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Stefan M Woerner, Elena Tosti, Yan P Yuan, Matthias Kloor, Peer Bork, Winfried Edelmann, Johannes Gebert
Different DNA mismatch repair (MMR)-deficient mouse strains have been developed as models for the inherited cancer predisposing Lynch syndrome. It is completely unresolved, whether coding mononucleotide repeat (cMNR) gene mutations in these mice can contribute to intestinal tumorigenesis and whether MMR-deficient mice are a suitable molecular model of human microsatellite instability (MSI)-associated intestinal tumorigenesis. A proof-of-principle study was performed to identify mouse cMNR-harboring genes affected by insertion/deletion mutations in MSI murine intestinal tumors...
November 2015: Molecular Carcinogenesis
Nancy J Nesslinger, Robert A Sahota, Brad Stone, Kayli Johnson, Navraj Chima, Caitlin King, Devon Rasmussen, Darcy Bishop, Paul S Rennie, Martin Gleave, Paul Blood, Howard Pai, Charles Ludgate, Brad H Nelson
PURPOSE: Prostate tumors express antigens that are recognized by the immune system in a significant proportion of patients; however, little is known about the effect of standard treatments on tumor-specific immunity. Radiation therapy induces expression of inflammatory and immune-stimulatory molecules, and neoadjuvant hormone therapy causes prominent T-cell infiltration of prostate tumors. We therefore hypothesized that radiation therapy and hormone therapy may initiate tumor-specific immune responses...
March 1, 2007: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Xiaolin Bi, Tamara Jones, Fatima Abbasi, Heuijung Lee, Brian Stultz, Deborah A Hursh, Mark A Mortin
We previously showed that the Drosophila DNA binding homeodomain of Prospero included a 28 amino-acid sequence (HDA) that functions as a nuclear export signal. We describe here the identification of a protein we named Caliban, which can directly interact with the HDA. Caliban is homologous to human Sdccag1, which has been implicated in colon and lung cancer. Here we show that Caliban and Sdccag1 are mediators of nuclear export in fly and human cells, as interference RNA abrogates export of EYFP-HDA in normal fly and human lung cells...
December 15, 2005: Oncogene
D Carbonnelle, T Liehr, C Jacquot, D Masson, P Lustenberger, M G Denis, C Roussakis
No abstract text is available yet for this article.
1999: Cytogenetics and Cell Genetics
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