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https://www.readbyqxmd.com/read/27906118/social-correlates-of-term-small-for-gestational-age-babies-in-a-russian-arctic-setting
#1
Anna A Usynina, Andrej M Grjibovski, Jon Øyvind Odland, Alexandra Krettek
BACKGROUND: Small for gestational age (SGA) births have been associated with both short- and long-term adverse health outcomes. Although social risk factors for SGA births have been studied earlier, such data are limited from Northern Russia. OBJECTIVE: We assessed maternal social risk factors for term SGA births based on data from the population-based Murmansk County Birth Registry (MCBR). DESIGN: Data on term live-born singleton infants born between 2006 and 2011 in Murmansk County were obtained from the MCBR...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27905966/rapid-assessment-of-disability-in-the-philippines-understanding-prevalence-well-being-and-access-to-the-community-for-people-with-disabilities-to-inform-the-w-dare-project
#2
Manjula Marella, Alexandra Devine, Graeme Ferdinand Armecin, Jerome Zayas, Ma Jesusa Marco, Cathy Vaughan
BACKGROUND: International recognition that people with disabilities were excluded from the Millennium Development Goals has led to better inclusion of people with disabilities in the recently agreed Global Goals for Sustainable Development (SDGs) 2015-2030. Given the current global agenda for disability inclusion, it is crucial to increase the understanding of the situation of people with disabilities in the Philippines. The aim of this study was to estimate the prevalence of disability and compare the well-being and access to the community between people with and without disabilities...
August 2, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905916/study-protocol-a-dose-escalating-phase-2-study-of-oral-lisdexamfetamine-in-adults-with-methamphetamine-dependence
#3
Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker, Nicholas Lintzeris
BACKGROUND: The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for the treatment of methamphetamine dependence. One potential candidate is lisdexamfetamine, a pro-drug for dexamphetamine, which has a longer lasting therapeutic action with a lowered abuse potential. The purpose of this study is to determine the safety of lisdexamfetamine in this population at doses higher than those currently approved for attention deficit hyperactivity disorder or binge eating disorder...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27905243/-always-believe-in-yourself
#4
Layla Haidrani
What is your job? Consultant nurse for acuity out of hours at Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust. I lead the hospital at-night service, which delivers emergency out-of-hours care to 1,100 inpatients. I work clinically as part of this team while managing and developing the service. I am also responsible for the strategic and quality improvement aspects of out-of-hours care.
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27905114/is-sinus-surgery-indicated-for-recurrent-acute-rhinosinusitis
#5
Alexandra Michalowski, Ashutosh Kacker
No abstract text is available yet for this article.
December 1, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27904890/using-signal-amplification-by-reversible-exchange-sabre-to-hyperpolarise-119-sn-and-29-si-nmr-nuclei
#6
Alexandra M Olaru, Alister Burt, Peter J Rayner, Sam J Hart, Adrian C Whitwood, Gary G R Green, Simon B Duckett
The hyperpolarisation of the (119)Sn and (29)Si nuclei in 5-(tributylstannyl)pyrimidine (ASn) and 5-(trimethylsilyl)pyrimidine (BSi) is achieved through their reaction with [IrCl(COD)(IMes)] (1a) or [IrCl(COD)(SIMes)] (1b) and parahydrogen via the SABRE process. 1a exhibits superior activity in both cases. The two inequivalent pyrimidine proton environments of ASn readily yielded signal enhancements totalling ∼2300-fold in its (1)H NMR spectrum at a field strength of 9.4 T, with the corresponding (119)Sn signal being 700 times stronger than normal...
December 1, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27903855/fitz-hugh-curtis-syndrome-consequent-to-a-wound-infection-following-removal-of-a-peritoneal-dialysis-catheter
#7
Tal Zilberman-Daniels, Keren Cohen-Hagai, Yael Einbinder, Alexandra Osadchy, Sydney Benchetrit, Ze'ev Korzets
Fitz-Hugh-Curtis syndrome (FHCS) is a condition characterized by inflammation of the liver capsule (perihepatitis) and adjacent peritoneal surfaces. We report a case of FHCS developing in a peritoneal dialysis (PD) patient in whom catheter removal due to recurrent peritonitis was complicated by post-operative wound infection. To the best of our knowledge, this is the first case description of FHCS in the context of PD.
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27903751/microdose-induced-drug-dna-adducts-as-biomarkers-of-chemotherapy-resistance-in-humans-and-mice
#8
Maike Zimmermann, Si-Si Wang, Hongyong Zhang, Tzu-Yin Lin, Michael Malfatti, Kurt Haack, Ted Ognibene, Hongyuan Yang, Susan Airhart, Kenneth W Turteltaub, George D Cimino, Clifford G Tepper, Alexandra Drakaki, Karim Chamie, Ralph de Vere White, Chong-Xian Pan, Paul T Henderson
We report progress on predicting tumor response to platinum-based chemotherapy with a novel mass spectrometry approach. Fourteen bladder cancer patients were administered one diagnostic microdose each of [14C]carboplatin (1% of the therapeutic dose). Carboplatin-DNA adducts were quantified by accelerator mass spectrometry (AMS) in blood and tumor samples collected within 24 hours, and compared to subsequent chemotherapy response. Patients with the highest adduct levels were responders, but not all responders had high adduct levels...
November 30, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27903529/angiocrine-bmp2-signaling-in-murine-liver-controls-normal-iron-homeostasis
#9
Philipp-Sebastian Koch, Victor Olsavszky, Friederike Ulbrich, Carsten Sticht, Alexandra Demory, Thomas Leibing, Thomas Henzler, Mathias Meyer, Johanna Zierow, Sven Schneider, Katja Breitkopf-Heinlein, Haristi Gaitantzi, Bradley Spencer-Dene, Bernd Arnold, Kay Klapproth, Kai Schledzewski, Sergij Goerdt, Cyrill Géraud
Microvascular endothelial cells (EC) display a high degree of phenotypic and functional heterogeneity among different organs. Organ-specific EC control their tissue microenvironment by angiocrine factors in health and disease. Liver sinusoidal EC (LSEC) are uniquely differentiated to fulfil important organ-specific functions in development, under homeostatic conditions, and in regeneration and liver pathology. Recently, Bmp2 has been identified by us as an organ-specific angiokine derived from LSEC. To study angiocrine Bmp2 signaling in the liver, we conditionally deleted Bmp2 in LSEC using EC subtype-specific Stab2-Cre mice...
November 30, 2016: Blood
https://www.readbyqxmd.com/read/27903244/cryopreservation-of-dermal-fibroblasts-and-keratinocytes-in-hydroxyethyl-starch-based-cryoprotectants
#10
Yahaira Naaldijk, Adiv A Johnson, Annett Friedrich-Stöckigt, Alexandra Stolzing
BACKGROUND: Preservation of human skin fibroblasts and keratinocytes is essential for the creation of skin tissue banks. For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative. The aim of this study was to identify CPAs that minimize toxic effects and allow for the preservation of human fibroblasts and keratinocytes in suspension and in monolayers. RESULTS: We cryopreserved human fibroblasts and keratinocytes with different CPAs and compared them to fresh, unfrozen cells...
December 1, 2016: BMC Biotechnology
https://www.readbyqxmd.com/read/27903135/support-for-relatives-bereaved-by-psychiatric-patient-suicide-national-confidential-inquiry-into-suicide-and-homicide-findings
#11
Alexandra L Pitman, Isabelle M Hunt, Sharon J McDonnell, Louis Appleby, Navneet Kapur
OBJECTIVES: International suicide prevention strategies recommend providing support to families bereaved by suicide. The study objectives were to measure the proportion of cases in which psychiatric professionals contact next of kin after a patient's suicide and to investigate whether specific, potentially stigmatizing patient characteristics influence whether the family is contacted. METHODS: Annual survey data from England and Wales (2003-2012) were used to identify 11,572 suicide cases among psychiatric patients...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27902737/a-comparison-of-the-sensititre-mycotb-plate-the-bactec-mgit-960-and-a-microarray-based-molecular-assay-for-the-detection-of-drug-resistance-in-clinical-mycobacterium-tuberculosis-isolates-in-moscow-russia
#12
Elena Y Nosova, Danila V Zimenkov, Anastasia A Khakhalina, Alexandra I Isakova, Ludmila Y Krylova, Marina V Makarova, Ksenia Y Galkina, Maria A Krasnova, Svetlana G Safonova, Vitaly I Litvinov, Dmitry A Gryadunov, Elena M Bogorodskaya
BACKGROUND: The goal of this study was to compare the consistency of three assays for the determination of the drug resistance of Mycobacterium tuberculosis (MTB) strains with various resistance profiles isolated from the Moscow region. METHODS: A total of 144 MTB clinical isolates with a strong bias toward drug resistance were examined using Bactec MGIT 960, Sensititre MycoTB, and a microarray-based molecular assay TB-TEST to detect substitutions in the rpoB, katG, inhA, ahpC, gyrA, gyrB, rrs, eis, and embB genes that are associated with resistance to rifampin, isoniazid, fluoroquinolones, second-line injectable drugs and ethambutol...
2016: PloS One
https://www.readbyqxmd.com/read/27902669/an-anaphylactoid-reaction-to-rattlesnake-envenomation-in-a-pediatric-patient
#13
Logan Rencher, Joanna Schwartz, Alexandra Wilson
Rattlesnake envenomation causes a spectrum of symptoms and signs, many of which closely resemble an anaphylactic reaction. Development of airway compromise after a snake bite to an extremity is unusual, but has been previously reported. The majority of such reports detail a history of probable sensitization from previous contact with snakes or snake venom. Few reports exist without such previous contact; no reports are of pediatric cases. Here we present a 14-year-old boy with no history of prior snake exposure who presents with an anaphylactoid reaction after a rattlesnake bite...
November 29, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27902286/macrococcus-canis-sp-nov-a-skin-bacterium-associated-with-infections-in-dogs
#14
Stefanie Gobeli Brawand, Kerstin Cotting, Elena Gómez-Sanz, Alexandra Collaud, Andreas Thomann, Isabelle Brodard, Sabrina Rodriguez Campos, Christian Strauss, Vincent Perreten
Gram-stain positive cocci were isolated from miscellaneous sites of the skin of healthy dogs as well as from infection sites in dogs. The closest relative by sequencing of the 16S rRNA was Macrococcus caseolyticus with 99.7% sequence identity, but compared to M. caseolyticus, the novel strains shared only 90.8% to 93.5% DNA identity to cpn60, dnaJ, rpoB, and sodA partial genes, respectively. The two species also exhibited other phenotypic characteristics and the majority displayed a visible haemolysis on sheep blood agar, while M...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27901405/toxische-hautreaktionen-und-unterst%C3%A3-tzungsbedarf-von-krebspatientinnen-im-zuge-einer-egfr-antik%C3%A3-rpertherapie
#15
Martin Matzka, Doreen Stöhr, Alexandra Colditz, Sabine Köck-Hódi, Martina Koller, Hanna Mayer
No abstract text is available yet for this article.
November 30, 2016: Pflege
https://www.readbyqxmd.com/read/27900295/diagnostic-performance-of-volume-and-limited-oblique-mri-of-the-anterior-cruciate-ligament-compared-to-knee-arthroscopy
#16
Paula J Richards, Iain McCall, Alexandra Kraus, Mary Jones, Gayle Maffulli, Stephen Bridgman, Nicola Maffulli
BACKGROUND: Many strategies have been used to improve the visualisation of the ACL including sagittal, coronal oblique sequences, and 3D volume imaging. Nevertheless, the ACL may not always be visualised. METHODS: Two hundred and thirty-one consecutive patients (77 females; 154 males; average age 43.5, range 18 to 82 years; 205 with chronic, 20 acute, and 6 acute on chronic symptoms) underwent knee arthroscopy for mechanical symptoms within a week of MRI. After routine orthogonal sequences, if general MRI radiographers, with over four years experience, were not able to identify the presence of the ACL, then two 3D volume sequences and 2D limited sagittal oblique T1 sequences were performed...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27899632/application-of-sorting-and-next-generation-sequencing-to-study-5-utr-influence-on-translation-efficiency-in-escherichia-coli
#17
Sergey A Evfratov, Ilya A Osterman, Ekaterina S Komarova, Alexandra M Pogorelskaya, Maria P Rubtsova, Timofei S Zatsepin, Tatiana A Semashko, Elena S Kostryukova, Andrey A Mironov, Evgeny Burnaev, Ekaterina Krymova, Mikhail S Gelfand, Vadim M Govorun, Alexey A Bogdanov, Petr V Sergiev, Olga A Dontsova
Yield of protein per translated mRNA may vary by four orders of magnitude. Many studies analyzed the influence of mRNA features on the translation yield. However, a detailed understanding of how mRNA sequence determines its propensity to be translated is still missing. Here, we constructed a set of reporter plasmid libraries encoding CER fluorescent protein preceded by randomized 5' untranslated regions (5'-UTR) and Red fluorescent protein (RFP) used as an internal control. Each library was transformed into Escherchia coli cells, separated by efficiency of CER mRNA translation by a cell sorter and subjected to next generation sequencing...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899624/microscope-in-2017-an-expanding-and-evolving-integrated-resource-for-community-expertise-of-microbial-genomes
#18
David Vallenet, Alexandra Calteau, Stéphane Cruveiller, Mathieu Gachet, Aurélie Lajus, Adrien Josso, Jonathan Mercier, Alexandre Renaux, Johan Rollin, Zoe Rouy, David Roche, Claude Scarpelli, Claudine Médigue
The annotation of genomes from NGS platforms needs to be automated and fully integrated. However, maintaining consistency and accuracy in genome annotation is a challenging problem because millions of protein database entries are not assigned reliable functions. This shortcoming limits the knowledge that can be extracted from genomes and metabolic models. Launched in 2005, the MicroScope platform (http://www.genoscope.cns.fr/agc/microscope) is an integrative resource that supports systematic and efficient revision of microbial genome annotation, data management and comparative analysis...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899529/short-term-effects-of-trans-fatty-acids-from-ruminant-and-industrial-sources-on-surrogate-markers-of-cardiovascular-risk-in-healthy-men-and-women-a-randomized-controlled-double-blind-trial
#19
Thomas Radtke, Alexandra Schmid, Anja Trepp, Frieda Dähler, Michael Coslovsky, Prisca Eser, Matthias Wilhelm, Hugo Saner
OBJECTIVE: The aim of this study was to determine short-term effects of trans fatty acid (TFA) intake from ruminant and industrial sources on surrogate markers of cardiovascular risk in the context of a balanced diet with 30-36% of daily energy from fat. DESIGN: Prospective, randomized, double-blind, parallel-design study. METHODS: In this study, 142 healthy volunteers aged 45 to 69 years were randomly allocated to three different diets: either a diet enriched with 2% of daily energy intake from ruminant TFA (rTFA) or with industrial TFA (iTFA), or a diet without TFA (wTFA), for a duration of four weeks...
November 29, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27898603/an-ultra-high-field-study-of-cerebellar-pathology-in-early-relapsing-remitting-multiple-sclerosis-using-mp2rage
#20
Mário João Fartaria, Kieran OʼBrien, Alexandra Şorega, Guillaume Bonnier, Alexis Roche, Pavel Falkovskiy, Gunnar Krueger, Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera
OBJECTIVES: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). MATERIALS AND METHODS: Twenty early-stage relapsing-remitting MS patients underwent an MP2RAGE acquisition at 7 T magnetic resonance imaging (MRI) (images acquired at 2 different resolutions: 0.58 × 0.58 × 0.58 mm, 7T_0.58, and 0.75 × 0.75 × 0...
November 28, 2016: Investigative Radiology
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