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https://www.readbyqxmd.com/read/28804233/effects-of-physical-activity-and-ginkgo-biloba-on-cognitive-function-and-oxidative-stress-modulation-in-ischemic-rats
#1
Ladan Vaghef, Hassan Bafandeh Gharamaleki
Either exercise or Ginkgo biloba is reported to improve cognitive functioning. The aim of this study is to compare the protective effects of forced exercise and Ginkgo biloba on oxidative stress as well as memory impairments induced by transient cerebral ischemia. Adult male Wistar rats were treated with treadmill running or Ginkgo biloba extract for 2 weeks before cerebral ischemia. Memory was assessed using a Morris water maze (MWM) task. At the end of the behavioral testing, oxidative stress biomarkers were evaluated in the hippocampus tissue...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28800326/intracerebroventricular-streptozotocin-induces-obesity-and-dementia-in-lewis-rats-rat-model-of-dementia-associated-with-obesity
#2
Konstantin Bloch, Irit Gil-Ad, Alexey Vanichkin, Shay Henry Hornfeld, Nickolay Koroukhov, Michal Taler, Pnina Vardi, Abraham Weizman
BACKGROUND: Animal models of dementia associated with metabolic abnormalities play an important role in understanding the bidirectional relationships between these pathologies. Rodent strains develop cognitive dysfunctions without alteration of peripheral metabolism following intracerebroventricular administration of streptozotocin (icv-STZ). OBJECTIVE: We aimed to estimate the effect of icv-STZ on cognitive functions and peripheral metabolism in Lewis rats, which are rarely used for the induction of cognitive abnormalities...
August 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28798681/dl-3-n-butylphthalide-treatment-enhances-hemodynamics-and-ameliorates-memory-deficits-in-rats-with-chronic-cerebral-hypoperfusion
#3
Zhilin Xiong, Weibiao Lu, Lihui Zhu, Ling Zeng, Changzheng Shi, Zhen Jing, Yonghui Xiang, Wenxian Li, Chi Kwan Tsang, Yiwen Ruan, Li'an Huang
Our previous study has revealed that chronic cerebral hypoperfusion (CCH) activates a compensatory vascular mechanism attempting to maintain an optimal cerebral blood flow (CBF). However, this compensation fails to prevent neuronal death and cognitive impairment because neurons die prior to the restoration of normal CBF. Therefore, pharmacological invention may be critical to enhance the CBF for reducing neurodegeneration and memory deficit. Dl-3-n-butylphthalide (NBP) is a compound isolated from the seeds of Chinese celery and has been proven to be able to prevent neuronal loss, reduce inflammation and ameliorate memory deficits in acute ischemic animal models and stroke patients...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28781732/protective-effects-of-cyperus-rotundus-extract-on-amyloid-%C3%AE-peptide-1-40-induced-memory-impairment-in-male-rats-a-behavioral-study
#4
Mehdi Mehdizadeh, Fataneh Hashem Dabaghian, Asie Shojaee, Nima Molavi, Zahra Taslimi, Ronak Shabani, Sara Soleimani Asl
INTRODUCTION: The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment. METHODS: Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally)...
May 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28781729/the-modulatory-role-of-orexin-1-receptor-in-ca1-on-orofacial-pain-induced-learning-and-memory-deficits-in-rats
#5
Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoof
INTRODUCTION: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain. METHODS: Orofacial pain was induced by subcutaneous intra lip injection of capsaicin (100 μg)...
May 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28771808/camp-pka-signaling-pathway-contributes-to-neuronal-apoptosis-via-regulating-ide-expression-in-a-mixed-model-of-type-2-diabetes-and-alzheimer-s-disease
#6
Huajie Li, Song Yang, Jian Wu, Lei Ji, Linfeng Zhu, Liping Cao, Jinzhong Huang, Qingqing Jiang, Jiang Wei, Meng Liu, Keshi Mao, Ning Wei, Wei Xie, Zhilong Yang
Type 2 diabetes (T2D) may play a relevant role in the development of Alzheimer's disease (AD), however, the underlying mechanism was not clear yet. We developed an animal model presenting both AD and T2D, morris water maze (MWM) test and recognition task were performed to trace the cognitive function. Fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) were determined to trace the metabolism evolution. TUNEL assay and apoptosis-related protein levels were analyzed for the detection of neuronal apoptosis...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28769765/mesenchymal-stem-cell-derived-extracellular-vesicles-ameliorates-hippocampal-synaptic-impairment-after-transient-global-ischemia
#7
Mingyang Deng, Han Xiao, Hainan Zhang, Hongling Peng, Huan Yuan, Yunxiao Xu, Guangsen Zhang, Zhiping Hu
Recent studies have found that administration of stem cells or extracellular vehicles (EVs) derived from stem cells exert neuroprotective effects after transient global ischemia. However, the underlying mechanisms of this effect remain unclear, especially at the level of synaptic functions. In this study, we compared the suppressive effects on cyclooxygenase-2 (COX-2) upregulation by EVs derived from bone marrow mesenchymal stem cells (BMSC-EV), adipose tissue MSC (AdMSC-EV) and serum (serum-EV). Then we examined whether BMSC-EVs could restore functional integrity of synaptic transmission and plasticity...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28767442/hydrogen-sulfide-ameliorates-cognitive-dysfunction-in-streptozotocin-induced-diabetic-rats-involving-suppression-in-hippocampal-endoplasmic-reticulum-stress
#8
Wei Zou, Juan Yuan, Zhuo-Jun Tang, Hai-Jun Wei, Wei-Wen Zhu, Ping Zhang, Hong-Feng Gu, Chun-Yan Wang, Xiao-Qing Tang
Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H2S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits the hippocampal ER stress in homocysteine-exposed rats. Therefore, this aim of the present work was to investigate whether H2S ameliorates the diabetic cognitive dysfunction involving inhibition of hippocampal ER stress...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766351/the-impact-of-sleep-deprivation-on-hippocampal-mediated-learning-and-memory-in-rats
#9
M Saygin, M F Ozguner, O Onder, D K Doguc, I Ilhan, Y Peker
BACKGROUND: To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats. METHODS: Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total sleep deprivation (TSD), (3) rapid eye movement (REM) deprivation (RD), and (4) sleep restricted to 4 hours per day (SR). All rats were subjected to swimming training in the Morris water maze (MWM)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28757160/mitochondrial-impairments-contribute-to-spatial-learning-and-memory-dysfunction-induced-by-chronic-tramadol-administration-in-rat-protective-effect-of-physical-exercise
#10
Hajar Mehdizadeh, Jalal Pourahmad, Ghorban Taghizadeh, Nasim Vousooghi, Ali Yoonessi, Parvaneh Naserzadeh, Ladan Behzadfar, Mohammad Reza Rouini, Mohammad Sharifzadeh
Despite the worldwide use of tramadol, few studies have been conducted about its effects on memory and mitochondrial function, and controversial results have been reported. Recently, there has been an increasing interest in physical exercise as a protective approach to neuronal and cognitive impairments. Therefore, the aim of this study was to investigate the effects of physical exercise on spatial learning and memory and brain mitochondrial function in tramadol-treated rats. After completion of 2-week (short-term) and 4-week (long-term) treadmill exercise regimens, male Wistar rats received tramadol (20, 40, 80mg/kg/day) intraperitoneally for 30days...
July 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28756201/multiple-mild-traumatic-brain-injury-in-the-rat-produces-persistent-pathological-alterations-in-the-brain
#11
Diane M Brooks, Sarjubhai A Patel, Eric D Wohlgehagen, Erin O Semmens, Alan Pearce, Edmond A Sorich, Thomas F Rau
Multiple mild traumatic brain injury (mmTBI), in certain cases, produces persistent symptoms. However, the molecular mechanisms underlying these symptoms remain unclear. Here, we demonstrate extended pathological changes in the rat brain following mmTBI. Using the lateral fluid percussion (LFP) technique we exposed adult male Wistar rats to a mild TBI (mTBI) once a week for four weeks and compared them to surgical shams. At 90days following the last TBI or sham procedure the animals were cognitively tested in the Morris Water Maze (MWM), euthanized, and the brains removed for immunohistochemistry...
July 27, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28751078/the-quality-improvement-environment-results-of-the-2016-aahpm-hpna-membership-needs-assessment-survey
#12
Lisa C Lindley, Joseph D Rotella, Katherine Ast, Marianne Matzo, Arif H Kamal
CONTEXT: The American Academy of Hospice and Palliative Medicine (AAHPM) and Hospice and Palliative Nurses Association (HPNA) convened the Measuring What Matters (MWM) initiative in 2013, which recommended ten quality performance measures; yet, little is known about the quality improvement (QI) environment and implementation of the MWM among hospices and palliative care services. OBJECTIVES: To describe the findings of the 2016 AAHPM/HPNA Needs Assessment survey exploring the QI environment among hospice and palliative care services...
July 24, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28740463/terminal-differentiation-of-adult-hippocampal-progenitor-cells-is-a-step-functionally-dissociable-from-proliferation-and-is-controlled-by-tis21-id3-and-neurod2
#13
Laura Micheli, Manuela Ceccarelli, Roberta Gioia, Giorgio D'Andrea, Stefano Farioli-Vecchioli, Marco Costanzi, Daniele Saraulli, Vincenzo Cestari, Felice Tirone
Cell proliferation and differentiation are interdependent processes. Here, we have asked to what extent the two processes of neural progenitor cell amplification and differentiation are functionally separated. Thus, we analyzed whether it is possible to rescue a defect of terminal differentiation in progenitor cells of the dentate gyrus, where new neurons are generated throughout life, by inducing their proliferation and/or their differentiation with different stimuli appropriately timed. As a model we used the Tis21 knockout mouse, whose dentate gyrus neurons, as demonstrated by us and others, have an intrinsic defect of terminal differentiation...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28739248/the-protective-effect-of-hydrogen-sulfide-h2s-on-traumatic-brain-injury-tbi-induced-memory-deficits-in-rats
#14
Seyed Asaad Karimi, Narges Hosseinmardi, Mahyar Janahmadi, Mohammad Sayyah, Razieh Hajisoltani
Traumatic brain injury (TBI), as an expanding public health epidemic, is a common cause of death among youth. TBI is associated with cognitive deficits and memory impairment. Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the central nervous system. In the present study the potential neuroprotective role of sodium hydrosulfide (NaHS), an H2S donor on TBI induced memory deficit in a rat model of controlled cortical impact (CCI) injury was investigated...
July 22, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28706608/the-effects-of-melilotus-officinalis-extract-on-expression-of-daxx-nfkb-and-vegf-genes-in-the-streptozotocin-induced-rat-model-of-sporadic-alzheimer-s-disease
#15
Niloofar Bazazzadegan, Marzieh Dehghan Shasaltaneh, Kioomars Saliminejad, Koorosh Kamali, Mehdi Banan, Hamid Reza Khorram Khorshid
BACKGROUND: Possible mechanisms of Alzheimer Disease (AD) such as inflammation and oxidative stresses in the brain led us to investigate potential AD therapeutics of Melilotus officinalis, an herbal extract, with possible role as an anti-inflammatory and anti-oxidant agent. Among different genes which had important role in Sporadic AD (SAD), three genes including DAXX, NFkB and VEGF have shown significant statistical diversity in the brains of Alzheimer patients. METHODS: These genes were chosen to be investigated for neuroprotective effects of the extract by comparing the expression level in the hippocampus of Sporadic AD (SAD) rat model using quantitative polymerase chain reaction (qPCR) in the treated and untreated groups...
July 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28705715/acute-treatment-with-doxorubicin-affects-glutamate-neurotransmission-in-the-mouse-frontal-cortex-and-hippocampus
#16
Theresa Currier Thomas, Joshua A Beitchman, Francois Pomerleau, Teresa Noel, Paiboon Jungsuwadee, D Allan Butterfield, Daret K St Clair, Mary Vore, Greg A Gerhardt
Doxorubicin (DOX) is a potent chemotherapeutic agent known to cause acute and long-term cognitive impairments in cancer patients. Cognitive function is presumed to be primarily mediated by neuronal circuitry in the frontal cortex (FC) and hippocampus, where glutamate is the primary excitatory neurotransmitter. Mice treated with DOX (25 mg/kg i.p.) were subjected to in vivo recordings under urethane anesthesia at 24h post-DOX injection or 5 consecutive days of cognitive testing (Morris Water Maze; MWM). Using novel glutamate-selective microelectrode arrays, amperometric recordings measured parameters of extracellular glutamate clearance and potassium-evoked release of glutamate within the medial FC and dentate gyrus (DG) of the hippocampus...
July 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28691424/an-animal-model-of-the-procognitive-properties-of-cysteine-protease-inhibitor-and-immunomodulatory-peptides-based-on-colostrum
#17
Bartłomiej Stańczykiewicz, Marta Jakubik-Witkowska, Antoni Polanowski, Tadeusz Trziszka, Joanna Rymaszewska
BACKGROUND: The positive effect of human cystatin C on the development of Alzheimer's disease has been reported, as it inhibits the formation of β-amyloid oligomers and amyloidogenesis. Cystatin C has been found to have a neuroprotective effect through inhibiting cysteine proteases, inducing autophagy and neurogenesis. There is a growing interest in the procognitive properties of colostrum-based specimens, which could delay dementia and ameliorate memory deterioration. OBJECTIVES: The aim of the study was to evaluate the influence of Ovocystatin and a Coloco peptide complex on the cognitive functions in reference to Colostrinin, using a model of young and old rats...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28684969/electroacupuncture-alleviates-postoperative-cognitive-dysfunction-in-aged-rats-by-inhibiting-hippocampal-neuroinflammation-activated-via-microglia-tlrs-pathway
#18
Pei-Pei Feng, Pu Deng, Li-Hua Liu, Qi Ai, Jie Yin, Zhe Liu, Gai-Mei Wang
Neuroinflammation has been suggested to be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). Electroacupuncture (EA) is an irreplaceable method in traditional Chinese medicine that is used for treating neurodegenerative diseases in clinical and experimental studies. The aim of this study was to examine whether EA improves cognitive dysfunction caused by surgery and to investigate the pathological mechanism of TLR2 and TLR4 in the hippocampus of aged rats. A rat model of POCD was established and treated with EA or minocycline...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28683457/mir-9-regulates-the-expression-of-bace1-in-dementia-induced-by-chronic-brain-hypoperfusion-in-rats
#19
Hailong Xie, Ying Zhao, You Zhou, Lin Liu, Yueting Liu, Dongxue Wang, Shuang Zhang, Mingyan Yang
BACKGROUND/AIMS: MicroRNA-9 (miR-9) plays important roles in nervous system diseases such as glioblastoma and neurodegenerative disorders. However, how miR-9 contributes to dementia requires further study. In this study, we evaluated the role of miR-9 in dementia and the molecular mechanisms underlying its effects. METHODS: A rat model of dementia was created by occlusion of the bilateral common carotid artery (2VO) for 8 weeks. Learning and memory were assessed using the Morris Water Maze (MWM)...
July 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28662189/affective-and-cognitive-behavior-in-the-alpha-galactosidase-a-deficient-mouse-model-of-fabry-disease
#20
Lukas Hofmann, Franziska Karl, Claudia Sommer, Nurcan Üçeyler
Fabry disease is an X-linked inherited lysosomal storage disorder with intracellular accumulation of globotriaosylceramide (Gb3) due to α-galactosidase A (α-Gal A) deficiency. Fabry patients frequently report of anxiety, depression, and impaired cognitive function. We characterized affective and cognitive phenotype of male mice with α-Gal A deficiency (Fabry KO) and compared results with those of age-matched male wildtype (WT) littermates. Young (3 months) and old (≥ 18 months) mice were tested in the naïve state and after i...
2017: PloS One
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