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https://www.readbyqxmd.com/read/28917782/studies-on-the-retention-mechanism-of-solutes-in-hydrophilic-interaction-chromatography-using-stoichiometric-displacement-theory-i-the-linear-relationship-of-lgk-vs-lg-h2o
#1
Fei Wang, Fan Yang, Yang Tian, Jiawei Liu, Jiwei Shen, Quan Bai
A stoichiometric displacement model for retention (SDM-R) of small solutes and proteins based on hydrophilic interaction chromatography (HILIC) was presented. A linear equation that related the logarithm of the capacity factor of the solute to the logarithm of the concentration of water in the mobile phase was derived. The stoichiometric displacement parameters, Z (the number of water molecules required to displace a solute from ligands) and lgI (containing a number of constants that relate to the affinity of solute to the ligands) could be obtained from the slope and the intercept of the linear plots of lgk' vs...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28899766/health-relevance-of-the-modification-of-low-grade-inflammation-in-ageing-inflammageing-and-the-role-of-nutrition
#2
REVIEW
Philip C Calder, Nabil Bosco, Raphaëlle Bourdet-Sicard, Lucile Capuron, Nathalie Delzenne, Joel Doré, Claudio Franceschi, Markus J Lehtinen, Tobias Recker, Stefano Salvioli, Francesco Visioli
Ageing of the global population has become a public health concern with an important socio-economic dimension. Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed "inflammageing". The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions...
September 9, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28856799/complexity-analysis-of-cortical-surface-detects-changes-in-future-alzheimer-s-disease-converters
#3
Juan Ruiz de Miras, Víctor Costumero, Vicente Belloch, Joaquín Escudero, César Ávila, Jorge Sepulcre
Alzheimer's disease (AD) is a neurological disorder that creates neurodegenerative changes at several structural and functional levels in human brain tissue. The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of the human brain. In this study, we investigate spherical harmonic-based FD (SHFD), thickness, and local gyrification index (LGI) to assess whether they identify cortical surface abnormalities toward the conversion to AD. We study 33 AD patients, 122 mild cognitive impairment (MCI) patients (50 MCI converters and 29 MCI nonconverters), and 32 healthy controls (HC)...
August 30, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28728046/advanced-morphological-neuroimaging-study-in-lateral-temporal-lobe-epilepsy-a-multicentric-study
#4
Roberta Vasta, Alessia Sarica, Francesca Bisulli, Giancarlo Di Gennaro, Alfredo D'Aniello, Jacopo C Difrancesco, Laura Canafoglia, Marina Casazza, Silvana Franceschetti, Carlotta Stipa, Paolo Tinuper, Laura Mumoli, Antonio Gambardella, Angelo Labate
Lateral temporal lobe epilepsy (lTLE) is a rare condition characterized by auditory auras or receptive aphasia, negative MRI, and relatively benign evolution. With the low number of cases in the world, our objective was to analyze a cohort of sporadic cases with lTLE (slTLE), in order to investigate possible cerebral morphological alterations. Forty patients with lTLE (34.93±12.08years of age) and 38 healthy controls (CTRL, 34.55±9.08years of age) were enrolled from four tertiary Italian epilepsy centers, which provided brain MRI T1-weighted images following a standard protocol for patients with epilepsy...
September 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28727783/the-impact-of-local-government-investment-on-the-carbon-emissions-reduction-effect-an-empirical-analysis-of-panel-data-from-30-provinces-and-municipalities-in-china
#5
Lingyun He, Fang Yin, Zhangqi Zhong, Zhihua Ding
Among studies of the factors that influence carbon emissions and related regulations, economic aggregates, industrial structures, energy structures, population levels, and energy prices have been extensively explored, whereas studies from the perspective of fiscal leverage, particularly of local government investment (LGI), are rare. Of the limited number of studies on the effect of LGI on carbon emissions, most focus on its direct effect. Few studies consider regulatory effects, and there is a lack of emphasis on local areas...
2017: PloS One
https://www.readbyqxmd.com/read/28709499/increased-occipital-gyrification-and-development-of-psychotic-disorders-in-individuals-with-an-at-risk-mental-state-a%C3%A2-multicenter-study
#6
Daiki Sasabayashi, Yoichiro Takayanagi, Tsutomu Takahashi, Shinsuke Koike, Hidenori Yamasue, Naoyuki Katagiri, Atsushi Sakuma, Chika Obara, Mihoko Nakamura, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, Kiyoto Kasai, Michio Suzuki
BACKGROUND: Anomalies of brain gyrification have been reported in schizophrenia, possibly reflecting its neurodevelopmental pathology. However, it remains elusive whether individuals at risk for psychotic disorders exhibit deviated gyrification patterns, and whether such findings, if present, are predictive of transition to psychotic disorders. METHODS: This multicenter magnetic resonance imaging study investigated brain gyrification and its relationship to later transition to psychotic disorders in a large sample of at-risk mental state (ARMS) individuals...
July 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28694840/hepatic-adipocyte-enteric-and-pancreatic-hormones-response-to-dietary-macronutrient-composition-and-relationship-with-metabolism
#7
Bridget M Hron, Cara B Ebbeling, Henry A Feldman, David S Ludwig
BACKGROUND: We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS: Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycemic index (LGI) and very low carbohydrate (VLC)] in random order, each for 4 weeks. At baseline and at the end of each treatment period, fasting samples for fibroblast growth factor (FGF)-21, heme-oxygenase-1 (HO-1), chemerin, irisin, secreted frizzle-related protein (SFRP-4), total bile acids, ghrelin, gastrin inhibitory peptide (GIP), peptide-Y, and amylin; hepatic and peripheral IS; and EE were obtained...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28686199/postprandial-effects-of-breakfast-glycemic-index-on-vascular-function-among-young-healthy-adults-a-crossover-clinical-trial
#8
Natalia Sanchez-Aguadero, Maria C Patino-Alonso, Sara Mora-Simon, Manuel A Gomez-Marcos, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado, Jose I Recio-Rodriguez, Luis Garcia-Ortiz
This study aimed to evaluate the postprandial effects of high and low glycemic index (GI) breakfasts on vascular function. It was a crossover trial that included 40 young healthy adults (50% women), aged 20-40 years, who were recruited at primary care settings. They consumed three experimental breakfasts in randomized order, each one separated by a 1-week washout period: (1) control conditions (only water); (2) low GI (LGI) breakfast (29.4 GI and 1489 KJ energy); and (3) high GI (HGI) breakfast (64.0 GI and 1318 KJ energy)...
July 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28676299/adolescent-maturation-of-the-relationship-between-cortical-gyrification-and-cognitive-ability
#9
Yu Sun Chung, Christopher J Hyatt, Michael C Stevens
There are changes to the degree of cortical folding from gestation through adolescence into young adulthood. Recent evidence suggests that degree of cortical folding is linked to individual differences in general cognitive ability in healthy adults. However, it is not yet known whether age-related cortical folding changes are related to maturation of specific cognitive abilities in adolescence. To address this, we examined the relationship between frontoparietal cortical folding as measured by a Freesurfer-derived local gyrification index (lGI) and performance on subtests from the Wechsler Abbreviated Scale of Intelligence and scores from Conner's Continuous Performance Test-II in 241 healthy adolescents (ages 12-25 years)...
July 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28640233/metabolic-effects-of-high-glycaemic-index-diets-a-systematic-review-and-meta-analysis-of-feeding-studies-in-mice-and-rats
#10
REVIEW
Grace J Campbell, Alistair M Senior, Kim S Bell-Anderson
Low glycaemic index (LGI) diets are often reported to benefit metabolic health, but the mechanism(s) responsible are not clear. This review aimed to systematically identify studies investigating metabolic effects of high glycaemic index (HGI) versus LGI diets in mice and rats. A meta-analysis was conducted to calculate an overall effect size, Hedge's standardised mean differences (hereafter d), for each trait, with moderator variables considered in subsequent meta-regressions. Across 30 articles, a HGI diet increased five of the seven traits examined: body weight (d = 0...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28579810/leucine-rich-glioma-inactivated-3-integrative-analyses-support-its-prognostic-role-in-glioma
#11
Nyoun Soo Kwon, Dong-Seok Kim, Hye-Young Yun
BACKGROUND: Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM: This study aimed to analyze differentially expressed genes in glioma tissues and glioma cohort data to investigate the prognostic role of LGI3 and its receptors...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28534931/leucine-rich-glioma-inactivated-3-integrative-analyses-support-its-role-in-the-cytokine-network
#12
Hyun A Kim, Nyoun Soo Kwon, Kwang Jin Baek, Dong-Seok Kim, Hye-Young Yun
Leucine-rich glioma inactivated (LGI)3 is a secreted protein member of LGI family. We previously repo-rted that LGI3 was upregulated in adipose tissues from obese mice and suppressed adipogenesis through its receptor, a disintegrin and metalloproteinase domain-containing protein 23 (ADAM23). We demonstrated that LGI3 regulated tumor necrosis factor-α and adiponectin, and proposed that LGI3 may be a pro-inflammatory adipokine involved in adipose tissue inflammation. In this study, we analyzed adipokine and cytokine profiles in LGI3 knockout mice and demonstrated that multiple factors were increased or decreased in the adipose tissues and plasma of the LGI3 knockout mice...
May 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28531113/retrospective-evaluation-of-metformin-and-or-metformin-plus-a-new-polysaccharide-complex-in-treating-severe-hyperinsulinism-and-insulin-resistance-in-obese-children-and-adolescents-with-metabolic-syndrome
#13
Stefano Stagi, Franco Ricci, Martina Bianconi, Maria Amina Sammarco, Giovanna Municchi, Sonia Toni, Lorenzo Lenzi, Alberto Verrotti, Maurizio de Martino
Background: Pharmacological treatment of obesity and glucose-insulin metabolism disorders in children may be more difficult than in adults. Thus, we evaluate the effects of metformin in comparison with metformin plus a polysaccharide complex (Policaptil Gel Retard(®), PGR) on body weight and metabolic parameters in obese children and adolescents with metabolic syndrome (MetS). Patients and methods: We retrospectively collected 129 children and adolescents (67 girls, 62 boys; median age 12.6 years) treated for a minimum of two years with metformin and low glycemic index (LGI) diet...
May 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28500416/effects-of-breaking-up-prolonged-sitting-following-low-and-high-glycaemic-index-breakfast-consumption-on-glucose-and-insulin-concentrations
#14
Daniel P Bailey, Benjamin D Maylor, Charlie J Orton, Julia K Zakrzewski-Fruer
PURPOSE: Breaking up prolonged sitting can attenuate the postprandial rise in glucose and insulin. Whether such effects are dependent of the glycaemic index (GI) of the consumed carbohydrate is unknown. This study examined the acute effects of breaking up prolonged sitting following a low GI and a high GI breakfast on postprandial glucose and insulin concentrations. PROCEDURES: Fourteen adult males aged 22.1 ± 1.2 years completed four, 4 h experimental conditions: high GI breakfast followed by uninterrupted sitting (HGI-SIT), low GI breakfast followed by uninterrupted sitting (LGI-SIT), high GI breakfast followed by 2 min activity breaks every 20 min (HGI-ACT), and low GI breakfast followed by 2 min activity breaks every 20 min (LGI-ACT)...
July 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28417232/healthy-cortical-development-through-adolescence-and-early-adulthood
#15
Natalie J Forde, Lisa Ronan, Marcel P Zwiers, Lizanne J S Schweren, Aaron F Alexander-Bloch, Barbara Franke, Stephen V Faraone, Jaap Oosterlaan, Dirk J Heslenfeld, Catharina A Hartman, Jan K Buitelaar, Pieter J Hoekstra
Adolescence is a period of significant brain changes; however, the effects of age and sex on cortical development are yet to be fully characterized. Here, we utilized innovative intrinsic curvature (IC) analysis, along with the traditional cortical measures [cortical thickness (CT), local gyrification index (LGI), and surface area (SA)], to investigate how these indices (1) relate to each other and (2) depend on age and sex in adolescent cortical development. T1-weighted magnetic resonance images from 218 healthy volunteers (age range 8...
April 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28383695/effect-of-pre-exercise-carbohydrate-diets-with-high-vs-low-glycemic-index-on-exercise-performance-a-meta-analysis
#16
Stephen Heung-Sang Wong, Feng-Hua Sun, Ya-Jun Chen, Chunxiao Li, Yan-Jie Zhang, Wendy Ya-Jun Huang
Context: Although pre-exercise consumption of a low-glycemic-index (LGI) carbohydrate meal is generally recommended, the findings regarding subsequent exercise performance are inconsistent. Objective: This meta-analytic study was conducted to determine whether a pre-exercise LGI carbohydrate meal leads to greater endurance performance than a pre-exercise high-glycemic-index (HGI) meal. Data sources: The following electronic databases were searched until April 2016: MEDLINE, SPORTDiscus, Web of Science, and Cochrane Central Register of Controlled Trials...
May 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28334078/relationships-between-morphologic-and-functional-patterns-in-the-polymicrogyric-cortex
#17
Matteo Lenge, Carmen Barba, Domenico Montanaro, Gayane Aghakhanyan, Francesca Frijia, Renzo Guerrini
Polymicrogyria is a malformation of cortical folding and layering underlying different cognitive and neurological manifestations. The polymicrogyric cortex has heterogeneous morphofunctional patterns, qualitatively described at magnetic resonance imaging (MRI) by variable severity gradients and functional activations. We investigated the link between abnormal cortical folding and cortical function in order to improve surgical planning for patients with polymicrogyria and intractable epilepsy. We performed structural and functional MRI on 14 patients with perisylvian polymicrogyria and adopted surface-based methods to detect alterations of cortical thickness (CT) and local gyrification index (LGI) compared with normal cortex (30 age-matched subjects)...
February 18, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28326021/abnormalities-in-structural-covariance-of-cortical-gyrification-in-parkinson-s-disease
#18
Jinping Xu, Jiuquan Zhang, Jinlei Zhang, Yue Wang, Yanling Zhang, Jian Wang, Guanglin Li, Qingmao Hu, Yuanchao Zhang
Although abnormal cortical morphology and connectivity between brain regions (structural covariance) have been reported in Parkinson's disease (PD), the topological organizations of large-scale structural brain networks are still poorly understood. In this study, we investigated large-scale structural brain networks in a sample of 37 PD patients and 34 healthy controls (HC) by assessing the structural covariance of cortical gyrification with local gyrification index (lGI). We demonstrated prominent small-world properties of the structural brain networks for both groups...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28290070/parieto-frontal-gyrification-and-working-memory-in-healthy-adults
#19
Sophie Green, Karen Blackmon, Thomas Thesen, Jonathan DuBois, Xiuyuan Wang, Eric Halgren, Orrin Devinsky
Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This study investigates whether regional variation in gyrification is associated with domain-general and domain-specific cognition. Our hypothesis is that increased local gyrification confers a functional advantage that is independent of surface area...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28257853/cortical-features-of-distinct-developmental-trajectories-in-patients-with-delusional-infestation
#20
Dusan Hirjak, Markus Huber, Erwin Kirchler, Katharina M Kubera, Martin Karner, Fabio Sambataro, Roland W Freudenmann, Robert C Wolf
BACKGROUND: Although there is strong neuroimaging evidence that cortical alterations are a core feature of schizophrenia spectrum disorders, it still remains unclear to what extent such abnormalities occur in monothematic delusional disorders. In individuals with delusional infestation (DI), the delusional belief to be infested with pathogens, previous structural MRI studies have shown prefrontal, temporal, parietal, insular, thalamic and striatal gray matter volume changes. Differential contributions of cortical features of evolutionary and genetic origin (such as cortical thickness, area and folding) which may distinctly contribute to DI pathophysiology are unclear at present...
February 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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