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https://www.readbyqxmd.com/read/29913299/pharmacological-and-toxicological-study-of-a-chemical-standardized-ethanol-extract-of-the-branches-and-leaves-from-eysenhardtia-polystachya-ortega-sarg-fabaceae
#1
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913186/blockade-of-t-type-calcium-channels-by-6-prenylnaringenin-a-hop-component-alleviates-neuropathic-and-visceral-pain-in-mice
#2
Fumiko Sekiguchi, Tomoyo Fujita, Takahiro Deguchi, Sakura Yamaoka, Ken Tomochika, Maho Tsubota, Sumire Ono, Yamato Horaguchi, Maki Ichii, Mio Ichikawa, Yumiko Ueno, Nene Koike, Tadatoshi Tanino, Huy Du Nguyen, Takuya Okada, Hiroyuki Nishikawa, Shigeru Yoshida, Tsuyako Ohkubo, Naoki Toyooka, Kazuya Murata, Hideaki Matsuda, Atsufumi Kawabata
Since Cav 3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav 3.2 or Cav 3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0...
June 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29913059/quality-of-life-of-head-and-neck-cancer-patients-in-urban-and-regional-areas-an-australian-perspective
#3
Kelsey A Pateman, Nicole L Cockburn, Martin D Batstone, Pauline J Ford
OBJECTIVE: Head and neck cancer treatment affects quality of life. There are differences in quality of life outcomes and perceived supportive care needs between cancer patients living in metropolitan and regional-remote areas. This study investigated quality of life over the first 6 months following head and neck cancer diagnosis and observed differences in quality of life by geographical location. DESIGN: Prospective observational study. SETTING: Tertiary hospital in Brisbane, Australia...
June 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29912763/factors-associated-with-adenoma-detection-in-propofol-sedated-patients
#4
Hui Jia, Malcolm Koo, Yu-Hsi Hsieh, Chih-Wei Tseng, Chi-Tan Hu, Linhui Zhang, Tao Dong, Yanglin Pan, Felix W Leung
GOALS: To assess the factors associated with adenoma detection in propofol-sedated patients. BACKGROUNDS: Low adenoma detection rate (ADR) are linked to increased risk of interval cancer and related deaths. Compared with air insufflation (AI) colonoscopy, the method of water exchange (WE) significantly decreased insertion pain and increased ADR in unsedated patients. Deep sedation with propofol has been increasingly used in colonoscopy. One report suggested that WE significantly increased ADR in propofol-sedated patients, but the factors associated with adenoma detection were not analyzed...
June 15, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912607/reference-data-of-the-eortc-qlq-c30-questionnaire-five-consecutive-annual-assessments-of-approximately-2000-representative-dutch-men-and-women
#5
Floortje Mols, Olga Husson, Marije Oudejans, Carla Vlooswijk, Nicole Horevoorts, Lonneke V van de Poll-Franse
OBJECTIVE: Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. METHODS: The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333)...
June 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29912452/genetic-predictors-of-response-to-acupuncture-for-aromatase-inhibitor-associated-arthralgia-among-breast-cancer-survivors
#6
Timothy J Genovese, Jun J Mao
Objective: To evaluate the associations between polymorphisms in two genes, catechol-O-methyltransferase and T-cell leukemia/lymphoma 1 A, and acupuncture-mediated pain reduction among breast cancer survivors with aromatase inhibitor-associated arthralgia. Design, Setting, and Subjects: Biospecimens were obtained from 38 patients enrolled in a clinical trial of acupuncture for aromatase inhibitor-associated arthralgia in postmenopausal hormone receptor-positive breast cancer survivors...
April 17, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29912274/selective-ret-kinase-inhibition-for-patients-with-ret-altered-cancers
#7
V Subbiah, V Velcheti, B B Tuch, K Ebata, N L Busaidy, M E Cabanillas, L J Wirth, S Stock, S Smith, V Lauriault, S Corsi-Travali, D Henry, M Burkard, R Hamor, K Bouhana, S Winski, R D Wallace, D Hartley, S Rhodes, M Reddy, B J Brandhuber, S Andrews, S M Rothenberg, A Drilon
Purpose: Alterations involving the RET kinase are implicated in the pathogenesis of lung, thyroid and other cancers. However, the clinical activity of multikinase inhibitors with anti-RET activity in RET-altered patients appears limited, calling into question the therapeutic potential of targeting RET. LOXO-292 is a selective RET inhibitor designed inhibit diverse RET fusions, activating mutations and acquired resistance mutations. Patients and Methods: Potent anti-RET activity, high selectivity, and central nervous system coverage were confirmed preclinically using a variety of in vitro and in vivo RET-dependent tumor models...
April 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29911992/motivational-valence-is-determined-by-striatal-melanocortin-4-receptors
#8
Anna Mathia Klawonn, Michael Fritz, Anna Nilsson, Jordi Bonaventura, Kiseko Shionoya, Elahe Mirrasekhian, Urban Karlsson, Maarit Jaarola, Björn Granseth, Anders Blomqvist, Michael Michaelides, David Engblom
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and aversion. Aversive signaling causes extensive suffering during chronic diseases, including inflammatory conditions, cancer, and depression. Here, we investigated the role of melanocortin 4 receptors (MC4Rs) in aversive processing using genetically modified mice and a behavioral test in which mice avoid an environment that they have learned to associate with aversive stimuli...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29911652/building-the-evidence-for-crps-research-from-a-lived-experience-perspective
#9
Colleen M Johnston, Florin I Oprescu, Marion Gray
Background and aims Pain is known to be a subjective experience yet the majority of pain related research does not address the lived experience of the condition. Difficult to diagnose, Complex Regional Pain Syndrome (CRPS) is often poorly managed. The aim of this paper was to identify and synthesise the currently available literature on experiences of living with chronic pain in order to understand where and how CRPS research may be best situated in the future. Methods A narrative review was performed and ProQuest, EBSCO, Informit, Scopus/Science Direct and Web of Science, Medline, CINHAL and Google Scholar were searched in order to identify the literature from 1998 until 2015...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911634/blockage-of-lysophosphatidic-acid-reverses-arthritis-induced-hypersensitivity-and-cav%C3%AE-2%C3%AE-1-and-p2x3-expression-in-dorsal-root-ganglia
#10
J Su, A Delaney, R Matteo, B Bartlett, K Kultima, T Hökfelt, C I Svensson
Aims The lysophosphatidic acid (LPA) is an important mediator involved in neuropathic and bone cancer pain models. We are investigating if LPA is involved in arthritis-induced pain in the collagen antibody-induced arthritis (CAIA) mice model. Methods Arthritis was induced in male CBA mice by injection of 1.5 mg collagen type II antibody cocktail. Mechanical and thermal sensitivity and the degree of arthritis were assessed with von Frey filaments, Hargreaves box (heat), acetone test (cold) and visual scoring, respectively...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910853/body-mass-index-low-cir-in-colonoscopy
#11
Adnan Qureshi, Saira BiBi, Ravi Madhotra
Aim: The aim of this study was to determine common factors leading to incomplete colonoscopy with a special interest in patient body mass index (BMI), and also to determine most common second line investigation, its pick up rates for cancer and the success rate of re-scoping. Background: Wide availability of scope guide in all procedures may decrease failure rate. Methods: We retrospectively reviewed 2891 colonoscopies performed at our institution from August 2015 to July 2016...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29910637/combined-microwave-ablation-and-minimally-invasive-open-decompression-for-the-management-of-thoracic-metastasis-in-breast-cancer
#12
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29910634/is-preoperative-hypocholesterolemia-a-risk-factor-for-severe-postoperative-pain-analysis-of-1-944-patients-after-laparoscopic-colorectal-cancer-surgery
#13
Tak Kyu Oh, Sung-Bum Kang, In-Ae Song, Jung-Won Hwang, Sang-Hwan Do, Jin Hee Kim, Ah-Young Oh
Purpose: This study aimed to identify the effect of preoperative serum total cholesterol on postoperative pain outcome in patients who had undergone laparoscopic colorectal cancer surgery. Methods: We retrospectively reviewed the medical records of patients diagnosed with colorectal cancer who had undergone laparoscopic colorectal surgery from January 1, 2011, to June 30, 2017, to identify the relationship of total cholesterol levels within a month prior to surgery with the numeric rating scale (NRS) scores and total opioid consumption on postoperative days (PODs) 0-2...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29909565/topical-pimecrolimus-versus-betamethasone-for-oral-lichen-planus-a-randomized-clinical-trial
#14
Ola M Ezzatt, Iman M Helmy
OBJECTIVES: Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiation in head and neck carcinomas. We compared short-term clinical effectiveness of topical pimecrolimus as selective inflammatory cytokine release inhibitor with betamethasone cream for erosive/atrophic OLP and investigated the influence of this therapy on CD133 expression. MATERIAL AND METHODS: Thirty patients were randomly assigned into two equal groups to receive topical pimecrolimus (group I) or betamethasone (group II) four times daily for 4 weeks...
June 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29909203/neuronal-complement-cascade-drives-bone-cancer-pain-via-c3r-mediated-microglial-activation
#15
Xiaoxia Huang, Jinyuan Li, Jin Xie, Yang Li, Yan Gao, Xiaohui Li, Xueqin Xu, Ruoshi Shi, Wanjun Yao, Changbin Ke
Activation of spinal cord microglia is crucial for the development of bone cancer pain (BCP). The essential signal between neuronal excitability and microglial activation is not fully understood. In the present study, carcinoma implantation into tibia was used to induce BCP and RNAi-lentivirus was injected into spinal cord to knock down C1, C2 or C3 of complement cascade. We showed that C1, C2 and C3 co-localized in the same neurons and increased in cancer-bearing rats along with microglial activation. Knocked down of C1, C2 or C3 inhibited microglial activation and prevented the development of cancer-induced bone pain...
June 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29909057/study-design-and-protocol-for-a-culturally-adapted-cognitive-behavioral-stress-and-self-management-intervention-for-localized-prostate-cancer-the-encuentros-de-salud-study
#16
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29908526/case-reports-of-five-cancer-patients-with-unusual-course
#17
Dietmar Payrhuber, Karin Thieves, Piero Sangaletti, Josef Muehlmann, Michael Frass
INTRODUCTION:  The analysis of the periodic table of elements by Jan Scholten opened the way for a new kind of classification and repertorisation of homeopathic remedies. Thereby, group analysis (resorting to series and stages) makes precise prescriptions possible. This approach appears to yield striking results, even in severe cases. Whereas Hahnemann stressed the emotional state ('Gemüthssymptome', Organon § 210) when choosing a remedy, Scholten 200 years later investigated the mental picture that represents a life conflict or even a life theme that may maintain the disease process...
June 16, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29907086/potential-risk-factors-and-prevalence-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-symptoms-in-cameroon
#18
Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga, Hubert Leundji
BACKGROUND: Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought to determine potential risk factors associated with seroprevalence of H. pylori among dyspepsia patients in Cameroon for a better management of the disease. METHODS: The study was carried out from August to December 2014 at Laquintinie Hospital and District Hospital of Bonassama in Douala metropolis...
June 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29906764/end-of-life-healthcare-expenditure-testing-economic-explanations-using-a-discrete-choice-experiment
#19
Barbara Fischer, Harry Telser, Peter Zweifel
Healthcare expenditure (HCE) spent during an individual's last year of life accounts for a high share of lifetime HCE. This finding is puzzling because an investment in health is unlikely to have a sufficiently long payback period. However, Becker et al. (2007) and Philipson et al. (2010) have advanced a theory designed to explain high willingness to pay (WTP) for an extension of life close to its end. Their testable implications are complemented by the concept of 'pain of risk bearing' introduced by Eeckhoudt and Schlesinger (2006)...
June 7, 2018: Journal of Health Economics
https://www.readbyqxmd.com/read/29906316/interventions-for-the-reduction-of-prescribed-opioid-use-in-chronic-non-cancer-pain
#20
REVIEW
Phyllis B Whitehead
No abstract text is available yet for this article.
June 2018: Research in Nursing & Health
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