Ana Benzaquén, Estela Giménez, Gloria Iacoboni, Manuel Guerreiro, Rafael Hernani, Eliseo Albert, Cecilia Carpio, Aitana Balaguer, Ariadna Pérez, Carlos S de la Asunción, Mario Andrés Sánchez-Salinas, Pedro Chorão, José Luis Piñana, Francisco Beas, Juan Montoro, Juan Carlos Hernández-Boluda, Ana Facal, Blanca Ferrer, Marta Villalba, Paula Amat, María Dolores Goméz, Diana Campos, María José Terol, Jaime Sanz, Pere Barba, David Navarro, Carlos Solano
Torque Teno Virus (TTV) is a single-stranded circular DNA virus which has been identified as a surrogate marker of immune competence in transplantation. In this study we investigated the dynamics of plasma TTV DNAemia in 79 adult patients undergoing chimeric antigen receptor T-cell (CAR-T) therapy for relapsed or refractory large B-cell lymphoma, also evaluating the impact of TTV on immunotoxicities, response and survival outcomes. After lymphodepleting therapy, TTV DNA load was found to decrease slightly until reaching nadir around day 10, after which it increased steadily until reaching maximum load around day 90...
January 2024: Bone Marrow Transplantation