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David Nutt

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https://www.readbyqxmd.com/read/27909163/psilocybin-for-anxiety-and-depression-in-cancer-care-lessons-from-the-past-and-prospects-for-the-future
#1
EDITORIAL
David Nutt
No abstract text is available yet for this article.
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27834755/thirty-years-of-journal-of-psychopharmacology
#2
EDITORIAL
David J Nutt
No abstract text is available yet for this article.
November 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27739164/evidence-for-gaba-a-receptor-dysregulation-in-gambling-disorder-correlation-with-impulsivity
#3
Inge Mick, Anna C Ramos, Jim Myers, Paul R Stokes, Samantha Chandrasekera, David Erritzoe, Maria A Mendez, Roger N Gunn, Eugenii A Rabiner, Graham E Searle, José C F Galduróz, Adam D Waldman, Henrietta Bowden-Jones, Luke Clark, David J Nutt, Anne R Lingford-Hughes
As a behavioural addiction, gambling disorder (GD) provides an opportunity to characterize addictive processes without the potentially confounding effects of chronic excessive drug and alcohol exposure. Impulsivity is an established precursor to such addictive behaviours, and GD is associated with greater impulsivity. There is also evidence of GABAergic dysregulation in substance addiction and in impulsivity. This study therefore investigated GABAA receptor availability in 15 individuals with GD and 19 healthy volunteers (HV) using [(11) C]Ro15-4513, a relatively selective α5 benzodiazepine receptor PET tracer and its relationship with impulsivity...
October 13, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27705084/levosimendan-for-the-prevention-of-acute-organ-dysfunction-in-sepsis
#4
Anthony C Gordon, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Robert M L Orme, Shalini Santhakumaran, Alexina J Mason, Mary Cross, Farah Al-Beidh, Janis Best-Lane, David Brealey, Christopher L Nutt, James J McNamee, Henrik Reschreiter, Andrew Breen, Kathleen D Liu, Deborah Ashby
Background Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis. Methods We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis. Patients were randomly assigned to receive a blinded infusion of levosimendan (at a dose of 0.05 to 0.2 μg per kilogram of body weight per minute) for 24 hours or placebo in addition to standard care. The primary outcome was the mean daily Sequential Organ Failure Assessment (SOFA) score in the intensive care unit up to day 28 (scores for each of five systems range from 0 to 4, with higher scores indicating more severe dysfunction; maximum score, 20)...
October 5, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27703042/the-iccam-platform-study-an-experimental-medicine-platform-for-evaluating-new-drugs-for-relapse-prevention-in-addiction-part-b-fmri-description
#5
John McGonigle, Anna Murphy, Louise M Paterson, Laurence J Reed, Liam Nestor, Jonathan Nash, Rebecca Elliott, Karen D Ersche, Remy Sa Flechais, Rexford Newbould, Csaba Orban, Dana G Smith, Eleanor M Taylor, Adam D Waldman, Trevor W Robbins, Jf William Deakin, David J Nutt, Anne R Lingford-Hughes, John Suckling
OBJECTIVES: We aimed to set up a robust multi-centre clinical fMRI and neuropsychological platform to investigate the neuropharmacology of brain processes relevant to addiction - reward, impulsivity and emotional reactivity. Here we provide an overview of the fMRI battery, carried out across three centres, characterizing neuronal response to the tasks, along with exploring inter-centre differences in healthy participants. EXPERIMENTAL DESIGN: Three fMRI tasks were used: monetary incentive delay to probe reward sensitivity, go/no-go to probe impulsivity and an evocative images task to probe emotional reactivity...
October 4, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27688219/strengthening-health-systems-while-responding-to-a-health-crisis-lessons-learned-by-a-nongovernmental-organization-during-the-ebola-virus-disease-epidemic-in-sierra-leone
#6
Corrado Cancedda, Sheila M Davis, Kerry L Dierberg, Jonathan Lascher, J Daniel Kelly, Mohammed Bailor Barrie, Alimamy Philip Koroma, Peter George, Adikali Alpha Kamara, Ronald Marsh, Manso S Sumbuya, Cameron T Nutt, Kirstin W Scott, Edgar Thomas, Katherine Bollbach, Andrew Sesay, Ahmidu Barrie, Elizabeth Barrera, Kathryn Barron, John Welch, Nahid Bhadelia, Raphael G Frankfurter, Ophelia M Dahl, Sarthak Das, Rebecca E Rollins, Bryan Eustis, Amanda Schwartz, Piero Pertile, Ilias Pavlopoulos, Allan Mayfield, Regan H Marsh, Yusupha Dibba, Danielle Kloepper, Andrew Hall, Karin Huster, Michael Grady, Kimberly Spray, David A Walton, Fodei Daboh, Cora Nally, Sahr James, Gabriel S Warren, Joyce Chang, Michael Drasher, Gina Lamin, Sherry Bangura, Ann C Miller, Annie P Michaelis, Ryan McBain, M Jana Broadhurst, Megan Murray, Eugene T Richardson, Ted Philip, Gary L Gottlieb, Joia S Mukherjee, Paul E Farmer
An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27650729/neurochemical-binding-profiles-of-novel-indole-and-benzofuran-mdma-analogues
#7
Jakob A Shimshoni, Ilan Winkler, Ezekiel Golan, David Nutt
3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues (1-(benzofuran-5-yl)-propan-2-amine, 5-APB; 1-(benzofuran-6-yl)-N-methylpropan-2-amine, 6-MAPB; 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 5-MAPB) and one MDMA-indole analogue (1-(1H-indol-5-yl)-2-methylamino-propan-1-ol, 5-IT). These compounds were screened as potential second-generation anti-PTSD drugs, against a battery of human and non-human receptors, transporters, and enzymes, and their potencies as 5-HT2 receptor agonist and monoamine uptake inhibitors determined...
September 20, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27600363/acute-naltrexone-does-not-remediate-fronto-striatal-disturbances-in-alcoholic-and-alcoholic-polysubstance-dependent-populations-during-a-monetary-incentive-delay-task
#8
Liam J Nestor, Anna Murphy, John McGonigle, Csaba Orban, Laurence Reed, Eleanor Taylor, Remy Flechais, Louise M Paterson, Dana Smith, Edward T Bullmore, Karen D Ersche, John Suckling, Roger Tait, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne Lingford-Hughes, David J Nutt, Barbara Sahakian, Trevor W Robbins
There is a concerted research effort to investigate brain mechanisms underlying addiction processes that may predicate the development of new compounds for treating addiction. One target is the brain's opioid system, because of its role in the reinforcing effects of substances of abuse. Substance-dependent populations have increased numbers of the mu opioid receptor (MOR) in fronto-striatal regions that predict drug relapse, and demonstrate disturbances in these regions during the processing of non-drug rewards...
September 6, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27585792/acute-and-chronic-effects-of-cannabinoids-on-effort-related-decision-making-and-reward-learning-an-evaluation-of-the-cannabis-amotivational-hypotheses
#9
Will Lawn, Tom P Freeman, Rebecca A Pope, Alyssa Joye, Lisa Harvey, Chandni Hindocha, Claire Mokrysz, Abigail Moss, Matthew B Wall, Michael Ap Bloomfield, Ravi K Das, Celia Ja Morgan, David J Nutt, H Valerie Curran
RATIONALE: Anecdotally, both acute and chronic cannabis use have been associated with apathy, amotivation, and other reward processing deficits. To date, empirical support for these effects is limited, and no previous studies have assessed both acute effects of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as associations with cannabis dependence. OBJECTIVES: The objectives of this study were (1) to examine acute effects of cannabis with CBD (Cann + CBD) and without CBD (Cann-CBD) on effort-related decision-making and (2) to examine associations between cannabis dependence, effort-related decision-making and reward learning...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27581977/packaging-and-prefusion-stabilization-separately-and-additively-increase-the-quantity-and-quality-of-respiratory-syncytial-virus-rsv-neutralizing-antibodies-induced-by-an-rsv-fusion-protein-expressed-by-a-parainfluenza-virus-vector
#10
Bo Liang, Joan O Ngwuta, Richard Herbert, Joanna Swerczek, David W Dorward, Emerito Amaro-Carambot, Natalie Mackow, Barbora Kabatova, Matthias Lingemann, Sonja Surman, Lijuan Yang, Man Chen, Syed M Moin, Azad Kumar, Jason S McLellan, Peter D Kwong, Barney S Graham, Anne Schaap-Nutt, Peter L Collins, Shirin Munir
: Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major pediatric respiratory pathogens that lack vaccines. A chimeric bovine/human PIV3 (rB/HPIV3) virus expressing the unmodified, wild-type (wt) RSV fusion (F) protein from an added gene was previously evaluated in seronegative children as a bivalent intranasal RSV/HPIV3 vaccine, and it was well tolerated but insufficiently immunogenic for RSV F. We recently showed that rB/HPIV3 expressing a partially stabilized prefusion form (pre-F) of RSV F efficiently induced "high-quality" RSV-neutralizing antibodies, defined as antibodies that neutralize RSV in vitro without added complement (B...
November 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27524439/proximity-based-differential-single-cell-analysis-of-the-niche-to-identify-stem-progenitor-cell-regulators
#11
Lev Silberstein, Kevin A Goncalves, Peter V Kharchenko, Raphael Turcotte, Youmna Kfoury, Francois Mercier, Ninib Baryawno, Nicolas Severe, Jacqueline Bachand, Joel A Spencer, Ani Papazian, Dongjun Lee, Brahmananda Reddy Chitteti, Edward F Srour, Jonathan Hoggatt, Tiffany Tate, Cristina Lo Celso, Noriaki Ono, Stephen Nutt, Jyrki Heino, Kalle Sipilä, Toshihiro Shioda, Masatake Osawa, Charles P Lin, Guo-Fu Hu, David T Scadden
Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of mesenchymal osteolineage cells close to, and further removed from, hematopoietic stem/progenitor cells (HSPCs) to identify candidate niche factors. Mesenchymal cells displayed distinct molecular profiles based on their relative location. We functionally examined, among the genes that were preferentially expressed in proximal cells, three secreted or cell-surface molecules not previously connected to HSPC biology-the secreted RNase angiogenin, the cytokine IL18, and the adhesion molecule Embigin-and discovered that all of these factors are HSPC quiescence regulators...
October 6, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27461515/whole-genome-expression-analysis-reveals-genes-associated-with-treatment-response-to-escitalopram-in-major-depression
#12
Kristi Pettai, Lili Milani, Anu Tammiste, Urmo Võsa, Raivo Kolde, Triin Eller, David Nutt, Andres Metspalu, Eduard Maron
The reasons for variability in treatment response in major depressive disorder (MDD) are not fully understood, but there is accumulating evidence suggesting that therapeutic outcomes of antidepressants can be influenced by genetic factors. In the present study we applied the microarray Illumina platform for whole genome expression profiling in depressive patients treated with escitalopram medication in order to identify genes underlying response to antidepressant treatment. The initial study sample consisted of 135 outpatients with major depressive disorder (mean age 31...
September 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27419272/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-ii-neurochemistry-neurophysiology-and-neurocognition
#13
Borwin Bandelow, David Baldwin, Marianna Abelli, Blanca Bolea-Alamanac, Michel Bourin, Samuel R Chamberlain, Eduardo Cinosi, Simon Davies, Katharina Domschke, Naomi Fineberg, Edna Grünblatt, Marek Jarema, Yong-Ku Kim, Eduard Maron, Vasileios Masdrakis, Olya Mikova, David Nutt, Stefano Pallanti, Stefano Pini, Andreas Ströhle, Florence Thibaut, Matilde M Vaghi, Eunsoo Won, Dirk Wedekind, Adam Wichniak, Jade Woolley, Peter Zwanzger, Peter Riederer
OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
July 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27403679/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-i-neuroimaging-and-genetics
#14
Borwin Bandelow, David Baldwin, Marianna Abelli, Carlo Altamura, Bernardo Dell'Osso, Katharina Domschke, Naomi A Fineberg, Edna Grünblatt, Marek Jarema, Eduard Maron, David Nutt, Stefano Pini, Matilde M Vaghi, Adam Wichniak, Gwyneth Zai, Peter Riederer
OBJECTIVES: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
August 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27388945/balancing-stealth-and-echogenic-properties-in-an-ultrasound-contrast-agent-with-drug-delivery-potential
#15
Lauren J Jablonowski, David Alfego, James I Andorko, John R Eisenbrey, Nutte Teraphongphom, Margaret A Wheatley
Contrast agents are currently being modified to combine diagnostic and therapeutic capabilities. For ultrasound (US) imaging with polymeric contrast agents, it is necessary to modify the shell to create "stealth" microbubbles but without these modifications sacrificing the agent's ability to interact with the focused US beam. We hypothesize that addition of the classic immune shielding molecule polyethylene glycol (PEG) to a polylactide (PLA) microbubble shell will affect the acoustic and physical properties of the resulting agents...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27378878/ego-dissolution-and-psychedelics-validation-of-the-ego-dissolution-inventory-edi
#16
Matthew M Nour, Lisa Evans, David Nutt, Robin L Carhart-Harris
AIMS: The experience of a compromised sense of "self", termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. METHOD: Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27338804/behavioural-tasks-sensitive-to-acute-abstinence-and-predictive-of-smoking-cessation-success-a-systematic-review-and-meta-analysis
#17
Meryem Grabski, H Valerie Curran, David J Nutt, Stephen M Husbands, Tom P Freeman, Meg Fluharty, Marcus R Munafò
BACKGROUND AND AIMS: Performance on cognitive tasks may be sensitive to acu;te smoking abstinence and may also predict whether quit attempts fail. Our aim was to conduct a systematic review and meta-analysis to identify cognitive tasks sensitive to acute abstinence and predictive of smoking cessation success. METHODS: Embase, Medline, PsycInfo and Web of Science were searched up to March 2016. Studies were included if they enrolled adults and assessed smoking using a quantitative measure...
June 24, 2016: Addiction
https://www.readbyqxmd.com/read/27329165/don-t-panic-a-guide-to-tryptophan-depletion-with-disorder-specific-anxiety-provocation
#18
S D Hood, C J Bell, S V Argyropoulos, D J Nutt
The 2002 paper "Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine" by Bell and colleagues - reprinted in this issue of the Journal - reports on a study undertaken in the halcyon days of David Nutt's Psychopharmacology Unit at the University of Bristol, England. In this invited commentary authors of the original work discuss the impact of this paper on the field of acute tryptophan depletion research (especially in the field of clinical anxiety disorders) and the development of disorder-specific anxiogenic provocations over the past decade...
June 20, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27307288/reduced-heart-rate-variability-in-remitted-bipolar-disorder-and-recurrent-depression
#19
Darryl Bassett, Natasha Bear, David Nutt, Sean Hood, Sherylee Bassett, Davinder Hans
OBJECTIVE: There is evidence that mood disorders are associated with impaired parasympathetic nervous system function and consequently increased morbidity and mortality. Our study addresses whether this impairment persists into remission in unipolar and bipolar disorders. METHODS: Heart Rate Variability was measured in groups of subjects during remission, with Bipolar Affective Disorder I (n = 29), recurrent Major Depressive Disorder (n = 41) and a healthy control group (n = 38), during the bedtime period...
August 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27273695/significant-reductions-in-human-visual-gamma-frequency-by-the-gaba-reuptake-inhibitor-tiagabine-revealed-by-robust-peak-frequency-estimation
#20
Lorenzo Magazzini, Suresh D Muthukumaraswamy, Anne E Campbell, Khalid Hamandi, Anne Lingford-Hughes, Jim F M Myers, David J Nutt, Petroc Sumner, Sue J Wilson, Krish D Singh
The frequency of visual gamma oscillations is determined by both the neuronal excitation-inhibition balance and the time constants of GABAergic processes. The gamma peak frequency has been linked to sensory processing, cognitive function, cortical structure, and may have a genetic contribution. To disentangle the intricate relationship among these factors, accurate and reliable estimates of peak frequency are required. Here, a bootstrapping approach that provides estimates of peak frequency reliability, thereby increasing the robustness of the inferences made on this parameter was developed...
June 7, 2016: Human Brain Mapping
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