) scenario, the red emission of Sm(3+) is efficiently sensitized via the (5)D3 channel, while in the concentrated Tb(3+) case, the contribution of (5)D4 channel is dominant...
June 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28621586/the-cooler-code-a-novel-analytical-approach-to-calculate-subcellular-energy-deposition-by-internal-electron-emitters
#7
Mattia Siragusa, Giorgio Baiocco, Pil M Fredericia, Werner Friedland, Torsten Groesser, Andrea Ottolenghi, Mikael Jensen
COmputation of Local Electron Release (COOLER), a software program designed for dosimetry assessment at the cellular/subcellular scale, with a given distribution of administered low-energy electron-emitting radionuclides in cellular compartments, which remains a critical step in risk/benefit analysis for advancements in internal radiotherapy. The software is intended to overcome the main limitations of the medical internal radiation dose (MIRD) formalism for calculations of cellular S-values (i.e., dose to a target region in the cell per decay in a given source region), namely, the use of the continuous slowing down approximation (CSDA) and the assumption of a spherical cell geometry...
June 16, 2017: Radiation Research
https://www.readbyqxmd.com/read/28620848/cost-effectiveness-of-pembrolizumab-vs-standard-of-care-chemotherapy-as-first-line-treatment-for-metastatic-nsclc-that-expresses-high-levels-of-pd-l1-in-the-united-states
#8
Min Huang, Yanyan Lou, James Pellissier, Thomas Burke, Frank Xiaoqing Liu, Ruifeng Xu, Vamsidhar Velcheti
OBJECTIVES: Our objectives were to evaluate the cost effectiveness of pembrolizumab compared with standard-of-care (SoC) platinum-based chemotherapy as first-line treatment in patients with metastatic non-small-cell lung cancer (NSCLC) that expresses high levels of programmed death ligand-1 (PD-L1) [tumour proportion score (TPS) ≥50%], from a US third-party public healthcare payer perspective. METHODS: We conducted a partitioned-survival model with a cycle length of 1 week and a base-case time horizon of 20 years...
June 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28618843/risk-of-cardiac-death-among-cancer-survivors-in-the-united-states-a-seer-database-analysis
#9
Omar Abdel-Rahman
 Background: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28618661/probabilistic-quantitative-microbial-risk-assessment-model-of-norovirus-from-wastewater-irrigated-vegetables-in-ghana-using-genome-copies-and-fecal-indicator-ratio-conversion-for-estimating-exposure-dose
#10
Emmanuel de-Graft Johnson Owusu-Ansah, Angelina Sampson, Samuel K Amponsah, Robert C Abaidoo, Anders Dalsgaard, Tine Hald
The need to replace the commonly applied fecal indicator conversions ratio (an assumption of 1:10(-5) virus to fecal indicator organism) in Quantitative Microbial Risk Assessment (QMRA) with models based on quantitative data on the virus of interest has gained prominence due to the different physical and environmental factors that might influence the reliability of using indicator organisms in microbial risk assessment. The challenges facing analytical studies on virus enumeration (genome copies or particles) have contributed to the already existing lack of data in QMRA modelling...
June 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28616816/access-to-community-care-for-people-with-dementia-and-their-informal-carers-case-vignettes-for-a-european-comparison-of-structures-and-common-pathways-to-formal-care
#11
A Bieber, A Stephan, H Verbeek, F Verhey, L Kerpershoek, C Wolfs, M de Vugt, R T Woods, J Røsvik, G Selbaek, B M Sjölund, A Wimo, L Hopper, K Irving, M J Marques, M Gonçalves-Pereira, E Portolani, O Zanetti, G Meyer
BACKGROUND: People with dementia and their informal carers often do not receive appropriate professional support or it is not received at the right time. OBJECTIVES: Description and comparison of common pathways to formal community dementia care in eight European countries as a part of the transnational Actifcare project. MATERIALS AND METHODS: The German team was responsible for creating an individual case scenario as a starting point. The research teams in Ireland, Italy, the Netherlands, Norway, Portugal, Sweden, and the United Kingdom were then asked to describe a common pathway to formal dementia care by writing their own vignette using the provided individual case scenario...
June 14, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28609192/evaluation-of-the-well-mixed-room-and-near-field-far-field-models-in-occupational-settings
#12
Susan F Arnold, Yuan Shao, Gurumurthy Ramachandran
Drawing appropriate conclusions about a scenario for which the exposure is truly unacceptable drives appropriate exposure and risk management, and protects the health and safety of those individuals. To ensure the vast majority of these decisions are accurate, these decisions must be based upon proven approaches and tools. When these decisions are based solely on professional judgment guided by subjective inputs however, they are more than likely wrong, and biased, underestimating the true exposure. Models have been shown anecdotally to be useful in accurately predicting exposure but their use in occupational hygiene has been limited...
June 13, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28606869/predicting-mental-conditions-based-on-history-of-present-illness-in-psychiatric-notes-with-deep-neural-networks
#13
Tung Tran, Ramakanth Kavuluru
BACKGROUND: Applications of natural language processing to mental health notes are not common given the sensitive nature of the associated narratives. The CEGS N-GRID 2016 Shared Task in Clinical Natural Language Processing (NLP) changed this scenario by providing the first set of neuropsychiatric notes to participants. This study summarizes our efforts and results in proposing a novel data use case for this dataset as part of the third track in this shared task. OBJECTIVE: We explore the feasibility and effectiveness of predicting a set of common mental conditions a patient has based on the short textual description of patient's history of present illness typically occurring in the beginning of a psychiatric initial evaluation note...
June 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28606755/recommendations-of-the-spanish-working-group-on-crohn-s-disease-and-ulcerative-colitis-geteccu-on-the-monitoring-prevention-and-treatment-of-post-operative-recurrence-in-crohn-s-disease
#14
Eugeni Domènech, Antonio López-Sanromán, Pilar Nos, Maribel Vera, María Chaparro, María Esteve, Javier P Gisbert, Míriam Mañosa
Despite the availability of new, powerful drugs for Crohn's disease, a significant proportion of patients will undergo an intestinal resection to control the disease as it develops. In the absence of an effective preventative treatment, the appearance of new intestinal lesions after surgery for Crohn's disease is the norm; this is known as post-operative recurrence and may appear very early on, even a few weeks after the surgical resection. Furthermore, the drugs that are currently available for the prevention of post-operative recurrence have a limited effect; up to 50% of cases present recurrent Crohn's disease activity despite the preventative treatment, which may require further surgery with the consequent loss of intestinal function, leading some patients to suffer from short bowel syndrome as an irreversible complication...
June 9, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28606362/cost-of-porcine-reproductive-and-respiratory-syndrome-virus-at-individual-farm-level-an-economic-disease-model
#15
H Nathues, P Alarcon, J Rushton, R Jolie, K Fiebig, M Jimenez, V Geurts, C Nathues
Porcine reproductive and respiratory syndrome (PRRS) is reported to be among the diseases with the highest economic impact in modern pig production worldwide. Yet, the economic impact of the disease at farm level is not well understood as, especially in endemically infected pig herds, losses are often not obvious. It is therefore difficult for farmers and veterinarians to appraise whether control measures such as virus elimination or vaccination will be economically beneficial for their farm. Thus, aim of this study was to develop an epidemiological and economic model to determine the costs of PRRS for an individual pig farm...
July 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28606148/development-of-a-stochastic-agent-based-model-to-evaluate-surveillance-strategies-for-detection-of-emergent-porcine-reproductive-and-respiratory-syndrome-strains
#16
A G Arruda, Z Poljak, D Knowles, A McLean
BACKGROUND: The objective of the current study was to develop a stochastic agent-based model using empirical data from Ontario (Canada) swine sites in order to evaluate different surveillance strategies for detection of emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains at the regional level. Four strategies were evaluated, including (i) random sampling of fixed numbers of swine sites monthly; (ii) risk-based sampling of fixed numbers, specifically of breeding sites (high-consequence sites); (iii) risk-based sampling of fixed numbers of low biosecurity sites (high-risk); and (iv) risk-based sampling of breeding sites that are characterized as low biosecurity sites (high-risk/high-consequence)...
June 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28602000/integrated-waste-load-allocation-for-river-water-pollution-control-under-uncertainty-a-case-study-of-tuojiang-river-china
#17
Jiuping Xu, Shuhua Hou, Liming Yao, Chaozhi Li
This paper presents a bi-level optimization waste load allocation programming model under a fuzzy random environment to assist integrated river pollution control. Taking account of the leader-follower decision-making in the water function zones framework, the proposed approach examines the decision making feedback relationships and conflict coordination between the river basin authority and the regional Environmental Protection Agency (EPA) based on the Stackelberg-Nash equilibrium strategy. In the pollution control system, the river basin authority, as the leader, allocates equitable emissions rights to different subareas, and the then subarea EPA, as the followers, reallocates the limited resources to various functional zones to minimize pollution costs...
June 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28600218/systematic-review-of-patient-specific-surgical-simulation-toward-advancing-medical-education-%C3%A2
#18
Won Hyung A Ryu, Navjit Dharampal, Ahmed E Mostafa, Ehud Sharlin, Gail Kopp, William Bradley Jacobs, Robin John Hurlbert, Sonny Chan, Garnette R Sutherland
OBJECTIVE: Simulation-based education has been shown to be an effective tool to teach foundational technical skills in various surgical specialties. However, most of the current simulations are limited to generic scenarios and do not allow continuation of the learning curve beyond basic technical skills to prepare for more advanced expertise, such as patient-specific surgical planning. The objective of this study was to evaluate the current medical literature with respect to the utilization and educational value of patient-specific simulations for surgical training...
June 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28599818/dealing-with-uncertainty-when-using-a-surveillance-system
#19
Gaëtan Texier, Liliane Pellegrin, Claire Vignal, Jean-Baptiste Meynard, Xavier Deparis, Hervé Chaudet
INTRODUCTION: Epidemiologists manage outbreak identification and confirmation by means of a "situation diagnosis", which involves validating (or invalidating) an alarm (signal identified as abnormal) as an alert (a real, characterized outbreak) and proposing the first countermeasures. This work investigates how uncertainty is materialized during this stage, and how experts develop strategies to address this uncertainty with the help of an early warning system. METHODS: We built an experiment using a simulation platform with a scenario involving both a natural and an intentional outbreak...
August 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28598948/causes-for-pauses-during-simulated-pediatric-cardiac-arrest
#20
David Oren Kessler, Dawn Taylor Peterson, Alexis Bragg, Yiqun Lin, John Zhong, Jonathan Duff, Mark Adler, Linda Brown, Farhan Bhanji, Jennifer Davidson, David Grant, Adam Cheng
OBJECTIVES: Pauses in cardiopulmonary resuscitation negatively impact clinical outcomes; however, little is known about the contributing factors. The objective of this study is to determine the frequency, duration, and causes for pauses during cardiac arrest. DESIGN: This is a secondary analysis of video data collected from a prospective multicenter trial. Twenty-six simulated pediatric cardiac arrest scenarios each lasting 12 minutes in duration were analyzed by two independent reviewers to document events surrounding each pause in chest compressions...
June 8, 2017: Pediatric Critical Care Medicine
keyword
keyword
8728
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"