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https://www.readbyqxmd.com/read/29343433/oxysterol-sensing-through-the-receptor-gpr183-promotes-the-lymphoid-tissue-inducing-function-of-innate-lymphoid-cells-and-colonic-inflammation
#1
Johanna Emgård, Hana Kammoun, Bethania García-Cassani, Julie Chesné, Sara M Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J Villablanca, Henrique Veiga-Fernandes, João P Pereira, Richard A Flavell, Tim Willinger
Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which signals are sensed and what receptors control ILC3 function remain poorly understood. Here, we show that ILC3s with a lymphoid-tissue-inducer (LTi) phenotype expressed G-protein-coupled receptor 183 (GPR183) and migrated to its oxysterol ligand 7α,25-hydroxycholesterol (7α,25-OHC). In mice lacking Gpr183 or 7α,25-OHC, ILC3s failed to localize to cryptopatches (CPs) and isolated lymphoid follicles (ILFs)...
January 16, 2018: Immunity
https://www.readbyqxmd.com/read/29342882/implication-of-soluble-forms-of-cell-adhesion-molecules-in-infectious-disease-and-tumor-insights-from-transgenic-animal-models
#2
REVIEW
Etsuro Ono, Toshimitsu Uede
Cell adhesion molecules (CAMs) are surface ligands, usually glycoproteins, which mediate cell-to-cell adhesion. They play a critical role in maintaining tissue integrity and mediating migration of cells, and some of them also act as viral receptors. It has been known that soluble forms of the viral receptors bind to the surface glycoproteins of the viruses and neutralize them, resulting in inhibition of the viral entry into cells. Nectin-1 is one of important CAMs belonging to immunoglobulin superfamily and herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336512/using-field-data-to-quantify-chemical-impacts-on-wildlife-population-viability
#3
Jelle P Hilbers, Renske P J Hoondert, Aafke M Schipper, Mark A J Huijbregts
Environmental pollution is an important driver of biodiversity loss. Yet, to date, the effects of chemical exposure on wildlife populations have been quantified for only a few species, mainly due to a lack of appropriate laboratory data to quantify chemical impacts on vital rates. In this study we developed a method to quantify the effects of toxicant exposure on wildlife population persistence based on field monitoring data. We established field-based vital rate-response functions for toxicants, using quantile regression to correct for the influences of confounding factors on the vital rates observed, and combined the response curves with population viability modelling...
January 16, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29333070/bacterial-infections-in-patients-with-liver-cirrhosis-clinical-characteristics-and-the-role-of-c-reactive-protein
#4
Melanie Deutsch, Spilios Manolakopoulos, Ioannis Andreadis, Markos Giannaris, George Kontos, Hariklia Kranidioti, Maria Pirounaki, John Koskinas
Background: The diagnosis of bacterial infection in cirrhotic patients may be difficult, because of the absence of classical signs such as fever and raised white blood cell count. The role of C-reactive protein (CRP) in this context has not been clearly defined. Methods: Clinical and laboratory characteristics of 210 consecutive cirrhotic patients with (n=100) or without (n=110) bacterial infection were compared with a control group of non-cirrhotic patients with infection (n=106)...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29329886/solid-phase-extraction-of-chlorophenols-in-seawater-using-a-magnetic-ionic-liquid-molecularly-imprinted-polymer-with-incorporated-silicon-dioxide-as-a-sorbent
#5
Wanwan Ma, Kyung Ho Row
A type of magnetic ionic liquid based molecularly imprinted polymer coated on SiO2 (Fe3O4@SiO2@IL-MIPs) was prepared with 1-vinyl-3-ethylimidazole ionic liquid as functional monomer, and 1,4-butane-3,3'-bis-1-ethylimidazole ionic liquid as cross linker, 4-Chlorophenol as template was successfully applied as a selective adsorbent for selective extraction of 5 chlorophenols in seawater samples by using the magnetic solid-phase extraction (MSPE) method. 11 types of Fe3O4@SiO2@IL-MIPs were synthesized and investigated for their different compositions of functional monomer (such as [C2min][Br], [C2min][BF4], [C2min][PF6], acrylamide, methacrylic acid and 4-vinyl pyridine) and cross-linker (such as [C4min2][Br], [C4min2][BF4], [C4min2][PF6], divinylbenzene, and ethylene glycol dimethacrylate), respectively...
January 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29327416/comparative-proteomics-studies-of-insect-cuticle-by-tandem-mass-spectrometry-application-of-a-novel-proteomics-approach-to-the-pea-aphid-cuticular-proteins
#6
Masson Victor, Arafah Karim, Voisin Sébastien, Bulet Philippe
The exoskeleton of arthropods, called cuticle, is a biological composite material consisting principally of N-acetylglucosamine polymer embedded in cuticular proteins (CPs). The CPs have been studied and characterized by mass spectrometry in several cuticular structures and in many arthropods. Such analyses were usually carried out by protein extraction using SDS detergent followed by electrophoresis, allowing detection and identification of a large number of CPs. To build a repertoire of cuticular structures from Bombyx mori, Apis mellifera and Anopheles gambiae we avoided the use of SDS and electrophoresis...
January 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29327351/negotiating-inter-professional-interaction-playing-the-general-practitioner-pharmacist-game
#7
Fay Bradley, Darren M Ashcroft, Nick Crossley
Despite a mutual interest in optimising the benefits of medication for patients, the general practitioner (GP) and community pharmacist (CP) often work in isolation from one another, both physically and figuratively. Sources of tension include pharmacy's 'shopkeeper' image, traditional medical hierarchies and potential encroachment on professional boundaries. This article examines GP and CP perceptions of their interactions and negotiations and, drawing on the works of Stein and Goffman, identifies a set of 'unwritten' rules, termed the 'GP-pharmacist game', which involves the concept of 'face-work'...
January 12, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29327043/association-of-oral-microbiome-with-risk-for-incident-head-and-neck-squamous-cell-cancer
#8
Richard B Hayes, Jiyoung Ahn, Xiaozhou Fan, Brandilyn A Peters, Yingfei Ma, Liying Yang, Ilir Agalliu, Robert D Burk, Ian Ganly, Mark P Purdue, Neal D Freedman, Susan M Gapstur, Zhiheng Pei
Importance: Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC. Objective: To prospectively examine associations between the oral microbiome and incident HNSCC. Design, Setting, and Participants: This nested case-control study was carried out in 2 prospective cohort studies: the American Cancer Society Cancer Prevention Study II Nutrition Cohort (CPS-II) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
January 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29325427/a-randomized-trial-of-home-visitation-for-cps-involved-families-the-moderating-impact-of-maternal-depression-and-cps-history
#9
Melissa Jonson-Reid, Brett Drake, John N Constantino, Mini Tandon, Laura Pons, Patricia Kohl, Scott Roesch, Ellie Wideman, Allison Dunnigan, Wendy Auslander
Home visitation (HV) interventions may hold promise to improve parenting and prevent child maltreatment recidivism in families reported to child protective services (CPS) with young children, but this has rarely been studied. Findings are presented from an 18-month randomized controlled trial in which intact families ( N = 122) with at least one CPS report were provided with a facilitated connection to a paraprofessional evidence-based HV program or usual care services from child protection. Results are reported for changes in maternal stress, depression, and social support outcomes and repeat reports to CPS...
January 1, 2018: Child Maltreatment
https://www.readbyqxmd.com/read/29324038/the-evolution-and-metamorphosis-of-arthropod-proteomics-and-genomics
#10
Judith H Willis
This article presents an overview of the development of techniques for analyzing cuticular proteins (CPs), their transcripts, and their genes over the past 50 years based primarily on experience in the laboratory of J.H. Willis. It emphasizes changes in the kind of data that can be gathered and how such data provided insights into the molecular underpinnings of insect metamorphosis and cuticle structure. It describes the techniques that allowed visualization of the location of CPs at both the anatomical and intracuticular levels and measurement of the appearance and deployment of transcripts from CP genes as well as what was learned from genomic and transcriptomic data...
January 7, 2018: Annual Review of Entomology
https://www.readbyqxmd.com/read/29322149/exploring-physical-and-chemical-properties-in-new-multifunctional-indium-bismuth-and-zinc-based-1d-and-2d-coordination-polymers
#11
G E Gomez, R F D'vries, D F Lionello, L M Aguirre-Díaz, M Spinosa, C S Costa, M C Fuertes, R A Pizarro, A M Kaczmarek, J Ellena, L Rozes, M Iglesias, R Van Deun, C Sanchez, M A Monge, G J A A Soler-Illia
Main group element coordination polymers (MGE-CPs) are important compounds for the development of multifunctional materials. However, there has been a shortage of studies regarding their structural, optical, catalytic, mechanical, and antibacterial properties. This work presents an exhaustive study of a set of crystalline MGE-CPs obtained from bismuth and indium metals and iminodiacetate, 1,2,4,5-benzenetetracarboxylate, and 2,2'-bipyridine as building blocks. An in-depth topological analysis of the networks was carried out...
January 11, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29317173/identification-of-a-proteomic-biomarker-associated-with-invasive-st1-serotype-vi-group-b-streptococcus-by-maldi-tof-ms
#12
Hsiao-Chuan Lin, Jang-Jih Lu, Lee-Chung Lin, Cheng-Mao Ho, Kao-Pin Hwang, Yu-Ching Liu, Chao-Jung Chen
BACKGROUND: Group B Streptococcus (GBS) is an important invasive pathogen in neonates, pregnant women and the elderly. Serotype VI GBS, which has been rarely reported globally, has emerged as a significant pathogen in Asia. However, traditional serologic latex agglutination (LA) methods may fail to type isolates that lack of or low expression of CPS. METHODS: A total of 104 GBS strains were analyzed by MALDI-TOF MS. Multiplex PCR and multilocus sequence typing (MLST) were also performed to confirm their strains...
December 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29314571/relative-changes-in-handgrip-strength-and-skeletal-muscle-volume-in-patients-with-chronic-liver-disease-over-two-year-observation-period
#13
Atsushi Hiraoka, Kojiro Michitaka, Hirofumi Izumoto, Hidetaro Ueki, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Yuji Miyamoto, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Yoichi Hiasa
BACKGROUND/AIM: There are few reports regarding relative changes in muscle function of patients with chronic liver disease (CLD). We examined CLD patients to evaluate relative changes in handgrip strength and muscle volume. MATERIAL/METHODS: We enrolled 413 CLD outpatients who underwent handgrip strength measurements in both 2015 and 2017 [age 67.9±10.0 years, male/female=242/171, HCV/HBV/HBV&HCV/alcohol/others=239/92/4/22/56, Child-Pugh score (CPS) in 2017 (5/6/7/8/9/≥10=319/56/13/11/5/9)]...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29311231/capsule-prolongs-survival-of-streptococcus-pneumoniae-during-starvation
#14
Shigeto Hamaguchi, M Ammar Zafar, Michael Cammer, Jeffrey N Weiser
Person-to-person transmission of Streptococcus pneumoniae (the pneumococcus) may occur via environmental sources in close contact with carriers. Pneumococcal polysaccharide capsules, the determinant of serotype (or type), are heterogeneous in structure and amount and these differences affect rates of transmission. In this study, we examined the contribution of capsule and its variations to the maintenance of pneumococcal viability under starvation conditions. S. pneumoniae retained its ability to colonize infant mice even after incubation for 24hrs in PBS at 25°C...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29305053/structure-kinetics-molecular-and-redox-properties-of-a-cytosolic-and-developmentally-regulated-fungal-catalase-peroxidase
#15
Vanessa Vega-García, Adelaida Díaz-Vilchis, Juan-Pablo Saucedo-Vázquez, Alejandro Solano-Peralta, Enrique Rudiño-Piñera, Wilhelm Hansberg
CAT-2, a cytosolic catalase-peroxidase (CP) from Neurospora crassa, which is induced during asexual spore formation, was heterologously expressed and characterized. CAT-2 had the Met-Tyr-Trp adduct required for catalase activity. Its KM for H2O2 was micromolar for peroxidase and millimolar for catalase activity. A Em = -158 mV reduction potential value was obtained and the Soret band shift suggested a mixture of low and high spin ferric iron. CAT-2 EPR spectrum at 10 K indicated an axial and a rhombic component...
January 2, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29304546/mannose-modificated-polyethyleneimine-a-specific-and-effective-antibacterial-agent-against-escherichia-coli
#16
Mei Liu, Jiao Li, Baoxin Li
Polyethyleneimine (PEI) has antimicrobial activity against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli), but it possesses highly cytotoxic and the selective antimicrobial activity against S. aureus is obviously better than E. coli. To reduce the cytotoxicity and improve the antibacterial activity against E. coli, we modified PEI by D-mannose through nucleophilic addition between primary amine and aldehyde group to get mannose-modificated polyethyleneimine copolymer particles (Man-PEI CPs)...
January 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29300154/acinetobacter-baumannii-isolate-bal_212-from-vietnam-produces-the-k57-capsular-polysaccharide-containing-a-rarely-occurring-amino-sugar-n-acetylviosamine
#17
Johanna J Kenyon, Anastasiya A Kasimova, Alexander S Shashkov, Ruth M Hall, Yuriy A Knirel
The structures of capsular polysaccharides (CPSs) produced by different Acinetobacter baumannii strains have proven to be invaluable in confirming the role of specific genes in the synthesis of rare sugars through the correlation of genetic content at the CPS biosynthesis locus with sugars found in corresponding CPS structures. A module of four genes (rmlA, rmlB, vioA and vioB) was identified in the KL57 capsule biosynthesis gene cluster of A. baumannii isolate BAL_212 from Vietnam. These genes were predicted to direct the synthesis of 4-acetamido-4,6-dideoxy-d-glucose (N-acetylviosamine, d-Qui4NAc) and the K57 CPS was found to contain this monosaccharide...
January 4, 2018: Microbiology
https://www.readbyqxmd.com/read/29297915/assembly-of-a-series-of-coordination-polymers-built-from-rigid-a-tetracarboxylate-ligand-and-flexible-bis-imidazole-linker-syntheses-structural-diversities-luminescence-sensing-and-photocatalytic-properties
#18
Xiu-Tang Zhang, Hong-Tai Chen, Bin Li, Guang-Zeng Liu, Xin-Zheng Liu
Hydrothermal reactions of aromatic terphenyl-4,2'',5'',4'-tetracarboxylic acid (H4tta) and transitional metal cations in the presence of two flexible N-donor ancillary ligands afforded four novel coordination polymers, namely, {[Zn(tta)0.5(m-bimb)]·H2O}n (1), [Ni2(tta)(m-bimb)2(H2O)]n (2), [Ni(H2tta)(o-bimb)·H2O]n (3), and [Cd(tta)0.5(o-bimb)]n (4), from solvothermal reactions in the presence of bis(imidazole) bridging linkers (m-bimb = 1,3-bis(imidazol-1-ylmethyl)benzene, and o-bimb = 1,2-bis(imidazol-1-ylmethyl)benzene)...
January 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29297821/isolation-identification-and-genome-analysis-of-lung-pathogenic-klebsiella-pneumoniae-lpkp-in-forest-musk-deer
#19
Wei Zhao, Qing Tian, Yan Luo, Yin Wang, Ze-Xiao Yang, Xue-Ping Yao, Jian-Guo Cheng, Xin Zhou, Wu-You Wang
Klebsiella pneumoniae is an important pathogen commonly associated with opportunistic infections. In this study, lung pathogenic K. pneumoniae (LPKP) was isolated and identified from suppurative pneumoniae in forest musk deer by conventional methods and by 16S ribosomal RNA sequence analysis. Median lethal dose and histopathologic analysis were used to demonstrate pathogenicity of the organism in mice. Furthermore, a draft genome of LPKP was sequenced, and its virulence genes were detected. One hundred and twenty-two virulence genes encoded determinant of capsule polysaccharide (CPS), lipopolysaccharide, fimbriae, outer membrane proteins, iron acquisition, and urease...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29295912/role-of-heat-shock-proteases-in-quorum-sensing-mediated-regulation-of-biofilm-formation-by-vibrio-species
#20
Kyung-Jo Lee, You-Chul Jung, Soon-Jung Park, Kyu-Ho Lee
Capsular polysaccharide (CPS) is essential for the dispersal of biofilms formed by the pathogenic bacterium Vibrio vulnificus CPS production is induced by the quorum-sensing (QS) master regulator SmcR when biofilms mature. However, V. vulnificus biofilms formed under heat shock conditions did not exhibit the dispersion stage. Transcripts of the CPS gene cluster were at basal levels in the heat-exposed cell owing to reduced cellular levels of SmcR. At least two proteases induced by heat shock, ClpPA and Lon, were responsible for determining the instability of SmcR...
January 2, 2018: MBio
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