keyword
MENU ▼
Read by QxMD icon Read
search

Mwm

keyword
https://www.readbyqxmd.com/read/27917270/effect-of-creatine-supplementation-on-cognitive-performance-and-apoptosis-in-a-rat-model-of-amyloid-beta-induced-alzheimer-s-disease
#1
Malek Alimohammadi-Kamalabadi, Mohammadreza Eshraghian, Mohammad-Reza Zarindast, Abbas Aliaghaei, Hamideh Pishva
OBJECTIVES: Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS: Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group went through no surgical or dietary intervention. At the 4th week of study Sham group had a hippocampal normal saline injection, while Aβ and AβCr groups had an β-amyloid injection in the hippocampus...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27904421/cannabis-induced-moto-cognitive-dysfunction-in-wistar-rats-ameliorative-efficacy-of-nigella-sativa
#2
Aminu Imam, Moyosore Saliu Ajao, Abdulbasit Amin, Wahab Imam Abdulmajeed, Abdulmumin Ibrahim, Olayemi Joseph Olajide, Musa Iyiola Ajibola, Abdulmusawir Alli-Oluwafuyi, Wasiu Gbolahan Balogun
BACKGROUND: Cannabis is a widely used illicit drug with various threats of personality syndrome, and Nigella sativa has been widely implicated as having therapeutic efficacy in many neurological diseases. The present study investigates the ameliorative efficacy of Nigella sativa oil (NSO) on cannabis-induced moto-cognitive defects. METHODS: Scopolamine (1 mg/kg i.p.) was given to induce dementia as a standard base line for cannabis (20 mg/kg)-induced cognitive impairment, followed by an oral administration of NSO (1 ml/kg) for 14 consecutive days...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27887996/effects-of-erythropoietin-on-neonatal-hypoxia-ischemia-brain-injury-in-rat-model
#3
Qing Ren, Zhong-Hui Jiang, Xing-Fang Zhang, Qiao-Zhi Yang
BACKGROUND: Hypoxic-ischemic (HI) injury to the developing brain remains a major cause of morbidity. To date, few therapeutic strategies could provide complete neuroprotection. Erythropoietin (EPO) has been shown to be beneficial in several models of neonatal HI. This study examines the effect of treatment with erythropoietin on postnatal day 2 (P2) rats introduced with HI injury. METHOD: Rats at P2 were randomized into four groups: sham, bilateral carotid artery occlusion (BCAO), BCAO + early EPO, and BCAO + late EPO groups...
November 23, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27885411/scopolamine-disrupts-place-navigation-in-rats-and-humans-a-translational-validation-of-the-hidden-goal-task-in-the-morris-water-maze-and-a-real-maze-for-humans
#4
Jan Laczó, Hana Markova, Veronika Lobellova, Ivana Gazova, Martina Parizkova, Jiri Cerman, Tereza Nekovarova, Karel Vales, Sylva Klovrzova, John Harrison, Manfred Windisch, Kamil Vlcek, Jan Svoboda, Jakub Hort, Ales Stuchlik
RATIONALE: Development of new drugs for treatment of Alzheimer's disease (AD) requires valid paradigms for testing their efficacy and sensitive tests validated in translational research. OBJECTIVES: We present validation of a place-navigation task, a Hidden Goal Task (HGT) based on the Morris water maze (MWM), in comparable animal and human protocols. METHODS: We used scopolamine to model cognitive dysfunction similar to that seen in AD and donepezil, a symptomatic medication for AD, to assess its potential reversible effect on this scopolamine-induced cognitive dysfunction...
November 24, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27882565/tanshinone-iia-attenuates-a%C3%AE-25-35-induced-spatial-memory-impairment-via-upregulating-receptors-for-activated-c-kinase1-and-inhibiting-autophagy-in-hippocampus
#5
Jiejun Zhu, Shiping Liao, Liming Zhou, Lihong Wan
OBJECTIVES: Tanshinone IIA (Tan IIA) may exert significant protective effects against the neurotoxicity induced by β-amyloid protein (Aβ). This study was designed to investigate the possible neuroprotective mechanism of Tan IIA on Aβ25-35 -induced spatial memory impairment in mice. METHODS: After 3 weeks of preventive treatment (Tan IIA or oil), all male Kunming mice were subjected to Aβ25-35 (10 μl, intracerebroventricularly (i.c.v.)) to establish the spatial memory impairment model...
November 23, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27882447/neonatal-repeated-exposure-to-isoflurane-not-sevoflurane-in-mice-reversibly-impaired-spatial-cognition-at-juvenile-age
#6
Jianhui Liu, Yanhong Zhao, Junjun Yang, Xiaoqing Zhang, Wei Zhang, Peijun Wang
Inhalation anesthetics facilitate surgical procedures in millions of children each year. However, animal studies demonstrate that exposure to the inhalation anesthetic isoflurane may cause neuronal cell death in developing brains. The long-term cytotoxic effects of sevoflurane, the most popular pediatric anesthetic, have not been compared with isoflurane. Thus, this study was designed to compare the effects of equipotent doses of these two anesthetics on neonatal long-term neurotoxicity. Postnatal 7-day-old (P7) C57/BL male mice were exposed to 1...
November 24, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27876636/concordance-between-veterans-self-report-and-documentation-of-surrogate-decision-makers-implications-for-quality-measurement
#7
Kimberly K Garner, Patricia Dubbert, Shelly Lensing, Dennis H Sullivan
CONTEXT: The Measuring What Matters (MWM) initiative of the American Academy of Hospice and Palliative Medicine and the Hospice and Palliative Nurses Association identified documentation of a surrogate decision maker as one of the top 10 quality indicators in the acute hospital and hospice settings. OBJECTIVES: To better understand the potential implementation of this MWM quality measure #8, Documentation of Surrogate in outpatient primary care settings by describing primary care patients' self-reported identification and documentation of a surrogate decision maker...
November 19, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27834613/patient-outcomes-utilizing-the-mulligan-concept-of-mwm-to-treat-intercollegiate-patients-diagnosed-with-lateral-ankle-sprain-an-a-priori-case-series
#8
James M May, Alan Nasypany, Julie Paolino, Russell Baker, Jeffrey Seegmiller
CONTEXT: While the incidence and re-injury rates of lateral ankle sprain (LAS) continue to persist at high rates across many sporting activities, further exploration of assessment and treatment beyond the traditional ligamentous and strength/proprioceptive model is warranted. Further, assessing and treating both arthrokinematic and osteokinematic changes associated with LAS can provide insight into a more diverse approach to treating ankle pathology. OBJECTIVE: To examine the clinical use of the Mulligan Concept MWM while treating patients diagnosed with an acute grade I or II LAS through authentic patient care...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27834333/effect-of-lamotrigine-levetiracetam-topiramate-on-neurobehavioural-parameters-oxidative-stress-in-comparison-with-valproate-in-rats
#9
Sudhir Chandra Sarangi, Ashish Kumar Kakkar, Ritesh Kumar, Yogendra Kumar Gupta
BACKGROUND & OBJECTIVES: Though newer antiepileptic drugs are considered safer than conventional antiepileptics, the effects of lamotrigine, levetiracetam and topiramate on neurobehavioural functions are yet to be established. This study evaluated neurobehavioural parameters and oxidative stress markers in brain tissue of rats treated with lamotrigine, levetiracetam and topiramate compared to sodium valproate . METHODS: Five groups of male Wistar rats were treated respectively with normal saline (control), sodium valproate (370 mg/kg), lamotrigine (50 mg/kg), levetiracetam (310 mg/kg) and topiramate (100 mg/kg) for 45 days...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27834136/pharmacological-evaluation-of-the-recuperative-effect-of-morusin-against-aluminum-trichloride-alcl3-induced-memory-impairment-in-rats
#10
Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua, Madhu Ashwathanarayana
BACKGROUND: Elevation in brain levels of aluminium can be neurotoxic and can cause learning and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The current study was intended to discover the recuperative effect of morusin against aluminium trichloride (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action. METHODS: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals...
November 10, 2016: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27829866/electroacupuncture-ameliorates-learning-and-memory-and-improves-synaptic-plasticity-via-activation-of-the-pka-creb-signaling-pathway-in-cerebral-hypoperfusion
#11
Cai-Xia Zheng, Min Lu, Ya-Bi Guo, Feng-Xia Zhang, Hua Liu, Feng Guo, Xiao-Lin Huang, Xiao-Hua Han
Electroacupuncture (EA) has shown protective effects on cognitive decline. However, the underlying molecular mechanisms are ill-understood. The present study was undertaken to determine whether the cognitive function was ameliorated in cerebral hypoperfusion rats following EA and to investigate the role of PKA/CREB pathway. We used a rat 2-vessel occlusion (2VO) model and delivered EA at Baihui (GV20) and Dazhui (GV14) acupoints. Morris water maze (MWM) task, electrophysiological recording, Golgi silver stain, Nissl stain, Western blot, and real-time PCR were employed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27829501/immediate-effects-of-mobilization-with-movement-vs-sham-technique-on-range-of-motion-strength-and-function-in-patients-with-shoulder-impingement-syndrome-randomized-clinical-trial
#12
João Flávio Guimarães, Tania Fátima Salvini, Aristides Leite Siqueira, Ivana Leão Ribeiro, Paula Rezende Camargo, Francisco Alburquerque-Sendín
OBJECTIVE: The purpose of this study was to compare the immediate effects of mobilization with movement (MWM) with sham technique on range of motion (ROM), muscle strength, and function in patients with shoulder impingement syndrome. METHODS: A randomized clinical study was performed. Participants (mean age ± standard deviation, 31 ± 8 years; 56% women) were divided into 2 groups: group 1 (n = 14), which received the MWM technique in the first 4 sessions and the sham technique in the last 4 sessions; and group 2 (n = 13), which was treated with the opposite order of treatment conditions described for group 1...
November 6, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27819338/quinolinic-acid-injection-in-mouse-medial-prefrontal-cortex-affects-reversal-learning-abilities-cortical-connectivity-and-hippocampal-synaptic-plasticity
#13
Amira Latif-Hernandez, Disha Shah, Tariq Ahmed, Adrian C Lo, Zsuzsanna Callaerts-Vegh, Annemie Van der Linden, Detlef Balschun, Rudi D'Hooge
Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain disease. Complementary techniques were combined to examine the consequences of QA injection into medial prefrontal cortex (mPFC) of C57BL6 mice. In accordance with the NMDAR-mediated synapto- and neurotoxic action of QA, we found an initial increase in excitability and an augmentation of hippocampal long-term potentiation, converting within two weeks into a reduction and impairment, respectively, of these processes...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27810570/adherence-to-measuring-what-matters-items-when-caring-for-patients-with-hematologic-malignancies-vs-solid-tumors
#14
Thomas W LeBlanc, Christine Ritchie, Fred Friedman, Janet Bull, Jean S Kutner, Kimberly S Johnson, Arif H Kamal
CONTEXT: Measuring What Matters (MWM) prioritizes quality measures in palliative care practice. Hematologic malignancy patients are less likely to access palliative care, yet little is known about their unique needs. Differences in MWM adherence may highlight opportunities to improve palliative care in hematology. OBJECTIVES: To assess adherence to MWM measures by palliative care clinicians caring for patients with hematologic malignancies, compared to those with solid tumors...
October 31, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27810377/preventive-effect-of-genetic-knockdown-and-pharmacological-blockade-of-cyslt1r-on-lipopolysaccharide-lps-induced-memory-deficit-and-neurotoxicity-in-vivo
#15
Fang Chen, Arijit Ghosh, Feng Wu, Susu Tang, Mei Hu, Hongbin Sun, Lingyi Kong, Hao Hong
Previously we reported that cysteinyl leukotrienes (Cys-LTs) and the type 1 receptor for Cys-LTs (CysLT1R) are related to amyloid β (Aβ)-induced neurotoxicity. The aim of the current study was to find out the role of CysLT1R on lipopolysaccharide (LPS)-induced cognitive deficit and neurotoxicity. shRNA-mediated knockdown or pharmacological blockade (by pranlukast) of CysLT1R were performed in ICR mice for 21days prior to systemic infusion of LPS. From day 22, LPS was administered for 7days and then a set of behavioral, histopathological and biochemical tests were employed to test memory, neuroinflammation and apoptotic responses in the mouse hippocampus...
November 1, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27806662/galantamine-and-environmental-enrichment-enhance-cognitive-recovery-after-experimental-traumatic-brain-injury-but-do-not-confer-additional-benefits-when-combined
#16
Patricia B de la Tremblaye, Corina O Bondi, Naima Lajud, Jeffrey P Cheng, Hannah Radabaugh, Anthony E Kline
Environmental enrichment (EE) enhances cognition after traumatic brain injury (TBI). Galantamine (GAL) is an acetylcholinesterase inhibitor that may also promote benefits. Hence, the aims of this study were to assess the efficacy of GAL alone (standard (STD) housing) and in combination with EE in adult male rats after TBI. The hypothesis was that both therapies would confer motor, cognitive, and histological benefits when provided singly, but their combination would be more efficacious. Anesthetized rats received a controlled cortical impact or sham injury and then were randomly assigned to receive GAL (1, 2, or 3 mg/kg; i...
November 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27803783/protective-effect-of-%C3%AE-terpineol-against-impairment-of-hippocampal-synaptic-plasticity-and-spatial-memory-following-transient-cerebral-ischemia-in-rats
#17
Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva Ghafghazi
OBJECTIVES: Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-terpineol against memory impairment following cerebral ischemia in rats. MATERIALS AND METHODS: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27794490/the-effects-of-captopril-on-lipopolysaccharide-induced-learning-and-memory-impairments-and-the-brain-cytokine-levels-and-oxidative-damage-in-rats
#18
Azam Abareshi, Mahmoud Hosseini, Farimah Beheshti, Fatemeh Norouzi, Majid Khazaei, Hamid Reza Sadeghnia, Mohammad Hossein Boskabady, Mohammad Naser Shafei, Akbar Anaeigoudari
AIM: Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS: The rats were divided and treated : Ciobica et al. (2009) saline (Control), Wright and Harding (2004) LPS (1mg/kg), McKinley et al. (2003), Lenkei et al...
October 26, 2016: Life Sciences
https://www.readbyqxmd.com/read/27790463/comparison-between-the-effect-of-cow-ghee-and-butter-on-memory-and-lipid-profile-of-wistar-rats
#19
Yogita Surendra Karandikar, Akshata Sanjay Bansude, Eesha Ajit Angadi
INTRODUCTION: The traditional texts designate Cow Ghee as Medhya Rasayana, beneficial for mental alertness and memory. There has been concern about increased risk of cardiovascular disease due to its high percentage of saturated fatty acids in ghee. Amongst all edible fats, nutrition composition of cow ghee and butter is comparatively similar. Hence we had planned a study to assess effect of cow ghee on memory and lipid profile. AIM: So the aim of this study is to assess the effect of cow ghee on memory and lipid profile...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27781114/coenzyme-q10-ameliorates-trimethyltin-chloride-neurotoxicity-in-experimental-model-of-injury-in-dentate-gyrus-of-hippocampus-a-histopathological-and-behavioral-study
#20
Mohammad Hassan Sakhaie, Mansoureh Soleimani, Vahid Pirhajati, Sara Soleimani Asl, Zahra Madjd, Mehdi Mehdizadeh
BACKGROUND: Coenzyme Q10 has antioxidative and free radical scavenging effects. CoQ10 supplementation is known to have neuroprotective effects in some neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. OBJECTIVES: The aim of this study was to evaluate both histopathologic and behavioral whether Coenzyme Q10 is protective against trimethyltin chloride (TMT) induced hippocampal damage. MATERIALS AND METHODS: This was an experimental study...
August 2016: Iranian Red Crescent Medical Journal
keyword
keyword
87234
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"