keyword
https://read.qxmd.com/read/38547465/tackling-access-and-payer-barriers-for-growth-hormone-therapy-in-saudi-arabia-a-consensus-statement-for-the-saudi-working-group-for-pediatric-endocrinology
#1
REVIEW
Najya Attia, Khairya Moussa, Abdulaziz Altwaim, Abdulmoein Eid Al-Agha, Ashraf A Amir, Aseel Almuhareb
Prompt diagnosis and early treatment are key goals to optimize the outcomes of children with growth hormone deficiency (GHD) and attain the genetically expected adult height. Nonetheless, several barriers can hinder prompt diagnosis and treatment of GHD, including payer-related issues. In Saudi Arabia, moderate-to-severe short stature was reported in 13.1 and 11.7 % of healthy boys and girls, respectively. Several access and payer barriers can face pediatric endocrinologists during the diagnosis and treatment of GHD in Saudi Arabia...
March 29, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38547219/retraction-disruption-of-growth-hormone-receptor-prevents-calorie-restriction-from-improving-insulin-action-and-longevity
#2
(no author information available yet)
No abstract text is available yet for this article.
2024: PloS One
https://read.qxmd.com/read/38546339/an-asynchronous-double-growth-hormone-secreting-pituitary-neoplasm-pitnet-of-a-different-proliferative-potential
#3
JOURNAL ARTICLE
Małgorzata Trofimiuk-Müldner, Bartosz Domagała, Maria Maksymowicz, Monika Pękul, Grzegorz Zieliński, Alicja Hubalewska-Dydejczyk
No abstract text is available yet for this article.
March 28, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38540684/exploring-fda-approved-frontiers-insights-into-natural-and-engineered-peptide-analogues-in-the-glp-1-gip-ghrh-cck-acth-and-%C3%AE-msh-realms
#4
REVIEW
Othman Al Musaimi
Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 peptides for various applications. Peptides, although initially derived from endogenous sources, have evolved beyond their natural origins, exhibiting favourable therapeutic effectiveness. Medicinal chemistry has played a pivotal role in synthesising valuable natural peptide analogues, providing synthetic alternatives with therapeutic potential...
February 22, 2024: Biomolecules
https://read.qxmd.com/read/38540126/the-hormonal-background-of-hair-loss-in-non-scarring-alopecias
#5
REVIEW
Barbara Owecka, Agata Tomaszewska, Krzysztof Dobrzeniecki, Maciej Owecki
Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation of the hair growth cycle. This review focuses on the hormonal background of hair loss, including pathophysiology, underlying endocrine disorders, and possible treatment options for alopecia. In particular, the role of androgens, including dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS), has been studied in the context of androgenetic alopecia...
February 24, 2024: Biomedicines
https://read.qxmd.com/read/38539988/progesterone-related-diabetes-mellitus-in-the-bitch-current-knowledge-the-role-of-pyometra-and-relevance-in-practice
#6
REVIEW
Álan Gomes Pöppl, José Lucas Xavier Lopes, Taís Bock Nogueira, Denise Iparraguirre da Silva, Bruna Dos Santos Machado
Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. This narrative review aims to provide relevant detailed information on (1) the canine estrus cycle and its impact on canine diabetes mellitus (CDM) etiology and management, (2) the role of pyometra as a further cause of insulin resistance, and (3) useful individual therapeutic and preventive strategies. PRDM is recognized due to diestrus, exogenous progestogen exposure, pregnancy, and P4-production ovarian dysfunction...
March 14, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539932/single-nucleotide-polymorphisms-of-growth-hormone-gene-and-its-relationship-with-growth-traits-in-black-bengal-goats
#7
JOURNAL ARTICLE
Chollada Buranakarl, Sumonwan Chamsuwan, Sumpun Thammacharoen, Panupat Ratchakom, Natthaya Chuaypen
The single-nucleotide polymorphisms (SNPs) of the growth hormone (GH) gene could be related to growth traits, particularly in farm animals. This study aimed to identify the SNPs of the GH gene (A781G and A1575G) in Black Bengal (BB) goats in Thailand. Seventy-seven BB goats of both sexes were recruited, and their genotypes were identified. Preweaning growth at birth (weight, W0; height, H0; length, L0; and chest girth, C0) and at 10 weeks postpartum (W10, H10, L10, and C10), including average daily gain (ADG) at 0-4 weeks (ADG0-4W), 4-8 weeks (ADG4-8W), and 8-12 weeks (ADG8-12W), was compared among the different genotypes in goats born from twin litter-size dams...
March 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38538470/diagnosis-and-management-of-congenital-hypopituitarism-in-children
#8
Sarah Castets, Cécile Thomas-Teinturier, Carine Villanueva, Jessica Amsellem, Pascal Barat, Gilles Brun, Emmanuel Bui Quoc, Jean-Claude Carel, Gian Paolo De Filippo, Clara Kipnis, Laetitia Martinerie, Julia Vergier, Alexandru Saveanu, Natacha Teissier, Régis Coutant, Juliane Léger, Rachel Reynaud
Hypopituitarism (or pituitary deficiency) is a rare disease with an estimated prevalence of between 1/16,000 and 1/26,000 individuals, defined by insufficient production of one or several anterior pituitary hormones (growth hormone [GH], thyroid-stimulating hormone [TSH], adrenocorticotropic hormone [ACTH], luteinizing hormone [LH], follicle-stimulating hormone [FSH], prolactin), in association or not with diabetes insipidus (antidiuretic hormone [ADH] deficiency). While in adults hypopituitarism is mostly an acquired disease (tumors, irradiation), in children it is most often a congenital condition, due to abnormal pituitary development...
March 26, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/38536564/metabolic-consequences-of-anabolic-steroids-insulin-and-growth-hormone-abuse-in-recreational-bodybuilders-implications-for-the-world-anti-doping-agency-passport
#9
JOURNAL ARTICLE
Filippo Giorgio Di Girolamo, Chiara Biasinutto, Alessandro Mangogna, Nicola Fiotti, Pierandrea Vinci, Rado Pisot, Filippo Mearelli, Bostjan Simunic, Chiara Roni, Gianni Biolo
BACKGROUND: Hormonal doping in recreational sports is a public-health concern. The World Anti-Doping Agency (WADA) promoted the creation of the Athlete Biological Passport, aiming to monitor athlete's biological variables over time to facilitate indirect detection of doping. Detection tests for anabolic androgenic steroids (AAS) and growth hormone (GH) are available while insulin abuse cannot be revealed. We have determined in recreational bodybuilders the metabolic effects associated with different patterns of hormone abuse...
March 27, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38536548/bone-mineral-density-in-adults-growth-hormone-deficiency-with-different-ages-of-onset-a-real-world-retrospective-study
#10
JOURNAL ARTICLE
Hongbo Yang, Meiping Chen, Hanyuan Xu, Yunfeng Zhen, Yuelun Zhang, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan
PURPOSE: Bone mineral density (BMD) impairment is one of the critical factors for long-term quality of life in adults growth hormone deficiency (AGHD). This study aims to investigate the annual changes in BMD in AGHD patients with different ages of onset and to identify predicting factors that influence BMD. METHODS: AGHD patients (n = 160) with available data for 4 years follow-up from a major tertiary medical center in China were retrospectively included (110 [68...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38535731/acute-hemodynamic-metabolic-and-hormonal-responses-to-a-boxing-exergame-with-and-without-blood-flow-restriction-in-non-athlete-young-individuals
#11
JOURNAL ARTICLE
Zohreh Karimi, Zeynabalsadat Mousavi, Michael Nordvall, Alexei Wong, Reza Bagheri, Frederic Dutheil
BACKGROUND: This study aimed to compare acute hemodynamic, metabolic (glucose and blood lactate concentrations), hormonal (growth hormone and normetanephrine), heart rate variability (HRV), and rating of perceived exertion (RPE) responses before and after bouts of a boxing exergame with and without blood flow restriction (BFR) in non-athlete young individuals. METHODS: Fourteen participants (age: 30 ± 10 y; BMI: 21 ± 3 kg.m-2 ) participated in two sessions of a 20 min boxing exergame...
February 23, 2024: Sports
https://read.qxmd.com/read/38534468/advances-in-the-development-of-biofertilizers-and-biostimulants-from-microalgae
#12
REVIEW
Alejandra M Miranda, Fabian Hernandez-Tenorio, Fabian Villalta, Gabriel J Vargas, Alex A Sáez
Microalgae have commercial potential in different sectors of the industry. Specifically in modern agriculture, they can be used because they have the ability to supply nutrients to the soil and produce plant growth hormones, polysaccharides, antimicrobial compounds, and other metabolites that improve agricultural productivity. Therefore, products formulated from microalgae as biofertilizers and biostimulants turn out to be beneficial for agriculture and are positioned as a novel and environmentally friendly strategy...
March 21, 2024: Biology
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#13
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38532845/acute-response-in-circulating-micrornas-following-a-single-bout-of-short-sprint-and-heavy-strength-training-in-well-trained-cyclists
#14
JOURNAL ARTICLE
Anita Ryningen, Kari Rostad, Elisabeth Ersvær, Gry Sjøholt, Gøran Paulsen, Hilde Gundersen, Morten Kristoffersen, Lise Bjørkhaug
Background: Heavy strength (HS) and short-sprint (SS) are commonly used training methods for competitive road cyclists, with the aim to improve the anaerobic power and short time cycling performance. Knowledge of how such training methods affects biochemical as well as molecular factors, are particularly important for determining individual recovery and long-term adaptations. The primary aim of the current study was to investigate the expression levels of small non-coding RNAs in response to HS and SS training in elite cyclists as potential biomarkers for individual optimal restitution time...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38530536/the-synergetic-effect-of-3d-printing-and-electrospinning-techniques-in-the-fabrication-of-bone-scaffolds
#15
REVIEW
Yongjie Qi, Hangying Lv, Qinghua Huang, Guangyong Pan
The primary goal of bone tissue engineering is to restore and rejuvenate bone defects by using a suitable three-dimensional scaffold, appropriate cells, and growth hormones. Various scaffolding methods are used to fabricate three-dimensional scaffolds, which provide the necessary environment for cell activity and bone formation. Multiple materials may be used to create scaffolds with hierarchical structures that are optimal for cell growth and specialization. This study examines a notion for creating an optimal framework for bone regeneration using a combination of the robocasting method and the electrospinning approach...
March 26, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38530161/subperiosteal-delivery-of-transforming-growth-factor-beta-1%C3%A2-and-human-growth-hormone-from-mineralized-pcl-films
#16
JOURNAL ARTICLE
Matthew B Parlato, Jae Sung Lee, David G Belair, Gianluca Fontana, Ellen Leiferman, Rewais Hanna, Connie Chamberlain, Erik A Ranheim, William L Murphy, Matthew A Halanski
The ability to locally deliver bioactive molecules to distinct regions of the skeleton may provide a novel means by which to improve fracture healing, treat neoplasms or infections, or modulate growth. In this study, we constructed single-sided mineral-coated poly-ε-caprolactone membranes capable of binding and releasing transforming growth factor beta 1 (TGF-β1) and human growth hormone (hGH). After demonstrating biological activity in vitro and characterization of their release, these thin bioabsorbable membranes were surgically implanted using an immature rabbit model...
March 26, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38529069/isolation-and-characterization-of-cholera-toxin-gene-positive-vibrio-cholerae-non-o1-non-o139-isolated-from-urinary-tract-infection-a-case-report
#17
Reem Aljindan, Reema Allahham, Rana Alghamdi, Ibrahim Alhabib, Samia AlNassri, Wala Alkhalifa, Asim Diab, Amer Alomar, Lamya Yamani, Nasreldin Elhadi
BACKGROUND: Urinary tract infection (UTI) caused by V. cholerae is rare and less common. V. cholerae is a Gram-negative bacterium motile using single polar flagellum and, originally, is a waterborne microbe found in aquatic and estuarine environments. Toxigenic V. cholerae is well-known as a causative agent of acute and excessive watery diarrhea after ingesting food and water contaminated with this bacterium. CASE PRESENTATION: A 27-year-old male patient presented to the emergency department on 17th July 2021 with burning micturition, normal vital signs, and no fever, vomiting, or diarrhea...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38524101/changes-in-feno-d-roms-and-bh-4-by-intravenous-l-arginine-in-children-and-its-putative-role-in-asthma-treatment
#18
JOURNAL ARTICLE
Naho Yamamoto, Saki Kasuga, Daijiro Kabata, Myu Ono, Sakura Ando, Taisuke Hashimoto, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki
PURPOSE: Pteridines are metabolites of tetrahydrobiopterin (BH4 ), being coenzymes for nitric oxide synthase (NOS). No study has clarified the relationship among pteridines and NOS, fractional exhaled nitric oxide (FeNO) generated by pteridines, and reactive oxygen species. In this study, we administered arginine, a precursor of NO, and confirmed changes in the levels of pteridines, FeNO, and reactive oxygen species and their relationship to clarify the pathogenesis of airway inflammation in which oxidative stress is involved, such as bronchial asthma...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38523384/local-control-and-toxicity-outcomes-following-consolidative-radiation-therapy-in-patients-with-high-risk-neuroblastoma-a-20-year-experience-at-a-single-center
#19
JOURNAL ARTICLE
Jeong Yun Jang, Jin-Hong Park, Yeon Joo Kim, Ho Joon Im, Kyung-Nam Koh, Hyery Kim, Sung Han Kang, Ha Un Kim, Seung Do Ahn
BACKGROUND: Intensive multimodal treatment can improve survival in patients with high-risk neuroblastoma, and consolidative radiation therapy has contributed to local control. We examined the clinical outcomes of patients who underwent consolidative radiation therapy at our institution. METHODS: We retrospectively reviewed the records of patients with high-risk neuroblastoma who underwent consolidative radiation therapy from March 2001 to March 2021 at Asan Medical Center...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38520613/validity-of-galactin-3-in-acromegaly-comparison-with-traditional-markers
#20
JOURNAL ARTICLE
Maryam Thaer Saadi, Noor Ulhuda G Mohammed, Baydaa Ahmed Abed, Layla Othman Farhan, Isam Noori Salman
BACKGROUND: Acromegaly occurs due to overproduction of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Galectin-3 (Gal-3) has recently emerged as a novel biomarker, related to IGF-1. This study aimed to assess Gal-3 in patients with acromegaly and compare its effectiveness with traditional biomarker tests. MATERIALS AND METHODS: A randomized case control study conducted in a single center included 50 acromegaly patients and 40 apparently healthy subjects (HS) serve as control group matched both age and BMI...
March 23, 2024: Irish Journal of Medical Science
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