Vijith Vijayan, Hao Yan, Juliane K Lohmeyer, Kaylin A Prentiss, Rachana V Patil, Giulia Barbarito, Ivan Lopez, Aly Elezaby, Kolten Peterson, Jeanette Baker, Nicolai P Ostberg, Alice Bertaina, Robert S Negrin, Daria Mochly-Rosen, Kenneth I Weinberg, Bereketeab Haileselassie
Despite therapeutic advancements, GVHD is a major complication of HSCT. In current models of GVHD, tissue injury induced by cytotoxic conditioning regimens, along with translocation of microbes expressing Pathogen Associated Molecular Patterns (PAMPs), result in activation of host antigen-presenting cells (APC) to stimulate alloreactive donor T lymphocytes. Recent studies have demonstrated that in many pathologic states, tissue injury results in the release of mitochondria from the cytoplasm to the extracellular space...
May 3, 2024: Blood Advances