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https://www.readbyqxmd.com/read/29026610/selective-blood-sampling-for-fgf-23-in-tumor-induced-osteomalacia
#1
Hans-Christof Schober, Christian Kneitz, Franziska Fieber, Kathrin Hesse, Henry Schroeder
Tumor-induced osteomalacia (TIO) is caused by the hormone fibroblast growth factor 23 (FGF-23). It is mainly produced in the tissue of mesenchymal tumors. Patients with TIO frequently suffer from a chronic decompensated pain syndrome and/or muscle weakness with postural deformity. Despite the severity of the disease, the diagnosis is frequently established late. In some cases, it takes several years to establish the condition. This case report concerning a 68-year old woman demonstrates the selective blood sampling for FGF-23 as path-breaking diagnostics to confirm the diagnosis of a neuroendocrine tumor...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29024353/exercise-and-physical-activity-for-patients-with-esld-improving-functional-status-and-sarcopenia-while-on-the-transplant-waitlist
#2
REVIEW
Andrés Duarte-Rojo, Astrid Ruiz-Margáin, Aldo J Montaño-Loza, Ricardo Macías-Rodríguez, Arny Ferrando, W Ray Kim
Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis and end-stage liver disease (ESLD). They are the end result of impaired dietary intake, chronic inflammation, altered macro- and micronutrient metabolism, and low physical activity. Frailty is the end result of prolonged sarcopenia and physical deconditioning. It severely affects a patient's functional status, and presents in about 1 in 5 patients on the liver transplant (LT) waitlist. Sarcopenia, poor physical fitness/cardiopulmonary endurance, and frailty are all associated with increased mortality in ESLD...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29022909/mir-216a-inhibits-osteosarcoma-cell-proliferation-invasion-and-metastasis-by-targeting-cdk14
#3
Quanbo Ji, Xiaojie Xu, Ling Li, Stuart B Goodman, Wenzhi Bi, Meng Xu, Yameng Xu, Zhongyi Fan, William J Maloney, Qinong Ye, Yan Wang
Osteosarcoma (OS) has emerged as the most common primary musculoskeletal malignant tumour affecting children and young adults. Cyclin-dependent kinases (CDKs) are closely associated with gene regulation in tumour biology. Accumulating evidence indicates that the aberrant function of CDK14 is involved in a broad spectrum of diseases and is associated with clinical outcomes. MicroRNAs (miRNAs) are crucial epigenetic regulators in the development of OS. However, the essential role of CDK14 and the molecular mechanisms by which miRNAs regulate CDK14 in the oncogenesis and progression of OS have not been fully elucidated...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020996/quality-of-life-profile-of-general-vietnamese-population-using-eq-5d-5l
#4
Long Hoang Nguyen, Bach Xuan Tran, Quynh Ngoc Hoang Le, Tung Thanh Tran, Carl A Latkin
BACKGROUND: Health-related quality of life (HRQOL) is a vital benchmark to assess the effects of health interventions and policies. Measuring HRQOL of the general population is essential to establish a reference for health outcomes evaluations. However, evidence on HRQOL of general populations in low and middle income countries is very limited. This study aimed to measure HRQOL of the Vietnamese population by using the EuroQol-5 dimensions-5 levels (EQ-5D-5L) instrument and determine its associated factors...
October 11, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29020961/hazardous-waste-and-health-impact-a-systematic-review-of-the-scientific-literature
#5
REVIEW
L Fazzo, F Minichilli, M Santoro, A Ceccarini, M Della Seta, F Bianchi, P Comba, M Martuzzi
Waste is part of the agenda of the European Environment and Health Process and included among the topics of the Sixth Ministerial Conference on Environment and Health. Disposal and management of hazardous waste are worldwide challenges. We performed a systematic review to evaluate the evidence of the health impact of hazardous waste exposure, applying transparent and a priori defined methods. The following five steps, based on pre-defined systematic criteria, were applied. 1. Specify the research question, in terms of "Population-Exposure-Comparators-Outcomes" (PECO)...
October 11, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29018641/prevalence-and-determinants-of-frozen-shoulder-in-patients-with-diabetes-a-single-center-experience-from-pakistan
#6
Faisal Inayat, Nouman Safdar Ali, Haroon Shahid, Fariha Younus
Introduction Frozen shoulder (FS) or adhesive capsulitis is a constellation of symptoms like pain, stiffness, and/or functional deficit at the glenohumeral joint. It is one of the musculoskeletal complications in patients with diabetes that can be particularly debilitating. The aim of this study is to estimate the prevalence of FS and to compare the determinants of this disease in a population with diabetes from Lahore, Pakistan. Materials and Methods We carried out this cross-sectional study on a systematically randomized sample of 80 patients with diabetes...
August 6, 2017: Curēus
https://www.readbyqxmd.com/read/29018568/person-focused-care-for-young-people-with-rheumatic-and-musculoskeletal-diseases-young-rheumatologists-and-eular-young-pare-perspectives
#7
Alessia Alunno, Paul Studenic, Elena Nikiphorou, Petra Balážová, Linda van Nieuwkoop, Sofia Ramiro, Francesco Carubbi, Christophe Richez, Nele Caeyers, Laure Gossec, Marios Kouloumas
In recent years, the evolution of healthcare challenged the management of people with rheumatic and musculoskeletal diseases (RMDs). From disease-centred care to person-focused care, a holistic approach along with patient empowerment about their disease, improved the physician-patient relationship and allowed to achieve better outcomes with lower healthcare costs. Nevertheless, RMDs may occur from childhood to the old age and to date very few studies have addressed the needs and priorities of young people with RMDs...
2017: RMD Open
https://www.readbyqxmd.com/read/29017892/muscle-functions-and-bone-strength-are-impaired-in-adolescents-with-type-1-diabetes
#8
Klara Maratova, Ondrej Soucek, Jana Matyskova, Zdenek Hlavka, Lenka Petruzelkova, Barbora Obermannova, Stepanka Pruhova, Stanislava Kolouskova, Zdenek Sumnik
BACKGROUND: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. METHODS: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16...
October 7, 2017: Bone
https://www.readbyqxmd.com/read/28994017/comparison-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-with-gallium-67-scintigraphy-in-the-initial-clinical-staging-of-diffuse-large-b-cell-lymphoma
#9
Masatoshi Sakurai, Takaaki Toyama, Taku Kikuchi, Jun Kato, Takayuki Shimizu, Yuya Koda, Daiki Karigane, Yusuke Yamane, Ryohei Abe, Rie Yamazaki, Tomonori Nakazato, Tadaki Nakahara, Masahiro Jinzaki, Shinichiro Okamoto, Takehiko Mori
Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been recommended as a complementary tool for the staging of various malignancies, including malignant lymphoma. PET findings often shift patients to higher stages and may affect treatment outcomes. In this study, we retrospectively compared staging and treatment outcomes of newly diagnosed diffuse large B-cell lymphoma (DLBCL) assessed by PET (n = 153) or gallium-67 scintigraphy (Ga) (n = 95). In total, Ga upstaged two (2.1%) of 95 patients, whereas PET upstaged 13 (8...
October 9, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28992768/peripheral-artery-disease-what-the-orthopaedic-physical-therapist-needs-to-know
#10
Matthew K Walsworth, Rob de Bie, Stephen Figoni, Jessica O'Connell
Synopsis Claudication from peripheral artery disease (PAD) may mimic or coexist with musculoskeletal conditions and represents an important diagnostic consideration in patients over 50. Physical therapists are optimally positioned to recognize this condition by incorporating a vascular history and physical examination in appropriately selected patients. Recognition of PAD is important both from the standpoint of addressing the ischemic risk to the limb and because PAD associated with high cerebrovascular and cardiovascular risk...
October 9, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28992399/a-rapid-evaluation-of-activity-in-lupus-lfa-real-%C3%A2-correlates-with-more-complex-disease-activity-instruments-whether-evaluated-by-clinical-investigators-or-real-world-clinicians
#11
Anca D Askanase, Samantha C Nguyen, Karen Costenbader, S Sam Lim, Diane Kamen, Cynthia Aranow, Jennifer Grossman, Teja M Kapoor, DeAnna Baker-Frost, Teresa Aberle, Aikaterini Thanou-Stavraki, Leslie M Hanrahan, Mimi Kim, Joan T Merrill
Lupus disease measures such as the SLE Disease Activity Index (SLEDAI) and the British Isles Lupus Assessment Group (BILAG) Index are challenging to interpret. The Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) is intended to provide an efficient application of anchored visual analogue scores, each representing the individual severity of active symptoms, with the sum of individual scores deriving an overall disease activity assessment. OBJECTIVES: To compare the performance of LFA-REAL to SLE disease activity assessments and compare scores between trained lupus clinical investigators and clinicians...
October 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28991920/health-related-impact-on-quality-of-life-and-coping-strategies-for-chikungunya-a-qualitative-study-in-cura%C3%A3-ao
#12
Jelte Elsinga, Martin P Grobusch, Adriana Tami, Izzy Gerstenbluth, Ajay Bailey
INTRODUCTION: Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our knowledge, this study is the first qualitative examination of HRQoL and coping strategies of chikungunya-infected individuals. METHODS: Qualitative research methods consisted of 20 in-depth interviews and seven Focus Group Discussions (FGDs), n = 50...
October 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28988692/the-survey-on-cellular-and-tissue-engineered-therapies-in-europe-and-neighboring-eurasian-countries-in-2014-and-2015
#13
Hilary Ireland, Max H P Gay, Helen Baldomero, Barbara De Angelis, Hossein Baharvand, Mark W Lowdell, Jakob Passweg, Ivan Martin
BACKGROUND AIMS: With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. METHODS: In 2015 [respectively 2014], 205 [276] teams from 32 countries responded to the cellular and tissue-engineered therapy survey; 178 [126] teams reported treating 3686 [2665] patients...
October 4, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28988517/developing-and-testing-a-consensus-based-core-set-of-outcome-measures-for-rehabilitation-in-musculoskeletal-diseases
#14
M Klokkerud, H Dagfinrud, T Uhlig, T N Dager, K-A Furunes, Å Klokkeide, M Larsen, S Nygård, S Nylenna, L Øie, I Kjeken
OBJECTIVES: Rehabilitation is important for people with musculoskeletal diseases (MSDs), and evaluating the effect of rehabilitation on both an individual and group level is advocated. A consensus concerning use of outcome measures will improve collaboration between healthcare providers, and increase the possibility of conducting meta-analyses in future research. The aim of this study was to develop a consensus-based core set of outcome measures for rehabilitation in MSDs, and to test the feasibility and responsiveness of the set...
October 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28988266/effect-of-arm-position-on-width-of-the-subacromial-space-of-upper-string-musicians
#15
Elliot V Smithson, Elizabeth Reed Smith, Gary McIlvain, Mark K Timmons
OBJECTIVE: Musicians often end their musical career due to musculoskeletal injury. A leading source of shoulder pain in upper string musicians is rotator cuff disease (RCD). Multiple factors contribute to its development. Compressive overload of the soft tissues of the subacromial space resulting from a decrease in the width of the subacromial space has been identified as an extrinsic factor contributing to RCD development. The purpose of this study was to characterize the width of the subacromial space by measuring acromial-humeral distance (AHD) of upper string musicians, while their arms are in standard playing positions...
September 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28988152/acute-effects-of-static-stretching-on-the-shear-elastic-moduli-of-the-medial-and-lateral-gastrocnemius-muscles-in-young-and-elderly-women
#16
Masatoshi Nakamura, Tome Ikezoe, Satoru Nishishita, Jun Umehara, Misaka Kimura, Noriaki Ichihashi
PURPOSE: Generally, static stretching (SS) is the recommended intervention for a decline in the range of motion among elderly adults. However, no study has investigated the acute effects of SS on the shear elastic modulus in elderly people. The aims of the present study were to investigate the acute effects of SS on the shear elastic moduli of the medial and lateral gastrocnemius muscles and to examine the differences in these acute effects between young and elderly women. METHODS: This study included 15 healthy young women (age: 23...
September 25, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28987469/prevalence-of-sarcopenia-and-its-association-with-activities-of-daily-living-and-dysphagia-in-convalescent-rehabilitation-ward-inpatients
#17
Yoshihiro Yoshimura, Hidetaka Wakabayashi, Takahiro Bise, Maiko Tanoue
BACKGROUND: The purpose of this study was to investigate the prevalence of sarcopenia following stroke, musculoskeletal disease, or hospital-associated deconditioning in convalescent rehabilitation ward inpatients. The association between the activities of daily living (ADLs), dysphagia, and sarcopenia was also assessed. METHODS: A cross-sectional study was performed in consecutive patients admitted to convalescent rehabilitation wards. Sarcopenia was defined as a loss of skeletal muscle mass and decreased muscle strength...
September 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28986811/analysis-of-herbal-medicine-prescriptions-for-patients-in-an-academic-korean-medical-hospital-a-cross-sectional-study-of-electronic-medical-records-2010-2013
#18
Byung-Wook Lee, Hyeon-Yeop Lee, Kwang-Ho Heo, Hyun-Woo Cho, Man-Suk Hwang, In Heo, Byung-Cheul Shin, Eui-Hyoung Hwang
OBJECTIVE: To obtain fundamental information for the standardization of herbal medicine in Korea. METHODS: We analyzed the herbal medicine prescription data of patients at the Pusan National University Korean Medicine Hospital from March 2010 to February 2013. We used the Dongui-Bogam (Dong Yi Bao Jian) to classify prescribed herbal medicines. RESULTS: The study revealed that the most frequently prescribed herbal medicine was 'Liuwei Dihuang Pill (LWDHP, )' which was used for invigorating 'Shen (Kidndy)-yin'...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28983679/safety-of-omitting-routine-bleeding-tests-prior-to-image-guided-musculoskeletal-core-needle-biopsy
#19
Yuri Shif, Justin W Kung, Colm J McMahon, Jennifer Ni Mhuircheartaigh, Yu Ching Lin, Megan E Anderson, Jim S Wu
PURPOSE: To evaluate the safety of withholding preprocedure international normalized ratio (INR) and platelet testing in patients undergoing musculoskeletal (MSK) core needle biopsy (CNB). MATERIAL AND METHODS: Initially, a retrospective review of 1,162 consecutive patients undergoing MSK CNB with preprocedural INR and platelet testing was performed. Clinical (age, gender, bleeding disorder, liver disease, anticoagulation use, INR > 2, platelet count <50,000/ul) and biopsy factors (imaging modality, lesion type, biopsy needle gauge, number biopsy samples) were tested for association with bleeding complications...
October 6, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28980897/comparison-of-patients-with-familial-mediterranean-fever-accompanied-with-sacroiliitis-and-patients-with-juvenile-spondyloarthropathy
#20
Hafize Emine Sönmez, Ezgi Deniz Batu, Selcan Demir, Yelda Bilginer, Seza Özen
OBJECTIVES: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease manifesting with self-limited recurrent febrile attacks and polyserositis. Acute recurrent monoarthritis is the most common form of musculoskeletal involvement in FMF; however, up to 5% of FMF patients may develop chronic joint diseases including sacroiliitis. It is difficult to distinguish whether sacroiliitis is a musculoskeletal finding of FMF or whether this is the coexistence of two diseases, FMF and SpA...
September 26, 2017: Clinical and Experimental Rheumatology
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