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https://www.readbyqxmd.com/read/29157780/growth-hormone-gh-and-prolactin-responses-to-a-non-exercise-stress-test-in-athletes-with-overtraining-syndrome-results-from-the-endocrine-and-metabolic-responses-on-overtraining-syndrome-eros-eros-stress
#1
Flavio A Cadegiani, Claudio E Kater
OBJECTIVES: Overtraining syndrome (OTS) leads to worsened sports performance and fatigue. The pathophysiology of OTS has not been entirely elucidated, and there is a lack of accurate markers for its diagnosis. Changes in hormonal responses implicated in OTS were stimulated by exercise, which has limited their interpretation. Hence, we aimed to evaluate growth hormone (GH) and prolactin responses to a gold-standard and exercise-independent stimulation test, the insulin tolerance test (ITT)...
November 16, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29157111/hmga2-cooperates-with-either-p27-kip1-deficiency-or-cdk4-r24c-mutation-in-pituitary-tumorigenesis
#2
Monica Fedele, Orlando Paciello, Davide De Biase, Mario Monaco, Gennaro Chiappetta, Michela Vitiello, Antonio Barbieri, Domenica Rea, Antonio Luciano, Serenella Papparella, Claudio Arra, Alfredo Fusco
We have previously reported a critical role of HMGA proteins in pituitary tumorigenesis since either the Hmga1 or Hmga2 gene overexpression/activation induces the development of mixed growth hormone/prolactin cell pituitary adenomas by activating the E2F transcription factor 1, and then enhancing the G1/S transition of the cell cycle. Consistently, amplification and overexpression of the HMGA2 gene was found in human pituitary prolactinomas. Since impairment of the cell cycle control represents a feature of experimental and human pituitary adenomas, we have investigated the possible synergism between the alterations of other cell cycle regulators, such as p27 deficiency or Cdk4(R24C) mutation, with Hmga2 overexpression in pituitary tumorigenesis...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29155992/ihh-gene-mutations-causing-short-stature-with-non-specific-skeletal-abnormalities-and-response-to-growth-hormone-therapy
#3
Gabriela A Vasques, Mariana F A Funari, Frederico M Ferreira, Miriam Aza-Carmona, Lucia Sentchordi-Montané, Jimena Barraza-García, Antonio M Lerario, Guilherme L Yamamoto, Michel S Naslavsky, Yeda A O Duarte, Debora R Bertola, Karen E Heath, Alexander A L Jorge
Context: Genetic evaluation has been recognized as an important tool to elucidate the causes of growth disorders. Objective: To investigate the etiology of short stature and to determine the phenotype of patients with IHH mutations, including the response to growth hormone (rhGH) therapy. Patients and Methods: We studied 17 families with autosomal dominant short stature using whole exome sequencing and screened IHH defects in 290 patients with growth disorders...
November 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29155981/des-acyl-ghrelin-decreases-anxiety-like-behavior-in-male-mice
#4
Parinaz Mahbod, Eric P Smith, Maureen E Fitzgerald, Rachel L Morano, Benjamin A Packard, Sriparna Ghosal, Jessie R Scheimann, Diego Perez-Tilve, James P Herman, Jenny Tong
Ghrelin is a 28-amino acid polypeptide that regulates feeding, glucose metabolism and emotionality (stress, anxiety and depression). Plasma ghrelin circulates as desacyl ghrelin (DAG) or in an acylated form, acyl ghrelin (AG), through the actions of Ghrelin -O-Acyltransferase (GOAT), exhibiting low or high affinity, respectively, for the growth hormone secretagogue receptor (GHSR1a). We investigated the role of endogenous AG, DAG and GHSR1a signaling on anxiety and stress responses using ghrelin knockout (Ghr KO), GOAT KO, and Ghsr-stop-floxed (Ghsr null) mice...
November 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/29155347/postoperative-gamma-knife-radiosurgery-for-cavernous-sinus-invading-growth-hormone-secreting-pituitary-adenomas
#5
Eui Hyun Kim, Min Chul Oh, Jong Hee Chang, Ju Hyung Moon, Cheol Ryong Ku, Won-Seok Chang, Eun Jig Lee, Sun Ho Kim
OBJECTIVE: We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects. METHODS: Thirty patients who had remnant tumors only inside the CS after TSS and who consequently underwent GKS were included. They were followed for a median period of 47 months after GKS with regular hormonal and radiological examinations...
November 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155267/chronic-subcutaneous-infusion-of-neurosecretory-protein-gm-increases-body-mass-gain-in-chicks
#6
Kenshiro Shikano, Shusuke Taniuchi, Eiko Iwakoshi-Ukena, Megumi Furumitsu, George E Bentley, Lance J Kriegsfeld, Kazuyoshi Ukena
Recently we discovered a small hypothalamic protein in the chicken, named neurosecretory protein GL (NPGL), which is associated with body growth and energy metabolism in birds and rodents. Genome database analysis suggested that the NPGL gene has a paralogous gene in vertebrates, named neurosecretory protein GM (NPGM). However, the biological action of NPGM remains unclear. In this study, we investigated whether NPGM affects body growth in chicks. We found that subcutaneous infusion of NPGM for six days increased body mass gain in a dose-dependent manner...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29154935/ghrelin-alleviates-paclitaxel-induced-peripheral-neuropathy-by-reducing-oxidative-stress-and-enhancing-mitochondrial-anti-oxidant-functions-in-mice
#7
Nobuyuki Ishii, Hironobu Tsubouchi, Ayako Miura, Shigehisa Yanagi, Hiroaki Ueno, Kazutaka Shiomi, Masamitsu Nakazato
Paclitaxel is an effective chemotherapeutic agent, but has some treatment-limiting adverse effects that markedly decrease patients' quality of life. Peripheral neuropathy is one of these, and no treatment for it has been established yet. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is secreted from the stomach and has widespread effects on multiple systems. We investigated the pharmacological potential of ghrelin in preventing paclitaxel-induced peripheral neuropathy using wild-type mice, ghrelin-null mice, and growth hormone secretagogue receptor-null mice...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154485/epistatic-effects-between-pairs-of-the-growth-hormone-secretagogue-receptor-1a-growth-hormone-growth-hormone-receptor-non-smc-condensin-i-complex-subunit-g-and-stearoyl-coa-desaturase-genes-on-carcass-price-related-and-fatty-acid-composition-traits-in-japanese
#8
Masanori Komatsu, Kagetomo Nishino, Yuki Fujimori, Yasutoshi Haga, Nagako Iwama, Aisaku Arakawa, Yoshito Aihara, Hisato Takeda, Hideaki Takahashi
Growth hormone secretagogue receptor 1a (GHSR1a), growth hormone (GH), growth hormone receptor (GHR), non-SMC condensin I complex, subunit G (NCAPG) and stearoyl-CoA desaturase (SCD), are known to play important roles in growth and lipid metabolisms. Single and epistatic effects of the five genes on carcass, price-related and fatty acid (FA) composition traits were analyzed in a commercial Japanese Black cattle population of Ibaraki Prefecture. A total of 650 steers and 116 heifers for carcass and price-related traits, and 158 steers for FA composition traits were used in this study...
November 20, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29154428/muscle-wasting-and-sarcopenia-in-heart-failure-and-beyond-update-2017
#9
REVIEW
Jochen Springer, Joshua-I Springer, Stefan D Anker
Sarcopenia (loss of muscle mass and muscle function) is a strong predictor of frailty, disability and mortality in older persons and may also occur in obese subjects. The prevalence of sarcopenia is increased in patients suffering from chronic heart failure. However, there are currently few therapy options. The main intervention is resistance exercise, either alone or in combination with nutritional support, which seems to enhance the beneficial effects of training. Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153839/asymmetry-between-activation-and-deactivation-during-a-transcriptional-pulse
#10
Lee S S Dunham, Hiroshi Momiji, Claire V Harper, Polly J Downton, Kirsty Hey, Anne McNamara, Karen Featherstone, David G Spiller, David A Rand, Bärbel Finkenstädt, Michael R H White, Julian R E Davis
Transcription in eukaryotic cells occurs in gene-specific bursts or pulses of activity. Recent studies identified a spectrum of transcriptionally active "on-states," interspersed with periods of inactivity, but these "off-states" and the process of transcriptional deactivation are poorly understood. To examine what occurs during deactivation, we investigate the dynamics of switching between variable rates. We measured live single-cell expression of luciferase reporters from human growth hormone or human prolactin promoters in a pituitary cell line...
November 13, 2017: Cell Systems
https://www.readbyqxmd.com/read/29153669/maternal-serum-igf-1-igfbp-1-and-3-and-placental-growth-hormone-at-20weeks-gestation-in-pregnancies-complicated-by-preeclampsia
#11
Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). STUDY DESIGN: In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153350/management-of-mobilization-failure-in-2017
#12
REVIEW
Sinem Namdaroglu, Serdal Korkmaz, Fevzi Altuntas
In contemporary clinical practice, almost all allogeneic transplantations and autologous transplantations now capitalize on peripheral blood stem cells (PBSCs) as opposed to bone marrow (BM) for the source of stem cells. In this context, granulocyte colony-stimulating factor (G-CSF) plays a pivotal role as the most frequently applied frontline agent for stem cell mobilization. For patients classified as high-risk, chemotherapy based mobilization regimens can be preferred as a first choice and it is notable that this also used for remobilization...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153202/growth-hormone-as-biomarker-in-heart-failure
#13
REVIEW
Alberto M Marra, Emanuele Bobbio, Roberta D'Assante, Andrea Salzano, Michele Arcopinto, Eduardo Bossone, Antonio Cittadini
The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29153168/a-100-year-review-mammary-development-and-lactation
#14
R Michael Akers
What is old is new again-and with respect to the study of the mammary development and function in dairy animals, the expression resonates. Many of the mammary and milk production questions raised in the early years of the Journal of Dairy Science apply today. To be sure, scientists have filled in many details regarding, for example, identification of hormones and growth factors important in the control of mammary growth, the onset of copious milk production at calving, and maintenance of lactation. Early years focused on identification and subsequent availability of classic mammogenic, lactogenic, and galactopoietic hormones (e...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152903/reproductive-endocrine-phenotypes-relating-to-chd7-mutations-in-humans
#15
REVIEW
Ravikumar Balasubramanian, William F Crowley
Mutations in the gene CHD7 cause CHARGE syndrome, a rare multi-organ syndromic disorder. Gonadal defects are common in individuals with CHARGE syndrome (seen in ∼60-80% of cases) and represent the letter "G" in the CHARGE syndrome acronym. The gonadal defect in CHARGE syndrome results from congenital deficiency of the hypothalamic hormone Gonadotropin-releasing hormone (GnRH), which manifests clinically as pubertal failure and infertility, and biochemically as hypogonadotropic hypogonadism (low sex steroid hormone levels with inappropriately normal or low gonadotropin levels)...
November 20, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29152592/revisiting-the-igf-1r-as-a-breast-cancer-target
#16
Roudy Chiminch Ekyalongo, Douglas Yee
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed. Unfortunately, monoclonal antibodies and tyrosine kinase inhibitors targeting insulin-like growth factor-1 receptor failed in phase III breast clinical trials for several reasons. First, insulin-like growth factor-1 receptor antibody therapy resulted in hyperglycemia and metabolic syndrome most likely due to disruption of insulin-like growth factor-1 homeostasis and subsequent growth hormone elevation...
2017: NPJ Precis Oncol
https://www.readbyqxmd.com/read/29152430/a-dosimetric-comparison-of-intensity-modulated-proton-therapy-volumetric-modulated-arc-therapy-and-4%C3%AF-non-coplanar-intensity-modulated-radiation-therapy-for-a-patient-with-parameningeal-rhabdomyosarcoma
#17
Tiffany W Chen, Julian Sison, Becky Lee, Arthur J Olch, Andrew Chang, Annelise Giebeler, Kenneth Wong
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and manifests as two major histological subtypes: embryonal and alveolar. The five-year local failure rate for RMS at parameningeal sites (middle ear, mastoid region, nasal cavity, etc.) is around 17% despite multiple Intergroup Rhabdomyosarcoma Study Group (IRS) trials conducted to determine the optimal radiation treatment regimen. This case report explores the use of intensity-modulated proton therapy (IMPT) for a 10-year-old child who presented with left eye irritation, facial pain, and headaches and was found to have an alveolar parameningeal rhabdomyosarcoma...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29152285/mexican-case-report-of-a-never-treated-laron-syndrome-patient-evolving-to-metabolic-syndrome-type-2-diabetes-and-stroke
#18
Inma Castilla-Cortazar, Giovana Femat-Roldán, Joel Rodríguez-Rivera, Gabriel A Aguirre, Mariano García-Magariño, Irene Martín-Estal, Luis Espinosa, Carlos Díaz-Olachea
Glucose and lipid profile together with blood pressure should always be considered for low sera-IGF-1 patients. Even when adulthood is reached, IGF-1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29151078/therapeutic-effect-of-exogenous-ghrelin-in-the-healing-of-gingival-ulcers-is-mediated-by-the-release-of-endogenous-growth-hormone-and-insulin-like-growth-factor-1
#19
J Cieszkowski, Z Warzecha, P Ceranowicz, D Ceranowicz, B Kusnierz-Cabala, M Pedziwiatr, M Dembinski, T Ambrozy, T Kaczmarzyk, M Pihut, M Wieckiewicz, R Olszanecki, A Dembinski
Ghrelin, an acylated 28-amino acid polypeptide, was primary isolated from the stomach, and the stomach is a main source of circulating ghrelin. Ghrelin strongly and dose-dependently stimulates release of growth hormone from the anterior pituitary, as well as increases food intake and fat deposition. Previous studies showed that ghrelin exhibits protective and therapeutic effect in different parts of the gastrointestinal system, including the oral cavity. The aim of present study was to examine the role of growth hormone and insulin-like growth factor-1 (IGF-1) in the healing of gingival ulcers...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#20
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
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