keyword
MENU ▼
Read by QxMD icon Read
search

alexandru

keyword
https://www.readbyqxmd.com/read/28817681/pressure-in-isochoric-systems-containing-aqueous-solutions-at-subzero-centigrade-temperatures
#1
Gideon Ukpai, Gabriel Năstase, Alexandru Șerban, Boris Rubinsky
OBJECTIVE: Preservation of biological materials at subzero Centigrade temperatures, cryopreservation, is important for the field of tissue engineering and organ transplantation. Our group is studying the use of isochoric (constant volume) systems of aqueous solution for cryopreservation. Previous studies measured the pressure-temperature relations in aqueous isochoric systems in the temperature range from 0°C to - 20°C. The goal of this study is to expand the pressure-temperature measurement beyond the range reported in previous publications...
2017: PloS One
https://www.readbyqxmd.com/read/28816020/real-world-efficacy-and-safety-of-ombitasvir-paritaprevir-r-dasabuvir-ribavirin-in-genotype-1b-patients-with-hcv-liver-cirrhosis
#2
Carmen Monica Preda, Corneliu Petru Popescu, Cristian Baicus, Theodor Voiosu, Mircea Manuc, Corina Silvia Pop, Liana Gheorghe, Ioan Sporea, Anca Trifan, Marcel Tantau, Alina Tantau, Emanoil Ceausu, Doina Proca, Ileana Constantinescu, Simona Maria Ruta, Mircea Diculescu, Alexandru Oproiu
BACKGROUND: Direct antiviral agents (DAA) showed very good results in terms of efficacy and safety in clinical trials, but real life data are still needed in order to confirm this profile. MATERIAL AND METHODS: In Romania, through a nationwide government-funded programme in 2015-2016, approx.5800 patients with virus C liver cirrhosis received fully reimbursed DAA therapy with OBV/PTV/r+DSV+RBV for 12 weeks. We analysed a national prospective cohort enrolling the first 2070 patients, all with genotype 1b...
August 17, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28814757/top-canopy-nitrogen-allocation-linked-to-increased-grassland-carbon-uptake-in-stands-of-varying-species-richness
#3
Alexandru Milcu, Arthur Gessler, Christiane Roscher, Laura Rose, Zachary Kayler, Dörte Bachmann, Karin Pirhofer-Walzl, Saša Zavadlav, Lucia Galiano, Tina Buchmann, Michael Scherer-Lorenzen, Jacques Roy
Models predict that vertical gradients of foliar nitrogen (N) allocation, increasing from bottom to top of plant canopies, emerge as a plastic response to optimise N utilisation for carbon assimilation. While this mechanism has been well documented in monocultures, its relevance for mixed stands of varying species richness remains poorly understood. We used 21 naturally assembled grassland communities to analyse the gradients of N in the canopy using N allocation coefficients (K N ) estimated from the distribution of N per foliar surface area (KN-F) and ground surface area (KN-G)...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#4
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28808839/individuals-with-autism-have-higher-8-iso-pgf2%C3%AE-levels-than-controls-but-no-correlation-with-quantitative-assay-of-paraoxonase-1-serum-levels
#5
Bianca Pop, Alexandru-Ștefan Niculae, Tudor Lucian Pop, Andreea Liana Răchișan
Autism spectrum disorder (ASD) represents a very large set of neurodevelopmental issues with diverse clinical outcomes. Various hypotheses have been put forth for the etiology of autism spectrum disorder, including issues pertaining to oxidative stress. In this study, we conducted measurements of serum 8-Iso-Prostaglanding F2 α (8-iso-PGF2α, which is the results of non-enzimatically mediated polyunsaturated fatty acid oxidation) in a population of individuals with autism and a control group of age and sex matched controls...
August 14, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28807286/prevalence-and-risk-factors-associated-with-endoparasitic-infection-in-dogs-from-transylvania-romania-a-retrospective-study
#6
Viorica Mircean, Mirabela Oana Dumitrache, Mircea Mircean, Horațiu Alexandru Colosi, Adriana Györke
During six years (April 2010-April 2016) we examined individual feces samples collected from 1314 dogs located in Center and Northwest Romania (Transylvania). Stool samples were analyzed by saturated salt flotation, sedimentation technique and modified Ziehl-Nielsen staining method. The overall prevalence of endoparasitic infections was 66.6% (n=875). Sixteen species/genera of endoparasites were identified. The most prevalent species were Ancylostoma caninum/Uncinaria stenocephala (33.0%) (p=0.0001) followed by Trichocephalus vulpis (25...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806524/assessment-of-effects-of-the-long-term-exposure-of-agricultural-crops-to-carbon-nanotubes
#7
Mohamed Hassen Lahiani, Zeid A Nima, Hector Villagarcia, Alexandru S Biris, Mariya Khodakovskaya
Carbon-based nanomaterials (CBNs) were described as nanomaterials possessing abilities of plant growth regulators. Here, we investigated the effects of long-term exposure of multi-walled carbon nanotubes (MWCNTs) on the growth of three important crops (barley, soybean, corn). The cultivation of all tested species was carried in hydroponics supplemented with 50µg/ml of MWCNTs. After 20 weeks of continuous exposure to the nanomaterials, no significant toxic signs on plant development were observed. Several positive phenotypical changes were recorded in addition to the enhancement of photosynthesis in MWCNTs-exposed crops...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28799361/relaxation-dynamics-of-sierpinski-hexagon-fractal-polymer-exact-analytical-results-in-the-rouse-type-approach-and-numerical-results-in-the-zimm-type-approach
#8
Aurel Jurjiu, Mircea Galiceanu, Alexandru Farcasanu, Liviu Chiriac, Flaviu Turcu
In this paper, we focus on the relaxation dynamics of Sierpinski hexagon fractal polymer. The relaxation dynamics of this fractal polymer is investigated in the framework of the generalized Gaussian structure model using both Rouse and Zimm approaches. In the Rouse-type approach, by performing real-space renormalization transformations, we determine analytically the complete eigenvalue spectrum of the connectivity matrix. Based on the eigenvalues obtained through iterative algebraic relations we calculate the averaged monomer displacement and the mechanical relaxation moduli (storage modulus and loss modulus)...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28797969/bioactive-mesoporous-silica-nanostructures-with-anti-microbial-and-anti-biofilm-properties
#9
Paul Cătălin Balaure, Bianca Boarca, Roxana Cristina Popescu, Diana Savu, Roxana Trusca, Bogdan Ștefan Vasile, Alexandru Mihai Grumezescu, Alina Maria Holban, Alexandra Bolocan, Ecaterina Andronescu
The increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. Nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. Delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. Herein we report the development of SiO2 mesoporous nanosystems loaded with eucalyptus (EUC), orange (ORA), and cinnamon (CIN) essential oils...
August 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28797044/what-can-we-learn-from-sonication-results-of-breast-implants
#10
Frederike M J Reischies, Robert Krause, Judith Holzer, Fabian Tiefenbacher, Raimund Winter, Gertraud Eylert, Tobias Meikl, Alexandru Tuca, Martin J Köfer, Lars P Kamolz, David B Lumenta
BACKGROUND: Different research groups have identified microorganisms on breast implants by sonication with significant correlation to the rate of capsular contracture. This substantiated the hypothesis of an infectious etiology of capsular contracture. However, no clinical consequence has been drawn from these results yet. Aim of this study was to review sonication results from breast implants and to evaluate the current preoperative antibiotic regime for breast-implant surgery. METHODS: We compared breast implant sonication culture results from published reports and our own database...
2017: PloS One
https://www.readbyqxmd.com/read/28783931/low-retinal-dehydrogenase-1-raldh1-level-in-prepubertal-boys-with-autism-spectrum-disorder-a-possible-link-to-dopamine-dysfunction
#11
Denis Pavăl, Florina Rad, Răzvan Rusu, Alexandru-Ştefan Niculae, Horaţiu Alexandru Colosi, Iuliana Dobrescu, Eleonora Dronca
Objective: Retinal dehydrogenase 1 (RALDH1) is a cytosolic enzyme which acts both as a source of retinoic acid (RA) and as a detoxification enzyme. RALDH1 has key functions in the midbrain dopaminergic system, which influences motivation, cognition, and social behavior. Since dopamine has been increasingly linked to autism spectrum disorder (ASD), we asked whether RALDH1 could contribute to the autistic phenotype. Therefore, we investigated for the first time the levels of RALDH1 in autistic patients...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28777640/reversal-of-thermoelectric-current-in-tubular-nanowires
#12
Sigurdur I Erlingsson, Andrei Manolescu, George Alexandru Nemnes, Jens H Bardarson, David Sanchez
We calculate the charge current generated by a temperature bias between the two ends of a tubular nanowire. We show that in the presence of a transversal magnetic field the current can change sign; i.e., electrons can either flow from the hot to the cold reservoir, or in the opposite direction, when the temperature bias increases. This behavior occurs when the magnetic field is sufficiently strong, such that Landau and snaking states are created, and the energy dispersion is nonmonotonic with respect to the longitudinal wave vector...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28776753/assessment-of-the-involvement-of-the-macrophage-migration-inhibitory-factor-glucocorticoid-regulatory-dyad-in-the-expression-of-matrix-metalloproteinase-2-during-periodontitis
#13
Josefine Hirschfeld, Mohammed Howait, Alexandru Movila, Marijo Parčina, Isabelle Bekeredjian-Ding, James Deschner, Søren Jepsen, Toshihisa Kawai
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and counter-regulator of endogenous glucocorticoids (GCs). It is implicated in acute and chronic inflammatory diseases. This study investigated the role of the MIF-GC regulatory dyad in the expression and release of matrix metalloproteinase-2 (MMP-2) during periodontitis, in vivo and in vitro. In a Mif-knockout (KO) mouse model of ligature-induced periodontitis, gingival tissues and blood were collected and analysed for levels of interleukin-6 (IL-6), MIF, MMP-2, and corticosterone...
August 4, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28771989/the-importance-of-the-functional-network-between-endothelial-microparticles-and-late-endothelial-progenitor-cells-for-understanding-the-physiological-aspects-of-this-new-vascular-repair-system
#14
EDITORIAL
Rosita A Condorelli, Aldo E Calogero, Sandro La Vignera
The article by Alexandru and colleagues, entitled "Microparticles of healthy origins improves endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model", represent an important advance in the physiology of the late endothelial progenitor cells (EPCs), documenting the complementary role played by endothelial microparticles (MPs) that play an active role in this repair system. This article is protected by copyright. All rights reserved.
August 3, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28768665/dopamine-reduces-cell-surface-na-h-exchanger-3-nhe3-protein-by-decreasing-nhe3-exocytosis-and-cell-membrane-recycling
#15
Ming Chang Hu, Ion Alexandru Bobulescu, Henry Quiñones, Serge M Gisler, Orson W Moe
The intrarenal autocrine-paracrine dopamine (DA) system mediates a significant fraction of the natriuresis in response to a salt load. DA inhibits a number of Na+ transporters to effect sodium excretion, including the proximal tubule Na+/H+ exchanger-3 (NHE3). DA represent a single hormone that regulates NHE3 at multiple levels including translation, degradation, endocytosis, and protein phosphorylation. Since cell surface NHE3 protein is determined by the balance between exocytotic insertion and endocytotic retrieval, we examined whether DA acutely affects the rate of NHE3 exocytosis in a cell culture model...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28766919/turbulent-kinetic-energy-in-the-right-ventricle-potential-mr-marker-for-risk-stratification-of-adults-with-repaired-tetralogy-of-fallot
#16
Alexandru Fredriksson, Aleksandra Trzebiatowska-Krzynska, Petter Dyverfeldt, Jan Engvall, Tino Ebbers, Carl-Johan Carlhäll
PURPOSE: To assess right ventricular (RV) turbulent kinetic energy (TKE) in patients with repaired Tetralogy of Fallot (rToF) and a spectrum of pulmonary regurgitation (PR), as well as to investigate the relationship between these 4D flow markers and RV remodeling. MATERIALS AND METHODS: Seventeen patients with rToF and 10 healthy controls were included in the study. Patients were divided into two groups based on PR fraction: one lower PR fraction group (≤11%) and one higher PR fraction group (>11%)...
August 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28762950/pasireotide-is-more-effective-than-octreotide-alone-or-combined-with-everolimus-on-human-meningioma-in-vitro
#17
Thomas Graillon, David Romano, Céline Defilles, Christophe Lisbonis, Alexandru Saveanu, Dominique Figarella-Branger, Pierre-Hugues Roche, Stéphane Fuentes, Olivier Chinot, Henry Dufour, Anne Barlier
Pasireotide is a somatostatin analog (SSA) that targets somatostatin receptor subtype 1 (SST1), SST2, SST3, and SST5 with a high affinity. Pasireotide has a better antisecretory effect in acromegaly, Cushing's disease, and neuroendocrine tumors than octreotide. In this study, we compared the effects of pasireotide to those of octreotide in vitro on meningioma primary cell cultures, both alone and in combination with the mTOR inhibitor everolimus. Significant mRNA expression levels of SST1, SST2, and SST5 were observed in 40...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28759306/skeletal-muscle-regeneration-involves-macrophage-myoblast-bonding
#18
Laura Cristina Ceafalan, Tudor Emanuel Fertig, Alexandru Cristian Popescu, Bogdan Ovidiu Popescu, Mihail Eugen Hinescu, Mihaela Gherghiceanu
Regeneration in adult skeletal muscle relies on the activation, proliferation, and fusion of myogenic precursor cells (MPC), mostly resident satellite cells (SC). However, the regulatory mechanism during this process is still under evaluation, with the final aim to manipulate regeneration when the intrinsic mechanism is corrupted. Furthermore, intercellular connections during skeletal muscle regeneration have not been previously thoroughly documented. Our hypothesis was that a direct and close cellular interaction between SC/MPC and invading myeloid cells is a key step in order to control regeneration...
July 31, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28755599/leaf-morphological-variability-and-intraspecific-taxonomic-units-for-pedunculate-oak-and-grayish-oak-genus-quercus-l-series-pedunculatae-schwz-in-southern-carpathian-region-romania
#19
Ecaterina Nicoleta Apostol, Alexandru Lucian Curtu, Liviu Mihai Daia, Bogdan Apostol, Cristiana Georgeta Dinu, Neculae Şofletea
Even though pedunculate oak (Quercus robur L.) and grayish oak (Quercus pedunculiflora K. Koch) have different ecological requirements, they have been considered as having low differentiation at the level of morphological traits and genetic variation. The leaf morphology for 862 trees has been assessed in 16 natural populations, seven of Q. robur, eight of Q. pedunculiflora and a mixed forest were both taxa coexist. In total, fifteen descriptors have been analysed by using discriminant analysis, while it was found that with only four out of the fifteen leaf traits (abaxial pubescence, abaxial colour of the leaf, petiole length and basal shape of lamina) the two taxa could be clearly differentiated...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28754494/safety-and-immunogenicity-of-a-mrna-rabies-vaccine-in-healthy-adults-an-open-label-non-randomised-prospective-first-in-human-phase-1-clinical-trial
#20
Martin Alberer, Ulrike Gnad-Vogt, Henoch Sangjoon Hong, Keyvan Tadjalli Mehr, Linus Backert, Greg Finak, Raphael Gottardo, Mihai Alexandru Bica, Aurelio Garofano, Sven Dominik Koch, Mariola Fotin-Mleczek, Ingmar Hoerr, Ralf Clemens, Frank von Sonnenburg
BACKGROUND: Vaccines based on mRNA coding for antigens have been shown to be safe and immunogenic in preclinical models. We aimed to report results of the first-in-human proof-of-concept clinical trial in healthy adults of a prophylactic mRNA-based vaccine encoding rabies virus glycoprotein (CV7201). METHODS: We did an open-label, uncontrolled, prospective, phase 1 clinical trial at one centre in Munich, Germany. Healthy male and female volunteers (aged 18-40 years) with no history of rabies vaccination were sequentially enrolled...
July 25, 2017: Lancet
keyword
keyword
87231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"