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musculoskeletical diseases

Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
Sabrina Gmuca, Rui Xiao, Pamela F Weiss, David D Sherry, Andrea M Knight, Jeffrey S Gerber
Objective: Thirty percent of adults with fibromyalgia receive an opioid, but the prevalence of opioid prescribing in pediatric chronic musculoskeletal pain is unknown. The aims of this study were to determine the prevalence of and factors associated with opioid exposure and polypharmacy among children with chronic musculoskeletal pain. Methods: In this retrospective cohort study using health care claims data from 2000 to 2013, the index date was the first ICD-9 code 729...
June 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Monty A Silverdale, Christopher Kobylecki, Lewis Kass-Iliyya, Pablo Martinez-Martin, Michael Lawton, Sarah Cotterill, K Ray Chaudhuri, Huw Morris, Fahd Baig, Nigel Williams, Leon Hubbard, Michele T Hu, Donald G Grosset
INTRODUCTION: The causes of pain in early/moderate Parkinson's disease (PD) are not well understood. Although peripheral factors such as rigidity, reduced joint movements and poor posture may contribute towards the development of pain, central mechanisms including altered nociceptive processing may also be involved. METHODS: We performed a large clinical study to investigate potential factors contributing towards pain in early/moderate PD. We recruited 1957 PD participants who had detailed assessments of pain, motor and non-motor symptoms...
June 6, 2018: Parkinsonism & related Disorders
Trevor J Royce, Muhammad M Qureshi, Minh Tam Truong
BACKGROUND: The changing use of radiation as a first-line cancer therapy in the United States is poorly characterized. This study aims to report radiotherapy utilization and fractionation patterns during the first course of cancer treatment. METHODS: We extracted all solid tumor cases from 2004 to 2014 in the National Cancer Data Base, which captures only the first course of treatment. Patients were subcategorized by disease site: breast, central nervous system (CNS), gastrointestinal, genitourinary, gynecologic, head and neck (HN), musculoskeletal, skin, or thoracic...
June 11, 2018: Journal of the American College of Radiology: JACR
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Rana Charafeddine, Lydia Gisle, Patrick Deboosere, Herman Van Oyen
Background: Smoking is the leading cause of premature mortality and morbidity. This study aimed at assessing the impact of smoking on life expectancy (LE) and LE with (LED) and without disability (DFLE). We further estimated the contribution of disability and mortality and their causes to differences in LED and DFLE by smoking. Methods: Data on disability, chronic conditions, and smoking from 17 148 participants of the 1997, 2001, 2004 Belgian Health Interview Surveys were used to estimate causes of disability using the attribution method...
June 12, 2018: European Journal of Public Health
Neelam Khetpal, Sameen Khalid, Ranjeet Kumar, Manuel F Betancourt, Akash Khetpal, Christopher Wasyliw, Seema Patel
Musculoskeletal tuberculosis accounts for 1%-3% of all cases of tuberculosis (TB) worldwide with elbow involvement being even less common. The most cases of tuberculous arthritis occur in patients born in and emigrated from endemic regions, especially in patients who are co-infected with human immunodeficiency virus (HIV). We present a rare case of tuberculous septic arthritis of the elbow joint in a 78-year-old African-American female from the United States, with no history of travel abroad. Her presenting symptoms included pain, swelling, and decreased range of motion of the right elbow for six months...
April 11, 2018: Curēus
Xin Li, Xuan Zhou, Howe Liu, Nan Chen, Juping Liang, Xiaoyan Yang, Guoyun Zhao, Yanping Song, Qing Du
Elastic therapeutic taping (ET) has been widely used for a series of musculoskeletal diseases in recent years. However, there remains clinical uncertainty over its efficiency for knee osteoarthritis (knee OA) management. To assess the effects of ET on patients with knee OA, we investigated outcomes including self-reported pain, knee flexibility, knee-related health status, adverse events, muscle strength, and proprioceptive sensibility. Ten databases including PubMed, EMBASE, Cochrane Library, CINAHL, Web of Science, PEDro, Research Gate, CNKI, CBM, and Wanfang were systematically searched...
April 2018: Aging and Disease
Sandra Laternser, Hansjoerg Keller, Olivier Leupin, Martin Rausch, Ursula Graf-Hausner, Markus Rimann
Two-dimensional (2D) cell cultures do not reflect the in vivo situation, and thus it is important to develop predictive three-dimensional (3D) in vitro models with enhanced reliability and robustness for drug screening applications. Treatments against muscle-related diseases are becoming more prominent due to the growth of the aging population worldwide. In this study, we describe a novel drug screening platform with automated production of 3D musculoskeletal-tendon-like tissues. With 3D bioprinting, alternating layers of photo-polymerized gelatin-methacryloyl-based bioink and cell suspension tissue models were produced in a dumbbell shape onto novel postholder cell culture inserts in 24-well plates...
June 1, 2018: SLAS Technology
Daniel G Whitney, Mark D Peterson, Maureen J Devlin, Michelle S Caird, Edward A Hurvitz, Christopher M Modlesky
Individuals with cerebral palsy (CP) exhibit neuromuscular complications and low physical activity levels. Adults with CP exhibit a high prevalence of chronic diseases, which is associated with musculoskeletal deficits. Children with CP have poor musculoskeletal accretion accompanied by excess bone marrow fat, which may lead to weaker bones. Mechanistic studies to determine the role of bone marrow fat on skeletal growth and maintenance, and how it relates to systemic energy metabolism among individuals with CP, are lacking...
June 12, 2018: American Journal of Physical Medicine & Rehabilitation
Caitlin Grant, Bridget Williams, Tim Driscoll
Background: This study aimed to provide a detailed insight into the nature of the content published in the International Journal of Epidemiology (IJE) over its history. Methods: This study reviewed five complete volumes of the IJE at 10-year intervals (1976, 1986, 1996, 2006 and 2016). Information was extracted for 628 articles considered to be most representative of the content of the IJE, with detailed information analysed for 435 articles identified as original research articles...
June 8, 2018: International Journal of Epidemiology
Erika Marroquín-Fabián, Natllely Ruiz, Jorge Mena-Zúñiga, Luis Felipe Flores-Suárez
OBJECTIVES: Granulomatosis with polyangiitis-a primary systemic vasculitis-most frequent manifestations are respiratory. Airway disease can present with stenosis, and although subglottic stenosis (SGS) is well described, narrowing distal to the glottis has been more recently the focus of reporting. Our objectives, therefore, are to describe the frequency, characteristics, and treatment of tracheobronchial stenoses (TBS) in granulomatosis with polyangiitis (GPA) at our institution, a national referral center for respiratory diseases...
May 16, 2018: Seminars in Arthritis and Rheumatism
Enrique Cuevas-Orta, Ángel Javier Pedro-Martínez, Cristina Ramírez-Rodríguez, Carlos Abud-Mendoza
BACKGROUND: Medical meetings are a tool to help physicians advance and update their medical knowledge. Their quality is the responsibility of colleges and institutions. OBJECTIVE: To assess and compare the academic level of four different annual rheumatology meetings. MATERIAL AND METHODS: As a source of information, we used the abstracts published in the supplements of the journal Reumatología Clínica, SE1 Vol. 12, issued in February 2016, SE 1 Vol...
June 8, 2018: Reumatología Clinica
Georgios Filippou, Garifallia Sakellariou, Carlo Alberto Scirè, Greta Carrara, Federica Rumi, Emanuela Bellis, Antonella Adinolfi, Alberto Batticciotto, Alessandra Bortoluzzi, Giovanni Cagnotto, Marta Caprioli, Marco Canzoni, Francesco Paolo Cavatorta, Orazio De Lucia, Valentina Di Sabatino, Antonella Draghessi, Ilaria Farina, Maria Cristina Focherini, Alessandra Gabba, Marwin Gutierrez, Luca Idolazzi, Filippo Luccioli, Pierluigi Macchioni, Marco Sergio Massarotti, Claudio Mastaglio, Luana Menza, Maurizio Muratore, Simone Parisi, Valentina Picerno, Matteo Piga, Roberta Ramonda, Bernd Raffeiner, Daniela Rossi, Silvia Rossi, Paola Rossini, Crescenzio Scioscia, Carlo Venditti, Alessandro Volpe, Annamaria Iagnocco
OBJECTIVE: To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS: A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres participated, enrolling consecutive patients with RA in clinical remission. All patients underwent complete clinical assessment (demographic data, disease characteristics, laboratory exams, clinical assessment of 28 joints and patient/physician-reported outcomes) and Power Doppler (PD) US evaluation of wrist, metacarpalphalangeal joints, proximal interphalangeal joints and synovial tendons of the hands and wrists at enrolment, 6 and 12 months...
June 9, 2018: Annals of the Rheumatic Diseases
D Bellavia, L Raimondi, V Costa, A De Luca, V Carina, M Maglio, M Fini, R Alessandro, G Giavaresi
BACKGROUND: Exosomes are nanovesicles actively secreted by potentially all cell types, including tumour cells, with the primary role of extracellular systemic communication mediators, both at autocrine and paracrine levels, at short and long distances. Recently, different studies have used exosomes as a delivery system for a plethora of different molecules, such as drugs, microRNAs and proteins. This has been made possible thanks to the simplicity in exosomes engineering, their great stability and versatility for applications in oncology as well as in regenerative medicine...
June 6, 2018: Biochimica et Biophysica Acta
Marjolein P Baar, Eusebio Perdiguero, Pura Muñoz-Cánoves, Peter Lj de Keizer
Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often used to assess whether the predicted benefits of a therapy outweigh the risks for older patients. Senescent cells form as a consequence of unresolved molecular damage and persistently secrete molecules that can impair tissue function. Recent evidence shows senescent cells can chronically interfere with stem cell function and drive aging of the musculoskeletal system. In addition, targeted apoptosis of senescent cells can restore tissue homeostasis in aged animals...
June 5, 2018: Current Opinion in Pharmacology
Radosław Jeleniewicz, Dorota Suszek, Maria Majdan
OBJECTIVE: Introduction: Musculoskeletal symptoms are not characteristic for granulomatosis with polyangiitis (GPA) patients. However, they could be present in two-thirds of patients at the onset of the disease and may provoke diagnostic difficulties. The aim: To assess retrospectively musculoskeletal manifestations in a group of GPA patients. PATIENTS AND METHODS: Material and methods: The analyzed group consisted of 44 patients with GPA (27M, 17F) aged 46.7 years (16-75) and treated at the Department of Rheumatology and Connective Tissue Diseases in Lublin between 2010-2016...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Véronique Freire, Thomas P Moser, Marianne Lepage-Saucier
Musculoskeletal calcifications are frequent on radiographs and sometimes problematic. The goal of this article is to help radiologists to make the correct diagnosis when faced with an extraosseous musculoskeletal calcification. One should first differentiate a calcification from an ossification or a foreign body and then locate the calcification correctly. Each location has a specific short differential diagnosis, with minimal further investigation necessary. Intra-tendon calcifications are most frequently associated with hydroxyapatite deposition disease (HADD)...
June 7, 2018: Insights Into Imaging
Lisiane Pruinelli, György J Simon, Karen A Monsen, Timothy Pruett, Cynthia R Gross, David M Radosevich, Bonnie L Westra
BACKGROUND: Liver transplants account for a high number of procedures with major investments from all stakeholders involved; however, limited studies address liver transplant population heterogeneity pretransplant predictive of posttransplant survival. OBJECTIVE: The aim of the study was to identify novel and meaningful patient clusters predictive of mortality that explains the heterogeneity of liver transplant population, taking a holistic approach. METHODS: A retrospective cohort study of 344 adult patients who underwent liver transplantation between 2008 through 2014...
June 5, 2018: Nursing Research
A J Mighell, C Freeman, P A Atkin, J H Bennett, J A G Buchanan, M Carrozzo, A J Crighton, M P Escudier, J Gibson, C M Healy, A M Hegarty, J S Kerr, C E McCreary, M N Pemberton, B Rajlawat, A Richards, K Staines, E D Theaker, A Willis
INTRODUCTION: Oral Medicine focuses on care for patients with chronic, recurrent and medically related disorders of the orofacial region that are distinct from diseases of the periodontal and tooth tissues, with an emphasis on non-surgical management. At present, there are no shared outcomes for Oral Medicine to define the standards to be achieved before new graduates become registered dentists engaged with ongoing professional development. CURRICULUM: We present a consensus undergraduate curriculum in Oral Medicine agreed by representatives from 18 Dental Schools in the United Kingdom and Republic of Ireland...
June 6, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
Wolfgang Kemmler, Anja Weissenfels, Sebastian Willert, Mahdieh Shojaa, Simon von Stengel, Andre Filipovic, Heinz Kleinöder, Joshua Berger, Michael Fröhlich
Exercise positively affects most risk factors, diseases and disabling conditions of middle to advanced age, however the majority of middle-aged to older people fall short of the exercise doses recommended for positively affecting cardio-metabolic, musculoskeletal and neurophysiological fitness or disabling conditions. Whole-Body Electromyostimulation (WB-EMS) may be a promising exercise technology for people unable or unmotivated to exercise conventionally. However, until recently there has been a dearth of evidence with respect to WB-EMS-induced effects on health-related outcomes...
2018: Frontiers in Physiology
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