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Early repolarization

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https://www.readbyqxmd.com/read/29141592/case-report-electrical-storm-during-induced-hypothermia-in-a-patient-with-early-repolarization
#1
Patrick Badertscher, Michael Kuehne, Beat Schaer, Christian Sticherling, Stefan Osswald, Tobias Reichlin
BACKGROUND: Population based studies showed an association of early repolarization in the electrocardiogram (ECG) and a higher rate of sudden cardiac death presumably due to ventricular fibrillation. The triggers for ventricular fibrillation in patients with early repolarization are not fully understood. CASE PRESENTATION: We describe the case of a young patient with a survived ventricular fibrillation arrest while asleep followed by multiple episodes of recurrent ventricular fibrillation...
November 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29130071/the-electrophysiological-substrate-of-early-repolarization-syndrome-noninvasive-mapping-in-patients
#2
Junjie Zhang, Mélèze Hocini, Maria Strom, Phillip S Cuculich, Daniel H Cooper, Frédéric Sacher, Michel Haïssaguerre, Yoram Rudy
Background: The early repolarization (ER) pattern is a common ECG finding. Recent studies established a definitive clinical association between ER and fatal ventricular arrhythmias. However, the arrhythmogenic substrate of ER in the intact human heart has not been characterized. Objectives: To map the epicardial electrophysiological (EP) substrate in ER syndrome patients using noninvasive Electrocardiographic Imaging (ECGI), and to characterize substrate properties that support arrhythmogenicity...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29127703/comparison-of-two-highly-automated-ecg-algorithms-for-detection-of-drug-induced-cardiac-ion-channel-block
#3
M Brockway, A A Fossa, J W Mason
FDA investigators recently demonstrated in a crossover study that early (J-Tpeak c) and late (Tpeak -Tend ) repolarization duration can differentiate selective potassium block with a high arrhythmia risk from multichannel block with lower risk in subjects receiving dofetilide, verapamil, quinidine or ranolazine. The purpose of this study was to determine if findings by FDA using their published software algorithm could be corroborated using an alternative software algorithm for the same metrics and to determine if methodological differences resulted in clinically meaningful differences in interpretation...
November 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29127493/late-sodium-current-associated-cardiac-electrophysiological-and-mechanical-dysfunction
#4
REVIEW
Shandong Yu, Gang Li, Christopher L-H Huang, Ming Lei, Lin Wu
Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacological cardiovascular conditions, including bradycardia, myocardial ischemia, reperfusion injury, and heart failure...
November 10, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29080970/ibrutinib-does-not-prolong-the-corrected-qt-interval-in-healthy-subjects-results-from-a-thorough-qt-study
#5
Jan de Jong, Peter Hellemans, James Juhui Jiao, Yuhan Huang, Sofie Mesens, Juthamas Sukbuntherng, Daniele Ouellet
PURPOSE: Ibrutinib is an orally administered, irreversible Bruton's tyrosine kinase inhibitor for treatment of B-cell malignancy. This study evaluated the effects of single-dose ibrutinib at therapeutic and supratherapeutic exposures on cardiac repolarization in healthy subjects. METHODS: Part 1 used an open-label, two-period sequential design to assess the safety and pharmacokinetics of single doses of ibrutinib 840 and 1680 mg in eight subjects. Part 2 was a randomized, placebo- and positive (moxifloxacin)-controlled, double-blind, single dose, four-way cross-over study to assess the effect of ibrutinib (840 and 1680 mg) on QT/QTc interval...
October 28, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29067908/evaluation-of-baseline-ecg-in-patients-undergoing-oral-flecainide-challenge-test-for-suspected-brugada-syndrome-an-analysis-of-lead-ii
#6
Maneesh K Rai, Mukund A Prabhu, Jayaprakash Shenthar, Natarajan Kumaraswamy U, Ritesh Vekariya, Padmanabh Kamath, Narasimha Pai, Ramanath L Kamath, Vivek Pillai
BACKGROUND AND OBJECTIVES: We analyzed Lead II in patients undergoing an Oral Flecainide Challenge test (FCT), to identify any pointers that could predict a positive FCT and thereby help in recognition of latent BS. METHODS: The following parameters in lead II were retrospectively analyzed from the pre-test ECG in 62 patients undergoing FCT for suspected BS: The presence or absence of S waves, S wave amplitude, duration and upslope duration; J point parameters- Early repolarization, QRS notch, and QRS Slur; ST segment parameters-lack of isoelectric ST segment, ST duration and QT interval...
July 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29050732/-epidemiology-of-early-repolarization-pattern-in-maghreb
#7
W Amara, S A Bouallouche, A Rezoug, A El Hraiech, A Iusuf, N Hammoudi
An early repolarization variant (ERV) in inferolateral leads has recently been associated with vulnerability to ventricular fibrillation. These studies have been conducted in the occidental countries. The prevalence of ERV in the population of the Maghreb is unknown. The aim of this study was to evaluate the prevalence and risk factors of ERV in a young population from Algeria. METHODS: We assessed the prevalence of ERV within a population of 441 healthy subjects (mean age 25 years) using 12-lead electrocardiography...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29045640/action-potential-contour-contributes-to-species-differences-in-repolarization-response-to-%C3%AE-adrenergic-stimulation
#8
Luca Sala, Bence Hegyi, Chiara Bartolucci, Claudia Altomare, Marcella Rocchetti, Krisztina Váczi, Gaspare Mostacciuolo, Norbert Szentandrássy, Stefano Severi, Péter Pál Nánási, Antonio Zaza
Aim: Repolarization response to β-adrenergic (β-AR) stimulation differs between guinea-pig and canine myocytes and, within the latter, between myocardial layers. Correlative analysis suggests that this may be due to differences in action potential (AP) contour. Here we tested whether AP contour may set the response of current and of repolarization to β-AR stimulation (10 nM isoproterenol, ISO). Methods and Results: The responses of AP and current to ISO were measured under I-clamp and "AP-clamp" in guinea-pig (GP), dog epicardial (DEPI) and dog subendocardial (DENDO) myocytes...
October 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29038312/dynamic-stroma-reorganization-drives-blood-vessel-dysmorphia-during-glioma-growth
#9
Thomas Mathivet, Claire Bouleti, Matthias Van Woensel, Fabio Stanchi, Tina Verschuere, Li-Kun Phng, Joost Dejaegher, Marly Balcer, Ken Matsumoto, Petya B Georgieva, Jochen Belmans, Raf Sciot, Christian Stockmann, Massimiliano Mazzone, Steven De Vleeschouwer, Holger Gerhardt
Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tumor progression are poorly understood. Using longitudinal intravital imaging in a mouse glioma model, we identify that dynamic sprouting and functional morphogenesis of a highly branched vessel network characterize the initial tumor growth, dramatically changing to vessel expansion, leakage, and loss of branching complexity in the later stages...
October 16, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29033520/author-reply-to-letter-to-the-editor-silent-and-malignant-early-repolarization-syndrome-mimicking-hyper-acute-st-elevation-myocardial-infarction
#10
Weng-Chio Tam, Ming-Hsiung Hsieh, Yung-Kuo Lin, Jong-Shiuan Yeh
No abstract text is available yet for this article.
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033519/end-qrs-notching-and-slurring-in-the-definition-of-early-repolarization
#11
Mehmet Eyuboglu, Yalcın Ozkurt
No abstract text is available yet for this article.
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29021844/intracoronary-acetylcholine-application-as-a-possible-probe-inducing-j-waves-in-patients-with-early-repolarization-syndrome
#12
REVIEW
Toru Maruyama, Kazumasa Fujita, Kei Irie, Shouhei Moriyama, Mitsuhiro Fukata
Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS complex in a surface electrocardiogram. The J wave is attributed to the transmural voltage gradient at the early repolarization phase across the ventricular wall, which stems mainly from prominent transient outward current in the epicardium, but not in the endocardium...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29016852/potassium-channel-dysfunction-underlies-purkinje-neuron-spiking-abnormalities-in-spinocerebellar-ataxia-type-2
#13
James M Dell'Orco, Stefan M Pulst, Vikram G Shakkottai
Alterations in Purkinje neuron firing often accompany ataxia, but the molecular basis for these changes is poorly understood. In a mouse model of spinocerebellar ataxia type 2 (SCA2), a progressive reduction in Purkinje neuron firing frequency accompanies cell atrophy. We investigated the basis for altered Purkinje neuron firing in SCA2. A reduction in the expression of large-conductance calcium-activated potassium (BK) channels and Kv3.3 voltage-gated potassium channels accompanies the inability of Purkinje neurons early in disease to maintain repetitive spiking...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29016724/triggered-intracellular-calcium-waves-in-dog-and-human-left-atrial-myocytes-from-normal-and-failing-hearts
#14
Gary L Aistrup, Rishi Arora, Søren Grubb, Shin Yoo, Benjamin Toren, Manvinder Kumar, Aaron Kunamalla, William Marszalec, Tej Motiwala, Shannon Tai, Sean Yamakawa, Satya Yerrabolu, Francisco J Alvarado, Hector H Valdivia, Jonathan M Cordeiro, Yohannes Shiferaw, John Andrew Wasserstrom
Aims: Abnormal intracellular Ca2+ cycling contributes to triggered activity and arrhythmias in the heart. We investigated the properties and underlying mechanisms for systolic triggered Ca2+ waves in left atria from normal and failing dog hearts. Methods and results: Intracellular Ca2+ cycling was studied using confocal microscopy during rapid pacing of atrial myocytes (36 °C) isolated from normal and failing canine hearts (ventricular tachypacing model). In normal atrial myocytes (NAMs), Ca2+ waves developed during rapid pacing at rates ≥ 3...
November 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28955244/human-in-silico-drug-trials-demonstrate-higher-accuracy-than-animal-models-in-predicting-clinical-pro-arrhythmic-cardiotoxicity
#15
Elisa Passini, Oliver J Britton, Hua Rong Lu, Jutta Rohrbacher, An N Hermans, David J Gallacher, Robert J H Greig, Alfonso Bueno-Orovio, Blanca Rodriguez
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternative to experimental assays, also facilitating translation to human. Key challenges include consideration of inter-cellular variability in drug responses and integration of computational and experimental methods in safety pharmacology. Our aim is to evaluate the ability of in silico drug trials in populations of human action potential (AP) models to predict clinical risk of drug-induced arrhythmias based on ion channel information, and to compare simulation results against experimental assays commonly used for drug testing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28948147/abnormal-epicardial-electrophysiologic-substrate-in-patients-with-early-repolarization-pattern-and-reduced-left-ventricular-systolic-function-a-report-of-two-cases
#16
Siva M Krothapalli, Michael Giudici, Elaine Demetroulis, Gardar Sigurdsson, Gary Goldsmith, Alexander Mazur
No abstract text is available yet for this article.
September 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28947311/six-year-outcome-of-subjects-without-overt-heart-disease-with-an-early-repolarization-j-wave-electrocardiographic-pattern
#17
Gaetano Antonio Lanza, Alessia Argirò, Roberto Mollo, Antonio De Vita, Francesco Spera, Michele Golino, Elisabetta Rota, Monica Filice, Filippo Crea
"Early repolarization" (ER) is a frequent finding at standard electrocardiogram (ECG). In this study we assessed whether ER is associated with an increased risk of events, as recently suggested by some studies. We prospectively enrolled 4,176 consecutive subjects without any heart disease who underwent routine ECG recording. ER was diagnosed in case of typical concave ST-segment elevation ≥0.1 mV; a J wave was diagnosed when the QRS showed a notch or a slur in its terminal part. In this study we compared the 6-year outcome of all 687 subjects with ER/J wave and 687 matched subjects without ER/J wave (controls)...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28940628/identification%C3%A2-of-electrocardiographic-risk-markers-for-the-initial-and-recurrent-episodes-of-ventricular-fibrillation-in-patients-with-brugada-syndrome
#18
Hiroshi Morita, Atsuyuki Watanabe, Satoshi Kawada, Masakazu Miyamoto, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito
INTRODUCTION: New onset of ventricular fibrillation (VF) in asymptomatic patients with Brugada-type ECG is not frequent, but it cannot be negligible. Risk markers for predicting VF are usually based on results of analysis in symptomatic patients, and they have not been determined for asymptomatic patients. We analyzed ECG markers in patients with Brugada syndrome to differentiate the risk factors for VF in both symptomatic and asymptomatic patients. METHODS: The subjects were 471 patients with Brugada syndrome and we divided the subjects into two groups: Asymptomatic group (n = 326) and Symptomatic group (syncope: n = 122, VF: n = 23)...
September 22, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28931785/ventricular-fibrillation-due-to-early-repolarization-syndrome-in-the-wake-of-hypothermia-due-to-fulminant-acute-disseminated-encephalomyelitis
#19
Kyoichiro Yazaki, Yoichi Ajiro, Kunihiko Shimizu, Fumiaki Mori, Nobue Yagihara, Akinori Sato, Tatsuya Takahashi, Kazunori Iwade
No abstract text is available yet for this article.
September 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28930854/a-female-patient-with-hypokalaemia-induced-j-wave-syndrome-an-unusual-case-report
#20
Aqian Wang, Xiang Li, Muhammad Nabeel Dookhun, Tiancheng Zhang, Ping Xie, Yunshan Cao
RATIONALE: Prominent J waves can be seen in life-threatening cardiac arrhythmias such as Brugada syndrome, early repolarization syndrome, and ventricular fibrillation. We herein present an unusual case report of hypokalemia-induced J wave syndrome and ST (a part of ECG) segment elevation. PATIENTS CONCERNS: A 52-year-old woman with chief complaints of chest pain for 2 hours and diarrhea showed a marked hypokalemia (2.8 mmol/L) and slightly elevated creatine kinase-MB (CK-MB) (57...
September 2017: Medicine (Baltimore)
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