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Chirag parikh

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https://www.readbyqxmd.com/read/28332475/association-of-urinary-uromodulin-with-kidney%C3%A2-function-decline-and-mortality-the%C3%A2-health-abc-study%C3%A2
#1
Pranav S Garimella, Ronit Katz, Joachim H Ix, Linda F Fried, Stephen B Kritchevsky, Prasad Devarajan, Michael R Bennett, Chirag R Parikh, Michael G Shlipak, Tamara B Harris, Orlando M Gutiérrez, Mark J Sarnak
BACKGROUND: Urine uromodulin (uUMOD) is a protein secreted by the kidney tubule. Recent studies have suggested that higher uUMOD may be associated with improved kidney and mortality outcomes. METHODS: Using a case-cohort design, we evaluated the association between baseline uUMOD levels and ≥ 30% estimated glomerular filtration rate (eGFR) decline, incident chronic kidney disease (CKD), rapid kidney function decline, and mortality using standard and modified Cox proportional hazards regression...
March 23, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28261998/use-of-a-targeted-urine-proteome-assay-tupa-to-identify-protein-biomarkers-of-delayed-recovery-after-kidney-transplant
#2
Kenneth R Williams, Christopher M Colangelo, Lin Hou, Lisa Chung, Justin M Belcher, Thomas Abbott, Isaac E Hall, Hongyu Zhao, Lloyd G Cantley, Chirag R Parikh
PURPOSE: Development of delayed graft function (DGF) following kidney transplant is associated with poor outcomes. An ability to rapidly identify patients with DGF versus those with immediate graft function (IGF) may facilitate the treatment of DGF and the research needed to improve prognosis. The purpose of this study was to use a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery from kidney transplant. EXPERIMENTAL DESIGN: Potential biomarkers were identified using the TUPA Multiple Reaction Monitoring (MRM) assay to interrogate the relative DGF/IGF levels of expression of 167 proteins in urine taken 12-18 hours after kidney implantation from 21 DGF, 15 SGF (slow graft function), and 16 IGF patients...
March 6, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28223055/plasma-monocyte-chemotactic-protein-1-is-associated-with-acute-kidney-injury-and-death-after-cardiac-operations
#3
Dennis G Moledina, Selin Isguven, Eric McArthur, Heather Thiessen-Philbrook, Amit X Garg, Michael Shlipak, Richard Whitlock, Peter A Kavsak, Steven G Coca, Chirag R Parikh
BACKGROUND: Monocyte chemotactic protein-1 (MCP-1; chemokine C-C ligand-2 [CCL-2]) is upregulated in ischemia-reperfusion injury and is a promising biomarker of inflammation in cardiac operations. METHODS: We measured preoperative and postoperative plasma MCP-1 levels in adults undergoing cardiac operations to evaluate the association of perioperative MCP-1 levels with acute kidney injury (AKI) and death in Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI), a prospective, multicenter, observational cohort...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28220028/perspective-on-clinical-application-of-biomarkers-in-aki
#4
Chirag R Parikh, Sherry G Mansour
Several biomarkers of renal injury have been identified but the utility of these biomarkers is largely confined to research studies, whereas widespread clinical applicability is limited. This is partly because the use of serum creatinine as the comparator has several limitations and restricts the full interpretation of biomarker performance. To highlight the potential for clinical application of biomarkers, the most pertinent biomarker data are summarized here, using clinically relevant scenarios in which biomarkers could assist with diagnostic and management dilemmas...
February 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28219345/biomarkers-for-the-detection-of-renal-fibrosis-and-prediction-of-renal-outcomes-a-systematic-review
#5
Sherry G Mansour, Jeremy Puthumana, Steven G Coca, Mark Gentry, Chirag R Parikh
BACKGROUND: Fibrosis is the unifying pathway leading to chronic kidney disease. Identifying biomarkers of fibrosis may help predict disease progression. METHODS: We performed a systematic review to evaluate the reliability of blood and urine biomarkers in identifying fibrosis on biopsy as well as predicting renal outcomes. Using MEDLINE and EMBASE, a two-stage search strategy was implemented. Stage I identified a library of biomarkers correlating with fibrosis on biopsy...
February 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28209095/leptospira-seropositivity-as-a-risk-factor-for-mesoamerican-nephropathy
#6
Alejandro Riefkohl, Oriana Ramírez-Rubio, Rebecca L Laws, Michael D McClean, Daniel E Weiner, James S Kaufman, Renee L Galloway, Sean V Shadomy, Marta Guerra, Juan José Amador, José Marcel Sánchez, Damaris López-Pilarte, Chirag R Parikh, Jessica H Leibler, Daniel R Brooks
BACKGROUND: Leptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers. OBJECTIVES: Investigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers. METHODS: In 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG)...
February 17, 2017: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28122032/approaches-to-predicting-outcomes-in-patients-with-acute-kidney-injury
#7
Danielle Saly, Alina Yang, Corey Triebwasser, Janice Oh, Qisi Sun, Jeffrey Testani, Chirag R Parikh, Joshua Bia, Aditya Biswas, Chess Stetson, Kris Chaisanguanthum, F Perry Wilson
Despite recognition that Acute Kidney Injury (AKI) leads to substantial increases in morbidity, mortality, and length of stay, accurate prognostication of these clinical events remains difficult. It remains unclear which approaches to variable selection and model building are most robust. We used data from a randomized trial of AKI alerting to develop time-updated prognostic models using stepwise regression compared to more advanced variable selection techniques. We randomly split data into training and validation cohorts...
2017: PloS One
https://www.readbyqxmd.com/read/28054933/association-of-hiv-infection-with-biomarkers-of-kidney-injury-and-fibrosis-in-the-multicenter-aids-cohort-study
#8
Vasantha Jotwani, Rebecca Scherzer, Michelle M Estrella, Lisa P Jacobson, Mallory D Witt, Frank Palella, Ken Ho, Michael Bennett, Chirag R Parikh, Joachim H Ix, Michael Shlipak
BACKGROUND: Chronic kidney disease (CKD) is common among HIV-infected individuals, but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men. METHODS: In this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP), and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study...
January 5, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28013112/urine-interleukin-18-and-lipocalin-2-are-biomarkers-of-acute-tubular-necrosis-in-patients-with-cirrhosis-a-systematic-review-and-meta-analysis
#9
Jeremy Puthumana, Xavier Ariza, Justin M Belcher, Isabel Graupera, Pere Ginès, Chirag R Parikh
BACKGROUND & AIMS: Acute kidney injury (AKI) is a common complication in patients with cirrhosis that increases mortality. The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome; it is important to determine the etiology of AKI to select the proper treatment and predict patient outcome. Urine biomarkers could be used to differentiate between patients with ATN and functional causes of AKI. We performed a systemic review and meta-analysis of published studies to determine whether urine levels of interleukin 18 (IL18) and lipocalin 2 (LCN2 or NGAL) associate with development of ATN in patients with cirrhosis...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27788160/storage-time-and-urine-biomarker-levels-in-the-assess-aki-study
#10
Kathleen D Liu, Edward D Siew, W Brian Reeves, Jonathan Himmelfarb, Alan S Go, Chi-Yuan Hsu, Michael R Bennett, Prasad Devarajan, T Alp Ikizler, James S Kaufman, Paul L Kimmel, Vernon M Chinchilli, Chirag R Parikh
BACKGROUND: Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. METHODS: 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study were included. Samples were processed under standard conditions and stored at -70°C until analyzed. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and liver fatty acid binding protein (L-FABP) were measured in urine samples collected during the index hospitalization or an outpatient visit 3 months later...
2016: PloS One
https://www.readbyqxmd.com/read/27759575/changes-in-urinary-biomarkers-over-10-years-is-associated-with-viral-suppression-in-a-prospective-cohort-of-women-living-with-hiv
#11
Sanjiv M Baxi, Rebecca Scherzer, Vasantha Jotwani, Michelle M Estrella, Alison G Abraham, Chirag R Parikh, Michael R Bennett, Mardge H Cohen, Marek J Nowicki, Deborah R Gustafson, Anjali Sharma, Mary A Young, Michael G Shlipak
BACKGROUND: Urine biomarkers have helped identify persons at risk for progressing to kidney disease in the setting of HIV infection. We explored factors associated with changes in 3 urine biomarkers over 10 years among women living with HIV. METHODS: Prospective cohort of 294 HIV-infected women from the multicenter Women's Interagency HIV Study. Predictors included HIV viral and immunological parameters, comorbid conditions, and health-related behaviors. Outcomes were patterns of changes of urine interleukin-18 (IL-18), albumin-to-creatinine ratio (ACR), and alpha-1-microglobulin (α1m) over 10 years...
April 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27618162/kidney-outcomes-5-years-after-pediatric-cardiac-surgery-the-tribe-aki-study
#12
Jason H Greenberg, Michael Zappitelli, Prasad Devarajan, Heather R Thiessen-Philbrook, Catherine Krawczeski, Simon Li, Amit X Garg, Steve Coca, Chirag R Parikh
Importance: Acute kidney injury (AKI) after pediatric cardiac surgery is associated with high short-term morbidity and mortality; however, the long-term kidney outcomes are unclear. Objective: To assess long-term kidney outcomes after pediatric cardiac surgery and to determine if perioperative AKI is associated with worse long-term kidney outcomes. Design, Setting, and Participants: This prospective multicenter cohort study recruited children between ages 1 month to 18 years who underwent cardiopulmonary bypass for cardiac surgery and survived hospitalization from 3 North American pediatric centers between July 2007 and December 2009...
November 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27576016/a-genome-wide-association-study-to-identify-single-nucleotide-polymorphisms-for-acute-kidney-injury
#13
Bixiao Zhao, Qiongshi Lu, Yuwei Cheng, Justin M Belcher, Edward D Siew, David E Leaf, Simon C Body, Amanda A Fox, Sushrut S Waikar, Charles D Collard, Heather Thiessen-Philbrook, T Alp Ikizler, Lorraine B Ware, Charles L Edelstein, Amit X Garg, Murim Choi, Jennifer A Schaub, Hongyu Zhao, Richard P Lifton, Chirag R Parikh
RATIONALE: Acute kidney injury is a common and severe complication of critical illness and cardiac surgery. Despite significant attempts at developing treatments, therapeutic advances to attenuate acute kidney injury and expedite recovery have largely failed. OBJECTIVES: Identifying genetic loci associated with increased risk of acute kidney injury may reveal novel pathways for therapeutic development. METHODS: We conducted an exploratory genome-wide association study to identify single-nucleotide polymorphisms associated with genetic susceptibility to in-hospital acute kidney injury...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27537050/first-post-operative-urinary-kidney-injury-biomarkers-and-association-with-the-duration-of-aki-in-the-tribe-aki-cohort
#14
Steven G Coca, Girish N Nadkarni, Amit X Garg, Jay Koyner, Heather Thiessen-Philbrook, Eric McArthur, Michael G Shlipak, Chirag R Parikh
BACKGROUND: We previously demonstrated that assessment of the duration of AKI, in addition to magnitude of rise in creatinine alone, adds prognostic information for long-term survival. We evaluated whether post-operative kidney injury biomarkers in urine collected immediately after cardiac surgery associate with duration of serum creatinine elevation. METHODS: We studied 1199 adults undergoing cardiac surgery in a prospective cohort study (TRIBE-AKI) and examined the association between the levels of five urinary biomarkers individually at 0-6 hours after surgery: interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver fatty acid binding protein (L-FABP) and albumin with duration of serum creatinine-based AKIN criteria for AKI (0 (no AKI), 1-2, 3-6, ≥7 days)...
2016: PloS One
https://www.readbyqxmd.com/read/27507113/hypochloremia-and-diuretic-resistance-in-heart-failure-mechanistic-insights
#15
Jennifer S Hanberg, Veena Rao, Jozine M Ter Maaten, Olga Laur, Meredith A Brisco, F Perry Wilson, Justin L Grodin, Mahlet Assefa, J Samuel Broughton, Noah J Planavsky, Tariq Ahmad, Lavanya Bellumkonda, W H Wilson Tang, Chirag R Parikh, Jeffrey M Testani
BACKGROUND: Recent epidemiological studies have implicated chloride, rather than sodium, as the driver of poor survival previously attributed to hyponatremia in heart failure. Accumulating basic science evidence has identified chloride as a critical factor in renal salt sensing. Our goal was to probe the physiology bridging this basic and epidemiological literature. METHODS AND RESULTS: Two heart failure cohorts were included: (1) observational: patients receiving loop diuretics at the Yale Transitional Care Center (N=162) and (2) interventional pilot: stable outpatients receiving ≥80 mg furosemide equivalents were studied before and after 3 days of 115 mmol/d supplemental lysine chloride (N=10)...
August 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27495761/delayed-graft-function-phenotypes-and-12-month-kidney-transplant-outcomes
#16
Isaac E Hall, Peter P Reese, Mona D Doshi, Francis L Weng, Bernd Schröppel, William S Asch, Joseph Ficek, Heather Thiessen-Philbrook, Chirag R Parikh
BACKGROUND: Ischemia-reperfusion injury (IRI) leading to delayed graft function, defined by the United Network for Organ Sharing as dialysis in the first week (UNOS-DGF), associates with poor kidney transplant outcomes. Controversies remain, however, about dialysis initiation thresholds and the utility for other criteria to denote less severe IRI, or slow graft function (SGF). METHODS: Multicenter, prospective study of deceased-donor kidney recipients to compare UNOS-DGF to a definition that combines impaired creatinine reduction in the first 48 hours or >1 dialysis session for predicting 12-month estimated glomerular filtration rate (eGFR)...
August 4, 2016: Transplantation
https://www.readbyqxmd.com/read/27490414/utility-of-applying-quality-assessment-tools-for-kidneys-with-kdpi-%C3%A2-80
#17
Mona D Doshi, Peter P Reese, Isaac E Hall, Bernd Schröppel, Joseph Ficek, Richard N Formica, Francis L Weng, Rick D Hazs, Heather Thiessen Philbrook, Chirag Parikh
BACKGROUND: Kidneys with "high" kidney donor profile index (KDPI) are often biopsied and pumped, yet frequently discarded. METHODS: In this multicenter study, we describe the characteristics and outcomes of kidneys with KDPI ≥80 that were procured from 338 deceased donors. We excluded donors with anatomical kidney abnormalities. RESULTS: Donors were categorized by the number of kidneys discarded: 1) none (n=154, 46%), 2) 1 discarded and 1 transplanted (n=48, 14%), 3) both discarded (n=136, 40%)...
August 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27451287/ykl-40-associates-with-renal-recovery-in-deceased-donor-kidney-transplantation
#18
Jeremy Puthumana, Isaac E Hall, Peter P Reese, Bernd Schröppel, Francis L Weng, Heather Thiessen-Philbrook, Mona D Doshi, Veena Rao, Chun Geun Lee, Jack A Elias, Lloyd G Cantley, Chirag R Parikh
Deceased donor kidneys with AKI are often discarded for fear of poor transplant outcomes. Donor biomarkers that predict post-transplant renal recovery could improve organ selection and reduce discard. We tested whether higher levels of donor urinary YKL-40, a repair phase protein, associate with improved recipient outcomes in a prospective cohort study involving deceased kidney donors from five organ procurement organizations. We measured urinary YKL-40 concentration in 1301 donors (111 had AKI, defined as doubling of serum creatinine) and ascertained outcomes in the corresponding 2435 recipients, 756 of whom experienced delayed graft function (DGF)...
February 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27374839/relevance-of-changes-in-serum-creatinine-during-a-heart-failure-trial-of-decongestive-strategies-insights-from-the-dose-trial
#19
Meredith A Brisco, Michael R Zile, Jennifer S Hanberg, F Perry Wilson, Chirag R Parikh, Steven G Coca, W H Wilson Tang, Jeffrey M Testani
BACKGROUND: Worsening renal function (WRF) is a common endpoint in decompensated heart failure clinical trials because of associations between WRF and adverse outcomes. However, WRF has not universally been identified as a poor prognostic sign, challenging the validity of WRF as a surrogate endpoint. Our aim was to describe the associations between changes in creatinine and adverse outcomes in a clinical trial of decongestive therapies. METHODS AND RESULTS: We investigated the association between changes in creatinine and the composite endpoint of death, rehospitalization or emergency room visit within 60 days in 301 patients in the Diuretic Optimization Strategies Evaluation (DOSE) trial...
October 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27319985/acute-kidney-injury-severity-and-long-term-readmission-and-mortality-after-cardiac-surgery
#20
Jeremiah R Brown, William M Hisey, Emily J Marshall, Donald S Likosky, Elizabeth L Nichols, Allen D Everett, Sara K Pasquali, Marshall L Jacobs, Jeff P Jacobs, Chirag R Parikh
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiac surgery. While AKI severity is known to be associated with increased risk of short-term outcomes, its long-term impact is less well understood. METHODS: Adult patients undergoing isolated coronary artery bypass graft surgery at eight centers were enrolled into the Northern New England biomarker registry (n = 1,610). Patients were excluded if they had renal failure (n = 15) or died during index admission (n = 38)...
November 2016: Annals of Thoracic Surgery
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