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JOURNAL ARTICLE
Serena D Souza, Wassim Obeid, Jeanine Hernandez, David Hu, Yumeng Wen, Dennis G Moledina, Andre Albert, Anya Gregg, Andrew Wheeler, Heather Thiessen Philbrook, Chirag R Parikh
Serum creatinine levels are insensitive to real-time changes in kidney function or injury. There is a growing interest in assessing kidney injury by measuring biomarkers in body fluid. From our previous studies, we identified and reported three urinary biomarkers namely Uromodulin (UMOD), Osteopontin (OPN), and Interleukin-9 (IL-9) to be associated with kidney health. The availability of a rapid point-of-care test for these urinary biomarkers will potentially accelerate its applicability and accessibility. In this study, we aimed to develop novel lateral flow device (LFD) for UMOD, OPN and IL-9...
April 12, 2024: Scientific Reports
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JOURNAL ARTICLE
Chirag R Parikh, Steven G Coca
No abstract text is available yet for this article.
April 2024: Kidney International
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JOURNAL ARTICLE
Jaymin Parikh, Keyur Bhatt, Krunal Modi, Ajay Desai, Nihal Patel, Chirag Patel, Ravibhai Bhola
The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing out the fluorescence study with selected antibiotics, we observed remarkable enhancement of fluorescence spectra in the presence of ciprofloxacin, singling out the PCACP_Ciprofloxacin complex. The detailed binding mechanism is explored via computational methods including molecular docking and dynamics, DFT (density functional theory) and NBO (Natural Bonding Orbital) analysis...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
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JOURNAL ARTICLE
Dennis G Moledina, Wassim Obeid, Rex N Smith, Ivy Rosales, Meghan E Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A Perazella, Randy L Luciano, Jordan S Pober, Lloyd G Cantley, Robert B Colvin, F Perry Wilson, Chirag R Parikh
No abstract text is available yet for this article.
March 15, 2024: Journal of Clinical Investigation
#5
JOURNAL ARTICLE
Vasantha Jotwani, Stephanie Y Yang, Heather Thiessen-Philbrook, Chirag R Parikh, Ronit Katz, Gregory J Tranah, Joachim H Ix, Steve Cummings, Sushrut S Waikar, Michael G Shlipak, Mark J Sarnak, Samir M Parikh, Dan E Arking
Experimental models suggest an important role for mitochondrial dysfunction in the pathogenesis of chronic kidney disease (CKD) and acute kidney injury (AKI), but little is known regarding the impact of common mitochondrial genetic variation on kidney health. We sought to evaluate associations of inherited mitochondrial DNA (mtDNA) variation with risk of CKD and AKI in a large population-based cohort. We categorized UK Biobank participants who self-identified as white into eight distinct mtDNA haplotypes, which were previously identified based on their associations with phenotypes associated with mitochondrial DNA copy number, a measure of mitochondrial function...
February 13, 2024: Human Genetics
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JOURNAL ARTICLE
Sonal Pande, Chirag A Patel, Tejas M Dhameliya, Jayesh Beladiya, Palak Parikh, Radhika Kachhadiya, Sandip Dholakia
UNLABELLED: Uridine 5'-diphospho-glucuronosyltransferases (UGTs) have been considered as a family of enzymes responsible for the glucuronidation process, a crucial phase II detoxification reaction. Among the various UGT isoforms, UGTs A10 and B7 have garnered significant attention due to their broad substrate specificity and involvement in the metabolism of numerous compounds. Recent studies have suggested that certain vitamins may exert inhibitory effects on UGT activity, thereby influencing the metabolism of drugs, environmental toxins, and endogenous substances, ultimately impacting their biological activities...
2024: In Silico Pharmacology
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JOURNAL ARTICLE
Dipal M Patel, Bryce M Churilla, Heather Thiessen-Philbrook, Yingying Sang, Morgan E Grams, Chirag R Parikh, Deidra C Crews
INTRODUCTION: The kidney failure risk equation (KFRE) estimates a person's risk of kidney failure and has great potential utility in clinical care. METHODS: We used mixed methods to explore implementation of the KFRE in nephrology clinics. RESULTS: KFRE scores were integrated into the electronic health record at Johns Hopkins Medicine and were displayed to nephrology providers. Documentation of KFRE scores increased over time, reaching 25% of eligible outpatient nephrology clinic notes at month 11...
December 2023: KI Reports
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JOURNAL ARTICLE
Yumeng Wen, Emily Su, Leyuan Xu, Steven Menez, Dennis G Moledina, Wassim Obeid, Paul M Palevsky, Sherry G Mansour, Prasad Devarajan, Lloyd G Cantley, Patrick Cahan, Chirag R Parikh
Acute kidney injury (AKI) is a major risk factor for long-term adverse outcomes, including chronic kidney disease. In mouse models of AKI, maladaptive repair of the injured proximal tubule (PT) prevents complete tissue recovery. However, evidence for PT maladaptation and its etiological relationship with complications of AKI is lacking in humans. We performed single-nucleus RNA sequencing of 120,985 nuclei in kidneys from 17 participants with AKI and seven healthy controls from the Kidney Precision Medicine Project...
December 13, 2023: Science Translational Medicine
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Reetika Ghag, Madhurima Kaushal, Gerald Nwanne, Amanda Knoten, Krzysztof Kiryluk, Avi Rosenberg, Steve Menez, Serena M Bagnasco, C John Sperati, Mohamed G Atta, Joseph P Gaut, James C Williams, Tarek M El-Achkar, Lois J Arend, Chirag R Parikh, Sanjay Jain
UNLABELLED: Acute kidney injury (AKI) in COVID-19 patients is associated with high mortality and morbidity. Critically ill COVID-19 patients are at twice the risk of in-hospital mortality compared to non-COVID AKI patients. We know little about the cell-specific mechanism in the kidney that contributes to worse clinical outcomes in these patients. New generation single cell technologies have the potential to provide insights into physiological states and molecular mechanisms in COVID-AKI...
November 12, 2023: bioRxiv
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JOURNAL ARTICLE
Nihal Patel, Krunal Modi, Keyur Bhatt, Jaymin Parikh, Ajay Desai, Bhavesh Jain, Nirali Parmar, Chirag N Patel, Alan Liska, Jiri Ludvik, Shibu Pillai, Brij Mohan
The detection of trace amounts of sulfosulfuron, a pesticide of increasing importance, has become a pressing issue, prompting the development of effective chemosensors. In this study, we functionalized cyclotricatechylene (CTC) with propyl-phthalimide due to the presence of electronegative oxygen and nitrogen binding sites. Our optimized ligand displayed the highest docking score with sulfosulfuron, and experimental studies confirmed a significant fluorescence enhancement upon its interaction with sulfosulfuron...
November 7, 2023: ACS Omega
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EDITORIAL
Sanjeev Noel, Chirag R Parikh
No abstract text is available yet for this article.
December 1, 2023: American Journal of Physiology. Renal Physiology
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JOURNAL ARTICLE
Mason Lai, Erin Madden, Michael G Shlipak, Rebecca Scherzer, Wendy S Post, Eric Vittinghoff, Sabina Haberlen, Todd T Brown, Steven M Wolinsky, Mallory D Witt, Ken Ho, Alison G Abraham, Chirag R Parikh, Matthew Budoff, Michelle M Estrella
OBJECTIVE: To determine whether urine biomarkers of kidney health are associated with subclinical cardiovascular disease among men living with and without HIV. DESIGN: Cross-sectional study within the Multicenter AIDS Cohort Study (MACS) among 504 men with and without HIV infection who underwent cardiac computed tomography scans and had urine biomarkers measured within the preceding two years. METHODS: Our primary predictors were four urine biomarkers of endothelial (albuminuria), proximal tubule dysfunction (alpha-1-microglobulin [A1 M] and injury (kidney injury molecule-1 [KIM-1]) and tubulointerstitial fibrosis (pro-collagen-III N-terminal peptide [PIIINP])...
October 20, 2023: AIDS
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JOURNAL ARTICLE
Dustin Le, Jingsha Chen, Michael G Shlipak, Joachim H Ix, Mark J Sarnak, Orlando M Gutierrez, Jeffrey R Schelling, Joseph V Bonventre, Venkata S Sabbisetti, Sarah J Schrauben, Steven G Coca, Paul L Kimmel, Ramachandran S Vasan, Morgan E Grams, Chirag Parikh, Josef Coresh, Casey M Rebholz
RATIONALE & OBJECTIVE: Biomarkers of kidney disease progression have been identified in individuals with diabetes and underlying chronic kidney disease (CKD). Whether or not these markers are associated with the development of CKD in a general population without diabetes or CKD is not well established. STUDY DESIGN: Prospective observational cohort. SETTING & PARTICIPANTS: In the Atherosclerosis Risk in Communities) study, 948 participants were studied...
November 2023: Kidney medicine
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JOURNAL ARTICLE
Elizabeth A Kiernan, David Hu, Heather Thiessen Philbrook, Joachim H Ix, Joseph V Bonventre, Steven G Coca, Dennis G Moledina, Linda F Fried, Michael G Shlipak, Chirag R Parikh
RATIONALE & OBJECTIVE: Urinary biomarkers of injury, inflammation, and repair may help phenotype acute kidney injury (AKI) observed in clinical trials. We evaluated the differences in biomarkers between participants randomized to monotherapy or to combination renin-angiotensin-aldosterone system (RAAS) blockade in VA NEPHRON-D, where an increased proportion of observed AKI was acknowledged in the combination arm. STUDY DESIGN: Longitudinal analysis. SETTING & PARTICIPANTS: A substudy of the VA NEPHRON-D trial...
February 2024: American Journal of Kidney Diseases
#15
JOURNAL ARTICLE
Teresa K Chen, Michelle M Estrella, Lawrence J Appel, Aditya L Surapaneni, Anna Köttgen, Wassim Obeid, Chirag R Parikh, Morgan E Grams
RATIONALE & OBJECTIVE: Uromodulin (UMOD) is the most abundant protein found in urine and has emerged as a promising biomarker of tubule health. Circulating UMOD is also detectable, but at lower levels. We evaluated whether serum UMOD levels were associated with the risks of incident kidney failure with replacement therapy (KFRT) and mortality. STUDY DESIGN: Prospective cohort. SETTING & PARTICIPANTS: Participants in AASK (the African American Study of Kidney Disease and Hypertension) with available stored serum samples from the 0-, 12-, and 24-month visits for biomarker measurement...
January 2024: American Journal of Kidney Diseases
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MULTICENTER STUDY
Steven Menez, Yumeng Wen, Leyuan Xu, Dennis G Moledina, Heather Thiessen-Philbrook, David Hu, Wassim Obeid, Pavan K Bhatraju, T Alp Ikizler, Edward D Siew, Vernon M Chinchilli, Amit X Garg, Alan S Go, Kathleen D Liu, James S Kaufman, Paul L Kimmel, Jonathan Himmelfarb, Steven G Coca, Lloyd G Cantley, Chirag R Parikh
Biomarkers of tubular function such as epidermal growth factor (EGF) may improve prognostication of participants at highest risk for chronic kidney disease (CKD) after hospitalization. To examine this, we measured urinary EGF (uEGF) from samples collected in the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study, a multi-center, prospective, observational cohort of hospitalized participants with and without AKI. Cox proportional hazards regression was used to investigate the association of uEGF/Cr at hospitalization, three months post-discharge, and the change between these time points with major adverse kidney events (MAKE): CKD incidence, progression, or development of kidney failure...
December 2023: Kidney International
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JOURNAL ARTICLE
Mason Lai, Rebecca Scherzer, Michael G Shlipak, Erin Madden, Eric Vittinghoff, Warren Tse, Chirag R Parikh, Celia P Corona Villalobos, Jose Manuel Monroy-Trujillo, Richard D Moore, Michelle M Estrella
BACKGROUND: People living with HIV (PLWH) generally have worse ambulatory levels of kidney injury biomarkers and excess risk of acute kidney injury (AKI) compared to persons without HIV. We evaluated whether ambulatory measures of subclinical kidney injury among PLWH are associated with subsequent AKI. METHODS: In the Predictors of Acute Renal Injury Study (PARIS), which enrolled 468 PLWH from April 2016 to August 2019, we measured 10 urine biomarkers of kidney health (albumin, a1m, b2 M, NGAL, IL18, KIM-1, EGF, UMOD, MCP-1, YKL40) at baseline and annually during follow-up...
August 25, 2023: AIDS
#18
JOURNAL ARTICLE
George Vasquez-Rios, Ronit Katz, Emily B Levitan, Mary Cushman, Chirag R Parikh, Paul L Kimmel, Joseph V Bonventre, Sushrut S Waikar, Sarah J Schrauben, Jason H Greenberg, Mark J Sarnak, Joachim H Ix, Michael G Shlipak, Orlando M Gutierrez
BACKGROUND: Kidney disease assessed by serum creatinine and albuminuria are strongly associated with mortality in diabetes. These markers primarily reflect glomerular function and injury. Urine biomarkers of kidney tubule health were recently associated with the risk of kidney failure in individuals with chronic kidney disease (CKD) and diabetes. Associations of these biomarkers with risk of death are poorly understood. METHODS: In 560 individuals with diabetes and estimated glomerular filtration rate (eGFR) ≤60 ml/min/1...
August 3, 2023: Kidney360
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JOURNAL ARTICLE
Blue B Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian Kalhor, Daria Barwinska, Edgar A Otto, Michael Ferkowicz, Dinh Diep, Nongluk Plongthongkum, Amanda Knoten, Sarah Urata, Laura H Mariani, Abhijit S Naik, Sean Eddy, Bo Zhang, Yan Wu, Diane Salamon, James C Williams, Xin Wang, Karol S Balderrama, Paul J Hoover, Evan Murray, Jamie L Marshall, Teia Noel, Anitha Vijayan, Austin Hartman, Fei Chen, Sushrut S Waikar, Sylvia E Rosas, Francis P Wilson, Paul M Palevsky, Krzysztof Kiryluk, John R Sedor, Robert D Toto, Chirag R Parikh, Eric H Kim, Rahul Satija, Anna Greka, Evan Z Macosko, Peter V Kharchenko, Joseph P Gaut, Jeffrey B Hodgin, Michael T Eadon, Pierre C Dagher, Tarek M El-Achkar, Kun Zhang, Matthias Kretzler, Sanjay Jain
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods1 . Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main cell types, which include rare and previously undescribed cell populations...
July 2023: Nature
#20
JOURNAL ARTICLE
Amit X Garg, Meaghan Cuerden, Juan Cata, Matthew T V Chan, P J Devereaux, Edith Fleischmann, Ascensión Martín Grande, Barbara Kabon, Giovanni Landoni, Donna E Maziak, Sean McLean, Chirag Parikh, Ekaterine Popova, Cara Reimer, Juan Carlos Trujillo Reyes, Pavel Roshanov, Daniel I Sessler, Sadeesh Srinathan, Jessica M Sontrop, Anna Gonzalez Tallada, Michael Ke Wang, Jennifer R Wells, David Conen
BACKGROUND: Inflammation during and after surgery can lead to organ damage including acute kidney injury. Colchicine, an established inexpensive anti-inflammatory medication, may help to protect the organs from pro-inflammatory damage. This protocol describes a kidney substudy of the colchicine for the prevention of perioperative atrial fibrillation (COP-AF) study, which is testing the effect of colchicine versus placebo on the risk of atrial fibrillation and myocardial injury among patients undergoing thoracic surgery...
2023: Canadian Journal of Kidney Health and Disease
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