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Chirag parikh

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https://www.readbyqxmd.com/read/29130810/outcomes-after-angiography-with-sodium-bicarbonate-and-acetylcysteine
#1
Steven D Weisbord, Martin Gallagher, Hani Jneid, Santiago Garcia, Alan Cass, Soe-Soe Thwin, Todd A Conner, Glenn M Chertow, Deepak L Bhatt, Kendrick Shunk, Chirag R Parikh, Edward O McFalls, Mary Brophy, Ryan Ferguson, Hongsheng Wu, Maria Androsenko, John Myles, James Kaufman, Paul M Palevsky
Background Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. Methods Using a 2-by-2 factorial design, we randomly assigned 5177 patients at high risk for renal complications who were scheduled for angiography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride and 5 days of oral acetylcysteine or oral placebo; of these patients, 4993 were included in the modified intention-to-treat analysis...
November 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29074166/association-between-high-environmental-heat-and-risk-of-acute-kidney-injury-among-older-adults-in-a-northern-climate-a-matched-case-control-study
#2
Rebecca K McTavish, Lucie Richard, Eric McArthur, Salimah Z Shariff, Rey Acedillo, Chirag R Parikh, Ron Wald, Piotr Wilk, Amit X Garg
BACKGROUND: An association between high heat and acute kidney injury (AKI) has been reported in warm climates. However, whether this association generalizes to a northern climate, with more variable temperatures, is unknown. STUDY DESIGN: Matched case-control study. SETTING & PARTICIPANTS: Our study focused on older adults (mean age, 80 years) in the northern climate of Ontario, Canada. 52,913 case patients who had a hospital encounter with AKI in April through September 2005 to 2012 were matched with 174,222 controls for exact date, age, sex, rural residence, income, and history of chronic kidney disease...
October 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29070568/il-33-deficiency-slows-cancer-growth-but-does-not-protect-against-cisplatin-induced-aki-in-mice-with-cancer
#3
Kameswaran Ravichandran, Sara Holditch, Carolyn N Brown, Qian Wang, Abdullah Ozkok, Mary Cm Weiser-Evans, Raphael A Nemenoff, Makoto Miyazaki, Heather Thiessen-Philbrook, Chirag R Parikh, Danica Ljubanovic, Charles Louis Edelstein
The effect of IL-33 deficiency on AKI and cancer growth in a 4 week model of cisplatin-induced AKI in mice with cancer was determined. Mice were injected subcutaneously with murine lung cancer cells. Ten days later, cisplatin (10 mg/kg/week) was administered weekly for 4 weeks. The increase in kidney IL-33 preceded the AKI and tubular injury suggesting that IL-33 may play a causative role. However, the increase in serum creatinine, BUN, serum NGAL, ATN and apoptosis scores in the kidney in cisplatin-induced AKI was the same in wild type and IL-33 deficient mice...
October 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28992097/association-of-serum-albumin-levels-with-kidney-function-decline-and-incident-chronic-kidney-disease-in-elders
#4
Joshua Lang, Ronit Katz, Joachim H Ix, Orlando M Gutierrez, Carmen A Peralta, Chirag R Parikh, Suzanne Satterfield, Snezana Petrovic, Prasad Devarajan, Michael Bennett, Linda F Fried, Steven R Cummings, Mark J Sarnak, Michael G Shlipak
Background: Previous studies in HIV-infected individuals have demonstrated serum albumin to be strongly associated with kidney function decline, independent of urine albumin and inflammatory markers. Lower serum albumin concentrations may be an under-appreciated risk factor for kidney function decline in elders. Methods: We performed a cohort analysis in the Health Aging and Body Composition Study, a cohort of well-functioning, bi-racial, community-dwelling elders between the age of 70 and 79 years...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28882126/predictors-of-acute-renal-injury-study-paris-among-hiv-positive-individuals-design-and-methods
#5
Celia P Corona-Villalobos, Michael G Shlipak, Adrienne Tin, Chirag Parikh, Richard D Moore, Eric Vittinghoff, Jose Manuel Monroy-Trujillo, Mohamed G Atta, Michelle M Estrella
BACKGROUND: Acute kidney injury (AKI), which is common among HIV-positive individuals, may contribute to the excess burden of chronic kidney disease (CKD) in this patient population; however, conventional clinical methods to detect AKI do not capture kidney injury sufficiently early to prevent irreversible damage. Further, large observational and interventional studies of AKI generally exclude HIV-positive persons in spite of their disproportionate risk. METHODS: The Predictors of Acute Renal Injury Study (PARIS) is a prospective observational cohort study among HIV-positive individuals established to determine the ability of candidate kidney injury biomarkers to predict future hospitalized clinical AKI, to characterize hospitalized subclinical AKI, and to discern the risk of progressive kidney disease following subclinical and clinical AKI...
September 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28844586/performance-of-serum-creatinine-and-kidney-injury-biomarkers-for-diagnosing-histologic-acute-tubular-injury
#6
Dennis G Moledina, Isaac E Hall, Heather Thiessen-Philbrook, Peter P Reese, Francis L Weng, Bernd Schröppel, Mona D Doshi, F Perry Wilson, Steven G Coca, Chirag R Parikh
BACKGROUND: The diagnosis of acute kidney injury (AKI), which is currently defined as an increase in serum creatinine (Scr) concentration, provides little information on the condition's actual cause. To improve phenotyping of AKI, many urinary biomarkers of tubular injury are being investigated. Because AKI cases are not frequently biopsied, the diagnostic accuracy of concentrations of Scr and urinary biomarkers for histologic acute tubular injury is unknown. STUDY DESIGN: Cross-sectional analysis from multicenter prospective cohort...
August 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28821332/interleukin-8-and-tumor-necrosis-factor-predict-acute-kidney-injury-after-pediatric-cardiac-surgery
#7
Christina A de Fontnouvelle, Jason H Greenberg, Heather R Thiessen-Philbrook, Michael Zappitelli, Jeremy Roth, Kathleen F Kerr, Prasad Devarajan, Michael Shlipak, Steven Coca, Chirag R Parikh
BACKGROUND: Inflammation is a key component of both acute kidney injury (AKI) and response to cardiopulmonary bypass. Because AKI poses risks to children after cardiac surgery, we investigated the value of inflammatory biomarkers interleukin-8 (IL-8) and tumor necrosis factor alpha (TNFα) for predicting AKI and other complications. METHODS: We enrolled 412 children between the ages of 1 month and 18 years undergoing cardiopulmonary bypass for cardiac surgery. We collected blood both preoperatively and postoperatively (within 6 hours post-surgery) and measured plasma IL-8 and TNFα...
August 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28808078/relationship-of-kidney-injury-biomarkers-with-long-term-cardiovascular-outcomes-after-cardiac-surgery
#8
Chirag R Parikh, Jeremy Puthumana, Michael G Shlipak, Jay L Koyner, Heather Thiessen-Philbrook, Eric McArthur, Kathleen Kerr, Peter Kavsak, Richard P Whitlock, Amit X Garg, Steven G Coca
Clinical AKI, measured by serum creatinine elevation, is associated with long-term risks of adverse cardiovascular (CV) events and mortality in patients after cardiac surgery. To evaluate the relative contributions of urine kidney injury biomarkers and plasma cardiac injury biomarkers in adverse events, we conducted a multicenter prospective cohort study of 968 adults undergoing cardiac surgery. On postoperative days 1-3, we measured five urine biomarkers of kidney injury (IL-18, NGAL, KIM-1, L-FABP, and albumin) and five plasma biomarkers of cardiac injury (NT-proBNP, H-FABP, hs-cTnT, cTnI, and CK-MB)...
August 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28795578/evaluating-biomarkers-for-prognostic-enrichment-of-clinical-trials
#9
Kathleen F Kerr, Jeremy Roth, Kehao Zhu, Heather Thiessen-Philbrook, Allison Meisner, Francis Perry Wilson, Steven Coca, Chirag R Parikh
BACKGROUND/AIMS: A potential use of biomarkers is to assist in prognostic enrichment of clinical trials, where only patients at relatively higher risk for an outcome of interest are eligible for the trial. We investigated methods for evaluating biomarkers for prognostic enrichment. METHODS: We identified five key considerations when considering a biomarker and a screening threshold for prognostic enrichment: (1) clinical trial sample size, (2) calendar time to enroll the trial, (3) total patient screening costs and the total per-patient trial costs, (4) generalizability of trial results, and (5) ethical evaluation of trial eligibility criteria...
August 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28683730/urinalysis-findings-and-urinary-kidney-injury-biomarker-concentrations
#10
Girish N Nadkarni, Steven G Coca, Allison Meisner, Shanti Patel, Kathleen F Kerr, Uptal D Patel, Jay L Koyner, Amit X Garg, Heather Thiessen Philbrook, Charles L Edelstein, Michael Shlipak, Joe El-Khoury, Chirag R Parikh
INTRODUCTION: Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors are associated with urinary biomarker levels. METHODS: We examined 714 adults who underwent cardiac surgery in the TRIBE-AKI cohort that did not experience post-operative clinical AKI (patients with serum creatinine change of ≥ 20% were excluded)...
July 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28667085/biomarkers-for-diagnosis-and-prognosis-of-aki-in-children-one-size-does-not-fit-all
#11
REVIEW
Jason H Greenberg, Chirag R Parikh
Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI...
September 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28624980/emerging-biomarkers-of-chronic-kidney-disease-in-children
#12
REVIEW
Jason H Greenberg, Aadil Kakajiwala, Chirag R Parikh, Susan Furth
Chronic kidney disease (CKD) has become a significant public health concern, as it is associated with substantial morbidity. Prior research has evaluated multiple novel CKD biomarkers to supplement serum creatinine and proteinuria. The ultimate goal of this research is to find biomarkers that can be used to accurately predict CKD progression and to better time outpatient follow-up, and referral for transplant. Also, an optimal panel of biomarkers can augment the predictive value of proteinuria and serum creatinine by enriching patient enrollment in clinical trials...
June 17, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28485029/surface-enhanced-raman-scattering-analysis-of-urine-from-deceased-donors-as-a-prognostic-tool-for-kidney-transplant-outcome
#13
Jingmao Chi, Yiwei Ma, Francis L Weng, Heather Thiessen-Philbrook, Chirag R Parikh, Henry Du
We report the utility of surface-enhanced Raman scattering (SERS) analysis of urine from deceased donors for prognosis of kidney transplant outcomes. Iodide-modified silver nanoparticles were used as the enabler for sensitive measurements of urine proteins. Principal component analysis (PCA) and linear discriminant analysis (LDA) were employed for the statistical analysis of the SERS data. Thirty urine samples in three classes were analysed. The ATN class consists of donors whose kidneys had acute tubular necrosis (ATN), the most common type of acute kidney injury (AKI) with high risk of poor graft performance in recipients, yet yielded acceptable transplant outcome...
May 9, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28476763/plasma-biomarkers-and-kidney-function-decline-in-early-and-established-diabetic-kidney-disease
#14
Steven G Coca, Girish N Nadkarni, Yuan Huang, Dennis G Moledina, Veena Rao, Jane Zhang, Bart Ferket, Susan T Crowley, Linda F Fried, Chirag R Parikh
Biomarkers of diverse pathophysiologic mechanisms may improve risk stratification for incident or progressive diabetic kidney disease (DKD) in persons with type 2 diabetes. To evaluate such biomarkers, we performed a nested case-control study (n=190 cases of incident DKD and 190 matched controls) and a prospective cohort study (n=1156) using banked baseline plasma samples from participants of randomized, controlled trials of early (ACCORD) and advanced (VA NEPHRON-D) DKD. We assessed the association and discrimination obtained with baseline levels of plasma TNF receptor-1 (TNFR-1), TNFR-2, and kidney injury molecule-1 (KIM-1) for the outcomes of incident DKD (ACCORD) and progressive DKD (VA-NEPHRON-D)...
September 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28434650/global-kidney-health-2017-and-beyond-a-roadmap-for-closing-gaps-in-care-research-and-policy
#15
REVIEW
Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, Kai-Uwe Eckardt
The global nephrology community recognises the need for a cohesive plan to address the problem of chronic kidney disease (CKD). In July, 2016, the International Society of Nephrology hosted a CKD summit of more than 85 people with diverse expertise and professional backgrounds from around the globe. The purpose was to identify and prioritise key activities for the next 5-10 years in the domains of clinical care, research, and advocacy and to create an action plan and performance framework based on ten themes: strengthen CKD surveillance; tackle major risk factors for CKD; reduce acute kidney injury-a special risk factor for CKD; enhance understanding of the genetic causes of CKD; establish better diagnostic methods in CKD; improve understanding of the natural course of CKD; assess and implement established treatment options in patients with CKD; improve management of symptoms and complications of CKD; develop novel therapeutic interventions to slow CKD progression and reduce CKD complications; and increase the quantity and quality of clinical trials in CKD...
April 20, 2017: Lancet
https://www.readbyqxmd.com/read/28363731/kidney-injury-and-repair-biomarkers-in-marathon-runners
#16
Sherry G Mansour, Gagan Verma, Rachel W Pata, Thomas G Martin, Mark A Perazella, Chirag R Parikh
BACKGROUND: Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation. STUDY DESIGN: Prospective observational study. SETTING & PARTICIPANTS: Runners participating in the 2015 Hartford Marathon. PREDICTOR: Completing a marathon. OUTCOMES: Acute kidney injury (AKI) as defined by AKI Network (AKIN) criteria. Stage 1 AKI was defined as 1...
August 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28356903/biomarkers-translational-medicine-and-drug-development-an-interview-with-chirag-r-parikh-md-phd
#17
Corey Horien
No abstract text is available yet for this article.
March 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28332475/association-of-urinary-uromodulin-with-kidney%C3%A2-function-decline-and-mortality-the%C3%A2-health-abc-study%C3%A2
#18
Pranav S Garimella, Ronit Katz, Joachim H Ix, Linda F Fried, Stephen B Kritchevsky, Prasad Devarajan, Michael R Bennett, Chirag R Parikh, Michael G Shlipak, Tamara B Harris, Orlando M Gutiérrez, Mark J Sarnak
BACKGROUND: Urine uromodulin (uUMOD) is a protein secreted by the kidney tubule. Recent studies have suggested that higher uUMOD may be associated with improved kidney and mortality outcomes. METHODS: Using a case-cohort design, we evaluated the association between baseline uUMOD levels and ≥ 30% estimated glomerular filtration rate (eGFR) decline, incident chronic kidney disease (CKD), rapid kidney function decline, and mortality using standard and modified Cox proportional hazards regression...
June 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28261998/use-of-a-targeted-urine-proteome-assay-tupa-to-identify-protein-biomarkers-of-delayed-recovery-after-kidney-transplant
#19
Kenneth R Williams, Christopher M Colangelo, Lin Hou, Lisa Chung, Justin M Belcher, Thomas Abbott, Isaac E Hall, Hongyu Zhao, Lloyd G Cantley, Chirag R Parikh
PURPOSE: Development of delayed graft function (DGF) following kidney transplant is associated with poor outcomes. An ability to rapidly identify patients with DGF versus those with immediate graft function (IGF) may facilitate the treatment of DGF and the research needed to improve prognosis. The purpose of this study was to use a Targeted Urine Proteome Assay to identify protein biomarkers of delayed recovery from kidney transplant. EXPERIMENTAL DESIGN: Potential biomarkers were identified using the Targeted Urine Proteome (MRM) Assay to interrogate the relative DGF/IGF levels of expression of 167 proteins in urine taken 12-18 h after kidney implantation from 21 DGF, 15 SGF (slow graft function), and 16 IGF patients...
July 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28223055/plasma-monocyte-chemotactic-protein-1-is-associated-with-acute-kidney-injury-and-death-after-cardiac-operations
#20
MULTICENTER STUDY
Dennis G Moledina, Selin Isguven, Eric McArthur, Heather Thiessen-Philbrook, Amit X Garg, Michael Shlipak, Richard Whitlock, Peter A Kavsak, Steven G Coca, Chirag R Parikh
BACKGROUND: Monocyte chemotactic protein-1 (MCP-1; chemokine C-C ligand-2 [CCL-2]) is upregulated in ischemia-reperfusion injury and is a promising biomarker of inflammation in cardiac operations. METHODS: We measured preoperative and postoperative plasma MCP-1 levels in adults undergoing cardiac operations to evaluate the association of perioperative MCP-1 levels with acute kidney injury (AKI) and death in Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI), a prospective, multicenter, observational cohort...
August 2017: Annals of Thoracic Surgery
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