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systolic functions in neonates

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https://www.readbyqxmd.com/read/28295792/biventricular-impact-of-mild-to-moderate-pulmonary-valve-stenosis-in-fetal-life
#1
L Guirado, F Crispi, N Masoller, M Bennasar, E Marimon, J Carretero, E Gratacós, J M Martínez, M K Friedberg, O Gómez
OBJECTIVES: to define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate the echocardiographic findings with the neonatal outcome and the need of postnatal pulmonary valvuloplasty within the first 12 months of life. METHODS: a prospective cohort study was designed on 16 fetuses with isolated PS and 48 controls matched by gestational age at scan (+/- 2 weeks). Fetal standard ultrasound and comprehensive echocardiography, which included cardiovascular morphometric parameters, systolic and diastolic functional and timing-measurements, were performed in all cases...
March 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28285896/perinatal-changes-in-fetal-ventricular-geometry-myocardial-performance-and-cardiac-function-in-normal-term-pregnancies
#2
Olga Patey, Michael A Gatzoulis, Basky Thilaganathan, Julene S Carvalho
BACKGROUND: The fetal heart at term is exposed to an increase in hemodynamic work as a consequence of fetal growth, increased circulating volume, and alteration in loading patterns due to maturational changes in fetoplacental circulation. The extent to which these cardiovascular changes influence human fetal and neonatal cardiac adaptation has not been fully elucidated. The aim of this study was to evaluate perinatal cardiovascular changes in ventricular geometry and myocardial performance in normal term fetuses...
March 9, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28268110/impaired-single-right-ventricular-function-compared-to-single-left-ventricles-during-the-early-stages-of-palliation-a-longitudinal-study
#3
Somjate Suntratonpipat, Nee S Khoo, Timothy Colen, Mohammed Alhabdan, Dongngan Troung, Norazah Zahari, Shelby Kutty, Jeffrey F Smallhorn, Edythe B Tham
BACKGROUND: Single right ventricles (SRV) are postulated to be disadvantaged compared with single left ventricles (SLV). We compared the evolution of SRV versus SLV function during infancy using conventional measures and speckle tracking echocardiography (STE). We hypothesized that the SRV is mechanically disadvantaged during early infancy. METHODS: SRVs (n = 32) were compared with SLVs (n = 16) at the neonatal (presurgery) and pre-bidirectional cavopulmonary anastomosis (pre-BCPA) stages...
March 3, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28197645/subclinical-decrease-in-myocardial-function-in-asymptomatic-infants-of-diabetic-mothers-a-tissue-doppler-study
#4
Jenny E Zablah, Dorota Gruber, Guillaume Stoffels, Estefania G Cabezas, Denise A Hayes
Infants of diabetic mothers (IDMs) with hypertrophic cardiomyopathy are recognized to have impaired myocardial performance, but less is known about ventricular function in IDMs without hypertrophy. We hypothesized that in asymptomatic newborns with normal two-dimensional echocardiographic evaluations, pulsed wave tissue Doppler imaging (TDI) would suggest a subclinical decrease in the cardiac function of IDMs compared to infants of non-diabetics (nIDMs). This is a retrospective cohort study of asymptomatic neonates ≥36 weeks gestation, at 0-7 days of life, with normal standard echocardiograms...
February 14, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28190549/comparing-del-nido-and-conventional-cardioplegia-in-infants-and-neonates-in-congenital-heart-surgery
#5
Kamal K Pourmoghadam, Mark Ruzmetov, Michael C O'Brien, Kurt D Piggott, Gary Plancher, Sukumar Suguna Narasimhulu, Tavya Benjamin, William M Decampli
BACKGROUND: The aim of this study was to evaluate outcome measures after the use of del Nido (dN) cardioplegia compared with conventional multidose high-potassium (non-dN) cardioplegia in neonates and infants. METHODS: We retrospectively analyzed data in patients, aged younger than 1 year, undergoing cardiopulmonary bypass (CPB) from January 2012 to August 2015. We changed our cardioplegia protocol from non-dN to dN administered in a single or infrequently dosed strategy in September 2013...
February 9, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28174168/cardiac-overexpression-of-s100a6-attenuates-cardiomyocyte-apoptosis-and-reduces-infarct-size-after-myocardial-ischemia-reperfusion
#6
Azadeh Mofid, Nadav S Newman, Paul J H Lee, Cynthia Abbasi, Pratiek N Matkar, Dmitriy Rudenko, Michael A Kuliszewski, Hao H Chen, Kolsoom Afrasiabi, James N Tsoporis, Anthony O Gramolini, Kim A Connelly, Thomas G Parker, Howard Leong-Poi
BACKGROUND: Cardiomyocyte-specific transgenic mice overexpressing S100A6, a member of the family of EF-hand calcium-binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings that support S100A6 as a potential therapeutic target after acute myocardial infarction. Our purpose was to investigate S100A6 gene therapy for acute myocardial ischemia-reperfusion. METHODS AND RESULTS: We first performed in vitro studies to examine the effects of S100A6 overexpression and knockdown in rat neonatal cardiomyocytes...
February 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28018900/redox-regulation-of-heart-regeneration-an-evolutionary-tradeoff
#7
Waleed M Elhelaly, Nicholas T Lam, Mohamed Hamza, Shuda Xia, Hesham A Sadek
Heart failure is a costly and deadly disease, affecting over 23 million patients worldwide, half of which die within 5 years of diagnosis. The pathophysiological basis of heart failure is the inability of the adult heart to regenerate lost or damaged myocardium. Although limited myocyte turnover does occur in the adult heart, it is insufficient for restoration of contractile function (Nadal-Ginard, 2001; Laflamme et al., 2002; Quaini et al., 2002; Hsieh et al., 2007; Bergmann et al., 2009, 2012). In contrast to lower vertebrates (Poss et al...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#8
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
February 15, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27964765/arginine-vasopressin-therapy-in-hypotensive-neonates-and-infants-after-cardiac-surgery-response-is-unrelated-to-baseline-ventricular-function
#9
Ilias Iliopoulos, Saul Flores, J N Pratap, David S Cooper, Amy Cassedy, David P Nelson
We hypothesised that infants with ventricular dysfunction after cardiac surgery have impaired haemodynamic response to arginine-vasopressin therapy. We retrospectively reviewed the medical records of neonates and infants treated with arginine-vasopressin within 48 hours of corrective or palliative cardiac surgery who underwent echocardiographic assessment of ventricular function before initiation of therapy. Patients were classified as "responders" if their systolic blood pressure increased by ⩾10% without increase in catecholamine score or if it was maintained with decreased catecholamine score...
December 14, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27908646/left-ventricular-function-in-healthy-term-neonates-during-the-transitional-period
#10
Amish Jain, Afif F El-Khuffash, Bart C W Kuipers, Adel Mohamed, Kim A Connelly, Patrick J McNamara, Robert P Jankov, Luc Mertens
OBJECTIVES: To evaluate whether incorporating conventional, tissue Doppler imaging and speckle tracking echocardiography are reliable and can characterize changes in left ventricular (LV) function properly in healthy neonates in the early transitional newborn period. STUDY DESIGN: A prospective observational study was conducted in 50 healthy term neonates with a mean ± SD gestational age and birth weight of 39.3 ± 1.2 weeks and 3.5 ± 0.44 kg, respectively...
March 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27874244/coarctation-repair-normalizes-left-ventricular-function-and-aorto-septal-angle-in-neonates
#11
Haki Jashari, Katarina Lannering, Mats Mellander, Pranvera Ibrahimi, Annika Rydberg, Michael Y Henein
BACKGROUND AND AIMS: Patients with coarctation of the aorta (CoA) have increased left ventricular (LV) afterload that has been shown to impact the LV and ascending aortic function. We aimed to examine the effect of coarctation on LV function and aorto-septal angle (AoSA) before and after surgical repair. METHODS: We retrospectively studied 21 patients with surgically repaired CoA at a median age of 9 (2-53) days at three time points: (1) just before intervention, (2) at short-term follow-up, and (3) at medium-term follow-up after intervention...
November 22, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27851698/nitrite-prevents-right-ventricular-failure-and-remodeling-induced-by-pulmonary-artery-banding
#12
Jian Hu, Maryam Sharifi-Sanjani, Stevan P Tofovic
BACKGROUND: Nitrite has been shown to reduce right ventricle (RV) remodeling in experimental pulmonary hypertension. However, whether this effect is due to a reduction in RV afterload (ie, reduction in pulmonary artery pressure) or a direct effect on the RV itself remains unanswered. We hypothesize that nitrite has direct effects on RV remodeling and studied its effects in mice with pulmonary artery banding (PAB). METHODS AND RESULTS: PAB decreased exercise tolerance and reduced RV systolic and diastolic function...
February 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27798600/hypoxia-induces-heart-regeneration-in-adult-mice
#13
Yuji Nakada, Diana C Canseco, SuWannee Thet, Salim Abdisalaam, Aroumougame Asaithamby, Celio X Santos, Ajay M Shah, Hua Zhang, James E Faber, Michael T Kinter, Luke I Szweda, Chao Xing, Zeping Hu, Ralph J Deberardinis, Gabriele Schiattarella, Joseph A Hill, Orhan Oz, Zhigang Lu, Cheng Cheng Zhang, Wataru Kimura, Hesham A Sadek
The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the adult heart is capable of modest self-renewal. In both of these scenarios, cardiomyocyte renewal occurs via the proliferation of pre-existing cardiomyocytes, and is regulated by aerobic-respiration-mediated oxidative DNA damage...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27792267/very-low-birthweight-bronchopulmonary-dysplasia-survivors-had-similar-cardiac-outcomes-to-controls-at-six-years-to-14-years-of-age
#14
Piia Suursalmi, Anneli Eerola, Tuija Poutanen, Päivi Korhonen, Tarja Kopeli, Outi Tammela
AIM: This study evaluated cardiac function and its associations with lung function and neonatal pulmonary morbidity in very low birthweight (VLBW) children, with and without severe radiographic bronchopulmonary dysplasia (radBPD), at school age. METHODS: We examined 18 VLBW children with radBPD, 17 VLBW children without radBPD and 18 healthy term-born children using conventional echocardiography, tissue Doppler imaging, speckle tracking echocardiography and real-time three-dimensional echocardiography at six years to 14 years of age...
February 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27776179/3d-real-time-echocardiography-combined-with-mini-pressure-wire-generate-reliable-pressure-volume-loops-in-small-hearts
#15
Ulrike Herberg, Katharina Linden, Oliver Dewald, Eva Gatzweiler, Matthias Seehase, Georg Daniel Duerr, Jonas Dörner, Stephanie Kleppe, Dennis Ladage, Johannes Breuer
BACKGROUND: Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data...
2016: PloS One
https://www.readbyqxmd.com/read/27768769/depletion-of-tip60-from-in-vivo-cardiomyocytes-increases-myocyte-density-followed-by-cardiac-dysfunction-myocyte-fallout-and-lethality
#16
Joseph B Fisher, Audrey Horst, Tina Wan, Min-Su Kim, John Auchampach, John Lough
Tat-interactive protein 60 (Tip60), encoded by the Kat5 gene, is a member of the MYST family of acetyltransferases. Cancer biology studies have shown that Tip60 induces the DNA damage response, apoptosis, and cell-cycle inhibition. Although Tip60 is expressed in the myocardium, its role in cardiomyocytes (CMs) is unclear. Earlier studies here showed that application of cardiac stress to globally targeted Kat5+/-haploinsufficient mice resulted in inhibition of apoptosis and activation of the CM cell-cycle, despite only modest reduction of Tip60 protein levels...
2016: PloS One
https://www.readbyqxmd.com/read/27753874/yia-01-01-adverse-neonatal-health-correlates-with-long-term-cardiac-functional-and-structural-remodeling-in-young-adults-born-preterm
#17
Muhammad Oneeb Rehman Mian, Julie Demeulemeester, Jean-Luc Bigras, Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Rong Wu, Anik Cloutier, Thuy Mai Luu, Anne-Monique Nuyt
OBJECTIVE: Studies support a direct causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass, and impaired systolic and diastolic function were observed in young adults born preterm. Deleterious neonatal conditions, as in preterm birth, could significantly impact on myocardial tissue. We investigated how left ventricle (LV) echocardiographic parameters in young adults born preterm correlated with neonatal health parameters and interventions data...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27687198/preclinical-development-of-a-microrna-based-therapy-for-elderly-patients-with-myocardial-infarction
#18
Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A Boon, Leon J de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum
BACKGROUND: Aging populations show higher incidences of myocardial infarction (MI) and heart failure (HF). Cardiac remodeling post-MI leads to progressive impaired cardiac function caused by a disarray of several processes including derailed autophagy. Microribonucleic acids (miRNAs) are known to be key players in cardiovascular disease but their involvement in cardiac autophagy and aging is not well understood. OBJECTIVES: This study sought to identify new miRNA candidates that regulate cardiac autophagy and aging...
October 4, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27643111/yia-01-01-adverse-neonatal-health-correlates-with-long-term-cardiac-functional-and-structural-remodeling-in-young-adults-born-preterm
#19
Muhammad Oneeb Rehman Mian, Julie Demeulemeester, Jean-Luc Bigras, Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Rong Wu, Anik Cloutier, Thuy Mai Luu, Anne-Monique Nuyt
OBJECTIVE: Studies support a direct causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass, and impaired systolic and diastolic function were observed in young adults born preterm. Deleterious neonatal conditions, as in preterm birth, could significantly impact on myocardial tissue. We investigated how left ventricle (LV) echocardiographic parameters in young adults born preterm correlated with neonatal health parameters and interventions data...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27630907/fetal-cardiodynamics-by-echocardiography-in-insulin-dependent-maternal-diabetes-and-its-correlation-with-pregnancy-outcome
#20
Rashmi Pilania, Pooja Sikka, Manoj K Rohit, Vanita Suri, Praveen Kumar
INTRODUCTION: Maternal diabetes mellitus is associated with an increased risk of fetal and neonatal morbidity and mortality. Usual screening tests have not proved to be good prognostic indicators of fetal distress. Fetal cardiodynamics is potentially a useful screening tool. AIM: To determine if cardiodynamics of the fetus differ in pregnancy with diabetes requiring insulin than those without and to determine whether cardiodynamics predict fetal and neonatal outcomes...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
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