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https://www.readbyqxmd.com/read/28913495/improvement-of-recovery-parameters-using-patient-controlled-epidural-analgesia-after-oncological-surgery-a-prospective-randomized-single-center-study
#1
Armeana Olimpia Zgâia, Cosmin Ioan Lisencu, Alexandru Rogobete, Cătălin Vlad, Patriciu Achimaş-Cadariu, Gabriel Lazăr, Maximilian Muntean, Florin Ignat, Vlad Ormindean, Alexandru Irimie
PURPOSE: The aim of this study was to compare patient-controlled epidural analgesia (PCEA) versus conventional opioid intravenous (IV) infusion after gastrointestinal cancer surgery regarding several post-surgery parameters of recovery. METHODS: One hundred and one patients were prospectively randomized to receive either thoracic/lumbar PCEA (PCEA group) or the standard analgesia technique used in our hospital, conventional IV infusion of morphine (IVMO group) after gastrointestinal cancer surgery...
April 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28913485/an-in-vitro-study-of-the-release-capacity-of-the-local-anaesthetics-from-siloxane-matrices
#2
Gabriela Preda, Alexandru Florin Rogobete, Dorel Săndesc, Ovidiu Horea Bedreag, Carmen Alina Cradigati, Mirela Sarandan, Marius Papurica, Sonia Elena Popovici, Monica Dragomirescu
AIMS: In the field of anaesthesia and intensive care, the controlled release systems capable of delivering constantly local anaesthetics are of interest because of the advantages brought to pain management. In this paper we presented the release profiles by usage of siloxane matrices of two common local anaesthetics, lidocaine and bupivacaine, analysed in vitro. METHODS: The siloxane matrices were obtained in accordance with the methods described in the specialized literature, tetraethoxysilane (TEOS) and tetramethoxysilane (TMOS) were used as precursors...
October 2016: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28910075/mechanochemical-synthesis-of-pedot-pss-hydrogels-for-aqueous-formulation-of-li-ion-battery-electrodes
#3
Georgiana Sandu, Bruno Ernould, Julien Rolland, Nathalie Cheminet, Jeremy Brassinne, Pratik Das, Yaroslav Filinchuk, Luhua Cheng, Lidiya Komsiyska, Philippe Dubois, Sorin Melinte, Jean-François Gohy, Roberto Lazzaroni, Alexandru Vlad
Water-soluble binders can enable greener and cost effective Li-ion battery manufacturing by eliminating the standard fluorine-based formulations and associated organic solvents. The issue with water-based dispersions, however, remains the difficulty to stabilize them, requiring additional processing complexity. Herein, we show that mechanochemical conversion of a regular poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) water-based dispersion produces a hydrogel that meets all the requirements as binder for lithium-ion battery electrode manufacture...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28905052/cyclic-peptide-production-using-a-macrocyclase-with-enhanced-substrate-promiscuity-and-relaxed-recognition-determinants
#4
Cristina N Alexandru-Crivac, Christian Umeobika, Niina Leikoski, Jouni Jokela, Kirstie A Rickaby, André M Grilo, Peter Sjö, Alleyn T Plowright, Mohannad Idress, Eike Siebs, Ada Nneoyi-Egbe, Matti Wahlsten, Kaarina Sivonen, Marcel Jaspars, Laurent Trembleau, David P Fewer, Wael E Houssen
Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6-11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.
September 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28904183/the-tb-portals-an-open-access-web-based-platform-for-global-drug-resistant-tuberculosis-data-sharing-and-analysis
#5
Alex Rosenthal, Andrei Gabrielian, Eric Engle, Darrell E Hurt, Sofia Alexandru, Valeriu Crudu, Eugene Sergueev, Valery Kirichenko, Vladzimir Lapitskii, Eduard Snezhko, Vassili Kovalev, Andrei Astrovko, Alena Skrahina, Jessica Taaffe, Michael Harris, Alyssa Long, Kurt Wollenberg, Irada Akhundova, Sharafat Ismayilova, Aliaksandr Skrahin, Elcan Mammadbayov, Hagigat Gadirova, Rafik Abuzarov, Mehriban Seyfaddinova, Zaza Avaliani, Irina Strambu, Dragos Zaharia, Alexandru Muntean, Eugenia Ghita, Miron Bogdan, Roxana Mindru, Victor Spinu, Alexandra Sora, Catalina Ene, Sergo Vashakidze, Natalia Shubladze, Ucha Nanava, Alexander Tuzikov, Michael Tartakovsky
The TB Portals Program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and IT professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis and backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), of which 976 (75...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28903425/pasireotide-is-more-effective-than-octreotide-alone-or-combined-with-everolimus-on-human-meningioma-in-vitro
#6
Thomas Graillon, David Romano, Céline Defilles, Christophe Lisbonis, Alexandru Saveanu, Dominique Figarella-Branger, Pierre-Hugues Roche, Stéphane Fuentes, Olivier Chinot, Henry Dufour, Anne Barlier
Pasireotide is a somatostatin analog (SSA) that targets somatostatin receptor subtype 1 (SST1), SST2, SST3, and SST5 with a high affinity. Pasireotide has a better antisecretory effect in acromegaly, Cushing's disease, and neuroendocrine tumors than octreotide. In this study, we compared the effects of pasireotide to those of octreotide in vitro on meningioma primary cell cultures, both alone and in combination with the mTOR inhibitor everolimus. Significant mRNA expression levels of SST1, SST2, and SST5 were observed in 40...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28898885/pilot-neonatal-screening-program-for-central-congenital-hypothyroidism-evidence-of-significant-detection
#7
Débora Braslavsky, Maria Virginia Méndez, Laura Prieto, Ana Keselman, Rosa Enacan, Laura Gruñeiro-Papendieck, Nicolas Jullien, Alexandru Savenau, Rachel Reynaud, Thierry Brue, Ignacio Bergadá, Ana Chiesa
BACKGROUND/AIM: Congenital hypothyroidism (CH) is a heterogeneous entity. Neonatal screening programs based on thyrotropin (TSH) determination allow primary CH diagnosis but miss central CH (CCH). CCH causes morbidity, alerts to other pituitary deficiencies, and is more prevalent than previously thought. We aimed at developing a pilot neonatal screening program for CCH detection. PATIENTS AND METHODS: A prospective 2-year pilot neonatal screening study based on simultaneous dried blood specimen TSH and thyroxine (T4) measurements was implemented in term newborns aged 2-7 days...
September 12, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28894379/mirna-expression-profiling-in-formalin-fixed-paraffin-embedded-endometriosis-and-ovarian-cancer-samples
#8
Ovidiu-Leonard Braicu, Liviuta Budisan, Rares Buiga, Ancuta Jurj, Patriciu Achimas-Cadariu, Laura Ancuta Pop, Cornelia Braicu, Alexandru Irimie, Ioana Berindan-Neagoe
Endometriosis is an inflammatory pathology associated with a negative effect on life quality. Recently, this pathology was connected to ovarian cancer, in particular with endometrioid ovarian cancer. microRNAs (miRNAs) are a class of RNA transcripts ~19-22 nucleotides in length, the altered miRNA pattern being connected to pathological status. miRNAs are highly stable transcripts, and these can be assessed from formalin-fixed paraffin-embedded (FFPE) samples leading to the identification of miRNAs that could be developed as diagnostic and prognostic biomarkers, in particular those involved in malignant transformation...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28891864/photosensitization-of-trpa1-and-trpv1-by-7-dehydrocholesterol-implications-for-the-smith-lemli-opitz-syndrome
#9
Alexandru Babes, Cosmin I Ciotu, Tal Hoffmann, Tatjana I Kichko, Tudor Selescu, Cristian Neacsu, Susanne K Sauer, Peter W Reeh, Michael J M Fischer
Loss of function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the large majority of Smith-Lemli-Opitz syndrome patients. In order to identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28890735/fluid-driven-metamorphism-of-the-continental-crust-governed-by-nanoscale-fluid-flow
#10
Oliver Plümper, Alexandru Botan, Catharina Los, Yang Liu, Anders Malthe-Sørenssen, Bjørn Jamtveit
The transport of fluids through the Earth's crust controls the redistribution of elements to form mineral and hydrocarbon deposits, the release and sequestration of greenhouse gases, and facilitates metamorphic reactions that influence lithospheric rheology. In permeable systems with a well-connected porosity, fluid transport is largely driven by fluid pressure gradients. In less permeable rocks, deformation may induce permeability by creating interconnected heterogeneities, but without these perturbations, mass transport is limited along grain boundaries or relies on transformation processes that self-generate transient fluid pathways...
September 2017: Nature Geoscience
https://www.readbyqxmd.com/read/28887086/the-effects-of-cinnamon-supplementation-on-blood-lipid-concentrations-a-systematic-review-and-meta-analysis
#11
Serban M Maierean, Maria-Corina Serban, Amirhossein Sahebkar, Sorin Ursoniu, Alexandru Serban, Peter Penson, Maciej Banach
BACKGROUND: Cinnamon is a rich botanical source of polyphenols, whose positive effects on blood lipid concentrations have been hypothesized, but have not been conclusively studied. OBJECTIVE: The objective of the study was to systematically review and evaluate the effect of administration of cinnamon on blood lipid concentrations. METHODS: We assessed 13 randomized controlled trials with 750 participants investigating the effect of cinnamon supplementation on blood lipid concentrations...
August 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28882972/ileocecal-obstruction-due-to-endometriosis-a-case-report-and-literature-review
#12
Nicolae Bacalbasa, Irina Balescu, Alexandru Filipescu
Endometriosis is a common finding in premenopausal women and a significant number of cases presenting digestive tract involvement at the time of diagnosis. However, most of these patients present pelvic nodules involving the rectosigmoidian junction, other digestive tract segments being less commonly affected. We present the case of a 37-year-old nulliparous woman who presented for diffuse abdominal pain and vomiting; she was diagnosed with complete ileocecal obstruction due to an endometriosis nodule in association with bilateral ovarian endometriosis lesions invading the rectosigmodian wall...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882077/review-the-potential-impact-of-surface-crystalline-states-of-titanium-for-biomedical-applications
#13
Julien Barthes, Sait Ciftci, Florian Ponzio, Helena Knopf-Marques, Liza Pelyhe, Alexandru Gudima, Imre Kientzl, Eszter Bognár, Miklós Weszl, Julia Kzhyshkowska, Nihal Engin Vrana
In many biomedical applications, titanium forms an interface with tissues, which is crucial to ensure its long-term stability and safety. In order to exert control over this process, titanium implants have been treated with various methods that induce physicochemical changes at nano and microscales. In the past 20 years, most of the studies have been conducted to see the effect of topographical and physicochemical changes of titanium surface after surface treatments on cells behavior and bacteria adhesion...
September 7, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28879701/mirnas-expressions-and-interaction-with-biological-systems-in-patients-with-alzheimer-s-disease-using-mirnas-as-a-diagnosis-and-prognosis-biomarker
#14
REVIEW
Silvius I Negoita, Dorel Sandesc, Alexandru F Rogobete, Madalina Dutu, Ovidiu H Bedreag, Marius Papurica, Muhammed F Ercisli, Sonia E Popovici, Raluca Dumache, Mihai Sandesc, Anca Dinu, Adriana M Sas, Denis Serban, Dan Corneci
BACKGROUND: A high percentage of patients develop Alzheimer`s disease (AD). The main signs are loss of memory and cognitive functions which have a significant impact on lifestyle. Numerous studies have been conducted to identify new biomarkers for early diagnosis of patients with AD. An ideal biomarker is represented by the expression of miRNAs. In this paper, we want to summarize expressions miRNAs in AD. We also want to present the pathophysiological and genetic interactions of miRNAs with protein systems in these patients...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879646/acromegaly-treatment-in-romania-how-close-are-we-to-disease-control
#15
Dan Alexandru Niculescu, Ionela Florina Baciu, Cristina Capatina, Simona Andreea Galoiu, Monica Livia Gheorghiu, Serban Radian, Raluca Alexandra Trifanescu, Andra Caragheorgheopol, Mihail Coculescu, Catalina Poiana
INTRODUCTION: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly. MATERIAL AND METHODS: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28877576/unusual-location-of-hydatid-cysts-report-of-two-cases-in-the-heart-and-hip-joint-of-romanian-patients
#16
Simona Gurzu, Marius Alexandru Beleaua, Emeric Egyed-Zsigmond, Ioan Jung
Hydatid cyst is usually located in the liver and lungs, rare cases showing localization in other organs or tissues. In the unusual location, echinococcosis is an excluding diagnosis that is established only after microscopic evaluation. Our first case occurred in a 67-year-old female previously diagnosed with pulmonary tuberculosis and hospitalized with persistent pain in the hip joint. The clinical diagnosis was tuberculosis of the joint, but the presence of the specific acellular membrane indicated a hydatid cyst of the synovial membrane, without bone involvement...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28876056/paramagnetism-in-metallacarboranes-the-polyhedral-chromadicarbaborane-systems
#17
Szabolcs Jákó, Alexandru Lupan, Attila-Zsolt Kun, R Bruce King
The chromadicarbaboranes CpCrC2Bn-3Hn-1 (8 ≤ n ≤ 12) are of interest in providing stable paramagnetic deltahedral metallaboranes among which the 12-vertex CpCrC2B9H11 has been synthesized by Hawthorne and co-workers. Density functional theory shows that the lowest-energy such structures are quartet spin-state Cr(III) structures in which the central CrC2Bn-3 units exhibit most spherical closo deltahedral geometries similar to those found in the borane dianions BnHn(2-). Higher-energy doublet CpCrC2Bn-3Hn-1 (8 ≤ n ≤ 11) structures are found exhibiting central CrC2Bn-3 isocloso deltahedral geometries, thereby providing a degree 6 vertex for the chromium atom...
September 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28874706/synthesis-of-arbitrary-quantum-circuits-to-topological-assembly-systematic-online-and-compact
#18
Alexandru Paler, Austin G Fowler, Robert Wille
It is challenging to transform an arbitrary quantum circuit into a form protected by surface code quantum error correcting codes (a variant of topological quantum error correction), especially if the goal is to minimise overhead. One of the issues is the efficient placement of magic state distillation sub circuits, so-called distillation boxes, in the space-time volume that abstracts the computation's required resources. This work presents a general, systematic, online method for the synthesis of such circuits...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868073/antithrombotic-treatment-tailoring-and-risk-score-evaluation-in-elderly-patients-diagnosed-with-an-acute-coronary-syndrome
#19
REVIEW
Alexandru Nicolae Mischie, Catalina Liliana Andrei, Crina Sinescu, Gani Bajraktari, Eugen Ivan, Georgios Nikolaos Chatziathanasiou, Michele Schiariti
Age is an important prognostic factor in the outcome of acute coronary syndromes (ACS). A substantial percentage of patients who experience ACS is more than 75 years old, and they represent the fastest-growing segment of the population treated in this setting. These patients present different patterns of responses to pharmacotherapy, namely, a higher ischemic and bleeding risk than do patients under 75 years of age. Our aim was to identify whether the currently available ACS ischemic and bleeding risk scores, which has been validated for the general population, may also apply to the elderly population...
July 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28866542/skeleton-based-scagnostics
#20
Jose Matute, Alexandru C Telea, Lars Linsen
Scatterplot matrices (SPLOMs) are widely used for exploring multidimensional data. Scatterplot diagnostics (scagnostics) approaches measure characteristics of scatterplots to automatically find potentially interesting plots, thereby making SPLOMs more scalable with the dimension count. While statistical measures such as regression lines can capture orientation, and graph-theoretic scagnostics measures can capture shape, there is no scatterplot characterization measure that uses both descriptors. Based on well-known results in shape analysis, we propose a scagnostics approach that captures both scatterplot shape and orientation using skeletons (or medial axes)...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
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