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systolic functions in neonates

Ulrike Herberg, Katharina Linden, Oliver Dewald, Eva Gatzweiler, Matthias Seehase, Georg Daniel Duerr, Jonas Dörner, Stephanie Kleppe, Dennis Ladage, Johannes Breuer
BACKGROUND: Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data...
2016: PloS One
Joseph B Fisher, Audrey Horst, Tina Wan, Min-Su Kim, John Auchampach, John Lough
Tat-interactive protein 60 (Tip60), encoded by the Kat5 gene, is a member of the MYST family of acetyltransferases. Cancer biology studies have shown that Tip60 induces the DNA damage response, apoptosis, and cell-cycle inhibition. Although Tip60 is expressed in the myocardium, its role in cardiomyocytes (CMs) is unclear. Earlier studies here showed that application of cardiac stress to globally targeted Kat5+/-haploinsufficient mice resulted in inhibition of apoptosis and activation of the CM cell-cycle, despite only modest reduction of Tip60 protein levels...
2016: PloS One
Muhammad Oneeb Rehman Mian, Julie Demeulemeester, Jean-Luc Bigras, Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Rong Wu, Anik Cloutier, Thuy Mai Luu, Anne-Monique Nuyt
OBJECTIVE: Studies support a direct causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass, and impaired systolic and diastolic function were observed in young adults born preterm. Deleterious neonatal conditions, as in preterm birth, could significantly impact on myocardial tissue. We investigated how left ventricle (LV) echocardiographic parameters in young adults born preterm correlated with neonatal health parameters and interventions data...
September 2016: Journal of Hypertension
Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A Boon, Leon J de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum
BACKGROUND: Aging populations show higher incidences of myocardial infarction (MI) and heart failure (HF). Cardiac remodeling post-MI leads to progressive impaired cardiac function caused by a disarray of several processes including derailed autophagy. Microribonucleic acids (miRNAs) are known to be key players in cardiovascular disease but their involvement in cardiac autophagy and aging is not well understood. OBJECTIVES: This study sought to identify new miRNA candidates that regulate cardiac autophagy and aging...
October 4, 2016: Journal of the American College of Cardiology
Muhammad Oneeb Rehman Mian, Julie Demeulemeester, Jean-Luc Bigras, Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Rong Wu, Anik Cloutier, Thuy Mai Luu, Anne-Monique Nuyt
OBJECTIVE: Studies support a direct causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass, and impaired systolic and diastolic function were observed in young adults born preterm. Deleterious neonatal conditions, as in preterm birth, could significantly impact on myocardial tissue. We investigated how left ventricle (LV) echocardiographic parameters in young adults born preterm correlated with neonatal health parameters and interventions data...
September 2016: Journal of Hypertension
Rashmi Pilania, Pooja Sikka, Manoj K Rohit, Vanita Suri, Praveen Kumar
INTRODUCTION: Maternal diabetes mellitus is associated with an increased risk of fetal and neonatal morbidity and mortality. Usual screening tests have not proved to be good prognostic indicators of fetal distress. Fetal cardiodynamics is potentially a useful screening tool. AIM: To determine if cardiodynamics of the fetus differ in pregnancy with diabetes requiring insulin than those without and to determine whether cardiodynamics predict fetal and neonatal outcomes...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Jiao Chen, Liang Xie, Li Dai, Li Yu, Lijun Liu, Yongbi Zhou, Guiying Wu, Fengfei Qin, Hanmin Liu
The objective of this study was to detect the effect of a large ventricular septal defect (VSD) on right ventricular function before and after birth. All consecutive children with large VSD who were born in our hospital between January 2013-February 2016 and followed up throughout early infancy, and who lacked malformations or chromosomal abnormalities, were identified by a retrospective review of the medical records and included in this retrospective longitudinal case-control study (n = 30). Thirty normal control cases with an equivalent gestational age and gender served as controls...
August 25, 2016: Pediatric Cardiology
Narges L Horriat, Sara L Deatsman, Jessica Stelter, Peter C Frommelt, Garick D Hill
Initial surgical strategies in neonates with single left ventricular (LV) anatomy vary based on adequacy of pulmonary and systemic blood flow. Differing myocardial responses to these strategies, as reflected in indices of systolic function, ventricular size, and mass have not been well defined. We sought to evaluate single LV myocardial response to varied physiology and initial palliation and determine whether the response is consistent and predictable. Infants with single LV physiology were divided based on neonatal palliation: no palliation/PA band (NO); BT shunt only (BT); or Norwood procedure (NP)...
August 23, 2016: Pediatric Cardiology
Dong Fan, Abhijit Takawale, Mengcheng Shen, Victor Samokhvalov, Ratnadeep Basu, Vaibhav Patel, Xiuhua Wang, Carlos Fernandez-Patron, John M Seubert, Gavin Y Oudit, Zamaneh Kassiri
A disintegrin and metalloprotease-17 (ADAM17) belongs to a family of transmembrane enzymes, and it can mediate ectodomain shedding of several membrane-bound molecules. ADAM17 levels are elevated in patients with hypertrophic and dilated cardiomyopathy; however, its direct role in hypertrophic cardiomyopathy is unknown. Cardiomyocyte-specific ADAM17 knockdown mice (ADAM17(flox/flox)/αMHC-Cre; ADAM17(f/f)/Cre) and littermates with intact ADAM17 levels (ADAM17(f/f)) were subjected to cardiac pressure-overload by transverse aortic constriction...
October 2016: Hypertension
Tomomasa Terada, Kazuhiro Mori, Miki Inoue, Hayabuchi Yasunobu
BACKGROUND: Assessment of longitudinal left ventricular (LV) function is important for early detection of cardiac dysfunction. Although mitral annular plane systolic excursion (MAPSE) obtained by M-mode echocardiography offers a simple method for assessing longitudinal LV function, normal values of MAPSE for children change according to body size. METHODS: To minimize the effects of body size, MAPSE was divided by LV long-axis length (MAPSE/L). MAPSE/L was measured in 210 healthy children from birth to 15 years of age and classified into five subgroups...
August 22, 2016: Echocardiography
Mahboubeh Ghanbari, Fatemeh Bagheripuor, Abbas Piryaei, Saleh Zahediasl, Mahsa Noroozzadeh, Asghar Ghasemi
Thyroid hormones (THs) play a crucial role in the development of different systems during fetal life; fetal hypothyroidism (FH) is associated with reduced cardiac function and dimensions in neonates. The aim of this study is to determine whether TH deficiency during fetal life is associated with arterial structural and hemodynamic changes during adulthood. Hypothyroidism was induced by adding 0.025% 6-propyl-2-thiouracil in drinking water throughout pregnancy, while controls consumed only tap water. Hemodynamic parameters, cross-sectional area, intima-media thickness (IMT), and density of nuclei of smooth muscle cells and endothelial cells (ECs) in the aorta and mesenteric arteries were measured...
August 16, 2016: General Physiology and Biophysics
Vassilios J Bezzerides, Colin Platt, Carolin Lerchenmüller, Kaavya Paruchuri, Nul Loren Oh, Chunyang Xiao, Yunshan Cao, Nina Mann, Bruce M Spiegelman, Anthony Rosenzweig
The mechanisms by which exercise mediates its multiple cardiac benefits are only partly understood. Prior comprehensive analyses of the cardiac transcriptional components and microRNAs dynamically regulated by exercise suggest that the CBP/p300-interacting protein CITED4 is a downstream effector in both networks. While CITED4 has documented functional consequences in neonatal cardiomyocytes in vitro, nothing is known about its effects in the adult heart. To investigate the impact of cardiac CITED4 expression in adult animals, we generated transgenic mice with regulated, cardiomyocyte-specific CITED4 expression...
June 16, 2016: JCI Insight
Jiajia Dong, Cuixia Gao, Jing Liu, Yunshan Cao, Limin Tian
Elevated thyroid-stimulating hormone (TSH) levels often accompany impaired LV diastolic function and subtle systolic dysfunction in subclinical hypothyroidism (sHT). These cardiac dysfunctions are characterized by increases in mean aortic acceleration and pre-ejection/ejection time ratios. To explore the mechanism underlying these pathologies, we investigated the effects of TSH on sarcoplasmic reticulum calcium ATPase (SERCA2a) activity and expression in neonatal rat cardiomyocytes. TSH inhibited SERCA2a activity and expression by binding to TSH receptors in cardiomyocyte membranes and inhibiting the protein kinase A/phoshpolamban (PKA/PLN) signaling pathway...
May 16, 2016: Oncotarget
Udit Agarwal, Amanda W Smith, Kristin M French, Archana V Boopathy, Alex George, David Trac, Milton E Brown, Ming Shen, Rong Jiang, Janet D Fernandez, Brian E Kogon, Kirk R Kanter, Baahaldin Alsoufi, Mary B Wagner, Manu O Platt, Michael E Davis
UNLABELLED: Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years)...
July 2016: Stem Cells Translational Medicine
Renata Bokiniec, Paweł Własienko, Maria Katarzyna Borszewska-Kornacka, Dariusz Madajczak, Joanna Szymkiewicz-Dangel
BACKGROUND: The myocardial performance index (MPI) is a noninvasive method to measure global systolic and diastolic myocardial function. In both term and premature neonates, changes in the systolic and diastolic function of the left ventricle (LV) and right ventricle (RV) reflect the degree of neonatal myocardial immaturity and the co-existence of foetal circulation. AIM: To assess MPI (or Tei indices) of both ventricles in term and preterm newborns, and to observe MPI trends throughout the neonatal period...
2016: Kardiologia Polska
Brody Wehman, Sudhish Sharma, Nicholas Pietris, Rachana Mishra, Osama T Siddiqui, Grace Bigham, Tieluo Li, Emily Aiello, Sarah Murthi, Mark Pittenger, Bartley Griffith, Sunjay Kaushal
Limited therapies exist for patients with congenital heart disease (CHD) who develop right ventricular (RV) dysfunction. Bone marrow-derived mesenchymal stem cells (MSCs) have not been evaluated in a preclinical model of pressure overload, which simulates the pathophysiology relevant to many forms of CHD. A neonatal swine model of RV pressure overload was utilized to test the hypothesis that MSCs preserve RV function and attenuate ventricular remodeling. Immunosuppressed Yorkshire swine underwent pulmonary artery banding to induce RV dysfunction...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-Carrión, León Ferder, Walter Manucha
BACKGROUND: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' tumor 1 transcription factor (WT-1), could contribute to the development of hypertension. The aim of this paper is to evaluate the expression of WT-1 and related genes in the nephrogenic process in connection with the development of hypertension as well as the corresponding anatomical and functional correlation...
2016: BMC Nephrology
M A Ali, T Tazmin, T Latif, S A Haque, M A Hossain, M N Islam, R H Khan, M A Hoque
Cantrell's Pentalogy is a rare congenital malformation consists of supraumbilical abdominal wall defect, defect in the lower part of sternum, agenesis of anterior portion of diaphragm, an absence of the diaphragmatic part of the pericardium and intracardiac malformation. This case report presents a female neonate, who was born at 40 weeks of gestation weighing 2400 gm and was admitted 4 hours after delivery with the complaints of something coming out from chest. On physical examination her vital signs were within normal limit, she had a systolic murmur on heart at lower left sternal area and there was a vascular structure present on the upper part of abdomen which was pulsatile and pulsation was synchronized with cardiac pulsation...
January 2016: Mymensingh Medical Journal: MMJ
Kedak Baltajian, Surichhya Bajracharya, Saira Salahuddin, Anders H Berg, Carl Geahchan, Julia B Wenger, Ravi Thadhani, S Ananth Karumanchi, Sarosh Rana
BACKGROUND: Alterations in circulating angiogenic factors are associated with the diagnosis of preeclampsia and correlate with adverse perinatal outcomes during the third trimester. OBJECTIVE: Analysis of the sequential levels of plasma angiogenic factors among patients admitted for evaluation of preeclampsia. STUDY DESIGN: We performed an observational study among women with singleton pregnancies admitted to Beth Israel Deaconess Medical Center, Boston, Massachusetts, for evaluation of preeclampsia at less than 37 weeks of gestation...
July 2016: American Journal of Obstetrics and Gynecology
Christopher J Bugnitz, Yongjie Miao, Glen E Berger, Mark E Galantowicz, John P Cheatham, Clifford L Cua
AIMS: Decreased right ventricular function via deformation analysis has been noted in patients with hypoplastic left heart syndrome (HLHS) after the Norwood procedure. No data exist in HLHS patients undergoing the hybrid procedure. The goal of this study was to evaluate right ventricular functional changes in HLHS patients undergoing the hybrid procedure under steady-state conditions. METHODS AND RESULTS: Echocardiograms were prospectively obtained on patients with HLHS before and after the hybrid procedure...
January 22, 2016: European Heart Journal Cardiovascular Imaging
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