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https://www.readbyqxmd.com/read/29771820/effect-of-lgi1-antibody-positive-igg-on-hippocampal-neuron-survival-a-preliminary-study
#1
Neşe Ayşit-Altuncu, Canan Ulusoy, Gürkan Öztürk, Erdem Tüzün
Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is one of the most frequently encountered forms of autoimmune encephalitis. Many patients with anti-LGI1 encephalitis develop permanent hippocampal neuron loss and chronic neuropsychiatric symptoms, suggesting that LGI antibodies (Ab) might have a neurotoxic action. To investigate this hypothesis, purified serum IgG of three patients with anti-LGI1 encephalitis and six healthy controls were incubated with cultured primary hippocampal neurons obtained from newborn mice...
May 15, 2018: Neuroreport
https://www.readbyqxmd.com/read/29771286/local-cortical-gyrification-is-increased-in-children-with-autism-spectrum-disorders-but-decreases-rapidly-in-adolescents
#2
Jiwandeep S Kohli, Mikaela K Kinnear, Christopher H Fong, Inna Fishman, Ruth A Carper, Ralph-Axel Müller
Extensive MRI evidence indicates early brain overgrowth in autism spectrum disorders (ASDs). Local gyrification may reflect the distribution and timing of aberrant cortical expansion in ASDs. We examined MRI data from (Study 1) 64 individuals with ASD and 64 typically developing (TD) controls (7-19 years), and from (Study 2) an independent sample from the Autism Brain Imaging Data Exchange (n = 31/group). Local Gyrification Index (lGI), cortical thickness (CT), and surface area (SA) were measured. In Study 1, differences in lGI (ASD > TD) were found in left parietal and temporal and right frontal and temporal regions...
May 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29764220/wide-range-crp-versus-high-sensitivity-crp-on-roche-analyzers-focus-on-low-grade-inflammation-ranges-and-high-sensitivity-cardiac-troponin-t-levels
#3
Denis Monneret, Fouzi Mestari, Shaedah Djiavoudine, Guillaume Bachelot, Maxime Cloison, Françoise Imbert-Bismut, Maguy Bernard, Pierre Hausfater, Jean-Marc Lacorte, Dominique Bonnefont-Rousselot
Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland-Altman method; Deming's correlation), then separately classified into low (<1 mg/L), moderate (1-3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming's regression-based adjustment of wr-CRP (Adj-wr-CRP)...
May 15, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29739476/altered-brain-gyrification-in-deficit-and-non-deficit-schizophrenia
#4
Yoichiro Takayanagi, Daiki Sasabayashi, Tsutomu Takahashi, Yuko Komori, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Mihoko Nakamura, Kyo Noguchi, Michio Suzuki
BACKGROUND: Patients with the deficit form of schizophrenia (D-SZ) are characterized by severe primary negative symptoms and differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects. No study has measured brain gyrification, which is a potential marker of neurodevelopment, in D-SZ and ND-SZ. METHODS: We obtained magnetic resonance scans from 135 schizophrenia patients and 50 healthy controls. The proxy scale for deficit syndrome (PDS) was used for the classification of D-SZ and ND-SZ...
May 9, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29718689/comparative-effects-of-different-dietary-approaches-on-blood-pressure-in-hypertensive-and-pre-hypertensive-patients-a-systematic-review-and-network-meta-analysis
#5
Lukas Schwingshackl, Anna Chaimani, Carolina Schwedhelm, Estefania Toledo, Marina Pünsch, Georg Hoffmann, Heiner Boeing
BACKGROUND: Pairwise meta-analyses have shown beneficial effects of individual dietary approaches on blood pressure but their comparative effects have not been established. OBJECTIVE: Therefore we performed a systematic review of different dietary intervention trials and estimated the aggregate blood pressure effects through network meta-analysis including hypertensive and pre-hypertensive patients. DESIGN: PubMed, Cochrane CENTRAL, and Google Scholar were searched until June 2017...
May 2, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29712816/teaching-video-neuroimages-acquired-focal-neuromyotonia-in-lgi-1-autoimmunity
#6
A Sebastian López Chiriboga, Joseph Matsumoto, Eric Sorenson, Christopher J Klein, Andrew McKeon
No abstract text is available yet for this article.
May 1, 2018: Neurology
https://www.readbyqxmd.com/read/29680574/subcortical-volume-and-cortical-surface-architecture-in-women-with-acute-and-remitted-anorexia-nervosa-an-exploratory-neuroimaging-study
#7
Amy E Miles, Aristotle N Voineskos, Leon French, Allan S Kaplan
BACKGROUND: Anorexia nervosa (AN) is a highly heritable psychiatric disorder characterized by starvation and emaciation and associated with changes in brain structure. The precise nature of these changes remains unclear, as does their developmental time course and capacity for reversal with weight-restoration. In this comprehensive neuroimaging study, we sought to characterize these changes by measuring subcortical volume and cortical surface architecture in women with acute and remitted AN...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29676856/age-related-changes-in-cortical-and-subcortical-structures-of-healthy-adult-brains-a-surface-based-morphometry-study
#8
Fenglian Zheng, Yulin Liu, Zilong Yuan, Xiaodong Gao, Yaoyao He, Xiaojing Liu, Dong Cui, Rui Qi, Tiao Chen, Jianfeng Qiu
BACKGROUND: Cerebral structures in both cortical and subcortical regions change with aging. More specific and comprehensive studies are needed to better elucidate these changes. PURPOSE: To investigate the relationships between age and cerebral structures regarding cortical and subcortical changes. STUDY TYPE: Cross-cohort research. POPULATION: 54 healthy adults (28 females) aged 21-71 years. FIELD STRENGTH/SEQUENCE: T1 -weighted imaging was performed at 1...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29662481/-listeria-monocytogenes-sequence-types-121-and-14-repeatedly-isolated-within-one-year-of-sampling-in-a-rabbit-meat-processing-plant-persistence-and-ecophysiology
#9
Frédérique Pasquali, Federica Palma, Laurent Guillier, Alex Lucchi, Alessandra De Cesare, Gerardo Manfreda
Listeria monocytogenes is a foodborne pathogen adapted to survive and persist in multiple environments. Following two previous studies on prevalence and virulence of L. monocytogenes ST121 and ST14 repeatedly collected in a the same rabbit-meat processing plant, the research questions of the present study were to: (1) assess persistence of L. monocytogenes isolates from the rabbit-plant; (2) select genes associated to physiological adaptation to the food-processing environment; (3) compare presence/absence/truncation of these genes in newly sequenced and publicly available ST121 and ST14 genomes...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29649949/postprandial-effects-of-breakfast-glycaemic-index-on-cognitive-performance-among-young-healthy-adults-a-crossover-clinical-trial
#10
Natalia Sanchez-Aguadero, Jose I Recio-Rodriguez, Maria C Patino-Alonso, Sara Mora-Simon, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado, Manuel A Gomez-Marcos, Luis Garcia-Ortiz
OBJECTIVE: To evaluate the postprandial effects of high and low glycaemic index (GI) breakfasts on cognitive performance in young, healthy adults. METHODS: A crossover clinical trial including 40 young, healthy adults (aged 20-40 years, 50% females) recruited from primary healthcare centres in Salamanca, Spain. Verbal memory, phonological fluency, attention, and executive functions were examined 0, 60, and 120 minutes after consuming a low GI (LGI), high GI (HGI), or water breakfast...
April 12, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29603657/changes-in-plasma-metabolite-concentrations-after-a-low-glycemic-index-diet-intervention
#11
Pablo Hernández-Alonso, Simona Giardina, Daniel Cañueto, Jordi Salas-Salvadó, Nicolau Cañellas, Mònica Bulló
SCOPE: To examine whether a low-glycemic index (LGI) diet improves a set of plasma metabolites related to different metabolic diseases and compared to a high-glycemic index (HGI) diet and a low-fat (LF) diet. METHODS AND RESULTS: We conducted a parallel, randomized trial with three intervention diets: a LGI diet, a HGI diet and a LF diet. A total of 122 adult overweight and obese subjects were enrolled in the study for 6 months. Blood samples were collected at baseline and at the end of the intervention...
March 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29562613/effects-of-low-versus-moderate-glycemic-index-diets-on-aerobic-capacity-in-endurance-runners-three-week-randomized-controlled-crossover-trial
#12
Krzysztof Durkalec-Michalski, Emilia E Zawieja, Bogna E Zawieja, Dominika Jurkowska, Maciej S Buchowski, Jan Jeszka
The glycemic index (GI) of ingested carbohydrates may influence substrate oxidation during exercise and athletic performance. Therefore, the aim of this study was to assess the effect of low- and moderate-GI three-week diets on aerobic capacity and endurance performance in runners. We conducted a randomized crossover feeding study of matched diets differing only in GI (low vs. moderate) in 21 endurance-trained runners. Each participant consumed both, low- (LGI) and moderate-GI (MGI) high-carbohydrate (~60%) and nutrient-balanced diets for three weeks each...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29522031/reduction-of-the-defocusing-effect-in-lensless-ghost-imaging-and-ghost-diffraction-with-cosh-gaussian-modulated-incoherent-sources
#13
Chao Duan, Yanfeng Bai, Lingli Tang, Suqin Nan, Qian Shen, Xiquan Fu
The inhibition effect from the cosh-Gaussian modulated incoherent source on the defocusing effect is investigated theoretically in lensless ghost imaging (LGI) and ghost diffraction (LGD) systems. The corresponding numerical simulations are presented to show the influence of the cosh-Gaussian incoherent source on the defocusing effect in LGI and LGD. Compared with the widely used Gaussian incoherent source, it is shown that the defocusing effect in LGI and LGD can be greatly weakened by properly adjusting the modulation parameter ω of the cosh-Gaussian source...
March 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29492373/indigenous-plant-growth-promoting-bacteria-enhance-plant-growth-biomass-and-nutrient-uptake-in-degraded-forest-plants
#14
Parthasarathy Radhapriya, Andimuthu Ramachandran, Perumal Palani
The present study was aimed to isolate indigenous plant growth-promoting bacteria (PGPB) from Nanmangalam reserve forest, India and to analyze their positive impact on nursery plant species. In total, 160 isolates were obtained from different nitrogen-free Media (LGI, JMV, NFB). Amongst these, 12 isolates were shown positive for 5-8% of ammonia production nif H positive and then isolates were further tested for their plant growth-promoting (PGP) activity. Based on their PGP activity, nine isolates were selected, and applied in nurseries of twelve native plant species, along with organic manure and inorganic fertilizer...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29486453/two-year-cortical-trajectories-are-abnormal-in-children-and-adolescents-with-prenatal-alcohol-exposure
#15
Timothy J Hendrickson, Bryon A Mueller, Elizabeth R Sowell, Sarah N Mattson, Claire D Coles, Julie A Kable, Kenneth L Jones, Christopher J Boys, Susanne Lee, Kelvin O Lim, Edward P Riley, Jeffrey R Wozniak
OBJECTIVES: Cortical abnormalities in prenatal alcohol exposure (PAE) are known, including in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides longitudinal and developmental context to the PAE cortical development literature. EXPERIMENTAL DESIGN: Included: 58 children with PAE and 52 controls, ages 6-17 at enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants underwent a formal evaluation of physical anomalies and dysmorphic facial features associated with PAE...
April 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29484761/heme-oxygenase-1-deficiency-results-in-splenic-t-cell-dysregulation-in-offspring-of-mothers-exposed-to-late-gestational-inflammation
#16
Maide Ozen, Hui Zhao, Flora Kalish, Yang Yang, Ann Folkins, Irina Burd, Ronald J Wong, David K Stevenson
PROBLEM: Infection during pregnancy can disrupt regulatory/effector immune system balance, resulting in adverse pregnancy and fetal-neonatal outcomes. Heme oxygenase-1 (HO-1) is a major regulatory enzyme in the immune system. We observed maternal immune response dysregulation during late gestational inflammation (LGI), which may be mediated by HO-1. Here, we extend these studies to examine the immune response of offspring. METHOD OF STUDY: Pregnant wild-type (Wt) and HO-1 heterozygote (Het) dams were treated with lipopolysaccharide (LPS) or vehicle at E15...
May 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29397673/limbic-encephalitis-manifesting-as-selective-amnesia-and-seizure-like-activity-a-case-report
#17
So-Yeon Kim, Yoo Hyun Um, Sung Chul Lim, Jong-Hyun Jeong
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related LE who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29385604/mri-indices-of-cortical-development-in-young-people-with-psychotic-experiences-influence-of-genetic-risk-and-persistence-of-symptoms
#18
Leon Fonville, Mark Drakesmith, Stanley Zammit, Glyn Lewis, Derek K Jones, Anthony S David
Background: Psychotic experiences (PEs) are considered part of an extended psychosis phenotype and are associated with an elevated risk of developing a psychotic disorder. Risk of transition increases with persistence of PEs, and this is thought to be modulated by genetic and environmental factors. However, it is unclear if persistence is associated with progressive schizophrenia-like changes in neuroanatomy. Methods: We examined cortical morphometry using MRI in 247 young adults, from a population-based cohort, assessed for the presence of PEs at ages 18 and 20...
January 29, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29382142/the-influence-of-pre-exercise-glucose-versus-fructose-ingestion-on-subsequent-postprandial-lipemia
#19
Tsung-Jen Yang, Chih-Hui Chiu, Mei-Hui Tseng, Cheng-Kang Chang, Ching-Lin Wu
Ingestion of low glycemic index (LGI) carbohydrate (CHO) before exercise induced less insulin response and higher fat oxidation than that of high GI (HGI) CHO during subsequent exercise. However, the effect on the subsequent postprandial lipid profile is still unclear. Therefore, the aim of this study was to investigate ingestion of CHO drinks with different GI using fructose and glucose before endurance exercise on the subsequent postprandial lipid profile. Eight healthy active males completed two experimental trials in randomized double-blind cross-over design...
January 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29305294/cortical-folding-abnormalities-in-patients-with-schizophrenia-who-have-persistent-auditory-verbal-hallucinations
#20
Katharina M Kubera, Philipp A Thomann, Dusan Hirjak, Anja Barth, Fabio Sambataro, Nenad Vasic, Nadine D Wolf, Karel Frasch, R Christian Wolf
In schizophrenia temporal cortical volume loss differs between patients presenting with persistent auditory verbal hallucinations (pAVH) in contrast to those without hallucinatory symptoms (nAVH). However, it is unknown whether this deficit reflects a neural signature of neurodevelopmental origin or if abnormal temporal cortical volume is reflective of factors which may be relevant at later stages of the disorder. Here, we tested the hypothesis that local gyrification index (LGI) in regions of the temporal cortex differs between patients with pAVH (n=10) and healthy controls (n=14), and that abnormal temporal LGI discriminates between pAVH and nAVH (n=10)...
February 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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