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https://www.readbyqxmd.com/read/29777754/hmgb1-neutralization-attenuates-hippocampal-neuronal-death-and-cognitive-impairment-in-rats-with-chronic-cerebral-hypoperfusion-via-suppressing-inflammatory-responses-and-oxidative-stress
#1
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
High mobility group box-1 (HMGB1) acts as a proinflammatory molecule once released into the extracellular space and inhibition of HMGB1 signaling has been reported be neuroprotective in neurodegenerative diseases. Besides, chronic cerebral hypoperfusion (CCH) causes cognitive impairment in neurodegenerative diseases. Here we tested the protective role of HMGB1 inhibition using anti-HMGB1 neutralizing antibody (Ab) against CCH in rats after bilateral common carotid artery occlusion (2VO). 169 male Sprague-Dawley rats underwent 2VO or sham operation...
May 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29776417/sinomenine-exerts-anticonvulsant-profile-and-neuroprotective-activity-in-pentylenetetrazole-kindled-rats-involvement-of-inhibition-of-nlrp1-inflammasome
#2
Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang, Wen-Ning Wu
BACKGROUND: Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neuroprotective activity in many nervous system diseases. However, little is known about the effect of SN on epilepsy. METHODS: The chronic epilepsy model was established by pentylenetetrazole (PTZ) kindling...
May 18, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29772261/maternal-immune-activation-with-staphylococcal-enterotoxin-a-produces-unique-behavioral-changes-in-c57bl-6-mouse-offspring
#3
Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W Kusnecov
Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors. However, fewer studies have examined the role of direct activation of maternal T-cells during pregnancy using microbial agents...
May 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29761010/central-cholinergic-system-mediates-working-memory-deficit-induced-by-anesthesia-surgery-in-adult-mice
#4
Xiao Zhang, Xuliang Jiang, Lili Huang, Weitian Tian, Xuemei Chen, Xiyao Gu, Weifeng Yu, Jie Tian, Diansan Su
Background: Postoperative cognitive dysfunction (POCD) is consistently associated with increased morbidity and mortality, which has become a major concern of patients and caregivers. Although POCD occurs mainly in aged patients, it happens at any age. Previous studies demonstrated that anesthesia/surgery had no effects on reference memory of adult mice. However, whether it impairs working memory remains unclear. Working memory deficit would result in many deficits of executive function...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29754109/improving-effect-of-mild-foot-electrical-stimulation-on-pentylenetetrazole-induced-impairment-of-learning-and-memory
#5
Monir Abasi-Moghadam, Arefe Ghasemi-Dehno, Mehdi Sadegh, Mohammad Reza Palizvan
Epilepsy is a common neurological disorder that affects learning and memory. Recently it has been shown that mild foot electrical stimulation (MFES) can increase learning and memory in normal rats. Pentylenetetrazole (PTZ) kindling is a model of human epilepsy. As with human epilepsy, PTZ kindling impairs learning and memory in rats. The purpose of this study was to investigate the effect MFES on kindling-induced learning and memory deficits in rats. Forty-nine male Wistar rats weighting 200 to 250 g were divided into the following seven groups: PTZ only, phenytoin only, MFES only, PTZ plus phenytoin, PTZ plus MFES, phenytoin plus MFES, and saline (control), with the treatments administered for 26 days...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29751355/targeting-of-microrna-21-5p-protects-against-seizure-damage-in-a-kainic-acid-induced-status-epilepticus-model-via-pten-mtor
#6
Chongyang Tang, Yunhe Gu, Haiyang Wang, Hongmei Wu, Yu Wang, Yao Meng, Zhibin Han, Yifei Gu, Wei Ma, Zhenfeng Jiang, Yuanyuan Song, Meng Na, Dunyue Lu, Zhiguo Lin
OBJECTIVE: Studies have shown that microRNAs play a role in the development of epilepsy by regulating downstream target messenger (m)RNA. The present study aims to determine the changes associated with microRNA-21-5p (miR-21-5p) during epileptogenesis in a kainic acid rat model, and to assess whether the PTEN-mTOR pathway is a target of miR-21-5p. METHOD: Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the quantitative expressions of miR-21-5p and PTEN, and Western blotting was used to test the activity of mTOR in the acute, latent, and chronic stages of epileptogenesis...
May 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29750315/mobilization-with-movement-and-kinesio-taping-in-knee-arthritis-evaluation-and-outcomes
#7
Hülya Altmış, Deran Oskay, Bülent Elbasan, İrem Düzgün, Zeynep Tuna
INTRODUCTION: The aim of this study was to investigate the acute effects of Mulligan mobilization with movement (MwM) and taping on function and pain intensity in patients with osteoarthritis (OA). MATERIALS AND METHODS: Female patients aged between 40 and 70 years with knee OA participated in the study. The patients were divided into three groups and each group received different interventions. Group 1 received MwM and taping according to Mulligan's concept. Group 2 received MwM and placebo taping with no recovery effect and group 3 received placebo taping...
May 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29745257/beneficial-effects-of-urtica-dioica-on-scopolamine-induced-memory-impairment-in-rats-protection-against-acetylcholinesterase-activity-and-neuronal-oxidative-damage
#8
Simagol Ghasemi, Malihe Moradzadeh, Mahmoud Hosseini, Farimah Beheshti, Hamid Reza Sadeghnia
This study was conducted to investigate protective effects of Urtica dioica extract on acetylcholinesterase (AChE) activity and the oxidative damage of brain tissues in scopolamine-induced memory impairment model. The rats were treated with (1) saline (control), (2) scopolamine, and (3-5) the plant extract (20, 50, or 100 mg/kg) before scopolamine. The traveled distance and the latency to find the platform in Morris water maze (MWM) by scopolamine-treated group were longer while the time spent in target quadrant was shorter than those of the control...
May 10, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29740317/-moringa-oleifera-seed-extract-alleviates-scopolamine-induced-learning-and-memory-impairment-in-mice
#9
Juan Zhou, Wu-Shuang Yang, Da-Qin Suo, Ying Li, Lu Peng, Lan-Xi Xu, Kai-Yue Zeng, Tong Ren, Ying Wang, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Jin
The extract of Moringa oleifera seeds has been shown to possess various pharmacological properties. In the present study, we assessed the neuropharmacological effects of 70% ethanolic M. oleifera seed extract (MSE) on cognitive impairment caused by scopolamine injection in mice using the passive avoidance and Morris water maze (MWM) tests. MSE (250 or 500 mg/kg) was administered to mice by oral gavage for 7 or 14 days, and cognitive impairment was induced by intraperitoneal injection of scopolamine (4 mg/kg) for 1 or 6 days...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29736859/pigment-epithelium-derived-factor-plays-a-role-in-alzheimer-s-disease-by-negatively-regulating-a%C3%AE-42
#10
Mao Huang, Weiwei Qi, Shuhuan Fang, Ping Jiang, Cong Yang, Yousheng Mo, Chang Dong, Yan Li, Jun Zhong, Weibin Cai, Zhonghan Yang, Ti Zhou, Qi Wang, Xia Yang, Guoquan Gao
Alzheimer's disease (AD) is the most common cause of dementia. Pigment epithelium-derived factor (PEDF), a unique neurotrophic protein, decreases with aging. Previous reports have conflicted regarding whether the PEDF concentration is altered in AD patients. In addition, the effect of PEDF on AD has not been documented. Here, we tested serum samples of 31 AD patients and 271 normal controls. We found that compared to PEDF levels in young and middle-aged control subjects, PEDF levels were reduced in old-aged controls and even more so in AD patients...
May 7, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29735445/-effect-of-intrahippocampal-injection-of-anti-cellular-prion-protein-monoclonal-antibody-on-cognitive-deficits-in-appswe-psen1-de9-transgenic-mice
#11
Hai-Ying Zhang, Yi-Heng Liu, Yuan Fu, Peng-Cheng Chen, Rui Lu, Jian-Xing Li, Ming-Hui Chen, Hao-Chi Yang, Yu-Sheng Zhang
OBJECTIVE: To study the effects of intrahippocampal injection of cellular prion protein (PrPC ) antibody on cognitive deficits of APPswe/PSEN1dE9 transgenic mice. METHODS: Eight-month-old male APPswe/PSEN1dE9 transgenic mice were subjected to bilateral intrahippocampal injection of a single dose (2 µL) of anti-PrPC monoclonal antibody (EP1802Y) or PBS, with wild-type C57Bl/6J mice serving as the control group. After two months, the mice were tested for cognitive behaviors using open filed (OF) test, Morris water maze (MWM) test, fear conditioning (FC) test, and novel object recognition (NOR) test, and immunohistochemistry was used to examine the changes in hippocampal expression of Aβ1-42 ...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29731813/sevoflurane-induced-memory-impairment-in-the-postnatal-developing-mouse-brain
#12
Zhijun Lu, Jihui Sun, Yichun Xin, Ken Chen, Wen Ding, Yujia Wang
The aim of the present study was to confirm that sevoflurane induces memory impairment in the postnatal developing mouse brain and determine its mechanism of action. C57BL/6 mice 7 days old were randomly assigned into a 2.6% sevoflurane (n=68), a 1.3% sevoflurane (n=68) and a control (n=38) group. Blood gas analysis was performed to evaluate hypoxia and respiratory depression during anesthesia in 78 mice. Measurements for expression of caspase-3 by immunohistochemistry, cleavage of poly adenosine diphosphate-ribose polymerase (PARP) by western blotting, as well as levels of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor type 2 (Ntrk2), pro-BDNF, p75 neurotrophin receptor (p75NTR) and protein kinase B (PKB/Akt) by enzyme-linked immunosorbent assay were performed in the hippocampus of 12 mice from each group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29730669/corilagin-reduces-the-frequency-of-seizures-and-improves-cognitive-function-in-a-rat-model-of-chronic-epilepsy
#13
Xue Yu, Tao Zhou, Heng Yu, Li-Ying Chang, Ling-Li Wei
BACKGROUND Worldwide, epilepsy is an important chronic neurological condition. The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy. MATERIAL AND METHODS Chronic epilepsy was induced in male Wistar rats by intraperitoneal (IP) injection of pentylenetetrazol (PTZ) for 36 days. Corilagin, 10 mg/kg and 20 mg/kg, was injected IP into treated rats, 24 days before the start of PTZ treatment, until the end of the protocol...
May 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29726088/a-novel-2-phenylamino-quinazoline-based-compound-expands-the-neural-stem-cell-pool-and-promotes-the-hippocampal-neurogenesis-and-the-cognitive-ability-of-adult-mice
#14
Lu Hui, Cheng Gang, Hong Feng, Zhang Lei, Hu Youhong, Feng Linyin
The adult neurogenesis occurs throughout the life of the mammalian hippocampus and is found to be essential for learning and memory. Identifying new ways to manipulate the number of neural stem cells (NSCs) and enhance endogenous neurogenesis in adult is very important. Here we found that a novel compound, N2-(4-isopropylphenyl)-5-(3-methoxyphenoxy)quinazoline-2,4-diamine (code-named Yhhu-3792), enhanced the self-renewal capability of NSCs in vitro and in vivo. In vitro, Yhhu-3792 increased the ratio of BrdU + /DAPI+ embryonic NSCs and accelerated the growth of neurospheres significantly...
May 3, 2018: Stem Cells
https://www.readbyqxmd.com/read/29723266/recognition-of-early-stage-thigmotaxis-in-morris-water-maze-test-with-convolutional-neural-network
#15
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
The Morris water maze test (MWM) is a useful tool to evaluate rodents' spatial learning and memory, but the outcome is susceptible to various experimental conditions. Thigmotaxis is a commonly observed behavioral pattern which is thought to be related to anxiety or fear. This behavior is associated with prolonged escape latency, but the impact of its frequency in the early stage on the final outcome is not clearly understood. We analyzed swim path trajectories in male C57BL/6 mice with or without bilateral common carotid artery stenosis (BCAS) treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29715445/effect-of-running-exercise-on-the-number-of-the-neurons-in-the-hippocampus-of-young-transgenic-app-ps1-mice
#16
Lin Jiang, Jing Ma, Yi Zhang, Chun-Ni Zhou, Lei Zhang, Feng-Lei Chao, Lin-Mu Chen, Rong Jiang, Hong Wu, Yong Tang
To investigate the effect of running exercise on the number of the neurons in the hippocampus of young APP/PS1mice, twenty 6-month-old male APP/ PS1 transgenic mice were randomly divided into the APP/PS1 control (AD control) group and the APP/PS1 running (AD running) group (10 mice per group), and ten wild-type mice of the littermate were regarded as the wild-type (WT) group. The AD running mice ran on motorized treadmill machiene for 4 months, while the WT mice and AD control mice were housed in standard condition without running...
April 28, 2018: Brain Research
https://www.readbyqxmd.com/read/29715265/mice-lacking-the-transcriptional-regulator-bhlhe40-have-enhanced-neuronal-excitability-and-impaired-synaptic-plasticity-in-the-hippocampus
#17
Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattson
Bhlhe40 is a transcription factor that is highly expressed in the hippocampus; however, its role in neuronal function is not well understood. Here, we used Bhlhe40 null mice on a congenic C57Bl6/J background (Bhlhe40 KO) to investigate the impact of Bhlhe40 on neuronal excitability and synaptic plasticity in the hippocampus. Bhlhe40 KO CA1 neurons had increased miniature excitatory post-synaptic current amplitude and decreased inhibitory post-synaptic current amplitude, indicating CA1 neuronal hyperexcitability...
2018: PloS One
https://www.readbyqxmd.com/read/29705395/imperatorin-ameliorates-lipopolysaccharide-induced-memory-deficit-by-mitigating-proinflammatory-cytokines-oxidative-stress-and-modulating-brain-derived-neurotropic-factor
#18
Amrita A Chowdhury, Nitin B Gawali, Prashant Shinde, Renuka Munshi, Archana R Juvekar
BACKGROUND: Lipopolysaccharide (LPS), an endotoxin from the outer membrane of Gram negative bacteria has been reported to cause neuroinflammation and learning and memory deficits. There are reports describing the beneficial effects of Imperatorin (IMP), a naturally occurring furanocoumarin in central nervous system (CNS) disorders such as anxiety and epilepsy. OBJECTIVE: In the current study, we investigated whether IMP protects against LPS mediated memory deficits and neuroinflammation...
April 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29705077/do-joint-mobilizations-assist-in-the-recovery-of-lateral-elbow-tendinopathy-a-systematic-review-and-meta-analysis
#19
Ann M Lucado, R Barry Dale, Joshua Vincent, Joseph M Day
STUDY DESIGN: Systematic review. INTRODUCTION: No consensus exists as to which are the most effective methods to treat the symptoms associated with lateral elbow tendinopathy (LET). Research has suggested that joint mobilizations may assist in the recovery of patients with LET. PURPOSE OF THE STUDY: To determine if joint mobilizations are effective in improving pain, grip strength, and disability in adults with LET. METHODS: Searches in 3 databases were performed to identify relevant clinical trials...
April 25, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29702177/whole-body-pulsed-emf-stimulation-improves-cognitive-and-psychomotor-activity-in-senescent-rats
#20
Tímea Téglás, Gabriella Dörnyei, Károly Bretz, Csaba Nyakas
During advanced aging passive exercise (PE) is becoming a valuable therapeutic intervention to improve physical and mental performances. In the present study chronic low frequency pulsed electromagnetic field (EMF) exposure was presented to senescent rats in order to clarify the behavioural effects related to cognitive and motility functions. Male Wistar rats of 30-32 months old were treated with EMF for six weeks, 3 times per week, 24 min per sessions prior to the age of 32 months. Stimulation intensities varied from 45 to 1250 µT...
April 24, 2018: Behavioural Brain Research
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