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https://www.readbyqxmd.com/read/28096851/acetylcholinesterase-inhibitor-improves-learning-and-memory-impairment-induced-by-toxoplasma-gondii-infection
#1
Hossein Mahmoudvand, Vahid Sheibani, Hossein Keshavarz, Saeedeh Shojaee, Khadijeh Esmaeelpour, Naser Ziaali
BACKGROUND: Here, we established the mouse models of chronic toxoplasmosis by T. gondii Tehran strain to provide a good understanding about defining the possible association between T. gondii exposure and learning and memory impairments. Moreover, as secondary objective of the present study, we hypothesized whether administration of an acetylcholinesterase (AChE) inhibitor could reduce learning and memory impairments induced by T. gondii infection. METHODS: Twenty-four male BALB/c mice were used to establishment of latent toxoplasmosis...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28093570/vitamin-d-administration-cognitive-function-bbb-permeability-and-neuro-inflammatory-factors-in-high-fat-diet-induced-obese-rats
#2
G Hajiluian, G Nameni, P Shahabi, M Mesgari-Abbasi, S Sadigh-Eteghad, M A Farhangi
OBJECTIVES: The purpose of this research is to investigate the effects of vitamin D administration on cognitive function, nuclear factor Kappa-B (NF-kB), brain derived neurotrophic factor (BDNF) concentration in the hippocampus and blood-brain barrier (BBB) permeability in high-fat diet (HFD) induced obese rats. METHODS: Male Wistar rats were fed either a control diet or HFD for 16 weeks (n=20); then each group was randomized into two subgroups supplemented orally with 500 IU/kg vitamin D for 5 weeks...
January 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28087280/increased-homocysteine-levels-impair-reference-memory-and-reduce-cortical-levels-of-acetylcholine-in-a-mouse-model-of-vascular-cognitive-impairment
#3
Kevin Dam, Martina Füchtemeier, Tracy D Farr, Philipp Boehm-Sturm, Marco Foddis, Ulrich Dirnagl, Olga Malysheva, Marie A Caudill, Nafisa M Jadavji
Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic (methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levels of homocysteine. Clinical studies have shown that elevated levels of homocysteine (Hcy) may be associated with the development of dementia, however this link remains unclear. The purpose of this study was to evaluate the impact of increased Hcy levels on a mouse model of vascular cognitive impairment (VCI) produced by chronic hypoperfusion...
January 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28080183/palliative-care-scorecard
#4
Sheri Kittelson, Read Pierce, Jeanie Youngwerth
BACKGROUND: In response to poor healthcare quality outcomes and rising costs, healthcare reform triple aim has increased requirements for providers to demonstrate value to payers, partners, and the public. OBJECTIVE: Electronically automating measurement of the meaningful impact of palliative care (PC) programs on clinical, operational, and financial systems over time is imperative to the success of the field and the goal of development of this automated PC scorecard...
January 12, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28078612/ameliorative-effect-of-ginsenoside-rg1-on-lipopolysaccharide-induced-cognitive-impairment-role-of-cholinergic-system
#5
Yang Jin, Jian Peng, Xiaona Wang, Dong Zhang, Tianyin Wang
Bacterial endotoxin lipopolysaccharide (LPS) can induce systemic inflammation, and therefore disrupt learning and memory processes. Ginsenoside Rg1, a major bioactive component of ginseng, is shown to greatly improve cognitive function. The present study was designed to further investigate whether administration of ginsenoside Rg1 can ameliorate LPS-induced cognitive impairment in the Y-maze and Morris water maze (MWM) task, and to explore the underlying mechanisms. Results showed that exposure to LPS (500 μg/kg) significantly impaired working and spatial memory and that repeated treatment with ginsenoside Rg1 (200 mg/kg/day, for 30 days) could effectively alleviate the LPS-induced cognitive decline as indicated by increased working and spatial memory in the Y-maze and MWM tests...
January 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28077004/endoplasmic-reticulum-stress-modulation-as-a-target-for-ameliorating-effects-of-blast-induced-traumatic-brain-injury
#6
Brandon Peter Lucke-Wold, Aric Logsdon, Ryan C Turner, Jason D Huber, Charles L Rosen
Blast traumatic brain injury (bTBI) has been shown to contribute to progressive neurodegenerative disease. Recent evidence suggests that endoplasmic reticulum (ER) stress is a mechanistic link between acute neurotrauma and progressive tauopathy. We propose that ER stress contributes to extensive behavioral changes associated with a CTE-like phenotype. Targeting ER stress is a promising option for the treatment of neurotrauma related neurodegeneration warranting investigation. Utilizing our validated and clinically relevant Sprague-Dawley blast model, we investigated a time course of mechanistic changes that occur following bTBI (50 PSI) including: ER stress activation, iron mediated toxicity, and tauopathy via western blot and immunohistochemistry...
January 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28063945/calcineurin-inhibitors-improve-memory-loss-and-neuropathological-changes-in-mouse-model-of-dementia
#7
Amit Kumar, Nirmal Singh
AIM: The present study was designed to investigate the potential of Cyclosporine (CsA) and Tacrolimus, the inhibitors of calcineurin (CaN) in cognitive deficits of mice. METHODS: Streptozotocin [STZ, 3mg/kg, injected intracerebroventricular (i.c.v.)] was used to induce memory deficits in NIH mice, while aged mice separately taken served as a natural model of dementia. Morris water maze (MWM) test was employed to evaluate learning and memory of the animals. A battery of biochemical and histopathological studies was also performed...
January 4, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28042059/operationalizing-the-measuring-what-matters-spirituality-quality-metric-in-a-population-of-hospitalized-critically-ill-patients-and-their-family-members
#8
Rebecca A Aslakson, Josephine Kweku, Malonnie Kinnison, Sarabdeep Singh, Thomas Y Crowe
CONTEXT: Measuring What Matters (MWM) quality indicators support measurement of the percentage of patients who have spiritual discussions, if desired. OBJECTIVES: To 1) determine the ease of, and barriers to, prospectively collecting MWM spirituality quality measure data and 2) further explore the importance of spirituality in a seriously ill, hospitalized population of critically ill patients and their family members. METHODS: Electronic medical record (EMR) review and cross-sectional survey of ICU patients and their family members from October-December 2015...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28035919/investigation-on-the-role-of-bdnf-in%C3%A2-the%C3%A2-benefits-of-blueberry-extracts-for-the%C3%A2-improvement-of-learning-and-memory-in%C3%A2-alzheimer-s-disease-mouse-model
#9
Long Tan, Hongpeng Yang, Wei Pang, Haiqiang Li, Wei Liu, Shoudan Sun, Nan Song, Wanqi Zhang, Yugang Jiang
BACKGROUND: Blueberry (BB) can provide a wide range of antioxidant benefits for AD. There have amounts of evidences shown that BB extracts could improve brain functions. However, the details are still unknown. OBJECTIVE: In the present study, we aimed to investigate the possible mechanism involved in the improvement of learning and memory capacity from BB extracts in AD. METHODS: APP/PS1 transgenic mice were fed BB extracts for 16 weeks. The capacity of learning and memory was assessed by Morris water maze (MWM) test, and long-term potentiation (LTP) was determined to evaluate hippocampal neuronal plasticity at the end of administration...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28032988/neuroprotective-effect-of-slm-a-novel-carbazole-based-fluorophore-on-sh-sy5y-cell-model-and-3xtg-ad-mouse-model-of-alzheimer-s-disease
#10
Xiaoli Wu, Jayasankar Kosaraju, Wei Zhou, Kin Yip Tam
Amyloid β (Aβ) peptide aggregating to form a neurotoxic plaque, leading to cognitive deficits, is believed to be one of the plausible mechanisms for Alzheimer's disease (AD). Inhibiting Aβ aggregation is supposed to offer a neuroprotective effect to ameliorate AD. A previous report has shown that SLM, a carbazole-based fluorophore, binds to Aβ to inhibit the aggregation. However, it is not entirely clear whether the inhibition of Aβ aggregation alone would lead to the anticipated neuroprotective effects...
December 29, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28028518/study-of-the-effects-of-controlled-morphine-administration-for-treatment-of-anxiety-depression-and-cognition-impairment-in-morphine-addicted-rats
#11
Majid Motaghinejad, Sulail Fatima, Sanaz Banifazl, Mohammad Yasan Bangash, Morteza Karimian
BACKGROUND: Morphine dependency usually results in undesired outcomes such as anxiety, depression, and cognitive alterations. In this study, morphine was used to manage morphine dependence-induced anxiety, depression, and learning and memory disturbances. MATERIALS AND METHODS: Forty rats were divided equally into five groups. Group 1 received saline for 21 days. Groups 2-5 were dependent by increasing administration of morphine (15-45 mg/kg) for 7 days. For the next 14 days, morphine was administered as the following regimen: Group 2: once daily; 45 mg/kg (positive controls), Group 3: the same dose with an increasing interval (6 h longer than the previous intervals each time), Group 4: the same dose with an irregular intervals (12, 24, 36 h intervals interchangeably), and Group 5: decreasing doses once daily (every time 2...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28025042/quercetin-ameliorates-chronic-unpredicted-stress-mediated-memory-dysfunction-in-male-swiss-albino-mice-by-attenuating-insulin-resistance-and-elevating-hippocampal-glut4-levels-independent-of-insulin-receptor-expression
#12
Vineet Mehta, Arun Parashar, Arun Sharma, Tiratha Raj Singh, Malairaman Udayabanu
Chronic stress is associated with impaired neuronal functioning, altered insulin signaling, and behavioral dysfunction. Quercetin has shown neuroprotective and antidiabetic effects, besides modulating cognition and insulin signaling. Therefore, in the present study, we explored whether or not quercetin ameliorates stress-mediated cognitive dysfunction and explored the underlying mechanism. Swiss albino male mice were subjected to an array of unpredicted stressors for 21days, during which 30mg/kg quercetin treatment was given orally...
December 23, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/28006940/does-effect-from-developmental-methamphetamine-exposure-on-spatial-learning-and-memory-depend-on-stage-of-neuroontogeny
#13
I Hrebíčková, M Ševčíková, K Nohejlová, R Šlamberová
Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats. Eight groups of male rats were tested in adulthood: males whose mothers were exposed to MA (5 mg/kg) or saline (SA, 1 ml/kg) during the first half of gestation period (GD 1-11), the second half of gestation period (GD 12-22) and neonatal period (PD 1-11)...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/27998753/effects-of-intra-hippocampal-microinjection-of-vitamin-b12-on-the-orofacial-pain-and-memory-impairments-induced-by-scopolamine-and-orofacial-pain-in-rats
#14
Amir Erfanparast, Esmaeal Tamaddonfard, Shaghayegh Nemati
In the present study, we investigated the effects of microinjection of vitamin B12 into the hippocampus on the orofacial pain and memory impairments induced by scopolamine and orofacial pain. In ketamine-xylazine anesthetized rats, the right and left sides of the dorsal hippocampus (CA1) were implanted with two guide cannulas. Orofacial pain was induced by subcutaneous injection of formalin (1.5%, 50μl) into the right vibrissa pad, and the durations of face rubbing were recorded at 3-min blocks for 45min. Morris water maze (MWM) was used for evaluation of learning and memory...
December 18, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27990002/cinepazide-maleate-improves-cognitive-function-and-protects-hippocampal-neurons-in-diabetic-rats-with-chronic-cerebral-hypoperfusion
#15
Yumei Li, Ting Zhang, Xiaojie Zhang, Wenying Zou, Xian Gong, Jianliang Fu
To determine the combined effect of type 2 diabetes (T2D) and chronic cerebral hypoperfusion (CCH) on learning and spatial memory, we developed a rat model of CCH by permanent occlusion of bilateral common carotid arteries (2VO) in high-fat diet (HFD)-fed rats injected with low-dose streptozotocin (STZ). Furthermore, we examined the effect of cinepazide maleate (CM) on cognitive deficits and brain damage in this rat model. Rats were maintained on HFD for 6 weeks and then injected with 35 mg/kg STZ to induce T2D...
December 17, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27973945/sevoflurane-induces-cognitive-impairments-via-the-mir-27b-limk1-signaling-pathway-in-developing-rats
#16
Yue Yu, Peihong Zhang, Jia Yan, Yuanqing Sun, Xiaoyang Wu, Siwei Xi, Lei Zhang, Yu Sun, Rong Hu, Hong Jiang
Exposure to sevoflurane in neonatal rats could induce learning deficits and abnormal social behaviors, but the specific molecular mechanism is unknown. Postnatal day-7 SD rats were treated with 3% sevoflurane plus 30% oxygen/air or 30% oxygen/air. As the rats grew, the Morris water maze (MWM) and fear conditioning tests were performed to evaluate cognitive function, while the expression of LIMK1 was analyzed by western blot. Luciferase reporter assay was performed to investigate the interaction between LIMK1 and miR-27b...
December 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27966331/boswellia-serrata-gum-resin-aqueous-extract-upregulatesbdnf-but-not-creb-expression-in-adult-male-rat-hippocampus
#17
Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
BACKGROUND/AIM: Boswellia from the family Burseraceae has been proposed for prevention of amnesia; however, the molecular mechanism by which it affects memory is not clear. To reveal the potential molecular mechanism, the effects of boswellia on the expression of two memory related genes, CREB and BDNF, were investigated. MATERIALS AND METHODS: Twenty-one male rats were randomly divided into 3 groups (n = 7): the control group received distilled water and the treatment groups received two doses of aqueous extract of Boswellia serrata gum resin (boswellia) (50 and 100 mg/kg) every day for 4 weeks...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27937042/prevention-of-hypertension-induced-vascular-dementia-by-lactobacillus-paracasei-subsp-paracasei-ntu-101-fermented-products
#18
Meng-Chun Cheng, Tzu-Ming Pan
CONTEXT: Numerous etiological studies have established positive clinical association between hypertension and vascular dementia (VaD). Lactobacillus paracasei subsp. paracasei NTU 101-fermented products have been shown to decrease vascular risk factors such as hypertension, atherosclerosis, hyperlipidemia and obesity. OBJECTIVE: This study investigated the effect of ethanol extract of Lactobacillus paracasei subsp. paracasei NTU 101-fermented products (NTU101F) in hypertension-induced VaD in rats...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27931777/effects-of-maternal-separation-on-nicotine-induced-conditioned-place-preference-and-subsequent-learning-and-memory-in-adolescent-female-rats
#19
Fatemeh Dalaveri, Nouzar Nakhaee, Khadijeh Esmaeilpour, Saeed Esmaeili Mahani, Vahid Sheibani
Adverse early life experiences can potentially increase risk for drug abuse later in life. However, little research has been conducted studying the effects of maternal separation (MS), an experimental model for early life stress, on the rewarding effects of nicotine. Cognitive function may be affected by MS. So, we also investigated whether nicotine administration affect spatial learning and memory in MS adolescent female rats. Rat pups were subjected to daily MS for 15min (MS15) or 180min (MS180) during the first 2 weeks of life or reared under normal animal facility rearing (AFR) conditions...
December 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27931146/d-cycloserine-restores-experience-dependent-neuroplasticity-after-tbi-in-the-developing-rat-brain
#20
Naomi Sulit Sta Maria, Maxine Lane Reger, Yan Cai, Mary Anne Tezheart Mercado Baquing, Floyd Buen, Aditya Ponnaluri, David Hovda, Neil G Harris, Christopher C Giza
Traumatic brain injury (TBI) in children can cause persisting cognitive and behavioral dysfunction and inevitably raises concerns about lost potential in these injured youths. Lateral fluid percussion injury (FPI) in weanling rats pathologically affects hippocampal NMDAR- and AMPAR-mediated glutamatergic neurotransmission subacutely, within the first post-injury week. FPI to weanling rats has also been shown to impair enriched-environment (EE) induced enhancement of Morris water maze (MWM) learning and memory in adulthood...
December 8, 2016: Journal of Neurotrauma
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