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https://www.readbyqxmd.com/read/27990776/sglt2-inhibitor-use-and-dietary-carbohydrate-intake-in-japanese-individuals-with-type-2-diabetes-a-randomized-open-label-3-arm-parallel-comparative-exploratory-study
#1
Daisuke Yabe, Masahiro Iwasaki, Hitoshi Kuwata, Takuya Haraguchi, Yoshiyuki Hamamoto, Takeshi Kurose, Kiminobu Sumita, Hitoshi Yamazato, Shigeto Kanada, Yutaka Seino
This study investigated safety and efficacy of the SGLT2 inhibitor luseogliflozin under differing carbohydrate intake in Japanese individuals with type 2 diabetes (T2D). Subjects were randomly assigned to three carbohydrate-adjusted meals for 14 days (Days 1-14) [HC-HGI, 55% total energy carbohydrate (TEC) and high glycemic index (GI); HC-LGI, 55% TEC and low GI; and LC-HGI, 40% TEC and high GI]. All subjects received luseogliflozin for the last 7 days (Days 8-14); continuous glucose monitoring (CGM) before and after luseogliflozin treatment (Days 5-8 and Days 12-15); and blood tests on Days 1, 8, and 15...
December 19, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27938423/hypogyrification-in-obsessive-compulsive-disorder
#2
O G Rus, T J Reess, G Wagner, M Zaudig, C Zimmer, K Koch
BACKGROUND: Previous studies hypothesized that neurodevelopmental risk factors may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Cortical folding has been shown to be a reliable indicator for normal and altered neurodevelopment, but in OCD it has barely been investigated up to now. The present study investigates whether alterations in gyrification are detectable in OCD and, if so, how these are associated with clinical characteristics. METHOD: We compared the local Gyrification Index (lGI) between 75 OCD patients and 75 matched healthy subjects across the whole brain...
December 12, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27901261/imaging-findings-in-faciobrachial-dystonic-seizures-associated-with-lgi-1-antibodies
#3
Ronnyson Susano Grativvol, Mateus Mistieri Simabukuro, Raphael Ribeiro Spera, Wagner Cid Palmeira Cavalcante, Hugo Henrique Soares Araújo, Daniel Sakuno, Leandro Tavares Lucato, Lécio Figueira Pinto, Luiz Henrique Martins Castro, Ricardo Nitrini
No abstract text is available yet for this article.
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27898350/cronkhite-canada-syndrome-complicated-by-pulmonary-embolism-a-case-report
#4
Neha L Nemade, Urvi B Shukla, Gajanan D Wagholikar
INTRODUCTION: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Since there is wide variability in medical presentation, no definitive diagnostic and treatment protocol s have been set. The mortality remains at 55%. CASE PRESENTATION: We report a case of a 50 year old male patient presenting with diarrhea, weight loss, abdominal pain, ectodermal features...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27884550/effects-of-changing-the-amount-and-source-of-dietary-carbohydrates-on-symptoms-and-dietary-satisfaction-over-a-1-year-period-in-subjects-with-type-2-diabetes-canadian-trial-of-carbohydrates-in-diabetes-ccd
#5
Thomas M S Wolever, Jean-Louis Chiasson, Robert G Josse, Lawrence A Leiter, Pierre Maheux, Rémi Rabasa-Lhoret, N Wilson Rodger, Edmond A Ryan
OBJECTIVES: To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS: Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index (HGI) diets; high-carbohydrate/low-glycemic-index (LGI) diets; or lower-carbohydrate/high-monounsaturated-fat (LC) diets for 1 year. We measured QOL at baseline and at study's end, and we measured symptoms and dietary satisfaction quarterly...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27873466/cortical-folding-in-post-traumatic-stress-disorder-after-motor-vehicle-accidents-regional-differences-in-gyrification
#6
Chun Chu, Mingguo Qiu, Kaijun Liu, Liwen Tan, Yi Wu, Bing Xie, Wei Chen, Shaoxiang Zhang
AIM: Structural and functional magnetic resonance imaging (MRI) studies have revealed evidence of brain abnormalities in post-traumatic stress disorder (PTSD) patients. Cortical complexity and local gyrification index (lGI) reflects potential biological processes associated with normal or abnormal cognitive functioning. In the current study, lGI is used to explore cortical folding in PTSD patients involved in motor vehicle accidents (MVCs). METHODS: MRI brain scans were acquired from 18PTSD patients who suffered MVCs at least 6 months previously and 18 healthy control subjects...
November 21, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27828960/cortical-morphology-differences-in-subjects-at-increased-vulnerability-for-developing-a-psychotic-disorder-a-comparison-between-subjects-with-ultra-high-risk-and-22q11-2-deletion-syndrome
#7
Geor Bakker, Matthan W A Caan, Wilhelmina A M Vingerhoets, Fabiana da Silva-Alves, Mariken de Koning, Erik Boot, Dorien H Nieman, Lieuwe de Haan, Oswald J Bloemen, Jan Booij, Thérèse A M J van Amelsvoort
INTRODUCTION: Subjects with 22q11.2 deletion syndrome (22q11DS) and subjects with ultra-high risk for psychosis (UHR) share a risk of approximately 30% to develop a psychotic disorder. Studying these groups helps identify biological markers of pathophysiological processes involved in the development of psychosis. Total cortical surface area (cSA), total cortical grey matter volume (cGMV), cortical thickness (CT), and local gyrification index (LGI) of the cortical structure have a distinct neurodevelopmental origin making them important target markers to study in relation to the development of psychosis...
2016: PloS One
https://www.readbyqxmd.com/read/27743376/cortical-folding-patterns-are-associated-with-impulsivity-in-healthy-young-adults
#8
Dusan Hirjak, Anne K Thomann, Katharina M Kubera, Robert C Wolf, Haang Jeung, Klaus H Maier-Hein, Philipp A Thomann
Impulsivity is associated with distinct mental disorders but is also considered as a personality trait exhibited by healthy individuals. Current studies suggest that early stressful life events might cause higher impulsivity in the adulthood. Morphological features, which reflect early brain development, could provide valuable information regarding the origin of impulsive behavior. However, none of the previous MRI studies employed a methodology specifically designed to investigate the relationship between impulsivity and markers of brain development...
October 14, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27701463/low-grade-inflammation-is-associated-with-susceptibility-to-infection-in-healthy-men-results-from-the-danish-blood-donor-study-dbds
#9
Kathrine Agergård Kaspersen, Khoa Manh Dinh, Lise Tornvig Erikstrup, Kristoffer Sølvsten Burgdorf, Ole Birger Pedersen, Erik Sørensen, Mikkel Steen Petersen, Henrik Hjalgrim, Klaus Rostgaard, Kaspar Rene Nielsen, Henrik Ullum, Christian Erikstrup
INTRODUCTION: The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection. METHODS: We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register...
2016: PloS One
https://www.readbyqxmd.com/read/27688214/the-clinical-utility-of-over-the-scope-clip-for-the-treatment-of-gastrointestinal-defects
#10
Ido Mizrahi, Rana Eltawil, Nadav Haim, Sami A Chadi, Bo Shen, Tolga Erim, Giovanna DaSilva, Steven D Wexner
BACKGROUND: The over-the-scope clip (OTSC) is a novel endoscopic tool that enables non-surgical management of gastrointestinal (GI) defects. The aim of this study was to report our experience with OTSC for patients with GI defects. METHODS: A prospectively maintained IRB-approved institutional database was queried for all patients treated with OTSC from 2012 to 2015. Primary outcome was the clinical success of the OTSC for the individual indication. Secondary outcome was the number of additional procedures needed following OTSC...
September 29, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27677914/effect-of-glycemic-index-of-a-pre-exercise-meal-on-endurance-exercise-performance-a-systematic-review-and-meta-analysis
#11
Catriona A Burdon, Inge Spronk, Hoi Lun Cheng, Helen T O'Connor
BACKGROUND: Low glycemic index (GI) pre-exercise meals may enhance endurance performance by maintaining euglycemia and altering fuel utilization. However, evidence for performance benefits is equivocal. OBJECTIVE: To evaluate the effect of a low GI (LGI) versus a high GI (HGI) pre-exercise meal on endurance performance using meta-analyses. METHODS: Data sources included MEDLINE, SPORTDiscus, AUSPORT, AusportMed, Web of Science, and Scopus...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27598983/low-glycemic-index-diet-reduces-body-fat-and-attenuates-inflammatory-and-metabolic-responses-in-patients-with-type-2-diabetes
#12
Júnia Maria Geraldo Gomes, Sabrina Pinheiro Fabrini, Rita de Cássia Gonçalves Alfenas
Objective: The aim of this study was to verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations in patients with type 2 diabetes. Subjects and methods: In this randomized controlled parallel trial, twenty subjects (aged 42.4 ± 5.1 years, BMI 29.2 ± 4.8 kg.m-2) were allocated to low GI (LGI) (n = 10) or high GI (HGI) (n = 10) groups. Body composition, inflammatory and metabolic markers were assessed at baseline and after 30 days of intervention...
September 5, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27593525/increased-liver-fat-and-glycogen-stores-after-consumption-of-high-versus-low-glycaemic-index-food-a-randomized-crossover-study
#13
Stephen Bawden, Mary Stephenson, Yirga Falcone, Melanie Lingaya, Elisabetta Ciampi, Karl Hunter, Frances Bligh, Jörg Schirra, Moira Taylor, Peter Morris, Ian Macdonald, Penny Gowland, Luca Marciani, Guruprasad P Aithal
AIM: To investigate the acute and longer-term effects of low (LGI) versus high glycaemic index (HGI) diets on hepatic fat and glycogen accumulation and related blood measures in healthy volunteers. METHODS: Eight healthy men (age 20.1 ± 0.4 years, body mass index 23.0 ± 0.9 kg/m(2) ) attended a test day before and after a 7-day macronutrient- and energy-matched HGI or LGI diet, followed by a minimum 4-week wash-out period, and then returned to repeat the intervention with the alternative diet...
January 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27499751/evolution-and-diversity-of-listeria-monocytogenes-from-clinical-and-food-samples-in-shanghai-china
#14
Jianmin Zhang, Guojie Cao, Xuebin Xu, Marc Allard, Peng Li, Eric Brown, Xiaowei Yang, Haijian Pan, Jianghong Meng
Listeria monocytogenes is a significant foodborne pathogen causing severe systemic infections in humans with high mortality rates. The objectives of this work were to establish a phylogenetic framework of L. monocytogenes from China and to investigate sequence diversity among different serotypes. We selected 17 L. monocytogenes strains recovered from patients and foods in China representing serotypes 1/2a, 1/2b, and 1/2c. Draft genome sequences were determined using Illumina MiSeq technique and associated protocols...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27426957/evaluation-of-iron-deficiency-anaemia-for-gastrointestinal-causes-in-patients-without-gi-symptoms-in-high-prevalent-gi-malignancy-zones
#15
Showkat A Kadla, Nisar A Shah, Muzafar A Bindroo, Bilal A Khan, Adil Farooq, Wajeed Yousf, Bilal A Wani
BACKGROUND AND STUDY AIMS: Gastric cancer is highly prevalent in Kashmir, as are lower gastrointestinal (LGI) malignancies. Colonic cancer, gastric cancer, and coeliac disease are the most important gastrointestinal (GI) causes of iron deficiency anaemia (IDA) worldwide. Approximately 9% of patients with IDA present with a suspicious lesion in the GI tract upon examination. However, the absence of GI symptoms and a possible lesion accounting for blood loss in IDA have not been studied in this zone with a high prevalence of GI malignancy...
June 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27406561/lectin-glycan-interaction-network-based-identification-of-host-receptors-of-microbial-pathogenic-adhesins
#16
Francesco S Ielasi, Mitchel Alioscha-Perez, Dagmara Donohue, Sandra Claes, Hichem Sahli, Dominique Schols, Ronnie G Willaert
UNLABELLED: The first step in the infection of humans by microbial pathogens is their adherence to host tissue cells, which is frequently based on the binding of carbohydrate-binding proteins (lectin-like adhesins) to human cell receptors that expose glycans. In only a few cases have the human receptors of pathogenic adhesins been described. A novel strategy-based on the construction of a lectin-glycan interaction (LGI) network-to identify the potential human binding receptors for pathogenic adhesins with lectin activity was developed...
2016: MBio
https://www.readbyqxmd.com/read/27376698/the-effect-of-consuming-low-versus-high-glycemic-index-meals-after-exercise-on-postprandial-blood-lipid-response-following-a-next-day-high-fat-meal
#17
M Kaviani, P D Chilibeck, P Yee, G A Zello
BACKGROUND/OBJECTIVES: Exercise performed shortly before (that is, within half a day of) a high-fat meal is beneficial for stimulating fat oxidation after the meal and reducing postprandial triglycerides (TG). This benefit of exercise is unfortunately negated if the after-exercise food choice to replace the calories expended during exercise is one containing high-glycemic index (HGI) carbohydrates. We determined the effect of consuming low-glycemic index (LGI) carbohydrates after an exercise session on fat oxidation and TG after a subsequent high-fat meal...
July 4, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27320849/effects-of-long-term-diving-training-on-cortical-gyrification
#18
Yuanchao Zhang, Lu Zhao, Wenwei Bi, Yue Wang, Gaoxia Wei, Alan Evans, Tianzi Jiang
During human brain development, cortical gyrification, which is believed to facilitate compact wiring of neural circuits, has been shown to follow an inverted U-shaped curve, coinciding with the two-stage neurodevelopmental process of initial synaptic overproduction with subsequent pruning. This trajectory allows postnatal experiences to refine the wiring, which may manifest as endophenotypic changes in cortical gyrification. Diving experts, typical elite athletes who commence intensive motor training at a very young age in their early childhood, serve ideal models for examining the gyrification changes related to long-term intensive diving training...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27258651/cardiovascular-outcomes-following-rotational-atherectomy-a-uk-multicentre-experience
#19
Christos Eftychiou, David S Barmby, Simon J Wilson, Salahaddin Ubaid, Andrew J Markwick, Loukia Makri, Jonathan M Blaxill, James C Spratt, Mark Gunning, John P Greenwood
OBJECTIVES: To identify factors associated with outcomes following rotational atherectomy (RA). BACKGROUND: RA is an effective way to mechanically modify heavily calcified lesions before stenting; however its outcomes are not well defined. METHODS AND RESULTS: Retrospective evaluation of all patients who underwent RA in three large UK centers (Leeds General Infirmary (LGI), Royal Infirmary of Edinburgh (RIE) and University Hospital of North Staffordshire (UHNS)) from March 2005 to January 2013...
June 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27258511/effects-of-low-glycemic-index-diets-on-gestational-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-clinical-trials
#20
Jinhua Wei, Weijun Heng, Jianbo Gao
Studies of the effects of low glycemic index (LGI) diets on gestational diabetes mellitus (GDM) have reported conflicting findings.The aim of the study was to evaluate the results of randomized controlled trials (RCTs) that investigated the effects of LGI diets with and without added dietary fiber (DF) on maternal and neonatal outcomes in GDM patients.We searched the MEDLINE, EMBASE, EBSCO, Springer, Ovid, and Cochrane Library databases for studies of the effects of LGI diets in GDM patients. We performed a meta-analysis of the effects of the LGI diets with and without added dietary fiber (DF) on GDM outcomes...
May 2016: Medicine (Baltimore)
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