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Journal of Reproduction and Development

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https://www.readbyqxmd.com/read/28966165/first-person-yi-wen-xu
#1
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Yi-Wen Xu is the first author on 'Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice', published in Journal of Cell Science. Yi-Wen is a PhD student in the lab of Heng-Yu Fan at the Life Sciences Institute, Zhejiang University, China, investigating the mechanisms of mammalian germ cell development and disease models relating to the female reproductive system...
October 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28939582/a-randomised-controlled-trial-of-an-intervention-delivered-by-app-instant-messaging-to-increase-the-acceptability-of-effective-contraception-among-young-people-in-tajikistan-study-protocol
#2
Ona McCarthy, Baptiste Leurent, Phil Edwards, Ravshan Tokhirov, Caroline Free
INTRODUCTION: Women in lower income countries experience unintended pregnancies at a higher rate compared with women in higher income countries. Unintended pregnancy is associated with numerous poorer health outcomes for both women and their children. In Tajikistan, an estimated 26% of married individuals aged 15-24 years have an unmet need for contraception. The strong cultural value placed on childbearing and oppositional attitudes towards contraception are major barriers to contraceptive uptake in the country...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28910998/abnormal-uterine-bleeding
#3
Ying Cheong, Iain T Cameron, Hilary O D Critchley
Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised, taking into account the improvement of the woman's symptoms and quality of life. Sources of data: Peer-reviewed journals, governmental and professional society publications. Areas of agreement: There is now agreement on a structured, universal approach to the diagnosis of AUB, with the aide memoirs PALM (polyps, adenomyosis, leiomyoma, malignancy) and COEIN (coagulopathies, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified)...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28872683/phytochemistry-and-pharmacological-potential-of-cassia-absus-a-review
#4
REVIEW
Saeed Ahmad, Ayesha Hassan, Waheed Mumtaz Abbasi, Tayyeba Rehman
OBJECTIVES: Cassia absus is a plant of the family fabaceae with Ayurvedic ethnomedical records. It is used in traditional medicine for the treatment of bronchitis, asthma, cough, conjunctivitis, leucoderma, renal and hepatic diseases, constipation, tumors, venereal ulcer, headache, hemorrhoids and wound healing. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its use. This review aims to summarize reported pharmacognosy, traditional uses, phytochemistry and pharmacological potential of C...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28854593/gynaecologists-and-industry-ain-t-no-sunshine
#5
Cynthia M Farquhar, Paolo Vercellini, Jane Marjoribanks
The field of reproductive medicine is known for its innovations, and where there is innovation there is marketing and engagement with the doctors who are potential prescribers and users of those innovations. Financial connections between drug and device manufacturers with doctors have been extensively debated over the past decade. On one hand, relationships between doctors and industry could be considered synergistic by allowing the development of improved treatments. On the other hand, payment (and other benefits) from industry to doctors may subtly shift the main objective of the collaboration from patients' health to mutual benefits for both doctors and industry...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28853925/sex-determination-in-the-mammalian-germline
#6
Cassy Spiller, Peter Koopman, Josephine Bowles
Sexual reproduction crucially depends on the production of sperm in males and oocytes in females. Both types of gamete arise from the same precursor, the germ cells. We review the events that characterize the development of germ cells during fetal life as they commit to, and prepare for, oogenesis or spermatogenesis. In females, fetal germ cells enter meiosis, whereas in males they delay meiosis and instead lose pluripotency, activate an irreversible program of prospermatogonial differentiation, and temporarily cease dividing...
August 30, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/28763097/obesity-and-adverse-breast-cancer-risk-and-outcome-mechanistic-insights-and-strategies-for-intervention
#7
REVIEW
Manuel Picon-Ruiz, Cynthia Morata-Tarifa, Janeiro J Valle-Goffin, Eitan R Friedman, Joyce M Slingerland
Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25-29.9 kg/m(2) ), and of these, over 600 million were obese (BMI ≥30 kg/m(2) ). Although the association between obesity and the risk of diabetes and coronary artery disease is widely known, the impact of obesity on cancer incidence, morbidity, and mortality is not fully appreciated...
September 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28736970/report-from-the-2016-university-of-california-san-francisco-center-for-reproductive-sciences-retreat
#8
Paolo F Rinaudo, Marco Conti
No abstract text is available yet for this article.
July 24, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28639335/a-systematic-review-on-identifying-risk-factors-associated-with-early-sexual-debut-and-coerced-sex-among-adolescents-and-young-people-in-communities
#9
REVIEW
Regina Lai Tong Lee, Alice Yuen Loke, Tsz Man Tommy Hung, Howard Sobel
AIM: To review literature on identifying the risk factors associated with early sexual coerced debut with the aim to facilitate the health care workers' planning of relevant health services to improve intervention strategies for delaying of early coerced sexual debut or forced sexual debut (CSD/FSD) in the communities. BACKGROUND: Identifying the risk factors associated with coercion at first sex is crucial for developing appropriate sexual and reproductive health information and health promotion in response...
June 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28561018/maternal-heterozygous-nlrp7-variant-results-in-recurrent-reproductive-failure-and-imprinting-disturbances-in-the-offspring
#10
Lukas Soellner, Matthias Begemann, Franziska Degenhardt, Annegret Geipel, Thomas Eggermann, Elisabeth Mangold
It has been shown previously that homozygous and compound-heterozygous variants affecting protein function in the human NLRP genes impact reproduction and/or fetal imprinting patterns. These variants represent so-called 'maternal effect mutations', that is, although female variant carriers are healthy, they are at risk of reproductive failure, and their offspring may develop aberrant methylation and imprinting disorders. In contrast, the relevance to reproductive failure of maternal heterozygous NLRP7 variants remains unclear...
August 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28489498/fusarium-oxysporum-and-the-fusarium-wilt-syndrome
#11
Thomas R Gordon
The Fusarium oxysporum species complex (FOSC) comprises a multitude of strains that cause vascular wilt diseases of economically important crops throughout the world. Although sexual reproduction is unknown in the FOSC, horizontal gene transfer may contribute to the observed diversity in pathogenic strains. Development of disease in a susceptible crop requires F. oxysporum to advance through a series of transitions, beginning with spore germination and culminating with establishment of a systemic infection...
August 4, 2017: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/28352118/body-composition-and-susceptibility-to-type-2-diabetes-an-evolutionary-perspective
#12
REVIEW
J C K Wells
Type 2 diabetes is rapidly increasing in prevalence worldwide, in concert with epidemics of obesity and sedentary behavior that are themselves tracking economic development. Within this broad pattern, susceptibility to diabetes varies substantially in association with ethnicity and nutritional exposures through the life-course. An evolutionary perspective may help understand why humans are so prone to this condition in modern environments, and why this risk is unequally distributed. A simple conceptual model treats diabetes risk as the function of two interacting traits, namely 'metabolic capacity' which promotes glucose homeostasis, and 'metabolic load' which challenges glucose homoeostasis...
July 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28294170/exploring-inter-organ-crosstalk-to-uncover-mechanisms-that-regulate-%C3%AE-cell-function-and-mass
#13
REVIEW
J Shirakawa, D F De Jesus, R N Kulkarni
Impaired β-cell function and insufficient β-cell mass compensation are twin pathogenic features that underlie type 2 diabetes (T2D). Current therapeutic strategies continue to evolve to improve treatment outcomes in different ethnic populations and include approaches to counter insulin resistance and improve β-cell function. Although the effects of insulin secretion on metabolic organs such as liver, skeletal muscle and adipose is directly relevant for improving glucose uptake and reduce hyperglycemia, the ability of pancreatic β-cells to crosstalk with multiple non-metabolic tissues is providing novel insights into potential opportunities for improving β-cell function and/or mass that could have beneficial effects in patients with diabetes...
March 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28289046/observational-study-of-the-development-and-evaluation-of-a-fertility-preservation-patient-decision-aid-for-teenage-and-adult-women-diagnosed-with-cancer-the-cancer-fertility-and-me-research-protocol
#14
G L Jones, J Hughes, N Mahmoodi, D Greenfield, G Brauten-Smith, J Skull, J Gath, D Yeomanson, E Baskind, J A Snowden, R M Jacques, G Velikova, K Collins, D Stark, R Phillips, S Lane, H L Bekker
INTRODUCTION: Women diagnosed with cancer and facing potentially sterilising cancer treatment have to make time-pressured decisions regarding fertility preservation with specialist fertility services while undergoing treatment of their cancer with oncology services. Oncologists identify a need for resources enabling them to support women's fertility preservation decisions more effectively; women report wanting more specialist information to make these decisions. The overall aim of the 'Cancer, Fertility and Me' study is to develop and evaluate a new evidence-based patient decision aid (PtDA) for women with any cancer considering fertility preservation to address this unmet need...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28275241/characterization-of-contiguous-gene-deletions-in-col4a6-and-col4a5-in-alport-syndrome-diffuse-leiomyomatosis
#15
Kandai Nozu, Shogo Minamikawa, Shiro Yamada, Masafumi Oka, Motoko Yanagita, Naoya Morisada, Shuichiro Fujinaga, China Nagano, Yoshimitsu Gotoh, Eihiko Takahashi, Takahiro Morishita, Tomohiko Yamamura, Takeshi Ninchoji, Hiroshi Kaito, Ichiro Morioka, Koichi Nakanishi, Igor Vorechovsky, Kazumoto Iijima
Alport syndrome-diffuse leiomyomatosis (AS-DL, OMIM: 308940) is a rare variant of the X-linked Alport syndrome that shows overgrowth of visceral smooth muscles in the gastrointestinal, respiratory and female reproductive tracts in addition to renal symptoms. AS-DL results from deletions that encompass the 5' ends of the COL4A5 and COL4A6 genes, but deletion breakpoints between COL4A5 and COL4A6 have been determined in only four cases. Here, we characterize deletion breakpoints in five AS-DL patients and show a contiguous COL4A6/COL4A5 deletion in each case...
July 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28208158/epidemiologic-factors-that-predict-long-term-survival-following-a-diagnosis-of-epithelial-ovarian-cancer
#16
Shana J Kim, Barry Rosen, Isabel Fan, Anna Ivanova, John R McLaughlin, Harvey Risch, Steven A Narod, Joanne Kotsopoulos
BACKGROUND: Various epidemiologic factors have been shown to influence the risk of ovarian cancer development. Given the high fatality associated with this disease, it is of interest to evaluate the association of prediagnostic hormonal, reproductive, and lifestyle exposures with ovarian cancer-specific survival. METHODS: We included 1421 patients with invasive epithelial ovarian cancer diagnosed in Ontario, Canada. Clinical information was obtained from medical records and prediagnostic exposure information was collected by telephone interview...
March 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28199168/my-scientific-journey-from-an-agrarian-start-to-an-academic-setting
#17
Janice M Bahr
This article is a combination of an autobiography and a review of outstanding research done by over 70 graduate students, postdoctoral fellows, and visiting scientists along with excellent collaborators during my over-40-year career as a professor of reproductive physiology at the University of Illinois, Urbana-Champaign. I have also shared thoughts on mentoring, how research has changed over the years, and the future of reproductive physiology. I provide the reader with a snapshot of the challenges faced by a woman eager to obtain a PhD under the guidance of renowned professors in the early 1970s and to be hired as the first woman, and the only permanent female faculty member, for more than 20 years on a faculty of 40 men...
February 8, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/28125290/molecular-characteristics-and-biological-functions-of-surface-active-and-surfactant-proteins
#18
REVIEW
Margaret Sunde, Chi L L Pham, Ann H Kwan
Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a wide range of organisms produce surface-active proteins and peptides that reduce surface and interfacial tension and mediate growth and development at these boundaries. Microorganisms produce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air boundaries, attachment to surfaces, predation, and improved bioavailability of hydrophobic substrates. Higher-order organisms produce surface-active proteins with a wide variety of functions, including the provision of protective foam environments for vulnerable reproductive stages, evaporative cooling, and gas exchange across airway membranes...
June 20, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28119529/physiologic-and-genetic-evidence-links-hemopexin-to-triglycerides-in-mice-and-humans
#19
H A Lawson, M Zayed, J P Wayhart, E Fabbrini, L Love-Gregory, S Klein, C F Semenkovich
BACKGROUND/OBJECTIVES: Elevated triglycerides predict insulin resistance and vascular disease in obesity, but how the inert triglyceride molecule is related to development of metabolic disease is unknown. To pursue novel potential mediators of triglyceride-associated metabolic disease, we used a forward genetics approach involving inbred mice and translated our findings to human subjects. SUBJECTS/METHODS: Hemopexin (HPX) was identified as a differentially expressed gene within a quantitative trait locus associated with serum triglycerides in an F16 advanced intercross between the LG/J and SM/J strains of mice...
April 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28117309/estrogen-receptor-ligands-a-review-2013-2015
#20
REVIEW
Shabnam Farzaneh, Afshin Zarghi
Estrogen receptors (ERs) are a group of compounds named for their importance in both menstrual and estrous reproductive cycles. They are involved in the regulation of various processes ranging from tissue growth maintenance to reproduction. Their action is mediated through ER nuclear receptors. Two subtypes of the estrogen receptor, ERα and ERβ, exist and exhibit distinct cellular and tissue distribution patterns. In humans, both receptor subtypes are expressed in many cells and tissues, and they control key physiological functions in various organ systems...
April 13, 2016: Scientia Pharmaceutica
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