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https://www.readbyqxmd.com/read/27833161/12-months-metabolic-changes-among-gender-dysphoric-individuals-under-cross-sex-hormone-treatment-a-targeted-metabolomics-study
#1
Matthias K Auer, Alexander Cecil, Yasmin Roepke, Charlotte Bultynck, Charlotte Pas, Johannes Fuss, Cornelia Prehn, Rui Wang-Sattler, Jerzy Adamski, Günter K Stalla, Guy T'Sjoen
Metabolomic analyses in epidemiological studies have demonstrated a strong sexual dimorphism for most metabolites. Cross-sex hormone treatment (CSH) in transgender individuals enables the study of metabolites in a cross-gender setting. Targeted metabolomic profiling of serum of fasting transmen and transwomen at baseline and following 12 months of CSH (N = 20/group) was performed. Changes in 186 serum metabolites and metabolite ratios were determined by targeted metabolomics analysis based on ESI-LC-MS/MS...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27811344/evaluating-the-effectivenes-of-antiseptic-solution-decasan-in-treatment-of-necrotic-soft-tisue-diseases
#2
Julia Fuss, Victor Palii, Anna Voloboyeva
: Sepsis is a severe generalised infection caused usually by pathogenic bacteria. It is often the cause of hospitalization and death in patients treated in intensive care and other hospital wards. Latest research brought to better understanding of patomechanisms, took place significant development of therapy heading to improvement of general patients condition treated as a basis and additionally supported by local therapy. The aim of the study was to evaluate the possibility of using the solution Decasan in the comprehensive treatment of patients necrosis of soft tissues...
October 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/27768561/legal-responses-to-neuroscience
#3
Johannes Fuss
No abstract text is available yet for this article.
October 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/27748708/metabolic-imaging-in-humans
#4
Taylor L Fuss, Leo L Cheng
Metabolic imaging enhances understanding of disease metabolisms and holds great potential as a measurement tool for evaluating disease prognosis and treatment effectiveness. Advancement of techniques, such as magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry, allows for improved accuracy for quantification of metabolites and present unique possibilities for use in clinic. This article reviews and discusses literature reports of metabolic imaging in humans published since 2010 according to disease type, including cancer, degenerative disorders, psychiatric disorders, and others, as well as the current application of the various related techniques...
October 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27734300/early-effects-of-a-high-caloric-diet-and-physical-exercise-on-brain-volumetry-and-behavior-a-combined-mri-and-histology-study-in-mice
#5
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27717814/differential-associations-between-behavioral-and-cortisol-responses-to-a-stressor-in-securely-versus-insecurely-attached-infants
#6
Roseriet Beijers, Marianne Riksen-Walraven, Katharina Sebesta, Carolina de Weerth
In this study we examined whether securely versus insecurely attached infants use different regulatory behaviors in absence of their mother and whether these regulatory behaviors are differentially associated with physiological stress responses in secure versus insecure infants. Participants were 193 one-year-olds and their mothers. During three 3-min episodes of separation from the mother in the Strange Situation Procedure (SSP) [1], the following infant regulatory behaviors were observed: crying, fussing, self-soothing, manipulation of toys, and manipulation of the door...
October 4, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27709896/fast-tissue-characterization-with-quantitative-high-resolution-magic-angle-spinning-hrmas-cest-z-spectroscopy
#7
Iris Yuwen Zhou, Taylor L Fuss, Takahiro Igarashi, Weiping Jiang, Xin Zhou, Leo L Cheng, Phillip Zhe Sun
Chemical exchange saturation transfer (CEST) provides sensitive MR contrast for probing dilute compounds via exchangeable protons, serving as an emerging molecular imaging methodology. CEST Z-spectrum is often acquired by sweeping radiofrequency saturation around bulk water resonance, offset by offset, to detect CEST effects at characteristic chemical shift offsets, which requires prolonged acquisition time. Herein, combining high-resolution magic angle spinning (HRMAS) with concurrent application of gradient and RF saturation to achieve fast Z-spectral acquisition, we demonstrated the feasibility of fast quantitative HRMAS CEST Z-spectroscopy...
October 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27675785/safety-and-efficacy-of-stereotactic-body-radiation-therapy-of-accelerated-hypofractionation-for-hepatocellular-carcinoma-in-the-setting-of-advanced-liver-dysfunction
#8
N Nabavizadeh, J G Waller, R Fain, Y Chen, D A Elliott, B Mullins, I Patel, C Degnin, B A Dyer, K Farsad, J A Tanyi, M Fuss, C R Thomas, A Y Hung
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27664019/restricted-vs-unrestricted-wheel-running-in-mice-effects-on-brain-behavior-and-endocannabinoids
#9
Sarah V Biedermann, Matthias K Auer, Laura Bindila, Gabriele Ende, Beat Lutz, Wolfgang Weber-Fahr, Peter Gass, Johannes Fuss
Beneficial effects of voluntary wheel running on hippocampal neurogenesis, morphology and hippocampal-dependent behavior have widely been studied in rodents, but also serious side effects and similarities to stereotypy have been reported. Some mouse strains run excessively when equipped with running wheels, complicating the comparability to human exercise regimes. Here, we investigated how exercise restriction to 6h/day affects hippocampal morphology and metabolism, stereotypic and basal behaviors, as well as the endocannabinoid system in wheel running C57BL/6 mice; the strain most commonly used for behavioral analyses and psychiatric disease models...
September 20, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27659560/hiv-1-tat-inhibits-autotaxin-lysophospholipase-d-activity-and-modulates-oligodendrocyte-differentiation
#10
Natalie A Wheeler, Babette Fuss, Pamela E Knapp, ShiPing Zou
White matter injury has been frequently reported in HIV(+) patients. Previous studies showed that HIV-1 Tat (transactivator of transcription), a viral protein that is produced and secreted by HIV-infected cells, is toxic to young, immature oligodendrocytes (OLGs). Adding Tat to the culture medium reduced the viability of immature OLGs, and the surviving OLGs exhibited reduced process networks. OLGs produce and secrete autotaxin (ATX), an ecto-enzyme containing a lysophospholipase D (lysoPLD) activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a lipid signaling molecule that stimulates OLG differentiation...
October 2016: ASN Neuro
https://www.readbyqxmd.com/read/27609027/descriptive-figures-for-differences-in-parenting-and-infant-night-time-distress-in-the-first-three-months-of-age
#11
Ian St James-Roberts, Marion Roberts, Kimberly Hovish, Charlie Owen
: Aim To provide descriptive figures for infant distress and associated parenting at night in normal London home environments during the first three months of age. BACKGROUND: Most western infants develop long night-time sleep periods by four months of age. However, 30% of infants in many countries sleep for short periods and cry out on waking in the night: the most common type of infant sleep behaviour problem. Preventive interventions may help families and improve services...
November 2016: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/27608515/manuka-honey-in-wound-management-greater-than-the-sum-of-its-parts
#12
R White
Few involved in wound care will have escaped the considerable interest which has been generated by the resurgence in honey. Equally, there will be many clinicians around the globe who are wondering why all the fuss, as they will have been using honey all along. However, even with the advent of 'medical-grade' honey, combined with considerable research into the numerous potential modes of action, there remains a lingering scepticism regarding the value of honey as a justified, modern intervention in wound care...
September 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27572944/effect-of-restricted-pacifier-use-in-breastfeeding-term-infants-for-increasing-duration-of-breastfeeding
#13
REVIEW
Sharifah Halimah Jaafar, Jacqueline J Ho, Shayesteh Jahanfar, Mubashir Angolkar
BACKGROUND: To successfully initiate and maintain breastfeeding for a longer duration, the World Health Organization's Ten Steps to Successful Breastfeeding recommends total avoidance of artificial teats or pacifiers for breastfeeding infants. Concerns have been raised that offering the pacifier instead of the breast to calm the infant may lead to less frequent episodes of breastfeeding and as a consequence may reduce breast-milk production and shorten duration of breastfeeding. OBJECTIVES: To assess the effect of restricted versus unrestricted pacifier use in healthy full-term newborns whose mothers have initiated breastfeeding and intend to exclusively breastfeed, on the duration of breastfeeding, other breastfeeding outcomes and infant health...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27542001/precision-medicine-what-s-all-the-fuss-about
#14
Richard Barker
Precision medicine is now recognized globally as a major new era in medicine. It is being driven by advances in genomics and other 'omics' but also by the desire on the part of both health systems and governments to offer more targeted and cost-effective care. However, it faces a number of challenges, from the economics of developing more expensive companion diagnostics to the need to educate patients and the public on the advantages for them. New models of both R&D and care delivery are needed to capture the scientific, clinical and economic benefits of precision medicine...
2016: Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
https://www.readbyqxmd.com/read/27525894/antifungal-and-antibacterial-activities-of-petroselinum-crispum-essential-oil
#15
G A Linde, Z C Gazim, B K Cardoso, L F Jorge, V Tešević, J Glamoćlija, M Soković, N B Colauto
Parsley [Petroselinum crispum (Mill.) Fuss] is regarded as an aromatic, culinary, and medicinal plant and is used in the cosmetic, food, and pharmaceutical industries. However, few studies with conflicting results have been conducted on the antimicrobial activity of parsley essential oil. In addition, there have been no reports of essential oil obtained from parsley aerial parts, except seeds, as an alternative natural antimicrobial agent. Also, microorganism resistance is still a challenge for health and food production...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27466518/influence-of-chemotherapy-on-the-antioxidant-status-of-human-skin
#16
Bich Na Lee, Sora Jung, Maxim E Darvin, Jan Eucker, Dagmar Kühnhardt, Jalid Sehouli, Radoslav Chekerov, Alexa Patzelt, Harald Fuss, Ruo-Xi Yu, Jürgen Lademann
BACKGROUND: Palmoplantar erythrodysesthesia is a frequent dermal side-effect during chemotherapy. Previous investigations showed radical formation subsequent to doxorubicin infusion and preventative and therapeutic effects of an antioxidant-containing ointment. PATIENTS AND METHODS: Using a non-invasive vivomeasuring system (Biozoom®; Biozoom Services GmbH, Kassel, Germany) changes in the antioxidant status (as measured by relative carotenoid concentration) of the skin prior to and after intravenous administration of paclitaxel, docetaxel and 5-fluorouracil were investigated in 42 patients with cancer...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27453882/the-effectiveness-of-massage-therapy-in-the-treatment-of-infantile-colic-symptoms-a-randomized-controlled-trial
#17
Ali Sheidaei, Alireza Abadi, Farid Zayeri, Fatemeh Nahidi, Nafiseh Gazerani, Anita Mansouri
BACKGROUND: Infantile colic, cry-fuss and sleep problems are transient in the initial months of life, but they contribute to maternal depression, parenting stress and family mental health problems. In this randomized clinical trial, we aimed to explore the efficacy of massage therapy compared to rocking in reducing infantile colic symptoms including duration and number of cries, sleep duration and severity of infant colic. METHODS: This was a single blind RCT study with a one-week follow-up...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27452150/a-comprehensive-review-of-common-respiratory-infections-encountered-in-urgent-and-primary-care-a-reference-guide-for-judicious-antibiotic-use-with-complementary-therapies
#18
Courtney Beam, Joyce Fuss, Wendy Stoelting-Gettelfinger
No abstract text is available yet for this article.
September 2016: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/27410480/long-term-moderate-calorie-restriction-inhibits-inflammation-without-impairing-cell-mediated-immunity-a-randomized-controlled-trial-in-non-obese-humans
#19
Simin N Meydani, Sai K Das, Carl F Pieper, Michael R Lewis, Sam Klein, Vishwa D Dixit, Alok K Gupta, Dennis T Villareal, Manjushri Bhapkar, Megan Huang, Paul J Fuss, Susan B Roberts, John O Holloszy, Luigi Fontana
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function in humans. In this multi-center, randomized clinical trial to determine CR's effect on inflammation and cell-mediated immunity, 218 healthy non-obese adults (20-50 y), were assigned 25% CR (n=143) or an ad-libitum (AL) diet (n=75), and outcomes tested at baseline, 12, and 24 months of CR...
July 2016: Aging
https://www.readbyqxmd.com/read/27406037/transient-tcf3-gene-repression-by-tale-transcription-factor-targeting
#20
Junko Masuda, Hiroshi Kawamoto, Warren Strober, Eiji Takayama, Akifumi Mizutani, Hiroshi Murakami, Tomokatsu Ikawa, Atsushi Kitani, Narumi Maeno, Tsukasa Shigehiro, Ayano Satoh, Akimasa Seno, Vaidyanath Arun, Tomonari Kasai, Ivan J Fuss, Yoshimoto Katsura, Masaharu Seno
Transplantation of hematopoietic stem and progenitor cells (HSCs) i.e., self-renewing cells that retain multipotentiality, is now a widely performed therapy for many hematopoietic diseases. However, these cells are present in low number and are subject to replicative senescence after extraction; thus, the acquisition of sufficient numbers of cells for transplantation requires donors able to provide repetitive blood samples and/or methods of expanding cell numbers without disturbing cell multipotentiality. Previous studies have shown that HSCs maintain their multipotentiality and self-renewal activity if TCF3 transcription function is blocked under B cell differentiating conditions...
December 2016: Applied Biochemistry and Biotechnology
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