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Torque Teno

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https://www.readbyqxmd.com/read/29727487/kinetics-of-torque-teno-virus-dna-load-in-saliva-and-plasma-following-allogeneic-hematopoietic-stem-cell-transplantation
#1
Eliseo Albert, Ignacio Torres, Alberto Talaya, Estela Giménez, José Luis Piñana, Juan Carlos Hernández-Boluda, Daniele Focosi, Lisa Macera, Fabrizio Maggi, Carlos Solano, David Navarro
Plasma Torque Teno virus (TTV) DNA load directly correlates with the degree of T-cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution following engraftment. This prospective observational study enrolled 38 non-consecutive allo-HSCT recipients. Saliva and plasma specimens were collected at baseline (pre-transplant) and at around days +30, +50 and +90 after allo-HSCT...
May 4, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29644247/quantification-of-torque-teno-virus-and-epstein-barr-virus-is-of-limited-value-for-predicting-the-net-state-of-immunosuppression-after-lung-transplantation
#2
Rickard Nordén, Jesper Magnusson, Anna Lundin, Ka-Wei Tang, Staffan Nilsson, Magnus Lindh, Lars-Magnus Andersson, Gerdt C Riise, Johan Westin
Background: Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. Methods: This prospective single-center study included 98 patients followed for 2 years after transplantation...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29625161/development-of-a-taqman-based-real-time-pcr-assay-for-the-rapid-and-specific-detection-of-pigeon-torque-teno-virus
#3
Wan Chunhe, Chen Cuiteng, Cheng Longfei, Fu Guanghua, Shi Shaohua, Fu Qiuling, Liu Rongchang, Chen Hongmei, Huang Yu
Pigeon torque teno virus (PTTV), a recently discovered circular DNA virus. Here, we developed a TaqMan-based real-time PCR for rapid and specific detection of PTTV infections with sensitivity up to 49.3 copies/μl. Positive signals can be observed by the assay in pigeon embryonated eggs, which indicted that PTTV can be transmitted vertically. Our findings play important implications for a better understanding the transmission of torque teno virus in pigeons.
April 3, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29587272/development-of-an-immunoassay-for-detection-of-torque-teno-virus-ttv-antibodies-using-the-n22-expression-product-from-ttv-genotype-2
#4
Dhananjay Singh Mankotia, Mohammad Irshad
AIMS: This study describes an immunoassay to detect anti-torque teno virus (TTV) antibodies using a peptide obtained from expression of the N22 region of TTV genotype 2. METHODS: The N22 region (∼500 bp) of TTV genotype 2 was cloned in a pET-28a(+) vector and expressed in ZYM-5052 autoinduction medium. Following metal affinity chromatography, a purified polypeptide was used as an antigen for the development of an immunoassay to detect anti-TTV antibodies in human sera...
March 27, 2018: Intervirology
https://www.readbyqxmd.com/read/29568043/first-detection-of-human-hepegivirus-1-hhpgv-1-in-iranian-patients-with-hemophilia
#5
Yazdan Bijvand, Mohammad Reza Aghasadeghi, Fatemeh Sakhaee, Parviz Pakzad, Farzam Vaziri, Alireza Azizi Saraji, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Abolfazl Fateh
A novel blood-borne virus called the human hepegivirus 1 (HHpgV-1) was recently discovered in hemophilia patients. The present study aimed to investigate the presence of HHpgV-1 in hemophilia patients. A total of 436 serum samples were investigated for the presence of hepatitis C virus (HCV), human pegivirus-1 (HPgV-1), torque teno virus (TTV), and HHpgV-1. Out of the 436 patients, 163 (37.4%), 19 (4.4%), 76 (17.4%), and four (0.9%) patients were positive for HCV, HPgV-1, TTV, and HHpgV-1, respectively. HHpgV-1 patients had a mean viral load of 4...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29551863/detection-of-cytomegalovirus-epstein-barr-virus-and-torque-teno-virus-in-subgingival-and-atheromatous-plaques-of-cardiac-patients-with-chronic-periodontitis
#6
Sriraman Priyanka, Gurumoorthy Kaarthikeyan, Jayakumar Doraiswamy Nadathur, Anbarasu Mohanraj, Avinash Kavarthapu
Background: Periodontitis and atherosclerosis represent a chronic inflammatory process. The incidence of periodontitis in cardiac patients with atherosclerosis is a well-established fact. The role of viruses in the etiopathogenesis of both has been proposed. Aim: The aim of the study was to evaluate the prevalence of Torque Teno virus (TTV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in cardiac patients with atherosclerosis and coexisting chronic periodontitis (CP)...
November 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29548656/clinical-significance-of-changes-in-torque-teno-virus-dna-titer-after-chemotherapy-in-patients-with-primary-lung-cancer
#7
Tetsuro Sawata, Masashi Bando, Masayuki Nakayama, Naoko Mato, Hideaki Yamasawa, Masaharu Takahashi, Hiroaki Okamoto, Yukihiko Sugiyama
BACKGROUND: Several studies have reported that viral infections are related to lung cancer. We previously reported the involvement of Torque teno virus (TTV) in patients with lung cancer and idiopathic pulmonary fibrosis. However, the role of TTV in lung cancer growth, and its influence on changes in TTV DNA titers due to idiopathic pulmonary fibrosis (IPF) in lung cancer patients are poorly understood. METHODS: Serum TTV DNA titers were measured in serum samples obtained from patients with lung cancer...
March 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29426408/potential-for-the-cross-species-transmission-of-swine-torque-teno-viruses
#8
Gagandeep Singh, Sheela Ramamoorthy
Torque teno viruses [TTVs] are negative sense, single-stranded, DNA viruses, which are distributed globally in several mammalian hosts such as humans, apes, sheep and swine in a species-specific manner. While the pathogenic potential of TTVs is under debate, recent experimental studies in gnotobiotic pigs indicate that swine TTVs, TTSuV1 in particular, can act as a primary or co-infecting pathogen. Hence, determining whether TTSuV1 can infect other mammals would eventually further our understanding of viral pathogenesis, especially in coinfections...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29407376/detection-and-phylogenetic-analysis-of-torque-teno-virus-ttv-carried-by-murine-rodents-and-house-shrews-in-china
#9
Yi-Quan Xiong, Yun Mo, Ming-Ji Chen, Wei Cai, Wen-Qiao He, Qing Chen
Between May 2015 and May 2017, 496 animals (473 murine rodents and 23 house shrews) were captured in six regions of China. A total of 22.8% (113/496) of throat swabs, 29.1% (142/488) of fecal samples and 23.8% (54/227) of serum samples tested positive for rodent torque teno virus 3 (RoTTV3). The positive rate in Rattus norvegicus was higher than the rate in Rattus tanezumi and Rattus losea. Of 23 house shrews, one throat swab and one serum sample were positive for RoTTV3. Ten murine rodents were simultaneously positive for RoTTV3 in throat swab, fecal and serum samples...
March 2018: Virology
https://www.readbyqxmd.com/read/29311716/discovering-viral-genomes-in-human-metagenomic-data-by-predicting-unknown-protein-families
#10
Mauricio Barrientos-Somarribas, David N Messina, Christian Pou, Fredrik Lysholm, Annelie Bjerkner, Tobias Allander, Björn Andersson, Erik L L Sonnhammer
Massive amounts of metagenomics data are currently being produced, and in all such projects a sizeable fraction of the resulting data shows no or little homology to known sequences. It is likely that this fraction contains novel viruses, but identification is challenging since they frequently lack homology to known viruses. To overcome this problem, we developed a strategy to detect ORFan protein families in shotgun metagenomics data, using similarity-based clustering and a set of filters to extract bona fide protein families...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29285888/presence-of-torque-teno-sus-virus-1-and-2-in-porcine-circovirus-3-positive-pigs
#11
S Zheng, J Shi, X Wu, Z Peng, C Xin, L Zhang, Y Liu, M Gao, S Xu, H Han, J Yu, W Sun, X Cong, J Li, J Wang
In this study, the co-infection of Torque teno sus virus (TTSuV) and porcine circovirus type 3 (PCV3) was reported. One hundred and ten of 132 (83.3%) PCV3-positive samples were co-infected with Torque teno sus virus 1 (TTSuV1). Ninety-four of 132 (71.2%) PCV3-positive samples were co-infected with Torque teno sus virus 2 (TTSuV2). Sixty-six of 132 (50.0%) of PCV3-positive samples were co-infected with both TTSuV1 and TTSuV2. There were no clinical signs of infection in pigs that were both PCV3-positive and PCV2-negative, in either multiparous sows or live-born infants...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29285293/two-new-species-of-betatorqueviruses-identified-in-a-human-melanoma-that-metastasized-to-the-brain
#12
Terry Fei Fan Ng, Jennifer A Dill, Alvin C Camus, Eric Delwart, Erwin G Van Meir
The role of viral infections in the etiology of brain cancer remains uncertain. Prior studies mostly focused on transcriptome or viral DNA integrated in tumor cells. To investigate for the presence of viral particles, we performed metagenomics sequencing on viral capsid-protected nucleic acids from 12 primary and 8 metastatic human brain tumors. One brain tumor metastasized from a skin melanoma harbored two new human anellovirus species, Torque teno mini virus Emory1 (TTMV Emory1) and Emory2 (TTMV Emory2), while the remaining 19 samples did not reveal any exogenous viral sequences...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29251582/association-between-cytotoxic-t-lymphocyte-antigen-4-gene-polymorphisms-and-torque-teno-virus-infection-after-hematopoietic-stem-cell-transplantation
#13
Mani Ramzi, Mahdiyar Iravani Saadi, Tahereh Zarei, Ramin Yaghobi, Nargess Arandi
OBJECTIVES: An association between costimulatory molecule gene polymorphisms and viral infection after hematopoietic stem cell transplantation may be related to clinical outcomes, especially acute graft-versus-host disease. Cytotoxic T-lymphocyte antigen 4 has been suggested as a crucial negative regulator of the immune system. In this study, our objective was to investigate the association between cytotoxic T-lymphocyte antigen-4 gene polymorphisms (including -1722 T/C, -1661 A/G, -318 C/T, and +49 A/G) and torque teno virus infection after hematopoietic stem cell transplantation in patients with and without acute graft-versus-host disease...
December 18, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29189638/viral-dnaemia-and-immune-suppression-in-pediatric-sepsis
#14
Sam Davila, E Scott Halstead, Mark W Hall, Allan Doctor, Russell Telford, Richard Holubkov, Joseph A Carcillo, Gregory A Storch
OBJECTIVES: Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN: Retrospective analysis of a prospective cohort study. PATIENTS: Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: This study was performed as an ancillary investigation to a single-center prospective study of children with severe sepsis...
January 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29143186/identification-of-an-anellovirus-and-genomoviruses-in-ixodid-ticks
#15
Kara Waits, Marten J Edwards, Ilaria N Cobb, Rafaela S Fontenele, Arvind Varsani
Ticks are blood-feeding arachnids that are vectors of several important human and animal pathogens. Little is known about single-stranded DNA (ssDNA) viruses that are associated with these ectoparasites. As part of a pilot study to identify ssDNA viruses present in ticks, female American dog ticks (Dermacentor variabilis) and blacklegged ticks (Ixodes scapularis) were collected in eastern Pennsylvania (USA), and the extracted viral DNA was analyzed using viral metagenomics approaches. Three genomoviruses were recovered from pooled samples of D...
February 2018: Virus Genes
https://www.readbyqxmd.com/read/29103646/comparative-enteric-viruses-and-coliphage-removal-during-wastewater-treatment-processes-in-a-sub-tropical-environment
#16
J P S Sidhu, K Sena, L Hodgers, A Palmer, S Toze
Microbiological safety of reclaimed water is one of the most important issues in managing potential health risks related to wastewater recycling. Presence and removal of human adenovirus (HAdV), human polyomavirus (HPyV), human torque teno virus (HTtV) and somatic coliphage family Microviridae in three wastewater treatment plants (WWTP) in sub-tropical Brisbane, Australia was investigated. All three WWTPs employ activated sludge process with added on Bardenpho process for nutrient removal. HPyV, HAdV, HTtV and Microviridae were consistently detected in the influent (105 to 106 Genomic copies (GC) L-1 ) and secondary treated effluent (102 to 103 GCL- 1 )...
March 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29084205/the-kinetics-of-torque-teno-virus-plasma-dna-load-shortly-after-engraftment-predicts-the-risk-of-high-level-cmv-dnaemia-in-allogeneic-hematopoietic-stem-cell-transplant-recipients
#17
E Albert, C Solano, E Giménez, D Focosi, A Pérez, L Macera, J L Piñana, J C H Boluda, F Maggi, D Navarro
Monitoring Torque teno virus (TTV) DNA load helps to estimate the risk of opportunistic infections in solid organ transplant recipients. We investigated whether the early kinetic pattern of plasma TTV DNA load after allogeneic hematopoietic stem cell transplantation (allo-HSCT) associates with subsequent CMV and EBV DNAemia. This study included 71 allo-HSCT patients. We found that the area under the curve (AUC) for log10 TTV DNA loads quantified by days 20 and 30 after transplantation (TTV DNA load AUC20-30 ), was significantly lower (P=0...
February 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29083040/metagenomic-analysis-of-viral-diversity-in-respiratory-samples-from-patients-with-respiratory-tract-infections-in-kuwait
#18
Nada Madi, Widad Al-Nakib, Abu Salim Mustafa, Nazima Habibi
A metagenomic approach based on target independent next-generation sequencing has become a known method for the detection of both known and novel viruses in clinical samples. This study aimed to use the metagenomic sequencing approach to characterize the viral diversity in respiratory samples from patients with respiratory tract infections. We have investigated 86 respiratory samples received from various hospitals in Kuwait between 2015 and 2016 for the diagnosis of respiratory tract infections. A metagenomic approach using the next-generation sequencer to characterize viruses was used...
March 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/28992518/comprehensive-detection-of-viruses-in-pediatric-patients-with-acute-liver-failure-using-next-generation-sequencing
#19
Takako Suzuki, Jun-Ichi Kawada, Yusuke Okuno, Satoshi Hayano, Kazuhiro Horiba, Yuka Torii, Yoshiyuki Takahashi, Syuichiro Umetsu, Tsuyoshi Sogo, Ayano Inui, Yoshinori Ito
BACKGROUND: Pediatric acute liver failure (PALF) is a rare and severe syndrome that frequently requires liver transplantation. Viruses are one of the most frequent causes of this disease, however, pathogenic viruses are not determined in many patients. Recently next-generation sequencing (NGS) has been applied to comprehensively detect pathogens of infectious diseases of unknown etiology. OBJECTIVES: To evaluate an NGS-based approach for detecting pathogenic viruses in patients with PALF or acute hepatitis of unknown etiology...
November 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28972950/phylogenetic-analysis-of-torque-teno-virus-in-thalassemic-children-in-egypt
#20
Noha A Hassuna, Eman Naguib, Medhat Abdel-Fatah, Suzan M Omar Mousa
OBJECTIVE: Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS: TTV was detected in 2 groups by nested PCR: the first group comprised 200 children with thalassemia, and the second included age- and sex-matched healthy children with no history of blood transfusion...
2017: Intervirology
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