Eric Song, Aakash Nagarapu, Johan van Nispen, Austin Armstrong, Chandrashekhara Manithody, Vidul Murali, Marcus Voigt, Ashish Samaddar, Chelsea Hutchinson, Sonali Jain, Jeremy Roenker, Joseph Krebs, Ajay K Jain
BACKGROUND: Parenteral nutrition (PN) remains a critical therapeutic option in patients who cannot tolerate enteral feeding. However, although lifesaving, PN is associated with significant side effects, including liver injury, the etiology of which is multifactorial. Carbamazepine (CBZ), an antiepileptic medication, is known to modulate hepatic fibrosis and hepatocellular injury in a variety of liver diseases. We hypothesized that CBZ could prevent PN-associated liver disease (PNALD), which we tested by using our novel ambulatory PN piglet model...
August 2022: JPEN. Journal of Parenteral and Enteral Nutrition