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Liping Tong, Katsuhiko Saito, Qixin Guo, Han Zhou, Xingmei Guo, Tongxiang Fan, Di Zhang
A correlation function between the Raman intensities and the nearest-neighbor mean-square relative displacement (MSRD) [Formula: see text] of local Bi-O bonds is successfully established based on x-ray absorption fine structure (XAFS) and temperature-dependent Raman spectra in the temperature range 77-300 K in amorphous and crystalline Gd2.95 Yb0.02 Bi0.02 Er0.01 Ga5 O12 . The structural symmetries of Gd2.95 Yb0.02 Bi0.02 Er0.01 Ga5 O12 are described by using [Formula: see text] of local Bi-O bonds. More importantly, Gd2...
February 23, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Ting-Ting Jiang, Lei Zhao, Ying Lin, Dong Zhou, Ling Wang, Guo-Qiang Sun, Mei Xiao
OBJECTIVE: To investigate the effects of gestational diabetes mellitus (GDM) on time to delivery and perinatal outcomes in full-term pregnancies underwent dinoprostone-induced labor. METHODS: GDM patients that underwent labor induction with dinoprostone vaginal inserts were retrospectively recruited. Full-term pregnancies with normal glucose tolerance (NGT) that underwent labor induction at the same period were recruited as control. Time to delivery and perinatal outcomes were compared between the two groups...
February 23, 2018: Clinical and Experimental Hypertension: CHE
Justyna Rogowska, Ewa Olkowska, Wojciech Ratajczyk, Lidia Wolska
Since the 1980 s, gadolinium based contrast agents (GBCA) are routinely used in magnetic resonance imaging (MRI) as stable chelates of the Gd3+ ion, without toxic effects. Generally, GBCAs are considered as some of the safest contrast agents. However, it has been observed that they can accumulate in patients tissue, bone and probably in brain (causing nephrogenic systemic fibrosis in patients with kidney failure, insufficiency and disturbance of calcium homeostasis in the organism). The GBCAs are predominantly removed renally without metabolization...
February 23, 2018: Environmental Toxicology and Chemistry
Jessica Sheehan Tangren, Camille E Powe, Jeffrey Ecker, Kate Bramham, Elizabeth Ankers, S Ananth Karumanchi, Ravi Thadhani
BACKGROUND AND OBJECTIVES: Kidney stones are associated with future development of hypertension, diabetes, and the metabolic syndrome. Our objective was to assess whether stone formation before pregnancy was associated with metabolic and hypertensive complications in pregnancy. We hypothesized that stone formation is a marker of metabolic disease and would be associated with higher risk for maternal complications in pregnancy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study of women who delivered infants at the Massachusetts General Hospital from 2006 to 2015...
February 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Ari Zimran, Michael Wajnrajch, Betina Hernandez, Gregory M Pastores
Taliglucerase alfa is an enzyme replacement therapy (ERT) approved for treatment of adult and paediatric patients with Type 1 Gaucher disease (GD) in several countries and the first plant cell-expressed recombinant therapeutic protein approved by the US Food and Drug Administration for humans. Here, we review the findings across six key taliglucerase alfa clinical studies. A total of 33 treatment-naïve adult patients were randomized to taliglucerase alfa 30 U/kg or 60 U/kg in a 9-month, multicentre, randomized, double-blind, parallel-group, dose-comparison pivotal study, after which eligible patients continued into two consecutive extension studies; 17 treatment-naïve adult patients completed 5 total years of treatment with taliglucerase alfa...
February 23, 2018: Orphanet Journal of Rare Diseases
Michela Meregaglia, Livia Dainelli, Helen Banks, Chiara Benedetto, Patrick Detzel, Giovanni Fattore
BACKGROUND: The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden of GDM from the Italian healthcare system perspective. METHODS: A model was built over the last pregnancy trimester (i.e., from the 28th gestational week until childbirth included). The National Hospital Discharge Database (2014) was accessed to estimate delivery outcome probabilities and inpatient costs in GDM and normal pregnancies (i...
February 23, 2018: BMC Pregnancy and Childbirth
Alberto Rancati, Claudio Angrigiani, Maurizio B Nava, Giuseppe Catanuto, Nicola Rocco, Fernando Ventrice, Julio Dorr
BACKGROUND: Augmented reality (AR) enables the superimposition of virtual reality reconstructions onto clinical images of a real patient, in real time. This allows visualization of internal structures through overlying tissues, thereby providing a virtual transparency vision of surgical anatomy. AR has been applied to neurosurgery, which utilizes a relatively fixed space, frames, and bony references; the application of AR facilitates the relationship between virtual and real data. Augmented Breast imaging (ABI) is described...
February 21, 2018: Minerva Chirurgica
Fulvia Baldinotti, Tiziana Cavallaro, Eleonora Dati, Giampiero I Baroncelli, Veronica Bertini, Angelo Valetto, Francesco Massart, Gian Maria Fabrizi, Giampietro Zanette, Diego Peroni, Silvano Bertelloni
BACKGROUND: In humans, Desert Hedgehog (DHH) gene mutations are a very rare cause of 46,XY gonadal dysgenesis (GD), eventually associated with peripheral neuropathy. PATIENTS AND METHODS: Clinical records of 12 patients with 46,XY GD and unknown genetic background were reviewed and a 46,XY woman with peripheral neuropathy was individuated. Her 46,XX sister affected by similar neuropathy was also investigated. Genomic DNA was extracted and DHH exons sequenced and analyzed...
February 22, 2018: Hormone Research in Pædiatrics
Cleyton Saialy Medeiros Cunha, Ygor Jacques Agra Bezerra da Silva, Maria Eugenia Ortiz Escobar, Clístenes Williams Araújo do Nascimento
The Itataia uranium-phosphate deposit is the largest uranium reserve in Brazil. Rare earth elements (REEs) are commonly associated with phosphate deposits; however, there are no studies on the concentrations of REEs in soils of the Itataia deposit region. Thus, the objective of the research was to evaluate the concentration and spatial variability of REEs in topsoils of Itataia phosphate deposit region. In addition, the influence of soil properties on the geochemistry of REEs was investigated. Results showed that relatively high mean concentrations (mg kg-1 ) of heavy REEs (Gd 6...
February 22, 2018: Environmental Geochemistry and Health
Martina Tripepi, Federico Capuana, Eliana Gianolio, Flavio Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime
Molecular imaging requires the specific accumulation of contrast agents at the target. To exploit the superb resolution of MRI for applications in molecular imaging, gadolinium chelates, as the MRI contrast agents (CA), have to be conjugated to a specific vector able to recognize the epitope of interest. Several Gd(III)-chelates can be chemically linked to the same binding vector in order to deliver multiple copies of the CA (multimers) in a single targeting event thus increasing the sensitivity of the molecular probe...
February 22, 2018: Bioconjugate Chemistry
Yuji Mahara, Junya Ohyama, Kyoichi Sawabe, Atsushi Satsuma
Supported bimetallic catalysts have been studied because of their enhanced catalytic properties due to metal-metal interactions compared with monometallic catalysts. We focused on galvanic deposition (GD) as a bimetallization method, which achieves well-defined metal-metal interfaces by exchanging heterogeneous metals with different ionisation tendencies. We have developed Ni@Ag/SiO2 catalysts for CO oxidation, Co@Ru/Al2 O3 catalysts for automotive three-way reactions and Pd-Co/Al2 O3 catalysts for methane combustion by using the GD method...
February 22, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Dmitry Averyanov, Oleg Parfenov, Andrei Tokmachev, Igor Karateev, Oleg Kondratev, Alexander Taldenkov, Mikhail Platunov, Fabrice Wilhelm, A Rogalev, Vyacheslav G Storchak
Metal-insulator transitions (MITs) offer new functionalities for nanoelectronics. However, ongoing attempts to control the resistivity by external stimuli are hindered by strong coupling of spin, charge, orbital and lattice degrees of freedom. This difficulty presents a quest for materials which exhibit MIT caused by a single degree of freedom. In the archetypal ferromagnetic semiconductor EuO, magnetic orders dominate the MIT. Here we report a new approach to take doping under control in this material on the nanoscale: formation of oxygen vacancies is strongly suppressed to exhibit the highest MIT resistivity jump and magnetoresistance among thin films...
February 22, 2018: Nanotechnology
A J Valkama, J Meinilä, S Koivusalo, J Lindström, K Rönö, B Stach-Lempinen, H Kautiainen, J G Eriksson
BACKGROUND: Healthy diets before and during pregnancy have been suggested to reduce the risk of gestational diabetes (GDM). Several lifestyle intervention studies for pregnant women have reported dietary improvements after counselling. However, evidence concerning the effect of counselling initiated before pregnancy on diets is limited. METHODS: This randomised controlled study explored whether pre-pregnancy lifestyle counselling influenced food intakes, as well as whether changes in food intakes were associated with GDM...
February 22, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Reem Abdwani, Laila Al Shaqsi, Ibrahim Al-Zakwani
Objectives: Systemic lupus erythematous (SLE) is a chronic autoimmune disease that affects women primarily of childbearing age. The objective of this study was to determine the neonatal and maternal outcomes of pregnancies in SLE patients compared to pregnancies in healthy controls. Methods: We conducted a retrospective cohort study in a tertiary care hospital in Oman between January 2007 and December 2013. We analyzed 147 pregnancies and compared 56 (38.0%) pregnancies in women with SLE with 91 (61...
January 2018: Oman Medical Journal
Dong Peng, Lei Yin, Peng Hu, Bao Li, Zhong-Wen Ouyang, Gui-Lin Zhuang, Zhenxing Wang
By utilizing a preselected functional ligand produced by 1H-imidazole-4,5-dicarboxylic acid, three isostructural lanthanide coordination polymers (CPs), denoted as {[Ln2 (OH)2 (L)2 ]·(DMF)·(H2 O)4 }n (Ln = Gd (1), Eu (2), Dy (3); L = 1-(4-carboxybenzyl)imidazole-4-carboxylic acid), containing a 1D infinite [Ln4 (OH)4 ] subchain have been successfully constructed. The highly connected mode between the multifunctional ligand and 1D building units is responsible for the exceptional chemical stability of three lanthanide CPs...
February 21, 2018: Inorganic Chemistry
Jiraporn Ousingsawat, Podchanart Wanitchakool, Rainer Schreiber, Karl Kunzelmann
Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+ activated phospholipid scramblase and ion channel TMEM16F has been shown earlier to control cellular effects downstream of purinergic P2X7 receptors that ultimately lead to cell death. As pyroptotic cell death is accompanied by an increases in intracellular Ca2+ , we asked whether TMEM16F is activated during pyroptosis...
February 20, 2018: Cell Death & Disease
C-J Ingelmann, M Witzig, J Möhring, M Schollenberger, I Kühn, M Rodehutscord
This study aimed to investigate the effect of phytase and a combination of phytase and xylanase on the prececal phosphorus digestibility (pcdP) of wheat-based diets in turkeys. A low-P basal diet (BD) based on cornstarch and soybean meal, and 2 diets containing 43% of different wheat genotypes (genotype diets GD6 or GD7) were fed to turkeys from 20 to 27 d of age. Diets were fed either without enzyme supplementation or supplemented with phytase (500 FTU/kg) or a combination of phytase and xylanase (16,000 BXU/kg)...
February 15, 2018: Poultry Science
Iva Sklempe Kokic, Marina Ivanisevic, Tomislav Kokic, Bostjan Simunic, Rado Pisot
Research on the acute responses to exercise in pregnancy is scarce, especially for women affected by gestational diabetes mellitus (GDM). The aim of this study was to investigate responses to a single bout of exercise performed multiple times throughout the pregnacy in women diagnosed with GDM. Data from 18 pregnant women (aged: 32.8 ± 3.8) diagnosed with GDM, treated with diet only, were analysed. Participants' pre-pregnancy body mass index was 24.4 ± 4.9 kg/m2 , 50% of them were nullipaorus, and 50% of the sample regularly exercised before the pregnany...
February 20, 2018: Scandinavian Journal of Medicine & Science in Sports
I V Yang, W Zhang, E J Davidson, T E Fingerlin, K Kechris, D Dabelea
AIMS: To identify gestational diabetes mellitus exposure-associated DNA methylation changes and assess whether such changes are also associated with adiposity-related outcomes. METHODS: We performed an epigenome-wide association analysis, using Illumina 450k methylation arrays, on whole blood collected, on average, at 10.5 years of age from 81 gestational diabetes-exposed and 81 unexposed offspring enrolled in the EPOCH (Exploring Perinatal Outcomes in Children) study, and on the cord blood of 31 gestational diabetes-exposed and 64 unexposed offspring enrolled in our own 'Healthy Start' cohort...
February 20, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Dilek Dilli, Nazan Neslihan Doğan, Mehmet Şah İpek, Yunus Çavuş, Serdar Ceylaner, Haldun Doğan, Arzu Dursun, Tuncay Küçüközkan, Ayşegül Zenciroğlu
BACKGROUND: To evaluate the effects of maternal fish oil supplementation in women with gestational diabetes mellitus (GDM) on birthweight and DNA methylation at insulin like growth factor-1 (IGF-1) gene in their offspring. METHODS: Randomized controlled trial. A total of 120 women with GDM were randomized to one of the two groups between 24 and 28 weeks of the pregnancy: Group 1 (n = 52) received fish oil liquid softgel (Ocean plus®) and Group 2 (Placebo) (n = 68) sunflower oil liquid softgel...
February 2018: Clinical Nutrition ESPEN
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