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https://www.readbyqxmd.com/read/28159893/dynamics-of-siv-specific-cxcr5-cd8-t-cells-during-chronic-siv-infection
#1
Geetha H Mylvaganam, Daniel Rios, Hadia M Abdelaal, Smita Iyer, Gregory Tharp, Maud Mavinger, Sakeenah Hicks, Ann Chahroudi, Rafi Ahmed, Steven E Bosinger, Ifor R Williams, Pamela J Skinner, Vijayakumar Velu, Rama R Amara
A significant challenge to HIV eradication is the elimination of viral reservoirs in germinal center (GC) T follicular helper (Tfh) cells. However, GCs are considered to be immune privileged for antiviral CD8 T cells. Here, we show a population of simian immunodeficiency virus (SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required for homing to GCs) and expand in lymph nodes (LNs) following pathogenic SIV infection in a cohort of vaccinated macaques. This expansion was greater in animals that exhibited superior control of SIV...
February 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28157399/cxcr5-cd8-t-cells-indirectly-offer-b-cell-help-and-are-inversely-correlated-with-viral-load-in-chronic-hepatitis-b-infection
#2
Hang Jiang, Linhai Li, Jiang Han, Zhiwei Sun, Yihui Rong, Yun Jin
Treatment options for chronic hepatitis B (CHB) infection are extremely limited. CXCR5(+) CD8(+) T cell is a novel cell subtype and could possess strong cytotoxic properties in HIV infection. In this study, we investigated the role of CXCR5(+) CD8(+) T cells in CHB patients. Compared to healthy individuals, both CHB patients and hepatitis B virus (HBV)-infected hepatocellular carcinoma patients presented significant upregulation of CXCR5(+) CD8(+) T cells in peripheral blood, in which CXCR5(+) CD8(+) T cells were negatively correlated with the frequency of CXCR5(+) CD4(+) T cells in CHB patients...
February 3, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28155010/chemokine-cxcl13-activates-p38-mapk-in-the-trigeminal-ganglion-after-infraorbital-nerve-injury
#3
Qian Zhang, Ming-Di Zhu, De-Li Cao, Xue-Qiang Bai, Yong-Jing Gao, Xiao-Bo Wu
Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive behavior in inflammatory or neuropathic pain. However, whether activation of p38 and JNK MAPK signaling pathway in the trigeminal ganglion (TG) are involved in CXCL13 and its receptor CXCR5-mediated orofacial pain has not yet been clarified...
February 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28150777/pathologically-expanded-peripheral-t-helper-cell-subset-drives-b-cells-in-rheumatoid-arthritis
#4
Deepak A Rao, Michael F Gurish, Jennifer L Marshall, Kamil Slowikowski, Chamith Y Fonseka, Yanyan Liu, Laura T Donlin, Lauren A Henderson, Kevin Wei, Fumitaka Mizoguchi, Nikola C Teslovich, Michael E Weinblatt, Elena M Massarotti, Jonathan S Coblyn, Simon M Helfgott, Yvonne C Lee, Derrick J Todd, Vivian P Bykerk, Susan M Goodman, Alessandra B Pernis, Lionel B Ivashkiv, Elizabeth W Karlson, Peter A Nigrovic, Andrew Filer, Christopher D Buckley, James A Lederer, Soumya Raychaudhuri, Michael B Brenner
CD4(+) T cells are central mediators of autoimmune pathology; however, defining their key effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4(+) T cells within affected tissues may be identified by expression of markers of recent activation. Here we use mass cytometry to analyse activated T cells in joint tissue from patients with rheumatoid arthritis, a chronic immune-mediated arthritis that affects up to 1% of the population. This approach revealed a markedly expanded population of PD-1(hi)CXCR5(-)CD4(+) T cells in synovium of patients with rheumatoid arthritis...
1, 2017: Nature
https://www.readbyqxmd.com/read/28138558/circulating-cxcr5-cxcr3-pd-1-lo-tfh-like-cells-in-hiv-1-controllers-with-neutralizing-antibody-breadth
#5
Enrique Martin-Gayo, Jacqueline Cronin, Taylor Hickman, Zhengyu Ouyang, Madelene Lindqvist, Kellie E Kolb, Julian Schulze Zur Wiesch, Rafael Cubas, Filippos Porichis, Alex K Shalek, Jan van Lunzen, Elias K Haddad, Bruce D Walker, Daniel E Kaufmann, Mathias Lichterfeld, Xu G Yu
HIV-1-specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the absence of high-level viremia may be important for designing bnAb-inducing immunogens. Here, we show that the breadth of neutralizing antibody responses in HIV-1 controllers was associated with a relative enrichment of circulating CXCR5(+)CXCR3(+)PD-1(lo) CD4(+) T cells...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28134081/detecting-novel-micro-rnas-in-rheumatoid-arthritis-with-gene-based-association-testing
#6
Aleksander Lenert, David W Fardo
OBJECTIVES: To identify novel risk genes by gene-based association analysis in rheumatoid arthritis (RA). METHODS: We performed gene-based association testing with GATES (Gene-based Association Test using Extended Simes procedure) to augment the power of genomewide-association study (GWAS) results from the largest meta-GWAS by Okada et al. in 14,361 RA cases and 43,923 controls of European ancestry using 8,694,488 SNPs. RESULTS: We identified 115 genes significantly associated with RA by gene-based association testing corresponding to 43 RA risk loci; 23 risk loci contained a single top risk gene, while 20 risk loci contained two or more risk genes...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28130496/induction-of-il21-in-peripheral-t-follicular-helper-cells-is-an-indicator-of-influenza-vaccine-response-in-a-previously-vaccinated-hiv-infected-pediatric-cohort
#7
Lesley R de Armas, Nicola Cotugno, Suresh Pallikkuth, Li Pan, Stefano Rinaldi, M Celeste Sanchez, Louis Gonzalez, Alberto Cagigi, Paolo Rossi, Paolo Palma, Savita Pahwa
HIV-infected patients of all ages frequently underperform in response to seasonal influenza vaccination, despite virologic control of HIV. The molecular mechanisms governing this impairment, as well as predictive biomarkers for responsiveness, remain unknown. This study was performed in samples obtained prevaccination (T0) from HIV-infected children who received the 2012-2013 seasonal influenza vaccine. Response status was determined based on established criterion for hemagglutination inhibition titer; participants with a hemagglutination titer ≥1:40 plus a ≥4-fold increase over T0 at 3 wk postvaccination were designated as responders...
January 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28126665/profiling-of-jejunum-inflammatory-gene-expression-during-murine-eimeriosis
#8
Mohamed A Dkhil, Mona Khalil, Saleh Al-Quraishy
To understand the host-parasite relationship during coccidiosis it is necessary to identify the transcriptional profile of the local host. In this study, gene profiling in the mouse jejunum due to infection with Eimeria papillata was investigated using Agilent microarray technology. On day 5 post-infection, the characterization of infected and non-infected mice jejunum transcriptional response was compared. There was an increase in the level of tumour necrosis factor-α, nitrite/nitrate and nitric oxide synthase activity was observed following infection...
January 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28122164/increased-circulating-cxcr5-cd4-t-follicular-helper-like-cells-in-oral-lichen-planus
#9
Ya-Qin Tan, Qing Li, Jing Zhang, Ge-Fei Du, Rui Lu, Gang Zhou
BACKGROUND: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated...
January 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28112376/increased-frequency-of-peripheral-blood-follicular-helper-t-cells-and-elevated-serum-il%C3%A2-21-levels-in-patients-with-knee-osteoarthritis
#10
Yuxing Shan, Changlin Qi, Yijun Liu, Hui Gao, Ding Zhao, Yanfang Jiang
An aberrant immune response has been implicated in the pathogenesis of osteoarthritis (OA). However, the role of peripheral blood follicular helper T (TFH) cells in the pathogenesis of OA has yet to be elucidated. The purpose of the present study was to examine the role of TFH cells and serum interleukin‑21 (IL‑21) in the pathogenesis of OA. Frequency of peripheral blood inducible costimulator (ICOS)+, programmed death 1 (PD‑1)+, and IL‑21+ CXCR5+CD4+ T cells in 40 patients with OA and 13 healthy controls (HCs) were examined by flow cytometry...
January 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28108610/circulating-cxcr5-pd-1-icos-follicular-t-helper-cells-are-increased-close-to-the-diagnosis-of-type-1-diabetes-in-children-with-multiple-autoantibodies
#11
Tyyne Viisanen, Emmi-Leena Ihantola, Kirsti Näntö-Salonen, Heikki Hyöty, Noora Nurminen, Jenni Selvenius, Auni Juutilainen, Leena Moilanen, Jussi Pihlajamäki, Riitta Veijola, Jorma Toppari, Mikael Knip, Jorma Ilonen, Tuure Kinnunen
Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4(+)CXCR5(+) follicular T helper cells (Tfh). In this study, we have comprehensively characterized the Tfh- as well as B-cell compartments in a large cohort of children with newly diagnosed T1D or at different stages of preclinical T1D...
February 2017: Diabetes
https://www.readbyqxmd.com/read/28017425/vaccination-of-rhesus-macaques-with-the-live-attenuated-hsv-1-vaccine-vc2-stimulates-the-proliferation-of-mucosal-t-cells-and-germinal-center-responses-resulting-in-sustained-production-of-highly-neutralizing-antibodies
#12
Brent A Stanfield, Bapi Pahar, Vladimir N Chouljenko, Ronald Veazey, Konstantin G Kousoulas
We have shown that the live-attenuated HSV-1 VC2 vaccine strain with mutations in glycoprotein K (gK) and the membrane protein UL20 is unable to establish latency in vaccinated animals and produces a robust immune response capable of completely protecting mice against lethal vaginal HSV-1 or HSV-2 infections. To better understand the immune response generated by vaccination with VC2, we tested its ability to elicit immune responses in rhesus macaques. Vaccinated animals showed no signs of disease and developed increasing HSV-1 and HSV-2 reactive IgG1 after two booster vaccinations, while IgG subtypes IgG2 and IgG3 remained at low to undetectable levels...
January 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28004828/analysis-of-cxcr5-th17-cells-in-relation-to-disease-activity-and-tnf-inhibitor-therapy-in-rheumatoid-arthritis
#13
Deepika Singh, Matthew Henkel, Bernadette Sendon, June Feng, Anthony Fabio, Diana Metes, Larry W Moreland, Mandy J McGeachy
Th17 and TfH cells are thought to promote tissue inflammation and autoantibody production, respectively, in autoimmune diseases including rheumatoid arthritis (RA). TfH cells that co-express Th17 markers (CXCR5(+)Th17) encompass both of these pathogenic functions, and are increased in some human autoimmune settings including juvenile dermatomyositis. We investigated CXCR5(+)Th17 cells in RA subjects with stable or active disease and before and after TNF inhibitor therapy. CXCR5(+)Th17 cell frequency was increased in RA compared to healthy controls, but other helper T cell subsets were not different...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28002487/long-term-transcriptomic-effects-of-prebiotics-and-synbiotics-delivered-in-ovo-in-broiler-chickens
#14
Anna Slawinska, Arkadiusz Plowiec, Maria Siwek, Marcin Jaroszewski, Marek Bednarczyk
In ovo delivery of prebiotics and synbiotics in chickens allows for the development of intestinal microflora prior to hatching, which boosts their robustness. The goal of this study was to determine the transcriptomic profile of the spleen (S), cecal tonsils (CT), and large intestine (LI) of adult chickens injected with prebiotics and synbiotics in ovo. On day 12 of embryo development, incubating eggs were injected with prebiotics: inulin alone (P1) or in combination with Lactococcus lactis subsp. lactis IBB2955 (S1), galactooligosaccharides (GOS) alone (P2) or in combination with Lactococcus lactis subsp...
2016: PloS One
https://www.readbyqxmd.com/read/27987497/-significance-of-different-t-follicular-helper-subsets-in-rheumatoid-arthritis
#15
X M Chen, J Li, X Y Zhang, Y B Jin, D Yu, X L Sun, L J Wu, J He, Z G Li
OBJECTIVE: To detect the expressions of T follicular helper (Tfh) subsets and T follicular helper effect memory (Tfhem) cells in circulation of patients with rheumatoid arthritis (RA), as well as to examine their roles in providing biomarkers for active RA. METHODS: This study enrolled 41 patients with RA, who were navely-treated or had no application of hormone and disease-modifying anti-rheumatic drugs in recent 3 months, as well as 32 healthy controls. The percentages of Tfhem (CD4(+)CXCR5(+)CCR7(low)PD1(high)) cells, Tfh (CD3(+)CD4(+)CXCR5(+)CD45RA(-)) subsets, Tfh1 (CXCR3(+)CCR6(-)Tfh),Tfh2 (CXCR3(-)CCR6(-)Tfh),and Tfh17 (CXCR3(-)CCR6(+)Tfh), were determined by flow cytometry of peripheral blood from the patients with RA and health controls...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27987496/-detection-of-peripheral-follicular-helper-t-cells-in-rheumatoid-arthritis
#16
L M An, J Li, L L Ji, G T Li, Z L Zhang
OBJECTIVE: To detect cell frequency and surface markers of peripheral CD4(+)CXCR5+ follicular helper T (Tfh) cells and analyze the correlation between CD4(+)CXCR5(+)Tfh cells and rheumatoid arthritis (RA) disease activity. METHODS: Forty RA patients meeting the American College of Rheumatology classification criteria for RA and twenty healthy controls (HC) were included. The peripheral blood mononuclear cells and sera were collected. The expressions of CD4+CXCR5(+)Tfh cells (CXCR5, C-X-C chemokine receptor type 5) and inducible T cell costimulator (ICOS), programmed death 1 positive (PD-1), interleukin-21 receptor (IL-21R) and CD40 ligand (CD40L) positive on CD4(+)CXCR5(+)Tfh cells were analyzed by flow cytometry...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27957330/evidence-of-perturbed-germinal-center-dynamics-but-preserved-antibody-diversity-in-end-stage-renal-disease
#17
Kristian Assing, Christian Nielsen, Marianne Jakobsen, Alexandra Scholze, Mads Nybo, Grete Soerensen, Sussie Mortensen, Knud Vejen, Torben Barington, Claus Bistrup
INTRODUCTION: End-stage renal disease (ESRD) is associated with increased infectious susceptibility and with reduced vaccine responses consistent with compromised humoral immunity. Whether the compromised humoral immunity is due to reduced antibody diversity (reduced somatic hypermutation [SHM]) or altered germinal center (GC) dynamics is not known. The GC-derived chemokine CXCL13 as well as peripheral T follicular helper cells (pTFH) reflect GC dynamics, but have, similar to SHM, never been characterized in relation to ESRD...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27941331/interleukin-17ra-promotes-humoral-responses-and-glomerular-injury-in-experimental-rapidly-progressive-glomerulonephritis
#18
Joanna R Ghali, Kim M O'Sullivan, Peter J Eggenhuizen, Stephen R Holdsworth, A Richard Kitching
BACKGROUND/AIMS: Interleukin (IL)-17A and IL-17F are proinflammatory cytokines, which signal through a receptor complex consisting of IL-17RA and IL-17RC subunits. We sought to define the role of IL-17RA expression by leukocytes and stromal cells in nephritogenic immunity and injury in experimental glomerulonephritis. METHODS: Glomerulonephritis was induced in wild-type and IL-17RA-deficient (IL-17RA-/-) mice by sheep anti-mouse glomerular basement membrane globulin...
December 10, 2016: Nephron
https://www.readbyqxmd.com/read/27933060/regulators-of-tfh-cell-differentiation
#19
REVIEW
Gajendra M Jogdand, Suchitra Mohanty, Satish Devadas
The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in clearing infections and are adversely linked with autoimmune diseases and also have a role in viral replication as well as clearance. On the one hand, Tfh cells are generated from naive CD4(+) T cells with sequential steps involving cytokine signaling (IL-21, IL-6, IL-12, activin A), migration, and positioning in the GC by CXCR5, surface receptors (ICOS/ICOSL, signaling lymphocyte activation molecule-associated protein/signaling lymphocyte activation molecule) as well as transcription factor (BCL-6, c-Maf, and signal transducer and activator of transcription 3) signaling and repressor miR155...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27931292/circulating-follicular-t-helper-cell-subset-distribution-in-patients-with-asthma
#20
Fang Gong, Chunyan Qian, HuaYan Zhu, Jie Zhu, Yuhong Pan, QiaoJing Dong, DongLin Jiang
BACKGROUND: The pathogenesis of allergic asthma is primarily characterized by abnormality in the immunoglobulin E (IgE) pathway, suggesting a possible role for follicular T-helper cells (Tfh) in the genesis of excessive IgE accumulation. The blood chemokine (C-X-C motif) receptor 5 (CXCR5)+CD4+ T cells, known as circulating Tfh, share common functional characteristics with Tfh cells from germinal centers. There are three subsets of circulating Tfh cells: Tfh1 (CXCR3+CC chemokine receptor [CCR] 6), Tfh2 (CXCR3CCR6) and Tfh17 (CXCR3CCR6+)...
November 2016: Allergy and Asthma Proceedings:
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