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https://www.readbyqxmd.com/read/28078579/immunoprecipitation-of-death-inducing-signaling-complex-by-caspase-8
#1
Andrei Alexandru Constentinescu, Aymeric Morlé, Olivier Micheau
Analysis of CD95/Fas complexes by immunoprecipitation has long relied on the monoclonal antibody APO1 or tagged recombinant Fas ligand. Immunoprecipitation is an elegant and efficient procedure to investigate endogenous protein interactions or complexes. Provided that the targeted complex is soluble in mild detergent these complexes can be recovered using protein A/G-coupled Sepharose beads and further analyzed after denaturation and electrophoretic separation by western blotting or mass spectrometry. Herein, we describe in detail the method used in our laboratory to immunoprecipitate and analyze by immunoblot complexes containing caspase-8, using a commercial antibody directed against caspase-8...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28077133/t1-and-t2-mapping-for-evaluation-of-myocardial-involvement-in-patients-with-anca-associated-vasculitides
#2
Simon Greulich, Agnes Mayr, Daniel Kitterer, Joerg Latus, Joerg Henes, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting with no or nonspecific symptoms, normal ECG, and preserved left-ventricular ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due to myocardial involvement, a reliable diagnostic tool is warranted. In contrast to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic processes, recent mapping techniques are able to detect even subtle, diffuse inflammatory or fibrotic processes...
January 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28070694/early-evaluation-and-monitoring-of-critical-patients-with-acute-respiratory-distress-syndrome-ards-using-specific-genetic-polymorphisms
#3
REVIEW
Florin G Horhat, Fuat Gundogdu, Laurentiu V David, Eugen S Boia, Laurentiu Pirtea, Razvan Horhat, Alexandru Cucui-Cozma, Ioana Ciuca, Mircea Diaconu, Razvan Nitu, Monica Licker, Delia I Horhat, Alexandru F Rogobete, Marius L Moise, Calin Tataru
A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases...
January 9, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28070693/micrornas-expression-as-novel-genetic-biomarker-for-early-prediction-and-continuous-monitoring-in-pulmonary-cancer
#4
REVIEW
Razvan Nitu, Alexandru Florin Rogobete, Fuat Gundogdu, Sonia Tanasescu, Ovidiu Boruga, Adriana Sas, Sonia Elena Popovici, Delia Hutanu, Ciprian Pilut, Cristian Andrei Sarau, Adrian Constantin Candea, Adrian Tudor Stan, Liviu Marius Moise
One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer...
January 9, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28045170/predicting-the-release-profile-of-small-molecules-from-within-the-ordered-nanostructured-lipidic-bicontinuous-cubic-phase-using-translational-diffusion-coefficients-determined-by-pfg-nmr
#5
Thomas G Meikle, Shenggen Yao, Alexandru Zabara, Charlotte E Conn, Calum J Drummond, Frances Separovic
The ordered nanostructured lipidic bicontinuous cubic phase has demonstrated potential as a drug release material, due to its ability to encapsulate a wide variety of compounds, which may undergo sustained, diffusion controlled release over time. Control of drug release has been shown to depend on the nanostructural parameters of the lipid mesophase. Herein, the diffusion and release of two amino acids, encapsulated within a range of different lipidic cubic mesophases are investigated. Pulsed-field gradient NMR was used to determine the diffusion coefficient of the encapsulated amino acid, which was found to be correlated with the nanoscale diameter of the water channels within the cubic mesophase...
January 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28045008/self-organization-and-forc-based-magnetic-characterization-of-ultra-high-aspect-ratio-epitaxial-co-nanostrips-produced-by-oblique-deposition-on-an-ordered-step-bunched-silicon-surface
#6
Alexey Ognev, Konstantin Ermakov, Aleksei Samardak, Ekaterina Sukovatitsina, Aleksey Kozlov, Aleksandr Davydenko, Ludmila Chebotkevich, Alexandru Stancu, Alexander S Samardak
Further development of microelectronics requires novel or improved technological approaches for a device nanofabrication and a functional properties characterization. In this paper we studied the crystal structure and magnetic properties of epitaxial Co nanostrips of the average width of 32.6, 45.3 and 62.6 nm grown on the step-bunched Si(111)5.55×5.55-Cu/Cu surface. Technological conditions, under which the ultra-high aspect ratio (∼10<sup>4</sup>) structurally solid, straight nanostrips of hcp-Co with crystallographic axis [0001] oriented along their long side can be grown, were determined...
January 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28044957/right-hemihepatectomy-for-colon-cancer-metachronous-liver-metastasis-in-a-patient-with-crohn-s-disease-case-report-and-review-of-the-literature
#7
Ionuţ Negoi, Alexandru Runcanu, Sorin Paun, Mircea Beuran
: Introduction: Twenty percent of patients with colorectal cancer present stage IV disease at the time of diagnosis. The Crohn's disease increases 20 times the risk of colorectal cancer and worsens the patients' prognosis. The objective of this case report is to illustrate the surgical resection of a liver metachronous metastasis of colon cancer origin in a patient with Crohn's disease. CASE REPORT: A 53-year old female patient was admitted to our hospital for a colon cancer metachronous liver metastasis...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28043695/standardizing-the-complication-rate-after-breast-reduction-using-the-clavien-dindo-classification
#8
Raimund Winter, Isabella Haug, Patricia Lebo, Martin Grohmann, Frederike M J Reischies, Janos Cambiaso-Daniel, Alexandru Tuca, Theresa Rienmüller, Herwig Friedl, Stephan Spendel, Abigail A Forbes, Paul Wurzer, Lars-P Kamolz
BACKGROUND: Published complication rates for breast reduction surgery, also known as reduction mammaplasty, vary between 4% and 54%. This wide range of complication rates could be attributable to the lack of a standardized classification of complications in plastic surgery. The aim of this study was to analyze our single-center complication rates after reduction mammaplasty using the Clavien-Dindo classification. METHODS: We performed a retrospective chart review studying 804 patients between the ages of 18 and 81 years old who underwent breast reduction between 2005 and 2015 at our institution...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28039489/trail-receptor-gene-editing-unveils-trail-r1-as-a-master-player-of-apoptosis-induced-by-trail-and-er-stress
#9
Florent Dufour, Thibault Rattier, Andrei Alexandru Constantinescu, Luciana Zischler, Aymeric Morlé, Hazem Ben Mabrouk, Etienne Humblin, Guillaume Jacquemin, Eva Szegezdi, Fabien Delacote, Naziha Marrakchi, Gilles Guichard, Catherine Pellat-Deceunynk, Pierre Vacher, Patrick Legembre, Carmen Garrido, Olivier Micheau
TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using the TALEN gene-editing approach, we show that TRAIL-R1 can also induce apoptosis during unresolved unfolded protein response (UPR). Likewise, TRAIL-R1 was found to co-immunoprecipitate with FADD and caspase-8 during ER stress. Its deficiency conferred resistance to apoptosis induced by thaspigargin, tunicamycin or brefeldin A...
27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28038729/2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts
#10
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castellá, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
January 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28033113/high-brachytherapy-doses-can-counteract-hypoxia-in-cervical-cancer-a-modelling-study
#11
Emely Lindblom, Alexandru Dasu, Catharina Beskow, Iuliana Toma-Dasu
Tumour hypoxia is a well-known adverse factor for the outcome of radiotherapy. For cervical tumours in particular, several studies indicate large variability in tumour oxygenation. However, clinical evidence shows that the management of cervical cancer including brachytherapy leads to high rate of success. It was the purpose of this study to investigate whether the success of brachytherapy for cervical cancer, seemingly regardless of oxygenation status, could be explained by the characteristics of the brachytherapy dose distributions...
December 29, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28030720/bleb-morphology-after-needling-with-viscoelastic-of-an-ab-interno-microstent-assessed-by-optical-coherence-tomography
#12
Andrei-Alexandru Szigiato, Matthew Schlenker, Iqbal Ike K Ahmed
No abstract text is available yet for this article.
January 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28013321/three-dimensional-model-of-the-skull-and-the-cranial-bones-reconstructed-from-ct-scans-designed-for-rapid-prototyping-process
#13
Janusz Skrzat, Alexandru Spulber, Jerzy Walocha
This paper presents the effects of building mesh models of the human skull and the cranial bones from a series of CT-scans. With the aid of computer so ware, 3D reconstructions of the whole skull and segmented cranial bones were performed and visualized by surface rendering techniques. The article briefly discusses clinical and educational applications of 3D cranial models created using stereolitographic reproduction.
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28009037/-2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts
#14
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
2016: Kardiologia Polska
https://www.readbyqxmd.com/read/28007093/bronchial-effects-of-cryoballoon-ablation-for-atrial-fibrillation
#15
Nishant Verma, Colin T Gillespie, A Christine Argento, Todd Tomson, Sanjay Dandamudi, Paloma Piña, Sukit Ringwala, Albert C Lin, Alexandru B Chicos, Susan Kim, Rishi Arora, Rod S Passman, Bradley P Knight
BACKGROUND: Damage to extracardiac structures, including the esophagus and phrenic nerve, is a known complication of cryoballoon ablation (CBA) during pulmonary vein (PV) isolation for atrial fibrillation (AF). Other adjacent structures, including the pulmonary bronchi and lung parenchyma, may be affected during CBA at the PV ostia. OBJECTIVE: The purpose of this study was to prospectively study the bronchial effects of CBA in humans undergoing CBA for PV isolation...
January 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28006671/recapitulation-of-treatment-response-patterns-in-a-novel-humanized-mouse-model-for-chronic-hepatitis-b-virus-infection
#16
Benjamin Y Winer, Tiffany Huang, Benjamin E Low, Cindy Avery, Mihai-Alexandru Pais, Gabriela Hrebikova, Evelyn Siu, Luis Chiriboga, Michael V Wiles, Alexander Ploss
There are ~350 million chronic carriers of hepatitis B (HBV). While a prophylactic vaccine and drug regimens to suppress viremia are available, chronic HBV infection is rarely cured. HBV's limited host tropism leads to a scarcity of susceptible small animal models and is a hurdle to developing curative therapies. Mice that support engraftment with human hepatoctyes have traditionally been generated through crosses of murine liver injury models to immunodeficient backgrounds. Here, we describe the disruption of fumarylacetoacetate hydrolase directly in the NOD Rag1(-/-) IL2RγNULL (NRG) background using zinc finger nucleases...
December 19, 2016: Virology
https://www.readbyqxmd.com/read/28002535/acute-cellulitis-as-local-reaction-to-orthopedic-implant-case-presentation
#17
Olivera Lupescu, Mihail Nagea, Răzvan Scurtu, Nicolae Marian Ciurea, Alexandru Lisias Dimitriu, Narcis Marcov, Gheorghe Ion Popescu, Simona Bondari
Due to increasing number of arthroplasties and osteosynthesis, foreign body reaction to implants is a major problem for orthopedic surgeons, since it is considered to be responsible for severe complications impairing the outcome of the treatment and requiring multiple surgery. Different mechanisms have been described as being involved, and research is focused on finding biomaterials with increased biocompatibility in order to minimize these complications. The clinical aspect of this reaction is usually dominated by chronic pain, with mild functional deficits, and the diagnosis results from excluding other causes of chronic pain, such as infection, osteoarthritis, peripheral neuropathies or angiopaties...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28002522/primary-retroperitoneal-seminoma-embryology-histopathology-and-treatment-particularities
#18
Constantin Virgil Gîngu, Mihaela Mihai, Cătălin Baston, Mugurel Alexandru Crăsneanu, Alexandru Vladimir Dick, Vlad Olaru, Ioanel Sinescu
INTRODUCTION: Retroperitoneal seminoma is a very rare form of cancer, with embryological origin represented by primordial germ cells from the urogenital ridges left behind during the fetal development. Extragenital germ cell tumors can also occur in the mediastinum or the pineal gland. The aim of this paper is to outline the particularities and draw embryological, histopatological and treatment conclusions regarding extragonadal germ cell tumors. PATIENT AND METHODS: A 43-year-old patient without any additional pathology was admitted for anemia of unknown etiology...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27994989/the-influence-of-the-menstrual-phases-on-polysomnography
#19
Andrew R Spector, Daniel Loriaux, Diana Alexandru, Sanford H Auerbach
PURPOSE:  The primary objective of this study is to determine how the phases of the menstrual cycle influence the results of polysomnography (PSG). METHODS:  Twenty-eight adult subjects who reported regular menstrual periods, last menstrual period (LMP) within 26 days of their PSG, no exogenous hormone use, no history of polycystic ovarian syndrome, and who were scheduled for diagnostic PSG at Boston Medical satisfied inclusion criteria for the study. These subjects were divided into a Follicular Cohort (days 0-13 of the cycle) or Luteal Cohort (days 14-26 of the cycle), and a one-way analysis using a t-test was performed to test the hypothesis that the follicular phase confers protection against obstructive sleep apnea (OSA)...
November 9, 2016: Curēus
https://www.readbyqxmd.com/read/27992533/grey-matter-microstructural-integrity-alterations-in-blepharospasm-are-partially-reversed-by-botulinum-neurotoxin-therapy
#20
Hanganu Alexandru, Muthuraman Muthuraman, Venkata Chaitanya Chirumamilla, Nabin Koirala, Burcu Paktas, Günther Deuschl, Kirsten E Zeuner, Sergiu Groppa
OBJECTIVE: Benign Essential Blepharospasm (BEB) and hemifacial spasm (HFS) are the most common hyperkinetic movement disorders of facial muscles. Although similar in clinical presentation different pathophysiological mechanisms are assumed. Botulinum Neurotoxin (BoNT) is a standard evidence-based treatment for both conditions. In this study we aimed to assess grey matter microstructural differences between these two groups of patients and compared them with healthy controls. In patients we furthermore tracked the longitudinal morphometric changes associated with BoNT therapy...
2016: PloS One
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