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Laryngopharyngeal reflux

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https://www.readbyqxmd.com/read/28822426/-laryngopharyngeal-reflux-disease-and-laryngeal-precancerous-lesions
#1
Z W Li, S H Zhou
The laryngopharyngeal reflux disease (LPRD) is a general term for a series of symptoms and signs caused by reflux of the stomach contents to the upper part of the esophageal sphincter. In recent years, the laryngopharyngeal reflux (LPR) is getting more and more attention as laryngeal precancerous lesions and risk factors of laryngeal cancer. Laryngeal precancerous lesions plays a important role in the development of laryngeal cancer process. This article will review the role and mechanisms of LPR in the laryngeal precancerous lesions, and the status of anti-reflux in the treatment of laryngeal precancerous lesions...
August 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28822425/-understanding-of-laryngopharyngeal-reflux-is-in-confusion
#2
G Chen, W J Liao, X W Zhang
No abstract text is available yet for this article.
August 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28815026/the-diagnostic-value-of-24-hour-ambulatory-intraesophageal-ph-impedance-in-patients-with-laryngopharyngeal-reflux-symptoms-comparable-with-typical-symptoms
#3
Yusuf S Sakin, Rukiye Vardar, Baha Sezgin, Zeynep Erdogan Cetin, Yasemin Alev, Esra Yildirim, Tayfun Kirazli, Serhat Bor
BACKGROUND: The diagnosis of laryngopharyngeal reflux is currently based on a combination of the patient history of multichannel intraluminal impedance and ambulatory pH (MII-pH); however, none of these findings alone is specific for the diagnosis of laryngopharyngeal reflux. We aimed to compare the baseline characteristics and esophageal baseline impedance values between patients with and without laryngopharyngeal reflux symptoms. METHODS: We retrospectively analyzed data from two groups of patients with laryngopharyngeal reflux according to their reflux finding score (RFS) as scored by ENTs...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28796094/patulous-eustachian-tube-dysfunction-patient-demographics-and-comorbidities
#4
Bryan K Ward, Yehia Ashry, Dennis S Poe
OBJECTIVE: The objective is to describe a large cohort of patients presenting with patulous Eustachian tube (pET) dysfunction. STUDY DESIGN: Retrospective patient series. SETTING: Tertiary referral center. PATIENTS: All outpatient visits (2004-2016) that were assigned ICD9 code (381.7-Patulous Eustachian tube) were screened. Only patients with observed tympanic membrane movements during ipsilateral nasal breathing or acoustic reflex decay testing demonstrating transmitted nasal breathing were included (n = 190, n = 239 ears)...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28768359/-laryngopharyngeal-reflux-disease-lprd-in-children
#5
Oliver Reichel, Panagiotis Saravakos, Kai J Lorenz
LPRD in children is characterized by symptoms, clinical findings, and sequelae caused by the reflux of gastric acid, bile acid or refluxate containing pepsin beyond the esophagus. For diagnostic procedures and therapy of gastroesophageal reflux disease (GERD) in children and adults widely accepted guidelines have been established. However, diagnosis and therapy of LPRD in children remains a continuous issue of inter- and intradisciplinary discussions. Although both GERD and LPRD in children are reflux-induced diseases, these two entities are different in symptoms, cause, diagnostic procedures, and therapy...
July 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28760537/randomized-double-blind-trial-of-amitriptyline-versus-placebo-in-treatment-of-chronic-laryngopharyngeal-neuropathy
#6
Minyoung Jang, Samuel J Rubin, Daniel J Stein, Jacob Pieter Noordzij
OBJECTIVE: A neuropathic etiology has been suggested for patients with chronic laryngopharyngitis symptoms without visible structural pathology. Prior studies have shown that treatment with neuro-modulating medications is beneficial, but it is unknown if this was due to placebo effect. Our objective was to compare the efficacy of amitriptyline versus placebo in treating chronic laryngopharyngeal neuropathy. STUDY DESIGN: Prospective, randomized placebo-controlled trial...
July 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28756936/detecting-laryngopharyngeal-reflux-by-immunohistochemistry-of-pepsin-in-the-biopsies-of-vocal-fold-leukoplakia
#7
Xia Gong, Xiao-Yun Wang, Li Yang, Ming-Jun Sun, Jun Du, Wei Zhang
Laryngopharyngeal reflux (LPR) may contribute to the development of laryngeal diseases including vocal fold leukoplakia. Clinical methods of determining LPR are limited. Pepsin, as an exogenous protein, is considered as a biomarker of LPR. The aim of the current study was, therefore, to detect pepsin by immunohistochemistry in the biopsies from patients with vocal fold leukoplakia, and by which, to determine the potential association of LPR and vocal leukoplakia. A total of 26 biopsies from patients with vocal fold leukoplakia were examined in comparison with 20 vocal fold biopsies from control subjects...
July 27, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28731842/role-of-pepsin-and-oropharyngeal-ph-monitoring-to-assess-the-postoperative-outcome-of-patients-with-laryngopharyngeal-reflux-results-of-a-pilot-trial
#8
Michael Weitzendorfer, Richard Pfandner, Stavros A Antoniou, Werner Langsteger, Kai Witzel, Klaus Emmanuel, Oliver O Koch
BACKGROUND: The aim of this study was to evaluate the value of salivary pepsin and oropharyngeal pH-monitoring to assess the surgical outcome of patients with laryngopharyngeal reflux (LPR). MATERIALS AND METHODS: Twenty consecutive patients with LPR despite proton pump inhibitor treatment received laparoscopic antireflux surgery. Twenty-four hour esophageal pH-monitoring (multichannel intraluminal impedance monitoring [MII]-pH) and esophageal manometry (high-resolution manometry) data were documented preoperatively and at 3-month follow-up...
July 21, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28730666/weaning-of-proton-pump-inhibitors-in-patients-with-suspected-laryngopharyngeal-reflux-disease
#9
R Jun Lin, Shaum Sridharan, Libby J Smith, VyVy N Young, Clark A Rosen
OBJECTIVE: To evaluate the feasibility of a proton pump inhibitor (PPI) weaning protocol in a cohort of patients following successful empiric treatment for suspected laryngopharyngeal reflux disease (LPRD). STUDY DESIGN: Retrospective chart review. METHODS: LPRD patients were weaned from PPIs using a standardized weaning protocol. Symptom recurrence rate following PPI wean and present PPI use were determined. All numeric data were analyzed...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28728242/-expression-and-significance-of-pepsin-in-lingual-tonsil-hypertrophy
#10
Y Q Deng, L Wang, H H Chen, J J Tan, C K Gao, X X Huang, X Y Han, X P Li
Objective: To discuss the relationship between lingual tonsil hypertrophy and laryngopharyngeal reflux. Methods: Ninety-two patients who received throat surgery in Nanfang Hospital between October 2015 and October 2016 were enrolled. Twenty-six healthy volunteers were recruited as normal controls. All participants were assessed with the reflux finding score(RFS) and the size of lingual tonsils were evaluated using a clinical grading system proposed by Friedman under electronic laryngoscope. The score of reflux symptom index(RSI), personal history and medical history were gathered...
July 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28717979/impact-of-age-on-laryngopharyngeal-reflux-disease-presentation-a-multi-center-prospective-study
#11
Jérôme R Lechien, Camille Finck, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies, Sven Saussez
The objective is to assess the differences in the severity of symptoms, signs, voice quality, and quality of life before and after treatment according to age in suspected laryngopharyngeal reflux (LPR) patients. The design used in this paper is prospective multi-center study. Eighty clinically diagnosed LPR patients with a reflux finding score (RFS) >7 and a reflux symptom index (RSI) >13 were treated with pantoprazole and diet recommendations for 3 months. Patients were subdivided into three groups according their age: group 1 (18-39 years, N = 21), group 2 (40-59 years, N = 31), and group 3 (≥60 years, N = 28)...
July 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28688630/treatment-of-laryngopharyngeal-reflux-using-a-sleep-positioning-device-a-prospective-cohort-study
#12
William S Tierney, Scott L Gabbard, Claudio F Milstein, Michael S Benninger, Paul C Bryson
OBJECTIVE: Laryngopharyngeal reflux (LPR) symptoms are often resistant to management and cause significant quality of life impairment to patients with this disease. This study assesses the utility of a sleep-positioning device (SPD) in treating LPR. DESIGN: Single center prospective cohort study. SETTING: Tertiary medical center PARTICIPANTS: 27 adult patients with diagnosed laryngopharyngeal reflux. INTERVENTION: An SPD consisting of a two-component wedge-shaped base pillow and a lateral positioning body pillow (Medcline, Amenity Health Inc...
June 27, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28658344/substernal-goiter-and-laryngopharyngeal-reflux
#13
Mariana Gonçalves Rodrigues, Vergilius José Furtado de Araujo, Leandro Luongo de Matos, Flávio Carneiro Hojaij, Cesar Augusto Simões, Vergilius José Furtado de Araujo, Daniel Marin Ramos, Renata Lorencetti Mahmoud, Letícia de Moraes Mosca, Gustavo Borges Manta, Erivelto Martinho Volpi Lenine Garcia Brandão, Claudio Roberto Cernea
Objective: This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. Subjects and methods: A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014...
June 26, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28655420/comparison-of-the-effects-of-esomeprazole-plus-mosapride-citrate-and-botulinum-toxin-a-on-vocal-process-granuloma
#14
Lei Lei, Hui Yang, Xinsheng Zhang, Jia Ren
OBJECTIVES: Vocal process granulomas have a high tendency for persistence despite many treatment alternatives. Anti-reflux medications or botulinum toxin A injections are the main current therapies. There are no studies that compare the effects on vocal process granuloma of proton pump inhibitors plus prokinetic agents with botulinum toxin A injections. STUDY DESIGN: Prospective cohort study. METHODS: Adult patients reporting to our outpatient department complaining of trachyphonia and/or abnormal pharyngeal sensations who were found to have contact granulomas...
June 21, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28636735/salivary-epidermal-growth-factor-concentrations-in-patients-with-sj%C3%A3-gren-syndrome-and-laryngopharyngeal-reflux
#15
Claudia A Eckley, Marco Antônio Dos Anjos Corvo, Luis Roberto Sardinha, Bianca Liquidato, Luiz Vicente Rizzo
Sjögren syndrome was chosen as a clinical model to study acinar salivary deficiencies in the development of laryngopharyngeal reflux (LPR). The objective of this prospective cohort study was to compare salivary epidermal growth factor (EGF) concentrations of patients with Sjögren syndrome with and without LPR and gastroesophageal reflux disease (GERD) with normal controls. LPR was diagnosed with positive scores on the Reflux Symptom Index and Reflux and Reflux Finding Score, corroborated by esophagogastroduodenoscopy and/or 24-hour pH-metry...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28626103/-study-on-lifestyle-in-patients-with-gastroesophageal-%C3%A2-reflux-disease
#16
Lingzhi Yuan, Dan Tang, Jin Peng, Nanfang Qu, Chun Yue, Fen Wang
To investigate the correlation between certain unhealthy lifestyles and the incidence of gastroesophageal reflux disease (GERD), thus to provide the lifestyle guidelines for GERD patients.
 Methods: Retrospective study were conducted for 402 GERD and 276 non-GERD out-patients in Department of Gastroenterology, Third Xiangya Hospital, Central South University from August, 2014 to August, 2015 based on questionnaire survey, then the correlation of unhealthy lifestyles with GERD were analyzed.
 Results: The top 10 common symptoms for GERD were as follows: reflux, acid regurgitation, postprandial fullness, heartburn, swallow obstruction or pain, epigastric burning sensation, paraesthesia pharynges, poststernal pain, chronic laryngopharyngitis, and chronic cough...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28620964/does-gene-expression-in-laryngeal-subsites-differ-between-patients-with-laryngopharyngeal-reflux-and-controls
#17
J M Wood, D J Hussey, C M Woods, D Astill, D I Watson, B Lee, A S Carney
OBJECTIVE: To identify laryngeal mRNA gene changes in patients with laryngopharyngeal reflux (LPR). METHOD: Laryngeal biopsies from non-smoking LPR patients (n=10; Reflux Symptom Index (RSI) >12 and a Reflux Finding Score (RFS) >6) and controls (n=9; RSI <12 and RFS <6) were collected from four subsites (true vocal cord, false vocal cord, medial arytenoid and posterior commissure) of the larynx. qRT-PCR analyses were conducted on 20 reflux- and inflammation-related genes, including interleukins 6 and 8, cytokeratins 8 and 14, mucin genes MUC1, MUC2, MUC3B, MUC4, MUC5B, MUC6 and MUC7 and carbonic anhydrase III...
June 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28606786/the-utility-of-the-reflux-symptom-index-for-diagnosis-of-laryngopharyngeal-reflux-in-an-allergy-patient-population
#18
David L Brauer, Kevin Y Tse, Jane C Lin, Michael X Schatz, Ronald A Simon
BACKGROUND: Laryngopharyngeal reflux (LPR) is associated with asthma, vocal cord dysfunction, cough, postnasal drainage, and throat irritation. The Reflux Symptom Index (RSI) is a clinical tool to predict the presence of LPR, but a threshold RSI score has never been validated for the diagnosis of LPR in an allergic patient population. OBJECTIVE: To identify the optimal threshold RSI score predictive of LPR in an allergy clinic population. METHODS: The 9-question RSI questionnaire was administered to 84 patients in the Kaiser Permanente San Diego Allergy Department...
June 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28606726/patients-are-well-served-by-collis-gastroplasty-when-indicated
#19
Adam S Weltz, H Reza Zahiri, Udai S Sibia, Nan Wu, George T Fantry, Adrian E Park
BACKGROUND: Debate persists over the impact of Collis gastroplasty (CG) on outcomes after anti reflux surgery. This study analyzed operative and quality of life (QOL) outcomes from one of the largest series of laparoscopic anti reflux surgery (LARS) with CG reported to date. METHODS: A retrospective review was conducted to compare outcomes between patients undergoing LARS with CG versus without CG at two large centers with expertise in foregut surgery from October 2004-December 2011 and July 2012-September 2016...
September 2017: Surgery
https://www.readbyqxmd.com/read/28605121/do-laryngoscopic-findings-reflect-the-characteristics-of-reflux-in-patients-with-laryngopharyngeal-reflux
#20
Y C Lee, O E Kwon, J M Park, Y G Eun
OBJECTIVE: To analyse the association between 24-hour multichannel intraluminal impedance-pH (24-h MII-pH) parameters and each item of the reflux finding score (RFS) to determine whether the laryngoscopic findings of the RFS could reflect the characteristics of reflux in patients with laryngopharyngeal reflux (LPR). STUDY DESIGN: Prospective cohort study. SETTINGS: Tertiary care referral medical centre. PARTICIPANTS: Patients complaining of LPR symptoms were evaluated via a 24-hour MII-pH...
June 12, 2017: Clinical Otolaryngology
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