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Laryngopharyngeal reflux

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https://www.readbyqxmd.com/read/29218658/hypopharyngeal-multichannel-intraluminal-impedance-leads-to-the-promising-outcome-of-antireflux-surgery-in-japanese-population-with-laryngopharyngeal-reflux-symptoms
#1
Takeshi Suzuki, Yosuke Seki, Yoshitaka Okamoto, Toshitaka Hoppo
BACKGROUND: Clinical characteristics of laryngopharyngeal reflux (LPR) in Japanese population remain unclear, and its treatment outcome is suboptimal. The objectives of this study were to evaluate Japanese patients with LPR symptoms using hypopharyngeal multichannel intraluminal impedance (HMII) and to assess the outcome of antireflux surgery (ARS). METHODS: Subjects included patients who had LPR symptoms for > 12 weeks or laryngoscopic findings suggestive of LPR and underwent laryngoscopy and esophageal testing including HMII...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29200375/a-case-of-laryngeal-granuloma-likely-caused-by-laryngopharyngeal-reflux-disease-following-a-sagittal-split-ramus-osteotomy
#2
Mami Nakamura, Akio Uda, Naokazu Kataoka, Kana Nagasaka, Kazuhisa Tamashige, Daichi Mori, Hideo Niwa, Koh Shibutani
Laryngeal granuloma is an uncommon complication of prolonged endotracheal intubation. A 25-year-old woman with severe jaw deformity underwent sagittal split ramus osteotomy under general anesthesia. Two days after extubation, the patient complained of hoarseness, sore throat, and dyspnea. When symptoms persisted, she was evaluated in the Otolaryngology Department. She was diagnosed with laryngeal granuloma of the bilateral arytenoid cartilages, and conservative treatment was selected. Administration of corticosteroid hormones, proton pump inhibitors, and a subsequent follow-up examination performed in our outpatient clinic showed no evidence of recurrence 10 months after the initial presentation...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29174850/association-between-pepsin-in-the-saliva-and-the-subjective-symptoms-in-patients-with-laryngopharyngeal-reflux
#3
Ah Ra Jung, Oh Eun Kwon, Jung Min Park, Sung Hwa Dong, Su Young Jung, Young Chan Lee, Young-Gyu Eun
OBJECTIVES: Our study was designed to further evaluate the relationships between the saliva pepsin level and the symptoms and quality of life of patients with laryngopharyngeal reflux (LPR). STUDY DESIGN: A prospective cohort study without controls. SETTING: Tertiary teaching hospital. SUBJECTS AND METHODS: We analyzed 50 patients diagnosed with LPR by 24-hour multichannel intraluminal impedance pH monitoring. All subjects were instructed to collect saliva samples upon waking in the morning...
November 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29168025/relationship-between-the-severity-of-laryngopharyngeal-reflux-and-sleep-apnea-using-drug-induced-sleep-endoscopy-dise
#4
Joong Seob Lee, Sung Jae Heo, Jung Soo Kim, Dongbin Ahn, Jin Ho Sohn, Heejin Kim
OBJECTIVES: The aim of the study is to identify the following associations: (1) severity of obstructive sleep apnea syndrome (OSAS) and laryngopharyngeal reflux (LPR)-related clinical parameters, such as reflux finding score (RFS), reflux symptom index (RSI), and LPR-health-related quality of life (LPR-HRQOL) and (2) complete obstruction on drug-induced sleep endoscopy (DISE) and LPR-related clinical parameters. MATERIALS AND METHODS: Subjects included the OSAS patients without surgery history and all patients perform the polysomnography (PSG) and DISE for their OSAS...
November 22, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29152746/referral-patterns-from-emergency-department-to-otolaryngology-clinic
#5
Jonathan C Garneau, Isaac Wasserman, Neeraja Konuthula, Benjamin D Malkin
OBJECTIVES/HYPOTHESIS: Patients who present to the emergency department (ED) with various otolaryngologic disorders are frequently referred to an otolaryngologist for follow-up care. Our aim was to further characterize this group as it has not been well described in the literature. STUDY DESIGN: Cross-sectional retrospective study. METHODS: We reviewed the charts of patients seen during an 18-month period in an urban public hospital trauma center adult ED and referred to an otolaryngology clinic for follow-up care...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29110918/in-response-to-the-commentary-of-dr-lou-on-treatment-of-laryngopharyngeal-reflux-using-a-sleep-positioning-device-a-prospective-cohort-study
#6
William S Tierney, Scott L Gabbard, Paul C Bryson
No abstract text is available yet for this article.
October 3, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29100672/treating-laryngopharyngeal-reflux-evaluation-of-an-anti-reflux-program-with-comparison-to-medications
#7
Jin Yang, Salem Dehom, Stephanie Sanders, Thomas Murry, Priya Krishna, Brianna K Crawley
OBJECTIVE: To determine if an anti-reflux induction program relieves laryngopharyngeal reflux (LPR) symptoms more effectively than medication and behavioral changes alone. STUDY DESIGN: Retrospective study. SETTING: Tertiary care academic center. SUBJECTS AND METHODS: A database was populated with patients treated for LPR. Patients were included in the study group if they completed a two-week anti-reflux program (diet, alkaline water, medications, behavioral modifications)...
October 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29099730/benign-vocal-fold-lesions-update-on-nomenclature-cause-diagnosis-and-treatment
#8
Matthew R Naunheim, Thomas L Carroll
PURPOSE OF REVIEW: The management of benign vocal fold lesions (BVFLs) continues to evolve. This article will review the recent literature surrounding the nomenclature, cause, diagnosis, and treatment of BVFLs, including polyps, nodules, cysts, and reactive lesions. RECENT FINDINGS: The taxonomy of vocal fold lesions has been refined, and it serves as a common descriptive language for diagnosis, treatment algorithms, and reporting of outcomes. Though these lesions are known to be the result of phonotrauma, investigation into inflammatory mediators, apoptosis, and laryngopharyngeal reflux provide further elucidation of their underlying pathophysiology...
December 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29098155/quantifying-laryngopharyngeal-reflux-in-singers-perceptual-and-objective-findings
#9
Adam T Lloyd, Bari Hoffman Ruddy, Erin Silverman, Vicki M Lewis, Jeffrey J Lehman
This study examines the relationship between laryngopharyngeal reflux (LPR) symptoms and oropharyngeal pH levels in singers. We hypothesized that reported symptoms would correlate with objective measures of pH levels from the oropharynx, including the number and total duration of reflux episodes. Twenty professional/semiprofessional singers completed the Reflux Symptom Index (RSI) and underwent oropharyngeal pH monitoring. Mild, moderate, or severe pH exposure was recorded during oropharyngeal pH monitoring...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29094873/chronic-cough-evaluation-and-management
#10
REVIEW
Charlie Michaudet, John Malaty
Although chronic cough in adults (cough lasting longer than eight weeks) can be caused by many etiologies, four conditions account for most cases: upper airway cough syndrome, gastroesophageal reflux disease/laryngopharyngeal reflux disease, asthma, and nonasthmatic eosinophilic bronchitis. Patients should be evaluated clinically (with spirometry, if indicated), and empiric treatment should be initiated. Other potential causes include angiotensin-converting enzyme inhibitor use, environmental triggers, tobacco use, chronic obstructive pulmonary disease, and obstructive sleep apnea...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29072674/comparison-of-impedance-and-pepsin-detection-in-the-laryngeal-mucosa-to-determine-impedance-values-that-indicate-pathological-laryngopharyngeal-reflux
#11
Martin Formánek, Debora Jančatová, Pavel Komínek, Radoslava Tomanová, Karol Zeleník
OBJECTIVE: Recently, a 24-h impedance was used to detect laryngopharyngeal reflux (LPR). However, not every case of LPR is pathological. Thus, pathological pharyngeal impedance values need to be clearly established to diagnose pathological LPR. The aim of our study was to establish pathological 24-h pharyngoesophageal impedance/pH values for the diagnosis of LPR. METHODS: The study was conducted in a tertiary care setting. A total of 30 patients who were referred to microlaryngoscopy for a laryngeal pathology that might be caused by LPR were included in this prospective study...
October 26, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29061118/high-resolution-manometry-in-patients-with-and-without-globus-pharyngeus-and-or-symptoms-of-laryngopharyngeal-reflux
#12
Heyan Ding, Zhijun Duan, Dong Yang, Zhifeng Zhang, Lixia Wang, Xiaoyu Sun, Yiwen Yao, Xue Lin, Hang Yang, Shan Wang, Jiande D Z Chen
BACKGROUND: Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpose of this study was to clarify the related risk factors of these patients with a final objective of improving the curative effect. METHODS: Forty two patients afflicted with globus pharyngeus (G group) and 38 patients without globus pharyngeus (NG group) were included in this study...
October 23, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29044536/effect-of-matrix-metalloproteinase-inhibitor-on-disrupted-e-cadherin-after-acid-exposure-in-the-human-nasal-epithelium
#13
Byoungjae Kim, Hyun-Ji Lee, Nu-Ri Im, Doh Young Lee, Cha Young Kang, Il-Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung-Kuk Baek, Tae Hoon Kim
OBJECTIVE: Laryngopharyngeal reflux disease (LPRD) is one of potential factors in recalcitrant chronic rhinosinusitis with or without polyps. An increase in junctional permeability in the nasal mucosa in LPRD may be due to disrupted protein bridge formation with cell-to-cell adhesion molecules such as E-cadherin. Despite the relationship between nasal mucosal inflammation and LPRD, the clear mechanism by which acid reflux affects the nasal epithelium remains unclear. METHODS: The expression levels and distribution patterns of E-cadherin in primary culture of nasal epithelial cells after acid exposure with or without dexamethasone and matrix metalloproteinase (MMP) inhibitor were determined using Western blot and immunocytochemistry...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29024410/eight-weeks-of-omeprazole-20-mg-significantly-reduces-both-laryngopharyngeal-reflux-and-comorbid-chronic-rhinosinusitis-signs-and-symptoms-randomised-double-blind-placebo-controlled-trial
#14
S A Anzić, M Turkalj, A Župan, M Labor, D Plavec, T Baudoin
OBJECTIVES: Gastroesophageal reflux recommended treatment (dose and duration) with proton-pump inhibitor (PPI) compared to placebo significantly reduces the signs and symptoms of laryngopharyngeal reflux (LPR) and comorbid chronic rhinosinusitis (CRS). DESIGN: Double-blind randomised placebo-controlled trial. SETTING: Eight weeks of treatment with omeprazole 20 mg once daily (OD). PARTICIPANTS: Sixty patients (28 women, aged 19-87 years) with diagnosed LPR and comorbid CRS...
October 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28993603/comparison-of-characteristics-according-to-reflux-type-in-patients-with-laryngopharyngeal-reflux
#15
Jun Seok Lee, Ah Ra Jung, Jung Min Park, Myung Jin Park, Young Chan Lee, Young-Gyu Eun
Objectives: To analyze laryngopharyngeal reflux (LPR) as an acidic, nonacidic, or mixed type according to 24-hour multichannel intraluminal impedance (MII) pH monitoring and the clinical characteristics of each type. Methods: Ninety patients were prospectively enrolled in this study. All patients underwent 24-hour MII pH monitoring as a diagnostic tool. Eighty-three patients were diagnosed with LPR. The patients were classified into three groups according to the pH of the hypopharyngeal probe: the acid reflux group, nonacid reflux group, and mixed reflux group...
October 10, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28974837/laryngopharyngeal-reflux-disease-lprd
#16
Nizama Salihefendic, Muharem Zildzic, Emir Cabric
INTRODUCTION: Laryngopharyngeal reflux disease (LPRD) referes to an inflammatory reaction of the mucous membrane of pharynx, larynx and other associated respiratory organs, caused by a reflux of stomach contents into the esophagus. LPRD is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated through different fields of medicine, often without a proper diagnosis. In gastroenterology it is still considered to be a manifestation of GERD, which stands for gastroesophageal reflux disease...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28929074/role-of-laryngopharyngeal-reflux-in-complications-of-tonsillectomy-in-pediatric-patients
#17
Ziya Salturk, Tolgar Lutfi Kumral, Ahmet Arslanoglu, Imran Aydogdu, Guven Yildirim, Guler Berkiten, Yavuz Uyar
Tonsillectomy and tonsillectomy with adenoidectomy are among the most common surgical procedures in otolaryngology practice. Gastroesophageal reflux was identified as a risk factor for complications in tonsillectomy. This prospective study was designed to assess the role of reflux in the development of complications following tonsillectomy in pediatric patients. Children (n = 60) who underwent tonsillectomy with adenoidectomy were divided into two groups, i.e., the laryngopharyngeal reflux (LPR) group and control group...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28884487/radiofrequency-ablation-in-patients-with-large-cervical-heterotopic-gastric-mucosa-and-globus-sensation-closing-the-treatment-gap
#18
Ivan Kristo, Erwin Rieder, Matthias Paireder, Katrin Schwameis, Gerd Jomrich, Werner Dolak, Thomas Parzefall, Martin Riegler, Reza Asari, Sebastian F Schoppmann
OBJECTIVES: Symptomatic cervical heterotopic gastric mucosa also addressed as cervical inlet patch (CIP) may present in varying shapes and causes symptoms of laryngopharyngeal reflux (LPR) like globus sensations, hoarseness and chronic cough. Unfortunately, argon plasma coagulation, standard treatment of small symptomatic CIP, is limited in large CIP mainly due to concerns of stricture formation. Therefore, we aimed to investigate radiofrequency ablation (RFA), a novel minimal-invasive ablation method, in the treatment of CIP focusing on large symptomatic patches...
September 7, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28880991/a-comparison-of-alkaline-water-and-mediterranean-diet-vs-proton-pump-inhibition-for-treatment-of-laryngopharyngeal-reflux
#19
COMPARATIVE STUDY
Craig H Zalvan, Shirley Hu, Barbara Greenberg, Jan Geliebter
Importance: Laryngopharyngeal reflux (LPR) is a common disorder with protean manifestations in the head and neck. In this retrospective study, we report the efficacy of a wholly dietary approach using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with that of the traditional treatment approach of proton pump inhibition (PPI) and standard reflux precautions. Objective: To determine whether treatment with a diet-based approach with standard reflux precautions alone can improve symptoms of LPR compared with treatment with PPI and standard reflux precautions...
October 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28880985/dietary-modifications-in-the-treatment-of-laryngopharyngeal-reflux-will-an-apple-a-day-keep-the-laryngopharyngeal-reflux-away
#20
Robert T Kavitt
No abstract text is available yet for this article.
October 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
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