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https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#1
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29243536/variation-in-pediatric-organ-donor-management-practices-among-us-organ-procurement-organizations
#2
Robert S Ream, Eric S Armbrecht
INTRODUCTION: Reports of actual pediatric organ donor management practice among US organ procurement organizations are sparse, and the use of standardized management guidelines is unknown. A recent consensus statement from the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations offers guidelines for the management of the pediatric organ donor. RESEARCH QUESTION: To describe the use of guidelines and routine practices in the management of the pediatric organ donor with respect to hemodynamics, lung and ventilator management, fluid and electrolytes, hormonal replacement therapy, the use of blood products, thermoregulation, and prophylactic antibiotics...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29243325/camp-based-multi-component-intervention-for-families-of-young-children-with-type-1-diabetes-a-pilot-and-feasibility-study
#3
Olga T Gupta, Marsha MacKenzie, Angie Burris, Bonnie B Jenkins, Nikki Collins, Molly Shade, Eileen Santa-Sosa, Sunita M Stewart, Perrin C White
BACKGROUND: Managing type 1 diabetes mellitus (T1DM) in preschool-aged children has unique challenges that can negatively impact glycemic control and parental coping. OBJECTIVE: To evaluate the impact of a camp-based multi-component intervention on glycated hemoglobin A1c (HbA1c) in young children with T1DM and psychosocial measures for their parents. SUBJECTS AND METHODS: Two separate cohorts of 18 children (ages 3-5 years) and their families participated in a camp-based intervention that included didactic and interactive parent education, child-centered education and family-based recreational activities...
December 15, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29241887/basal-insulin-regimens-for-adults-with-type-1-diabetes-mellitus-a-cost-utility-analysis
#4
Dalia Dawoud, Elisabetta Fenu, Bernard Higgins, David Wonderling, Stephanie A Amiel
OBJECTIVES: To assess the cost-effectiveness of basal insulin regimens for adults with type 1 diabetes mellitus in England. METHODS: A cost-utility analysis was conducted in accordance with the National Institute for Health and Care Excellence reference case. The UK National Health Service and personal and social services perspective was used and a 3.5% discount rate was applied for both costs and outcomes. Relative effectiveness estimates were based on a systematic review of published trials and a Bayesian network meta-analysis...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241843/quantifying-the-effect-of-diabetes-on-surgical-hand-and-forearm-infections
#5
Ketan Sharma, Deng Pan, James Friedman, Jenny L Yu, Aaron Mull, Amy M Moore
PURPOSE: Diabetes has long been established as a risk factor for hand and forearm infections. The purpose of this study was to review the effect of glycemic factors on outcomes among diabetic patients with surgical upper-extremity infections. We hypothesized that diabetic inpatients may benefit from stronger peri-infection glycemic control. METHODS: A prospective cohort study enrolled diabetic and nondiabetic surgical hand and forearm infections over 3 years. Glycemic factors included baseline glycosylated hemoglobin, blood glucose (BG) at presentation, and inpatient BG...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29241502/recruitment-and-retention-of-a-challenging-population-lessons-learned-and-design-implications
#6
Denise Soltow Hershey, Sarah L Hession
PURPOSE: The purpose of this article is share the lessons learned from recruiting and retaining adults with type 2 diabetes and solid tumor cancer into a longitudinal study exploring the relationship among chemotherapy, glycemic control, and symptoms. DESIGN/METHODS: Twelve-week longitudinal study, recruited thirty-four adults 21years or older with pre-existing type 2 diabetes and a solid tumor cancer, from three community based cancer centers who were eligible to receive outpatient chemotherapy...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29241373/agreement-between-the-point-of-care-tests-for-microalbuminuria-and-hba1c-performed-in-mexican-family-medicine-units-and-the-results-of-standard-laboratory-tests
#7
Leticia A Valdez-González, Araceli Méndez-Padrón, Rita A Gómez-Díaz, Adán Valladares-Salgado, Martha Catalina Sánchez-Becerra, Rafael Mondragón-González, Jaime Hernández-Rubí, Arturo González-Hermosillo, Miguel Cruz, Víctor Borja, Niels H Wacher
The albumin-creatinine ratio is considered an indicator of microalbuminuria, precursor to chronic kidney disease, while HbA1c is used to measure glycemic control. Given the prevalence of diabetes-related nephropathy, spot testing of albumin has long been recommended as a preventative measure, for the timely detection of microalbuminuria. However, many countries do not have this testing available in primary care, and sometimes not even in second- and third-level care. The objective of this study was to compare agreement of the microalbuminuria and HbA1c results obtained in the laboratory with 'gold standard' techniques, with those obtained on site with a 'Point of Care' DCA Vantage™ device by Siemens...
December 15, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29241364/health-benefits-of-pistachios-consumption
#8
Simona Terzo, Sara Baldassano, Gaetano Felice Caldara, Vincenzo Ferrantelli, Gianluigi Lo Dico, Flavia Mulè, Antonella Amato
The health benefits of nuts, mainly in relation to the improvement of dysmetabolic conditions such as obesity, type 2 diabetes mellitus and the related cardiovascular diseases, have been widely demonstrated. Compared to other nuts, pistachios have a lower fat and caloric content, and contain the highest levels of unsaturated fatty acids, potassium, γ-tocopherol, phytosterols and xanthophyll carotenoids, all substances that are well known for their antioxidant and anti-inflammatory actions. This variety of nutrients contributes to the growing body of evidence that the consumption of pistachios improves health, leading to a greater potential of healthy antioxidant and anti-inflammatory activity, glycemic control, and endothelial function...
December 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29241206/a-multicenter-experience-with-long-acting-somatostatin-analogues-in-patients-with-congenital-hyperinsulinism
#9
Ivo van der Steen, Mirjam E van Albada, Klaus Mohnike, Henrik Thybo Christesen, Susann Empting, Maria Salomon-Estebanez, Amalie Greve Rasmussen, Annemarie Verrijn Stuart, Annelieke A A van der Linde, Indraneel Banerjee, Annemieke M Boot
BACKGROUND/AIMS: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment. Long-acting somatostatin analogues have been used in children as off-label medication. However, the efficacy, outcomes, and adverse effect profiles of long-acting somatostatin analogues have not been described in multicentered studies. The aim of this retrospective study is to summarize the experience with long-acting somatostatin analogues in a large group of children with CHI...
December 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29239249/the-association-of-perioperative-glycemic-control-with-postoperative-surgical-site-infection-following-open-carpal-tunnel-release-in-patients-with-diabetes
#10
Brian C Werner, Victor A Teran, Jourdan Cancienne, D Nicole Deal
BACKGROUND: The primary goal of the study was to evaluate the association of hemoglobin A1c (HbA1c) levels in diabetic patients with the incidence of surgical site infection (SSI) following open carpal tunnel release (CTR). Our secondary objective was to calculate an HbA1c level in diabetic patients that predicted SSI after open CTR. METHODS: A national private-payer insurance database was queried for patients who underwent open CTR using Current Procedural Terminology (CPT) code 64721...
December 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29238721/macrovascular-complications-in-patients-with-diabetes-and-prediabetes
#11
REVIEW
Dou Huang, Marwan Refaat, Kamel Mohammedi, Amin Jayyousi, Jassim Al Suwaidi, Charbel Abi Khalil
Diabetes is a significant health problem worldwide, and its association with cardiovascular disease (CVD) was reported in several studies. Hyperglycemia and insulin resistance seen in diabetes and prediabetes lead to an increase in reactive oxygen species, which triggers intracellular molecular signaling. The resulting prothrombotic state and increase in inflammatory mediators expedite atherosclerotic changes and the development of macrovascular complications. Individuals with diabetes or prediabetes have a higher risk of developing myocardial infarction, stroke, and peripheral artery disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238514/diagnostic-value-of-glycemic-markers-hba1c-1-5-anhydroglucitol-and-glycated-albumin-in-evaluating-gestational-diabetes-mellitus
#12
Baris Saglam, Sezer Uysal, Sadik Sozdinler, Omer Erbil Dogan, Banu Onvural
Background: The oral glucose tolerance test (OGTT) is the current established method performed worldwide to diagnose gestational diabetes mellitus (GDM). The purpose of this study was to assess the utility of the use of long- and short-term markers of glycemic status. Methods: The study group was composed of 80 pregnant women, 40 with GDM and 40 with normal glucose tolerance. GDM was diagnosed with the American Diabetes Association criteria. Glycemic markers were measured in the OGTT blood samples of women at 24-28 weeks of gestation...
December 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29235010/metabolic-changes-up-to-10%C3%A2-years-after-gastric-bypass
#13
Daniela Vicinansa Mônaco-Ferreira, Vânia Aparecida Leandro-Merhi, Nilton César Aranha, Andre Brandalise, Nelson Ary Brandalise
OBJECTIVE: The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass. METHOD: A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234979/neuroprotective-effects-of-moringa-oleifera-bio-guided-gc-ms-identification-of-active-compounds-in-diabetic-neuropathic-pain-model
#14
Karim Raafat, Fadi Hdaib
OBJECTIVES: To explore the phytotherapeutic-activities of Moringa oleifera (MO) seeds on painful diabetic neuropathy in alloxan-induced diabetic mice. METHODS: The bio-guided fractionation of MO utilizing column chromatography aided with GC-MS was used to detect the most active constituent of MO. Hyperalgesia, using tail-flick and hot-plate latency experiments, and mechanical-allodynia, utilizing von-Frey filaments, were evaluated before and after 8 weeks of intraperitoneal alloxan administration (180 mg/kg)...
December 12, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29234210/pharmaceutical-approval-update
#15
Michele B Kaufman
Secnidazole (Solosec) for the one-dose treatment of bacterial vaginosis; triamcinolone acetonide extended-release injection (Zilretta) for osteoarthritis knee pain; and insulin aspart injection (Fiasp), a rapidacting human insulin analogue for glycemic control in diabetes mellitus.
December 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29232436/cellular-versus-acellular-grafts-for-diabetic-foot-ulcers-altering-the-protocol-to-improve-recruitment-to-a-comparative-efficacy-trial
#16
Catherine N Tchanque-Fossuo, Sara E Dahle, Hadar Lev-Tov, Chin-Shang Li, R Rivkah Isseroff
Diabetic foot ulcers (DFUs) have a substantial impact on public health. The standard of care (SOC) for DFUs consists of a multidisciplinary approach involving glycemic control, wound care with debridement of necrotic tissue, application of a moist dressing, infection control, use of off-loading devices, and patient education. New therapeutic devices aim to target the extracellular matrix (ECM) that is impaired in DFU; however, there is insufficient data on the effectiveness of such therapies along with lack of evidence on their long-term effectiveness...
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29232262/intermittent-versus-continuous-feeding-in-critically-ill-adults
#17
Jayshil J Patel, Martin D Rosenthal, Daren K Heyland
PURPOSE OF REVIEW: Early enteral nutrition is recommended in critically ill adult patients. The optimal method of administering enteral nutrition remains unknown. Continuous enteral nutrition administration in critically ill patients remains the most common practice worldwide; however, its practice has recently been called into question in favor of intermittent enteral nutrition administration, where volume is infused multiple times per day. This review will outline the key differences between continuous and intermittent enteral nutrition, describe the metabolic responses to continuous and intermittent enteral nutrition administration and outline recent studies comparing continuous with intermittent enteral nutrition administration on outcomes in critically ill adults...
December 11, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29230944/improved-insulin-sensitivity-appears-to-remain-for-a-mean-of-four-years-following-islet-cell-transplant-for-type-1-diabetes
#18
Brett Rydzon, Rebecca S Monson, Jose Oberholzer, Krista A Varady, Melena D Bellin, Kirstie K Danielson
BACKGROUND: Impaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). IS improves shortly after islet cell transplant for type 1 diabetes, yet long-term changes in IS, and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown. METHODS: Up to nine years (mean four) of longitudinal data were available on 22 adults (18 female) with T1D who received 1-3 transplants in Phase 1/2 or 3 clinical trials (2004-2014)...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29230472/individualized-glycemic-control-for-u-s-adults-with-type-2-diabetes-a-cost-effectiveness-analysis
#19
Neda Laiteerapong, Jennifer M Cooper, M Reza Skandari, Philip M Clarke, Aaron N Winn, Rochelle N Naylor, Elbert S Huang
Background: Intensive glycemic control in type 2 diabetes (glycated hemoglobin [HbA1c] level <7%) is an established, cost-effective standard of care. However, guidelines recommend individualizing goals on the basis of age, comorbidity, diabetes duration, and complications. Objective: To estimate the cost-effectiveness of individualized control versus uniform intensive control (HbA1c level <7%) for the U.S. population with type 2 diabetes. Design: Patient-level Monte Carlo-based Markov model...
December 12, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29228822/effects-of-an-herbal-combination-on-glycemic-control-and-lipid-profile-in-diabetic-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#20
Reyhaneh Shokoohi, Saeed Kianbakht, Mohammad Faramarzi, Masoud Rahmanian, Farzaneh Nabati, Saeed Mehrzadi, Hasan Fallah Huseini
The present study was conducted to explore the efficacy and safety of a herbal combination in the treatment of women with hyperlipidemic type 2 diabetes. The herbal combination capsule (600 mg) contained Terminalia chebula fruit extract (200 mg), Commiphora mukul (200 mg), and Commiphora myrrha oleo-gum-resin (200 mg), and the placebo capsule contained 600 mg toast powder. The patients in one group took the herbal combination and those in the other group took placebo capsules 3 times a day for 3 months. In the herbal combination-treated patients, the fasting blood glucose, total cholesterol, and low-density lipoprotein cholesterol levels were decreased and hidh-density lipoprotein cholesterol levels was increased significantly at the endpoint compared with the placebo and baseline...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
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