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Rishi Pruthi, Mark McClure, Anna Casula, Paul J Roderick, Damian Fogarty, Mark Harber, Rommel Ravanan
Glomerulonephritis (GN) is the primary diagnosis in 20% to 40% of patients receiving a renal transplant. Here we studied patient survival and graft outcomes in patients with GN transplanted in the UK. UK Renal Registry data were used to analyze patient survival and graft failure in incident transplant patients between 1997 to 2009 who had a diagnosis of primary GN, in comparison to patients transplanted with adult polycystic kidney disease (APKD) or diabetes. Multivariable regression analysis adjusted for age, sex, donor type, ethnicity, donor age, time on dialysis, human leukocyte antigen mismatch, cold ischemic time, and graft failure (for patient survival)...
April 2016: Kidney International
Sarwat B Ahmad, Brian Inouye, Michael S Phelan, Andrew C Kramer, Jay Sulek, Matthew R Weir, Rolf N Barth, John C LaMattina, Eugene J Schweitzer, David B Leeser, Silke V Niederhaus, Stephen T Bartlett, Jonathan S Bromberg
BACKGROUND: Timing of bilateral nephrectomy (BN) is controversial in patients with refractory symptoms of autosomal dominant polycystic kidney disease (APKD) in need of a renal transplant. METHODS: Adults who underwent live donor renal transplant (LRT) + simultaneous BN (SBN) from August 2003 to 2013 at a single transplant center (n = 66) were retrospectively compared to a matched group of APKD patients who underwent LRT alone (n = 52). All patients received general health and polycystic kidney symptom surveys...
February 2016: Transplantation
Pcn Okere, S N Ezeofor, N I Iloanusi, P O Ibinaiye, I J Okoye
BACKGROUND: Autosomal dominant polycystic kidney disease (APKD), an inheritable multisystem disease characterized by intrarenal and at times extrarenal disease, has been studied extensively among Caucasian populations. Despite the fact that being black is a risk factor for progressive disease, there is paucity of local published data. As a result, true local incidence and peculiarities in clinical and sonographic characteristics are unknown. AIM: To present data from 19 patients diagnosed with APKD in a medium-sized facility over a 16-year period...
March 2015: Nigerian Journal of Clinical Practice
Adam Williamson, Sureyya Paterson, Caroline Erolin, Clare Sweeney, Nicholas Townell, Ghulam Nabi
BACKGROUND AND PURPOSE: Indications for laparoscopic renal surgery are increasing; however, benefits in adult polycystic kidney disease (APKD) remain uncertain. Our objective was to systematically synthesize the reported literature on safety, feasibility, complications, and early outcomes of laparoscopic nephrectomy in APKD to determine clinical benefits for surgical practice. METHODS: We conducted a meta-analysis of the published literature reporting on laparoscopic nephrectomy in APKD between 1991 and 2013...
November 2014: Journal of Endourology
Rodrigo Nazário Leão, Raquel Salustio, José Vaz Ribeiro
A widespread use of ultrasound (US) examination is contributing to an increase in the diagnosis of renal and hepatic cysts. However, the vast majority of these lesions are benign with an indolent course during the patient's lifespan. Adult polycystic kidney disease (APKD) is one of the most common diagnosed entities. APKD is a genetic disease defined by the presence of multiple kidney cysts, occasionally accompanied by hepatic cysts. The presence of hepatic cysts sparing kidneys is very rare and thereby must be assumed as a different clinical entity...
January 17, 2014: BMJ Case Reports
Qijun Wan, Yongcheng He, Wanfan Zhang, Qiang Wu, Zibo Xiong
BACKGROUND: Some chronic hemodialysis (HD) patients can maintain normal hemoglobin levels without requiring erythropoiesis-stimulating agents (ESAs). However, the prevalence and the factors associated with this condition in Chinese chronic HD patients have not been reported. The aim of this study was to investigate clinical features, iron metabolism, and other characteristics to survey the prevalence rate and the related factors of this condition among Chinese chronic HD patients. METHODS: A total of 1,318 chronic HD patients participated in this study...
August 2014: International Urology and Nephrology
Robert Ekart, Anita Ferjuc, Barbara Furman, Špela Gerjevič, Sebastjan Bevc, Radovan Hojs
Chronic kidney disease (CKD) is common and several factors affect its progression to end-stage renal disease (ESRD). The main goal of our study was to assess the influence of underlying kidney disease and some other important factors during the time of CKD progression to ESRD. A retrospective study of 91 patients (57 men, 34 women; average age 57.7 ± 13.2 years) was carried out. Patients were monitored at least one month before the first renal replacement treatment (RRT). Estimated glomerular filtration rate (eGFR) at first referral to nephrologist was determined by Modification of Diet in Renal Disease equation...
August 2013: Therapeutic Apheresis and Dialysis
Fiona Wu, Zhaolong Deng, David Consigliere, Ho Yee Tiong
Adult polycystic kidney disease (APKD) accounts for 2% of end-stage renal disease in Singapore and is a major indication for kidney transplantation. We report synchronous nephrectomy with unilateral cadaveric dual kidney transplantation (DKT) in a patient with APKD. Simple nephrectomy of the right native 27-cm polycystic kidney was performed to provide adequate space for unilateral DKT. Right donor kidney transplantation was performed at the site of native nephrectomy. End-to-side anastomosis of the right donor renal vein to the distal inferior vena cava and the right donor artery to the common iliac artery were performed...
August 2012: Singapore Medical Journal
J Malyszko, J S Malyszko, N Levin-Iaina, E Koc-Zorawska, P Kozminski, M Mysliwiec
INTRODUCTION: Hemojuvelin (HJV) is highly expressed in the liver, skeletal muscles, and heart, seems to play a role in iron absorption and release from cells, and has anti-inflammatory properties. Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway. Hepcidin has emerged as a key regulator of iron homeostasis. In this study we tested for the first time the hypothesis that HJV is related to iron metabolism in hemodialysis (HD) patients...
December 2012: International Urology and Nephrology
P Kanagarajah, R Ayyathurai, C M Lynne
Adult polycystic kidney disease (APKD) is one of the most common inherited disorders affecting one in 800-1000 live births. Extra-renal manifestation of APKD is not uncommon. Cysts involving the male and female reproductive system have been reported. However, fertility is affected only in male subjects. Among cysts involving the reproductive system, seminal vesicle cysts have been reported to be the most common. The effect of seminal vesicle cysts on male fertility has been controversial. Current literature reports that majority of men remain fertile...
May 2012: Andrologia
Ursula Verdalles, Soraya Abad, Almudena Vega, Caridad Ruiz Caro, Jara Ampuero, Rosa Jofre, Juan Manuel Lopez-Gomez
BACKGROUND: A small number of hemodialysis (HD) patients have normal hemoglobin (Hb) levels without the need for erythropoiesis-stimulating agents (ESAs). The factors associated with this condition have been little studied. The objective of this prospective study was to determine these factors in a prevalent population of HD patients. MATERIALS AND METHODS: All patients who had normal Hb levels and who had not received ESAs in the last 6 months (non-ESA group) were included...
2011: Blood Purification
P M Bath, A K Saggar-Malik, I C Macdougall, J B Eastwood, G A Macgregor
Platelet volume is a measure of platelet function. An increased platelet volume is found in acute vascular syndromes and may have a causative role and predict outcome. Patients with autosomal dominant polycystic kidney disease (APKD) are at increased risk of developing, and dying from, premature vascular disease. We hypothesized that platelet volume might be altered in patients with APKD. Platelet volume was measured in 16 normotensive APKD patients with normal renal function and 16 normal volunteers pair-matched for age, gender, race and body mass index...
1995: Platelets
Visnja Lezaić, Vladimir Ostrić, Gordana Popović, Milja Vukoje, Branislava Dragolić, Nevena Kostić, Marina Stojanović, Milorad Labudović, Milan Mandić, Verica Djordjević, Jovan Baković
INTRODUCTION: Adult polycystic kidney disease (APKD) is the most common hereditary kidney disease in humans. The course of the disease is accompanied by numerous complications. OBJECTIVE The aim was to assess the prevalence, clinical course and outcome of adult dominant polycystic kidney disease (ADPKD) patients on renal replacement therapy. METHOD: Medical data on 700 haemodialyzed (HD) and 500 transplanted patients treated in 10 Serbian centres from 1996 to 2000 were retrospectively analyzed...
December 2008: Srpski Arhiv za Celokupno Lekarstvo
Chao-wen Yu, Si-zhong Zhang
Adult polycystic kidney disease (APKD) is a severe autosomal dominant inheritable renal disease with high incidence. Because of the late-onset of the disease, patients might have transferred the disease gene to the next generation when diagnosis is made. Since its pathogenic molecular mechanism is still not completely clear and the shortage of effective medicines, the prevention and treatment of the disease is still not satisfactory. In the present article, the recent advances in the research on the pathogenesis, gene diagnosis and management of APKD are reviewed...
August 2010: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
C Puliatti, M R Stephens, J Kenche, M Ilham, N Kumar, A Asderakis
Occult infection following renal transplantation is a common diagnostic problem facing nephrologists and transplant surgeons. Patients with adult polycystic kidney disease (APKD) are prone to recurrent infections in their native kidneys and this can present with little if any localizing signs. Conventional radiological imaging with computed tomography or ultrasonography has a low sensitivity and specificity in such patients due to anatomic distortion and poor native renal function, and therefore identifying the source of sepsis can be difficult...
July 2007: Transplantation Proceedings
Hui Li, Tong Liu, Chuan Liu, Tao Shang
OBJECTIVE: To study the prenatal diagnosis and clinical significance of fetal hyperechogenic kidneys. METHODS: Thirty one cases with fetal hyperechogenic kidneys were prenatally diagnosed with ultrasound. Autopsy was conducted and histological examination of the kidney was performed when pregnancy was terminated. A close follow-up was given for cases continuing pregnancy. Umbilical cord blood was collected for fetal chromosome analysis after delivery. RESULTS: (1) 6 fetuses were complicated with other organ abnormalities, 3 fetuses had abnormal chromosome, and 2 cases had a family history...
April 2007: Zhonghua Fu Chan Ke za Zhi
Kleber Simões do Espírito Santo, Vicente de Paulo Castro Teixeira, Henrique de Oliveira Costa, Marcello Franco
Adult polycystic kidney disease (APKD) is a common and potentially fatal disease, leading to end-stage renal failure in 50% of cases. The disease is frequently complicated by arterial hypertension, bacterial pyelonephritis, and hematuria. The association between APKD and tuberculosis has rarely been reported and is related to a more unfavorable course since the infection becomes refractory to specific treatment. The authors report 2 cases of renal tuberculosis diagnosed in the native nephrectomy specimens of 2 patients with APKD after renal transplantation...
April 2007: International Journal of Surgical Pathology
Kim L Wang, David M Weinrach, Chunyan Luan, Misop Han, Fan Lin, Bin T Teh, Ximing J Yang
The precursor lesions of renal cell carcinoma (RCC) are unknown. The purpose of this study is to determine the incidence, histomorphological features, and immunohistochemical features of papillary adenoma and elucidate its potential relationship to RCC. We reviewed 542 consecutive nephrectomy specimens over an 8-year period. Immunohistochemistry was carried out with antibodies specific for alpha-methyl-coenzyme A racemase (AMACR) and glutathione S-transferase alpha (clear-cell RCC marker). Thirty-eight (7%) nephrectomy specimens showed histologic evidence of papillary adenoma...
February 2007: Human Pathology
M Tobias-Machado, Alessandro Tavares, Pedro H Forseto, Joao P Zambon, Roberto V Juliano, Eric R Wroclawski
INTRODUCTION: We describe our experience with hand-assisted laparoscopy (HAL) as an option for the treatment of large renal specimens. MATERIALS AND METHODS: Between March 2000 and August 2004, 13 patients candidate to nephrectomies due to benign renal conditions with kidneys larger than 20 cm were included in a prospective protocol. Unilateral nephrectomy was performed in cases of hydronephrosis (6 patients) or giant pyonephrosis (4 patients). Bilateral nephrectomy was performed in 3 patients with adult polycystic kidney disease (APKD) with low back pain refractory to clinical treatment previous to kidney transplant...
November 2005: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Massimo Manno, Emanuela Marchesan, Francesco Tomei, Daniele Cicutto, Daniele Maruzzi, Anna Maieron, Alberto Turco
Adult polycystic kidney disease (APKD) is a frequent disease (1/1000) responsible for about 10% of chronic renal failure. It is an autosomic dominant disease due to mutation of one out of three genes: PKD1 (on the 16th chromosome), PKD2 (on the 4th chromosome) and PKD3 (still unmapped). In the past APKD diagnosis was normally done in fourteen-fifteen years old subjects who have completed their reproductive program. However frequently today, after renal ultrasound introduction, the APKD diagnosis is made during reproductive life...
March 2005: Archivio Italiano di Urologia, Andrologia
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