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https://www.readbyqxmd.com/read/29336234/haemostaseological-complication-management-in-caval-and-iliac-venous-stenting
#1
Corinne Kohler, Torsten Fuss, Ronny Schweizer, Iris Baumgartner, Nils Kucher, Marc Schindewolf
Antiplatelet and anticoagulation therapy after venous stenting is still not standardized, data from randomized-controlled trials are missing. Rare prothrombotic disorders and nonresponsiveness to drugs must be taken into account. This case report demonstrates successful haemostaselogical complication management in recurrent rethromboses due to underlying clopidogrel resistance and low responsiveness to anticoagulation with dabigatran after endovascular stent reconstruction of chronic pelvic and caval vein occlusion in a patient with severe postthrombotic syndrome...
January 16, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29300769/validation-of-an-automated-system-for-aliquoting-of-hiv-1-env-pseudotyped-virus-stocks
#2
Anke Schultz, Anja Germann, Martina Fuss, Marcella Sarzotti-Kelsoe, Daniel A Ozaki, David C Montefiori, Heiko Zimmermann, Hagen von Briesen
The standardized assessments of HIV-specific immune responses are of main interest in the preclinical and clinical stage of HIV-1 vaccine development. In this regard, HIV-1 Env-pseudotyped viruses play a central role for the evaluation of neutralizing antibody profiles and are produced according to Good Clinical Laboratory Practice- (GCLP-) compliant manual and automated procedures. To further improve and complete the automated production cycle an automated system for aliquoting HIV-1 pseudovirus stocks has been implemented...
2018: PloS One
https://www.readbyqxmd.com/read/29279326/lactobacillus-reuteri-to-treat-infant-colic-a-meta-analysis
#3
REVIEW
Valerie Sung, Frank D'Amico, Michael D Cabana, Kim Chau, Gideon Koren, Francesco Savino, Hania Szajewska, Girish Deshpande, Christophe Dupont, Flavia Indrio, Silja Mentula, Anna Partty, Daniel Tancredi
CONTEXT: Lactobacillus reuteri DSM17938 has shown promise in managing colic, but conflicting study results have prevented a consensus on whether it is truly effective. OBJECTIVE: Through an individual participant data meta-analysis, we sought to definitively determine if L reuteri DSM17938 effectively reduces crying and/or fussing time in infants with colic and whether effects vary by feeding type. DATA SOURCES: We searched online databases (PubMed, Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, the Database of Abstracts of Reviews of Effects, and Cochrane), e-abstracts, and clinical trial registries...
December 26, 2017: Pediatrics
https://www.readbyqxmd.com/read/29279316/targeting-cxcr4-cxc-chemokine-receptor-type-4-for-molecular-imaging-of-aldosterone-producing-adenoma
#4
Britta Heinze, Carmina T Fuss, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Mona Mustafa, Andreas Schirbel, Timo Deutschbein, Tracy Ann Williams, Yara Rhayem, Marcus Quinkler, Nada Rayes, Silvia Monticone, Vanessa Wild, Celso E Gomez-Sanchez, Anna-Carinna Reis, Stephan Petersenn, Hans-Juergen Wester, Saskia Kropf, Martin Fassnacht, Katharina Lang, Ken Herrmann, Andreas K Buck, Christina Bluemel, Stefanie Hahner
Primary aldosteronism is the most frequent cause of secondary hypertension and is associated with increased morbidity and mortality compared with hypertensive controls. The central diagnostic challenge is the differentiation between bilateral and unilateral disease, which determines treatment options. Bilateral adrenal venous sampling, currently recommended for differential diagnosis, is an invasive procedure with several drawbacks, making it desirable to develop novel noninvasive diagnostic tools. When investigating the expression pattern of chemokine receptors by quantitative real-time polymerase chain reaction and immunohistochemistry, we observed high expression of CXCR4 (CXC chemokine receptor type 4) in aldosterone-producing tissue in normal adrenals, adjacent adrenal cortex from adrenocortical adenomas, and in aldosterone-producing adenomas (APA), correlating strongly with the expression of CYP11B2 (aldosterone synthase)...
December 26, 2017: Hypertension
https://www.readbyqxmd.com/read/29273225/breast-density-why-all-the-fuss
#5
REVIEW
S J Vinnicombe
The term "breast density" or mammographic density (MD) denotes those components of breast parenchyma visualised at mammography that are denser than adipose tissue. MD is composed of a mixture of epithelial and stromal components, notably collagen, in variable proportions. MD is most commonly assessed in clinical practice with the time-honoured method of visual estimation of area-based percent density (PMD) on a mammogram, with categorisation into quartiles. The computerised semi-automated thresholding method, Cumulus, also yielding area-based percent density, is widely used for research purposes; however, the advent of fully automated volumetric methods developed as a consequence of the widespread use of digital mammography (DM) and yielding both absolute and percent dense volumes, has resulted in an explosion of interest in MD recently...
December 19, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29239762/bronchiolitis-what-s-all-the-fuss-about
#6
EDITORIAL
Nisa S Atigapramoj
No abstract text is available yet for this article.
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29216691/lumbar-fusion-with-collagen-type-i-and-polyvinylpyrrolidone-in-combination-with-autograft-an-experimental-study-in-new-zealand-rabbits
#7
A Reyes-Sánchez, F Reyes-Tarrago, C García-Ramos, B Zárate-Kalfópulos, E Estrada-Villaseñor, A Alpizar-Aguirre
INTRODUCTION: Multiple strategies have been developed looking for upgrading the consolidation rate of spine arthrodesis with autolog bone graft, but no evidence exists that adhesion with Collagen type 1 and polyvinylpyrrolidone (FibroquelMR) have application on this field. OBJECTIVE: Determine if collagen type 1 + Polyvinylpyrrolidone are effective as bone enhancer in posterolateral arthrodesis on rabbits. METHOD: Posterolateral arthrodesis in 15 New Zealand rabbits on level L5-L6 using autolog bone graft in left side (control group) and autolog bone graft + 1 ml FibroquelMR (study group) in right side of arthrodesis...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29216353/effects-of-sex-hormone-treatment-on-the-metabolic-syndrome-in-transgender-individuals-focus-on-metabolic-cytokines
#8
Matthias K Auer, Thomas Ebert, Maik Pietzner, Justine Defreyne, Johannes Fuss, Günter K Stalla, Guy T'Sjoen
Context: Hormone treatment (HT) in transgender persons affects many components of the metabolic syndrome (MS). Objective: To determine the role of direct hormonal effects, changes in metabolic cytokines and body composition on metabolic outcomes. Design, Setting, and Participants: 24 transwomen and 45 transmen from the European Network for the Investigation of Gender Incongruence (ENIGI) investigated at baseline and following 12 months of HT...
December 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29209003/prostate-cancer-diagnosis-and-characterization-with-mass-spectrometry-imaging
#9
REVIEW
Annika Kurreck, Lindsey A Vandergrift, Taylor L Fuss, Piet Habbel, Nathalie Y R Agar, Leo L Cheng
BACKGROUND: Prostate cancer (PCa), the most common cancer and second leading cause of cancer death in American men, presents the clinical challenge of distinguishing between indolent and aggressive tumors for proper treatment. PCa presents significant alterations in metabolic pathways that can potentially be measured using techniques like mass spectrometry (MS) or MS imaging (MSI) and used to characterize PCa aggressiveness. MS quantifies metabolomic, proteomic, and lipidomic profiles of biological systems that can be further visualized for their spatial distributions through MSI...
December 5, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29195275/functional-modification-of-silica-through-enhanced-adsorption-of-elastin-like-polypeptide-block-copolymers
#10
Linying Li, Nan K Li, Qing Tu, Owen Im, Chia-Kuei Mo, Wei Han, William Hayden Fuss, Nick J Carroll, Ashutosh Chilkoti, Yaroslava G Yingling, Stefan Zauscher, Gabriel P Lopez
A powerful tool for controlling interfacial properties and molecular architecture relies on the tailored adsorption of stimuli-responsive block copolymers onto surfaces. Here, we use computational and experimental approaches to investigate the adsorption behavior of thermally-responsive polypeptide block copolymers (elastin-like polypeptides, ELPs) onto silica surfaces, and to explore the effects of surface affinity and micellization on the adsorption kinetics and the resultant polypeptide layers. We demonstrate that genetic incorporation of a silica-binding peptide (silaffin R5) results in enhanced adsorption of these block copolymers onto silica surfaces as measured by quartz crystal microbalance and ellipsometry...
December 1, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29179633/a-concept-for-electromagnetic-navigated-targeting-of-liver-tumors-using-an-angiographic-approach
#11
Marius Schwalbe, Tom Williamson, Iwan Paolucci, Torsten Fuss, Iris Baumgartner, Daniel Candinas, Stefan Weber, Pascale Tinguely
BACKGROUND: The benefits of using navigation technology for percutaneous local ablation of selected hepatocellular carcinoma (HCC) have been shown. Due to additional efforts in the procedural workflow, barriers to introducing navigation systems on a broad clinical level remain high. In this work, initial steps toward a novel concept for simple and precise targeting of HCC are evaluated. MATERIAL AND METHODS: The proposed technique is based on an angiographic approach using an intrahepatic electromagnetic (EM) reference, for consecutive percutaneous navigated positioning of ablation probes...
November 27, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29175721/de-masking-oxytocin-deficiency-in-craniopharyngioma-and-assessing-its-link-with-affective-function
#12
Dorothea Gebert, Matthias K Auer, Mareike R Stieg, Martin T Freitag, Madlén Lahne, Johannes Fuss, Katharina Schilbach, Jochen Schopohl, Günter K Stalla, Anna Kopczak
Despite the high prevalence of panhypopituitarism and diabetes insipidus in patients with craniopharyngioma (CP), little is known about the functioning of the neuropeptide oxytocin in these patients. This is of special interest as tumor-associated lesions often impair sites critical for oxytocin production and release, and affective dysfunction in CP links with elsewhere reported prosocial, antidepressant and anxiolytic oxytocin effects. Using a prospective study-design, we tested whether oxytocin is reduced in CP-patients, and whether altered oxytocin levels account for affective and emotional dysfunction...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29118383/impact-of-lactobacillus-reuteri-colonization-on-gut-microbiota-inflammation-and-crying-time-in-infant-colic
#13
Monica L Nation, Eileen M Dunne, Shayne J Joseph, Fiona K Mensah, Valerie Sung, Catherine Satzke, Mimi L K Tang
Infant colic is a distressing condition of unknown etiology. An aberrant gastrointestinal microbiota has been associated, and Lactobacillus reuteri supplementation has been shown to reduce crying and/or fussing time ('crying time') in some infants with colic. The relationship between L. reuteri gut colonization and crying time has not been examined. We investigated the relationship between L. reuteri colonization and fecal microbiota (microbial diversity and Escherichia coli), intestinal inflammation, and crying time in infants with colic, using a subset of 65 infants from the Baby Biotics trial, which randomized healthy term infants aged <13 weeks with infant colic to receive probiotic L...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110806/masturbation-to-orgasm-stimulates-the-release-of-the-endocannabinoid-2-arachidonoylglycerol-in-humans
#14
Johannes Fuss, Laura Bindila, Klaus Wiedemann, Matthias K Auer, Peer Briken, Sarah V Biedermann
BACKGROUND: Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied. AIM: To investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29108427/what-is-all-this-fuss-about-tus-comparison-of-recent-findings-from-biophysical-and-biochemical-experiments
#15
Bojk A Berghuis, Vlad-Stefan Raducanu, Mohamed M Elshenawy, Slobodan Jergic, Martin Depken, Nicholas E Dixon, Samir M Hamdan, Nynke H Dekker
Synchronizing the convergence of the two-oppositely moving DNA replication machineries at specific termination sites is a tightly coordinated process in bacteria. In Escherichia coli, a "replication fork trap" - found within a chromosomal region where forks are allowed to enter but not leave - is set by the protein-DNA roadblock Tus-Ter. The exact sequence of events by which Tus-Ter blocks replisomes approaching from one direction but not the other has been the subject of controversy for many decades. Specific protein-protein interactions between the nonpermissive face of Tus and the approaching helicase were challenged by biochemical and structural studies...
November 6, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29065008/innovative-cardiac-devices-on-chest-imaging-an-update
#16
Anupama G Brixey, Cristina Fuss
Over the past decade, a rapidly increasing number of new cardiac devices have been created. Remaining current with these devices and how they appear on chest radiographs and other modalities used in chest imaging can be a challenge for the interpreting radiologist. This review is provides a concise summary of various common cardiac devices as well as recently developed devices that will be increasing in frequency over the coming years.
November 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29045325/effects-of-two-years-of-calorie-restriction-on-aerobic-capacity-and-muscle-strength
#17
Susan B Racette, James Rochon, Mary L Uhrich, Dennis T Villareal, Sai Krupa DAS, Luigi Fontana, Manjushri Bhapkar, Corby K Martin, Leanne M Redman, Paul J Fuss, Susan B Roberts, William E Kraus
PURPOSE: Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of CR in nonobese humans. The aim of this investigation was to determine the effects of CR on V˙O2max and muscle strength in the CALERIE trial. METHODS: Healthy, normal-weight, and mildly overweight women and men (n = 218, mean ± SE age = 37...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29032808/torso-geometry-reconstruction-and-body-surface-electrode-localization-using-three-dimensional-photography
#18
Erick A Perez-Alday, Jason A Thomas, Muammar Kabir, Golriz Sedaghat, Nichole Rogovoy, Eelco van Dam, Peter van Dam, William Woodward, Cristina Fuss, Maros Ferencik, Larisa G Tereshchenko
We conducted a prospective clinical study (n=14; 29% female) to assess the accuracy of a three-dimensional (3D) photography-based method of torso geometry reconstruction and body surface electrodes localization. The position of 74 body surface electrocardiographic (ECG) electrodes (diameter 5mm) was defined by two methods: 3D photography, and CT (marker diameter 2mm) or MRI (marker size 10×20mm) imaging. Bland-Altman analysis showed good agreement in X (bias -2.5 [95% limits of agreement (LoA) -19.5 to 14...
September 1, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28969890/lactobacillus-reuteri-for-infants-with-colic-a-double-blind-placebo-controlled-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Nicole Y Fatheree, Yuying Liu, Christopher M Taylor, Thomas K Hoang, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Michael Ferris, Valarie McMurtry, Christine Wong, Ta Vu, Theresa Dancsak, Ting Wang, Wallace Gleason, Vinay Bandla, Fernando Navarro, Dat Q Tran, J Marc Rhoads
OBJECTIVE: To assess the safety of probiotic Lactobacillus reuteri strain Deutsche Sammlung von Mikroorganismen (DSM) 17938 with daily administration to healthy infants with colic and to determine the effect of L reuteri strain DSM 17938 on crying, fussing, inflammatory, immune, and microbiome variables. STUDY DESIGN: We performed a controlled, double-blinded, phase 1 safety and tolerability trial in healthy breast-fed infants with colic, aged 3 weeks to 3 months, randomly assigned to L reuteri strain DSM 17938 (5 × 108 colony-forming units daily) or placebo for 42 days and followed for 134 days...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28895249/salt-responsive-morphologies-of-ssdna-based-triblock-polyelectrolytes-in-semi-dilute-regime-effect-of-volume-fractions-and-polyelectrolyte-length
#20
Nan K Li, Huihui Kuang, William H Fuss, Stefan Zauscher, Efrosini Kokkoli, Yaroslava G Yingling
A comprehensive study is reported on the effect of salt concentration, polyelectrolyte block length, and polymer concentration on the morphology and structural properties of nanoaggregates self-assembled from BAB single-strand DNA (ssDNA) triblock polynucleotides in which A represents polyelectrolyte blocks and B represents hydrophobic neutral blocks. A morphological phase diagram above the gelation point is developed as a function of solvent ionic strength and polyelectrolyte block length utilizing an implicit solvent ionic strength method for dissipative particle dynamics simulations...
September 12, 2017: Macromolecular Rapid Communications
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