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Laryngopharyngeal reflux

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https://www.readbyqxmd.com/read/27825368/impact-of-laryngopharyngeal-reflux-on-subjective-and-objective-voice-assessments-a-prospective-study
#1
Jérôme R Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies, Sven Saussez
BACKGROUND: Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. METHODS: Forty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months...
November 8, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27803078/the-role-of-helicobacter-pylori-in-laryngopharyngeal-reflux-a-systematic-review-and-meta-analysis
#2
REVIEW
Ross Campbell, Shaun J Kilty, Brian Hutton, James P Bonaparte
OBJECTIVE: The primary objective was to determine the prevalence of Helicobacter pylori among patients with laryngopharyngeal reflux. The secondary objective was determining if H pylori eradication leads to greater symptom improvement in patients with laryngopharyngeal reflux as compared with standard proton pump inhibitor therapy alone. DATA SOURCES: EMBASE, Cumulative Index to Nursing and Allied Health Literature, MEDLINE, World Health Organization International Clinical Trials Registry Platform, European Union Clinical Trials Register, Cochrane Library databases of clinical trials, and ClinicalTrials...
November 1, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27780384/predicting-feeding-tube-and-tracheotomy-dependence-in-laryngeal-cancer-patients
#3
John Patrick Lavo, David Ludlow, Matt Morgan, Gloria Caldito, Cherie-Ann Nathan
CONCLUSIONS: The two scales reliably measure laryngeal edema and dysfunction in laryngeal cancer patients. The eight categories from these scales, and abnormal pharyngeal squeeze, can be used to form a new rating scale intended to help clinicians identify and circumvent swallowing complications after chemo-irradiation. OBJECTIVES: The objectives were to compare two laryngeal edema rating scales in laryngeal cancer patients and determine if post-radiation +/- chemotherapy edema predicts dependence on a feeding tube and/or tracheostomy...
October 26, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27777056/validity-and-reliability-of-the-filipino-reflux-symptom-index
#4
José Florencio F Lapeña, Giancarla Marie C Ambrocio, Ryner Jose D Carrillo
OBJECTIVES: This study aimed to establish validity and reliability of the Filipino Reflux Symptom Index (FRSI) and to test it among patients with laryngopharyngeal reflux (LPR) before and after 6 months' trial of rabeprazole. STUDY DESIGN: A case-control study was carried out. METHODS: There were 35 LPR patients and 30 controls who were twice-administered the FRSI and Filipino Voice Handicap Index (FVHI) for test-retest reliability, and videostroboscopy was performed to obtain baseline reflux finding scores (RFSs)...
October 21, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27759910/laryngopharyngeal-reflux-and-herpes-simplex-virus-type-2-are-possible-risk-factors-for-adult-onset-recurrent-respiratory-papillomatosis-prospective-case-control-study
#5
M Formánek, D Jančatová, P Komínek, P Matoušek, K Zeleník
OBJECTIVE: The human papillomavirus (HPV) causes recurrent respiratory papillomatosis (RRP). Although HPV prevalence is high, the incidence of papillomatosis is low. Thus, factors other than HPV infection probably contribute to RRP. This study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (ChT) and whether laryngopharyngeal reflux (LPR) occurs in this group of patients more often. DESIGN: Prospective case-control study...
October 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27727676/gastrooesophageal-reflux-and-laryngopharyngeal-reflux-and-its-association-with-bronchial-asthma
#6
Pankaj Kumar Singh
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727523/the-importance-of-combined-24-hour-multichannel-intraluminal-impedance-ph-monitoring-in-the-evaluation-of-children-with-suspected-laryngopharyngeal-reflux
#7
I Pavić, I Babić, J Čepin Bogović, I Hojsak
OBJECTIVE: The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected laryngopharyngeal reflux (LPR). DESIGN, SETTING AND PARTICIPANTS: A prospective study including children in whom, due to LPR suggestive symptoms, MII-pH monitoring was performed at tertiary medical centre from February 2012 to July 2015. INTERVENTIONS: All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24-hour MII-pH monitoring...
October 11, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27666704/-preliminary-application-of-dx-ph-monitoring-system-in-laryngopharyngeal-reflux-disease
#8
H L Han, J H Zhao, Y L Zhang, M Wang, H F Wang, J N Cheng, Y Feng, K Q Luo, Q P Lyu
Objective: To summarize the application and significance of Dx-pH monitoring system in laryngopharyngeal reflux disease. Methods: Fifty-four patients who had symptoms of laryngopharyngeal reflux disease in our department from February to December in 2015 were retrospectively analyzed in this study. All patients were evaluated with reflux symptoms index(RSI), flexible laryngoscope and reflux finding score(RFS), and larygopharygeal Dx-pH monitoring. Results: Among all 54 patients, there were 26 patients whose Ryan score were positive(48...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27666703/-a-comparison-of-ph-4-and-ph-5-as-thresholds-for-24-hour-ph-monitoring-in-the-diagnosis-of-laryngopharyngeal-reflux
#9
J S Wang, J R Li
Objective: To evaluate the consistency between 24-hour pH monitoring, reflux symptom index(RSI) and reflux finding score(RFS) when using pH<4 or pH<5 as threshold for 24-hour pH monitoring in the diagnosis of laryngopharyngeal reflux. Methods: Patients who presented with suspicious laryngopharyngeal reflux between February 2014 and December 2015 were included in this study. pH<4 and pH<5 reflux episodes, RSI and RFS were collected. The consistency between 24-hour pH monitoring and scale results were analyzed when pH<4 or pH<5 as threshold respectively...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27647519/a-mixed-methods-study-of-patient-views-on-reflux-symptoms-and-medication-routines
#10
Jessica M Pisegna, Sky Yang, Audrey Purcell, Alix Rubio
OBJECTIVES: Gastroesophageal reflux disease is a chronic disorder often accompanied by laryngopharyngeal reflux. Speech-language pathologists are tasked with treating these patients with voice, dysphagia, and/or reflux therapy. This study investigated patient-reported reasons for reduced compliance with recommended reflux treatment and the top symptoms in patients with reflux, dysphagia, and voice symptoms. STUDY DESIGN: This study used a cross-sectional qualitative and quantitative mixed-methods design to identify and describe patients' reflux symptoms and reflux medication routines...
September 16, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27644563/efficacy-of-proton-pump-inhibitor-in-combination-with-rikkunshito-in-patients-complaining-of-globus-pharyngeus
#11
Sei-Ichi Nakano, Hidetaka Iwasaki, Eiji Kondo, Katsushi Miyazaki, Haruhiko Shizuku, Sei-Ichiro Kamimura, Junya Fukuda, Ryo Kanamura, Noriaki Takeda
OBJECTIVE: Globus pharyngeus (GP) is a common symptom of laryngopharyngeal reflux disease (LPRD), and proton pump inhibitor (PPI) and rikkunshito, a traditional Japanese medicine having prokinetic effect improve LPRD symptoms. In the present study, we examined the efficacy of high-dose PPI in combination with rikkunshito in patients complaining of GP. METHODS: 106 patients complaining of GP without any organic endoscopic findings were enrolled. RESULTS: Patients were first administrated with high-dose PPI alone for 4 to 8 weeks and the symptom was improved in 65 patients...
2016: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/27625129/-the-expression-and-significance-of-pepsin-in-laryngeal-carcinoma
#12
J J Tan, L Wang, Z F Huang, Y F Li, W D Tian, X Liu, F F Zeng, X P Li
OBJECTIVE: To evaluate the relationship between pepsin induced by laryngopharyngeal reflux and laryngeal carcinoma. METHODS: Patients with vocal cord leukoplakia(n=18) and laryngeal carcinoma(n=21) encountered in Nanfang Hospital between December 2012 and April 2014 were included and sixteen healthy volunteers were recruited as control. Laryngeal biopsy specimens were taken from the patients with laryngeal carcinoma, or vocal cord leukoplakia and control subjects for the immunohistochemical study of pepsin...
August 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27554511/patient-reported-outcome-measures-related-to-laryngopharyngeal-reflux-a-systematic-review-of-instrument-development-and-validation
#13
REVIEW
David O Francis, Dhyanesh A Patel, Rohit Sharda, Kristen Hovis, Nila Sathe, David F Penson, Irene D Feurer, Melissa L McPheeters, Michael F Vaezi
OBJECTIVES: Patient-reported outcome (PRO) measures are often used to diagnose laryngopharyngeal reflux (LPR) and monitor treatment outcomes in clinical and research settings. The present systematic review was designed to identify currently available LPR-related PRO measures and to evaluate each measure's instrument development, validation, and applicability. DATA SOURCES: MEDLINE via PubMed interface, CINAHL, and Health and Psychosocial Instrument databases were searched with relevant vocabulary and key terms related to PRO measures and LPR...
December 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27554506/dual-ph-with-multichannel-intraluminal-impedance-testing-in-the-evaluation-of-subjective-laryngopharyngeal-reflux-symptoms
#14
Evan C Cumpston, Joel H Blumin, Jonathan M Bock
OBJECTIVES: Minimal data exist to define the use of contemporary dual pH with multichannel intraluminal impedance (MII) probes integrating both pharyngeal acid and impedance sensors to evaluate laryngopharyngeal reflux (LPR) symptoms in a laryngology clinic population. This study was performed to review a series of patients tested with dual pH-MII for suspected LPR symptoms and to analyze pH-MII data findings for this patient cohort. STUDY DESIGN: Case series with planned data collection...
December 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27536364/pharyngeal-ph-monitoring-in-gastrectomy-patients-what-do-we-really-measure
#15
Dirk Wilhelm, Alissa Jell, Hubertus Feussner, Roland M Schmid, Monther Bajbouj, Valentin Becker
AIM: Diagnosis of laryngopharyngeal reflux (LPR) has dramatically increased over the last years. For diagnosis of gastroesophageal reflux, a newly designed pharyngeal probe (Dx-pH) was recently introduced. It is also recommended to guide therapy decision in antireflux surgery. However, diagnostic results are questionable. Therefore, we establish a reliable reference group with asymptomatic patients after total gastrectomy and, thus, complete extinction of gastric acid production. METHODS: Pharyngeal pH monitoring was performed in 10 consecutive patients with history of total gastrectomy...
August 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27499436/new-inflammatory-parameters-in-laryngopharyngeal-reflux
#16
H Arslan, T Çandar, S Kuran, Ş H Akmansu, S Kocatürk
OBJECTIVES: To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment. METHODS: Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment. RESULTS: The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37...
September 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27497049/validation-of-the-laryngopharyngeal-reflux-color-and-texture-recognition-compared-to-ph-probe-monitoring
#17
Chen Du, Jehad Al-Ramahi, Qingsong Liu, Yan Yan, Jack Jiang
OBJECTIVE/HYPOTHESIS: The objective of this study was to determine the validity of our laryngopharyngeal reflux (LPR) diagnostic system from our previous study (Witt et al.) against the results of a standard pH probe monitoring. We hypothesized that subjects with abnormal pH probe results demonstrate color and texture abnormalities that would be classified as LPR according to artificial neural network (ANN) analysis. STUDY DESIGN: Retrospective analysis. METHODS: Eighty-two subjects, including 18 pH-positive, 11 pH-negative, and 53 control subjects were tested for LPR through multichannel intraluminal impedance 24-hour pH (MII-24pH) monitoring...
August 6, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27495070/the-suitability-of-the-gerdyzer-instrument-in-ph-test-proven-laryngopharyngeal-reflux-patients
#18
Cheng-Pin Wu, Wen-Miin Liang, Chen-Chi Wang, Chi-Sen Chang, Hong-Zen Yeh, Jeng-Yuan Hsu, Chung-Wang Ko, Shou-Wu Lee, Shu-Chuan Chang, Fung-Chang Sung, Han-Chung Lien
The use of validated patient-reported outcome (PRO) instruments for the treatment outcome measure of laryngopharyngeal reflux (LPR) is crucial given the lack of objective markers. However, current symptom-based PRO instruments can only partially capture the impact of LPR. The GERD Analyzer (GERDyzer), an existing disease-specific PRO instrument, which measures multidimensional health-related quality of life (HRQL) affected by the illness rather than by any specific symptoms, has been validated in patients with erosive gastroesophageal reflux disease (GERD)...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27472044/an-assessment-of-olfactory-function-in-patients-with-laryngopharyngeal-reflux-disease
#19
Mehmet Emre Dinc, Abdullah Dalgic, Mehmet Ozgur Avincsal, Seckin Ulusoy, Akgun Celik, Omer Necati Develioglu
CONCLUSIONS: The results reported here indicate that there was a statistically significant difference in the olfactory functions of laryngopharyngeal reflux patients vs the healthy group. To the best of the authors' knowledge, this study is the first to evaluate the olfactory function of patients diagnosed with laryngopharyngeal reflux using an objective method, 24-h pH monitoring. OBJECTIVES/HYPOTHESIS: The aim of this study was to investigate olfactory functions in laryngopharyngeal reflux (LPR) patients and compare the results with healthy controls...
July 29, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27455157/diagnosis-and-treatment-of-the-extraesophageal-manifestations-of-gastroesophageal-reflux-disease
#20
Feroze Sidhwa, Alessandra Moore, Elaine Alligood, Piero Marco Fisichella
OBJECTIVE: To review the clinical presentation, diagnosis, and treatment options available for management of extraesophageal manifestations of gastroesophageal reflux disease (GERD) and to compare the most recent technological advances to the existing guidelines. SUMMARY BACKGROUND DATA: Extraesophageal manifestations of GERD include cough, laryngopharyngeal reflux (LPR), and asthma. Recent advances in diagnostic modalities may have outpaced the existing diagnostic and therapeutic clinical guidelines...
August 5, 2016: Annals of Surgery
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