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https://www.readbyqxmd.com/read/28437231/capsular-polysaccharide-types-and-virulence-related-traits-of-epidemic-kpc-producing-klebsiella-pneumoniae-isolates-in-a-chinese-university-hospital
#1
Yang Liu, Pan-Pan Liu, Lian-Hui Wang, Dan-Dan Wei, La-Gen Wan, Wei Zhang
Klebsiella pneumoniae is an important human pathogen associated with a variety of diseases and the prevalence of blaKPC carrying K. pneumoniae (KPC-Kp) is rapidly increasing. Capsule is an important virulence factor in K. pneumoniae. In this study, we determined to first systematically characterize capsular polysaccharide (CPS) and virulence traits in KPC-Kp strains. A total of 56 KPC-Kp isolates were recovered from clinical samples in a Chinese hospital, which were assigned to clonal lineages by multilocus sequence typing (MLST)...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28436218/the-ptr3-a-novel-instrument-for-studying-the-lifecycle-of-reactive-organic-carbon-in-the-atmosphere
#2
Martin Breitenlechner, Lukas Fischer, Markus Hainer, Martin Heinritzi, Joachim Curtius, Armin Hansel
We have developed and characterized the novel PTR3, a Proton Transfer Reaction Time-of-Flight mass spectrometer (PTR-ToF) using a new gas inlet and an innovative reaction chamber design. The reaction chamber consists of a tripole operated with RF voltages generating an electric field only in radial direction. An elevated electrical field is necessary to reduce clustering of primary hydronium (H3O(+)) and product ions with water molecules present in the sample gas. The axial movement of the ions is achieved by the sample gas flow only...
April 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28435909/self-assembled-particulate-psaa-as-vaccine-against-streptococcus-pneumoniae-infection
#3
Majela González-Miro, Laura Rodríguez-Noda, Mildrey Fariñas-Medina, Dagmar García-Rivera, Vicente Vérez-Bencomo, Bernd H A Rehm
Streptococcus pneumoniae is a human pathogen responsible for the majority of childhood pneumonia and media otitis cases worldwide. The diversity of its capsular polysaccharides (CPS) results in more than 91 serotypes of which at least 23 are virulent. Various CPS conjugated to immunogenic carrier proteins are currently licensed and provide protection against the infection caused by the respective serotypes but not against new and emerging virulent serotypes. In this study, we considered the conserved protein antigen PsaA, the pneumococcal surface adhesin A, in order to overcome the limitations of CPS antigens...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28431914/pain-trajectories-of-nursing-home-residents-nearing-death
#4
Genevieve N Thompson, Malcolm Doupe, R Colin Reid, Jennifer Baumbusch, Carole A Estabrooks
BACKGROUND/OBJECTIVES: Although examining point in time prevalence of pain among nursing home (NH) residents has value, there is a lack of evidence describing the actual changes (ie, trajectories) in pain that take place during their last 6 months of life. The main objective of this study is to describe the major pain trajectories experienced by NH residents during their last 6 months of life. DESIGN: Secondary analysis of Resident Assessment Instrument-Minimum Data Set (MDS) 2...
April 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28427651/ultrasonic-synthesis-of-two-nanostructured-cadmium-ii-coordination-supramolecular-polymers-solvent-influence-luminescence-and-photocatalytic-properties
#5
Shao Yun Hao, Xue Gang Ma, Guang Hua Cui
Two nanoparticles of cadmium(II) coordination polymers (CPs) formulated as [Cd(L)(DCTP)]n (1) and [Cd(L)2(DCTP)·2H2O]n (2) (L=1,2-bis(2-methylbenzimidazol-1-ylmethyl)benzene, H2DCTP=2,5-dichloroterephthalic acid) were prepared by the sonochemical approach in different solvents and characterized by elemental analysis, IR spectra, scanning electron microscopy (SEM), and powder X-ray diffraction. Structural determination reveals that CP 1 displays a 2D four-connected sql net layer, Whilst CP 2 exhibits a 1D "V"-like chain structure...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427635/sonochemical-synthesis-of-two-new-zinc-ii-1-10-phenanthroline-coordination-supramolecular-compounds-new-precursors-to-produce-nano-sized-zinc-ii-oxide
#6
Mohammad Jaafar Soltanian Fard, Payam Hayati, Azita Firoozadeh, Jan Janczak
Nanoparticles of two zinc(II) coordination supramolecule compounds (CSCs), [Zn(L)Cl2] (1) and [Zn(L)Br2] (2) L=1,10-phen=1,10-phenanthroline ligand, have been synthesized by use of a sonochemical process and characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) spectroscopy and elemental analyses. The single crystal X-ray data of compounds 1 and 2 imply that the Zn(+2) ions are four coordinated. Topological analysis shows that the compound 1 and 2 are new topology for net: 1,3M4-1...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28425925/evaluation-of-the-immunomodulatory-properties-of-streptococcus-suis-and-group-b-streptococcus-capsular-polysaccharides-on-the-humoral-response
#7
Cynthia Calzas, Morgan Taillardet, Insaf Salem Fourati, David Roy, Marcelo Gottschalk, Hugo Soudeyns, Thierry Defrance, Mariela Segura
Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against S. suis serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice...
April 20, 2017: Pathogens
https://www.readbyqxmd.com/read/28421299/compared-effects-of-calcium-and-sodium-polystyrene-sulfonate-on-mineral-and-bone-metabolism-and-volume-overload-in-pre-dialysis-patients-with-hyperkalemia
#8
Yosuke Nakayama, Kaoru Ueda, Sho-Ichi Yamagishi, Miki Sugiyama, Chika Yoshida, Yuka Kurokawa, Nao Nakamura, Tomofumi Moriyama, Goh Kodama, Tomohisa Minezaki, Sakuya Ito, Akiko Nagata, Kensei Taguchi, Junko Yano, Yusuke Kaida, Kazutaka Shibatomi, Kei Fukami
BACKGROUND: Hyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied. METHODS: In a randomized and crossover design, 20 pre-dialysis patients with hyperkalemia (>5 mmol/l) received either oral CPS or SPS therapy for 4 weeks...
April 18, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28419115/properties-of-the-cuticular-proteins-of-anopheles-gambiae-as-revealed-by-serial-extraction-of-adults
#9
Yihong Zhou, Majors J Badgett, Lynne Billard, John Hunter Bowen, Ron Orlando, Judith H Willis
How cuticular proteins (CPs) interact with chitin and with each other in the cuticle remains unresolved. We employed LC-MS/MS to identify CPs from 5-6 day-old adults of Anopheles gambiae released after serial extraction with PBS, EDTA, 2-8M urea, and SDS as well as those that remained unextracted. Results were compared to published data on time of transcript abundance, localization of proteins within structures and within the cuticle, as well as properties of individual proteins, length, pI, percent histidine, tyrosine, glutamine, and number of AAP[A/V/L] repeats...
2017: PloS One
https://www.readbyqxmd.com/read/28413919/examining-child-welfare-decisions-and-services-for-asian-canadian-versus-white-canadian-children-and-families-in-the-child-welfare-system
#10
Barbara Lee, Esme Fuller-Thomson, Barbara Fallon, Tara Black, Nico Trocmé
Using administrative child welfare data from the Ontario Child Abuse and Neglect Data System (OCANDS), this study compared the profiles of Asian-Canadian and White-Canadian children and families that experienced a case closure after an investigation instead of being transferred to ongoing child protection services (CPS). Child protection investigations involving Asian-Canadian and White-Canadian children and families that were transferred to ongoing CPS presented a different profile of case characteristics and caregiver and child clinical needs...
May 2017: Child Maltreatment
https://www.readbyqxmd.com/read/28412487/occurrence-homologue-patterns-and-source-apportionment-of-short-%C3%A2-and-medium-chain-chlorinated-paraffins-in-suburban-soils-of-shanghai-china
#11
Xue-Tong Wang, Si-Yue Xu, Xi-Kui Wang, Bao-Ping Hu, Hao-Hao Jia
In order to systematically investigate the spatial distribution, homologue profiles, and sources of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in suburban soils in Shanghai, SCCPs and MCCPs in soils were analyzed using gas chromatography coupled with low resolution mass spectrometry in electron capture negative ion (ECNI) mode (GC-ECNI-MS). The CP concentrations in soils were between not detected (ND) - 697 ng g(-1) with a median value of 3.52 ng g(-1) for SCCPs, and ND - 666 ng g(-1) with a median value of 15...
April 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28412074/reversible-synthesis-of-colanic-acid-and-o-antigen-polysaccharides-in-salmonella-typhimurium-enhances-induction-of-cross-immune-responses-and-provides-protection-against-heterologous-salmonella-challenge
#12
Pei Li, Qing Liu, Chun Huang, Xinxin Zhao, Kenneth L Roland, Qingke Kong
Colanic Acid (CA) and lipopolysaccharide (LPS) are two major mannose-containing extracellular polysaccharides of Salmonella. Their presence on the bacterial surface can mask conserved protective outer membrane proteins (OMPs) from the host immune system. The mannose moiety in these molecules is derived from GDP-mannose, which is synthesized in several steps. The first two steps require the action of phosphomannose isomerase, encoded by pmi (manA), followed by phosphomannomutase, encoded by manB. There are two copies of manB present in the Salmonella chromosome, one located in the cps gene cluster (cpsG) responsible for CA synthesis, and the other in the rfb gene cluster (rfbK) involved in LPS O-antigen synthesis...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28410482/cheiro-pedal-syndrome-a-revisit-of-etiology-localization-and-outcome
#13
Wei-Hsi Chen, Hung-Sheng Lin, Chi Chui, Hsin-Ling Yin
OBJECTIVE: Cheiro-pedal syndrome (CPS) is an incomplete sensory disorder confined to hand and foot and is generally considered a benign entity. However, knowledge comes from case report or case series only. The aim of this study is to clarify the etiology, localization and outcome of CPS. PATIENT AND METHOD: A total of 21 CPS patients from our database and another 9 patients from literature were reviewed. CPS was classified into 4 types, namely unilateral and ipsilateral (Type I), bilateral (Type II), incomplete bilateral (Type III), and crossed (Type IV)...
April 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28407806/development-and-validation-of-classifiers-and-variable-subsets-for-predicting-nursing-home-admission
#14
Mikko Nuutinen, Riikka-Leena Leskelä, Ella Suojalehto, Anniina Tirronen, Vesa Komssi
BACKGROUND: In previous years a substantial number of studies have identified statistically important predictors of nursing home admission (NHA). However, as far as we know, the analyses have been done at the population-level. No prior research has analysed the prediction accuracy of a NHA model for individuals. METHODS: This study is an analysis of 3056 longer-term home care customers in the city of Tampere, Finland. Data were collected from the records of social and health service usage and RAI-HC (Resident Assessment Instrument - Home Care) assessment system during January 2011 and September 2015...
April 13, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28402712/investigation-of-a-staphylococcal-food-poisoning-outbreak-from-a-chantilly-cream-dessert-in-umbria-italy
#15
Laura Ercoli, Silvia Gallina, Yacine Nia, Frédéric Auvray, Sara Primavilla, Fabrizia Guidi, Benedetta Pierucci, Catia Graziotti, Lucia Decastelli, Stefania Scuota
On August 28, 2015, a staphylococcal food poisoning outbreak occurred in Umbria, Italy, affecting 24 of the 42 customers who had dinner at a local restaurant. About 3 h after ingesting a variety of foods, the customers manifested gastrointestinal symptoms. Within 24 h of notification from the hospital emergency department, Sanitary Inspectors of the local Public Health Unit performed an epidemiological investigation. A retrospective cohort study was conducted among the customers. Food and environmental samples were collected...
April 12, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28401831/attachment-states-of-mind-among-internationally-adoptive-and-foster-parents
#16
K Lee Raby, Heather A Yarger, Teresa Lind, R Chris Fraley, Esther Leerkes, Mary Dozier
The first aim of the current study was to examine the latent structure of attachment states of mind as assessed by the Adult Attachment Interview (AAI) among three groups of parents of children at risk for insecure attachments: parents who adopted internationally (N = 147), foster parents (N = 300), and parents living in poverty and involved with Child Protective Services (CPS; N = 284). Confirmatory factor analysis indicated the state of mind rating scales loaded on two factors reflecting adults' preoccupied and dismissing states of mind...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401501/the-sibsize-revolution-and-social-disparities-in-children-s-family-contexts-in-the-united-states-1940-2012
#17
Tony Fahey
This article points to a sharp decline in children's sibling numbers (sibsize) that occurred in the United States since the 1970s and was large enough among children with lower socioeconomic status (SES) (particularly black children) to amount to a revolution in their family circumstances. It interprets sibsize decline as a source of social convergence in children's family contexts that ran counter to trends toward social divergence caused by the rise of lone parenthood. The article is based on new estimates of differences in children's sibsize and lone parenthood by race and maternal education generated from public-use samples from the Census of Population and Current Population Survey (CPS), focusing especially on the period 1940-2012...
April 11, 2017: Demography
https://www.readbyqxmd.com/read/28394704/analysis-of-novel-meningococcal-vaccine-formulations
#18
Susu M Zughaier
The protective effect of meningococcal vaccines targeting disease causing serogroups exemplified by the introduction of MenAfriVac™ in Africa, is well established and documented in large population-based studies. Due to the emergence of other meningococcal disease causing serogroups, novel vaccine formulations are needed. There is a high potential for novel nanotechnology-based meningococcal vaccine formulations that can provide wider vaccine coverage. The proposed meningococcal vaccine formulation contains spherical shaped micro and nanoparticles that are biological mimics of Niesseria meningitidis, therefore present to immune system as invader and elicit robust immune responses...
April 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28392282/heme-nitrosylated-hemoglobin-and-oxidative-stress-in-women-consuming-combined-contraceptives-clinical-application-of-the-epr-spectroscopy
#19
Irina I Lobysheva, Sandrine van Eeckhoudt, Ahmad Rifahi, Lucie Pothen, Flavia Dei Zotti, Christophe Beauloye, Jean-Luc Balligand
An increased risk of venous thromboembolism was identified in young women consuming combined contraceptive pills (CPs) suggesting a disturbance of vascular homeostasis but the impact of CP on endothelial function and redox status of the vasculature was not thoroughly analyzed. We measured the bioavailability of nitric oxide (NO), a main mediator of vascular homeostasis in a cohort of young female subjects (n = 114) and compared the results in users or not of CPs containing ethinyl estradiol and synthetic progestogens...
April 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28389503/the-purine-receptor-p2x7r-regulates-release-of-pro-inflammatory-cytokines-in-human-craniopharyngioma
#20
Jing Nie, Guanglong Huang, Shengze Deng, Yun Bao, Yawei Liu, Zhanpeng Feng, Chaohu Wang, Ming Chen, Songtao Qi, Jun Pan
Craniopharyngiomas (CPs) are usually benign, non-metastasizing embryonic malformations originating from the sellar area. They are, however, locally invasive and generate adherent interfaces with the surrounding brain parenchyma. Previous studies have shown the tumor microenvironment is characterized by a local abundance of Adenosine Triphosphate (ATP), infiltration of leukocytes, and elevated levels of pro-inflammatory cytokines that are thought to be responsible, at least in part, for the local invasion. Here we examine whether ATP, via the P2X7R, participates in the regulation of cytokine expression in CPs...
April 7, 2017: Endocrine-related Cancer
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