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Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy Reddy Poreddy
BACKGROUND: The objective of this investigation was to develop a self emulsifying drug delivery system (SEDDS) of naproxen, a poorly water soluble drug, which could improve its solubility and oral bioavailability. Methoda: The recent patents on SEDDS of abiraterone acetate (WO2014/009434 A1) and tamoxifen (WO2013/0080083) helped in selecting the naproxen and excipients. Phase diagrams were constructed and the formulations were taken from the micro emulsion region. Formulations were subjected to thermodynamic stability, dispersibility and precipitation tests for optimization...
October 19, 2016: Recent Patents on Drug Delivery & Formulation
Joanna Szewińska, Joanna Simińska, Wiesław Bielawski
Proteolysis is an important process for development and germination of cereal seeds. Among the many types of proteases identified in plants are the cysteine proteases (CPs) of the papain and legumain families, which play a crucial role in hydrolysing storage proteins during seed germination as well as in processing the precursors of these proteins and the inactive forms of other proteases. Moreover, all of the tissues of cereal seeds undergo progressive degradation via programed cell death, which is integral to their growth...
October 20, 2016: Journal of Plant Physiology
Tomonobu Toyomasu, Koji Miyamoto, Matthew R Shenton, Arisa Sakai, Chizu Sugawara, Kiyotaka Horie, Hiroshi Kawaide, Morifumi Hasegawa, Masaru Chuba, Wataru Mitsuhashi, Hisakazu Yamane, Nori Kurata, Kazunori Okada
Cultivated rice (Oryza sativa) possesses various labdane-related diterpene synthase genes, homologs of ent-copalyl diphosphate synthase (CPS) and ent-kaurene synthase (KS) that are responsible for the biosynthesis of phytohormone gibberellins. The CPS homologs and KS like (KSL) homologs successively converted geranylgeranyl diphosphate to cyclic diterpene hydrocarbons via ent-copalyl diphosphate or syn-copalyl diphosphate in O. sativa. Consequently, a variety of labdane-related diterpenoids, including phytoalexin phytocassanes, momilactones and oryzalexins, have been identified from cultivated rice...
October 19, 2016: Biochemical and Biophysical Research Communications
Yuyan Shi, John P Pierce, Martha White, Maya Vijayaraghavan, Wilson Compton, Kevin Conway, Anne M Hartman, Karen Messer
BACKGROUND: Electronic cigarettes (e-cigarettes) are heavily marketed and widely perceived as helpful for quitting or reducing smoking intensity. We test whether ever-use of e-cigarettes among early adopters was associated with: 1) increased cigarette smoking cessation; and 2) reduced cigarette consumption. METHODS: A representative cohort of U.S. smokers (N = 2454) from the 2010 Tobacco Use Supplement to the Current Population Survey (TUS-CPS) was re-interviewed 1 year later...
October 21, 2016: BMC Public Health
Morven S Edwards, Marcia A Rench, C Daniela Rinaudo, Monica Fabbrini, Giovanna Tuscano, Giada Buffi, Erika Bartolini, Stefano Bonacci, Carol J Baker, Immaculada Margarit
Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis...
November 2016: Emerging Infectious Diseases
Parthasarathi Dastidar, Koushik Sarkar
A mixed ligand approach was exploited to synthesize a new series of MnII based coordination polymers (CPs), namely, CP1 {[Mn(-dpa)(-4,4-bp)]MeOH}α, CP2 {[Mn3(-dpa)3(2,2-bp)2]}α, CP3 {[Mn3(-dpa)3(1,10-phen)2]2H2O}α, CP4 {[Mn(-dpa)(-4,4-bpe)1.5]H2O}α, CP5 {[Mn2(-dpa)2(-4,4-bpe)2]½DEF}α and CP6 {[Mn(-dpa)(-4,4-bpe)1.5]½DMA}α, [dpa = 3,5-dicarboxy phenyl azide, 2,2-bp = 2,2-bipyridine, 1,10-phen = 1,10-phenanthroline, 4,4-bpe = 1,2-bis(4-pyridyl)ethylene, 4,4-bp = 4,4-bipyridine, DEF = N,N-diethylformamide, DMA = N,N-dimethylacetamide] to develop multifuntional CPs...
October 20, 2016: Chemistry: a European Journal
Chunyuan Wang, Xiang Liu, Xiaoli Zhao, Yongqi Wang
Conventional correction approaches are unsuitable for effectively correcting remote sensing images acquired in the seriously oblique condition which has severe distortions and resolution disparity. Considering that the extraction of control points (CPs) and the parameter estimation of the correction model play important roles in correction accuracy, this paper introduces an effective correction method for large angle (LA) images. Firstly, a new CP extraction algorithm is proposed based on multi-view simulation (MVS) to ensure the effective matching of CP pairs between the reference image and the LA image...
October 18, 2016: Sensors
Felix Meincke, Tobias Spangenberg, Felix Kreidel, Christian Frerker, Renu Virmani, Elena Ladich, Karl-Heinz Kuck, Alexander Ghanem
AIMS: Aims of this case-series were to assess the feasibility of cerebral protection devices in interventional left atrial appendage occlusion (iLAAO) procedures and to yield insight into the pathomorphological correlate of early, procedural cerebral embolization during iLAAO. METHODS AND RESULTS: Five consecutive patients underwent iLLO flanked by the Sentinel CPS® (Claret Medical, Inc., Santa Rosa, CA) cerebral protection system. Placement and recapture of the Sentinel(®) device as well as the iLAAO were successful and safe in all cases...
October 20, 2016: Catheterization and Cardiovascular Interventions
Medine Cumhur Cüre, Erkan Cüre, Yıldıray Kalkan, Aynur Kırbaş, Levent Tümkaya, Arif Yılmaz, Ayşegül Küçükali Türkyılmaz, İbrahim Şehitoğlu, Süleyman Yüce
BACKGROUND: Cisplatin (Cis) is one of the most commonly used antineoplastic drugs. It is used as chemotherapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary cancers. Infliximab blocks tumor necrosis factor alpha (TNF-α). Several studies have reported that infliximab ameliorates cell damage by reducing cytokine levels. AIMS: We aimed to investigate whether infliximab has a preventive effect against cisplatin-induced hepatotoxicity and whether it has a synergistic effect when combined with Cis...
September 2016: Balkan Medical Journal
Taous Saraoui, Josiane Cornet, Emilie Guillouet, Marie France Pilet, Frédérique Chevalier, Jean-Jacques Joffraud, Françoise Leroi
Tropical shrimp is of considerable economic importance in the world but is highly perishable due to microbial and chemical degradation. Biopreservation is a food preservation technology based on the addition of "positive" bacteria able to kill or prevent the growth of undesirable microorganisms. Two strains of lactic acid bacteria (LAB) have previously been selected for a biopreservation strategy: Lactococcus piscium CNCM I-4031, for its ability to prevent the sensory deterioration of seafood and Carnobacterium divergens V41, which inhibits growth of Listeria monocytogenes...
October 3, 2016: International Journal of Food Microbiology
Masaki Odahara, Yusuke Kobayashi, Toshiharu Shikanai, Yoshiki Nishimura
The chloroplast (cp) genome is organized as nucleoids that are dispersed throughout the cp stroma. Previously, a cp homolog of bacterial recombinase RecA (cpRECA) was shown to be involved in maintenance of cp genome integrity by repairing damaged cpDNA and by suppressing aberrant recombination between short dispersed repeats (SDRs) in the moss Physcomitrella patens. Here, overexpression and knockdown analysis of cpRECA in the green alga Chlamydomonas reinhardtii revealed that cpRECA was involved in cp nucleoid dynamics as well as having a role in maintaining cp genome integrity...
October 17, 2016: Plant Physiology
Aun Raza, Feng Li, Xiuquan Xu, Jian Tang
Response surface methodology (RSM) was used to optimize experimental conditions for ultrasonic-assisted extraction (UAE) of antioxidant crude polysaccharides (CPS) from Trapa quadrispinosa stems. Antioxidant capacity of polysaccharides was determined by Ferric-Reducing Antioxidant Capacity (FRAC) assay with the method of 1, 10-phenanthroline. The maximum yield of polysaccharides (2.78±0.16%) was obtained under optimal extraction conditions of extraction time, 41min; ratio of water to material, 31.5mL/g; and extraction temperature, 58°C...
October 14, 2016: International Journal of Biological Macromolecules
Anna Elander, Christina Persson, Jan Lilja, Hans Mark
A staged protocol for isolated cleft palate (CPO), comprising the early repair of the soft palate at 6 months and delayed repair of the eventual cleft in the hard palate until 4 years, designed to improve maxillary growth, was introduced. CPO is frequently associated with additional congenital conditions. The study evaluates this surgical protocol for clefts in the soft palate (CPS) and for clefts in the hard and soft palate (CPH), with or without additional malformation, regarding primary and secondary surgical interventions needed for cleft closure and for correction of velopharyngeal insufficiency until 10 years of age...
October 18, 2016: Journal of Plastic Surgery and Hand Surgery
Qi Mo, Jiale He, Dawei Yu, Lei Deng, Songnian Fu, Ming Tang, Deming Liu
We experimentally demonstrate a 4.46  Gb/s2×2 multi-input multi-output (MIMO) orthogonal frequency division multiplexing (OFDM)/OQAM radio signal over a 2 km elliptical core 3-mode fiber, together with 0.4 m wireless transmission. Meanwhile, to cope with differential channel delay (DCD) among involved MIMO channels, we propose a time-offset crosstalk cancellation algorithm to extend the DCD tolerance from 10 to 60 ns without using a circle prefix (CP), leading to an 18.7% improvement of spectral efficiency...
October 1, 2016: Optics Letters
Sitah F Alanazi, Khalid S Alzimami, Magdy M Ghannam, Ibrahim J Aljammaz, Faisal Alrumayan, Salem A Sassi
PURPOSE: Interest in PET imaging using zirconium-89 (Zr) (t1/2=78.41 h)-labeled tracers for the tracking and quantification of monoclonal antibodies (mAbs) is growing, mainly because of its well-matched physical half-life with the biological half-life of intact mAbs. This study aims to evaluate the imaging characteristics of Zr-PET in comparison with those obtained using fluorine-18 fluorodeoxyglucose (F-FDG) PET (gold standard tracer in PET imaging) using a Time-Of-Flight (TOF) PET/computed tomography (CT) scanner...
October 4, 2016: Nuclear Medicine Communications
Laura Vannini, Judith H Willis
Previous work with EM immunolocalization examined the intracuticular placement of several antibodies directed against cuticular proteins (CPs) in various structures of Anopheles gambiae. Those structures had long stretches of fairly uniform cuticle. We have now used 19 antibodies directed against members of five CP families on two adult structures with considerable complexity, Johnston's organ and the corneal lens of the compound eye. We also localized chitin with colloidal-gold labeled wheat germ agglutinin...
October 12, 2016: Arthropod Structure & Development
Taeko Mizutani, Hijiri Sumida, Yuki Sagawa, Yuri Okano, Hitoshi Masaki
BACKGROUND: Carbonylated proteins (CPs) are generated by the reaction of basic amino acid residues in proteins with aldehyde compounds produced during lipid peroxidation. CPs in the stratum corneum (SC) impact skin conditions such as skin moisture functions including water content and transepidermal water loss (TEWL). In addition, CPs can be frequently seen in the SC from sun-exposed sites compared with sun-protected sites. OBJECTIVE: The aim of this study was to reveal whether CPs could be a generation source of reactive oxygen species (ROS) in the SC following exposure to ultraviolet (UV) radiation and to identify the type of ROS and its generation mechanism...
September 28, 2016: Journal of Dermatological Science
Jing-Wang Cui, Wei-Jia An, Kristof Van Hecke, Guang-Hua Cui
Two Cu(i) cyanide coordination polymers (CPs), namely, [Cu2(L1)(CN)2]n (1) and [Cu2(L2)(CN)2]n (2) (L1 = 4,4'-bis(2-methylbenzimidazol-1-ylmethyl)biphenyl, L2 = 4,4'-bis(5,6-dimethylbenzimidazol-1-ylmethyl)biphenyl) were synthesized and structurally characterized by single crystal X-ray diffraction, IR spectroscopy, X-ray powder diffraction and elemental analysis. The cyanide ligands in these CPs are generated in situ from the C-C bond cleavage of acetonitrile under solvothermal conditions, which is environmentally friendly and used conveniently...
October 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Jason L J Lin, Chyuan-Chuan Wu, Wei-Zen Yang, Hanna S Yuan
Endonuclease G (EndoG) is an evolutionarily conserved mitochondrial protein in eukaryotes that digests nucleus chromosomal DNA during apoptosis and paternal mitochondrial DNA during embryogenesis. Under oxidative stress, homodimeric EndoG becomes oxidized and converts to monomers with diminished nuclease activity. However, it remains unclear why EndoG has to function as a homodimer in DNA degradation. Here, we report the crystal structure of the Caenorhabditis elegans EndoG homologue, CPS-6, in complex with single-stranded DNA at a resolution of 2...
October 13, 2016: Nucleic Acids Research
Constantin Hays, Mathilde Louis, Céline Plainvert, Nicolas Dmytruk, Gérald Touak, Patrick Trieu-Cuot, Claire Poyart, Asmaa Tazi
Group B Streptococcus (GBS) is the leading cause of neonatal invasive infections and an emerging pathogen in the elderly. Our objectives were to describe the evolution of GBS resistance to antibiotics in France and to investigate the emergence of fluoroquinolone (FQ) resistant isolates. A total of 8,757 unrelated GBS isolates were collected and tested for antibiotic susceptibility from 2007 and 2014 according to EUCAST recommendations. All isolates were susceptible to penicillin G, amoxicillin, and vancomycin...
October 10, 2016: Antimicrobial Agents and Chemotherapy
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