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Pulmonary serum marker

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https://www.readbyqxmd.com/read/28526204/the-786-t-c-polymorphism-of-nos3-gene-is-a-susceptibility-marker-of-copd-among-tunisians-that-correlates-with-nitric-oxide-levels-and-airflow-obstruction
#1
Hela Ben Nasr, Sarra Bchir, Amel Ben Anes, Asma Amri, Yosra Sakhana, Mohamed Benzarti, Abdelhamid Garrouch, Zouhair Tabka, Karim Chahed
OBJECTIVE: The goal of this study was to examine the role of G894T (rs1799983), -786T/C (rs3918161) and a 27 bp variable number of tandem repeats (VNTR) 4B/4A of NOS3 gene on the risk and severity of COPD. METHODS: The study included 194 controls and 138 COPD patients. NOS3 G894T, -786T/C and 4B/4A variants were determined by PCR analysis based on the banding pattern on gel electrophoresis. Pulmonary function was evaluated using body plethysmography. The levels of nitric oxide, peroxynitrite and lipid peroxides (T-BARS) were determined using spectrophotometric methods...
May 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28496045/cholic-acid-enhances-visceral-adiposity-atherosclerosis-and-nonalcoholic-fatty-liver-disease-in-microminipigs
#2
Sohsuke Yamada, Hiroaki Kawaguchi, Tomonobu Yamada, Xin Guo, Kei Matsuo, Taiji Hamada, Naoki Miura, Takashi Tasaki, Akihide Tanimoto
AIM: We have recently established a novel swine model for studies of atherosclerosis using Microminipigs(TM) (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries. METHODS: The µMPs were fed HcD supplemented with 0.7% CA (HcD+CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adiposity and lesion formation in the aorta, liver, and other organs was investigated...
May 11, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28481326/the-dose-response-association-between-nitrogen-dioxide-exposure-and-serum-interleukin-6-concentrations
#3
Jennifer L Perret, Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Lyle C Gurrin, Rangi Kandane-Rathnayake, David P Johns, Adrian J Lowe, John A Burgess, Bruce R Thompson, Paul S Thomas, Richard Wood-Baker, Stephen Morrison, Graham G Giles, Guy Marks, James Markos, Mimi L K Tang, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
Systemic inflammation is an integral part of chronic obstructive pulmonary disease (COPD), and air pollution is associated with cardiorespiratory mortality, yet the interrelationships are not fully defined. We examined associations between nitrogen dioxide (NO₂) exposure (as a marker of traffic-related air pollution) and pro-inflammatory cytokines, and investigated effect modification and mediation by post-bronchodilator airflow obstruction (post-BD-AO) and cardiovascular risk. Data from middle-aged participants in the Tasmanian Longitudinal Health Study (TAHS, n = 1389) were analyzed by multivariable logistic regression, using serum interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α) as the outcome...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28474652/correlation-of-total-serum-immunoglobulin-e-level-sputum-and-peripheral-eosinophil-count-in-assessing-the-clinical-severity-in-bronchial-asthma
#4
Roshan M Kumar, R Pajanivel, G Koteeswaran, Surendra K Menon, Pravin Mv Charles
CONTEXT: Asthma is a chronic inflammatory disorder of the airway with involvement of various cellular populations and release of many inflammatory mediators. Eosinophils and serum immunoglobulin E (IgE) are considered a good marker of airway inflammation in asthma. The correlation of clinical assessment with various markers of airway inflammation in asthma is not well established in the Indian population. AIMS: This study aims to study the correlation of serum IgE, sputum eosinophil count, and peripheral eosinophil count with clinical severity of Asthma...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28474352/airway-basophils-are-increased-and-activated-in-eosinophilic-asthma
#5
Yoshihiro Suzuki, Keiko Wakahara, Tomoko Nishio, Satoru Ito, Yoshinori Hasegawa
BACKGROUND: The impact of basophils on asthma pathogenesis remains largely unexplored, particularly in humans. Here, we evaluated the frequencies and activation status of basophils in the sputum of adult asthmatic patients and related our findings to other parameters of eosinophilic airway inflammation. METHODS: We enrolled 44 adult asthmatic patients who were being treated with inhaled corticosteroids (ICS). Analysis of the induced sputum, exhaled nitric oxide fraction (FeNO) measurement, and Asthma Control Test (ACT) were carried out together with standard blood and pulmonary function tests...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28469720/a-study-of-chronic-obstructive-pulmonary-disease-specific-causes-of-osteoporosis-with-emphasis-on-the-emphysema-phenotype
#6
Mona Ali Fouda, Esam Hamad Alhamad, Mohammed Saleh Al-Hajjaj, Shaffi Ahmed Shaik, Ahmad Amer Alboukai, Feisal Abdulla Al-Kassimi
BACKGROUND: Osteoporosis, the most common extra-pulmonary complication of chronic obstructive pulmonary disease (COPD), may be related to general causes or COPD-specific causes such as low forced expiratory volume in 1 s (FEV1) and hypoxia. A few studies reported that emphysema is an independent risk factor for osteoporosis. However, other workers considered the association to be confounded by low FEV1 and low body mass index (BMI) which cluster with emphysema. AIMS: To study the association between osteoporosis and emphysema in a model that includes these potentially confounding factors...
April 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28458533/the-association-between-risk-of-airflow-limitation-and-serum-uric-acid-measured-at-medical-health-check-ups
#7
Atsuro Fukuhara, Junpei Saito, Suguru Sato, Kazue Saito, Naoko Fukuhara, Yoshinori Tanino, Xintao Wang, Katsuaki Rinno, Hitoshi Suzuki, Mitsuru Munakata
The prevalence of COPD and asthma is increasing all over the world; however, their morbidities are thought to be greatly underestimated because of unawareness of patients' conditions and respiratory symptoms. Spirometry is useful for the early detection of COPD and asthma with airflow limitation (AL), although it is not yet widely used for screening in epidemiological and primary care settings. A simple predictive marker used in combination with spirometry for AL is expected to be established. In medical health check-ups, serum uric acid (s-UA) is measured when screening for gout and has recently been suggested to have an association with several respiratory disorders, including asthma and COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28457921/serum-mirnas-as-potential-biomarkers-for-the-bronchiolitis-obliterans-syndrome-after-lung-transplantation
#8
K Budding, M Rossato, E A van de Graaf, J M Kwakkel-van Erp, T R D J Radstake, H G Otten
Lung transplantation (LTx) is the last treatment for patients suffering from end-stage lung diseases. Survival post-LTx is hampered by the development of the bronchiolitis obliterans syndrome (BOS) and diagnosis is often late. Given the urgent clinical need to recognize BOS patients at an early stage, we analyzed circulating miRNAs to identify possible stratification markers for BOS development post-transplantation. Therefore, pro-fibrotic (miR-21, miR-155), anti-fibrotic (miR-29a) and fibrosis-unrelated (miR-103, miR-191) miRNAs were analyzed in serum of end-stage lung disease patients and during LTx follow-up...
April 28, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28450224/pinocembrin-ex-vivo-preconditioning-improves-the-therapeutic-efficacy-of-endothelial-progenitor-cells-in-monocrotaline-induced-pulmonary-hypertension-in-rats
#9
Lamiaa A Ahmed, Sherine M Rizk, Shohda A El-Maraghy
Pulmonary hypertension is still not curable and the available current therapies can only alleviate symptoms without hindering the progression of disease. The present study was directed to investigate the possible modulatory effect of pinocembrin on endothelial progenitor cells transplanted in monocrotaline-induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous injection of monocrotaline (60 mg/kg). Endothelial progenitor cells was in vitro preconditioned with pinocembrin (25 mg/L) for 30 min before being i...
April 24, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28428699/putative-role-of-cardio-metabolic-risk-among-poorly-controlled-asthmatics-in-south-indian-population
#10
Murugaiyan Sathish Babu, K P Sreesoorya, Surendra K Menon, Subiman Saha, A R Srinivasan, S Arul Vijaya Vani, R Reeta, V Kuzhandai Velu
Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30)...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28421779/oral-glutamine-reduces-myocardial-damage-after-coronary-revascularization-under-cardiopulmonary-bypass-a-randomized-clinical-trial
#11
Mariana Chávez-Tostado, Fernando Carrillo-Llamas, Porfirio Eduardo Martínez-Gutiérrez, Araceli Alvarado-Ramírez, Jaime Gilberto López-Taylor, José Clemente Vásquez-Jiménez, Clotilde Fuentes-Orozco, Jorge Rendón-Félix, Leire Irusteta-Jiménez, Vanessa Carolina Calil-Romero, José Antonio Ramírez-Jiménez, Luis Rodrigo Michel-Espinoza, Carmen Karina Contreras-López, Lizbeth Araceli Cuesta-Márquez, Alejandro González-Ojeda
BACKGROUND: Glutamine is the most abundant free amino acid in the body. It modulates immune cell function and is an important energy substrate for cells in critically ill patients. Reduction of injury cardiac markers had been observed in patients receiving intravenous glutamine and in a pilot study with oral glutamine. The aim of this study was to analyze the effect of preoperative oral supplementation of glutamine on postoperative serum levels of cardiac injury markers. METHODS: A randomized clinical trial was performed in 28 Mexican patients with ischemic heart disease who underwent cardiopulmonary bypass with extracorporeal circulation...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420366/pirfenidone-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice-by-regulating-nrf2-bach1-equilibrium
#12
Yuan Liu, Fuai Lu, Lirong Kang, Zhihua Wang, Yongfu Wang
BACKGROUND: Oxidative stress is one of the important factors involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/antioxidation capacity. Pirfenidone (PFD) is one of two currently for IPF therapy approved drugs...
April 18, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28416955/down-regulation-of-serum-high-mobility-group-box-1-protein-in-patients-with-pulmonary-tuberculosis-and-nontuberculous-mycobacterial-lung-disease
#13
Su-Young Kim, Won-Jung Koh, Hye Yun Park, Kyeongman Jeon, Soo-Youn Lee, Jae-Joon Yim, Sung Jae Shin
BACKGROUND: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease. METHODS: A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28403662/diagnostic-efficacy-of-serum-amyloid-a-protein-and-soluble-intercellular-adhesion-molecule-1-in-pediatric-ventilator-associated-pneumonia
#14
Hamdy H Abo-Hagar, Ahmed Abd ElBasset Abo-Elezz, Mostafa Mehrez, Maaly M Mabrouk, Ola A Elshora
OBJECTIVES: Study of inflammatory biomarkers which may aid in early detection of ventilator-associated pneumonia (VAP) in children and predicting their outcome. PATIENTS: Thirty-five children, aged 2 months to 13 years, needed mechanical ventilation (MV) for more than 48 hours due to causes other than pneumonia. METHODS: Measurement of serum amyloid A (SAA) protein, soluble intercellular adhesion molecule 1 (sICAM-1), and C-reactive protein (CRP), modified clinical pulmonary infection score (CPIS) and performing culture of endotracheal aspirate at the start and on the third day of MV...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28395406/-expression-and-differential-diagnostic-value-of-serum-microrna-for-invasive-pulmonary-aspergillosis
#15
Z N Wen, Z G Ling, Y Huang, X Li
Objective: To explore the expression and the clinical diagnostic value of serum miR-21 for invasive pulmonary aspergillosis (IPA). Methods: Outpatients and inpatients from the Fourth Affiliated Hospital of Guangxi Medical University were included in the study during June 2014 to September 2015. The IPA group had 40 patients, male 22, female 18, aged 55-68 years (mean 60 ), while the control groups included 50 patients with pulmonary tuberculosis [male 23, female 27, aged 50-62 years (mean 55 )], 50 patients with lung cancer [male 30, female 20, aged 55-70 years (mean 62)], and 50 healthy controls [male 25, female 25, aged 50-67 years (mean 60) ]...
April 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28393009/a-case-of-anti-aminoacyl-trna-synthetase-ars-antibody-positive-polymyositis-pm-dermatomyositis-dm-associated-interstitial-pneumonia-ip-successfully-controlled-with-bosentan-therapy
#16
Tomoyuki Naito, Yosuke Tanaka, Mitsunori Hino, Akihiko Gemma
A 72-year-old woman was admitted to our hospital and was diagnosed with interstitial pneumonia (IP) associated with amyopathic dermatomyositis (ADM). The patient experienced three acute IP exacerbations in the 7 years that followed, which were each treated and resolved with steroid pulse therapy. The patient was closely examined for respiratory failure with right heart catheterization (RHC), which demonstrated that she had a mean pulmonary artery pressure (mPAP) of 34 mmHg. The patient was thus diagnosed as having pulmonary hypertension (PH) associated with anti-synthetase syndrome (ASS) and was started on bosentan therapy, which led to improvements in mPAP as well as in subjective symptoms over time...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28386192/study-of-lung-cancer-regulatory-network-that-involves-erbb4-and-tumor-marker-gene
#17
Xuhui Ma, Lu Li, Tongde Tian, Huaimin Liu, Qiujian Li, Qilong Gao
Our purpose is to screen out serum tumor markers closely correlated to the nature of solitary pulmonary nodule (SPN) and to draw a regulatory network containing genes correlated to lung cancer. Two hundred and sixty cases of SPN patients confirmed through pathological diagnosis were collected as subjects, factors closely correlated to the nature of SPN were screened out from eight tumor markers through Fisher discriminant method, and functional annotation and pathway analysis were conducted on erbB4 as well as its tumor marker genes by GO and KEGG databases...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28384354/sustained-elevated-levels-of-c-reactive-protein-and-ferritin-in-pulmonary-tuberculosis-patients-remaining-culture-positive-upon-treatment-initiation
#18
Pryscila Miranda, Leonardo Gil-Santana, Marina G Oliveira, Eliene D D Mesquita, Elisangela Silva, Anneloek Rauwerdink, Frank Cobelens, Martha M Oliveira, Bruno B Andrade, Afrânio Kritski
BACKGROUND: Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT)...
2017: PloS One
https://www.readbyqxmd.com/read/28383629/ip-10-in-occupational-asthma-review-of-the-literature-and-case-control-study
#19
F Ragusa, P Fallahi
OBJECTIVES: T-helper (Th)2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon (IFN)-γ-induced protein 10 (IP-10)/chemokine (C-X-C motif) ligand (CXCL)10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. Viral infection and allergens can exacerbate asthma by inducing the accumulation of these chemokines and inflammatory cells in the airway. Short-acting β2-adrenoreceptor agonists, budesonide and formoterol (all important relievers in asthma exacerbation), such as vitamin D3, vitamin C, have been shown to inhibit airway cells inflammatory responses by modulating these chemokines...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28366184/the-role-of-inflammatory-biomarkers-in-chd-associated-pulmonary-hypertension-in-children
#20
Gokcen Oz-Tuncer, Rana Olgunturk, Ayhan Pektas, Erman Cilsal, Serdar Kula, Deniz A Oguz, Sedef F Tunaoglu, Ozge T Pasaoglu, Hatice Pasaoglu
OBJECTIVE: The present study aims to identify the role of inflammatory markers such as C-reactive protein, interleukin-6, and fractalkine in CHD-associated pulmonary hypertension in children. METHODS: This is a prospective review of 37 children with CHD-related pulmonary hypertension, 21 children with congenital heart defects, and 22 healthy children. RESULTS: Serum C-reactive protein and interleukin-6 levels were significantly higher in the children with CHD-related pulmonary hypertension (respectively, p=0...
March 2017: Cardiology in the Young
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