Katie A O'Brien, Wanjun Gu, Julie A Houck, Lorenz M W Holzner, Hong Wa Yung, Jenna L Armstrong, Alice P Sowton, Ruby Baxter, Paula M Darwin, Lilian Toledo-Jaldin, Litzi Lazo-Vega, Any Moreno-Aramayo, Valquiria Miranda-Garrido, Jonathan A Shortt, Christopher J Matarazzo, Hussna Yasini, Graham J Burton, Lorna G Moore, Tatum S Simonson, Andrew J Murray, Colleen Glyde Julian
BACKGROUND: The chronic hypoxia of high-altitude residence poses challenges for tissue oxygen supply and metabolism. Exposure to high altitude during pregnancy increases the incidence of hypertensive disorders of pregnancy and fetal growth restriction and alters placental metabolism. High-altitude ancestry protects against altitude-associated fetal growth restriction, indicating hypoxia tolerance that is genetic in nature. Yet, not all babies are protected and placental pathologies associated with fetal growth restriction occur in some Andean highlanders...
November 29, 2023: Hypertension