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https://www.readbyqxmd.com/read/29166684/-implantation-of-a-modular-distal-femoral-replacement-with-compressive-osseointegration-as-a-salvage-procedure-in-a-complex-femoral-posttraumatic-setting
#1
Anna Janine Schreiner, Peter Marten de Zwart, Christian Arnscheidt, Ulrich Stöckle, Björn Gunnar Ochs
Background Large bone defects and losses play a crucial role in both tumour surgery and in complex primary and revision total knee replacement. The established options of cemented or uncemented long intramedullary stems are limited by large bone defects and are at risk from relatively high exposure to aseptic loosening. There is no general valid agreement on implant fixation of the distal femur. A further option is the cementless fixation method with compressive osseointegration, based on the so-called Wolff law of bone remodelling...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29163452/the-opportunistic-pathogen-vibrio-vulnificus-produces-outer-membrane-vesicles-in-a-spatially-distinct-manner-related-to-capsular-polysaccharide
#2
Cheri M Hampton, Ricardo C Guerrero-Ferreira, Rachel E Storms, Jeannette V Taylor, Hong Yi, Paul A Gulig, Elizabeth R Wright
Vibrio vulnificus, a bacterial species that inhabits brackish waters, is an opportunistic pathogen of humans. V. vulnificus infections can cause acute gastroenteritis, invasive septicemia, tissue necrosis, and potentially death. Virulence factors associated with V. vulnificus include the capsular polysaccharide (CPS), lipopolysaccharide, flagellum, pili, and outer membrane vesicles (OMVs). The aims of this study were to characterize the morphology of V. vulnificus cells and the formation and arrangement of OMVs using cryo-electron microscopy (cryo-EM)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162873/rapid-in-situ-imaging-and-whole-genome-sequencing-of-biofilm-in-neonatal-feeding-tubes-a-clinical-proof-of-concept
#3
Pauline Ogrodzki, Chi Shing Cheung, Mohamed Saad, Khaled Dahmani, Rebecca Coxill, Haida Liang, Stephen J Forsythe
The bacterial flora of nasogastric feeding tubes and faecal samples were analysed for a low-birth weight (725 g) neonate EGA 25 weeks in intensive care. Samples were collected at age 6 and 8 weeks of life. Optical coherence tomography (OCT) was used to visualise bacterial biofilms inside the nasogastric feeding tubes. The biofilm was heterogeneously distributed along the tube lumen wall, and had a depth of up to 500 µm. The bacterial biofilm and faecal samples included Enterococcus faecalis and Enterobacter hormaechei...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162713/capsular-polysaccharide-interferes-with-biofilm-formation-by-pasteurella-multocida-serogroup-a
#4
Briana Petruzzi, Robert E Briggs, W Edward Swords, Cristina De Castro, Antonio Molinaro, Thomas J Inzana
Pasteurella multocida is an important multihost animal and zoonotic pathogen that is capable of causing respiratory and multisystemic diseases, bacteremia, and bite wound infections. The glycosaminoglycan capsule of P. multocida is an essential virulence factor that protects the bacterium from host defenses. However, chronic infections (such as swine atrophic rhinitis and the carrier state in birds and other animals) may be associated with biofilm formation, which has not been characterized in P. multocida Biofilm formation by clinical isolates was inversely related to capsule production and was confirmed with capsule-deficient mutants of highly encapsulated strains...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29158721/knowledge-of-community-pharmacists-about-the-risks-of-medication-use-during-pregnancy-in-central-region-of-saudi-arabia
#5
Ziyad Alrabiah, Mohamed N Al-Arifi, Sultan M Alghadeer, Syed Wajid, Ali AlQahtani, Naif Almotari, AbdAllh AlHwerani, Salmeen D Babelghaith
Background: Community pharmacists (CPs) are the most accessible health care provider to the public, and they have huge duties to improve medication use especially among the pregnant women in their community. The objective of this study was to evaluate knowledge of CPs about the medication safety during pregnancy. Methods: A prospective cross-sectional survey was carried out over practicing community pharmacists in a capital of Saudi Arabia (SA). Pharmacists were asked about the safety of each medicine during pregnancy...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29157964/new-insights-on-the-influence-of-manufacturing-conditions-and-molecular-weight-on-phase-separated-films-intended-for-controlled-release
#6
Helene Andersson Moore, Mariagrazia Marucci, Linda Härdelin, Johan Hjärtstam, Mats Stading, Christian von Corswant, Anette Larsson
he aim of this work was to investigate how manufacturing conditions influence phase-separated films of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) with different molecular weights of HPC. Two HPC grades, SSL and M, with weight average molecular weights (Mw) of 30×10(3)g/mol and 365×10(3)g/mol, respectively, were combined with EC 10 cps (70:30w/w EC/HPC) and spray-coated from ethanol solutions onto a rotating drum under well-controlled process conditions. Generally, a low spray rate resulted in a more rapid film drying process and, consequently, in smaller HPC-rich domains in the phase-separated film structure...
November 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29155575/temporal-trends-of-c8-c36-chlorinated-paraffins-in-swedish-coastal-sediment-cores-over-the-past-80-years
#7
Bo Yuan, Volker Brüchert, Anna Sobek, Cynthia A de Wit
Temporal trends of chlorinated paraffins (CPs) were analyzed in three sediment cores collected near different potential CP sources along the Swedish Baltic Sea coast. C8-C36 CPs were found in sediment dating back to the 1930s. The maximum CP concentrations found in proximity to a metropolitan sewage treatment plant, a wood-related industrial area, and a steel factory were 48, 160, and 1400 ng/g d.w., respectively, in sediment sections dated from the early 1990s or the 2000s. The temporal trends agree with statistics on CP importation in Sweden or local industrial activities...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149070/placement-stability-cumulative-time-in-care-and-permanency-using-administrative-data-from-cps-to-track-placement-trajectories
#8
Sonia Hélie, Marie-Andrée Poirier, Tonino Esposito, Daniel Turcotte
Objectives: The Quebec Youth Protection Act was amended in 2007. The main goal of this reform was to improve placement stability for children who are removed from their home for their protection. Among several legal provisions introduced was the establishment of maximum age-specific durations of out-of-home care, after which a plan must be established to provide stability for children placed in substitute care by finding permanent homes for them. The purpose of this study is (1) to examine trends in placement use and placement stability since the reform and (2) to document the current frequency of each type of placement setting, the cumulative time in care before the exit to permanency, and the sustainability of the permanency outcome...
November 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29142773/suprasellar-and-third-ventricular-cavernous-malformation-lessons-learned-in-differential-diagnosis-and-surgical-planning
#9
Kay O Kulason, Julia R Schneider, Ralph Rahme, Fanni Ratzon, Todd A Anderson, Deborah R Shatzkes, Christopher G Filippi, Peter D Costantino, David J Langer, John A Boockvar
Background: While craniopharyngiomas (CPs) are the most common cystic suprasellar lesions in adults, cavernous malformations (CMs) only exceptionally occur in this location and are seldom considered in the differential diagnosis of such lesions. However, unlike CPs, suprasellar CMs are not typically approached via an endoscopic endonasal approach. Case Description: We present a unique clinical case of suprasellar and third ventricular CM mimicking a CP, posing a major decision-making dilemma at the levels of both preoperative diagnosis and surgical planning...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29138154/pharmacologic-management-of-chronic-neuropathic-pain-review-of-the-canadian-pain-society-consensus-statement
#10
REVIEW
Alex Mu, Erica Weinberg, Dwight E Moulin, Hance Clarke
OBJECTIVE: To provide family physicians with a practical clinical summary of the Canadian Pain Society (CPS) revised consensus statement on the pharmacologic management of neuropathic pain. QUALITY OF EVIDENCE: A multidisciplinary interest group within the CPS conducted a systematic review of the literature on the current treatments of neuropathic pain in drafting the revised consensus statement. MAIN MESSAGE: Gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors are the first-line agents for treating neuropathic pain...
November 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29138072/preoperative-assessment-of-craniopharyngioma-adherence-mri-findings-correlated-with-the-severity-of-tumor-attachment-to-the-hypothalamus
#11
Ruth Prieto, José M Pascual, Maria Rosdolsky, Laura Barrios
BACKGROUND: Craniopharyngioma (CP) adherence represents a heterogeneous pathological feature that critically influences the potentially safe and radical resection. OBJECTIVE: To define the MRI predictors of CP adherence severity. METHODS: This study retrospectively investigated a cohort of 200 surgically treated CPs with their corresponding preoperative conventional MRI scans. MRI findings related to the distortions of anatomical structures along the sella turcica-third ventricle axis caused by CPs, in addition to the tumor's shape and calcifications were analyzed and correlated with the definitive type of CP adherence observed during the surgical procedures...
November 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29137744/luminescence-electrochemical-and-photocatalytic-properties-of-sub-micron-nickel-ii-and-cobalt-ii-coordination-polymers-synthesized-by-sonochemical-process
#12
Jun Xuan Li, Yu Feng Li, Li Wei Liu, Guang Hua Cui
Submicron structures of Ni(II)/Co(II)-based coordination polymers (CPs) [Ni(L1)(mip)·H2O]n (1) and {[Co(L2)(mip)]·0·.5H2O}n(2) (L1=1,6-bis(5,6-dimethylbenzimidazole)hexane, L2=1,6-bis(benzimidazole)hexane, H2mip=5-methylisophthalic acid) were obtained by ultrasonic irradiation and structurally characterized by elemental analysis, powder X-ray diffraction and scanning electron microscopy. Structural analysis show that two CPs feature uninodal 3-connected 2D hcb layer, whilst CP 2 is further extended into a 3D complicated supramolecular network by C14-H14⋯O2 hydrogen bonds...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137277/ningnanmycin-inhibits-tobacco-mosaic-virus-virulence-by-binding-directly-to-its-coat-protein-discs
#13
Xiangyang Li, Gefei Hao, Qingmin Wang, Zhuo Chen, Yan Ding, Lu Yu, Deyu Hu, Baoan Song
Tobacco mosaic virus (TMV) causes severe plant diseases worldwide; however, effective antiviral agents for controlling TMV infections are not available. This lack of effective antiviral agents is mainly due to the poor understanding of potential targets associated with TMV infections. During infection, the coat protein (CP), which is delivered by viral particles into susceptible host cells, provides protection for viral RNA. Here, we found that Ningnanmycin (NNM), a commercially used plant antibacterial agent, inhibits the assembly of the CP by directly binding several residues...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136560/cytoprotective-effects-of-glycyrrhetinic-acid-liposome-against-cyclophosphamide-induced-cystitis-through-inhibiting-inflammatory-stress
#14
Bo Ge, Daping Yang, Xinmou Wu, Jing Zhu, Wu Wei, Bin Yang
This study was designed to investigate the pharmacological efficacy of glycyrrhetinic acid liposome (GAL) against female mice with nonbacterial cystitis induced by cyclophosphamide (CPS). Mice in different groups were subjected to tests for lactate dehydrogenase (LD), cytokine contents (IL-6, TNF-α) in serum, and histological changes in bladder tissue and to immunoassays. As a result, cyclophosphamide-induced cystitis in mice showed an increased LD level in serum, and the contents of cytokines (IL-6, TNF-α) were elevated...
November 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29136329/follow-up-of-sustained-virologic-responders-with-hepatitis-c-and-advanced-liver-disease-after-interferon-ribavirin-free-treatment
#15
Karin Kozbial, Stephan Moser, Ramona Al-Zoairy, Remy Schwarzer, Christian Datz, Rudolf Stauber, Hermann Laferl, Michael Strasser, Sandra Beinhardt, Albert Friedrich Stättermayer, Michael Gschwantler, Heinz Zoller, Andreas Maieron, Ivo Graziadei, Michael Trauner, Petra Steindl-Munda, Harald Hofer, Peter Ferenci
BACKGROUND: The introduction of direct-acting antivirals (DAA) has increased sustained virological response (SVR) rates in patients with advanced liver disease and chronic hepatitis C(CHC)infection. At present, data on clinical outcome and long-term durability of viral eradication after successful DAA therapy are scarce. AIM: To evaluate the long-term success of viral eradication in patients with advanced fibrosis or cirrhosis treated with DAAs. METHODS: Five hundred and fifty one patients with advanced fibrosis (n=158) or liver cirrhosis (CPS-A:317,CPS-B/C:76) and SVR after interferon and ribavirin-free DAA therapy treated between October 2013 and April 2016 were studied with a median follow-up of 65...
November 14, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29136076/enhancing-the-photostability-of-poly-phenylene-ethynylene-for-single-particle-studies
#16
C F Calver, B A Lago, K S Schanze, G Cosa
Single molecule fluorescence (SMF) studies on conjugated polymers yield enhanced information on exciton dynamics and on the interplay between polymer conformation/morphology and photophysical behavior. SMF studies, however, demand good signal stability, excellent photostability, and high photon yields (a measure of both photostability and brightness) and thus the development of strategies to help conjugated polymers (CPs) meet these requirements is a topic of great interest. Here, we evaluate the effect of a number of triplet quencher additives on the photostability of a 49-mer long poly(phenylene-ethynylene) conjugated polymer bearing carboxylate side groups (PPE-CO2-49) that is deposited onto 100 nm diameter SiO2 nanoparticles (NPs)...
November 14, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29131509/emission-tuning-with-size-controllable-polymer-dots-from-a-single-conjugated-polymer
#17
Jongho Kim, Taek Seung Lee
Two conjugated polymers (CPs) with various compositions of phenylene and benzoselenadiazoben (BSD) are synthesized to have a special emitting property; different fluorescence colors in solution and in the solid states, allowing the resulting conjugated polymer dots (Pdots) to emit different fluorescence colors upon their size variation. The photophysical property of such different-sized Pdots is investigated using fluorescence spectra and fluorescence lifetimes. A decrease in the fluorescence lifetime of Pdots is observed with an increase in the size of Pdots, caused by quantitative change in energy transfer from phenylene (energy donor) to the BSD unit (energy acceptor)...
November 13, 2017: Small
https://www.readbyqxmd.com/read/29126271/examining-the-transitions-between-cigarette-and-smokeless-tobacco-product-use-in-the-united-states-using-the-2002-2003-and-2010-2011-longitudinal-cohorts
#18
Joanne T Chang, David T Levy, Rafael Meza
Introduction: Smokeless tobacco (SLT) use in the US has remained constant or even increased slightly in recent years, while smoking has continuously decreased. Characterization of transitions between tobacco products is critical to understand the reasons behind the continuing use of smokeless tobacco. Methods: Two longitudinal cohorts of Tobacco Use Supplement of the Current Population Survey (TUS-CPS), 2002-2003 (n=14,996) and 2010-2011 (n=18,226) were used to examine transitions between cigarette and SLT use over one-year periods...
November 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29125574/coordination-polymers-containing-1-3-phenylenebis-1h-1-2-4-triazol-1-yl-methanone-ligand-synthesis-and-%C3%AE%C2%B5-caprolactone-polymerization-behavior
#19
Nestor J Bello-Vieda, Ricardo A Murcia, Alvaro Muñoz-Castro, Mario A Macías, John J Hurtado
The reaction of isophthaloyl dichloride with 1H-1,2,4-triazole afforded the new ligand 1,3-phenylenebis(1,2,4-triazole-1-yl)methanone (1). A series of Co(II), Cu(II), Zn(II) and Ni(II) complexes were synthesized using 1 and then characterized by melting point analysis, elemental analysis, theoretical calculations, thermogravimetric analysis, X-ray powder diffraction, nuclear magnetic resonance, infrared and Raman spectroscopy. Experimental and computational studies predict the formation of coordination polymers (CPs)...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29120357/a-decentralized-compositional-framework-for-dependable-decision-process-in-self-managed-cyber-physical-systems
#20
Peng Zhou, Decheng Zuo, Kun-Mean Hou, Zhan Zhang
Cyber Physical Systems (CPSs) need to interact with the changeable environment under various interferences. To provide continuous and high quality services, a self-managed CPS should automatically reconstruct itself to adapt to these changes and recover from failures. Such dynamic adaptation behavior introduces systemic challenges for CPS design, advice evaluation and decision process arrangement. In this paper, a formal compositional framework is proposed to systematically improve the dependability of the decision process...
November 9, 2017: Sensors
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