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https://www.readbyqxmd.com/read/28432986/the-effects-of-thymoquinone-on-hippocampal-cytokine-level-brain-oxidative-stress-status-and-memory-deficits-induced-by-lipopolysaccharide-in-rats
#1
Rahimeh Bargi, Fereshteh Asgharzadeh, Farimah Beheshti, Mahmoud Hosseini, Hamid Reza Sadeghnia, Majid Khazaei
OBJECTIVE: The study objective was to determine the protective effects of thymoquinone (TQ) on brain tissues oxidative stress status, hippocampal cytokine level, and learning and memory deficits induced by lipopolysaccharide (LPS) in rats. METHODS: Animals were randomly divided into the following groups and treated: (1) Control (saline), (2) LPS (1mg/kg i.p.), (3-5) 2, 5 or 10mg/kg TQ extract 30min before LPS injection. The treatment was started since two weeks before the behavioral experiments and continued during the behavioral tests (LPS injected 2h before each behavioral experiment)...
April 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28417263/rosuvastatin-attenuates-high-salt-and-cholesterol-diet-induced-neuroinflammation-and-cognitive-impairment-via-preventing-nuclear-factor-kappab-pathway
#2
Ibraheem Husain, Mohd Akhtar, Divya Vohora, Malik Zainul Abdin, Mohammad Islamuddin, Mohd Jawaid Akhtar, Abul Kalam Najmi
Recent attention is focused on the impact of diet on health and mental well-being. High-salt and cholesterol diet (HSCD) is known to be associated with neuroinflammation which is the predominant factor for neurodegenerative disease like Alzheimer disease (AD). In the present study, we examined the neuroprotective potential of rosuvastatin, an HMG-CoA reductase inhibitor against HSCD induced neuroinflammation and cognitive impairment. Our results demonstrated that HSCD-induced cognitive impairment as determined by Morris water maze (MWM) task...
April 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28413319/black-ginseng-enriched-chong-myung-tang-extracts-improve-spatial-learning-behavior-in-rats-and-elicit-anti-inflammatory-effects-in%C3%A2-vitro
#3
Evelyn Saba, Da-Hye Jeong, Seong-Soo Roh, Seung-Hyung Kim, Sung-Dae Kim, Hyun-Kyoung Kim, Man-Hee Rhee
BACKGROUND: Chong-Myung-Tang (CMT) extract is widely used in Korea as a traditional herbal tonic for increasing memory capacity in high-school students and also for numerous body ailments since centuries. The use of CMT to improve the learning capacity has been attributed to various plant constituents, especially black ginseng, in it. Therefore, in this study, we have first investigated whether black ginseng-enriched CMT extracts affected spatial learning using the Morris water maze (MWM) test...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28408940/laser-acupuncture-exerts-neuroprotective-effects-via-regulation-of-creb-bdnf-bcl-2-and-bax-gene-expressions-in-the-hippocampus
#4
Yeong-Chan Yun, Dongyeop Jang, Sun-Bee Yoon, Dohyeong Kim, Dong-Hee Choi, O-Sang Kwon, Yu-Mi Lee, Daehwan Youn
Acupuncture has a positive effect on cognitive deficits. However, the effects of laser acupuncture (LA) on cognitive function and its mechanisms of action are unclear. The present study aimed to evaluate the effects of LA on middle cerebral artery occlusion- (MCAO-) induced cognitive impairment and its mechanisms of action. Transient focal cerebral ischemia was modeled in adult Sprague-Dawley rats by MCAO. After LA or manual-acupuncture (MA) treatment at the GV20 and HT7 for 2 weeks, hippocampal-dependent memory was evaluated using the Morris water maze (MWM) test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28401370/the-research-on-the-relationship-of-rage-lrp-1-and-a%C3%AE-accumulation-in-the-hippocampus-prefrontal-lobe-and-amygdala-of-stz-induced-diabetic-rats
#5
Lou-Yan Ma, Yu-Lang Fei, Xiao-Ye Wang, Song-Di Wu, Jun-Hui Du, Mei Zhu, Long Jin, Ming Li, Hai-Long Li, Jia-Jia Zhai, Lu-Peng Ji, Ran-Ran Ma, Song-Fang Liu, Mo Li, Li Ma, Xiao-Rui Ma, Qiu-Min Qu, Ya-Li Lv
Diabetes mellitus (DM) has been regarded as an important risk factor for Alzheimer's disease (AD), and diabetic patients and animals have shown cognitive dysfunction. More research has shown that the amyloid-β (Aβ), which is a hallmark of AD, was found deposited in the hippocampus of diabetic rats. This Aβ accumulation is regulated by the receptor for advanced glycation end products (RAGE) and low-density lipoprotein receptor-related protein (LRP-1). However, the expression of RAGE and LRP-1 in diabetic rats is not very clear...
April 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28397041/effects-of-nourishing-liver-and-kidney-acupuncture-therapy-on-expression-of-brain-derived-neurotrophic-factor-and-synaptophysin-after-cerebral-ischemia-reperfusion-in-rats
#6
Wen-Guang Xia, Chan-Juan Zheng, Xuan Zhang, Juan Wang
The aim of the present study was to investigate the effect of "nourishing liver and kidney" acupuncture therapy on motor and cognitive deficits, and the underlying mechanism following cerebral ischemia-reperfusion (I/R) via increasing the expression of brain derived neurotrophic factor (BDNF) and synaptophysin (SYN) in the hippocampus. Healthy adult male SD rats were randomly divided into sham operation group (n=51), model group (n=51), acupuncture group (n=51) and acupuncture control group (n=51). The middle cerebral I/R model was established...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28392460/mesoporous-hydroxyapatite-as-a-carrier-of-olanzapine-for-long-acting-antidepression-treatment-in-rats-with-induced-depression
#7
Yan-Jye Shyong, Mao-Hsien Wang, Li-Wei Kuo, Chang-Fu Su, Wei-Ting Kuo, Kuo-Chi Chang, Feng-Huei Lin
An antidepressant carrier, mesoporous hydroxyapatite olanzapine (mesoHAP-OLZ), was designed to maintain 3weeks of constant medication release. The carrier was intramuscularly (IM) injected, where cellular activity played a role in achieving the goal of constant release. The efficiency of the treatment was evaluated from 3 perspectives in in vivo studies: locomotor activities, biomarkers, and learning and memory ability. MesoHAP-OLZ can increase the locomotor activity in rats with induced depression determined by open field test (OFT) and forced swim test (FST)...
April 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28390198/long-term-kinetics-of-immunologic-components-and-neurological-deficits-in-rats-following-repetitive-mild-traumatic-brain-injury
#8
Ruojing Bai, Huabin Gao, Zhaoli Han, Xintong Ge, Shan Huang, Fanglian Chen, Ping Lei
BACKGROUND Despite growing awareness of repetitive mild traumatic brain injury (rmTBI), understanding of the involvement of long-term kinetics of immunologic components in the central and peripheral immune system took part remains incomplete. The present study aimed to provide a quantitative assay for certain immune system parameters in rmTBI rats. MATERIAL AND METHODS Neurological functions were assessed by modified Neurological Severity Score (mNSS) and Morris Water Maze (MWM), immunologic components from brain and peripheral blood were analyzed by flow cytometry (FCM), and concentrations of inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were measure by enzyme-linked immunosorbent assay (ELISA)...
April 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28388845/energy-dissipation-in-monolayer-mos2-electronics
#9
Eilam Yalon, Connor J McClellan, Kirby K H Smithe, Miguel Munoz-Rojo, Runjie Lily Xu, Saurabh V Suryavanshi, Alex J Gabourie, Christopher M Neumann, Feng Xiong, Amir B Farimani, Eric Pop
The advancement of nanoscale electronics has been limited by energy dissipation challenges for over a decade. Such limitations could be particularly severe for two-dimensional (2D) semiconductors integrated with flexible substrates or multi-layered processors, both being critical thermal bottlenecks. To shed light into fundamental aspects of this problem, here we report the first direct measurement of spatially resolved temperature in functioning 2D monolayer MoS2 transistors. Using Raman thermometry we simultaneously obtain tempera-ture maps of the device channel and its substrate...
April 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28386360/neuroprotective-effect-of-mir-665-against-sevoflurane-anesthesia-induced-cognitive-dysfunction-in-rats-through-pi3k-akt-signaling-pathway-by-targeting-insulin-like-growth-factor-2
#10
Xihua Lu, Shuaiguo Lv, Yan Mi, Lei Wang, Gensheng Wang
The aim of this study was to investigate the in vivo and in vitro effects of miR-665 on sevoflurane anesthesia-induced cognitive dysfunction. SH-SY5Y cells and male SD rats were treated with sevoflurane to simulate anesthesia-induced cognitive dysfunction. The cells and rats both were transfected with a miR-665 mimic, inhibitor, scramble, IGF-2 siRNA, or treated with P13K/Akt inhibitor LY294002. The cell apoptosis, autophagy, growth related proteins, and mRNA levels were measured using different methods. The motor performance was assessed using the Morris water maze (MWM) test...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28386162/neuroprotective-and-antiamnesic-effects-of-mitragyna-inermis-willd-rubiaceae-on-scopolamine-induced-memory-impairment-in-mice
#11
David Bougolla Pahaye, Elisabeth Ngo Bum, Germain Sotoing Taïwé, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Fleur Clarisse Okomolo Moto, Nadège Kouemou, Stephanie Jacqueline Kameni Njapdounke, Gisele Nkantchoua, Antoine Kandeda, Jean Pierre Omam Omam, Veronique Mairaira, Josiane Lucie Ojong
Aim. To assess memory improvement and neuroprotective and antioxidant effects of Mitragyna inermis (M. inermis) leaf decoction on the central nervous system. Methodology. Leaf decoction of M. inermis was tested on learning and memory in normal and scopolamine-induced cognitive impairment in mice using memory behavioral tests such as the Morris water maze, object recognition task, and elevated plus maze. Oxidative stress enzymes-catalase, superoxide dismutase, and the thiobarbituric acid reactive substance, a product of lipid peroxidation-were quantified...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28382596/liraglutide-improves-water-maze-learning-and-memory-performance-while-reduces-hyperphosphorylation-of-tau-and-neurofilaments-in-app-ps1-tau-triple-transgenic-mice
#12
Shuyi Chen, Jie Sun, Gang Zhao, Ai Guo, Yanlin Chen, Rongxia Fu, Yanqiu Deng
The purpose of this study was to explore how liraglutide affects AD-like pathology and cognitive function in APP/PS1/Tau triple transgenic (3 × Tg) Alzheimer disease (AD) model mice. Male 3 × Tg mice and C57BL/6 J mice were treated for 8 weeks with liraglutide (300 μg/kg/day, subcutaneous injection) or saline. Levels of phosphorylated tau, neurofilaments (NFs), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in brain tissues were assessed with western blots. Fluoro-Jade-B labeling were applied to detect pathological changes...
April 6, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28379219/effect-of-combined-administration-of-aripiprazole-and-fluoxetine-on-cognitive-functions-in-female-rats-exposed-to-ethyl-alcohol
#13
Krzysztof Kus, Piotr Ratajczak, Natasza Czaja, Tomasz Zaprutko, Elżbieta Nowakowska
Alcoholism is a chronic and recurrent disease. The studies on ethyl alcohol show a progressive deterioration of cognitive functions (motor hyperactivity, operating memory). The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol. Female Wistar rats were studied in the Morris Water Maze (MWM) and locomotor activity test. Rats undergoing the MWM and locomotor activity test were injected with saline on day 1, 7, 14 and 21 of testing...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28366951/effects-of-benzo-a-pyrene-exposure-on-the-atpase-activity-and-calcium-concentration-in-the-hippocampus-of-neonatal-rats
#14
Kai Yang, Chengzhi Chen, Shuqun Cheng, Xianqing Cao, Baijie Tu
OBJECTIVES: To investigate whether postnatal benzo(a)pyrene (B(a)P) exposure caused the impairments on the process of neurodevelopment and the alteration in the calcium medium in the neonatal rats. MATERIAL AND METHODS: Eighty neonatal Sprague Dawley (SD) rats were randomly divided into 5 groups (untreated control group, vehicle group, 0.02 mg/kg, 0.2 mg/kg and 2 mg/kg B(a)P-exposed group). Rats were treated with B(a)P by the intragastric administration from postnatal day (PND) 4 to 25...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28359886/sex-differences-in-the-strategies-of-spatial-learning-in-prenatally-exposed-rats-treated-with-various-drugs-in-adulthood
#15
Eva Macúchová, Kateryna Nohejlová, Mária Ševčíková, Ivana Hrebíčková, Romana Šlamberová
In the present study we investigated the sex differences in the effect of adult long-term drug treatment on cognitive functions of Wistar rats, which were prenatally exposed to MA (5mg/kg) or saline. Cognitive functions were tested as an ability of spatial learning in the Morris Water Maze (MWM), which consisted of three types of tests: "Place Navigation Test"; "Probe Test", and "Memory Recall Test". Adult animals were injected daily, after completion of the last trial, either with saline or cocaine (COC; 5mg/kg), MDMA (3,4-methylenedioxy-methamphetamine; 5mg/kg), morphine (MOR; 5mg/kg), or delta-9-tetrahydrocannabinol (THC; 2mg/kg)...
March 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28358909/amelioration-of-cognitive-impairments-in-appswe-ps1de9-mice-is-associated-with-metabolites-alteration-induced-by-total-salvianolic-acid
#16
Li Shen, Bing Han, Yuan Geng, Jinhua Wang, Zhengmin Wang, Mingwei Wang
PURPOSE: Total salvianolic acid (TSA) is extracted from salvia miltiorrhiza; however, to date, there has been limited characterization of its effects on metabolites in Alzheimer's disease model-APPswe/PS1dE9 mice. The main objective of this study was to investigate the metabolic changes in 7-month-old APPswe/PS1dE9 mice treated with TSA, which protects against learning and memory impairment. METHODS: APPswe/PS1dE9 mice were treated with TSA (30 mg/kg·d and 60 mg/kg·d, i...
2017: PloS One
https://www.readbyqxmd.com/read/28352309/asiaticoside-ameliorates-%C3%AE-amyloid-induced-learning-and-memory-deficits-in-rats-by-inhibiting-mitochondrial-apoptosis-and-reducing-inflammatory-factors
#17
Zhuo Zhang, Xiaobin Li, Duo Li, Mao Luo, Yongjie Li, Li Song, Xian Jiang
The present study aimed to investigate the effects of asiaticoside (AS) on the pathology and associated mechanisms of β-amyloid (Aβ)-induced Alzheimer's disease (AD) in rats. An AD rat model was established by lateral intracerebroventricular injection of Aβ 1-42 oligomers. Learning and memory function were evaluated by Morris water maze (MWM) test. In addition, hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), immunohistochemistry, ELISA and western blot analysis were performed to evaluate the disease pathogenesis...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28350374/energy-efficiency-of-d2d-multi-user-cooperation
#18
Zufan Zhang, Lu Wang, Jie Zhang
The Device-to-Device (D2D) communication system is an important part of heterogeneous networks. It has great potential to improve spectrum efficiency, throughput and energy efficiency cooperation of multiple D2D users with the advantage of direct communication. When cooperating, D2D users expend extraordinary energy to relay data to other D2D users. Hence, the remaining energy of D2D users determines the life of the system. This paper proposes a cooperation scheme for multiple D2D users who reuse the orthogonal spectrum and are interested in the same data by aiming to solve the energy problem of D2D users...
March 28, 2017: Sensors
https://www.readbyqxmd.com/read/28349041/influence-of-expectations-plus-mobilization-with-movement-in-patient-with-lateral-epicondylalgia-a-pilot-randomized-controlled-trial
#19
Francisco Vicente Martínez-Cervera, Theodor Emanuel Olteanu, Alfonso Gil-Martínez, Belén Díaz-Pulido, Raúl Ferrer-Peña
The aim of this study was to determine the influence of expectations plus mobilization with movement (MWM) in kinesiophobia, perceived disability and sensorimotor variables in patients with lateral epicondylalgia. A pilot randomized controlled trial in 24 patients with lateral epicondylalgia was conducted. Perceived pain, pain-free grip strength, pressure pain detection threshold, kinesiophobia measured with the short version of Tampa Scale of Kinesiophobia, perceived disability of the upper limb measured with disability of the arm, hand and shoulder questionnaire, and perceived disability specifically for the elbow joint measured with patient-rating tennis elbow evaluation, and also satisfaction were assessed...
February 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28346629/the-marcus-welby-moment-mwm
#20
Susan Y Lee
No abstract text is available yet for this article.
March 2017: Family Medicine
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