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https://www.readbyqxmd.com/read/29160765/antithrombotic-treatment-in-peripheral-artery-disease
#1
Dan-Mircea Olinic, Dan Alexandru Tataru, Calin Homorodean, Mihail Spinu, Maria Olinic
This review treats antithrombotic use for peripheral arterial disease (PAD). In asymptomatic patients, there are no scientific data to support single antiplatelet therapy (SAPT) for primary prophylaxis. In symptomatic PAD, SAPT with aspirin or clopidogrel is indicated. The efficacy of aspirin is controversial. Clopidogrel may be preferred over aspirin. Ticagrelor is not superior to clopidogrel in reducing major adverse cardiovascular events and major adverse limb events, but lowers the risk of ischaemic stroke...
November 21, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29159185/design-and-testing-of-an-experimental-steam-induced-burn-model-in-rats
#2
Vlad Porumb, Alexandru Florentin Trandabăț, Cristina Terinte, Irina Draga Căruntu, Elena Porumb-Andrese, Mihail Gabriel Dimofte, Dragoş Pieptu
Background: Most of the current models for experimental burns pose difficulties in ensuring consistency and standardization. Aim of Study: We aimed to develop an automated, reproducible technique for experimental burns using steam-based heat transfer. Methods: The system developed for steam exposure was based on a novel, integrated, computer-controlled design. Three groups of rats were exposed to steam for 1, 3, and 7 seconds. The lesions were evaluated after 20 minutes, 48 hours, and 72 hours after burn induction...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29157036/epigallocatechin-3-o-gallate-alleviates-the-malignant-phenotype-in-a-431-epidermoid-and-sk-br-3-breast-cancer-cell-lines
#3
Alexandru Filippi, Tiphanie Picot, Carmen Mariana Aanei, Péter Nagy, János Szöllősi, Lydia Campos, Constanţa Ganea, Maria-Magdalena Mocanu
In this study, we evaluated the effects of epigallocatechin-3-O-gallate (EGCG) in two cancer cell lines, A-431 overexpressing ErbB1 and SK-BR-3, overexpressing ErbB2. EGCG treatment showed dose-dependent collapse of mitochondrial membrane potential (Δψm), increase in reactive oxygen species (ROS) production, changes in nuclear morphology and reduced viability. Flow cytometry data indicated that EGCG partially decreases the phosphorylation of several proteins involved in cell proliferation and survival: pErbB1(Y1173, Y1068), pAkt(S473) and pERK(Y204)...
November 21, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29156646/inhibition-of-bcl-2-and-cox-2-protein-expression-after-local-application-of-a-new-carmustine-loaded-clinoptilolite-based-delivery-system-in-a-chemically-induced-skin-cancer-model-in-mice
#4
Cristina Mihaela Ghiciuc, Aurel Lulu Strat, Lacramioara Ochiuz, Catalina Elena Lupusoru, Maria Ignat, Aurelia Vasile, Alexandru Grigorovici, Iulian Stoleriu, Carmen Solcan
Our research has focused on in vitro and in vivo evaluations of a new Carmustine (BCNU)-loaded clinoptilolite-based delivery system. Two clinoptilolite ionic forms-hydrogen form (HCLI) and sodium form (NaCLI)-were prepared, allowing a loading degree of about 5-6 mg BCNU/g of zeolite matrix due to the dual porous feature of clinoptilolite. Clinoptilolite-based delivery systems released 35.23% of the load in 12 h for the BCNU@HCLI system and only 10.82% for the BCNU@NaCLI system. The BCNU@HCLI system was chosen to develop gel and cream semisolid dosage forms...
November 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29155719/exploring-deep-space-uncovering-the-anatomy-of-periventricular-structures-to-reveal-the-lateral-ventricles-of-the-human-brain
#5
Alexandru S Colibaba, Aicee Dawn B Calma, Alexandra L Webb, Krisztina Valter
Anatomy students are typically provided with two-dimensional (2D) sections and images when studying cerebral ventricular anatomy and students find this challenging. Because the ventricles are negative spaces located deep within the brain, the only way to understand their anatomy is by appreciating their boundaries formed by related structures. Looking at a 2D representation of these spaces, in any of the cardinal planes, will not enable visualisation of all of the structures that form the boundaries of the ventricles...
October 22, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155057/effects-of-different-hypoxia-degrees-on-endothelial-cell-cultures-time-course-study
#6
Ioana Baldea, Ioana Teacoe, Diana Elena Olteanu, Cristina Vaida-Voievod, Andra Clichici, Alexandru Sirbu, Gabriela Adriana Filip, Simona Clichici
INTRODUCTION: Exposure of the endothelial cells to hypoxia, the decrease in oxygen supply can trigger an endothelial response. This response is involved in inflammatory diseases, tumorigenesis, and also with the micro vascular damage associated with aging. The aim of our study was to determine the hypoxia/re-oxygenation induced response in vitro, using human umbilical vein endothelial cells (HUVEC) cultures, at different time points with focus on cell viability, apoptosis oxidative stress and angiogenesis stimulation...
November 15, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29151796/association-of-fragile-x-syndrome-robertsonian-translocation-13-22-and-autism-in-a-child
#7
Andreea Liana Rachisan, Alexandru Stefan Niculae, Ioana Tintea, Bianca Pop, Mariela Militaru, Aurel Bizo, Adrian Hrusca
We describe the case of a 6-year-old boy with both fragile X syndrome and Robertsonian Translocation (45, XY, der (13; 22) (q10; q10)). This is the first reported case of a patient with fragile X syndrome with this Robertsonian translocation. Facial features and macroorchidism were consistent with fragile X syndrome. Cognitive impairment is more significant than in his sibling with fragile X syndrome, and the patient also has a prior diagnosis of autism spectrum disorder. We emphasize the challenges in his behavioral management and outline future directions for his management...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29151787/infantile-hemangiomas-a-7-year-experience-of-a-single-center
#8
Mădălina Bota, Gheorghe Popa, Cristina Lucia Blag, Daniel-Corneliu Leucuta, Alexandru Tătaru
Objectives: The aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic. Methods: This is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic. Results: We had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Almost two-thirds involved the cephalic extremity, and 76% of the cases were treated. Pregnancy risk factors included prematurity, low-birth weight and respiratory distress syndrome...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29150714/stochastic-lotka-volterra-food-chains
#9
Alexandru Hening, Dang H Nguyen
We study the persistence and extinction of species in a simple food chain that is modelled by a Lotka-Volterra system with environmental stochasticity. There exist sharp results for deterministic Lotka-Volterra systems in the literature but few for their stochastic counterparts. The food chain we analyze consists of one prey and [Formula: see text] predators. The jth predator eats the [Formula: see text]th species and is eaten by the [Formula: see text]th predator; this way each species only interacts with at most two other species-the ones that are immediately above or below it in the trophic chain...
November 17, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29149390/decompressive-craniectomy-and-csf-disorders-in-children
#10
Marie Manfiotto, Carmine Mottolese, Alexandru Szathmari, Pierre-Aurelien Beuriat, Olivier Klein, Matthieu Vinchon, Edouard Gimbert, Thomas Roujeau, Didier Scavarda, Michel Zerah, Federico Di Rocco
INTRODUCTION: Decompressive craniectomy (DC) is a lifesaving procedure but is associated to several post-operative complications, namely cerebrospinal fluid (CSF) dynamics impairment. The aim of this multicentric study was to evaluate the incidence of such CSF alterations after DC and review their impact on the overall outcome. MATERIAL AND METHODS: We performed a retrospective multicentric study to analyze the CSF disorders occurring in children aged from 0 to 17 years who had undergone a DC for traumatic brain injury (TBI) in the major Departments of Pediatric Neurosurgery of France between January 2006 and August 2016...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29141489/non-linear-conversion-of-hx4-uptake-for-automatic-segmentation-of-hypoxic-volumes-and-dose-prescription
#11
Ana Ureba, Emely Lindblom, Alexandru Dasu, Johan Uhrdin, Aniek J G Even, Wouter van Elmpt, Philippe Lambin, Peter Wersäll, Iuliana Toma-Dasu
BACKGROUND: Tumour hypoxia is associated with increased radioresistance and poor response to radiotherapy. Pre-treatment assessment of tumour oxygenation could therefore give the possibility to tailor the treatment by calculating the required boost dose needed to overcome the increased radioresistance in hypoxic tumours. This study concerned the derivation of a non-linear conversion function between the uptake of the hypoxia-PET tracer (18)F-HX4 and oxygen partial pressure (pO2). MATERIAL AND METHODS: Building on previous experience with FMISO including experimental data on tracer uptake and pO2, tracer-specific model parameters were derived for converting the normalised HX4-uptake at the optimal imaging time point to pO2...
November 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29135125/follicle-stimulating-hormone-receptors-a-new-immunohistochemical-marker-in-cancers
#12
Eduard-Alexandru Bonci, Alexandru Irimie, Rares Buiga, Ioan Cosmin Lisencu, Laura Iuliana Maja, Doina Piciu
PURPOSE: Follicle-stimulating hormone receptors (FSHR) have been reported in ovarian cancer and prostate cancer cells, but recent studies have highlighted their presence in the endothelium of blood vessels belonging to multiple neoplasias. Current research attempts to determine the role of FSHR in neoplastic proliferation and possible therapeutic or diagnostic implications. This paper aimed to analyze articles that have revealed the presence and/or role of FSHR in various neoplasms in humans...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135092/the-prognostic-role-of-skp2-and-the-tumor-suppressor-protein-p27-in-colorectal-cancer
#13
Ovidiu Vasile Bochis, Patriciu Achimas-Cadariu, Catalin Vlad, Bogdan Fetica, Daniel Corneliu Leucuta, Constantin Ioan Busuioc, Alexandru Irimie
PURPOSE: This study aimed at exploring the role of Skp2, p27 and Cks1 expression as prognostic factors for colorectal cancer (CRC) patients, and to identify a correlation between their expression and the cell proliferation marker Ki67. METHODS: We conducted a retrospective study on 130 patients with CRC treated with surgery and adjuvant treatment at the Oncology Institute Cluj-Napoca between 2006- 2010. The Skp2, p27, Cks1 and Ki67 immunoexpression was grouped from 1 to 4, according to percents of tumor cells with nuclear reactivity...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29131208/g-quartet-hydrogels-for-effective-cell-growth-applications
#14
Alexandru Rotaru, Gabriela Pricope, Taylor N Plank, Lilia Clima, Elena L Ursu, Mariana Pinteala, Jeffery T Davis, Mihail Barboiu
Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg(2+) support cell growth with no visible signs of gel degradation.
November 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29129718/lessons-in-protac-design-from-selective-degradation-with-a-promiscuous-warhead
#15
Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews
Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we report a previously understudied benefit of small molecule proteolysis-targeting chimeras (PROTACs) that recruit E3 ubiquitin ligases to target proteins for their ubiquitination and subsequent proteasome-mediated degradation. Using promiscuous CRBN- and VHL-recruiting PROTACs that bind >50 kinases, we show that only a subset of bound targets is degraded. The basis of this selectivity relies on protein-protein interactions between the E3 ubiquitin ligase and the target protein, as illustrated by engaged proteins that are not degraded as a result of unstable ternary complexes with PROTAC-recruited E3 ligases...
November 9, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29128422/ampholytic-starch-excipients-for-high-loaded-drug-formulations-mechanistic-insights
#16
Khalil Sakeer, Pompilia Ispas-Szabo, Nassim Benyerbah, Mircea Alexandru Mateescu
Ampholytic starch derivatives are proposed as a new class of excipients carrying simultaneously anionic carboxymethyl (CM) and cationic aminoethyl (AE) groups on starch (St) polymeric chains. Three different types of derivatives were obtained by using the same reagents and varying only the order of their addition in the reaction medium: in one step method (OS) the two reactants were added simultaneously, whereas in two steps method (TS) either CMSt or AESt were prepared separately in the first step, followed by subsequent addition of the second reactant...
November 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29127666/care-for-mental-health-of-caribbean-medical-students
#17
Richard Balon, Alexandru Cojanu, Mary K Morreale
No abstract text is available yet for this article.
November 10, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/29124514/anaerobic-microplate-assay-for-direct-microbial-conversion-of-switchgrass-and-avicel-using-clostridium-thermocellum
#18
Gbekeloluwa B Oguntimein, Miguel Rodriguez, Alexandru Dumitrache, Todd Shollenberger, Stephen R Decker, Brian H Davison, Steven D Brown
OBJECTIVE: To develop and prototype a high-throughput microplate assay to assess anaerobic microorganisms and lignocellulosic biomasses in a rapid, cost-effective screen for consolidated bioprocessing potential. RESULTS: Clostridium thermocellum parent Δhpt strain deconstructed Avicel to cellobiose, glucose, and generated lactic acid, formic acid, acetic acid and ethanol as fermentation products in titers and ratios similar to larger scale fermentations confirming the suitability of a plate-based method for C...
November 9, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29121040/ossification-of-the-petrosphenoid-ligament-a-case-study
#19
Janusz Skrzat, Izabela Mróz, Alexandru Spulber, Michał Zarzecki, Jerzy Walocha
The current study presents a case in which a human skull revealed a partially ossified petrosphenoid ligament. The ossified ligament appears as a hooked bony trabecula emerging below the right posterior clinoid process. Another bony trabecula arises from the petrous apex and runs towards the clivus. Both trabecula face each other but do not fuse, having a small gap between their tips. Their positions clearly indicate that they must have formed an overhang above the abducens nerve. Therefore, they should be considered a part of the walls of Dorello's canal, which is a conduit for the abducens nerve and associated vascular structures...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29120427/fully-integrated-silicon-probes-for-high-density-recording-of-neural-activity
#20
James J Jun, Nicholas A Steinmetz, Joshua H Siegle, Daniel J Denman, Marius Bauza, Brian Barbarits, Albert K Lee, Costas A Anastassiou, Alexandru Andrei, Çağatay Aydın, Mladen Barbic, Timothy J Blanche, Vincent Bonin, João Couto, Barundeb Dutta, Sergey L Gratiy, Diego A Gutnisky, Michael Häusser, Bill Karsh, Peter Ledochowitsch, Carolina Mora Lopez, Catalin Mitelut, Silke Musa, Michael Okun, Marius Pachitariu, Jan Putzeys, P Dylan Rich, Cyrille Rossant, Wei-Lung Sun, Karel Svoboda, Matteo Carandini, Kenneth D Harris, Christof Koch, John O'Keefe, Timothy D Harris
Sensory, motor and cognitive operations involve the coordinated action of large neuronal populations across multiple brain regions in both superficial and deep structures. Existing extracellular probes record neural activity with excellent spatial and temporal (sub-millisecond) resolution, but from only a few dozen neurons per shank. Optical Ca(2+) imaging offers more coverage but lacks the temporal resolution needed to distinguish individual spikes reliably and does not measure local field potentials. Until now, no technology compatible with use in unrestrained animals has combined high spatiotemporal resolution with large volume coverage...
November 8, 2017: Nature
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