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Laryngopharyngeal reflux

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https://www.readbyqxmd.com/read/29436212/correlation-between-the-reflux-finding-score-and-the-reflux-symptom-index-in-patients-with-laryngopharyngeal-reflux
#1
M Gelardi, M Silvestri, G Ciprandi
LaryngoPharyngeal Reflux (LPR) is characterized by symptoms, signs, and/or tissue damage resulting from the aggression of the gastrointestinal contents in the upper airways. The Reflux Finding Score (RFS) assesses the laryngeal signs through laryngoscopy. The Reflux Symptom Index (RSI) scores the LPR symptoms. The objective of this real-world study was to compare RFS with RSI in a cohort of Italian LPR patients. Globally, 3932 patients with LPR were evaluated and RFS and RSI were assessed in all subjects. A moderate correlation was found between RSI and RFS (r=0...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436210/relieving-laryngopharingeral-reflux-relief-survey-in-otolaryngology-the-viewpoint-of-the-otorhinolaryngologist
#2
M Gelardi, M Silvestri, G Ciprandi
Laryngopharyngeal Reflux (LPR) should be considered as part of extraesophageal reflux (EER). This reflux involves respiratory structures other than, or in addition to, the oesophagus. A new medical device for the treatment of gastric reflux, including LPR, has been launched in Italy: Marial®. Therefore, the aim of the present survey was to analyse the prescriptive behaviour both considering the past or current treatments and clinical features during a specialist routine visit. The current survey was conducted in 86 Otorhinolaryngological centers, distributed in all of Italy...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#3
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29399800/double-blind-placebo-controlled-study-with-alginate-suspension-for-laryngopharyngeal-reflux-disease
#4
Wen-Hsuan Tseng, Ping-Huei Tseng, Jia-Feng Wu, Ya-Chin Hsu, Ting-Yi Lee, Yen-Hsuan Ni, Hsiu-Po Wang, Tzu-Yu Hsiao, Wei-Chung Hsu
OBJECTIVE: Treatment for laryngopharyngeal reflux disease (LPRD) is challenging because of delays in recognition and poor responsiveness to proton-pump inhibitor therapy. The aim of this study was to determine the efficacy and safety of liquid alginate suspension for treating LPRD. METHODS: A double-blind, placebo-controlled, prospective study comparing 8 weeks of treatment with Alginos Oral Suspension (TTY Biopharm Co. Ltd., Taipei, Taiwan) (sodium alginate 1,000 mg three times daily) with a placebo was conducted on patients who fulfilled the criteria of at least one symptom consistent with LPRD, a total reflux symptom index (RSI) score of > 10, and a total reflux finding score (RFS) of > 5...
February 5, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29336901/image-analysis-of-the-interarytenoid-area-to-detect-laryngopharyngeal-reflux-disease
#5
Jerome R Lechien, Bernard Harmegnies, Sven Saussez
No abstract text is available yet for this article.
January 4, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29336899/commentary-on-letter-to-the-editor-on-manuscript-image-analysis-of-interarytenoid-area-to-detect-cases-of-laryngopharyngeal-reflux-an-objective-method
#6
Anindya Nayak
No abstract text is available yet for this article.
January 4, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29327685/the-role-of-pepsin-in-the-laryngopharyngeal-reflux
#7
Katarzyna Kowalik, Antoni Krzeski
Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is categorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases separately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition, changes in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the reflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the functions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29277812/association-between-laryngopharyngeal-reflux-and-radiation-induced-mucositis-in-head-and-neck-cancer
#8
Kohtaro Eguchi, Masami Suzuki, Shota Ida, Keita Mori, Hisao Imai, Shigehiro Kudo, Ken Ando, Keiko Higuchi, Takeshi Ebara
BACKGROUND/AIM: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis. PATIENTS AND METHODS: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Based on endoscopic findings, baseline laryngeal signs were evaluated using the reflux finding score (RFS), and the severity of mucositis was assessed during and after radiation therapy...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29262444/-ryan-index-for-detection-of-laryngopharyngeal-reflux-diseases
#9
W Wu, G Wang, L Wang, H D Liu, Q Wang, X H Xu, R Y Ding, B X Xu, H L Han, Y Zhou, J Gong, H N Wang, B W Li, Z Z Sun
Objective: To explore the utility of pharyngeal pH monitoring which positive standard is Ryan index in diagnosis of laryngopharyngeal reflux disease. Methods: In a retrospective study, clinical data of 590 patients who had symptoms laryngopharyngeal reflux disease from February 2016 to March 2017 were analyzed. All patients were received electronic laryngoscopy, assessment of reflux symptom index(RSI) and reflux finding score(RFS), and pharyngeal pH monitoring. SPSS 19.0 software was used to analyze the date...
December 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29246392/image-analysis-of-interarytenoid-area-to-detect-cases-of-laryngopharyngeal-reflux-an-objective-method
#10
Anindya Nayak, Sunil Kumar, Rubeena Arora, Gautam Bir Singh
PURPOSE: To diagnose Laryngopharyngeal Reflux by observing colour (Red, Green, Blue) at the interarytenoid area during 70° laryngeal endoscopy. MATERIALS AND METHODS: Endoscopic images from 50 normal controls and 50 patients of LPR were obtained in this observational study. LPR patients were selected on the basis of RSI and RFS. Images were analysed using ImageJ, a free image analysis software, developed by the National Institute of Health (NIH). Colour changes in the form of RGB (red, green, blue) values were calculated and analysed at the interarytenoid area...
November 28, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29238875/pepsin-in-saliva-as-a-diagnostic-biomarker-in-laryngopharyngeal-reflux-a-meta-analysis
#11
REVIEW
Jing Wang, Yu Zhao, Jianjun Ren, Yang Xu
OBJECTIVE: Pepsin in saliva has been proposed as a biomarker for the diagnosis of laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. We used Stata 12.0 to summarize the diagnostic indexes for the meta-analysis...
December 13, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29218658/hypopharyngeal-multichannel-intraluminal-impedance-leads-to-the-promising-outcome-of-antireflux-surgery-in-japanese-population-with-laryngopharyngeal-reflux-symptoms
#12
Takeshi Suzuki, Yosuke Seki, Yoshitaka Okamoto, Toshitaka Hoppo
BACKGROUND: Clinical characteristics of laryngopharyngeal reflux (LPR) in Japanese population remain unclear, and its treatment outcome is suboptimal. The objectives of this study were to evaluate Japanese patients with LPR symptoms using hypopharyngeal multichannel intraluminal impedance (HMII) and to assess the outcome of antireflux surgery (ARS). METHODS: Subjects included patients who had LPR symptoms for > 12 weeks or laryngoscopic findings suggestive of LPR and underwent laryngoscopy and esophageal testing including HMII...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29200375/a-case-of-laryngeal-granuloma-likely-caused-by-laryngopharyngeal-reflux-disease-following-a-sagittal-split-ramus-osteotomy
#13
Mami Nakamura, Akio Uda, Naokazu Kataoka, Kana Nagasaka, Kazuhisa Tamashige, Daichi Mori, Hideo Niwa, Koh Shibutani
Laryngeal granuloma is an uncommon complication of prolonged endotracheal intubation. A 25-year-old woman with severe jaw deformity underwent sagittal split ramus osteotomy under general anesthesia. Two days after extubation, the patient complained of hoarseness, sore throat, and dyspnea. When symptoms persisted, she was evaluated in the Otolaryngology Department. She was diagnosed with laryngeal granuloma of the bilateral arytenoid cartilages, and conservative treatment was selected. Administration of corticosteroid hormones, proton pump inhibitors, and a subsequent follow-up examination performed in our outpatient clinic showed no evidence of recurrence 10 months after the initial presentation...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29174850/association-between-pepsin-in-the-saliva-and-the-subjective-symptoms-in-patients-with-laryngopharyngeal-reflux
#14
Ah Ra Jung, Oh Eun Kwon, Jung Min Park, Sung Hwa Dong, Su Young Jung, Young Chan Lee, Young-Gyu Eun
OBJECTIVES: Our study was designed to further evaluate the relationships between the saliva pepsin level and the symptoms and quality of life of patients with laryngopharyngeal reflux (LPR). STUDY DESIGN: A prospective cohort study without controls. SETTING: Tertiary teaching hospital. SUBJECTS AND METHODS: We analyzed 50 patients diagnosed with LPR by 24-hour multichannel intraluminal impedance pH monitoring. All subjects were instructed to collect saliva samples upon waking in the morning...
November 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29168025/relationship-between-the-severity-of-laryngopharyngeal-reflux-and-sleep-apnea-using-drug-induced-sleep-endoscopy-dise
#15
Joong Seob Lee, Sung Jae Heo, Jung Soo Kim, Dongbin Ahn, Jin Ho Sohn, Heejin Kim
OBJECTIVES: The aim of the study is to identify the following associations: (1) severity of obstructive sleep apnea syndrome (OSAS) and laryngopharyngeal reflux (LPR)-related clinical parameters, such as reflux finding score (RFS), reflux symptom index (RSI), and LPR-health-related quality of life (LPR-HRQOL) and (2) complete obstruction on drug-induced sleep endoscopy (DISE) and LPR-related clinical parameters. MATERIALS AND METHODS: Subjects included the OSAS patients without surgery history and all patients perform the polysomnography (PSG) and DISE for their OSAS...
January 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29152746/referral-patterns-from-emergency-department-to-otolaryngology-clinic
#16
Jonathan C Garneau, Isaac Wasserman, Neeraja Konuthula, Benjamin D Malkin
OBJECTIVES/HYPOTHESIS: Patients who present to the emergency department (ED) with various otolaryngologic disorders are frequently referred to an otolaryngologist for follow-up care. Our aim was to further characterize this group as it has not been well described in the literature. STUDY DESIGN: Cross-sectional retrospective study. METHODS: We reviewed the charts of patients seen during an 18-month period in an urban public hospital trauma center adult ED and referred to an otolaryngology clinic for follow-up care...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29110918/in-response-to-the-commentary-of-dr-lou-on-treatment-of-laryngopharyngeal-reflux-using-a-sleep-positioning-device-a-prospective-cohort-study
#17
William S Tierney, Scott L Gabbard, Paul C Bryson
No abstract text is available yet for this article.
October 3, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29100672/treating-laryngopharyngeal-reflux-evaluation-of-an-anti-reflux-program-with-comparison-to-medications
#18
Jin Yang, Salem Dehom, Stephanie Sanders, Thomas Murry, Priya Krishna, Brianna K Crawley
OBJECTIVE: To determine if an anti-reflux induction program relieves laryngopharyngeal reflux (LPR) symptoms more effectively than medication and behavioral changes alone. STUDY DESIGN: Retrospective study. SETTING: Tertiary care academic center. SUBJECTS AND METHODS: A database was populated with patients treated for LPR. Patients were included in the study group if they completed a two-week anti-reflux program (diet, alkaline water, medications, behavioral modifications)...
January 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29099730/benign-vocal-fold-lesions-update-on-nomenclature-cause-diagnosis-and-treatment
#19
Matthew R Naunheim, Thomas L Carroll
PURPOSE OF REVIEW: The management of benign vocal fold lesions (BVFLs) continues to evolve. This article will review the recent literature surrounding the nomenclature, cause, diagnosis, and treatment of BVFLs, including polyps, nodules, cysts, and reactive lesions. RECENT FINDINGS: The taxonomy of vocal fold lesions has been refined, and it serves as a common descriptive language for diagnosis, treatment algorithms, and reporting of outcomes. Though these lesions are known to be the result of phonotrauma, investigation into inflammatory mediators, apoptosis, and laryngopharyngeal reflux provide further elucidation of their underlying pathophysiology...
December 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29098155/quantifying-laryngopharyngeal-reflux-in-singers-perceptual-and-objective-findings
#20
Adam T Lloyd, Bari Hoffman Ruddy, Erin Silverman, Vicki M Lewis, Jeffrey J Lehman
This study examines the relationship between laryngopharyngeal reflux (LPR) symptoms and oropharyngeal pH levels in singers. We hypothesized that reported symptoms would correlate with objective measures of pH levels from the oropharynx, including the number and total duration of reflux episodes. Twenty professional/semiprofessional singers completed the Reflux Symptom Index (RSI) and underwent oropharyngeal pH monitoring. Mild, moderate, or severe pH exposure was recorded during oropharyngeal pH monitoring...
2017: BioMed Research International
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