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Alexandru I Tomescu, Paul Medvedev
Contig assembly is the first stage that most assemblers solve when reconstructing a genome from a set of reads. Its output consists of contigs-a set of strings that are promised to appear in any genome that could have generated the reads. From the introduction of contigs 20 years ago, assemblers have tried to obtain longer and longer contigs, but the following question remains: given a genome graph G (e.g., a de Bruijn, or a string graph), what are all the strings that can be safely reported from G as contigs? In this article, we answer this question using a model in which the genome is a circular covering walk...
October 17, 2016: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
Jeremiah Wasserlauf, Bradley P Knight, Zhi Li, Adin-Cristian Andrei, Rishi Arora, Alexandru B Chicos, Jeffrey J Goldberger, Susan S Kim, Albert C Lin, Nishant Verma, Martha M Bohn, Rod S Passman
BACKGROUND: Cryoballoon ablation (CBA) for paroxysmal atrial fibrillation (pAF) can be performed under general anesthesia (GA) or moderate sedation (MS). Our objective was to compare the effectiveness, safety, procedure duration, and time spent in the electrophysiology (EP) laboratory for CBA performed under GA and MS. METHODS: . Patients undergoing a first CBA for pAF were identified. Patients received either GA administered by an anesthesiologist or MS with midazolam and fentanyl administered by EP laboratory staff...
October 17, 2016: Pacing and Clinical Electrophysiology: PACE
Anca Trifan, Oana Stoica, Catalin-Alexandru Chihaia, Mihai Danciu, Carol Stanciu, Ana-Maria Singeap
INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by a marked eosinophilic infiltrate in the esophageal mucosa. What was once considered a rare disease has nowadays become one of the most frequent esophageal diseases in the Western countries, occupying a place just next to the gastroesophageal reflux disease. EoE etiology and pathogenesis remain largely unknown, although most studies consider that allergic and genetic factors play the most important role...
October 2016: Medicine (Baltimore)
Liviu Cristian Tănase, Nicoleta Georgiana Apostol, Laura Elena Abramiuc, Cristian Alexandru Tache, Luminița Hrib, Lucian Trupină, Lucian Pintilie, Cristian Mihail Teodorescu
Atomically clean lead zirco-titanate PbZr0.2Ti0.8O3 (001) layers exhibit a polarization oriented inwards P((-)), visible by a band bending of all core levels towards lower binding energies, whereas as introduced layers exhibit P((+)) polarization under air or in ultrahigh vacuum. The magnitude of the inwards polarization decreases when the temperature is increased at 700 K. CO adsorption on P((-)) polarized surfaces saturates at about one quarter of a monolayer of carbon, and occurs in both molecular (oxidized) and dissociated (reduced) states of carbon, with a large majority of reduced state...
October 14, 2016: Scientific Reports
Agnes Mayr, Daniel Kitterer, Joerg Latus, Hannah Steubing, Joerg Henes, Francesco Vecchio, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt, Simon Greulich
BACKGROUND: Severe arrhythmias or heart failure may be surrogates of myocardial involvement in patients with connective tissue disorders (CTD). However, most patients present with unspecific symptoms, normal ECG, and preserved left ventricular ejection fraction (LV-EF). Therefore, timely diagnosis by an accurate technique is crucial. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has proven value for the detection of focal processes, but due to the often diffuse character of fibrosis/inflammation in CTD patients, CMR mapping techniques might be of incremental value for the assessment of myocardial involvement...
October 13, 2016: Journal of Cardiovascular Magnetic Resonance
Cristina Busuioc, Alexandru Evanghelidis, Andrei Galatanu, Ionut Enculescu
Multiple and complex functionalities are a demand nowadays for almost all materials, including common day-to-day materials such as paper, textiles, wood, etc. In the present report, the surface temperature control of different types of materials, including paper and textiles, was demonstrated by Joule heating of metallic-web transparent electrodes both by direct current and by RF induced eddy currents. Polymeric submicronic fiber webs were prepared by electrospinning, and metal sputtering was subsequently performed to transform them into flexible transparent electrodes...
October 10, 2016: Scientific Reports
Alexandru Movila, Hani Mawardi, Kazuaki Nishimura, Tomomi Kiyama, Kenji Egashira, Jae-Young Kim, Alessandro Villa, Hajime Sasaki, Sook-Bin Woo, Toshihisa Kawai
Prior consensus held that medication-related osteonecrosis of the jaw (MRONJ) lesion was composed of necrotic bone; however, more recent studies have identified inflammatory infiltrates in the lesion. Herein, we report that remarkably elevated infiltrating γδT cells (90% of lymphocytes) express Semaphorin 4D (Sema4D) in human patient with MRONJ lesion, whereas γδT cells only account for 2-5% of lymphocytes in blood. Importantly, Sema4D is implicated in the pathogenesis of T cell-mediated inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis...
October 5, 2016: Biochemical and Biophysical Research Communications
Didier Frappaz, Alexandre Vasiljevic, Pierre-Aurelien Beuriat, Claire Alapetite, Jacques Grill, Alexandru Szathmari, Cécile Faure-Conter
Ependymomas represent 10% of pediatric brain tumors. In the recent WHO 2016 classification, pathology is enriched by localization and molecular biology. Whatever the age, total removal by one or several looks when required remains a major prognostic factor. In children, focal radiation remains a standard, while the role of chemotherapy is matter of randomized studies. In infants, front line chemotherapy is the standard. Inclusion in the SIOP ependymoma II protocol is encouraged. In case of relapse, further surgery and radiation are advised, while inclusion in innovative trials including re-irradiation, and phase I-II should be encouraged...
October 4, 2016: Bulletin du Cancer
Marcel Ivanov, Alexandru Budu, Hugh Sims-Williams, Ion Poeata
BACKGROUND: Our aim was to evaluate the utility of modern intraoperative ultrasound in the resection of a wide variety of spinal intradural pathological entities. MATERIALS AND METHODS: The authors evaluated patients with spinal cord pathology treated between January 2006 and September 2015. Intraoperative standard B-mode images were acquired using a 3.5-12 MHz US probes (linear and curvilinear) on various ultrasound machines. The benefits and disadvantages of intraoperative ultrasound (iUS) were assessed for each case...
October 3, 2016: World Neurosurgery
B Hu, R Molina, M Döring, A Alexandru
The ρ(770) meson is the most extensively studied resonance in lattice QCD simulations in two (N_{f}=2) and three (N_{f}=2+1) flavor formulations. We analyze N_{f}=2 lattice scattering data using unitarized chiral perturbation theory, allowing not only for the extrapolation in mass but also in flavor, N_{f}=2→N_{f}=2+1. The flavor extrapolation requires information from a global fit to ππ and πK phase shifts from experiment. While the chiral extrapolation of N_{f}=2 lattice data leads to masses of the ρ(770) meson far below the experimental one, we find that the missing KK[over ¯] channel is able to explain this discrepancy...
September 16, 2016: Physical Review Letters
Pompilia Ispas-Szabo, Patrick De Koninck, Carmen Calinescu, Mircea Alexandru Mateescu
Carboxymethyl starch (CMS) is a pH-responsive excipient exhibiting also interesting properties for applications in delayed drug delivery systems. This work was aimed to investigate the release properties of monolithic and dry-coated tablets based on ionic sodium CMS and on protonated CMS, formulated with three model tracers: acetaminophen, acetylsalicylic acid (ASA), and sodium diclofenac. The sodium or protonated CMS were obtained from the same CMS synthesis by controlling the final pH of reaction media. The two forms of CMS were confirmed by the Fourier transform infrared spectroscopy...
September 29, 2016: AAPS PharmSciTech
Catalin Vlad, Paul Kubelac, Andrea Onisim, Bogdan Fetica, Annamaria Fulop, Alexandru Irimie, Patriciu Achimas-Cadariu
PURPOSE: The tumor microenvironment in ovarian cancer (OC) seems to play an important role, and besides tumor cells, biomarkers can derive from endothelial cells. We investigated CDCP1 and ADAM12 expression in relation with other clinical and pathological characteristics in OC patients. METHODS: We retrospectively evaluated patient files between 2006-2011. A histochemical score was developed to evaluate tumor staining, the microvessel density (MVD), and stromal expression patterns for both ADAM12 and CDCP1...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Juyoen Hur, Alexandru D Iordan, Florin Dolcos, Howard Berenbaum
Although there has been steady progress elucidating the influence of emotion on cognition, it remains unclear precisely when and why emotion impairs or facilitates cognition. The present study investigated the mechanisms involved in the influence of emotion on perception and working memory (WM), using modified 0-back and 2-back tasks, respectively. First, results showed that attentional focus modulated the impact of emotion on perception. Specifically, emotion facilitated perceptual task performance when it was relevant to the task, but it impaired performance when it was irrelevant to the task...
August 16, 2016: Cognition & Emotion
Carmen Fierbinteanu-Braticevici, Crina Sinescu, Alexandru Moldoveanu, Ana Petrisor, Sorina Diaconu, Dragos Cretoiu, Bogdan Braticevici
Nonalcoholic fatty liver disease (NAFLD) is very prevalent and now considered the most common cause of chronic liver disease. Staging the severity of liver damage is very important because the prognosis of NAFLD is highly variable. The long-term prognosis of patients with NAFLD remains incompletely elucidated. Even though the annual fibrosis progression rate is significantly higher in patients with nonalcoholic hepatitis (NASH), both types of NAFLD (nonalcoholic fatty liver and nonalcoholic steatohepatitis) can lead to fibrosis...
September 28, 2016: Cell Biology and Toxicology
Alexandru Oanţă, Marius Irimie
In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19)...
August 2016: Acta Dermatovenerologica Croatica: ADC
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas, Stefan Agewall, John Camm, Gonzalo Baron Esquivias, Werner Budts, Scipione Carerj, Filip Casselman, Antonio Coca, Raffaele De Caterina, Spiridon Deftereos, Dobromir Dobrev, José M Ferro, Gerasimos Filippatos, Donna Fitzsimons, Bulent Gorenek, Maxine Guenoun, Stefan H Hohnloser, Philippe Kolh, Gregory Y H Lip, Athanasios Manolis, John McMurray, Piotr Ponikowski, Raphael Rosenhek, Frank Ruschitzka, Irina Savelieva, Sanjay Sharma, Piotr Suwalski, Juan Luis Tamargo, Clare J Taylor, Isabelle C Van Gelder, Adriaan A Voors, Stephan Windecker, Jose Luis Zamorano, Katja Zeppenfeld
No abstract text is available yet for this article.
September 23, 2016: European Journal of Cardio-thoracic Surgery
Cristiana David, Ileana Peride, Andrei Niculae, Alexandra Maria Constantin, Ionel Alexandru Checherita
BACKGROUND: Native arteriovenous fistula (AVF) is the most appropriate type of vascular access for chronic dialysis. Its patency rates depend on vascular wall characteristics. Ketoacid analogues of essential amino acids (KA/EAA) are prescribed in end-stage renal disease (ESRD) pre-dialysis patients to lower toxic metabolic products generation and improve nutritional status. We hypothesized that very-low protein diet (VLPD) supplemented with KA/EAA may influence arterial wall stiffness and affect AVF maturation rates and duration in pre-dialysis ESRD patients...
September 20, 2016: BMC Nephrology
Julio Gallego-Delgado, Upal Basu-Roy, Maureen Ty, Matilde Alique, Cristina Fernandez-Arias, Alexandru Movila, Pollyanna Gomes, Ada Weinstock, Wenyue Xu, Innocent Edagha, Samuel C Wassmer, Thomas Walther, Marta Ruiz-Ortega, Ana Rodriguez
Cerebral malaria is characterized by cytoadhesion of Plasmodium falciparum-infected red blood cells (Pf-iRBCs) to endothelial cells in the brain, disruption of the blood-brain barrier, and cerebral microhemorrhages. No available antimalarial drugs specifically target the endothelial disruptions underlying this complication, which is responsible for the majority of malaria-associated deaths. Here, we have demonstrated that ruptured Pf-iRBCs induce activation of β-catenin, leading to disruption of inter-endothelial cell junctions in human brain microvascular endothelial cells (HBMECs)...
October 3, 2016: Journal of Clinical Investigation
Magdalena Kozerska, Janusz Skrzat, Alexandru Spulber, Jerzy Walocha, Sebastian Wroński, Jacek Tarasiuk
PURPOSE: To depict the anatomy of the tympanic segment of the facial canal using a 3D visualization technique, to detect dehiscences, and to evaluate their frequency, location, shape, and size. METHODS: Research included 36 human temporal bones (18 infant and 18 adult samples) which were scanned using a Nanotom 180N device. The final resolution of the reconstructed object was 18 µm. Obtained micro-CT data were subsequently processed by the volume rendering software...
September 16, 2016: Surgical and Radiologic Anatomy: SRA
Julia Grapsa, Vijay Kunadian, Davide Capodanno, Rafael Vidal-Perez, Maria Radu, Panagiota Christia, Anastasia Efimova, Stephan Windecker, Patrizio Lancellotti, Bernard Cosyns, Erwan Donal, Bogdan Alexandru Popescu, Gilbert Habib
No abstract text is available yet for this article.
September 13, 2016: European Heart Journal Cardiovascular Imaging
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