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https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#1
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29912999/implications-of-cardiovascular-outcomes-trials-in-type-2-diabetes-for-primary-care
#2
Jeff Unger
Patients with type 2 diabetes (T2D) are at a greater risk of cardiovascular (CV) morbidity and mortality than their counterparts without diabetes. Worsening glycemic control is associated with increasing risk of CV events and mortality, but glycemic control alone does not appear sufficient to improve CV outcomes. Furthermore, some glucose-lowering drugs have been associated with an increased risk of CV events. As a result, the US Food and Drug Administration (FDA) issued guidance in 2008 for the investigation of CV risk with new diabetes therapies...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912997/clinical-efficacy-of-once-weekly-glucagonlike-peptide-1-receptor-agonists-in-patients-with-type-2-diabetes
#3
Timothy S Bailey
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are indicated for restoring normoglycemia in patients with type 2 diabetes (T2D). This review analyzed and compared the efficacy results from 30 trials with the once-weekly (OW) GLP-1 RAs albiglutide, dulaglutide, exenatide extended-release (ER) and semaglutide. The 4 OW GLP-1 RAs showed a higher reduction in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and body weight, when compared to placebo. Semaglutide significantly reduced the HbA1c level (estimated treatment difference [ETD]: -0...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912996/the-pharmacokinetic-properties-of-glucagon-like-peptide-1-receptor-agonists-and-their-mode-and-mechanism-of-action-in-patients-with-type-2-diabetes
#4
John Anderson
Once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated improved glycemic control in patients with type 2 diabetes (T2D), and some have a number of other benefits, including weight loss, improvements in blood pressure and lipid profiles, and cardiovascular protection. They also provide a therapy option with a low risk of hypoglycemia, an attractive choice for many patients. Molecular structure and pharmacokinetic properties vary among GLP-1 RAs, with some more closely related than others to native glucagon-like peptide-1 (GLP-1)...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912995/an-overview-of-the-burden-of-illness-and-the-role-of-once-weekly-glucagon-like-peptide-1-receptor-agonists-in-the-treatment-of-type-2-diabetes
#5
Stephen A Brunton
Type 2 diabetes (T2D) is a debilitating condition and more people are being diagnosed each year. T2D increases patients' risk of developing disabling micro- and macrovascular complications, significantly reduces patients' quality of life, and is a substantial global economic burden. The efficacy and safety of antihyperglycemic therapies have improved over the years and have increased the lifespan for these patients. Consequently, patients are living longer with the condition and the associated comorbidities, but with a lowered quality of life...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29911959/conversion-from-steroid-to-everolimus-in-maintenance-kidney-transplant-recipients-with-posttransplant-diabetes-mellitus
#6
Koji Nanmoku, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Takashi Yagisawa
OBJECTIVES: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy. MATERIALS AND METHODS: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg)...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29911762/triglycerides-free-fatty-acids-and-glycemic-control-an-unresolved-puzzle
#7
EDITORIAL
Micha J Rapoport, Andreas E Buchs
No abstract text is available yet for this article.
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911451/effect-of-well-controlled-gestational-diabetes-on-left-ventricular-diastolic-dysfunction-in-neonates
#8
Yazdan Ghandi, Danial Habibi, Khadijeh Nasri, Saeed Alinejad, Hassan Taherahmad, Ali Arjmand Shabestari, Ali Nematinejad
BACKGROUND: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium. MATERIALS AND METHODS: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth...
June 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29911044/advanced-diabetic-nephropathy-with-clean-eyes-an-extreme-phenotype
#9
Debmalya Sanyal, Sudip Chatterjee
Introduction: It is generally accepted that renal and eye changes in diabetes are concordant. There are however a fair number of patients with diabetes who have end-stage renal disease (ESRD) without any of the typical eye changes. The present study highlights the discordance between retinopathy and nephropathy and describes a series of patients of long-standing diabetes undergoing renal transplant who had little or no evidence of retinopathy. Methods: All patients with ESRD undergoing renal transplants underwent comprehensive fundus evaluation including dilated indirect ophthalmoscopy, slit lamp biomicroscopy, and fundus photography...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910582/management-of-hyperglycemia-during-and-in-the-immediate-follow-up-of-acute-coronary-syndrome
#10
REVIEW
Jamal El Ouazzani, Amine Ghalem, Ghizlane El Ouazzani, Nabila Ismaili, Noha El Ouafi
Diabetes is a serious, frequent, and insidious morbidity and mortality risk factor in patients with coronary artery disease. It has been shown that carbohydrate metabolism disorders are common in acute coronary syndromes (ACSs): 30-40% of patients have diabetes, 25-36% have an intolerance to carbohydrates, and only 30-40% have a normal carbohydrate profile. Hyperglycemia occurring either in diabetic or nondiabetic patients is strongly associated with a poor prognosis. It increases the extent of myocardial necrosis, and the risk of recurrence acute coronary syndrome and hemodynamic complications, particularly heart failure and cardiogenic shock, reflecting the importance of optimal management of glucose metabolism abnormalities...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910418/are-we-compensating-for-the-lack-of-physical-activity-in-our-diabetic-patients-with-treatment-intensification
#11
Maja Cigrovski Maja Cigrovski Berkovic, Ines Bilic-Curcic, Marina Gradiser, Davorka Herman-Mahecic, Vjekoslav Cigrovski, Marul Ivandic
BACKGROUND: We studied the association between leisure time physical activity (LTPA) and glycemic control, body mass index (BMI), and hypoglycemic incidents in type 1 (T1DM) and type 2 diabetes patients (T2DM). METHODS: This is a cross-sectional study of 198 diabetic patients (60 with type 1 diabetes, 138 with type 2 diabetes). LTPA was assessed by a validated 12-month questionnaire. Patients were grouped as sedentary and moderately to vigorously active. Outcome measures were Hemoglobin A1c (HbA1c), BMI, and hypoglycemic episodes...
August 7, 2017: Sports (Basel)
https://www.readbyqxmd.com/read/29909748/effect-of-telemedicine-intervention-on-hypoglycaemia-in-diabetes-patients-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#12
Yuli Hu, Xiaohong Wen, Feifei Wang, Dongliang Yang, Shanshan Liu, Pan Li, Juling Xu
Introduction Hypoglycaemia is a clinical syndrome from various causes, which happens when the blood glucose concentration is too low. Many studies show that telemedicine intervention can improve glycemic control and has a positive impact on the management of diabetic patients. The purpose of this study was to evaluate the effect of telemedicine intervention on hypoglycemic event occurrences and results on hemoglobin A1c (HbA1c) and body mass index (BMI). Methods We searched the Cochrane Library, PubMed, Web of Science, the EBSCO host, and OVID to identify relevant studies published from January 2006 to December 2017...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29909550/methods-for-measuring-risk-for-type-2-diabetes-in-youth-the-oral-glucose-tolerance-test-ogtt
#13
REVIEW
Melinda E Chen, Rebecca S Aguirre, Tamara S Hannon
PURPOSE OF REVIEW: The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunction in obesity, prediabetes, and type 2 diabetes. Here we review the use of the OGTT and the OGTT-derived indices for measurement of risk markers for type 2 diabetes in youth...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909445/centers-for-disease-control-and-prevention-2017-guidelines-for-prevention-of-surgical-site-infections-review-and-relevant-recommendations
#14
REVIEW
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29909034/particle-size-affects-structural-and-in-vitro-digestion-properties-of-cooked-rice-flours
#15
Adil Muhammad Farooq, Chao Li, Siqian Chen, Xiong Fu, Bin Zhang, Qiang Huang
The aim of this study was to identify the contributions made by size fractions of four milled rice (i.e., waxy, white, black and brown rice) to structural and in vitro starch digestion properties after cooking. Rice grains were hammer-milled in a controlled manner, and the coarse (300-450 μm), medium (150-300 μm) and fine size (<150 μm) fractions were segregated through vertical sieving. All samples displayed monophasic digestograms, and starch digestion rate and extent for size fractionated rice flours were predicted through the Logarithm of Slope model...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29907898/inpatient-glycemic-management-of-non-cardiac-cvd-focus-on-stroke-and-pvd
#16
REVIEW
Estelle Everett, Nestoras Mathioudakis
PURPOSE OF REVIEW: Hyperglycemia occurs frequently in hospitalized patients with stroke and peripheral vascular disease (PVD). Guidelines for inpatient glycemic management are not well established for this patient population. We will review the clinical impact of hyperglycemia in this acute setting and review the evidence for glycemic control. RECENT FINDINGS: Hyperglycemia in acute stroke is associated with poor short and long-term outcomes, and perioperative hyperglycemia in those undergoing revascularization for PVD is linked to increased post-surgical complications...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29907885/recognition-and-control-of-hypertension-diabetes-and-dyslipidemia-in-patients-with-rheumatoid-arthritis
#17
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29907582/social-network-characteristics-are-associated-with-type-2-diabetes-complications-the-maastricht-study
#18
Stephanie Brinkhues, Nicole H T M Dukers-Muijrers, Christian J P A Hoebe, Carla J H van der Kallen, Annemarie Koster, Ronald M A Henry, Coen D A Stehouwer, Paul H M Savelkoul, Nicolaas C Schaper, Miranda T Schram
OBJECTIVE: The relation between clinical complications and social network characteristics in type 2 diabetes mellitus (T2DM) has hardly been studied. Therefore, we examined the associations of social network characteristics with macro- and microvascular complications in T2DM and investigated whether these associations were independent of glycemic control, quality of life, and well-known cardiovascular risk factors. RESEARCH DESIGN AND METHODS: Participants with T2DM originated from the Maastricht Study, a population-based cohort study ( n = 797, mean age 62...
June 15, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#19
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29903690/different-strategies-for-detection-of-hba1c-emphasizing-on-biosensors-and-point-of-care-analyzers
#20
Jagjit Kaur, Cheng Jiang, Guozhen Liu
Measurement of glycosylated hemoglobin (HbA1c) is a gold standard procedure for assessing long term glycemic control in individuals with diabetes mellitus as it gives the stable and reliable value of blood glucose levels for a period of 90-120 days. HbA1c is formed by the non-enzymatic glycation of terminal valine of hemoglobin. The analysis of HbA1c tends to be complicated because there are more than 300 different assay methods for measuring HbA1c which leads to variations in reported values from same samples...
June 7, 2018: Biosensors & Bioelectronics
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