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https://www.readbyqxmd.com/read/27933715/efficacy-of-self-monitoring-of-blood-glucose-versus-retrospective-continuous-glucose-monitoring-in-improving-glycaemic-control-in-diabetic-kidney-disease-patients
#1
Ester Chai Kheng Yeoh, Boon Khim Lim, Sharon Fun, Julia Tong, Lee Ying Yeoh, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim
AIMS: Patients with diabetic kidney disease (DKD) on anti-diabetic agents, are at greater risk of glycemic variations, both hypoglycemia and hyperglycemia. We aimed to compare glycemic control (using HbA1c) and hypoglycemia incidence in patients with Stage 3 DKD (eGFR 30-60 ml/min/1.73 m(2) ), receiving retrospective CGM-guided anti-diabetic therapy versus self-monitoring of blood glucose (SMBG) over 3 months. METHODS: Thirty patients with HbA1c > 8% were randomized to 6-day retrospective CGM or SMBG...
December 9, 2016: Nephrology
https://www.readbyqxmd.com/read/27933185/circulating-serpinb1-levels-and-clinical-features-in-patients-with-type-2-diabetes
#2
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
OBJECTIVE: The main purpose of this study was to investigate the association of serum SerpinB1 levels and various parameters in patients with type 2 diabetes. The effect of canagliflozin (a sodium glucose cotransporter 2 (SGLT2) inhibitor), which can decrease circulating insulin levels, on serum SerpinB1 levels was also investigated. A recent study suggests that the serum levels of SerpinB1, also known as monocyte neutrophil elastase inhibitor, increase with insulin resistance, may have a protective effect for pancreatic β cells, and may decrease insulin resistance...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27932304/vitamin-d-and-type-2-diabetes
#3
REVIEW
Paul Lips, Marelise Eekhoff, Natasja Vzn Schoor, Mirjam Oosterwerff, Renate de Jongh, Yvonne Krul-Poel, Suat Simsek
Vitamin D deficiency is associated with a decreased insulin release, insulin resistance and type 2 diabetes in experimental and epidemiological studies. Animal studies show that 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) stimulates the pancreatic β-cell to secrete insulin. The relationship between vitamin D deficiency and insulin resistance could develop through inflammation, as vitamin D deficiency is associated with increased inflammatory markers. In addition, genetic polymorphisms of vitamin D -related genes may predispose to impaired glycemic control and type 2 diabetes...
December 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27932047/disturbances-of-glucose-metabolism-associated-with-the-use-of-psychotropic-drugs-a-post-mortem-evaluation
#4
Cristian Palmiere, Marc Augsburger, Vincent Varlet
Treatment with atypical antipsychotic agents and tetracyclic antidepressants has been associated with impaired glycemic control. Reported complications have included new-onset diabetes mellitus, life-threatening diabetic ketoacidosis and, rarely, death. The study presented herein focuses on biochemical investigations of glucose metabolism in a series of medico-legal cases that revealed the presence of atypical antipsychotic agents (clozapine, olanzapine, quetiapine and risperidone) or mirtazapine at toxicology...
December 5, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27931015/the-association-of-vitamin-d-status-and-vitamin-d-replacement-therapy-to-glycemic-control-serum-uric-acid-levels-and-microalbuminuria-among-patients-with-type-2-diabetes-with-chronic-kidney-disease
#5
Savas Sipahi, Seyyid Bilal Acikgoz, Ahmet Bilal Genc, Mehmet Yildirim, Yalcin Solak, Ali Tamer
No abstract text is available yet for this article.
December 6, 2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/27930583/diabetes-mellitus-and-prognosis-in-women-with-breast-cancer-a-systematic-review-and-meta-analysis
#6
Xiao-Bo Zhao, Guo-Sheng Ren
BACKGROUND: Diabetes mellitus is associated with an increased risk of breast cancer, but studies of the effects of diabetes on the prognosis of women with breast cancer have yielded inconsistent findings. The present meta-analysis aimed to investigate the impact of preexisting diabetes on the prognosis in terms of overall survival (OS), disease-free survival (DFS), and relapse-free period (RFP) in women with breast cancer. METHODS: We searched the Embase and PubMed databases until June 2016 for cohort or case-control studies assessing the impact of diabetes on the prognosis of women with breast cancer...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928867/reduction-of-medication-errors-related-to-sliding-scale-insulin-by-the-introduction-of-a-standardized-order-sheet
#7
Saki Harada, Akio Suzuki, Shohei Nishida, Ryo Kobayashi, Sayuri Tamai, Keisuke Kumada, Nobuo Murakami, Yoshinori Itoh
Insulin is frequently used for glycemic control. Medication errors related to insulin are a common problem for medical institutions. Here, we prepared a standardized sliding scale insulin (SSI) order sheet and assessed the effect of its introduction. Observations before and after the introduction of the standardized SSI template were conducted at Gifu University Hospital. The incidence of medication errors, hyperglycemia, and hypoglycemia related to SSI were obtained from the electronic medical records. The introduction of the standardized SSI order sheet significantly reduced the incidence of medication errors related to SSI compared with that prior to its introduction (12/165 [7...
December 7, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27928145/glycated-hemoglobin-and-risk-of-sternal-wound-infection-after-isolated-coronary-surgery
#8
Giuseppe Gatti, Andrea Perrotti, Daniel Reichart, Luca Maschietto, Francesco Onorati, Sidney Chocron, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Giuseppe Santarpino, Theodor Fischlein, Aniello Pappalardo, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Antonino S Rubino, Marisa De Feo, Francesco Santini, Francesco Nicolini, Riccardo Gherli, Giovanni Mariscalco, Tuomas Tauriainen, Eeva-Maija Kinnunen, Vito G Ruggieri, Matteo Saccocci, Fausto Biancari
BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0...
December 8, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27927976/metabolic-profiling-reveals-differences-in-plasma-concentrations-of-arabinose-and-xylose-after-consumption-of-fiber-rich-pasta-and-wheat-bread-with-differential-rates-of-systemic-appearance-of-exogenous-glucose-in-healthy-men
#9
Andre J Pantophlet, Suzan Wopereis, Coby Eelderink, Roel J Vonk, Johanna H Stroeve, Sabina Bijlsma, Leo van Stee, Ivana Bobeldijk, Marion G Priebe
BACKGROUND: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual-isotope technique, which was in accordance with a lower insulin and glucose-dependent insulinotropic polypeptide response. OBJECTIVE: To gain more insight into the acute metabolic consequences of the consumption of products resulting in differential glucose kinetics, postprandial metabolic profiles were determined...
December 7, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27927966/tolerogenic-dendritic-cells-from-poorly-compensated-type-1-diabetes-patients-have-decreased-ability-to-induce-stable-antigen-specific-t-cell-hyporesponsiveness-and-generation-of-suppressive-regulatory-t-cells
#10
Klára Dáňová, Anna Grohová, Pavla Strnadová, David P Funda, Zdeněk Šumník, Jan Lebl, Ondřej Cinek, Štěpánka Průhová, Stanislava Koloušková, Barbora Obermannová, Lenka Petruželková, Anna Šedivá, Petra Fundová, Karsten Buschard, Radek Špíšek, Lenka Palová-Jelínková
Tolerogenic dendritic cells (tolDCs) may offer an interesting intervention strategy to re-establish Ag-specific tolerance in autoimmune diseases, including type 1 diabetes (T1D). T1D results from selective destruction of insulin-producing β cells leading to hyperglycemia that, in turn, specifically affects a patient's immune system. In this study, we prepared monocyte-derived tolDCs modulated by dexamethasone and vitamin D2 from 31 T1D patients with optimal glycemic control and 60 T1D patients with suboptimal glycemic control and assessed their tolerogenic properties in correlation with metabolic state of patients...
December 7, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27927601/probiotic-supplementation-in-diabetic-hemodialysis-patients-has-beneficial-metabolic-effects
#11
Alireza Soleimani, Malihe Zarrati Mojarrad, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Ramezani, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Ahmad Esmaillzadeh, Zatollah Asemi
This study determined the effects of probiotic supplementation on glycemic control, lipid concentrations, biomarkers of inflammation and oxidative stress in 60 diabetic patients on hemodialysis in a parallel randomized double-blind placebo-controlled clinical trial. Participants were initially matched based on sex, duration of dialysis and diabetes, body mass index and age. Subsequently, they were randomly divided into two groups to take either a capsule containing the probiotics Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum or placebo for 12 weeks...
December 4, 2016: Kidney International
https://www.readbyqxmd.com/read/27926892/do-mobile-phone-applications-improve-glycemic-control-hba1c-in-the-self-management-of-diabetes-a-systematic-review-meta-analysis-and-grade-of-14-randomized-trials
#12
REVIEW
Can Hou, Ben Carter, Jonathan Hewitt, Trevor Francisa, Sharon Mayor
OBJECTIVE: To investigate the effect of mobile phone applications (apps) on glycemic control (HbA1c) in the self-management of diabetes. RESEARCH DESIGN AND METHODS: Relevant studies that were published between 1 January 1996 and 1 June 2015 were searched from five databases: Medline, CINAHL, Cochrane Library, Web of Science, and Embase. Randomized controlled trials that evaluated diabetes apps were included. We conducted a systematic review with meta-analysis and GRADE (Grading of Recommendations Assessment, Development and Evaluation) of the evidence...
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27924636/safety-and-tolerability-of-glucagon-like-peptide-1-receptor-agonists-unresolved-and-emerging-issues
#13
Denis Raccah
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a mainstay of treatment options for Type 2 diabetes. They contribute to lowering blood glucose levels, generally have a favorable tolerability profile, and can be used alone or in combination with other antidiabetic agents. Based on the duration of their effects, GLP-1 RAs can be divided into two classes: short-acting and long-acting. Differences exist between these sub-classes, and between each drug, in terms of pharmacokinetic and pharmacodynamic profiles...
December 7, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27921432/-composition-of-macronutrients-in-the-diabetic-diet
#14
Zdeněk Rušavý, Michal Žourek
The diabetic diet is one of the pillars of diabetes treatment. The rapid development of knowledge relating to the treatment of diabetes also includes diet. The paper focuses on the importance of a diet in the treatment of type 2 diabetes and prevention of atherosclerosis. Its main goal is to assess the impact of a composition of macronutrients on individuals with type 2 diabetes. The paper is divided into several parts, each of which ends with a conclusion. The first part examines weight reduction. The diet aimed at a weight loss is effective, it can effectively prevent diabetes, it leads to improvements in glucose control and reduction of the risk factors for atherosclerosis, however it will not impact on cardiovascular morbidity and mortality until after more than 20 years...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921431/-short-term-and-long-term-glycemic-variability-and-its-relationship-to-microvascular-complications-of-diabetes
#15
Martin Prázný, Jan Škrha, Jan Šoupal, Jan Škrha Jr
Vascular complications of diabetes result from long lasting unsatisfactory glycemic control. We usually assess glycemic control based on the value of glycated hemoglobin HbA1c. The glycated hemoglobin test, however, says nothing about short-term glycemic fluctuations. Recently, continuous monitoring of glycemia has enabled us an in-depth assessment of changes in glucose concentrations, called glycemic variability. In connection with the research into short-term glycemic variability, also the study of long-term fluctuations in glycemic control based on HbA1c variability has now intensified...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921430/-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#16
Andrea Plíhalová, Kateřina Westlake, Jan Polák
Obstructive sleep apnoea syndrome (OSA) is a disease very frequently occurring in people with type 2 diabetes, that significantly increases cardiovascular morbidity and mortality. In a number of studies, OSA has been identified as an independent risk factor for the development of insulin resistance, glucose intolerance and type 2 diabetes mellitus. Disorders of glucose homeostasis in patients with OSA are probably mediated by chronic intermittent hypoxia and/or sleep fragmentation through activation of the sympathetic nervous system, the hypothalamic-pituitary-adrenal stress axis, pro-inflammatory paths or oxidative stress...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#17
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921048/surgical-treatment-of-metabolic-syndrome
#18
REVIEW
Norbert Runkel, Rainer Brydniak
BACKGROUND: Bariatric surgery is gastrointestinal surgery for weight control, and metabolic surgery refers to the use of surgery to primarily and purposely treat type 2 diabetes mellitus (T2DM)/metabolic syndrome mellitus. METHODS: The most recent literature was reviewed for surgery and T2DM in a non-systematic fashion. RESULTS: Roux-Y gastric bypass, biliopancreatic diversion with duodenal switch, and sleeve gastrectomy (SG) are the dominant procedures today...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27918976/randomized-controlled-trial-of-a-family-oriented-self-management-program-to-improve-self-efficacy-glycemic-control-and-quality-of-life-among-thai-individuals-with-type-2-diabetes
#19
Nutchanath Wichit, George Mnatzaganian, Mary Courtney, Paula Schulz, Maree Johnson
AIMS: We evaluated a theoretically-derived family-oriented intervention aimed to improve self-efficacy, self-management, glycemic control and quality of life in individuals living with Type 2 diabetes in Thailand. METHODS: In a single-blinded randomized controlled trial, 140 volunteer individuals with Type 2 diabetes, recruited from a diabetes clinic in rural Thailand, were randomly allocated to intervention and control arms. Those in the intervention arm received routine care plus a family-oriented program that included education classes, group discussions, a home visit, and a telephone follow-up while the control arm only received routine care...
November 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27918955/defective-production-of-interleukin-1-beta-in-patients-with-type-2-diabetes-mellitus-restoration-by-proper-glycemic-control
#20
Foteini Kousathana, Marianna Georgitsi, Vaia Lambadiari, Evangelos J Giamarellos-Bourboulis, George Dimitriadis, Maria Mouktaroudi
The underlying immune defect of susceptibility in diabetes mellitus type 2 to infections remains unknown. The qualitative changes in cytokine biosynthesis by circulating mononuclear cells (PBMCs) and its modulation by glycemic control were investigated. PBMCs were isolated from 39 patients and 25 controls. They were stimulated with purified ligands and heat-killed bacteria in the absence/presence of glucose and NLPR3 inflammasome ligands. Experiments were repeated after 3 and 6months. Cytokine production was measured in cell supernatants; pro-interleukin(IL)-1 β was measured in cell lysates...
December 2, 2016: Cytokine
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