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https://www.readbyqxmd.com/read/29434730/clinical-and-pathological-characteristics-of-igg4-related-interstitial-lung-disease
#1
Xiaoting Lv, Feng Gao, Qicai Liu, Sheng Zhang, Zhihua Huang, Yongping Zhu, Haiyang Zong, Quwen Li, Sanyan Li
IgG4-related interstitial lung disease (IgG4-RILD), which is characterized by increased IgG4 levels, IgG4 + plasma cell infiltration and irregular whorled fibrosis, is a recently described lung disorder that belongs to the group of systemic fibroinflammatory IgG4-related diseases (IgG4-RD). The aim of the present study was to improve the current knowledge regarding the specific clinical and histopathological characteristics of IgG4-RILD and to investigate its underlying immune mechanism in vivo . A total of 7 patients newly diagnosed with IgG4-RILD were enrolled in the present study (4 men and 3 women; mean age, 57 years; range, 29-71 years)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29384927/efficacy-and-safety-of-micafungin-for-the-treatment-of-patients-with-proven-or-probable-invasive-aspergillosis-a-non-comparative-multicenter-phase-iv-open-label-study
#2
Yu Ji, Yongping Song, Fang Zhou, Ting Liu, Ming Jiang, Xielan Zhao, Xiaojun Huang
INTRODUCTION: Few studies have assessed the efficacy and safety of micafungin in patients with proven or probable invasive aspergillosis (IA). This was the aim of the current study, which was conducted in 22 hospitals in China, where micafungin was approved for treatment of IA in 2006. METHODS: This was a non-comparative, phase IV open-label study (NCT02646774). Eligible patient were adults with proven or probable IA. Efficacy endpoints included rates of overall treatment success (primary endpoint) and clinical improvement, fungal clearance, mortality, and the site of Aspergillus infection (all secondary endpoints)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383157/celecoxib-targets-breast-cancer-stem-cells-by-inhibiting-the-synthesis-of-prostaglandin-e2-and-down-regulating-the-wnt-pathway-activity
#3
Chaolin Huang, Yuanhong Chen, Hang Liu, Jing Yang, Xuejing Song, Junping Zhao, Na He, Chengji J Zhou, Yongping Wang, Changjiang Huang, Qiaoxiang Dong
Pharmacological targeting of breast cancer stem cells (CSCs) is highly promising for the treatment of breast cancer, as the small population of CSCs is responsible for tumor initiation, progression, recurrence and chemo-resistance. Celecoxib is one of the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs), which have chemo-preventive activity against cancers, including breast cancer and colorectal cancer. However, the mechanisms by which NSAIDs exert its cancer prevention effects have yet been completely understood...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29352288/phospholipid-scramblase-1-interacts-with-influenza-a-virus-np-impairing-its-nuclear-import-and-thereby-suppressing-virus-replication
#4
Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP). As a major component of the vRNP complex, the viral nucleoprotein (NP) mediates the nuclear import of the vRNP complex via its nuclear localization signals (NLSs). Clearly, an effective way for the host to antagonize IAV infection would be by targeting vRNP nuclear import. Here, we identified phospholipid scramblase 1 (PLSCR1) as a binding partner of NP by using a yeast two-hybrid (Y2H) screen...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29337139/identification-of-yellow-gene-family-in-agrotis-ipsilon-and-functional-analysis-of-aiyellow-y-by-crispr-cas9
#5
Xi'en Chen, Yanghui Cao, Shuai Zhan, Yong Zhang, Anjiang Tan, Yongping Huang
The yellow gene family has been identified in several model insects, but yellow genes were poorly identified in non-model insects and the functions of yellow genes are largely unknown. In this study, we identified seven yellow genes in an important agricultural pest Agrotis ipsilon. Each gene encodes a protein containing a major royal jelly domain. Phylogenetic analysis defined these genes as yellow-y, -b, -b2, -c, -d, -e, and -h, respectively. The A. ipsilon yellow genes yellow-b, -b2, and -c were stably expressed in all developmental stages and tissues analyzed, whereas the other four yellow genes had unique expression patterns, suggesting distinct physiological roles of each gene...
January 11, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29316730/novel-synthesis-of-slightly-fluorinated-graphene-quantum-dots-with-luminescent-and-paramagnetic-properties-through-thermal-cutting-of-fluorinated-graphene
#6
Qian Feng, Wenqing Xiao, Yuan Liu, Yongping Zheng, Yuda Lin, Jiaxin Li, Qingying Ye, Zhigao Huang
A novel approach has been developed to synthesize slightly fluorinated graphene quantum dots (GQDs-F) through thermal cutting of highly fluorinated graphene. The fluorinated graphene with substantial structure defects is fragile and is readily attacked. The direct evaporation of abundant CFn (n = 2, 3) groups near structure defects lead to the loss of adjacent skelton C atoms, and the fluorinated graphene can be thermally cut into GQDs-F with a relatively uniform nanosize in pyrolysis at 810 K. The GQDs-F with a low F/C atomic ratio of ca...
January 8, 2018: Materials
https://www.readbyqxmd.com/read/29297099/assessment-of-corneal-biomechanical-properties-with-inflation-test-using-optical-coherence-tomography
#7
Like Wang, Lei Tian, Yanping Huang, Yifei Huang, Yongping Zheng
Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method...
January 2, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29288754/microrna-14-regulates-larval-development-time-in-bombyx-mori
#8
Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan
MicroRNAs (miRNA) regulate multiple physiological processes including development and metamorphosis in insects. In the current study, we demonstrate that a conserved invertebrate miRNA-14 (miR-14) plays an important role in ecdysteroid regulated development in the silkworm Bombyx mori, a lepidopteran model insect. Ubiquitous transgenic overexpression of miR-14 using the GAL4/UAS system resulted in delayed silkworm larval development and smaller body size of larva and pupa with decrease in ecdysteriod titers...
February 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29286155/mesenchymal-stem-cells-reverse-high%C3%A2-fat-diet%C3%A2-induced-non%C3%A2-alcoholic-fatty-liver-disease-through-suppression-of-cd4-t-lymphocytes-in-mice
#9
Huafeng Wang, Huan Zhang, Biao Huang, Guolin Miao, Xiaoyan Yan, Gang Gao, Yongping Luo, Huize Chen, Wei Chen, Luhong Yang
Although the multipotency of mesenchymal stem cells (MSCs) makes them an attractive choice for clinical applications, immune modulation is an important factor affecting MSC transplantation. At present, the effect of treatment with MSCs on non‑alcoholic fatty liver disease (NAFLD) has received little attention. In the present study, a compact bone‑derived method was used to isolate mouse MSCs (mMSCs) and a high‑fat diet was used to establish a mouse model of NAFLD. Immunophenotypic features of mMSCs were analyzed using flow cytometry...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29259988/increased-circulating-th17-but-decreased-cd4-foxp3-treg-and-cd19-cd1dhicd5-breg-subsets-in-new-onset-graves-disease
#10
Jing Qin, Jin Zhou, Chenling Fan, Na Zhao, Yongping Liu, Shuo Wang, Xuejiao Cui, Mingshi Huang, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Th17 and regulatory lymphocyte subsets such as Tregs and Bregs have been reported to play important roles in autoimmune diseases. The aim of this work was to perform quantitative studies of circulating Th17, Tregs, and Bregs in patients with new-onset Graves' disease (GD). Twenty GD patients and 20 healthy controls were involved in this study. Blood samples were taken for flow cytometry detection of CD4+IL-17+ Th17, CD4+Foxp3+ Tregs, and CD19+CD1dhiCD5+ Bregs and meanwhile, for real-time PCR measurement of gene expressions of RORγt, IL-17 and IL-10...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238988/plerixafor-and-granulocyte-colony-stimulating-factor-for-mobilization-of-hematopoietic-stem-cells-for-autologous-transplantation-in-chinese-patients-with-non-hodgkin-s-lymphoma-a-randomized-phase-3-study
#11
Jun Zhu, Huiqiang Huang, Huan Chen, Xi Zhang, Zengjun Li, Depei Wu, Daobin Zhou, Yongping Song, Yu Hu, Yingmin Liang, Hanyun Ren, He Huang, Nainong Li, Hu Chen, Jiong Hu, Jianyong Li, Robin Meng, Junlong Wu, Dong Yu, Xiaojun Huang
BACKGROUND: This Phase 3 randomized, double-blind study evaluated the efficacy and safety of plerixafor plus granulocyte-colony-stimulating factor for the mobilization of hematopoietic stem cells in Chinese patients with non-Hodgkin's lymphoma. STUDY DESIGN AND METHODS: Adults (ages 18-75 years) with non-Hodgkin's lymphoma in first or second complete or partial remission, without previous hematopoietic stem cell mobilization or autologous transplant, were included...
December 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29229515/oxyr-of-haemophilus-parasuis-is-a-global-transcriptional-regulator-important-in-oxidative-stress-resistance-and-growth
#12
Yongping Wen, Yiping Wen, Xintian Wen, Sanjie Cao, Xiaobo Huang, Rui Wu, Qin Zhao, Mafeng Liu, Yong Huang, Qigui Yan, Xinfeng Han, Xiaoping Ma, Ke Dai, Lingqiang Ding, Sitong Liu, Jian Yang
Haemophilus parasuis is an opportunistic pathogen and the causative agent of Glässer's disease in swine. This disease has high morbidity and mortality rates in swine populations, and is responsible for major economic losses worldwide. Survival of H. parasuis within the host requires mechanisms for coping with oxidative stress conditions. In many bacteria, OxyR is known to mediate protection against oxidative stress; however, little is known about the role of OxyR in H. parasuis. In the current study, an oxyR mutant strain was constructed in H...
December 8, 2017: Gene
https://www.readbyqxmd.com/read/28928275/development-of-diagnostic-criteria-and-a-prognostic-score-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#13
Tianzhou Wu, Jiang Li, Li Shao, Jiaojiao Xin, Longyan Jiang, Qian Zhou, Dongyan Shi, Jing Jiang, Suwan Sun, Linfeng Jin, Ping Ye, Lingling Yang, Yinyun Lu, Tan Li, Jianrong Huang, Xiaowei Xu, Jiajia Chen, Shaorui Hao, Yuemei Chen, Shaojie Xin, Zhiliang Gao, Zhongping Duan, Tao Han, Yuming Wang, Jianhe Gan, Tingting Feng, Chen Pan, Yongping Chen, Hai Li, Yan Huang, Qing Xie, Shumei Lin, Lanjuan Li, Jun Li
OBJECTIVE: The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective of aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients. DESIGN: The clinical data from 1322 hospitalised patients with acute decompensation of cirrhosis or severe liver injury due to chronic hepatitis B (CHB) at 13 liver centres in China were used to develop new diagnostic and prognostic criteria...
September 19, 2017: Gut
https://www.readbyqxmd.com/read/28927827/crispr-cas9-mediated-blos2-knockout-resulting-in-disappearance-of-yellow-strips-and-white-spots-on-the-larval-integument-in-spodoptera-litura
#14
Guan-Heng Zhu, Ying-Chuan Peng, Mei-Yan Zheng, Xiao-Qing Zhang, Jia-Bin Sun, Yongping Huang, Shuang-Lin Dong
The custom-design bacterial CRISPR/Cas9 system has been recently used in some insects, indicating a powerful technique for studies on gene function and transgenic insects. However, its use in lepidopteran pests is scarce. Here, we reported a CRISPR/Cas9 system mediated mutagenesis of biogenesis of lysosome-related organelles complex1, subunit 2 (BLOS2) gene in a noctuid pest Spodoptera litura. A fragment of SlitBLOS2 was identified by analyzing a S. litura transcriptome database by local basic BLAST, and the full length cDNA was acquired by RACE strategy...
September 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28890398/functional-characterization-of-pol-iii-u6-promoters-for-gene-knockdown-and-knockout-in-plutella-xylostella
#15
Yuping Huang, Yajun Wang, Baosheng Zeng, Zhaoxia Liu, Xuejiao Xu, Qian Meng, Yongping Huang, Guang Yang, Liette Vasseur, Geoff M Gurr, Minsheng You
RNA polymerase type III (Pol-III) promoters such as U6 are commonly used to express small RNAs, including short hairpin RNAs (shRNAs) and single guide RNAs (sgRNAs). Functional U6 promoters are widely used in CRISPR systems, and their characterization can facilitate genome editing of non-model organisms. In the present study, six U6 small nuclear RNA (snRNA) promoters containing two conserved elements of a proximal sequence element (PSEA) and a TATA box, were identified and characterized in the diamondback moth (Plutella xylostella) genome...
October 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28807054/transcriptomic-profile-of-tobacco-in-response-to-tomato-zonate-spot-orthotospovirus-infection
#16
Changjun Huang, Yupeng Cun, Haiqin Yu, Zhijun Tong, Bingguang Xiao, Zhongbang Song, Bingwu Wang, Yongping Li, Yong Liu
BACKGROUND: Tomato zonate spot virus (TZSV), a dominant species of thrips-transmitted orthotospoviruses in Yunnan and Guangxi provinces in China, causes significant loss of yield in lots of crops and is a major threat to incomes of rural families. However, the detailed molecular mechanism of crop disease caused by TZSV remains obscure. METHODS: Next-generation sequencing (NGS)-based transcriptome analysis (RNA-seq) was performed to investigate and compare the gene expression changes in systemic leaves of tobacco upon infection with TZSV and mock-inoculated plants as a control...
August 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28676809/phylogenomic-analysis-and-dynamic-evolution-of-chloroplast-genomes-in-salicaceae
#17
Yuan Huang, Jun Wang, Yongping Yang, Chuanzhu Fan, Jiahui Chen
Chloroplast genomes of plants are highly conserved in both gene order and gene content. Analysis of the whole chloroplast genome is known to provide much more informative DNA sites and thus generates high resolution for plant phylogenies. Here, we report the complete chloroplast genomes of three Salix species in family Salicaceae. Phylogeny of Salicaceae inferred from complete chloroplast genomes is generally consistent with previous studies but resolved with higher statistical support. Incongruences of phylogeny, however, are observed in genus Populus, which most likely results from homoplasy...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28654747/confining-sulfur-in-n-doped-porous-carbon-microspheres-derived-from-microalgaes-for-advanced-lithium-sulfur-batteries
#18
Yang Xia, Ruyi Fang, Zhen Xiao, Hui Huang, Yongping Gan, Rongjun Yan, Xianghong Lu, Chu Liang, Jun Zhang, Xinyong Tao, Wenkui Zhang
Lithium-sulfur (Li-S) battery is one of the most attractive candidates for the next-generation energy storage system. However, the intrinsic insulating nature of sulfur and the notorious polysulfide shuttle are the major obstacles, which hinder the commercial application of Li-S battery. Confining sulfur into conductive porous carbon matrices with designed polarized surfaces is regarded as a promising and effective strategy to overcome above issues. Herein, we propose to use microalgaes (Schizochytrium sp.) as low-cost, renewable carbon/nitrogen precursors and biological templates to synthesize N-doped porous carbon microspheres (NPCMs)...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28577927/deletion-of-the-bombyx-mori-odorant-receptor-co-receptor-bmorco-impairs-olfactory-sensitivity-in-silkworms
#19
Qun Liu, Wei Liu, Baosheng Zeng, Guirong Wang, Dejun Hao, Yongping Huang
Olfaction plays an essential role in many important insect behaviors such as feeding and reproduction. To detect olfactory stimuli, an odorant receptor co-receptor (Orco) is required. In this study, we deleted the Orco gene in the Lepidopteran model insect, Bombyx mori, using a binary transgene-based clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system. We initially generated somatic mutations in two targeted sites, from which we obtained homozygous mutants with deletion of a 866 base pair sequence...
July 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28490635/the-foxo-transcription-factor-controls-insect-growth-and-development-by-regulating-juvenile-hormone-degradation-in-the-silkworm-bombyx-mori
#20
Baosheng Zeng, Yuping Huang, Jun Xu, Takahiro Shiotsuki, Hua Bai, Subba Reddy Palli, Yongping Huang, Anjiang Tan
Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. However, how FOXO interacts with hormone signaling to modulate insect growth and development is largely unknown. Here, using the transgene-based CRISPR/Cas9 system, we generated and characterized mutants of the silkworm Bombyx mori FOXO (BmFOXO) to elucidate its physiological functions during development of this lepidopteran insect...
July 14, 2017: Journal of Biological Chemistry
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