keyword
https://read.qxmd.com/read/37259298/piperine-chlorogenic-acid-hybrid-inhibits-the-proliferation-of-the-sk-mel-147-melanoma-cells-by-modulating-mitotic-kinases
#21
JOURNAL ARTICLE
Carolina Girotto Pressete, Flávia Pereira Dias Viegas, Thâmara Gaspar Campos, Ester Siqueira Caixeta, João Adolfo Costa Hanemann, Guilherme Álvaro Ferreira-Silva, Bruno Zavan, Alexandre Ferro Aissa, Marta Miyazawa, Claudio Viegas, Marisa Ionta
Melanoma is considered the most aggressive form of skin cancer, showing high metastatic potential and persistent high mortality rates despite the introduction of immunotherapy and targeted therapies. Thus, it is important to identify new drug candidates for melanoma. The design of hybrid molecules, with different pharmacophore fragments combined in the same scaffold, is an interesting strategy for obtaining new multi-target and more effective anticancer drugs. We designed nine hybrid compounds bearing piperine and chlorogenic acid pharmacophoric groups and evaluated their antitumoral potential on melanoma cells with distinct mutational profiles SK-MEL-147, CHL-1 and WM1366...
January 19, 2023: Pharmaceuticals
https://read.qxmd.com/read/37191806/illuminating-depdc1b-in-multi-pronged-regulation-of-tumor-progression
#22
JOURNAL ARTICLE
Howard E Boudreau, Jennifer Robinson, Usha N Kasid
DEPDC1B (aliases BRCC3, XTP8, XTP1) is a DEP (Dishevelled, Egl-1, Pleckstrin) and Rho-GAP-like domains containing predominately membrane-associated protein. Earlier, we and others have reported that DEPDC1B is a downstream effector of Raf-1 and long noncoding RNA lncNB1, and an upstream positive effector of pERK. Consistently, DEPDC1B knockdown is associated with downregulation of ligand-stimulated pERK expression. We demonstrate here that DEPDC1B N-terminus binds to the p85 subunit of PI3K, and DEPDC1B overexpression results in decreased ligand-stimulated tyrosine phosphorylation of p85 and downregulation of pAKT1...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/37180139/immunological-role-and-prognostic-value-of-the-ska-family-in-pan-cancer-analysis
#23
JOURNAL ARTICLE
Zhengtian Li, Lanying Huang, Jiachen Li, Wenkang Yang, Weichao Li, Qiuzhong Long, Xinyu Dai, Hongtao Wang, Gang Du
BACKGROUND: The spindle and kinetochore associated (SKA) complex, which plays important roles in proper chromosome segregation during mitosis by maintaining the stabilization of kinetochore-spindle microtubule attachment during mitosis, has recently been reported to exert regulatory effects on the initiation and progression of various human cancer types. Nevertheless, the prognostic significance and immune infiltration of the SKA family across cancers have not been well elucidated. METHODS: Using data from three large public datasets, including The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus databases, a novel scoring system (termed the SKA score) was developed to quantify the SKA family level across cancers...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37162404/the-prognostic-role-of-mitotic-rate-in-cutaneous-malignant-melanoma-evidence-from-a-multicenter-study-on-behalf-of-the-italian-melanoma-intergroup
#24
JOURNAL ARTICLE
Roberto Patuzzo, Ilaria Mattavelli, Gianfranco Gallino, Carlotta Galeone, Barbara Valeri, Simone Mocellin, Paolo Del Fiore, Simone Ribero, Mario Mandalà, Francesca Tauceri, Maurizio Lombardo, Andrea Maurichi
BACKGROUND: This study aimed to improve the understanding of the prognostic value of tumor mitotic rate (TMR) in cutaneous melanoma and assessed its significance as a predictor for overall, melanoma-specific, and recurrence-free survival. PATIENTS AND METHODS: This is a retrospective multicenter Italian cohort study of 13,016 patients diagnosed with and treated for invasive primary melanoma between 2005 and 2020 with median follow-up of 5.5 years. The survival probability was assessed by Kaplan-Meier method, hazard ratios (HRs), and corresponding 95% confidence interval (CI) of all-cause mortality and recurrence/death by multivariable Cox proportional hazards models...
May 10, 2023: Cancer
https://read.qxmd.com/read/37061649/the-use-of-indocyanine-green-and-near-infrared-fluorescence-imaging-versus-blue-dye-in-sentinel-lymph-node-biopsy-in-cutaneous-melanoma-a-retrospective-cohort-study
#25
JOURNAL ARTICLE
Michael G Fadel, Sidra Rauf, Hesham S Mohamed, Siraj Yusuf, Andrew J Hayes, Kieran Power, Myles J Smith
BACKGROUND: The use of indocyanine green (ICG) and near-infrared fluorescence imaging is a promising option for sentinel lymph node (SLN) mapping in cutaneous melanoma. The study objective was to compare the performance of ICG and blue dye at detecting SLNs with radioisotope nanocolloid (technetium-99). METHODS: Between April 2018 and June 2022, 293 consecutive patients with cutaneous melanoma (Breslow thickness ≥ 0.8 mm) underwent wide local excision and SLN biopsy...
July 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36937164/short-brown-parallel-lines-on-the-proximal-nail-fold-clinical-dermoscopic-histologic-correlation-of-a-melanocytic-nevus-of-the-eponychium
#26
Judit Algarra-Sahuquillo, Daniel Ramos-Rodríguez, María-Luísa Santos-E-Silva Caldeira-Marques, Júlia Mercader-Salvans, Rosa-Nieves Rodríguez-Rodríguez, Carmen-Nieves Hernández-León, Francisco Guimerá Martin-Neda
INTRODUCTION: Although Hutchinson's sign can appear associated with benign conditions, dermoscopic findings of non-melanoma eponychium pigmentation have not yet been described in the literature. We report for the first time to our knowledge the dermoscopic findings of an acral nevus located in the proximal nail fold as well as its clinical-dermoscopic-histologic correlation. CASE REPORT: A twenty-year-old patient presented with a homogeneous longitudinal melanonychia on the left-hand thumb, with benign dermoscopic pattern, and an irregular, 6-mm, dark-brown hyperpigmented macule on the adjacent eponychium (Hutchinson's sign)...
March 2023: Skin Appendage Disorders
https://read.qxmd.com/read/36935433/the-association-of-guideline-concordant-sentinel-lymph-node-biopsy-for-melanoma-at-minority-serving-hospitals
#27
JOURNAL ARTICLE
Alicia C Greene, William G Wong, Rolfy A Perez Holguin, Akshilkumar Patel, Colette R Pameijer, Chan Shen
BACKGROUND: Minority-serving hospitals (MSHs) have been associated with lower guideline adherence and worse outcomes for various cancers. However, the relationship among MSH status, concordance with sentinel lymph node biopsy (SLNB) guidelines, and overall survival (OS) for patients with cutaneous melanoma is not well studied. METHODS: The National Cancer Database was queried for patients diagnosed with T1a*, T2, and T3 melanoma between 2012 and 2017. MSHs were defined as the top decile of institutions ranked by the proportion of minorities treated for melanoma...
March 19, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36768289/resistance-to-braf-inhibitors-ezh2-and-its-downstream-targets-as-potential-therapeutic-options-in-melanoma
#28
JOURNAL ARTICLE
Anne Uebel, Stefanie Kewitz-Hempel, Edith Willscher, Kathleen Gebhardt, Cord Sunderkötter, Dennis Gerloff
Activating BRAF mutations occurs in 50-60% of malignant melanomas. Although initially treatable, the development of resistance to BRAF-targeted therapies (BRAFi) is a major challenge and limits their efficacy. We have previously shown that the BRAFV600E signaling pathway mediates the expression of EZH2, an epigenetic regulator related to melanoma progression and worse overall survival. Therefore, we wondered whether inhibition of EZH2 would be a way to overcome resistance to vemurafenib. We found that the addition of an EZH2 inhibitor to vemurafenib improved the response of melanoma cells resistant to BRAFi with regard to decreased viability, cell-cycle arrest and increased apoptosis...
January 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36761025/case-report-surgery-to-remove-adrenocortical-oncocytic-carcinoma-from-an-asian-male
#29
Hongtao Liu, Kai Huang, Dan Liu, Yehua Wang
Adrenocortical oncocytic carcinoma is a rare type of adrenocortical tumor. Its clinical characteristics and biological behavior need to be further evaluated after the accumulation of cases. Here we report a case of adrenocortical oncocytic carcinoma in an Asian male with scoliosis. We performed an operation on this patient. Because the patient's scoliosis was limited during the operation and the tumor protruded into the chest, we decided to adopt open surgery in the supine position. During the operation, we found a tumor about 8 cm in diameter in the right adrenal region and successfully removed it...
2023: Frontiers in Surgery
https://read.qxmd.com/read/36722142/inhibition-of-the-mnk1-2-eif4e-axis-augments-palbociclib-mediated-antitumor-activity-in-melanoma-and-breast-cancer
#30
JOURNAL ARTICLE
Sathyen A Prabhu, Omar Moussa, Christophe Gonçalves, Judith H LaPierre, Hsiang Chou, Fan Huang, Vincent R Richard, Pault Y M Ferruzo, Elizabeth M Guettler, Isabel Soria-Bretones, Laura Kirby, Natascha Gagnon, Jie Su, Jennifer Silvester, Sai Sakktee Krisna, April A N Rose, Karen E Sheppard, David W Cescon, Frédérick A Mallette, Rene P Zahedi, Christoph H Borchers, Sonia V Del Rincon, Wilson H Miller
Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their use as single agents in melanoma has shown limited clinical benefit. Herein, we discovered that treatment of tumor cells with palbociclib induces the phosphorylation of the mRNA translation initiation factor eIF4E. When phosphorylated, eIF4E specifically engenders the translation of mRNAs that code for proteins involved in cell survival...
February 1, 2023: Molecular Cancer Therapeutics
https://read.qxmd.com/read/36705261/lymphoscintigraphy-using-tilmanocept-detects-multiple-sentinel-lymph-nodes-in-melanoma-patients
#31
JOURNAL ARTICLE
Daniel M Balkin, Gregory J Tranah, Frederick Wang, Cristina O'Donoghue, Emily A Morell, Caitlin Porubsky, Mehdi Nosrati, Edith M Vaquero, HanKyul Kim, Michael J Carr, Jaime L Montilla-Soler, Max C Wu, Donald M Torre, Mohammed Kashani-Sabet, Jonathan S Zager, Stanley P Leong
BACKGROUND: Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells which are abundantly present in lymph nodes. We want to examine the drainage patterns of Technetium-99m-labeled Tilmanocept to sentinel lymph nodes (SLNs) in melanoma patients following the 10% rule. METHODS: Multi-center retrospective review of patients with cutaneous melanoma undergoing SLN biopsy using Technetium-99m-labeled Tilmanocept between 2008 and 2014 was conducted...
2023: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/36482443/per-and-polyfluoroalkyl-substances-pfas-exposure-in-melanoma-patients-a-retrospective-study-on-prognosis-and-histological-features
#32
JOURNAL ARTICLE
Paolo Del Fiore, Francesco Cavallin, Marcodomenico Mazza, Clara Benna, Alessandro Dal Monico, Giulia Tadiotto, Irene Russo, Beatrice Ferrazzi, Saveria Tropea, Alessandra Buja, Claudia Cozzolino, Rocco Cappellesso, Lorenzo Nicolè, Luisa Piccin, Jacopo Pigozzo, Vanna Chiarion-Sileni, Antonella Vecchiato, Chiara Menin, Franco Bassetto, Angelo Paolo Dei Tos, Mauro Alaibac, Simone Mocellin
Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals which could be associated with cancer development, such as kidney and testicular cancers, pancreatic and hepatocellular carcinoma and thyroid tumor. Available scientific literature offers no information on the role of PFAS in melanoma development/progression. Since 1965, a massive environmental contamination by PFAS has occurred in northeastern Italy. This study compared histopathology and prognosis between melanoma patients exposed (n = 194) and unexposed (n = 488) to PFAS...
December 9, 2022: Environmental Health
https://read.qxmd.com/read/36317389/the-importance-of-mitosis-%C3%A2-2-in-selecting-patients-with-t1-cutaneous-melanomas-for-sentinel-lymph-node-biopsy
#33
JOURNAL ARTICLE
Lorenzo Borgognoni, Emanuele Crocetti, Serena Sestini, Paola Brandani, Vanni Giannotti, Gianni Gerlini
The 8th Edition of the American Joint Committee on Cancer (AJCC) Staging Manual removed the mitotic rate (MR) as a staging criterion for T1 melanomas, thus leading to a debate on sentinel lymph node biopsy (SLNB) in thin melanomas. This study investigates whether MR plays a role in selecting patients with T1 melanoma for SLNB. We analyzed clinical and histological data from the Florence Melanoma & Skin Cancer Unit database for 313 patients with a single thin melanoma who had undergone SLNB. We determined sentinel lymph node (SLN) positivity percentages in T1 melanomas according to the AJCC 8th Edition focusing on MR...
December 1, 2022: Melanoma Research
https://read.qxmd.com/read/36297281/design-and-synthesis-of-aminopyrimidinyl-pyrazole-analogs-as-plk1-inhibitors-using-hybrid-3d-qsar-and-molecular-docking
#34
JOURNAL ARTICLE
Swapnil P Bhujbal, Hyejin Kim, Hyunah Bae, Jung-Mi Hah
Cancer continues to be one of the world's most severe public health issues. Polo-like kinase 1 (PLK1) is one of the most studied members of the polo-like kinase subfamily of serine/threonine protein kinases. PLK1 is a key mitotic regulator responsible for cell cycle processes, such as mitosis initiation, bipolar mitotic spindle formation, centrosome maturation, the metaphase to anaphase transition, and mitotic exit, whose overexpression is often associated with oncogenesis. Moreover, it is also involved in DNA damage response, autophagy, cytokine signaling, and apoptosis...
September 21, 2022: Pharmaceuticals
https://read.qxmd.com/read/36204597/automated-analysis-of-whole-slide-digital-skin-biopsy-images
#35
JOURNAL ARTICLE
Shima Nofallah, Wenjun Wu, Kechun Liu, Fatemeh Ghezloo, Joann G Elmore, Linda G Shapiro
A rapidly increasing rate of melanoma diagnosis has been noted over the past three decades, and nearly 1 in 4 skin biopsies are diagnosed as melanocytic lesions. The gold standard for diagnosis of melanoma is the histopathological examination by a pathologist to analyze biopsy material at both the cellular and structural levels. A pathologist's diagnosis is often subjective and prone to variability, while deep learning image analysis methods may improve and complement current diagnostic and prognostic capabilities...
2022: Frontiers in artificial intelligence
https://read.qxmd.com/read/36200765/ulceration-vs-mitosis-in-cutaneous-melanoma-which-is-superior-for-predicting-prognosis-across-clinical-stages
#36
JOURNAL ARTICLE
Faruk Tas, Kayhan Erturk
Ulceration and high mitosis are considered among the major unfavorable prognostic factors in the survival of cutaneous melanoma patients. The aim of this study was to investigate the clinical significance of these parameters and to compare them to see which one is superior to predicting prognosis across all clinical stages of melanoma. A total of 1,074 melanomas were analyzed retrospectively. Tumor ulceration was found to be limited to the local stage for predicting survival, whereas, mitosis maintained its prognostic strength for predicting survival across all clinical stages...
October 6, 2022: Cancer Investigation
https://read.qxmd.com/read/35906811/melanocytic-matricoma-with-atypical-features-a-case-of-malignant-melanocytic-matricoma
#37
JOURNAL ARTICLE
Gabriella J Melson, Sophiette G Hong, Candice E Brem
Melanocytic matricoma is a rarely reported, benign cutaneous adnexal neoplasm composed of epithelial cells exhibiting differentiation towards hair matrix as well as admixed, pigmented, dendritic melanocytes. The proposed malignant counterpart to melanocytic matricoma, malignant melanocytic matricoma (MMM), is even more rare. Here we report a case of a melanocytic matricoma with atypical features in a 92-year-old female with a 1.2-cm pigmented nodule on the right nasal sidewall. Histopathology revealed a well-circumscribed dermal tumor composed of atypical matrical cells with scattered aggregates of anucleate keratinocytes (ghost cells), prominent intratumoral pigment, numerous mitotic figures (88 mitosis/10 high-power field [HPF]), and intermixed dendritic melanocytes...
July 30, 2022: Journal of Dermatology
https://read.qxmd.com/read/35870015/aurka-is-a-prognostic-potential-therapeutic-target-in-skin-cutaneous-melanoma-modulating-the-tumor-microenvironment-apoptosis-and-hypoxia
#38
JOURNAL ARTICLE
ShengYong Long, Xuan Fen Zhang
BACKGROUND: AURKA, Aurora kinase A encoding gene, is an important signaling hub gene for mitosis. In recent years, AURKA has been implicated in the occurrence and development of several cancers. However, its relationship with the tumor microenvironment in skin cutaneous melanoma (SKCM) and the molecular mechanisms underlying its effects are still unclear. METHOD: We adopted a variety of bioinformatics methods to comprehensively analyze the potential carcinogenesis of AURKA in SKCM, and constructed a prognostic nomogram model...
July 23, 2022: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/35685361/integrative-rna-profiling-of-tbev-infected-neurons-and-astrocytes-reveals-potential-pathogenic-effectors
#39
JOURNAL ARTICLE
Martin Selinger, Pavlína Věchtová, Hana Tykalová, Petra Ošlejšková, Michaela Rumlová, Ján Štěrba, Libor Grubhoffer
Tick-borne encephalitis virus (TBEV), the most medically relevant tick-transmitted flavivirus in Eurasia, targets the host central nervous system and frequently causes severe encephalitis. The severity of TBEV-induced neuropathogenesis is highly cell-type specific and the exact mechanism responsible for such differences has not been fully described yet. Thus, we performed a comprehensive analysis of alterations in host poly-(A)/miRNA/lncRNA expression upon TBEV infection in vitro in human primary neurons (high cytopathic effect) and astrocytes (low cytopathic effect)...
2022: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/35676603/predictors-of-sentinel-lymph-node-metastasis-in-patients-with-thin-melanoma-an-international-multi-institutional-collaboration
#40
MULTICENTER STUDY
Richard J B Walker, Nicole J Look Hong, Marc Moncrieff, Alexander C J van Akkooi, Evan Jost, Carolyn Nessim, Winan J van Houdt, Emma H A Stahlie, Chanhee Seo, May Lynn Quan, J Gregory McKinnon, Frances C Wright, Michail N Mavros
BACKGROUND: Consideration of sentinel lymph node biopsy (SLNB) is recommended for patients with T1b melanomas and T1a melanomas with high-risk features; however, the proportion of patients with actionable results is low. We aimed to identify factors predicting SLNB positivity in T1 melanomas by examining a multi-institutional international population. METHODS: Data were extracted on patients with T1 cutaneous melanoma who underwent SLNB between 2005 and 2018 at five tertiary centers in Europe and Canada...
October 2022: Annals of Surgical Oncology
keyword
keyword
87274
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.