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https://www.readbyqxmd.com/read/28651016/enhanced-light-microscopy-visualization-of-virus-particles-from-zika-virus-to-filamentous-ebolaviruses
#1
George G Daaboul, David S Freedman, Steven M Scherr, Erik Carter, Alexandru Rosca, David Bernstein, Chad E Mire, Krystle N Agans, Thomas Hoenen, Thomas W Geisbert, M Selim Ünlü, John H Connor
Light microscopy is a powerful tool in the detection and analysis of parasites, fungi, and prokaryotes, but has been challenging to use for the detection of individual virus particles. Unlabeled virus particles are too small to be visualized using standard visible light microscopy. Characterization of virus particles is typically performed using higher resolution approaches such as electron microscopy or atomic force microscopy. These approaches require purification of virions away from their normal millieu, requiring significant levels of expertise, and can only enumerate small numbers of particles per field of view...
2017: PloS One
https://www.readbyqxmd.com/read/28643628/real-time-whole-genome-sequencing-for-surveillance-of-listeria-monocytogenes-france
#2
Alexandra Moura, Mathieu Tourdjman, Alexandre Leclercq, Estelle Hamelin, Edith Laurent, Nathalie Fredriksen, Dieter Van Cauteren, Hélène Bracq-Dieye, Pierre Thouvenot, Guillaume Vales, Nathalie Tessaud-Rita, Mylène M Maury, Andreea Alexandru, Alexis Criscuolo, Emmanuel Quevillon, Marie-Pierre Donguy, Vincent Enouf, Henriette de Valk, Sylvain Brisse, Marc Lecuit
During 2015-2016, we evaluated the performance of whole-genome sequencing (WGS) as a routine typing tool. Its added value for microbiological and epidemiologic surveillance of listeriosis was compared with that for pulsed-field gel electrophoresis (PFGE), the current standard method. A total of 2,743 Listeria monocytogenes isolates collected as part of routine surveillance were characterized in parallel by PFGE and core genome multilocus sequence typing (cgMLST) extracted from WGS. We investigated PFGE and cgMLST clusters containing human isolates...
September 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28641917/complications-in-tissue-expansion-a-logistic-regression-analysis-for-risk-factors
#3
Christian Smolle, Alexandru Tuca, Paul Wurzer, Stephanie M Spendel, Abigail A Forbes, Stephan Spendel, Michael Schintler, Emir Haxhija, Katja Schwenzer-Zimmerer, Herwig Friedl, Lars-Peter Kamolz, Daryousch Parvizi
BACKGROUND: Tissue expansion is frequently used in reconstructive surgery. Although the surgical procedure is typically considered simple, reported complication rates of tissue expansions exceed 40%. There is little evidence concerning risk factors for complications in tissue expansion in body regions other than breast. The aim was to determine risk factors for complications in non-breast tissue expansion. METHODS: 34 patients treated with subcutaneous tissue expanders between 2005 and 2014 were analyzed...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28637359/decreased-paraoxonase-2-enzymatic-activity-in-monocyte-macrophages-cells-a-comparative-in-vivo-and-in-vitro-study-for-diabetes
#4
D Lixandru, P Alexandru, A Mihai, A Roşca, C Ionescu-Tîrgovişte, L I Braşoveanu, B Manuel-Y-Keenoy
Aim To investigate peripheral blood monocytes/macrophages (Mo/Mø) paraoxonase2 (PON2) in diabetes and the factors modulating its activity. Methods 118 patients with newly diagnosed uncomplicated type 2 diabetes mellitus were compared regarding clinical, biochemical and oxidative stress parameters with 80 healthy subjects. The capacity of the peripheral blood mononuclear cells (PBMNC) to release pro-oxidants and to neutralize them was determined by measuring the respiratory burst (RB) and the intracellular antioxidant enzyme PON2...
June 21, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28633726/small-bowel-intussusception-in-a-pregnant-woman-a-case-report
#5
Roxana Covali, Lucian Ambrosie, Micea Onofriescu, Alexandru Luca, Gabriela Dumachita-Sargu, Violeta Aursulesei, Dumitru Gafitanu
INTRODUCTION: Intussusception usually is associated with children, rarely with adults. CASE PRESENTATION: A 42-year-old pregnant woman (29 weeks' gestation) reported mild pain in the upper aspect of the abdomen after an intense physical effort. Ultrasound examination found a normally evolving pregnancy and a bowel obstacle, without bowel distention. Because it was not a surgical emergency at the time of evaluation, she was sent to the hospital's Obstetrics Department...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28629130/optimization-of-polyplex-formation-between-dna-oligonucleotide-and-poly-%C3%AA-lysine-experimental-study-and-modeling-approach
#6
Tudor Vasiliu, Corneliu Cojocaru, Alexandru Rotaru, Gabriela Pricope, Mariana Pinteala, Lilia Clima
The polyplexes formed by nucleic acids and polycations have received a great attention owing to their potential application in gene therapy. In our study, we report experimental results and modeling outcomes regarding the optimization of polyplex formation between the double-stranded DNA (dsDNA) and poly(ʟ-Lysine) (PLL). The quantification of the binding efficiency during polyplex formation was performed by processing of the images captured from the gel electrophoresis assays. The design of experiments (DoE) and response surface methodology (RSM) were employed to investigate the coupling effect of key factors (pH and N/P ratio) affecting the binding efficiency...
June 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627836/dna-based-identification-of-a-carbonized-victim-by-kinship-analysis
#7
Raluca Dumache, Alexandru F Rogobete, Veronica Ciocan, Camelia O Muresan, Alexandra Enache
BACKGROUND: Our study will present the DNA identification of a carbonized victim using the DNA genotyping and by comparing the victim's DNA genotype with his parents' genotypes. METHODS: Blood obtained from the heart chambers was used for the identification of the carbonized body's genotype. Biological samples were also obtained by buccal swabs from his biological parents. We used an ABI 7500 real-time PCR system for quantification and a ProFlex PCR System to amplify...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627816/spectrophotometric-determination-of-selenium-through-triiodide-anion
#8
Otilia Bizerea-Spiridon, Radu Nartita, Alexandru F Rogobete, Adina Negrea, Ramona Stroescu, Teofana O Bizerea, Constantin Ilie, Otilia Marginean
BACKGROUND: Selenium is a chemical element found in the human body that plays a crucial role in its regulation. Depending on the concentration, it may have beneficial or have toxic effects. Selenium is incorporated as selenocysteine amino acid residue in selenoproteins which play an important role in many biological functions: anti-oxidant defense, regulation of the immune function and of the inflammatory response, metabolism of thyroid hormones, functioning of the central nervous system, biosynthesis of DNA and RNA, fertility, and reproduction...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28620435/to-sleep-or-not-to-sleep-that-is-the-question-for-polysomnography
#9
Alexandru Corlateanu, Serghei Covantev, Victor Botnaru, Victoria Sircu, Raffaella Nenna
Have we reached the point where respiratory polygraphy can replace polysomnography in the assessment of OSAS? http://ow.ly/UxCU30bNopq.
June 2017: Breathe
https://www.readbyqxmd.com/read/28614304/particle-physics-no-sign-of-asymmetry-in-the-strong-force
#10
Alexandru Florin Dobrin
No abstract text is available yet for this article.
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28612033/estimation-of-mode-effects-in-the-health-and-retirement-study-using-measurement-models
#11
Alexandru Cernat, Mick P Couper, Mary Beth Ofstedal
Using multiple modes to collect data is becoming a standard practice in survey agencies. While this should lower costs and reduce non-response error it may have detrimental effects on measurement quality. This is of special concern in panel surveys where a key focus is on measuring change over time and where changing modes may have an effect on key measures. In this paper we use a quasi-experimental design from the Health and Retirement Study to compare the measurement quality of two scales between face-to-face, telephone and Web modes...
December 2016: Journal of Survey Statistics and Methodology
https://www.readbyqxmd.com/read/28609703/etiologic-classification-of-ischemic-stroke-where-do-we-stand
#12
REVIEW
Răzvan Alexandru Radu, Elena Oana Terecoasă, Ovidiu Alexandru Băjenaru, Cristina Tiu
Despite major technological advances in ischemic stroke diagnostic techniques, our current understanding of stroke mechanisms and etiology continues to remain unclear in a significant percent of patients. As a result, several etiological ischemic stroke classifications have emerged during the last two decades but their reliability and validity is far from perfect and further world-wide research is needed in order to achieve the so much needed "standard reference language". An ideal ischemic stroke classification should both comprise all underlying pathologies that could potentially concur to an index event and emphasize the most likely etiological and pathophysiological mechanism...
May 24, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28609579/diffusion-mri-and-the-detection-of-alterations-following-traumatic-brain-injury
#13
REVIEW
Elizabeth B Hutchinson, Susan C Schwerin, Alexandru V Avram, Sharon L Juliano, Carlo Pierpaoli
This article provides a review of brain tissue alterations that may be detectable using diffusion magnetic resonance imaging MRI (dMRI) approaches and an overview and perspective on the modern dMRI toolkits for characterizing alterations that follow traumatic brain injury (TBI). Noninvasive imaging is a cornerstone of clinical treatment of TBI and has become increasingly used for preclinical and basic research studies. In particular, quantitative MRI methods have the potential to distinguish and evaluate the complex collection of neurobiological responses to TBI arising from pathology, neuroprotection, and recovery...
June 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28609497/retrospective-case-series-analysis-to-evaluate-ridge-augmentation-procedure-applied-to-immediate-implant-placement-in-the-esthetic-zone-five-year-longitudinal-evaluation-using-cone-beam-computed-tomography
#14
Yasuhiro Takai, Kazuhisa Ouhara, Alexandru Movila, Toshihisa Kawai
Using simultaneous transplantation of bone graft materials, this study examined the long-term outcomes of a ridge augmentation technique applied to deficient labial alveolar bone plate in the esthetic zone. Results were based on a case series in which study cases (n = 10) were divided into two groups. Group 1 exhibited intact labial alveolar bone, while group 2 alveolar bone was dehiscent at the labial aspect. The clinical outcome was longitudinally monitored using cone beam computed tomography 4 to 7 years after the procedure...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28606833/impact-of-physiological-breathing-motion-for-breast-cancer-radiotherapy-with-proton-beam-scanning-an-in-silico-study
#15
Anna M Flejmer, Behnaz Chehrazi, Dan Josefsson, Iuliana Toma-Dasu, Alexandru Dasu
This study investigates the impact of breathing motion on proton breast treatment plans. Twelve patients with CT datasets acquired during breath-hold-at-inhalation (BHI), breath-hold-at-exhalation (BHE) and in free-breathing (FB) were included in the study. Proton plans were designed for the left breast for BHI and subsequently recalculated for BHE or designed for FB and recalculated for the extreme breath-hold phases. The plans were compared from the point of view of their target coverage and doses to organs-at-risk...
June 9, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28605109/a-randomized-double-blind-placebo-and-risperidone-controlled-study-on-valnoctamide-for-acute-mania
#16
Mark Weiser, Linda Levi, Stephen Z Levine, Meir Bialer, Tawfeeq Shekh-Ahmad, Valentin Matei, Alexandru Tiugan, Diana Cirjaliu, Cristinel Sava, Eugenia Sinita, Daisy Zamora, John M Davis
OBJECTIVES: Mood stabilizers administered for bipolar disorder during pregnancy, such as valproic acid, can increase the risk of congenital anomalies in offspring. Valnoctamide is a valproic acid derivative associated with a decreased risk for congenital abnormalities in animals. The present study evaluated the efficacy and safety of valnoctamide monotherapy, compared to placebo, in the treatment of patients in an acute manic episode. METHODS: A 3-week, double-blind, randomized, placebo- and risperidone-controlled, parallel group trial was conducted on 173 patients in an acute manic episode...
June 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28602688/quality-control-in-cone-beam-computed-tomography-cbct-efomp-estro-iaea-protocol-summary-report
#17
Hugo de Las Heras Gala, Alberto Torresin, Alexandru Dasu, Osvaldo Rampado, Harry Delis, Irene Hernández Girón, Chrysoula Theodorakou, Jonas Andersson, John Holroyd, Mats Nilsson, Sue Edyvean, Vesna Gershan, Lama Hadid-Beurrier, Christopher Hoog, Gregory Delpon, Ismael Sancho Kolster, Primož Peterlin, Julia Garayoa Roca, Paola Caprile, Costas Zervides
The aim of the guideline presented in this article is to unify the test parameters for image quality evaluation and radiation output in all types of cone-beam computed tomography (CBCT) systems. The applications of CBCT spread over dental and interventional radiology, guided surgery and radiotherapy. The chosen tests provide the means to objectively evaluate the performance and monitor the constancy of the imaging chain. Experience from all involved associations has been collected to achieve a consensus that is rigorous and helpful for the practice...
June 8, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28599908/fluorescein-angiography-in-intracranial-aneurysm-surgery-a-helpful-method-to-evaluate-the-security-of-clipping-and-to-observe-blood-flow
#18
Cristian Kakucs, Ioan-Alexandru Florian, Gheorghe Ungureanu, Ioan-Stefan Florian
OBJECTIVE: In cerebral aneurysm surgery, a number of tools are employed to evaluate blood flow, such as Doppler ultrasonography, conventional cerebral angiography, and electrophysiological monitoring. Fluorescein and indocyanine green are widely used in vascular and central nervous system tumor neurosurgery. Nevertheless, their routine utilization in aneurysmal surgery is uncommon, despite the fact that they allow direct visualization of blood flow after an aneurysmal sac occlusion, enabling the observation of vessel permeability and the effectiveness of aneurysmal obliteration...
June 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28593987/spaser-as-a-biological-probe
#19
Ekaterina I Galanzha, Robert Weingold, Dmitry A Nedosekin, Mustafa Sarimollaoglu, Jacqueline Nolan, Walter Harrington, Alexander S Kuchyanov, Roman G Parkhomenko, Fumiya Watanabe, Zeid Nima, Alexandru S Biris, Alexander I Plekhanov, Mark I Stockman, Vladimir P Zharov
Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28592386/ct-p6-compared-with-reference-trastuzumab-for-her2-positive-breast-cancer-a-randomised-double-blind-active-controlled-phase-3-equivalence-trial
#20
Justin Stebbing, Yauheni Baranau, Valeriy Baryash, Alexey Manikhas, Vladimir Moiseyenko, Giorgi Dzagnidze, Edvard Zhavrid, Dmytro Boliukh, Daniil Stroyakovskii, Joanna Pikiel, Alexandru Eniu, Dmitry Komov, Gabriela Morar-Bolba, Rubi K Li, Andriy Rusyn, Sang Joon Lee, Sung Young Lee, Francisco J Esteva
BACKGROUND: CT-P6 is a proposed biosimilar to reference trastuzumab. In this study, we aimed to establish equivalence of CT-P6 to reference trastuzumab in neoadjuvant treatment of HER2-positive early-stage breast cancer. METHODS: In this randomised, double-blind, active-controlled, phase 3 equivalence trial, we recruited women aged 18 years or older with stage I-IIIa operable HER2-positive breast cancer from 112 centres in 23 countries. Inclusion criteria were an Eastern Cooperative Oncology Group performance status score of 0 or 1; a normal left ventricular ejection fraction of at least 55%; adequate bone marrow, hepatic, and renal function; at least one measureable lesion; and known oestrogen and progesterone receptor status...
June 2, 2017: Lancet Oncology
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