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https://www.readbyqxmd.com/read/29785105/development-and-blood-compatibility-assessment-of-electrospun-polyvinyl-alcohol-blended-with-metallocene-polyethylene-and-plectranthus-amboinicus-pva-mpe-pa-for-bone-tissue-engineering
#1
Jie Qi, Huang Zhang, Yingzhou Wang, Mohan Prasath Mani, Saravana Kumar Jaganathan
Introduction: Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should not cause foreign body reactions. Materials and methods: In this study, the hybrid scaffold based on polyvinyl alcohol (PVA) blended with metallocene polyethylene (mPE) and plectranthus amboinicus (PA) was fabricated for bone tissue engineering via electrospinning...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29783922/lethal-phlegmonous-colitis
#2
John D Gilbert, Roger W Byard
A 52-year-old man died soon after admission to hospital with a severe metabolic acidosis and likely sepsis. He had a past history of alcohol abuse with withdrawal seizures. An abdominal computed tomography scan showed thickened bowel loops but no obvious ischaemic changes, and a blood culture yielded a pure growth of Escherichia coli. At autopsy, the liver showed well-established micro-nodular cirrhosis with steatosis. The peritoneal cavity contained 200 mL of turbid yellow-brown fluid, and the caecum and ascending colon were unusually thickened...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29783219/-clinical-and-laboratory-features-of-cholelithiasis-in-patients-with-type-2-diabetes-by-gender
#3
Natalya I Dyakiv-Koreiba
OBJECTIVE: Introduction: Today, diabetes is considered a factor that provokes the development of bile duct disease. Cholelithiasis is associated with such risk factors as aging, high body mass index, female sex, genetic predisposition, alcohol abuse, high concentration of triglycerides and cholesterol, low density lipoprotein in blood plasma The aim of the work is to analyze the clinical and laboratory features of the pathology of the gall bladder in patients with type 2 diabetes, depending on the sex...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782961/baclofen-induced-encephalopathy-in-overdose-modeling-of-the-electroencephalographic-effect-concentration-relationships-and-contribution-of-tolerance-in-the-rat
#4
Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard
Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. We designed a rat study to characterize baclofen-induced encephalopathy, correlate its severity with plasma concentrations and investigate the contribution of tolerance...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29780579/managing-portal-hypertension-in-patients-with-liver-cirrhosis
#5
REVIEW
Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka
Portal hypertension is one cause and a part of a dynamic process triggered by chronic liver disease, mostly induced by alcohol or incorrect nutrition and less often by viral infections and autoimmune or genetic disease. Adequate staging - continuously modified by current knowledge - should guide the prevention and treatment of portal hypertension with defined endpoints. The main goals are interruption of etiology and prevention of complications followed, if necessary, by treatment of these. For the past few decades, shunts, mostly as intrahepatic stent bypass between portal and hepatic vein branches, have played an important role in the prevention of recurrent bleeding and ascites formation, although their impact on survival remains ambiguous...
2018: F1000Research
https://www.readbyqxmd.com/read/29779409/acceptability-of-obtaining-hair-samples-for-assessing-antiretroviral-therapy-art-exposure-amongst-alcohol-drinking-art-recipients-in-tshwane-south-africa
#6
C T Kekwaletswe, S Nkosi, N B Kitleli, B Myers, P Shuper, C D H Parry, N K Morojele
To achieve the maximal therapeutic benefits of antiretroviral therapy (ART), high adherence is required. In South Africa, ART recipients are usually counselled by their health care providers to stop drinking alcohol, as heavy alcohol use compromises ART adherence. Patients who continue drinking alcohol tend to hide their alcohol-related adherence challenges from their health care providers. Objective measures of ART adherence/exposure may help to better identify drinkers who could benefit from ART adherence enhancement interventions...
May 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29778399/may-measurement-month-2017-an-analysis-of-blood-pressure-screening-results-worldwide
#7
Thomas Beaney, Aletta E Schutte, Maciej Tomaszewski, Cono Ariti, Louise M Burrell, Rafael R Castillo, Fadi J Charchar, Albertino Damasceno, Ruan Kruger, Daniel T Lackland, Peter M Nilsson, Dorairaj Prabhakaran, Agustin J Ramirez, Markus P Schlaich, Jiguang Wang, Michael A Weber, Neil R Poulter
BACKGROUND: Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. METHODS: This cross-sectional survey included volunteer adults (≥18 years) who ideally had not had their blood pressures measured in the past year...
May 16, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29778128/the-relationship-between-glycaemic-control-and-non-alcoholic-fatty-liver-disease-in-nigerian-type-2-diabetic-patients
#8
Babalola Ishmael Afolabi, Bolanle Olubunmi Ibitoye, Rosemary Temidayo Ikem, Adeleye Dorcas Omisore, Bukunmi Michael Idowu, David Olubukunmi Soyoye
BACKGROUND: Metabolic risk factors associated with non-alcoholic fatty liver disease (NAFLD) include Type 2 diabetes mellitus (T2DM), obesity and dyslipidaemia. Prevention or management of these risk factors with glycaemic control, weight reduction and low serum lipid levels respectively have been reported to reduce the risk of NAFLD or slow its progression. Since ultrasound (USS) is a safe and reliable method of identifying fatty changes in the liver, this study was done to determine the relationship between glycaemic control and ultrasound diagnosed NAFLD in T2DM...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29777589/low-adhesive-ethylene-vinyl-alcohol-based-packaging-to-xenogeneic-islets-encapsulation-for-type-1-diabetes-treatment
#9
Kai-Chiang Yang, Goichi Yanai, Sin-Yu Yang, Priyadarshini Canning, Yoshio Satou, Masako Kawagoe, Shoichiro Sumi
Transplantation of encapsulated porcine islets is proposed to treat type 1 diabetes. However, envelopment of fibrous tissue and infiltration of immune cells impair islets function and eventually cause implant failure. It is known that hemodialysis using an ethylene vinyl alcohol (EVOH) membrane results in minor tissue responses. Therefore, we hypothesized that using a low adhesive EVOH membrane for encapsulation may prevent host cell accumulation and fibrous capsule formation. In this study, rat islets suspended in chitosan gel were encapsulated in bags made from highly porous EVOH membranes, and their in vitro insulin secretion function as well as in vivo performance were evaluated...
May 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29776521/temporal-factors-in-motor-vehicle-crash-deaths-ten-years-later
#10
Rebecca Weast
OBJECTIVE: To assess trends in traffic fatalities on several temporal scales: year to year, by month, by day of week, and by time of day, to determine why some times correspond with higher rates of crash deaths, and to assess how these trends relate to age, the role of the deceased, and alcohol consumption. METHOD: Traffic fatalities were identified using the Fatality Analysis Reporting System (FARS) for 1998 through 2014 and assessed for their time of occurrence...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29776517/fatally-injured-pedestrians-and-bicyclists-in-the-united-states-with-high-blood-alcohol-concentrations
#11
Angela H Eichelberger, Anne T McCartt, Jessica B Cicchino
INTRODUCTION: Little research has focused on the problem of alcohol impairment among pedestrians and bicyclists in the United States. The aim of the current study was to investigate the prevalence, trends, and characteristics of alcohol-impaired fatally injured pedestrians and bicyclists. METHOD: Data from the Fatality Analysis Reporting System (FARS) were analyzed for fatally injured passenger vehicle drivers, pedestrians, and bicyclists 16 and older during 1982-2014...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29775206/prospective-determination-of-aspirin-sensitivity-in-patients-resistant-to-low-dose-aspirin-a-proof-of-concept-study
#12
Erica S Westphal, Michelle Rainka, Michelle Amsler, Traci Aladeen, Caitlin Wisniewski, Vernice Bates, Fran M Gengo
This study tested the capability of an assay to predict aspirin response and reduce ischemic events, and healthcare costs, and delays to optimal treatment. Patients who needed aspirin in the course of normal medical care were included. Patients were excluded if they had disorders affecting platelet function, alcohol use within 24 hours of a test, or NSAID use. Dose escalation of chewable aspirin from 81 mg, to 162 mg, to 325 mg daily occurred based on the results of whole blood impedance aggregation testing to the agonists, collagen (1ug/mL, 5 ug/mL) and arachidonate (0...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29773783/cholesteryl-ester-storage-disease-fatal-outcome-without-causal-therapy-in-a-female-patient-with-the-preventable-sequelae-of-progressive-liver-disease-after-many-years-of-mild-symptoms
#13
Ali Canbay, Meike N Müller, Stathis Philippou, Guido Gerken, Andreas Tromm
BACKGROUND Cholesteryl ester storage disease (CESD), also known as lysosomal acid lipase deficiency (LAL-D), is a rare autosomal-recessive inheritable lysosomal storage disease. Since 2015, a causal treatment with sebelipase alfa, which replaces the missing LAL enzyme, has been approved. We report a fatal course of LAL-D in a female patient. CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly. At that time, no specific treatment for CESD was available and the spontaneous course of the disease had to be awaited...
May 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29773209/prevalence-and-risk-factors-of-type-2-diabetes-in-insomnia-sufferers-a-study-on-1311-individuals-referred-for-sleep-examinations
#14
Matthieu Hein, Jean-Pol Lanquart, Gwénolé Loas, Philippe Hubain, Paul Linkowski
BACKGROUND: Several studies have investigated the particular relationship between insomnia and type 2 diabetes. However, few studies have investigated the prevalence and risk factors for type 2 diabetes in insomnia sufferers. The aim of this study was to examine the prevalence and risk factors of type 2 diabetes in a large sample of insomnia sufferers. METHODS: Data from 1311 insomnia sufferers recruited from the research database of the Erasme Hospital sleep laboratory were analyzed...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29771944/intraocular-pressure-and-its-normal-range-adjusted-for-ocular-and-systemic-parameters-the-beijing-eye-study-2011
#15
Ya Xing Wang, Liang Xu, Wen Bin Wei, Jost B Jonas
PURPOSE: To examine the distribution of intraocular pressure (IOP) in a normal population and the associations of IOP with other ocular and systemic parameters. METHODS: Out of 3468 participants of the population-based cross-sectional Beijing Eye Study 2011 we selected those individuals without glaucomatous optic neuropathy. The study particpants underwent a detailed ophthalmologic and systemic examination. IOP was measured by air puff non-contact tonometry. RESULTS: The study included 3135 eyes of 3135 participants with a mean age of 64...
2018: PloS One
https://www.readbyqxmd.com/read/29770358/association-of-central-obesity-with-sex-hormonebinding-globulin-a-cross-sectional-study-of-1166-chinese-men
#16
Fangwei Liu, Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Shimin Xiong, Chengliang Xiong, Yuanzhong Zhou
Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29768343/potential-common-factors-associated-with-predisposition-to-common-cold-in-middle-aged-and-elderly-japanese-a-community-based-cross-sectional-study
#17
Michi Shibata, Taizo Iwane, Ryoko Higuchi, Kaname Suwa, Kei Nakajima
People worldwide frequently catch a common cold, which occasionally develops into secondary severe conditions such as pneumonia. However, it is unclear whether predisposition to the common cold is associated with the individual's characteristics including age, body weight, lifestyles, diets, and intestinal functions, besides exposure to a responsible pathogen. We addressed this issue epidemiologically considering many relevant clinical factors.We reviewed data from a cross-sectional study consisting of 39,524 apparently healthy Japanese aged 40 to 79 years (26,975 men and 12,549 women) who underwent a checkup in 2007...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764270/drunk-decisions-alcohol-shifts-choice-from-habitual-towards-goal-directed-control-in-adolescent-intermediate-risk-drinkers
#18
Elisabeth Obst, Daniel J Schad, Quentin Jm Huys, Miriam Sebold, Stephan Nebe, Christian Sommer, Michael N Smolka, Ulrich S Zimmermann
BACKGROUND: Studies in humans and animals suggest a shift from goal-directed to habitual decision-making in addiction. We therefore tested whether acute alcohol administration reduces goal-directed and promotes habitual decision-making, and whether these effects are moderated by self-reported drinking problems. METHODS: Fifty-three socially drinking males completed the two-step task in a randomised crossover design while receiving an intravenous infusion of ethanol (blood alcohol level=80 mg%), or placebo...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#19
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#20
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
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