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https://www.readbyqxmd.com/read/28213234/dna-wrapped-multi-walled-carbon-nanotube-modified-electrochemical-biosensor-for-the-detection-of-escherichia-coli-from-real-samples
#1
Dilsat Ozkan-Ariksoysal, Yasin Ugur Kayran, Fethiye Ferda Yilmaz, Anton Alexandru Ciucu, Iulia Gabriela David, Vasile David, Mine Hosgor-Limoncu, Mehmet Ozsoz
This paper introduces DNA-wrapped multi-walled carbon nanotube (MWCNT)-modified genosensor for the detection of Escherichia coli (E. coli) from polymerase chain reaction (PCR)-amplified real samples while Staphylococcus aureus (S. aureus) was used to investigate the selectivity of the biosensor. The capture probe specifically recognizing E. coli DNA and it was firstly interacted with MWCNTs for wrapping of single-stranded DNA (ssDNA) onto the nanomaterial. DNA-wrapped MWCNTs were then immobilised on the surface of disposable pencil graphite electrode (PGE) for the detection of DNA hybridization...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212196/prison-nursing-formation-of-a-stable-professional-identity
#2
Khurshid Choudhry, David Armstrong, Alexandru Dregan
AIM: The aim of this study was to analyze how working within prison environments can influence the self-identity and professional identity of nurses. BACKGROUND: The prison environment can be a difficult environment for nurses to deliver care within, with nurses having to carry out activities that seem to go against their professional role, while at the same time providing care to prisoners who have greater health needs than the general population. There is a lack of theoretical consideration of how prison nurses carry out their role in the face of such challenges...
January 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28196204/selective-extraocular-muscle-atrophy-secondary-to-chronic-oculomotor-denervation
#3
Andrei-Alexandru Szigiato, Donald H Lee, J Alexander Fraser
No abstract text is available yet for this article.
February 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28194457/disposable-cartridge-platform-for-rapid-detection-of-viral-hemorrhagic-fever-viruses
#4
Steven M Scherr, David S Freedman, Krystle N Agans, Alexandru Rosca, Erik Carter, Melody Kuroda, Helen E Fawcett, Chad E Mire, Thomas W Geisbert, M Selim Ünlü, John H Connor
Light microscopy is a straightforward and highly portable imaging approach that is used for the detection of parasites, fungi, and bacteria. The detection of individual virus particles has historically not been possible through this approach. Thus, characterization of virus particles is typically performed using high-energy approaches such as electron microscopy. These approaches require purification of virions away from its normal milieu, significant levels of expertise, and only count a small number of particles at a time...
February 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28192485/correction-grey-matter-microstructural-integrity-alterations-in-blepharospasm-are-partially-reversed-by-botulinum-neurotoxin-therapy
#5
Alexandru Hanganu, Muthuraman Muthuraman, Venkata Chaitanya Chirumamilla, Nabin Koirala, Burcu Paktas, Günther Deuschl, Kirsten E Zeuner, Sergiu Groppa
[This corrects the article DOI: 10.1371/journal.pone.0168652.].
2017: PloS One
https://www.readbyqxmd.com/read/28186787/strange-quark-magnetic-moment-of-the-nucleon-at-the-physical-point
#6
Raza Sabbir Sufian, Yi-Bo Yang, Andrei Alexandru, Terrence Draper, Jian Liang, Keh-Fei Liu
We report a lattice QCD calculation of the strange quark contribution to the nucleon's magnetic moment and charge radius. This analysis presents the first direct determination of strange electromagnetic form factors including at the physical pion mass. We perform a model-independent extraction of the strange magnetic moment and the strange charge radius from the electromagnetic form factors in the momentum transfer range of 0.051  GeV^{2}≲Q^{2}≲1.31  GeV^{2}. The finite lattice spacing and finite volume corrections are included in a global fit with 24 valence quark masses on four lattices with different lattice spacings, different volumes, and four sea quark masses including one at the physical pion mass...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28186505/n-glycosylation-of-mouse-trail-r-and-human-trail-r1-enhances-trail-induced-death
#7
Florent Dufour, Thibault Rattier, Sarah Shirley, Gaelle Picarda, Andrei Alexandru Constantinescu, Aymeric Morlé, Al Batoul Zakaria, Guillaume Marcion, Sebastien Causse, Eva Szegezdi, Dirk Michael Zajonc, Renaud Seigneuric, Gilles Guichard, Tijani Gharbi, Fabien Picaud, Guillaume Herlem, Carmen Garrido, Pascal Schneider, Chris Alan Benedict, Olivier Micheau
APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important regulatory role for TRAIL-R1-mediated and mouse TRAIL receptor (mTRAIL-R)-mediated apoptosis, but not for TRAIL-R2, which is devoid of N-glycans. Cells expressing N-glyc-defective mutants of TRAIL-R1 and mouse TRAIL-R were less sensitive to TRAIL than their wild-type counterparts. Defective apoptotic signaling by N-glyc-deficient TRAIL receptors was associated with lower TRAIL receptor aggregation and reduced DISC formation, but not with reduced TRAIL-binding affinity...
February 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28182153/switching-bipolar-disorder-patients-treated-with-clozapine-to-another-antipsychotic-medication-a-mirror-image-study
#8
Petru Ifteni, Andreea Teodorescu, Marius Alexandru Moga, Alina Mihaela Pascu, Roxana Steliana Miclaus
Bipolar disorder (BD) is associated with periodic symptom exacerbations, leading to functional impairment, and increased risk of suicide. Although clozapine has never been approved for the treatment of BD, it is occasionally used in severe mania. The aim of the study is to evaluate the risks and benefits of switching clozapine in remitted BD patients. This is an observational, mirror image study of 62 consecutive remitted BD outpatients treated with clozapine. Twenty-five patients were switched to another antipsychotic following a change in a drug reimbursement rule, while 37 continued on clozapine...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28181238/tree-species-diversity-affects-decomposition-through-modified-micro-environmental-conditions-across-european-forests
#9
François-Xavier Joly, Alexandru Milcu, Michael Scherer-Lorenzen, Loreline-Katia Jean, Filippo Bussotti, Seid Muhie Dawud, Sandra Müller, Martina Pollastrini, Karsten Raulund-Rasmussen, Lars Vesterdal, Stephan Hättenschwiler
Different tree species influence litter decomposition directly through species-specific litter traits, and indirectly through distinct modifications of the local decomposition environment. Whether these indirect effects on decomposition are influenced by tree species diversity is presently not clear. We addressed this question by studying the decomposition of two common substrates, cellulose paper and wood sticks, in a total of 209 forest stands of varying tree species diversity across six major forest types at the scale of Europe...
February 9, 2017: New Phytologist
https://www.readbyqxmd.com/read/28177230/synthesis-crystal-structures-and-magnetic-properties-of-two-novel-cyanido-bridged-heterotrimetallic-cu-ii-mn-ii-cr-iii-complexes
#10
Maria-Gabriela Alexandru, Diana Visinescu, Sergiu Shova, Marius Andruh, Francesc Lloret, Miguel Julve
The self-assembly process between the heteroleptic [Cr(III)(phen)(CN)4](-) and [Cr(III)(ampy)(CN)4](-) metalloligands and the heterobimetallic {Cu(II)(valpn)Mn(II)}(2+) tecton afforded two heterotrimetallic complexes of formula [{Cu(II)(valpn)Mn(II)(μ-NC)2Cr(III)(phen)(CN)2}2{(μ-NC)Cr(III)(phen)(CN)3}2]·2CH3CN (1) and {[Cu(II)(valpn)Mn(II)(μ-NC)2Cr(III)(ampy)(CN)2]2·2CH3CN}n (2) [phen = 1,10-phenanthroline, ampy = 2-aminomethylpyridine, and H2valpn = 1,3-propanedyilbis(2-iminomethylene-6-methoxyphenol)]...
February 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28164622/using-the-expression-of-mirnas-as-biomarkers-for-the-evaluation-acute-respiratory-distress-syndrome-in-the-critically-ill-polytrauma-patient
#11
REVIEW
Marius Papurica, Alexandru F Rogobete, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Lavinia M Bratu, Sonia E Popovici, Dorel Sandesc, Corina Vernic, Ovidiu H Bedreag
BACKGROUND: A high percentage of critically ill polytrauma patients develop acute respiratory distress syndrome (ARDS), both because of the primary traumatic injuries and because of the secondary post-traumatic injuries. For adequate management of these patients, new complex evaluation and monitoring methods are needed, methods that could answer as many questions as possible regarding the pathophysiological changes associated with ARDS. Currently, a series of clinical and biochemical markers are being used which unfortunately do not respond to the needs of an intensive care clinician...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164614/using-circulating-mirnas-as-biomarkers-for-the-evaluation-and-monitoring-of-the-mitochondrial-damage-in-the-critically-ill-polytrauma-patients
#12
REVIEW
Ovidiu H Bedreag, Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Raluca Dumache, Carmen A Cradigati, Mirela Sarandan, Lavinia M Bratu, Sonia E Popovici, Laurentiu V Sima
BACKGROUND: The multiple-traumatic critical patient presents a variety of pathophysiological, cellular, and molecular dysfunctions. One of the most important is represented by mitochondrial damage which afterwards is responsible for the augmentation and worsening of a series of pathologies that lead to the worsening of the clinical status of the patient. The severe inflammatory response, sepsis, and the redox imbalance are other pathologies that together with the multiple traumas are responsible for the mitochondrial dysfunctions...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164596/genetic-expression-in-cystic-fibrosis-related-bone-disease-an-observational-transversal-cross-sectional-study
#13
Ioana M Ciuca, Liviu L Pop, Alexandru F Rogobete, Dan I Onet, Bogdan Guta-Almajan, Zoran Popa, Florin G Horhat
BACKGROUND: Cystic fibrosis (CF) is the most frequent monogenic genetic disease with autosomal recessive transmission and characterized by important clinical polymorphism and significant lethal prospective. CF related bone disease occurs frequently in adults with CF. Childhood is the period of bone formation, and therefore, children are more susceptible to low bone density. Several factors like pancreatic insufficiency, hormone imbalance, and physical inactivity contribute to CF bone disease development...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164593/modulation-of-the-redox-expression-and-inflammation-response-in-the-critically-ill-polytrauma-patient-with-thoracic-injury-statistical-correlations-between-antioxidant-therapy
#14
Ovidiu H Bedreag, Alexandru F Rogobete, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Sonia E Popovici, Raluca Dumache, Florin G Horhat, Corina Vernic, Laurentiu V Sima, Loredana Luca, Marius Papurica
BACKGROUND: One of the major causes of mortality in the world is represented by multiple traumas. Thoracic trauma is commonly associated with polytraumas. A series of physiopathological complications follow polytraumas, leading to a significant decrease in the survival rate. As a result of injuries, significant quantities of free radicals (FR) are produced, responsible for oxidative stress (OS). To minimize the effects of OS, we recommend the administration of antioxidant substances. In this study we want to highlight statistically significant correlations between antioxidant therapy and a series of clinical variables...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164582/the-use-of-lipid-peroxidation-expression-as-a-biomarker-for-the-molecular-damage-in-the-critically-ill-polytrauma-patient
#15
REVIEW
Florin G Horhat, Alexandru F Rogobete, Marius Papurica, Dorel Sandesc, Sonia Tanasescu, Victor Dumitrascu, Monica Licker, Razvan Nitu, Carmen A Cradigati, Mirela Sarandan, Ovidiu Boruga, Ciprian D Crisan, Emil Ungureanu, Daniela M Popa, Sonia E Popovici, Ovidiu H Bedreag
BACKGROUND: The critically ill polytrauma patient, apart from the primary, traumatic injuries and the secondary, port-traumatic injuries, presents with a series of molecular disasters. Dysfunctions of the biochemical pathways and molecular damage add to the worsening of the clinical status of these patients, one of the most well-known molecular phenomena being oxidative stress (OS), responsible for an escalation of the inflammatory status, multiple infections, and multiple organ dysfunction syndrome (MODS)...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164539/post-mortem-identification-of-a-fire-carbonized-body-by-str-genotyping
#16
Raluca Dumache, Camelia Muresan, Veronica Ciocan, Alexandru F Rogobete, Alexandra Enache
BACKGROUND: Identification of bodies of unknown identity that are victims of exposure to very high temperatures, resulting from fires, plane crashes, and terrorist attacks, represents one of the most difficult sides of forensic genetics, because of the advanced state of decomposition. The aim of this study was the identification of the carbonized cadaver of a fire victim through STR genotyping. METHODS: We used blood samples obtained from the iliac artery during the autopsy examination as biological samples from the unidentified victim...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164531/literature-research-regarding-mirnas-expression-in-the-assessment-and-evaluation-of-the-critically-ill-polytrauma-patient-with-traumatic-brain-and-spinal-cord-injury
#17
Lavinia M Bratu, Alexandru F Rogobete, Marius Papurica, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Sonia E Popovici, Dan C Crisan, Horia Stanca, Sonia Tanasescu, Ovidiu H Bedreag
BACKGROUND: One of the most severe conditions specific to the critically ill polytrauma patient is traumatic brain injury and traumatic spinal cord injury. The mortality rate is high in the case of these patients, both because of the direct traumatic lesions, and because of the pathophysiological imbalances associated with trauma. Amongst the most common pathologies associated with the critically ill polytrauma patients responsible for a lower survival rate, are redox imbalance, systemic inflammatory response, infections, and multiple organ dysfunction syndrome...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164521/using-the-expression-of-damage-associated-molecular-pattern-damp-for-the-evaluation-and-monitoring-of-the-critically-ill-polytrauma-patient
#18
REVIEW
Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Florin G Horhat, Lavinia M Bratu, Razvan Nitu, Dan C Crisan, Delia I Horhat, Elena S Popovici, Sonia Tanasescu, Vlad Daliborca, Ovidiu Boruga, Ovidiu H Bedreag
BACKGROUND: The critically ill polytrauma patient continues to be one of the most complex cases in the intensive care unit (ICU). The molecular damage is closely connected with the severe, specific pathophysiological imbalances, such as severe inflammation, infections, hypermetabolism, oxidative stress, and ultimately multiple organ dysfunction syndrome (MODS). METHODS: The literature available on PubMed and Scopus was analysed for this study. The key words used in the search were "biomarkers in critically ill patients", "molecular damage", "sepsis biomarkers", "miRNAs biomarkers", and "oxidative stress"...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159717/generation-of-anti-inflammatory-macrophages-for-implants-and-regenerative-medicine-using-self-standing-release-systems-with-a-phenotype-fixing-cytokine-cocktail-formulation
#19
Vladimir Riabov, Fabián Salazar, Su Su Htwe, Alexandru Gudima, Christina Schmuttermaier, Julien Barthes, Helena Knopf-Marques, Harald Klüter, Amir M Ghaemmaghami, Nihal Engin Vrana, Julia Kzhyshkowska
: The immediate tissue microenvironment of implanted biomedical devices and engineered tissues is highly influential on their long term fate and efficacy. The creation of a long-term anti-inflammatory microenvironment around implants and artificial tissues can facilitate their integration. Macrophages are highly plastic cells that define the tissue reactions on the implanted material. Local control of macrophage phenotype by long-term fixation of their healing activities and suppression of inflammatory reactions are required to improve implant acceptance...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28153611/phosphoglycerol-dihydroceramide-a-distinctive-ceramide-produced-by-porphyromonas-gingivalis-promotes-rankl-induced-osteoclastogenesis-by-acting-on-non-muscle-myosin-ii-a-myh9-an-osteoclast-cell-fusion-regulatory-factor
#20
Hiroyuki Kanzaki, Alexandru Movila, Rayyan Kayal, Marcelo H Napimoga, Kenji Egashira, Floyd Dewhirst, Hajime Sasaki, Mohammed Howait, Ayman Al-Dharrab, Abdulghani Mira, Xiaozhe Han, Martin A Taubman, Frank C Nichols, Toshihisa Kawai
Among several virulence factors produced by the periodontal pathogen Porphyromonas gingivalis (Pg), a recently identified novel class of dihydroceramide lipids that contains a long acyl-chain has the potential to play a pathogenic role in periodontitis because of its higher level of tissue penetration compared to other lipid classes produced by Pg. However, the possible impact of Pg ceramides on osteoclastogenesis is largely unknown. In the present study, we report that the phosphoglycerol dihydroceramide (PGDHC) isolated from Pg enhanced osteoclastogenesis in vitro and in vivo...
January 31, 2017: Biochimica et Biophysica Acta
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