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https://www.readbyqxmd.com/read/29781221/aberrant-expansion-and-function-of-t-follicular-helper-cell-subsets-in-igg4-related-disease
#1
Yu Chen, Wei Lin, Hongxian Yang, Mu Wang, Panpan Zhang, Ruie Feng, Hua Chen, Linyi Peng, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Wen Zhang, Peter E Lipsky
OBJECTIVE: To determine the number and function of Tfh cell subsets in IgG4-RD. METHODS: Mononuclear cells from peripheral blood and involved tissues of IgG4-RD patients were collected. Tfh cell subsets, mRNA levels of Bcl-6, Blimp-1 and IL-21 were tested. Immunohistochemistry and immunofluorescence techniques were used to assess the location of IL-21, Bcl-6, and (CD4+CXCR5+) Tfh cells in the involved tissues. Furthermore, by in vitro cell co-culture, the abilities of cTfh cell subsets to induce B cells proliferation, apoptosis, differentiation, and production of IgG4 were explored...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29743314/cd8-follicular-t-cells-promote-b-cell-antibody-class-switch-in-autoimmune-disease
#2
Kristen M Valentine, Dan Davini, Travis J Lawrence, Genevieve N Mullins, Miguel Manansala, Mufadhal Al-Kuhlani, James M Pinney, Jason K Davis, Anna E Beaudin, Suzanne S Sindi, David M Gravano, Katrina K Hoyer
CD8 T cells can play both a protective and pathogenic role in inflammation and autoimmune development. Recent studies have highlighted the ability of CD8 T cells to function as T follicular helper (Tfh) cells in the germinal center in the context of infection. However, whether this phenomenon occurs in autoimmunity and contributes to autoimmune pathogenesis is largely unexplored. In this study, we show that CD8 T cells acquire a CD4 Tfh profile in the absence of functional regulatory T cells in both the IL-2-deficient and scurfy mouse models...
May 9, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29739909/a-high-frequency-of-hiv-specific-circulating-follicular-helper-t-cells-is-associated-with-preserved-memory-b-cell-responses-in-hiv-controllers
#3
M Claireaux, M Galperin, D Benati, A Nouël, M Mukhopadhyay, J Klingler, P de Truchis, D Zucman, S Hendou, F Boufassa, C Moog, O Lambotte, L A Chakrabarti
Follicular helper T cells (Tfh) play an essential role in the affinity maturation of the antibody response by providing help to B cells. To determine whether this CD4+ T cell subset may contribute to the spontaneous control of HIV infection, we analyzed the phenotype and function of circulating Tfh (cTfh) in patients from the ANRS CO21 CODEX cohort who naturally controlled HIV-1 replication to undetectable levels and compared them to treated patients with similarly low viral loads. HIV-specific cTfh (Tet+ ), detected by Gag-major histocompatibility complex class II (MHC-II) tetramer labeling in the CD45RA- CXCR5+ CD4+ T cell population, proved more frequent in the controller group ( P = 0...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29731839/high-frequency-of-circulating-follicular-helper-t-cells-is-correlated-with-b-cell-subtypes-in-patients-with-ankylosing-spondylitis
#4
Siqi Long, Li Ma, Dongsheng Wang, Xianwen Shang
T follicular helper (Tfh) cells are known to support effector B cells and enhance autoimmunity; however, the association between the Tfh cells and B cells in ankylosing spondylitis (AS) is unclear. The aim of the present study was to measure the frequency of circulating cluster of differentiation (CD)4+ C-X-C chemokine receptor type 5 (CXCR5)+ Tfh cells and B cell subtypes in peripheral blood from patients with AS, and evaluate the correlation of these factors. Percentages of peripheral blood circulating CD4+ CXCR5+ Tfh cells and B cell subtypes were measured via flow cytometry and the disease activity of individual patients was measured using the Bath AS Disease Activity Index (BASDAI)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29698707/distinct-characteristics-of-hippocampal-pathogenic-t-h-17-cells-in-a-mouse-model-of-depression
#5
Eléonore Beurel, Jeffrey Lowell, Richard Jope
Increasing evidence indicates that multiple actions of the immune system are closely intertwined with the development of depression and subsequent recovery processes. One of these interactions is substantial evidence that the TH 17 subtype of CD4+ T cells promotes susceptibility to depression-like behaviors in rodents. Comparing subtypes of CD4+ T cells, we found that administration of TH 17 cells, but not TH 1 cells or TREGS , promoted susceptibility to learned-helplessness depressive-like behavior and accumulated in the hippocampus of learned helpless mice...
April 23, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29694256/associations-of-circulating-cxcr3-pd-1-cd4-t-cells-with-disease-activity-of-systemic-lupus-erythematosus
#6
Han Lei, Yang Xue, Yu Yiyun, Wan Weiguo, Lv Ling, Hejian Zou
OBJECTIVES: Which helper CD4+ T cell subset contributes to autoantibodies generation and severity of end-organ involvement in lupus patients remains to be explored. Our research aims to investigate the roles of circulating Tfh (cTfh) cell subsets and corresponding CXCR5- Th cells in lupus patients and their correlation with SLEDAI. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from blood of SLE patients as well as healthy donors. The proportion of Th cell Subsets classified from cell surface markers (CD45RO, CXCR5, CXCR3, CCR6, PD-1, ICOS, and CCR7) is detected by flow cytometry...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29683413/increased-circulating-follicular-regulatory-t-like-cells-may-play-a-critical-role-in-chronic-hepatitis-b-virus-infection-and-disease-progression
#7
Xiaojuan Wu, Zhenzhen Su, Bei Cai, Lin Yan, Yamei Li, Weihua Feng, Lanlan Wang
Follicular helper T cells (TFH) and follicular regulatory T cells (TFR), subsets of T cells, co-regulate the reactions of germinal center (GC) B cells. TFH provide help to the GC response, while the TFR suppress those processes. Nevertheless, the role of circulating TFR (cTFR) and circulating TFH (cTFH) in chronic hepatitis B virus (HBV) infection remains limited. Twenty healthy controls (HCs), 24 patients with chronic hepatitis B (CHB), 23 with HBV-related liver cirrhosis (LC), and 18 with HBV-related hepatocellular carcinoma were enrolled in our study between October 2015 and September 2016...
April 23, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29670614/human-v%C3%AE-9v%C3%AE-2-t-cells-synergize-cd4-t-follicular-helper-cells-to-produce-influenza-virus-specific-antibody
#8
Qingyun Chen, Kun Wen, Aizhen Lv, Ming Liu, Ke Ni, Zheng Xiang, Yinping Liu, Wenwei Tu
Human Vγ9Vδ2-T cells recognize nonpeptidic antigens and exert effector functions against microorganisms and tumors, but little is known about their roles in humoral immune response against influenza virus infection. Herein, in the coculture of autologous human B cells, dendritic cells and/or naïve CD4 T cells, and Vγ9Vδ2-T cells, we demonstrated that Vγ9Vδ2-T cells could facilitate H9N2 influenza virus-specific IgG and IgM productions in a CD4 T cell-dependent manner. Vγ9Vδ2-T cells promoted the differentiation of CXCR5+ PD1+ CD4+ T follicular helper (Tfh) cells, CD19+ IgD- CD38++ plasma cells (PCs), and drove B cell proliferation as well as immunoglobulin class switching...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29652652/circulating-follicular-helper-t-cells-cd4-cxcr5-icos-decrease-in-patients-with-rheumatoid-arthritis-treated-with-abatacept
#9
Silvia Piantoni, Francesca Regola, Mirko Scarsi, Angela Tincani, Paolo Airò
No abstract text is available yet for this article.
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29649077/circulating-cxcr5-expressing-cd8-t-cells-are-major-producers-of-il-21-and-associate-with-limited-hiv-replication
#10
Federico Perdomo-Celis, Natalia A Taborda, Maria T Rugeles
BACKGROUND: Despite advances made with the highly active anti-retroviral therapy (HAART) in the control of the human immunodeficiency virus 1 (HIV) infection, a cure has not been achieved due to the persistence of viral reservoirs. The major HIV reservoirs remain in the lymphoid follicles due to, among other factors, the partial absence of CD8T-cells in these structures. Recently, lymphoid follicle-confined and circulating CD8T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, possessing antiviral mechanisms which could help to control HIV replication...
April 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29617174/prolonged-follicular-helper-t-cell-responses-in-me7-scrapie-infected-mice
#11
Soochan Kim, Sinsuk Han, Taehyun Kim, Jeehoon Nam, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Kim
We previously reported that mice intracerebrally inoculated with the mouse-adapted scrapie strain ME7 have markedly diminished T zones in the spleen due to the decreased expression of CCL19 and CCL21. In addition, follicular dendritic cell networks in germinal centers were larger in ME7-infected spleens compared to uninfected spleens. As an extension of that study, we set out to determine how ME7 infection affects spleen structure and follicular helper T (Tfh) cell responses in mice. For this study, mice were intraperitoneally inoculated with brain homogenate of the ME7 inoculum and spleens were analyzed 50, 130, and 200 days after inoculation and compared with those from uninfected mice...
April 4, 2018: Prion
https://www.readbyqxmd.com/read/29616024/simian-immunodeficiency-virus-siv-specific-chimeric-antigen-receptor-t-cells-engineered-to-target-b-cell-follicles-and-suppress-siv-replication
#12
Kumudhini Preethi Haran, Agnes Hajduczki, Mary S Pampusch, Gwantwa Mwakalundwa, Diego A Vargas-Inchaustegui, Eva G Rakasz, Elizabeth Connick, Edward A Berger, Pamela J Skinner
There is a need to develop improved methods to treat and potentially cure HIV infection. During chronic HIV infection, replication is concentrated within T follicular helper cells (Tfh) located within B cell follicles, where low levels of virus-specific CTL permit ongoing viral replication. We previously showed that elevated levels of simian immunodeficiency virus (SIV)-specific CTL in B cell follicles are linked to both decreased levels of viral replication in follicles and decreased plasma viral loads. These findings provide the rationale to develop a strategy for targeting follicular viral-producing (Tfh) cells using antiviral chimeric antigen receptor (CAR) T cells co-expressing the follicular homing chemokine receptor CXCR5...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29614336/peripheral-blood-immune-response-related-gene-analysis-for-evaluating-the-potential-risk-of-chronic-antibody-mediated-rejection
#13
Takayuki Yamamoto, Kenta Iwasaki, Kenta Murotani, Asami Takeda, Kenta Futamura, Manabu Okada, Makoto Tsujita, Takahisa Hiramitsu, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Kunio Morozumi, Kazuharu Uchida, Takaaki Kobayashi
Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA). This study aimed to elucidate the clinical relevance of immune-related gene expression in peripheral blood of kidney transplant recipients. The expression levels of fourteen key molecules (Foxp3, CTLA-4, CCR7, TGF-β, IGLL-1, IL-10, ITCH, CBLB, Bcl-6, CXCR5, granzyme B, CIITA, Baff, TOAG-1/TCAIM) related to regulatory/cytotoxic function of immune cells were compared in 93 patients, which were divided into Groups A (clinical cAMR with dn DSA, n=16), B (subclinical cAMR with dn DSA, n=17), C (negative cAMR with dn DSA, n=21) and D (stable function without dn DSA, n=39)...
March 31, 2018: Human Immunology
https://www.readbyqxmd.com/read/29595664/roles-of-t-follicular-helper-cells-in-the-pathogenesis-of-adenoidal-hypertrophy-combined-with-secretory-otitis-media
#14
Chunyan Feng, Qicheng Zhang, Guangquan Zhou, Jing Zhang, Yanshu Zhang
The aim of this study was to investigate the roles of T follicular helper (Tfh) cells in secretory otitis media (SOM) combined with adenoidal hypertrophy (AH).Patients with AH or AH combined with SOM admitted to the Yancheng No. 1 People's Hospital from December 2012 to December 2014 were included. Fourteen age-matched healthy individuals received physical examinations in the hospital served as control. The venous Tfh was determined using flow cytometry, and CD3 + CD4 + CXCR5 + T lymphocytes were defined as Tfh cells...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29551031/-brain-derived-neurotrophic-factor-enhances-the-role-of-mesenchymal-stem-cells-in-inhibiting-follicular-helper-t-cells
#15
S N Yang, X Pu, S L Xiang, J P Chen, L Pei
Objective: To investigate the effect of brain derived neurotrophic factor (BDNF) on mesenchymal stem cells (MSC) inhibiting follicular helper T cells (Tfh cells). Methods: The contents of indoleamine 2,3-dioxygenase (IDO), IL-10, TGF-β and IL-21 in MSC culture supernatant were detected by ELISA; The peripheral blood of healthy volunteers were collected, and lymphocyte in peripheral blood was separated by human lymphocyte separation solution; Co-cultures of MSC and lymphocyte were performed by Transwell chamber, and the proportion of CD4(+)CXCR5(+) Tfh cells and their subtypes were detected by flow cytometry...
January 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29550578/non-obese-type-2-diabetes-patients-present-intestinal-b-cell-dysregulations-associated-with-hyperactive-intestinal-tfh-cells
#16
Jingjing Zhou, Yiran Wang, Yifei He, Ye Gao, Renhui Wan, Mengxi Cai, Wenwen Li, Rong Chen, Emma Walker, Xiao Zhai, Qijin Wang
Most current studies of type 2 diabetes (T2D) focus on obesity in the pathogenesis of the disease. However, many individuals develop T2D at non-obese body mass index (BMI) level. It is yet unclear whether certain etiological mechanisms discovered in these obese models can apply to non-obese T2D patients. In the present study, we focused on one aspect that was potentially involved in T2D development, the intestinal inflammation, and examined the difference between non-obese T2D patients and BMI-matched healthy controls...
May 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29544815/cd8-cxcr5-t-cells-in-tumor-draining-lymph-nodes-are-highly-activated-and-predict-better-prognosis-in-colorectal-cancer
#17
Jifu E, Feihu Yan, Zhengchun Kang, Liangliang Zhu, Junjie Xing, Enda Yu
Tumor-draining lymph nodes (TDLNs) are the primary sites of tumor antigen presentation, as well as the origin of metastasis in most cases. Hence, the type and function of immune cells in TDLNs are critical to the microenvironment and potentially affect the clinical outcome of the malignancy. CD8+ CXCR5+ T cells are recently described to present high effector functions in infectious diseases, but their role in colorectal cancer (CRC) remains unclear. In forty-four Stage III CRC patients, we examined the CD8+ CXCR5+ T cells in blood, tumor, and TDLN...
June 2018: Human Immunology
https://www.readbyqxmd.com/read/29535739/role-of-tfh-cells-in-promoting-t-helper-17-induced-neuroinflammation
#18
James L Quinn, Gaurav Kumar, Agnieshka Agasing, Rose M Ko, Robert C Axtell
Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how these cells cooperate to drive disease remains unclear. Recent studies using experimental autoimmune encephalomyelitis (EAE) demonstrated that the TH17 pathway is correlated with increased numbers of ectopic B-cell follicles in the central nervous system (CNS). As follicular T helper (TFH) cells are regulators of B cell responses, we sought to examine the role of TFH cells in EAE induced by the transfer of myelin-specific TH17 cells (TH17-EAE)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29535724/t-cell-subsets-in-the-germinal-center-lessons-from-the-macaque-model
#19
REVIEW
Monica Vaccari, Genoveffa Franchini
Germinal centers (GCs) are organized lymphoid tissue microstructures where B cells proliferate and differentiate into memory B cells and plasma cells. A few distinctive subsets of highly specialized T cells gain access to the GCs by expressing the B cell zone-homing C-X-C chemokine receptor type 5 (CXCR5) while losing the T cell zone-homing chemokine receptor CCR7. Help from T cells is critical to induce B cell proliferation and somatic hyper mutation and to limit GC reactions. CD4+ T follicular helper (TFH ) cells required for the formation of GCs and for the generation of long-lived, high-affinity B cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29526569/elevated-levels-of-follicular-t-helper-cells-and-their-association-with-therapeutic-effects-in-patients-with-chronic-lymphocytic-leukaemia
#20
Liannv Qiu, Yonglie Zhou, Qinhua Yu, Sujie Zheng, Zhenni Wang, Qiang Huang
Chronic lymphocytic leukaemia (CLL) is characterized by an abnormal expansion of mature B cells with variable progression. Follicular T helper (Tfh) cells help B cells differentiate into plasma cells or long-lived memory B cells in germinal centres (GCs). However, the role of Tfh cells in CLL is poorly understand, and whether it plays a critical role in disease progression in vivo is lacking. In this study, we investigate the dynamic change of circulating Tfh cells in peripheral blood from patients with CLL during the treatment periods to evaluate their utility to predict disease progression...
May 2018: Immunology Letters
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