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https://www.readbyqxmd.com/read/28341107/comparison-of-clinical-effects-of-epidural-levobupivacaine-morphine-versus-bupivacaine-morphine-in-dogs-undergoing-elective-pelvic-limb-surgery
#1
Ilaria Cerasoli, Alexandru Tutunaru, Alessia Cenani, Juan Ramirez, Johann Detilleux, Marc Balligand, Charlotte Sandersen
OBJECTIVE: To evaluate the efficacy, in terms of the amount of rescue analgesia required, and the clinical usefulness of epidural injection of morphine with bupivacaine or levobupivacaine for elective pelvic limb surgery in dogs during a 24-hour perioperative period. STUDY DESIGN: Prospective, blinded, randomized clinical study. ANIMALS: A group of 26 dogs weighing 31.7 ± 14.2 (mean ± standard deviation) kg and aged 54 ± 36 months. METHODS: All dogs were premedicated with methadone intravenously (0...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28339233/glue-spin-and-helicity-in-the-proton-from-lattice-qcd
#2
Yi-Bo Yang, Raza Sabbir Sufian, Andrei Alexandru, Terrence Draper, Michael J Glatzmaier, Keh-Fei Liu, Yong Zhao
We report the first lattice QCD calculation of the glue spin in the nucleon. The lattice calculation is carried out with valence overlap fermions on 2+1 flavor domain-wall fermion gauge configurations on four lattice spacings and four volumes including an ensemble with physical values for the quark masses. The glue spin S_{G} in the Coulomb gauge in the modified minimal subtraction (MS[over ¯]) scheme is obtained with one-loop perturbative matching. We find the results fairly insensitive to lattice spacing and quark masses...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28338114/molecular-analysis-of-vascular-endothelial-growth-factor-vegf-receptors-in-eus-guided-samples-obtained-from-patients-with-pancreatic-adenocarcinoma
#3
Madalin Ionut Costache, Sevastita Iordache, Cornelia Alexandra Costache, Ene Dragos, Alexandru Dragos, Adrian Saftoiu
BACKGROUND AND AIMS: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and VEGF-R2) are the most important angiogenesis stimulating factors in pancreatic cancer. This study aims to assess VEGF-R1 and VEGF-R2 gene expression in EUS-FNA samples and identify prognostic markers in pancreatic adenocarcinoma. METHODS: This was a retrospective study of prospectively collected data of 88 consecutive patients, with clinical and imaging suspicion of pancreatic neoplasms, based on samples obtained through endoscopic ultrasound-guided fine needle aspiration (EUS-FNA)...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28334100/an-organismal-concept-for-sengelia-radicans-gen-et-sp-nov-morphology-and-natural-history-of-an-early-devonian-lycophyte
#4
Kelly K S Matsunaga, Alexandru M F Tomescu
Background and Aims: Fossil plants are found as fragmentary remains and understanding them as natural species requires assembly of whole-organism concepts that integrate different plant parts. Such concepts are essential for incorporating fossils in hypotheses of plant evolution and phylogeny. Plants of the Early Devonian are crucial to reconstructing the initial radiation of tracheophytes, yet few are understood as whole organisms. Methods: This study assembles a whole-plant concept for the Early Devonian lycophyte Sengelia radicans gen...
February 20, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28331288/development-of-venetoclax-for-therapy-of-lymphoid-malignancies
#5
REVIEW
Huayuan Zhu, Alexandru Almasan
B-cell lymphoma-2 (BCL-2) family dysfunction and impairment of apoptosis are common in most B-cell lymphoid malignancies. Venetoclax (Venclexta™, formerly ABT-199, GDC-0199) is a highly selective BCL-2 inhibitor, which mimics its BCL-2 homology 3-domain to induce apoptosis. It was approved for treatment of previously treated chronic lymphocytic leukemia (CLL) patients with 17p deletion early in 2016. It has also been in clinical trials for other B-cell lymphoid malignancies. Unlike the other recently approved targeted agents idelalisib and ibrutinib, so far there has been no relapse reported in some patients...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28329307/eacvi-appropriateness-criteria-for-the-use-of-transthoracic-echocardiography-in-adults-a-report-of-literature-and-current-practice-review
#6
Richard P Steeds, Madalina Garbi, Nuno Cardim, Jaroslaw D Kasprzak, Elif Sade, Petros Nihoyannopoulos, Bogdan Alexandru Popescu, Alexandros Stefanidis, Bernard Cosyns, Mark Monaghan, Svend Aakhus, Thor Edvardsen, Frank Flachskampf, Leonarda Galiuto, George Athanassopoulos, Patrizio Lancellotti
The European Association for Cardiovascular Imaging (EACVI) has outlined the rationale for setting appropriate use criteria (AUC) in cardiovascular (CV) imaging. Transthoracic echocardiography (TTE) is the most common imaging modality in CV disease and is a central tool in diagnosis, follow-up, management planning and intervention. The purpose of AUC is to inform referrers, both to avoid under-use, which may result in incomplete or incorrect diagnosis and treatment, and also over-use, which may delay correct diagnosis, lead to 'treatment cascade', and wastes resources...
February 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28326443/radiological-clinical-and-functional-evaluation-using-the-quick-disabilities-of-the-arm-shoulder-and-hand-questionnaire-of-children-with-medial-epicondyle-fractures-treated-surgically
#7
Federico Canavese, Lorenza Marengo, Alexandru Tiris, Mounira Mansour, Marie Rousset, Antoine Samba, Antonio Andreacchio, Alain Dimeglio
PURPOSE: The main goal of this study was to retrospectively evaluate the clinical, functional and radiographic outcomes of displaced medial epicondyle fractures with or without associated elbow dislocation in children undergoing surgical treatment and to evaluate upper-extremity function with the Quick Disbilities of the Arm, Shoulder and Hand (Quick DASH) questionnaire. The hypothesis was that patients with associated elbow dislocation would have similar functional outcome to patients with displaced fractures with or without intra-articular entrapment of the medial epicondyle...
March 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28326403/effects-of-tranexamic-acid-and-bipolar-sealer-alone-or-in-combination-in-primary-total-knee-arthroplasty-a-prospective-randomized-controlled-trial
#8
Alexandru Seviciu, Irwin Gross, Samreen Fathima, Stephen M Walsh
BACKGROUND: The purpose of this study was to compare 2 blood management interventions, tranexamic acid (TXA) and bipolar sealer system (BSS) used independently or in combination with a control group during primary total knee arthroplasty (TKA). METHODS: A total of 127 TKA patients were enrolled and randomized into 4 groups: Intravenous TXA plus the BSS (N = 29, group 1); TXA only (N = 29, group 2); BSS only (N = 31, group 3); and intravenous normal saline as a control group (N = 32, group 4)...
June 2016: Arthroplast Today
https://www.readbyqxmd.com/read/28321901/a-pneumatic-phantom-for-mimicking-respiration-induced-artifacts-in-spinal-mri
#9
Philippe De Tillieux, Ryan Topfer, Alexandru Foias, Iris Leroux, Imanne El Maâchi, Hugues Leblond, Nikola Stikov, Julien Cohen-Adad
PURPOSE: To design a phantom capable of mimicking human respiration to serve as a testing platform for correction of the static and time-evolving magnetic field distortions typically encountered in MRI of the spinal cord. METHODS: An inflation system to mimic the air variation of the human lungs was constructed. The inflation system was linked to a phantom containing synthetic lungs and an ex vivo human spine. The relationship between air pressure and phantom lung volume was evaluated via imaging experiment...
March 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28303611/improving-left-ventricular-segmentation-in-four-dimensional-flow-mri-using-intramodality-image-registration-for-cardiac-blood-flow-analysis
#10
Vikas Gupta, Mariana Bustamante, Alexandru Fredriksson, Carl-Johan Carlhäll, Tino Ebbers
PURPOSE: Assessment of blood flow in the left ventricle using four-dimensional flow MRI requires accurate left ventricle segmentation that is often hampered by the low contrast between blood and the myocardium. The purpose of this work is to improve left-ventricular segmentation in four-dimensional flow MRI for reliable blood flow analysis. METHOD: The left ventricle segmentations are first obtained using morphological cine-MRI with better in-plane resolution and contrast, and then aligned to four-dimensional flow MRI data...
March 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28298144/enhanced-raman-spectroscopy-via-plasmonic-and-carbonaceous-nanostructures-for-the-detection-diagnosis-and-treatment-of-cancer-part-2-treatment
#11
Emilie Darrigues, Vijayalakshmi Dantuluri, Zeid A Nima, Kieng B Vang, Robert J Griffin, Alexandru R Biris, Anindya Ghosh, Alexandru S Biris
Raman spectroscopy and surface-enhanced Raman scattering (SERS) have the potential to improve the accurate treatment, detection, and monitoring of various diseases, particularly cancer. Over the last decade, technological developments have enhanced Raman spectroscopy's ability to detect, discriminate, and diagnose cancers, both with and without complex nanosystems. This review discusses the recent advances that have made Raman a major tool for tumor resection guidance, for drug delivery targeting and monitoring, and enhancing photodynamic and photothermal therapy with the support of carbon-based and/or noble metal plasmonic nanoparticles...
March 15, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28286784/the-influence-of-metabolic-imbalances-and-oxidative-stress-on-the-outcome-of-critically-ill-polytrauma-patients-a-review
#12
REVIEW
Alexandru Florin Rogobete, Dorel Sandesc, Marius Papurica, Emil Robert Stoicescu, Sonia Elena Popovici, Lavinia Melania Bratu, Corina Vernic, Adriana Mariana Sas, Adrian Tudor Stan, Ovidiu Horea Bedreag
The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28286519/erbb-proteins-as-molecular-target-of-dietary-phytochemicals-in-malignant-diseases
#13
REVIEW
Alexandru Filippi, Oana-Alina Ciolac, Constanța Ganea, Maria-Magdalena Mocanu
ErbB proteins overexpression, in both normal and mutated forms, is associated with invasive forms of cancer prone to metastasis and with stronger antiapoptotic mechanisms and therefore more challenging to treat. Downstream effectors of ErbB receptors mediating these phenotypic traits include MAPK, STAT, and PI3K/AKT/mTOR pathways. Various phytochemical compounds were studied for their large number of biological effects including anticancer activity. Among these compounds, epigallocatechin-3-gallate (EGCG), the main catechin from green tea leaves, and curcumin, component of the curry powder, constituted the object of numerous studies...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28281359/changes-in-skin-microcirculation-during-radiation-therapy-for-breast-cancer
#14
Erik Tesselaar, Anna M Flejmer, Simon Farnebo, Alexandru Dasu
BACKGROUND: The majority of breast cancer patients who receive radiation treatment are affected by acute radiation-induced skin changes. The assessment of these changes is usually done by subjective methods, which complicates the comparison between different treatments or patient groups. This study investigates the feasibility of new robust methods for monitoring skin microcirculation to objectively assess and quantify acute skin reactions during radiation treatment. MATERIAL AND METHODS: Laser Doppler flowmetry, laser speckle contrast imaging, and polarized light spectroscopy imaging were used to measure radiation-induced changes in microvascular perfusion and red blood cell concentration (RBC) in the skin of 15 patients undergoing adjuvant radiation therapy for breast cancer...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28271374/self-stabilizing-ampholytic-starch-excipients-for-sustained-release-of-highly-soluble-drugs-the-case-study-of-metformin
#15
Khalil Sakeer, Pompilia Ispas-Szabo, Mircea Alexandru Mateescu
A new class of starch derivatives carrying cationic and anionic functional groups was developed aiming to provide an alternative for the formulation of highly soluble drugs. The new ampholytic starch derivatives were synthesized in two steps; first the CarboxyMethyl (CM) groups were grafted on starch chains followed by introduction of AminoEthyl (AE) groups. The final product, CarboxyMethyl-AminoEthyl-Starch (CM-AE-St), could be obtained in different degrees of substitution by varying the number of CM and AE groups...
March 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28268594/computational-analysis-of-androgen-receptor-dependent-radiosensitivity-in-prostate-cancer
#16
Mengdi Qian, Alexandru Almasan, Evren Gurkan-Cavusoglu
In this study, we quantitatively analyze the mechanism by which androgen deprivation therapy (ADT) is enhancing radiosensitivity in prostate cancer (PCa) patients. It has been shown in laboratory experiments, as well as in patient data in the literature, that the androgen receptor (AR) reduces the effectiveness of ionizing radiation treatment by enhancing the non-homologous end joining (NHEJ) repair of radiation damage. The suppression of AR by ADT suppresses the activity of NHEJ that leads to radiosensitivity in PCa patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267487/starch-materials-as-biocompatible-supports-and-procedure-for-fast-separation-of-macrophages
#17
Khalil Sakeer, Tatiana Scorza, Hugo Romero, Pompilia Ispas-Szabo, Mircea Alexandru Mateescu
Different starch derivatives were evaluated as supports for attachment and recovery of macrophages (RAW 264.7 line). Gelatinized starch (G-St), acetate starch (Ac-St), carboxymethyl starch and aminoethyl starch were synthesized and characterized by FTIR, (1)H NMR, SEM and static water contact angle. These polymers are filmogenic and may coat well the holder devices used for macrophage adhesion. They also present a susceptibility to mild hydrolysis with alpha-amylase, liberating the adhered macrophages. Cell counts, percentage of dead cells and level of tumor necrosis factor (TNF-α) were used to evaluate the possible interaction between macrophages and starch films...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28266299/appendiceal-diverticulitis-a-case-report
#18
Vlad Denis Constantin, Alexandru Carâp, Anca Nica, Alexandru Smaranda, Bogdan Socea
Appendiceal diverticulitis is a very rare cause for pain in the right iliac fossa. Whether it is simptomatic or discovered randomly during an appendectomy or barium enema, understanding its clinical evolution is important for having a good management. In this report we present the case of a 50 year old female who underwent an open appendectomy during which we discovered appendiceal diverticulitis.
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28266297/surgical-treatment-of-a-rare-reverse-madelung-deformity-in-11-years-female-patient
#19
Alexandru Ulici, Daniel Catalin Florea, Iulia Tevanov, Dan Zaharie, Madalina Carp
Madelung deformity is an abnormality of the distal part of the forearm due to a growth arrest in the distal radial physis creating an increase of the radial tilt angle associated with a dorsal subluxation of the distal ulna in most cases. It is a rare condition which represents only 1.7% of hand deformities being characterized by the presence of an abnormal structure, Vickers ligament, that tethers the distal radius to the lunate bone. Although it is believed to be a congenital disorder, the symptoms are absent till late childhood...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28264641/editorial-nanobiomaterials-for-improving-stem-cell-applications-in-tissue-engineering-and-regenerative-medicine
#20
EDITORIAL
Florin Iordache, Alexandru Mihai Grumezescu
No abstract text is available yet for this article.
2017: Current Stem Cell Research & Therapy
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