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Mustafa Zakkar, Vito Domanico Bruno, Alexandru Ciprian Visan, Stephanie Curtis, Gianni Angelini, Emmanuel Lansac, Serban Stoica
Aortic valve replacement is the gold standard for the management of patients with severe aortic stenosis or mixed pathology that is not amenable to repair according to currently available guidelines. Such a simplified approach may be suitable for many patients, but it is far from ideal for young adults considering emerging evidence demonstrating that conventional valve replacement in this cohort of patients is associated with inferior long-term survival when compared to the general population. Moreover; the utilisation of mechanical and bioprosthetic valves can significantly impact on quality and is linked to increased rates of morbidities...
2018: Frontiers in Surgery
Marius Alexandru Moga, Oana Gabriela Dimienescu, Cristian Andrei Arvătescu, Petru Ifteni, Liana Pleş
Cancer represents the disease of the millennium, a major problem in public health. The proliferation of tumor cells, angiogenesis, and the relationship between the cancer cells and the components of the extracellular matrix are important in the events of carcinogenesis, and these pathways are being used as targets for new anticancer treatments. Various venoms and their toxins have shown possible anticancer effects on human cancer cell lines, providing new perspectives in drug development. In this review, we observed the effects of natural toxins from bee and snake venom and the mechanisms through which they can inhibit the growth and proliferation of cancer cells...
March 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sabri Soussi, Marina Taccori, Christian De Tymowski, François Depret, Maïté Chaussard, Alexandre Fratani, Marion Jully, Alexandru Cupaciu, Axelle Ferry, Mourad Benyamina, Kevin Serror, David Boccara, Marc Chaouat, Maurice Mimoun, Pierre Cattan, Anne-Marie Zagdanski, James Anstey, Alexandre Mebazaa, Matthieu Legrand
OBJECTIVES: Burn-induced shock can lead to tissue hypoperfusion, including the gut. We performed this study to describe burn patients at risk of acute mesenteric ischemia (AMI) with the aim to identify potential modifiable risk factors. METHODS: Retrospective case-control study including adult severely burned patients between August 2012 and March 2017. Patients who developed AMI were matched to severely burned patients without AMI at a ratio of 1:3 (same year of admission, Abbreviated Burn Severity Index (ABSI) and Simplified Acute Physiology Score II (SAPSII))...
March 20, 2018: Shock
Takenobu Ishii, Montserrat Ruiz-Torruella, Atsushi Ikeda, Satoru Shindo, Alexandru Movila, Hani Mawardi, Abdullah Albassam, Rayyan A Kayal, Ayman A Al-Dharrab, Kenji Egashira, Wichaya Wisitrasameewong, Kenta Yamamoto, Abdulghani I Mira, Kenji Sueishi, Xiaozhe Han, Martin A Taubman, Takeshi Miyamoto, Toshihisa Kawai
Cell fusion-mediated formation of multinuclear osteoclasts (OCs) plays a key role in bone resorption. It is reported that 2 unique OC-specific fusogens [ i.e., OC-stimulatory transmembrane protein (OC-STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP)], and permissive fusogen CD9, are involved in OC fusion. Contrast to DC-STAMP of which knockout (KO) mice show osteopetrotic phenotype, OC-STAMP-KO mice show no difference in systemic bone mineral density. Nonetheless, according to the ligature-induced periodontitis model, significantly lower level of bone resorption was found in OC-STAMP-KO mice compared to WT mice...
March 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Angela Deyà-Martínez, Ana Esteve-Solé, Natalia Vélez-Tirado, Veronica Celis, Jordi Costa, Maria Cols, Cristina Jou, Alexandru Vlagea, Ana María Plaza-Martin, Manel Juan, Laia Alsina
BACKGROUND: One of the most frequent non-infectious complications of humoral immunodeficiencies with a CVID-like pattern is a particular form of inflammatory lung disease which is called granulomatous-lymphocytic interstitial lung disease (GLILD). Its development worsens patient prognosis, with a significant decrease in survival. Currently there are no unified guidelines regarding its management, and different combinations of immunosuppressants have been used with variable success. METHODS: Clinical and radiological data were collected from patient's medical charts...
March 12, 2018: Pediatric Allergy and Immunology
Ovidiu Musat, Stella Ioana Popescu, Corina Cristina Cernat, Ana Maria Boariu, Lucian Alexandru
This paper discusses a 32-year-old woman's case who presented a chronic decrease of visual acuity. In this case, the treatment was complex and consisted of a 25 GA vitrectomy, MLI peeling, covering the defect at the optic nerve papilla with that patch, gas endotamponade (C3F8). Abbreviations: MLI = internal limiting membrane; ODP-M = optic disc pit maculopathy.
October 2017: Romanian Journal of Ophthalmology
Alexandru I Tiba
No abstract text is available yet for this article.
2018: Frontiers in Psychology
Alexandru-Dan Sabău, Noor Hassan, Cătălin Gabriel Smarandache, Alin Miheţiu, Ștefan Ţîţu, Dan Sabău
PURPOSE: An original technique using laparoscopic instruments in a gastric endocavitary work chamber with potential for esophagus, stomach and D1 vizualisation. The main purpose of laparagastroscopy is to improve the quality of life of the patient disabling by the esophageal tumor. This method has several advantages: providing physiological feeding, harvesting materials for histopathological examination, solving eso-tracheal fistulas concurrently with the proposed operation and hemostatic role through compression, low energy and plastic consumption, rapid socio-economic reintegration, mental psychological care of the patient...
January 2018: Chirurgia
Alexandru Eugen Nicolau, Adrian Lobonţiu, Silviu Constantinoiu
GERD has become one of the most frequent pathology of the upper GI tract. It is a spectrum disease and is a progressive disease as well. Serious and severe complications are possible. The mainstream therapy in most of the patients is the medical therapy with PPI's. The most severe cases with an impaired LES (Lower Esophageal Sphincter) function as well as important anatomical disruptions are of surgical indication, the gold standard being laparoscopic fundoplication, an elective therapy with long term follow up outcomes at the expense of de novo symptoms associated with fundoplications in general...
January 2018: Chirurgia
Gunar Günther, Frank van Leth, Sofia Alexandru, Neus Altet, Korkut Avsar, Didi Bang, Raisa Barbuta, Graham Bothamley, Ana Ciobanu, Valeriu Crudu, Manfred Danilovits, Martin Dedicoat, Raquel Duarte, Gina Gualano, Heinke Kunst, Wiel de Lange, Vaira Leimane, Anne-Marie McLaughlin, Cecile Magis-Escurra, Inge Muylle, Veronika Polcová, Cristina Popa, Rudolf Rumetshofer, Alena Skrahina, Varvara Solodovnikova, Victor Spinu, Simon Tiberi, Piret Viiklepp, Christoph Lange
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in Europe. Reported treatment success rates are around 50% or less and cure rates are even lower. METHODS: We performed a prospective cohort study, analyzing management and treatment outcomes stratified by incidence of patients with MDR-TB in Europe. Treatment outcomes were compared by WHO and alternative simplified definitions. RESULTS: 380 patients with MDR-TB were recruited and followed-up between 2010 and 2014 in 16 European countries...
March 6, 2018: American Journal of Respiratory and Critical Care Medicine
Monique C Tourell, Ionut-Alexandru Pop, Lynda J Brown, Richard C D Brown, Giuseppe Pileio
Long-lived singlet order is exploited in diffusion NMR experiments to successfully measure the tortuosity of randomly packed spheres with diameters ranging from 500 to 1000 μm. The pore spaces in such packings have characteristic length scales well beyond the length scale limit set by spin relaxation in conventional NMR-diffusion experiments. Diffusion times of up to 240 s were used to obtain the restricted diffusion coefficient as a function of diffusion time in the long-time diffusion regime. Experimental results were validated with numerical simulations and data from X-ray micro-computed tomography...
March 6, 2018: Physical Chemistry Chemical Physics: PCCP
Ayana Ghosh, Lydie Louis, Alexandru D Asandei, Serge Nakhmanson
Spontaneous polarization P of mixed polymer crystals based on β poly(vinylidene fluoride) (PVDF, -CH2 -CF2 -) and 2,3,3,3-tetrafluoropropene (TFP, -CH2 -CF(CF3 )-) was evaluated for β-PVDF/iso-PTFP, β-PVDF/P(VDF-alt-iso-TFP) and β-PVDF/syndio-PTFP. A plane-wave-based density-functional theory (DFT) approach, combined with the Modern Theory of Polarization formalism utilizing maximally-localized Wannier functions for calculating P, indicates that all systems exhibit similarly high or even slightly larger polarization than that of perfectly crystalline β-PVDF (0...
March 2, 2018: Soft Matter
Qiqing Chen, Andreas Passos, Stavroula Balabani, Alexandru Chivu, Shudong Zhao, Helena S Azevedo, Peter Butler, Wenhui Song
Macroscopic hydrogels are commonly used as injectable scaffolds or fillers, however they may easily obstruct blood vessels, which poses risks and limits their clinical use. In the present study, three types of hyaluronic acid (HA)-based hydrogel micro-particles with non-covalent, covalent semi-interpenetrating and conventional 3D molecular networks, have been designed, fabricated and characterized. The micro-particles are spherical, biconcave or irregular in shape and their diameter ranged between 2.5 and 3...
February 16, 2018: Journal of Colloid and Interface Science
Alexandru Ulici, Daniel-Catalin Florea, Madalina Carp, Alin Ladaru, Iulia Tevanov
INTRODUCTION: Aneurysmal bone cyst (ABC) is a benign intraosseous lesion filled with blood that can determine a blowout distension of the bone. The purpose of this study is to evaluate the efficacy of sclerotherapy by percutaneous intralesional administration of ethanol 96% for the treatment of this pathology in paediatric patients. METHOD: The retrospective study includes 17 paediatric patients with ABC who were treated by repeated intracystic injection with ethanol 96%, 1 ml/kg, in our clinic between December 2015 and July 2017...
February 28, 2018: International Orthopaedics
Alexandru Filipescu, Irina Balescu, Nicolae Bacalbasa
Upper abdominal involvement in recurrent cervical cancer usually occurs as part of systemic disease and is most often amenable to palliative chemotherapy. However, in certain cases in which oligometastatic disease is proven, surgery might be considered. We present a case series of six patients submitted to surgery for upper abdominal oligometastases with cervical origin. The main surgical procedures performed included atypical hepatectomy (in five cases) and splenectomy (in one case). In all cases, the cervical origin of the lesions was revealed by histopathological studies...
March 2018: Anticancer Research
Khurshid Choudhry, David Armstrong, Alexandru Dregan
OBJECTIVES: To review current studies on obesity and weight within male prisoners. Including assessment of factors which influence obesity and weight change during imprisonment. STUDY DESIGN: A systematic review. METHODS: The systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. A literature search was conducted using defined exclusion and inclusion criteria for relevant studies published between 2000 and 2016...
February 22, 2018: Obesity Research & Clinical Practice
Santosh L Saraf, Justin R Sysol, Alexandru Susma, Suman Setty, Xu Zhang, Krishnamurthy P Gudehithlu, Jose A L Arruda, Ashok K Singh, Roberto F Machado, Victor R Gordeuk
Homozygosity for the hemoglobin (Hb) S mutation (HbSS, sickle cell anemia) results in hemoglobin polymerization under hypoxic conditions leading to vaso-occlusion and hemolysis. Sickle cell anemia affects 1:500 African Americans and is a strong risk factor for kidney disease, although the mechanisms are not well understood. Heterozygous inheritance (HbAS; sickle cell trait) affects 1:10 African Americans and is associated with an increased risk for kidney disease in some reports. Using transgenic sickle mice, we investigated the histopathologic, ultrastructural, and gene expression differences with the HbS mutation...
February 2, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Emilie Cordina-Duverger, Florence Menegaux, Alexandru Popa, Sylvia Rabstein, Volker Harth, Beate Pesch, Thomas Brüning, Lin Fritschi, Deborah C Glass, Jane S Heyworth, Thomas C Erren, Gemma Castaño-Vinyals, Kyriaki Papantoniou, Ana Espinosa, Manolis Kogevinas, Anne Grundy, John J Spinelli, Kristan J Aronson, Pascal Guénel
Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a...
February 20, 2018: European Journal of Epidemiology
Gerald W Prager, Sofia Braga, Branislav Bystricky, Camilla Qvortrup, Carmen Criscitiello, Ece Esin, Gabe S Sonke, Guillem Argilés Martínez, Jean-Sebastian Frenel, Michalis Karamouzis, Michiel Strijbos, Ozan Yazici, Paolo Bossi, Susana Banerjee, Teresa Troiani, Alexandru Eniu, Fortunato Ciardiello, Josep Tabernero, Christoph C Zielinski, Paolo G Casali, Fatima Cardoso, Jean-Yves Douillard, Svetlana Jezdic, Keith McGregor, Gracemarie Bricalli, Malvika Vyas, André Ilbawi
The cancer burden is rising globally, exerting significant strain on populations and health systems at all income levels. In May 2017, world governments made a commitment to further invest in cancer control as a public health priority, passing the World Health Assembly Resolution 70.12 on cancer prevention and control within an integrated approach. In this manuscript, the 2016 European Society for Medical Oncology Leadership Generation Programme participants propose a strategic framework that is in line with the 2017 WHO Cancer Resolution and consistent with the principle of universal health coverage, which ensures access to optimal cancer care for all people because health is a basic human right...
2018: ESMO Open
Constantin Streche, Diana Mariana Cocârţă, Irina-Aura Istrate, Adrian Alexandru Badea
Currently, there are different remediation technologies for contaminated soils, but the selection of the best technology must be not only the treatment efficiency but also the energy consumption (costs) during its application. This paper is focused on assessing energy consumption related to the electrochemical treatment of polluted soil with petroleum hydrocarbons. In the framework of a research project, two types of experiments were conducted using soil that was artificially contaminated with diesel fuel at the same level of contamination...
February 19, 2018: Scientific Reports
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