Nancy J Nesslinger, Robert A Sahota, Brad Stone, Kayli Johnson, Navraj Chima, Caitlin King, Devon Rasmussen, Darcy Bishop, Paul S Rennie, Martin Gleave, Paul Blood, Howard Pai, Charles Ludgate, Brad H Nelson
PURPOSE: Prostate tumors express antigens that are recognized by the immune system in a significant proportion of patients; however, little is known about the effect of standard treatments on tumor-specific immunity. Radiation therapy induces expression of inflammatory and immune-stimulatory molecules, and neoadjuvant hormone therapy causes prominent T-cell infiltration of prostate tumors. We therefore hypothesized that radiation therapy and hormone therapy may initiate tumor-specific immune responses...
March 1, 2007: Clinical Cancer Research