Read by QxMD icon Read

cancer pain

Ayako Tsuboya, Ken-Ichi Fujita, Yutaro Kubota, Hiroo Ishida, Iori Taki-Takemoto, Daisuke Kamei, Shinichi Iwai, Yasutsuna Sasaki
BACKGROUND: Cholinergic syndrome is an acute adverse event frequently observed in patients administered irinotecan, and can sometimes negatively affect their quality of life. In some manifestations of the syndrome such as bradycardia, careful monitoring of patients is advised. In this study, we retrospectively investigated the risk factors associated with irinotecan-induced cholinergic syndrome in Japanese patients with cancer. METHODS: Patients who received irinotecan-based chemotherapy between April 2014 and June 2018 were examined...
September 22, 2018: International Journal of Clinical Oncology
Shinsuke Kazama, Takeyuki Hiramatsu, Kenji Kuroda, Kumiko Hongo, Yukihiro Watanabe, Toshiaki Tanaka, Ken Kuriki
Intestinal endometriosis exposed to the mucosa is relatively rare. Therefore, its endoscopic findings with pit pattern and magnifying endoscopy with narrow-band imaging and clinicopathological features of intestinal endometriosis exposed to the mucosa have not been well documented until now. A 44-year-old woman was suspected to have gastrointestinal bleeding by positive fecal occult blood test. Colonoscopy revealed a hemicircular submucosal tumor whose surface was covered with easy-bleeding papillary bulges in the rectum...
September 22, 2018: Clinical Journal of Gastroenterology
Yue Hao, Xinxin Luo, Xiyuan Ba, Jiali Wang, Shiyang Zhou, Shimin Yang, Changji Fang, Changyu Jiang, Wuping Sun
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a major dose- and therapy-limiting side effect that is particularly difficult to treat. Huachansu, an aqueous extract from toad skin, is a widely used anti-cancer natural product in China. Clinical findings have established the safety and effectiveness of Huachansu in combination with chemotherapy to promote the therapeutic efficacy while alleviate the side effects, especially cancer-related pain symptoms. Unfortunately, experimental data on the effects and mechanisms of Huachansu in combination with chemotherapy is not available...
September 20, 2018: Gene
Tao Yan, Guo-Hua Zhang, Bao-Na Wang, Li Sun, Hui Zheng
BACKGROUND: Vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) have been involved in tumor growth and metastasis. Sevoflurane may promote angiogenesis, whereas propofol can present an anti-angiogenic effect. In this study, we compared the effects of propofol/remifentanil-based total intravenous anesthesia (TIVA) and sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β, as well as recurrence- free survival (RFS) rates in the patients undergoing breast cancer surgery...
September 22, 2018: BMC Anesthesiology
Katie Wang, Caitlin Yee, Samantha Tam, Leah Drost, Stephanie Chan, Pearl Zaki, Victoria Rico, Krista Ariello, Mark Dasios, Henry Lam, Carlo DeAngelis, Edward Chow
PURPOSE: To evaluate the prevalence and severity of persistent pain after breast cancer treatment (PPBCT) in patients who received surgery, radiotherapy or a combination of treatments and to explore how different treatments and techniques impact pain. METHODS: Medline, Embase and Cochrane Central databases were searched for articles which evaluated the prevalence of PPBCT. Search results were limited to studies addressing chronic post-surgical pain (CPSP), persistent post-surgical pain (PPSP), post-mastectomy pain syndrome (PMPS) or radiotherapy (RT) related pain in breast cancer patients and published in the English language...
September 4, 2018: Breast: Official Journal of the European Society of Mastology
Sam H Ahmedzai, Mary Jocylyn Bautista, Kamel Bouzid, Rachel Gibson, Yuddi Gumara, Azza Adel Ibrahim Hassan, Seiji Hattori, Dorothy Keefe, Durval Campos Kraychete, Dae Ho Lee, Kazuo Tamura, Jie Jun Wang
PURPOSE: Adequate cancer pain management (CPM) is challenging in resource-limited settings, where current international guideline recommendations are difficult to implement owing to constraints such as inadequate availability and accessibility of opioids, limited awareness of appropriate opioid use among patients and clinicians, and lack of guidance on how to translate the best evidence into clinical practice. The multinational and multidisciplinary CAncer Pain managEment in Resource-limited settings (CAPER) Working Group proposes a two-step initiative to bridge clinical practice gaps in CPM in resource-limited settings...
September 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
W Häuser, T Schubert, N Scherbaum, T Tölle
BACKGROUND: One major concern of long-term opioid therapy (LTOT) for chronic noncancer pain (CNCP) is the risk of abuse of prescribed opioids. OBJECTIVE: To examine the prevalence and predictors of opioid use-related hospitalizations and potential abuse of prescribed opioids by persons with LTOT for CNCP in a sample representative of the German statutory health insurance companies. METHODS: Retrospective cross-sectional study in 2014. Anonymized German health claims database, including 4,028,618 insured individuals of 69 German statutory health insurances...
September 21, 2018: Der Schmerz
Amit H Sachdev, Frank G Gress
Pain is often associated with chronic pancreatitis and pancreatic cancer. Often times opioids are used to treat pain; however, the use of opioids is frequently difficult. Endoscopic ultrasound-guided celiac plexus block and celiac plexus nuerolysis are safe and effective modalities used to alleviate pain. Celiac plexus block is a transient interruption of the plexus by local anesthetic, while celiac plexus neurolysis is prolonged interruption of the transmission of pain from the celiac plexus using chemical ablation...
October 2018: Gastrointestinal Endoscopy Clinics of North America
Dang Huy Quoc Thinh, Wimonrat Sriraj, Marzida Mansor, Kian Hian Tan, Cosphiadi Irawan, Johan Kurnianda, Yen Phi Nguyen, Annielyn Ong-Cornel, Yacine Hadjiat, Hanlim Moon, Francis O Javier
PURPOSE: To identify patterns of analgesic prescription and to explore patient-reported pain intensity, sleep disturbance, and quality of life among cancer patients with pain in Southeast Asia (SEA). METHODS: This cross-sectional observational study included 465 adult outpatients prescribed analgesics for cancer pain for 1 month or longer at 22 sites in Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam. Data on analgesic prescription and cancer characteristics were extracted from medical records...
September 2018: Journal of Global Oncology
Katherine E Doyle, Shatha K El Nakib, M R Rajagopal, Sunil Babu, Geeta Joshi, Vidya Kumarasamy, D Priya Kumari, Prabir Chaudhuri, Sumita Mohanthy, Debasish Jatua, Diederik Lohman, Joseph J Amon, Gayatri Palat
PURPOSE: More than 1 million new occurrences of cancer are diagnosed in India annually. Among patients with cancer, pain is a common and persistent symptom of the disease and its treatment. However, few studies to date have evaluated the prevalence of pain and the adequacy of pain management in Indian hospitals. This cross-sectional study aimed to assess the prevalence and sociodemographic patterns of cancer pain and pain management among a sample of inpatients and newly registered outpatients at four large regional cancer centers in India...
September 2018: Journal of Global Oncology
Stephanie B Wheeler, Jennifer Spencer, Laura C Pinheiro, Caitlin C Murphy, Jo Anne Earp, Lisa Carey, Andrew Olshan, Chiu Kit Tse, Mary E Bell, Morris Weinberger, Katherine E Reeder-Hayes
Background: Differential use of endocrine therapy (ET) by race may contribute to breast cancer outcome disparities, but racial differences in ET behaviors are poorly understood. Methods: Women aged 20-74 years with a first primary, stage I-III, hormone receptor-positive (HR+) breast cancer were included. At 2 years postdiagnosis, we assessed nonadherence, defined as not taking ET every day or missing more than two pills in the past 14 days, discontinuation, and a composite measure of underuse, defined as either missing pills or discontinuing completely...
September 20, 2018: Journal of the National Cancer Institute
Ros Idayu Mat Nawi, Ping Lei Chui, Wan Zamaniah Wan Ishak, Caryn Mei Hsien Chan
BACKGROUND: Evidence remains mixed on the benefits of oral cryotherapy in the prevention of oral mucositis and pain associated with fluorouracil-based chemotherapy. OBJECTIVES: The intent of this article is to evaluate the effect of oral cryotherapy on the prevention of oral mucositis and pain among patients with colorectal cancer undergoing fluorouracil-based chemotherapy. METHODS: Using an experimental study design, the authors randomly assigned 80 patients to either the intervention (n = 40) or usual care group (n = 40)...
October 1, 2018: Clinical Journal of Oncology Nursing
Tonje A Sande, Barry J A Laird, Marie T Fallon
BACKGROUND: Opioids are the foundation of treatment for cancer pain but can cause side-effects, one of the most common being nausea and vomiting, which can impair quality of life. OBJECTIVE: To evaluate the evidence for the management of opioid-induced nausea and vomiting. This systematic review was undertaken as part of an update of the European Association for Palliative Care's opioid guidelines. DESIGN: Searches of MEDLINE (1966-2017) and EMBASE (1980-2017) were done...
September 21, 2018: Journal of Palliative Medicine
Min Chen, Huishu Yuan
We report the case of a 54-year-old man with 6 months of progressive sacral pain. Computed tomography showed a large osteolytic mass in the sacrum with multiple osteolytic foci in the ilium and lumbar spine. Magnetic resonance imaging revealed multiple fluid-fluid levels in the sacral lesion as well as in the lumbar foci. The multiple bone lesions were initially diagnosed as a primary sacral malignancy with multiple bone metastases. A biopsy of the sacral lesion under the guidance of computed tomography was performed and a metastatic adenocarcinoma from the stomach or lung was found pathologically...
September 20, 2018: Skeletal Radiology
Gary W Jay, Robert L Barkin
Patients experiencing a terminal drug related event reflect a sentinel event. If this pharmacotherapy is a widely used agent, it may be viewed as a catastrophic problem. If patients are dying from illegal drug use when the medical establishment fails them by withdrawing or minimizing their medically prescribed medication, then the burden rests with their health care providers, legislation, and insurance carriers to actively participate in a collegial fashion to achieve parity. Causing a decay in functionality in previously functional patients, may occur with appropriately prescribed opioid medications addressing non-cancer pain when withdrawing or diminishing either with or without patient consent...
September 18, 2018: Disease-a-month: DM
Weranja Ranasinghe, Daswin de Silva, Tharindu Bandaragoda, Achini Adikari, Damminda Alahakoon, Raj Persad, Nathan Lawrentschuk, Damien Bolton
BACKGROUND: The advantages of Robot-assisted laparoscopic prostatectomy (RARP) over open radical prostatectomy (ORP) in Prostate cancer perioperatively are well-established, but quality of life is more contentious. Increasingly, patients are utilising online cancer support groups (OCSG) to express themselves. Currently there is no method of analysis of these sophisticated data sources. We have used the PRIME-2 (Patient Reported Information Multidimensional Exploration version 2) framework for automated identification and intelligent analysis of decision-making, functional and emotional outcomes in men undergoing ORP vs...
September 17, 2018: Urologic Oncology
Jean-Jacques Body, Roger von Moos, Daniela Niepel, Bertrand Tombal
BACKGROUND: Most patients with advanced prostate cancer develop bone metastases, which often result in painful and debilitating skeletal-related events. Inhibitors of bone resorption, such as bisphosphonates and denosumab, can each reduce the incidence of skeletal-related events and delay the progression of bone pain. However, these agents are associated with an increased risk of hypocalcaemia, which, although often mild and transient, can be serious and life-threatening. Here we provide practical advice on managing the risk of hypocalcaemia in patients with advanced prostate cancer who are receiving treatment with bone resorption inhibitors...
September 20, 2018: BMC Urology
Ningning Li, Weixun Zhou, Lin Zhao, Jiaolin Zhou
BACKGROUND: Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of endometriosis underwent surgery for malignant intestinal endometriosis. CASE PRESENTATION: A 55-year-old woman complained of rectorrhagia and intermittent abdominal pain. A neoplasm was revealed by colonoscopy, CT scan and F18-FDG PET/CT of the recto-sigmoidal colon...
September 20, 2018: BMC Cancer
Gun Min Kim, Joo Hoon Kim, Ji Heung Jeong, Young Up Cho, Seung Il Kim, Seho Park, Hyung Seok Park, Ji Ye Kim, Joohyuk Sohn
Purpose: Dose-dense chemotherapy (DD-CT) is a preferred (neo) adjuvant regimen in early breast cancer (BC). Although the results of reported randomized trials are conflicting, a recent meta-analysis showed improved overall and disease-free survival with DD-CT compared to conventional schedules. However, no DD-CT safety data for Korean BC patients are available. This phase II study was conducted to evaluate the safety and efficacy of pegteograstim in Korean BC patients receiving DD-CT...
September 19, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Yunfeng Jiang, Junhong Li, Huasheng Lin, Qiaotong Huang, Tongbiao Wang, Shijie Zhang, Qing Zhang, Zheng Rong, Jun Xiong
BACKGROUND: The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery. METHODS: In November 2017, a systematic computer-based search was conducted in PubMed, Embase, Web of Science, Cochrane Library, and Google databases. RCTs comparing gabapentin with placebo in patients undergoing breast cancer surgery were retrieved...
September 2018: Medicine (Baltimore)
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"