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https://www.readbyqxmd.com/read/29165838/discordance-of-pediatric-morphea-treatment-by-pediatric-dermatologists
#1
Megha M Tollefson, Yvonne E Chiu, Heather A Brandling-Bennett, Elena Pope
BACKGROUND/OBJECTIVES: Studies describing treatment efficacy in pediatric morphea are lacking. Subspecialists have reached no consensus on how to optimally treat pediatric morphea. The objective of the current study was to describe the most common treatment practices of pediatric dermatologists worldwide who care for children with morphea. METHODS: A survey regarding topical treatment practices of pediatric morphea, with representative case-based scenarios, was distributed to pediatric dermatologists and results were tallied...
November 22, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29164309/pathologic-diagnosis-and-genetic-analysis-of-a-lung-tumor-needle-biopsy-specimen-obtained-immediately-after-radiofrequency-ablation
#2
Takaaki Hasegawa, Chiaki Kondo, Yozo Sato, Yoshitaka Inaba, Hidekazu Yamaura, Mina Kato, Shinichi Murata, Yui Onoda, Hiroaki Kuroda, Yukinori Sakao, Yasushi Yatabe
PURPOSE: To evaluate the possibility of pathologic diagnosis and genetic analysis of percutaneous core-needle biopsy (CNB) lung tumor specimens obtained immediately after radiofrequency ablation (RFA). MATERIALS AND METHODS: Patients who underwent CNB of lung tumors immediately after RFA from May 2013 to May 2016 were analyzed. There were 19 patients (8 men and 11 women; median age, 69 years; range, 52-88 years) and 19 lung tumors measuring 0.5-2.6 cm (median, 1...
November 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29162061/medical-student-attitudes-and-educational-interventions-to-prevent-neurophobia-a-longitudinal-study
#3
Lisa Shiels, Pratish Majmundar, Aleksander Zywot, John Sobotka, Christine S M Lau, Tuula O Jalonen
BACKGROUND: With an aging American population, the burden of neurologic disease is intensifying and the decline in neurology residents and practicing neurologists is leaving these patients helpless and unable to find care. 'Neurophobia', a chronic illness that begins early in medical school, has been identified as a cause for the low number of neurology residents. METHODS: A longitudinal study surveyed medical students at the beginning of their first year (M1) and then again at the beginning of their second year (M2)...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29158645/evaluation-of-functional-outcome-of-pilon-fractures-managed-with-limited-internal-fixation-and-external-fixation-a-prospective-clinical-study
#4
Umesh Kumar Meena, Mahesh Chand Bansal, Prateek Behera, Rahul Upadhyay, Gyan Chand Gothwal
Introduction: The management of pilon fractures is controversial primarily due to the high rate of complications irrespective of the mode of treatment. Limited internal fixation with external fixation is associated with minimal soft tissue handling. This may reduce the chances of wound dehiscence and infection. This study was designed to evaluate the functional and clinical outcomes in patients treated with limited internal fixation combined with external fixation in pilon fractures. Material and methods: This study was conducted as a prospective clinical study on 56 skeletally mature patients with closed fractures with poor skin condition, and with open grade 1 and grade 2 distal tibial intra-articular fractures...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29155819/determinants-of-site-of-tuberculosis-disease-an-analysis-of-european-surveillance-data-from-2003-to-2014
#5
Giovanni Sotgiu, Dennis Falzon, Vahur Hollo, Csaba Ködmön, Nicolas Lefebvre, Andrei Dadu, Marieke van der Werf
BACKGROUND: We explored host-related factors associated with the site of tuberculosis (TB) disease using variables routinely collected by the 31 EU/EEA countries for national surveillance. METHODS: Logistic regression models were fitted to case-based surveillance data reported to the European Centre for Disease Prevention and Control for TB cases notified from 2003 to 2014. Missing data on HIV infection and on susceptibility to isoniazid and rifampicin for many patients precluded the inclusion of these variables in the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29153352/-choosing-wisely-in-medical-education
#6
Milena Goldmann, Angelina-Charline Middeke, Nikolai Schuelper, Terese Dehl, Tobias Raupach
Choosing Wisely recommendations address situations where physicians will have to make decisions about further diagnostic and therapeutic steps. Undergraduate medical education needs to equip students with the foundations on which clinical reasoning skills can be acquired and fostered throughout their clinical career. Teaching these skills usually involves patients (e.g., bedside teaching, electives, clinical attachments) but it can also be delivered in the format of formalised small-group, case-based learning...
November 15, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29147954/a-fully-automatic-end-to-end-method-for-content-based-image-retrieval-of-ct-scans-with-similar-liver-lesion-annotations
#7
A B Spanier, N Caplan, J Sosna, B Acar, L Joskowicz
PURPOSE: The goal of medical content-based image retrieval (M-CBIR) is to assist radiologists in the decision-making process by retrieving medical cases similar to a given image. One of the key interests of radiologists is lesions and their annotations, since the patient treatment depends on the lesion diagnosis. Therefore, a key feature of M-CBIR systems is the retrieval of scans with the most similar lesion annotations. To be of value, M-CBIR systems should be fully automatic to handle large case databases...
November 16, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29147646/creation-and-pilot-testing-of-cases-for-case-based-learning-a-pedagogical-approach-for-pathology-cancer-diagnosis
#8
Shahin Sayed, Susan C Lester, Michael Wilson, Daniel Berney, Ricard Masia, Zahir Moloo, Jennifer Stall, Alexia Eslan, Stephanie Ayers, Angela Mutuku, Jeannette Guarner
Background: Case-based learning (CBL) is an established pedagogical active learning method used in various disciplines and defined based on the field of study and type of case. The utility of CBL for teaching specific aspects of cancer diagnosis to practising pathologists has not been previously studied in sub-Saharan Africa. Objectives: We aimed to pilot test standardised cancer cases on a group of practising pathologists in sub-Saharan Africa to evaluate case content, clarity of questions and delivery of content...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/29147470/retrospective-analysis-of-inferior-vena-cava-collapsibility-with-point-of-care-ultrasound-and-urine-sodium-and-fena-in-patients-with-early-stage-acute-kidney-injury
#9
Faizan Babar, Gurkeerat Singh, Mustafa Noor, Bruce Sabath
Early stage acute kidney injury (AKI) is an independent risk factor for an increase in mortality. Accurate assessment of volume status is a major challenge during the early stages of acute renal injury. Determining volume status based on the history and physical exam lacks accuracy. Urine sodium and free excretion of sodium (FENa) provide objective evidence of intravascular volume status when interpreted carefully and is helpful to delineate prerenal from intrinsic renal failure. In recent years point of care ultrasound has been used to assess volume status...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146398/improving-logistic-efficiency-of-weee-collection-through-dynamic-scheduling-using-simulation-modeling
#10
Valerio Elia, Maria Grazia Gnoni, Fabiana Tornese
The complexity of collection systems for Waste from Electric and Electronic Equipment (WEEE) in the EU is increasing, due to the latest directive that sets new collection targets and modes. The high variability and the uncertainty of reverse flows require innovative logistic approaches. One recent option for increasing efficiency and responsiveness in waste collection services, boosted by new technological solutions for waste level monitoring, is to adopt a dynamic collection scheme, where the collection frequency is not established a priori (based on a fixed plan), but it is based on the actual filling levels of waste bins...
November 13, 2017: Waste Management
https://www.readbyqxmd.com/read/29146291/development-of-ms-binding-assays-targeting-the-binding-site-of-mb327-at-the-nicotinic-acetylcholine-receptor
#11
S Sichler, G Höfner, S Rappenglück, T Wein, K V Niessen, T Seeger, F Worek, H Thiermann, F F Paintner, K T Wanner
The bispyridinium compound MB327 has been shown previously to have a positive pharmacological effect against poisoning with organophosphorous compounds (OPCs). The mechanism by which it exerts its therapeutic effect seems to be directly mediated by the nicotinic acetylcholine receptor (nAChR). In the present study, the development of mass spectrometry based binding assays (MS Binding Assays) for characterization of the binding site of MB327 at the nAChR from Torpedo californica is described. MS Binding Assays follow the principle of radioligand binding assays, but do not, in contrast to the latter, require a radiolabeled reporter ligand, as the readout is in this case based on mass spectrometric detection...
November 13, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29143076/magnetic-resonance-elastography-beyond-liver-fibrosis-a-case-based-pictorial-review
#12
REVIEW
Sudhakar K Venkatesh, Michael L Wells, Frank H Miller, Kartik S Jhaveri, Alvin C Silva, Bachir Taouli, Richard L Ehman
Magnetic resonance elastography (MRE) has been introduced for clinical evaluation of liver fibrosis for nearly a decade. MRE has proven to be a robust and accurate technique for diagnosis and staging of liver fibrosis. As clinical experience with MRE grows, the possible role in evaluation of other diffuse and focal disorders of liver is emerging. Stiffness maps provide an opportunity to evaluate mechanical properties within a large volume of liver tissue. This enables appreciation of spatial heterogeneity of stiffness...
November 15, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29142475/predictive-factors-associated-with-carcinoid-syndrome-in-patients-with-gastrointestinal-neuroendocrine-tumors
#13
Beilei Cai, Michael S Broder, Eunice Chang, Tingjian Yan, David C Metz
AIM: To discover unknown factors associated with carcinoid syndrome (CS) with the goal of earlier diagnosis of CS. METHODS: In this retrospective case-control study using United States administrative claims, patients (≥ 18 years) newly-diagnosed with gastrointestinal neuroendocrine tumors (GI NETs) without CS (controls) were exactly matched to patients with CS (cases) based on NET diagnosis date at a 3-to-1 ratio. Study index date was first CS diagnosis (controls: same distance from NET diagnosis as cases)...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29136628/incidence-of-multiple-sclerosis-in-germany-a-cohort-study-applying-different-case-definitions-based-on-claims-data
#14
Niklas Schmedt, Laura Khil, Klaus Berger, Oliver Riedel
BACKGROUND: Data on the incidence of multiple sclerosis (MS) on the national level is scarce. We aimed to estimate the incidence of MS in Germany and to compare different MS case definitions based on claims data. METHODS: We conducted a cohort study with the German Pharmacoepidemiological Research Database in 2012 and calculated age- and gender-standardized incidence rates (sIRs) for 3 case definitions. In addition, the effect of stepwise reduction of the look-back period without MS diagnosis on the incidence rate was evaluated...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29134349/the-impact-of-mri-sequence-on-tumour-staging-and-gross-tumour-volume-delineation-in-squamous-cell-carcinoma-of-the-anal-canal
#15
Davide Prezzi, Ramin Mandegaran, Sofia Gourtsoyianni, Katarzyna Owczarczyk, Andrew Gaya, Robert Glynne-Jones, Vicky Goh
OBJECTIVES: To compare maximum tumour diameter (MTD) and gross tumour volume (GTV) measurements between T2-weighted (T2-w) and diffusion-weighted (DWI) MRI in squamous cell carcinoma of the anal canal (SCCA) and assess sequence impact on tumour (T) staging. Second, to evaluate interobserver agreement and reader delineation confidence. METHODS: The staging MRI scans of 45 SCCA patients (25 females) were assessed retrospectively by two independent radiologists (0 and 5 years' experience of anal cancer MRI)...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29134124/the-design-and-implementation-of-the-software-tracking-cervical-and-lumbar-vertebrae-in-spinal-fluoroscopy-images
#16
Behrouz Alizadeh Savareh, Yousef Sadat, Azadeh Bashiri, Mehraban Shahi, Nasrin Davaridolatabadi
Aim: Manual analysis of neck kinematics is usually associated with measurement errors and it requires the use of software capabilities. Considering laboratory usage, software has been developed to solve the associated problems. Materials & methods: Fluoroscopic images taken from 78 women were used to design and evaluate the performance of the software. The software was implemented using C# language, according to the case-based reasoning technique. Results: The viewpoints of experts suggest accuracy of the software in tracking and calculations, which meets their information requirements...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29131704/impact-of-team-composition-on-student-perceptions-of-interprofessional-teamwork-a-6-year-cohort-study
#17
Chad Lairamore, Duston Morris, Rachel Schichtl, Lorrie George-Paschal, Heather Martens, Alexandros Maragakis, Mary Garnica, Barbara Jones, Myra Grantham, Adam Bruenger
Interprofessional education (IPE) provides students with opportunities to learn about the roles and responsibilities of other professions and develop communication and teamwork skills. As different health professions have recognised the importance of IPE, the number of disciplines participating in IPE events is increasing. Consequently, it is important to examine the effect group structure has on the learning environment and student knowledge acquisition during IPE events. The purpose of this study was to determine the effect of group composition on student perceptions of interprofessional teamwork and collaboration when participating in a case-based IPE forum...
November 13, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29131399/cholangitis-and-cholangiohepatitis-in-dogs-a-descriptive-study-of-54-cases-based-on-histopathologic-diagnosis-2004-2014
#18
J L Harrison, B J Turek, D C Brown, C Bradley, J Callahan Clark
BACKGROUND: Cholangitis in dogs appears to be more common than previously thought, but understanding of the disease remains incomplete. OBJECTIVE: To describe a population of dogs with cholangitis or cholangiohepatitis. ANIMALS: Fifty-four client-owned dogs with cholangitis or cholangiohepatitis. METHODS: Medical records of dogs with cholangitis or cholangiohepatitis confirmed by histopathology between January 2004 and December 2014 were identified using a computer-based search and retrospectively reviewed...
November 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29129176/composite-reliability-of-workplace-based-assessment-of-international-medical-graduates
#19
Balakrishnan Kichu R Nair, Joyce Mw Moonen-van Loon, Mulavana Parvathy, Brian C Jolly, Cees Pm van der Vleuten
OBJECTIVE: The fitness to practise of international medical graduates (IMGs) is usually evaluated with standardised assessment tests. The performance rather than the competency of practising doctors should, however, be assessed, for which reason workplace-based assessment (WBA) has gained increasing attention. Our aim was to assess the composite reliability of WBA instruments for assessing IMGs. DESIGN AND SETTING: Between June 2010 and April 2015, 142 IMGs were assessed by 99 calibrated assessors; each was assessed in the workplace over 6 months...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29129005/chronic-overdrainage-syndrome-pathophysiological-insights-based-on-icp-analysis-a-case-based-review
#20
REVIEW
Laura V Sainz, Konstantin Hockel, Martin U Schuhmann
INTRODUCTION: Chronic overdrainage affects shunted patients producing a variety of symptoms that may be misdiagnosed. The best known symptoms are so-called shunt-related headaches. There is mounting evidence that changes in cerebrospinal venous system dynamics are a key factor to the pathophysiology of chronic overdrainage syndrome. CLINICAL PRESENTATION: We report the case of a 29-year-old woman with a shunt since the postnatal period suffering from chronic but the most severe intermittent headache attacks, despite an open shunt and with unchanged ventricular width during attacks...
November 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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