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https://www.readbyqxmd.com/read/28632563/why-lumbar-artificial-disk-replacements-ladrs-fail
#1
Kenneth Pettine, Robert Ryu, Fernando Techy
STUDY DESIGN: A retrospective review of prospectively collected data. OBJECTIVE: To determine why artificial disk replacements (ADRs) fail by examining results of 91 patients in FDA studies performed at a single investigational device exemption (IDE) site with minimum 2-year follow-up. SUMMARY OF BACKGROUND DATA: Patients following lumbar ADR generally achieve their 24-month follow-up results at 3 months postoperatively. MATERIALS AND METHODS: Every patient undergoing ADR at 1 IDE site by 2 surgeons was evaluated for clinical success...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28605777/racial-differences-in-the-relationship-of-glucose-concentrations-and-hemoglobin-a1c-levels
#2
Richard M Bergenstal, Robin L Gal, Crystal G Connor, Rose Gubitosi-Klug, Davida Kruger, Beth A Olson, Steven M Willi, Grazia Aleppo, Ruth S Weinstock, Jamie Wood, Michael Rickels, Linda A DiMeglio, Kathleen E Bethin, Santica Marcovina, Andreana Tassopoulos, Sooji Lee, Elaine Massaro, Suzan Bzdick, Brian Ichihara, Eileen Markmann, Paul McGuigan, Stephanie Woerner, Michelle Ecker, Roy W Beck
Background: Debate exists as to whether the higher hemoglobin A1c (HbA1c) levels observed in black persons than in white persons are due to worse glycemic control or racial differences in the glycation of hemoglobin. Objective: To determine whether a racial difference exists in the relationship of mean glucose and HbA1c. Design: Prospective, 12-week observational study. Setting: 10 diabetes centers in the United States...
June 13, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28604205/web-review-preparing-for-hospital
#3
(no author information available yet)
What? Why? Children in Hospital is a charitable organisation founded in 2015 that has set up a website to prepare parents, carers and children for positive hospital experiences.
June 12, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28604084/an-initial-psychometric-evaluation-of-the-german-promis-v1-2-physical-function-item-bank-in-patients-with-a-wide-range-of-health-conditions
#4
Gregor Liegl, Matthias Rose, Helena Correia, H Felix Fischer, Sibel Kanlidere, Annett Mierke, Alexander Obbarius, Sandra Nolte
OBJECTIVES: To translate the PROMIS Physical Function (PF) item bank version 1.2 into German and to investigate psychometric properties of resulting full bank and seven derived short forms. DESIGN: Cross-sectional psychometric study. SETTING: Inpatient and outpatient clinics of the Department of Psychosomatic Medicine at Charité-Universitätsmedizin Berlin, Germany. SUBJECTS: A total of 10 adult patients with various chronic diseases participated in cognitive debriefing interviews...
June 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28602689/empathic-care-and-distress-predictive-brain-markers-and-dissociable-brain-systems
#5
Yoni K Ashar, Jessica R Andrews-Hanna, Sona Dimidjian, Tor D Wager
Encountering another's suffering can elicit both empathic distress and empathic care-the warm desire to affiliate. It remains unclear whether these two feelings can be accurately and differentially predicted from neural activity and to what extent their neural substrates can be distinguished. We developed fMRI markers predicting moment-by-moment intensity levels of care and distress intensity while participants (n = 66) listened to true biographies describing human suffering. Both markers' predictions correlated strongly with self-report in out-of-sample participants (r = 0...
May 30, 2017: Neuron
https://www.readbyqxmd.com/read/28595063/motivations-for-volunteers-in-food-rescue-nutrition
#6
T Y Mousa, J H Freeland-Graves
OBJECTIVE: A variety of organizations redistribute surplus food to low-income populations through food rescue nutrition. Why volunteers participate in these charitable organizations is unclear. The aim of this study is to document the participation and motivations of volunteers who are involved specifically in food rescue nutrition. STUDY DESIGN: A cross-sectional study was conducted in two phases. METHODS: In phase 1, a new instrument, Motivations to Volunteer Scale, was developed and validated in 40 participants (aged ≥18 years)...
June 5, 2017: Public Health
https://www.readbyqxmd.com/read/28592203/the-use-of-an-online-support-group-for-neuromuscular-disorders-a-thematic-analysis-of-message-postings
#7
Oonagh Meade, Heather Buchanan, Neil Coulson
PURPOSE: People affected by neuromuscular disorders can experience adverse psychosocial consequences and difficulties accessing information and support. Online support groups provide new opportunities for peer support. The aim of this study was to understand how contributors used the message board function of a newly available neuromuscular disorders online support group. METHODS: Message postings (n = 1951) from the first five months of the message board of a newly formed online support group for neuromuscular disorders hosted by a charitable organization were analyzed using inductive thematic analysis...
June 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28591673/the-windmill-technique-avoids-manual-removal-of-the-retained-placenta-a-new-solution-for-an-old-problem
#8
Larry Hinkson, Mia Amelie Suermann, Susan Hinkson, Wolfgang Henrich
OBJECTIVE: The primary objective is to assess the reduction in manual removal of placenta with the Windmill technique of placenta delivery in patients with retained placenta. DESIGN: The Windmill technique involves the application of continuous 360° umbilical cord traction and rotation in such a manner as to be perpendicular to the direction of the birth canal at the level of the introitus. This rotation through 360° is repeated slowly with movement akin to the motion of the blades of a windmill...
June 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28579623/reference-curve-for-the-mean-uterine-artery-pulsatility-index-in-singleton-pregnancies
#9
Alexander Weichert, Andreas Hagen, Michael Tchirikov, Ilka B Fuchs, Wolfgang Henrich, Michael Entezami
INTRODUCTION: Doppler sonography of the uterine artery (UA) is done to monitor pregnancies, because the detected flow patterns are useful to draw inferences about possible disorders of trophoblast invasion. Increased resistance in the UA is associated with an increased risk of preeclampsia and/or intrauterine growth restriction (IUGR) and perinatal mortality. In the absence of standardized figures, the normal ranges of the various available reference curves sometimes differ quite substantially from one another...
May 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28575207/moran-s-i-quantifies-spatio-temporal-pattern-formation-in-neural-imaging-data
#10
Christoph Schmal, Jihwan Myung, Hanspeter Herzel, Grigory Bordyugov
Motivation: Neural activities of the brain occur through the formation of spatio-temporal patterns. In recent years, macroscopic neural imaging techniques have produced a large body of data on these patterned activities, yet a numerical measure of spatio-temporal coherence has often been reduced to the global order parameter, which does not uncover the degree of spatial correlation. Here, we propose to use the spatial autocorrelation measure Moran's I, which can be applied to capture dynamic signatures of spatial organization...
May 31, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28573870/sleep-and-physical-activity-a-survey-of-people-with-inflammatory-arthritis-and-their-engagement-by-health-professionals-in-rheumatology-in-ireland
#11
Sean McKenna, Alan Donnelly, Alexander Fraser, Norelee Kennedy
PURPOSE: Sleep is important in maintaining the body's circadian rhythm and in maintaining health. Aim was to investigate sleep and physical activity among people who have inflammatory arthritis and their engagement with Health Professionals. MATERIALS AND METHODS: Members from a national charitable organisation for patients with arthritis and a national rheumatology health professionals society were invited to participate in separate cross-sectional surveys hosted on SurveyMonkey((R)TM)...
June 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28555442/-the-treatment-of-acute-secondary-peritonitis-a-retrospective-analysis-of-the-use-of-continuous-negative-pressure-therapy
#12
V Müller, G Koplin, J Pratschke, W Raue
BACKGROUND: Patients with acute secondary peritonitis often need relaparotomies and open abdominal lavages. Continuous negative pressure therapy seems to be beneficial. OBJECTIVES: Does the efficacy of the therapy depend on the continuous negative pressure system used? MATERIALS AND METHODS: A retrospective analysis was performed in the Chirurgische Klinik der Universitätsmedizin Berlin, Charité Campus Mitte, including all patients who underwent abdominal vacuum therapy between December 2013 and February 2015...
May 29, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28555331/chronic-non-cancer-pain-management-capacity-in-karachi
#13
REVIEW
S Fatima Lakha, Peter Pennefather, Mubina Agboatwala, Safia Zafar Siddique, Hanan E Badr, Angela Mailis-Gagnon
Chronic non-cancer pain (CNCP) affects people everywhere in the world, but people in developing countries have far less access to therapies that provide relief. There are often missed opportunities to implement these therapies. Karachi shares many characteristics with megacities of the global south and represents Pakistan in the global city league. This review informs readers about the availability of health management and pain services for CNCP in Karachi, and their comparability to those found in other global cities...
May 29, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28552937/philanthro-metrics-mining-multi-million-dollar-gifts
#14
Una O Osili, Jacqueline Ackerman, Chin Hua Kong, Robert P Light, Katy Börner
The Million Dollar List (MDL, online at http://www.milliondollarlist.org) is a compilation of publicly announced charitable donations of $1 million or more from across the United States since 2000; as of December 2016, the database contains close to 80,000 gifts made by U.S. individuals, corporations, foundations, and other grant-making nonprofit organizations. This paper discusses the unique value of the Million Dollar List and provides unique insights to key questions such as: How does distance affect giving? How do networks impact million-dollar-plus gifts? Understanding the geospatial and temporal dimensions of philanthropy can assist researchers and policymakers to better understand the role of private funding in innovation and discovery...
2017: PloS One
https://www.readbyqxmd.com/read/28551658/preoperative-ca-125-values-as-a-predictive-factor-for-the-postoperative-outcome-in-primary-serous-ovarian-cancer
#15
Mustafa Zelal Muallem, Asya Parashkevova, Jumana Almuheimid, Rolf Richter, Yasser Diab, Elena Ioana Braicu, Jalid Sehouli
BACKGROUND/AIM: The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging. PATIENTS AND METHODS: A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28511464/a-study-to-assess-the-functional-outcome-of-decompression-and-posterior-lumbar-interbody-fusion-of-low-grade-spondylolisthesis-of-lumbar-vertebra
#16
Deepak Hegde, Sameer Mehra, Santhosh Babu, Arjun Ballal
INTRODUCTION: Spondylolisthesis is defined as the forward displacement of one vertebra over the vertebra below. It is often accompanied by spinal canal stenosis and compression, which is the cause of all the symptoms. AIM: To assess and study the functional outcome after decompression and Posterior Lumbar Interbody Fusion (PLIF) of isthmic spondylolisthesis of lower lumbar vertebra and to study the complications occurring with this technique. MATERIALS AND METHODS: A prospective study was conducted in the Department of Orthopaedics in Justice KS Hegde Charitable Hospital, Mangalore, Karnataka, India from March 2015 to August 2016...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28497720/neuroscience-and-ethics
#17
S Matthew Liao
A number of people believe that results from neuroscience have the potential to settle seemingly intractable debates concerning the nature, practice, and reliability of moral judgments. In particular, Joshua Greene has argued that evidence from neuroscience can be used to advance the long-standing debate between consequentialism and deontology. This paper first argues that charitably interpreted, Greene's neuroscientific evidence can contribute to substantive ethical discussions by being part of an epistemic debunking argument...
March 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28495106/israel-health-and-beyond
#18
REVIEW
Karl Skorecki, Richard Horton
The principle that global human identity and dignity supersede other values is a broadly accepted conviction that guides practice and policies in the realm of human health in most of the world. An assessment of the level of success that Israel has achieved in health, in the face of formidable challenges, including rapid population growth, diverse and often divided ethnic affiliations, and existential security threats, leads us to propose that extension of this principle of global human identity and dignity, together with the objective of a decent society, as overriding values beyond health to other domains of human endeavour within Israel and in its relations with neighbouring peoples, represents an entirely achievable imperative...
May 5, 2017: Lancet
https://www.readbyqxmd.com/read/28469092/transcriptional-dissection-of-melanoma-identifies-a-high-risk-subtype-underlying-tp53-family-genes-and-epigenome-deregulation
#19
Brateil Badal, Alexander Solovyov, Serena Di Cecilia, Joseph Minhow Chan, Li-Wei Chang, Ramiz Iqbal, Iraz T Aydin, Geena S Rajan, Chen Chen, Franco Abbate, Kshitij S Arora, Antoine Tanne, Stephen B Gruber, Timothy M Johnson, Douglas R Fullen, Leon Raskin, Robert Phelps, Nina Bhardwaj, Emily Bernstein, David T Ting, Georg Brunner, Eric E Schadt, Benjamin D Greenbaum, Julide Tok Celebi
BACKGROUND: Melanoma is a heterogeneous malignancy. We set out to identify the molecular underpinnings of high-risk melanomas, those that are likely to progress rapidly, metastasize, and result in poor outcomes. METHODS: We examined transcriptome changes from benign states to early-, intermediate-, and late-stage tumors using a set of 78 treatment-naive melanocytic tumors consisting of primary melanomas of the skin and benign melanocytic lesions. We utilized a next-generation sequencing platform that enabled a comprehensive analysis of protein-coding and -noncoding RNA transcripts...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28449805/spectrum-of-mismatch-repair-gene-mutations-and-clinical-presentation-of-hispanic-individuals-with-lynch-syndrome
#20
Annette Y Sunga, Charité Ricker, Carin R Espenschied, Danielle Castillo, Marilena Melas, Josef Herzog, Sarah Bannon, Marcia Cruz-Correa, Patrick Lynch, Ilana Solomon, Stephen B Gruber, Jeffrey N Weitzel
Lynch syndrome (LS), the most common hereditary colorectal cancer syndrome, is caused by mismatch repair (MMR) gene mutations. However, data about MMR mutations in Hispanics are limited. This study aims to describe the spectrum of MMR mutations in Hispanics with LS and explore ancestral origins. This case series involved an IRB-approved retrospective chart review of self-identified Hispanic patients (n = 397) seen for genetic cancer risk assessment at four collaborating academic institutions in California, Texas, and Puerto Rico who were evaluated by MMR genotyping and/or tumor analysis...
April 2017: Cancer Genetics
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