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https://www.readbyqxmd.com/read/28974887/circulating-inflammatory-factors-associated-with-worse-long-term-prognosis-in-colorectal-cancer
#1
Renate S Olsen, Johnny Nijm, Roland E Andersson, Jan Dimberg, Dick Wågsäter
AIM: To investigate association of circulating inflammatory factors at the time of colorectal cancer (CRC) surgery with survival. METHODS: Plasma levels from 174 CRC patients (69 females and 105 men), with median age 70 years (range 29-90), localized in the colon (n = 105) or rectum (n = 69), with stage I (n = 24), stage II (n = 54), stage III (n = 67) and stage IV (n = 29) were measured using commercially available Bio-Plex Pro™ Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28972436/chemokine-cxc-ligand-13-in-cerebrospinal-fluid-can-be-used-as-an-early-diagnostic-biomarker-for-lyme-neuroborreliosis-a-meta-analysis
#2
Jiaru Yang, Xinlin Han, Aihua Liu, Fukai Bao, Yun Peng, Lüyan Tao, Mingbiao Ma, Ruolan Bai, Xiting Dai
Lyme neuroborreliosis (LNB), which is the most common neurological manifestation of Lyme disease (LD), seriously impairs both the central and peripheral nervous systems. Current LNB diagnostic methods and criteria are not very effective. Recently, several studies have indicated that a high concentration of the chemokine CXC ligand 13 (CXCL13) in cerebrospinal fluid (CSF) could be used as a new biomarker for the diagnosis of LNB. Thus, we carried out a meta-analysis to systematically analyze the data from these studies to evaluate the value of CXCL13 as an LNB biomarker...
October 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28972011/effective-activated-pi3k%C3%AE-syndrome-targeted-therapy-with-the-pi3k%C3%AE-inhibitor-leniolisib
#3
V Koneti Rao, Sharon Webster, Virgil A S H Dalm, Anna Šedivá, P Martin van Hagen, Steven Holland, Sergio D Rosenzweig, Andreas D Christ, Birgitte Sloth, Maciej Cabanski, Aniket D Joshi, Stefan de Buck, Julie Doucet, Danilo Guerini, Christoph Kalis, Ilona Pylvaenaeinen, Nicolas Soldermann, Anuj Kashyap, Gulbu Uzel, Michael J Lenardo, Dhavalkumar D Patel, Carrie L Lucas, Christoph Burkhart
Pathogenic gain-of-function variants in the genes encoding PI3Kδ (phosphoinositide 3-kinase delta) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy and immune-deficiency (Activated PI3Kδ Syndrome, APDS). Knowing the genetic etiology of APDS afforded us the opportunity to explore PI3Kδ inhibition as a precision-medicine therapy. Here, we report in vitro and in vivo effects of inhibiting PI3Kδ in APDS. Treatment with leniolisib (CDZ173), a selective PI3Kδ inhibitor, caused a dose-dependent suppression of PI3Kδ pathway hyperactivation (measured as phosphorylation of AKT/S6) in cell lines ectopically expressing APDS-causative p110δ variants and in T cell blasts derived from patients...
September 29, 2017: Blood
https://www.readbyqxmd.com/read/28970832/use-of-toll-like-receptor-agonists-to-induce-ectopic-lymphoid-structures-in-myasthenia-gravis-mouse-models
#4
Marieke Robinet, Bérengère Villeret, Solène Maillard, Mélanie A Cron, Sonia Berrih-Aknin, Rozen Le Panse
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. MG symptoms are characterized by muscle weaknesses. The thymus of MG patients is very often abnormal and possesses all the characteristics of tertiary lymphoid organs such as neoangiogenesis processes, overexpression of inflammatory cytokines and chemokines, and infiltration of B lymphocytes leading to ectopic germinal center (GC) development. We previously demonstrated that injections of mice with polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic double-stranded RNA mimicking viral infection, induce thymic changes and trigger MG symptoms...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28945625/expression-of-tfh-markers-and-detection-of-rhoa-p-g17v-and-idh2-p-r172k-s-mutations-in-cutaneous-localizations-of-angioimmunoblastic-t-cell-lymphomas
#5
Ariane Leclaire Alirkilicarslan, Aurélie Dupuy, Anaïs Pujals, Marie Parrens, Béatrice Vergier, Alistair Robson, Marie-Hélène Delfau-Larue, Saskia Ingen-Housz-Oro, Olivier Chosidow, Corinne Haioun, Marie Beylot-Barry, Jean-Philippe Merlio, Christiane Copie-Bergman, Philippe Gaulard, Nicolas Ortonne
Skin biopsies of 41 angioimmunoblastic T-cell lymphoma patients were retrospectively analyzed for the expression of follicular helper T-cell (TFH) markers, Epstein-Barr virus (EBV), and the presence of RHOA (p.G17V) and IDH2 (p.R172K/S) mutations using allele-specific polymerase chain reaction. We categorized cases into 4 distinctive patterns: (1) low-density lymphocytic perivascular infiltrates (n=11), (2) dense perivascular infiltrates with atypical cells and occasional inflammatory cells (n=13), (3) diffuse infiltrates reminiscent of angioimmunoblastic T-cell lymphoma (n=4), or (4) other aspects (n=13)...
September 22, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28943879/plasma-cxcl13-but-not-b-cell-frequencies-in-acute-hiv-infection-predicts-emergence-of-cross-neutralizing-antibodies
#6
Jenniffer M Mabuka, Anne-Sophie Dugast, Daniel M Muema, Tarylee Reddy, Yathisha Ramlakhan, Zelda Euler, Nasreen Ismail, Amber Moodley, Krista L Dong, Lynn Morris, Bruce D Walker, Galit Alter, Thumbi Ndung'u
Immunological events in acute HIV-1 infection before peak viremia (hyperacute phase) may contribute to the development of broadly cross-neutralizing antibodies. Here, we used pre-infection and acute-infection peripheral blood mononuclear cells and plasma samples from 22 women, including 10 who initiated antiretroviral treatment in Fiebig stages I-V of acute infection to study B cell subsets and B-cell associated cytokines (BAFF and CXCL13) kinetics for up to ~90 days post detection of plasma viremia. Frequencies of B cell subsets were defined by flow cytometry while plasma cytokine levels were measured by ELISA...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28943543/expression-of-master-regulators-of-t-cell-helper-t-cell-and-follicular-helper-t-cell-differentiation-in-angioimmunoblastic-t-cell-lymphoma
#7
Yosuke Matsumoto, Hisao Nagoshi, Mihoko Yoshida, Seiichi Kato, Junya Kuroda, Kazuho Shimura, Hiroto Kaneko, Shigeo Horiike, Shigeo Nakamura, Masafumi Taniwaki
Objective It has been postulated that the normal counterpart of angioimmunoblastic T-cell lymphoma (AITL) is the follicular helper T-cell (TFH). Recent immunological studies have identified several transcription factors responsible for T-cell differentiation. The master regulators associated with T-cell, helper T-cell (Th), and TFH differentiation are reportedly BCL11B, Th-POK, and BCL6, respectively. We explored the postulated normal counterpart of AITL with respect to the expression of the master regulators of T-cell differentiation...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28931218/aberrant-humoral-immune-responses-in-neurosyphilis-cxcl13-cxcr5-play-a-pivotal-role-for-b-cell-recruitment-to-the-cerebrospinal-fluid
#8
Qian Yu, Yuanyuan Cheng, Yuanyuan Wang, Cuini Wang, Haikong Lu, Zhifang Guan, Jian Huang, Weiming Gong, Mei Shi, Liyan Ni, Juan Wu, Ruirui Peng, Pingyu Zhou
Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown. Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Expression of immunoglobulin indices and chemokine ligand CXCL13 was detected by enzyme-linked immunosorbent assay. The migration and inhibition assays were evaluated by modified chamber assays...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28886017/b-cell-phenotype-and-igd-cd27-memory-b-cells-are-affected-by-tnf-inhibitors-and-tocilizumab-treatment-in-rheumatoid-arthritis
#9
Rita A Moura, Cláudia Quaresma, Ana R Vieira, Maria J Gonçalves, Joaquim Polido-Pereira, Vasco C Romão, Nádia Martins, Helena Canhão, João E Fonseca
BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene expression in RA. METHODS: Blood samples were collected from untreated early RA (ERA) patients, established RA patients under methotrexate treatment, established RA patients before and after treatment with TNF-inhibitors and tocilizumab, and healthy donors...
2017: PloS One
https://www.readbyqxmd.com/read/28881808/cxcl13-is-androgen-responsive-and-involved-in-androgen-induced-prostate-cancer-cell-migration-and-invasion
#10
Long Fan, Qingyi Zhu, Li Liu, Cuicui Zhu, Haojie Huang, Shan Lu, Ping Liu
Androgen receptor (AR) is a key transcription factor playing a critical role in prostate cancer (PCa) initiation and progression. However, the molecular mechanisms of AR action in prostate cancer are not very clear. CXCL13, known as B cell attracting chemokine1 (BCA-1), is a member of CXC chemokine family and relevant to cancer metastasis. This study shows that CXCL13 is an androgen-responsive gene and involved in AR-induced PCa cell migration and invasion. In clinical specimens, expression of CXCL13 in PCa tissues is markedly higher than that in adjacent normal tissues...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28870573/cxcl10-and-cxcl13-chemokines-in-patients-with-relapsing-remitting-and-primary-progressive-multiple-sclerosis
#11
Piotr Iwanowski, Jacek Losy, Lucyna Kramer, Marlena Wójcicka, Elżbieta Kaufman
OBJECTIVES: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system characterized by a variable clinical course. Different pathogenic mechanisms responsible for relapsing remitting (RRMS) and primary progressive multiple sclerosis (PPMS) are modulated by immunological process with important role of chemokine network. CXCL10 and CXCL13 chemokines act as chemoattractants and modulators of proinflammatory reactions promoting process of demyelination...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28867633/borrelia-burgdorferi-basic-membrane-protein-a-could-induce-chemokine-production-in-murine-microglia-cell-line-bv2
#12
Hua Zhao, Aihua Liu, Yuhui Cui, Zhang Liang, Bingxue Li, Fukai Bao
Lyme neuroborreliosis is a nervous system infectious disease caused by Borrelia burgdorferi (B. burgdorferi). It has been demonstrated that cytokines induced by B. burgdorferi are related to Lyme neuroborreliosis. Microglia is known as a key player in the immune responses that occur within the central nervous system. In response to inflammation, it will be activated and generate cytokines and chemokines. Experiments in vitro cells have showed that B. Burgdorferi membrane protein A (BmpA), a major immunogen of B...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28859668/cerebrospinal-fluid-cxcl13-as-a-diagnostic-marker-of-neuroborreliosis-in-children-a-retrospective-case-control-study
#13
M M Remy, N Schöbi, L Kottanattu, S Pfister, A Duppenthaler, F Suter-Riniker
BACKGROUND: Lyme neuroborreliosis (LNB) is a frequent manifestation of Lyme disease in children and its current diagnosis has limitations. The elevation of the chemokine CXCL13 in the cerebrospinal fluid (CSF) of adult patients with LNB has been demonstrated and suggested as a new diagnostic marker. Our aim was to evaluate this marker in the CSF of children with suspected LNB and to determine a CXCL13 cut-off concentration that would discriminate between LNB and other central nervous system (CNS) infections...
August 31, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28831853/defining-active-progressive-multiple-sclerosis
#14
Finn Sellebjerg, Lars Börnsen, Cecilie Ammitzbøll, Jørgen Erik Nielsen, Tua Vinther-Jensen, Lena Elisabeth Hjermind, Marina von Essen, Rikke Lenhard Ratzer, Per Soelberg Sørensen, Jeppe Romme Christensen
BACKGROUND: It is unknown whether disease activity according to consensus criteria (magnetic resonance imaging activity or clinical relapses) associate with cerebrospinal fluid (CSF) changes in progressive multiple sclerosis (MS). OBJECTIVE: To compare CSF biomarkers in active and inactive progressive MS according to consensus criteria. METHODS: Neurofilament light chain (NFL), myelin basic protein (MBP), IgG-index, chitinase-3-like-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), chemokine CXCL13, terminal complement complex, leukocyte counts and nitric oxide metabolites were measured in primary ( n = 26) and secondary progressive MS ( n = 26) and healthy controls ( n = 24)...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28827754/t-follicular-helper-cells-and-antibody-response-to-hepatitis-b-virus-vaccine-in-hiv-1-infected-children-receiving-art
#15
Yonas Bekele, Desalegn Yibeltal, Kidist Bobosha, Temesgen E Andargie, Mahlet Lemma, Meseret Gebre, Eyasu Mekonnen, Abiy Habtewold, Anna Nilsson, Abraham Aseffa, Rawleigh Howe, Francesca Chiodi
HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedule of 4 weeks apart. At 1 month post-vaccination all children, except 4 HIV-1 infected, displayed protective antibody (ab) titers to HBV vaccine; ab titers were lower in infected children (P < 0.0001)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827539/t-cell-specific-cxcr5%C3%A2-deficiency-prevents-rheumatoid-arthritis
#16
Georgios L Moschovakis, Anja Bubke, Michaela Friedrichsen, Christine S Falk, Regina Feederle, Reinhold Förster
The chemokine receptor CXCR5 is primarily expressed on B cells and Tfh cells and facilitates their migration towards B cell follicles. In the present study we investigated the role of the CXCL13/CXCR5 axis in the pathogenesis of rheumatoid arthritis (RA) and specifically addressed the impact of CXCR5-mediated T and B cell migration in this disease. Employing collagen-induced arthritis (CIA) we identify CXCR5 as an absolutely essential factor for the induction of inflammatory autoimmune arthritis. Cxcr5-deficient mice and mice selectively lacking Cxcr5 on T cells were completely resistant to CIA, showed impaired germinal center responses and failed to mount an IgG1 antibody response to collagen II...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808159/chronic-brucella-infection-induces-selective-and-persistent-ifn-%C3%AE-dependent-alterations-of-marginal-zone-macrophages-in-the-spleen
#17
Arnaud Machelart, Abir Khadrawi, Aurore Demars, Kevin Willemart, Carl De Trez, Jean-Jacques Letesson, Eric Muraille
The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209(+) MZ macrophages (MZMs) and the CD169(+) marginal metallophilic macrophages (MMMs). Acute systemic infection strongly impacts MZ populations and the location of T and B lymphocytes. This phenomenon has been linked to reduced chemokine secretion by stromal cells. Brucella spp. are the causative agent of brucellosis, a widespread zoonotic disease. Here, we used B...
August 14, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28801669/balance-between-estrogens-and-proinflammatory-cytokines-regulates-chemokine-production-involved-in-thymic-germinal-center-formation
#18
Nadine Dragin, Patrice Nancy, José Villegas, Régine Roussin, Rozen Le Panse, Sonia Berrih-Aknin
The early-onset form of Myasthenia Gravis (MG) is prevalent in women and associates with ectopic germinal centers (GCs) development and inflammation in the thymus. we aimed to investigate the contribution of estrogens in the molecular processes involved in thymic GCs formation. We examined expression of genes involved in anti-acetylcholine receptor (AChR) response in MG, MHC class II and α-AChR subunit as well as chemokines involved in GC development (CXCL13, CCL21and CXCL12). In resting conditions, estrogens have strong regulatory effects on thymic epithelial cells (TECs), inducing a decreased protein expression of the above molecules...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798070/cxcl13-levels-are-elevated-in-patients-with-waldenstrom-s-macroglobulinemia-and-are-predictive-of-major-response-to-ibrutinib
#19
Josephine M Vos, Nickolas Tsakmaklis, Christopher J Patterson, Kirsten Meid, Jorge J Castillo, Philip Brodsky, Tomas Ganz, Steven T Pals, Marie José Kersten, Lian Xu, Guang Yang, Steven P Treon, Zachary R Hunter
No abstract text is available yet for this article.
August 10, 2017: Haematologica
https://www.readbyqxmd.com/read/28797085/comparison-of-cytokine-profiles-in-the-aqueous-humor-of-eyes-with-pseudoexfoliation-syndrome-and-glaucoma
#20
Justus G Garweg, Souska Zandi, Isabel B Pfister, Magdalena Skowronska, Christin Gerhardt
PURPOSE: To compare the cyto- and chemokine profiles in the aqueous humor of PEXS eyes in the absence or presence of secondary glaucoma with or without luxation of the intraocular lens (IOL). METHODS: Samples of aqueous humor were collected intraoperatively from 20 healthy controls and from 73 eyes with PEX-syndrome, which was manifested in the absence of any other local or systemic desease. The latter group was sub-devided into eyes with an early form of PEX-syndrome in the absence of complications (PEX, n = 33), those with a late form of PEX-syndrome and glaucoma (PEXG, n = 30), and those with a late form of PEX-syndrome with luxation of the IOL that required surgery (PEXL, n = 10)...
2017: PloS One
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