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https://www.readbyqxmd.com/read/27936396/gnpat-p-d519g-is-independently-associated-with-markedly-increased-iron-stores-in-hfe-p-c282y-homozygotes
#1
James C Barton, Wen-Pin Chen, Mary J Emond, Pradyumna D Phatak, V Nathan Subramaniam, Paul C Adams, Lyle C Gurrin, Gregory J Anderson, Grant A Ramm, Lawrie W Powell, Katrina J Allen, John D Phillips, Charles J Parker, Gordon D McLaren, Christine E McLaren
BACKGROUND: GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores. We sought to determine associations of p.D519G and iron-related variables with iron stores in p.C282Y homozygotes. METHODS: We defined markedly increased iron stores as serum ferritin >2247pmol/L (>1000μg/L) and either hepatic iron >236μmol/g dry weight or iron >10g by induction phlebotomy (men and women). We defined normal or mildly elevated iron stores as serum ferritin <674...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27936363/predictors-of-patterns-of-alcohol-related-blackouts-over-time-in-youth-from-the-collaborative-study-of-the-genetics-of-alcoholism-the-roles-of-genetics-and-cannabis
#2
Marc A Schuckit, Tom L Smith, Alexandra Shafir, Peyton Clausen, George Danko, Priscila Dib Gonçalves, Robert M Anthenelli, Grace Chan, Samuel Kuperman, Michie Hesselbrock, Victor Hesselbrock, John Kramer, Kathleen K Bucholz
OBJECTIVE: Alcohol-related blackouts (ARBs) are anterograde amnesias related to heavy alcohol intake seen in about 50% of drinkers. Although a major determinant of ARBs relates to blood alcohol concentrations, additional contributions come from genetic vulnerabilities and possible impacts of cannabis use disorders (CUDs). We evaluated relationships of genetics and cannabis use to latent class trajectories of ARBs in 829 subjects from the Collaborative Study of the Genetics of Alcoholism (COGA)...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936147/absence-of-association-between-behavior-problems-in-childhood-and-hypertension-in-midlife
#3
Sadiq M Saad, Gurch Randhawa, Dong Pang
BACKGROUND: It is known that behavior in childhood is associated with certain physical and mental health problems in midlife. However, there is limited evidence on the role of childhood behavior problems in the development of hypertension in adulthood. The present study aimed to examine whether behavior problems in childhood influenced the risk of hypertension in midlife in the United Kingdom 1958 birth cohort. METHODS: The 1958 British birth cohort comprised 17,638 individuals born in the first week of March 1958 in the United Kingdom...
2016: PloS One
https://www.readbyqxmd.com/read/27933201/association-between-metabolic-syndrome-and-liver-histology-among-nafld-patients-without-diabetes
#4
Pushpjeet Kanwar, James E Nelson, Katherine Yates, David E Kleiner, Aynur Unalp-Arida, Kris V Kowdley
BACKGROUND: Metabolic syndrome (MetS) and obesity are associated with non-alcoholic fatty liver disease (NAFLD). The aim of this observational study was to examine the relationship of MetS and a diagnosis of non-alcoholic steatohepatitis (NASH) in patients without diabetes in the NASH Clinical Research Network (CRN). METHODS: Clinical, demographic, histological, laboratory and anthropometric data were collected on 356 adult patients without diabetes with NAFLD. Obesity was defined as body mass index ≥30...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27932366/sauna-bathing-is-inversely-associated-with-dementia-and-alzheimer-s-disease-in-middle-aged-finnish-men
#5
Tanjaniina Laukkanen, Setor Kunutsor, Jussi Kauhanen, Jari Antero Laukkanen
BACKGROUND: there are no previous studies linking repeated heat exposure of sauna and the risk of memory diseases. We aimed to investigate whether frequency of sauna bathing is associated with risk of dementia and Alzheimer's disease. SETTING: prospective population-based study. METHODS: the frequency of sauna bathing was assessed at baseline in the Kuopio Ischaemic Heart Disease population-based prospective cohort study of 2,315 apparently healthy men aged 42-60 years at baseline, with baseline examinations conducted between 1984 and 1989...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932336/heat-stress-hydration-and-uric-acid-a-cross-sectional-study-in-workers-of-three-occupations-in-a-hotspot-of-mesoamerican-nephropathy-in-nicaragua
#6
Catharina Wesseling, Aurora Aragón, Marvin González, Ilana Weiss, Jason Glaser, Christopher J Rivard, Carlos Roncal-Jiménez, Ricardo Correa-Rotter, Richard J Johnson
OBJECTIVES: To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. DESIGN: Cross-sectional. SETTING: Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January-February 2013. PARTICIPANTS: 194 male workers aged 17-39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers. OUTCOME MEASURES: (1) Differences between the three occupational groups in prevalences/levels of socioeconomic, occupational, lifestyle and health risk factors for chronic kidney disease (CKD) and in biomarkers of kidney function and hydration; (2) differences in prevalences/levels of CKD risk factors between workers with reduced estimated glomerular filtration rate (eGFRCKD-EPI <80 mL/min/1...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932128/liver-transplantation-results-by-donor-age
#7
A V Rabelo, M D Bastante, A M Raya, C S M Méndez, A R G Ramirez, Y F Suarez
OBJECTIVE: The objective of this study was to compare liver transplantation outcomes as a function of donor age. MATERIAL AND METHODS: We performed 212 liver transplantations between 2008 and 2014. We described a prospective cohort study and grouped the patients by liver donor age. We compared quantitative and categorical variables using statistical analysis. RESULTS: No statistically significant differences were found among any graft age groups in gender (always more males), time on waiting list, age, height, Child Pugh Turcotte (CHILD) score, Model for End-stage Liver Disease (MELD) score, need for intraoperative blood products, or intensive care unit stay...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931691/risk-assessment-of-hepatotoxicity-among-tuberculosis-and-human-immunodeficiency-virus-aids-coinfected-patients-under-tuberculosis-treatment
#8
Williams Ngouleun, Prosper Cabral Biapa Nya, Anatole Constant Pieme, Phelix Bruno Telefo
OBJECTIVE/BACKGROUND: Tuberculosis (TB) is a worldwide public health problem. It is a contagious and grave disease caused by Mycobacterium tuberculosis. Current drugs such as isoniazid, pyrazinamide, and rifampicin used for the treatment of tuberculosis are potentially hepatotoxic and can lead to drug hepatitis. In order to improve the follow-up of TB patients in Cameroon, we carried out a study which aimed to evaluate the hepatotoxicity risk factors associated with anti-TB drugs. METHODS: The studies were performed on 75 participants who had visited the Loum District Hospital located in the littoral region of Cameroon for their routine consultation...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27930524/dietary-protein-and-fat-intake-in-relation-to-risk-of-colorectal-adenoma-in-korean
#9
Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
Consumption of red meat and alcohol are known risk factors for colorectal cancer, but associations for dietary fat remain unclear. We investigated the associations of dietary fat, protein, and energy intake with prevalence of colorectal adenoma.We performed a prospective cross-sectional study on asymptomatic persons who underwent a screening colonoscopy at a single center during a routine health check-up from May to December 2011. Dietary data were obtained via a validated Food Frequency Questionnaire (FFQ), assisted by a registered dietician...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928525/effects-of-alcohol-consumption-frequency-on-health-index-in-korean-women
#10
Hee-Ju Kwon, Ik-Rae Cho, Hyo-Joo Park, Tae-Young Kim
BACKGROUND: In this study, we examined the status of Korean women's alcohol consumption and identified the physical changes they undergo according to the level of consumption. The results of this study may thus be used as raw data to effectively control women' drinking habits. METHODS: This study consists of a secondary analysis using data from female participants in the 6(th) Korea National Health and Nutrition Examination Survey, which was conducted by the Korea Centers for Disease Control and Prevention(2013-2014, V-2)...
August 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27925118/alcohol-abuse-and-involvement-in-traffic-accidents-in-the-brazilian-population-2013
#11
Giseli Nogueira Damacena, Deborah Carvalho Malta, Cristiano Siqueira Boccolini, Paulo Roberto Borges de Souza, Wanessa da Silva de Almeida, Lucas Sisinno Ribeiro, Célia Landmann Szwarcwald
Abstract This article aims to analyze alcohol abuse and frequent consumption according to sociodemographic characteristics and investigate the risk of greater involvement in traffic accidents, using data from the National Health Survey (PNS), 2013, Brazil. Events investigated were alcohol abuse and frequent consumption and if the individual was involved in a traffic accident and sustained an injury in the last 12 months. We investigated both events according to sociodemographic characteristics and assessed the association among them through multivariate logistic regression...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27923628/association-between-total-serum-cholesterol-and-suicide-attempts-in-subjects-with-major-depressive-disorder-exploring-the-role-of-clinical-and-biochemical-confounding-factors
#12
Francesco Bartoli, Cristina Crocamo, Antonios Dakanalis, Ilaria Riboldi, Alessio Miotto, Enrico Brosio, Massimo Clerici, Giuseppe Carrà
OBJECTIVES: We tested whether serum total cholesterol levels might be associated with recent suicide attempts in subjects with major depressive disorder, after controlling for relevant individual characteristics. DESIGN AND METHODS: We conducted a comparative cross-sectional study including consecutive inpatients with major depressive disorder. We differentiated subjects admitted for a recent serious (violent or non-violent) suicide attempt and those without such recent history...
December 3, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27923200/a-quantitative-lc-ms-ms-method-for-simultaneous-determination-of-cocaine-and-its-metabolites-in-whole-blood
#13
Xiabin Chen, Xirong Zheng, Kai Ding, Ziyuan Zhou, Chang-Guo Zhan, Fang Zheng
As new metabolic pathways of cocaine were recently identified, a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously determine cocaine and nine cocaine-related metabolites in whole blood samples. One-step solid phase extraction was used to extract all of the ten compounds and corresponding internal standards from blood samples. All compounds and internal standards extracted were separated on an Atlantis T3 (100Å, 3μm, 2.1mm×150mm I.D) column and detected in positive ion and high sensitivity mode with multiple reaction monitoring...
November 11, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27922636/dna-methylation-and-substance-use-risk-a-prospective-genome-wide-study-spanning-gestation-to-adolescence
#14
C A M Cecil, E Walton, R G Smith, E Viding, E J McCrory, C L Relton, M Suderman, J-B Pingault, W McArdle, T R Gaunt, J Mill, E D Barker
Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or a consequence of substance use. Here, we believe we conducted the first genome-wide, longitudinal study to investigate whether DNA methylation patterns in early life prospectively associate with substance use in adolescence. The sample comprised of 244 youth (51% female) from the Avon Longitudinal Study of Parents and Children (ALSPAC), with repeated assessments of DNA methylation (Illumina 450k array; cord blood at birth, whole blood at age 7) and substance use (tobacco, alcohol and cannabis use; age 14-18)...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27921022/the-protective-effect-of-hydro-alcoholic-extract-of-mangrove-avicennia-marina-l-leaves-on-kidney-injury-induced-by-carbon-tetrachloride-in-male-rats
#15
Naser Mirazi, Seyedeh-Nahid Movassagh, Mahmoud Rafieian-Kopaei
BACKGROUND: Materials can cause liver and kidney damage which carbon tetrachloride is one of these substances. Medicinal plants and their essential oils and extracts have been used to a large extent as drugs to better control and management of kidney diseases. OBJECTIVES: The aim of this study was to investigate the effect of hydro-alcoholic extract of Avicennia marina leaves in the treatment of renal toxicity induced by carbon tetrachloride. METHODS: Forty-two male rats were randomly divided into 6 groups (n = 7): control (taking normal saline, 0...
October 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27919773/analgesic-effects-of-alcohol-a-systematic-review-and-meta-analysis-of-controlled-experimental-studies-in-healthy-participants
#16
REVIEW
Trevor Thompson, Charlotte Oram, Christoph U Correll, Stella Tsermentseli, Brendon Stubbs
: Despite the long-standing belief in the analgesic properties of alcohol, experimental studies have produced mixed results. This meta-analysis aimed to clarify whether alcohol produces a decrease in experimentally-induced pain and to determine the magnitude of any such effect. PubMed, PsycINFO and Embase databases were searched from inception until 21/4/2016 for controlled studies examining the effect of quantified dosages of alcohol on pain response to noxious stimulation. Eighteen studies involving 404 participants were identified providing alcohol vs...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27918951/subjective-alcohol-responses-in-a-cross-sectional-field-based-study-of-adolescents-and-young-adults-effects-of-age-drinking-level-and-dependence-consequences
#17
Hayley Treloar, Mark A Celio, Stephen A Lisman, Robert Miranda, Linda P Spear
BACKGROUND: Adolescents are physically, cognitively, socially, and emotionally different than adults in ways that may partially explain why alcohol misuse typically develops during this period. Ample animal-science evidence and nascent ecological evidence points toward developmentally limited differences in sensitivity to alcohol's stimulatory and sedative effects. Field-based research methods were used to test for such age-related differences in a sample of adolescents through young adults...
November 16, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27918475/association-between-the-osteoporosis-self-assessment-tool-for-asians-score-and-mortality-in-patients-with-isolated-moderate-and-severe-traumatic-brain-injury-a-propensity-score-matched-analysis
#18
Cheng-Shyuan Rau, Pao-Jen Kuo, Shao-Chun Wu, Yi-Chun Chen, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: The purpose of this study was to use a propensity score-matched analysis to investigate the association between the Osteoporosis Self-Assessment Tool for Asians (OSTA) scores and clinical outcomes of patients with isolated moderate and severe traumatic brain injury (TBI). Methods: The study population comprised 7855 patients aged ≥40 years who were hospitalized for treatment of isolated moderate and severe TBI (an Abbreviated Injury Scale (AIS) ≥3 points only in the head and not in other regions of the body) between 1 January 2009 and 31 December 2014...
December 3, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27917110/adolescent-mice-are-resilient-to-alcohol-withdrawal-induced-anxiety-and-changes-in-indices-of-glutamate-function-within-the-nucleus-accumbens
#19
Kaziya M Lee, Michal A Coelho, Hadley A McGregor, Noah R Solton, Matan Cohen, Karen K Szumlinski
Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental period of adolescence. In adult mice, a month-long history of binge-drinking elicits a hyper-glutamatergic state within the nucleus accumbens (Acb), coinciding with hyper-anxiety. Herein, we employed a murine model of binge-drinking to determine whether or not: (1) withdrawal-induced changes in brain and behavior differ between adult and adolescent bingers; and (2) increased behavioral signs of negative affect and changes in Acb expression of glutamate-related proteins would be apparent in adult mice with less chronic binge-drinking experience (14 days, approximating the duration of mouse adolescence)...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27916143/hyponatremia-effect-in-patients-with-alcohol-dependence-on-their-physical-and-mental-health-status
#20
Ordak Michal, Maj-Zurawska Magdalena, Matsumoto Halina, Bujalska-Zadrozny Magdalena, Nasierowski Tadeusz, Muszynska Elzbieta, Wojnar Marcin
Hyponatremia, i.e. reduction of sodium level in the blood plasma below 135 mmol/L, is one of the most common electrolyte disorders occurring in people addicted to alcohol. Numerous psychopathological symptoms may be significantly associated with its occurrence. Since sodium is one of the main bioelements, which is responsible for proper neuromuscular excitability maintenance and contributes in nerve impulses conduction, sodium balance disorders may be related to a risk to basic life functions. The tested group included 100 alcohol dependent patients (M = 90, F = 10)...
December 2016: Alcohol
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