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https://www.readbyqxmd.com/read/28301071/applications-of-high-resolution-magic-angle-spinning-mrs-in-biomedical-studies-i-cell-line-and-animal-models
#1
REVIEW
Eva Kaebisch, Taylor L Fuss, Lindsey A Vandergrift, Karin Toews, Piet Habbel, Leo L Cheng
High-resolution magic angle spinning (HRMAS) MRS allows for direct measurements of non-liquid tissue and cell specimens to present valuable insights into the cellular metabolisms of physiological and pathological processes. HRMAS produces high-resolution spectra comparable to those obtained from solutions of specimen extracts but without complex metabolite extraction processes, and preserves the tissue cellular structure in a form suitable for pathological examinations following spectroscopic analysis. The technique has been applied in a wide variety of biomedical and biochemical studies and become one of the major platforms of metabolomic studies...
March 16, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28261843/tools-assessment-and-diagnosis-to-infant-colic-a-systematic-review
#2
REVIEW
S García Marqués, R Chillón Martínez, S González Zapata, M Rebollo Salas, J J Jiménez Rejano
BACKGROUND: Infant colic occurs between 10% and 40% of healthy born children in their first year of life. Its assessment is complex, and there are only a few instruments of appraisement and diagnosis. METHODS: Scientific articles located through a systematic review using the Pubmed, Scopus, Cochrane, PEDro, Dialnet, IME and Dialnet databases. Two researchers obtained data independently from relevant studies previously identified. Risk of bias was assessed according to the methods recommended by the Cochrane Collaboration, with reporting following the preferred reported items for systematic reviews and meta-analyses guidelines and evaluating their methodological quality based on the EMPRO scale...
March 5, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28228420/body-composition-changes-in-the-comprehensive-assessment-of-long-term-effects-of-reducing-intake-of-energy-calerie-2-study-a-2-y-randomized-controlled-trial-of-calorie-restriction-in-nonobese-humans
#3
Sai Krupa Das, Susan B Roberts, Manjushri V Bhapkar, Dennis T Villareal, Luigi Fontana, Corby K Martin, Susan B Racette, Paul J Fuss, William E Kraus, William W Wong, Edward Saltzman, Carl F Pieper, Roger A Fielding, Ann V Schwartz, Eric Ravussin, Leanne M Redman
Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regimen on body composition including the influence of sex and body mass index (BMI; in kg/m(2)) among participants enrolled in CALERIE-2 (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), a multicenter, randomized controlled trial.Design: Participants were 218 nonobese (BMI: 21...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28220153/high-throughput-flowing-upstream-sperm-sorting-in-a-retarding-flow-field-for-human-semen-analysis
#4
Jen-Kuei Wu, Peng-Chun Chen, Yu-Nan Lin, Chia-Woei Wang, Li-Chern Pan, Fan-Gang Tseng
In this paper, we propose a microfluidic device capable of generating a retarding flow field for the sorting and separation of human motile sperm in a high-throughput manner. The proposed sorting/separation process begins with a rapid flow field in a straight-flow zone to carry sperm into a sorting zone to maintain the sperm's mobility. The sorting zone consists of a diffuser-type sperm sorter to differentiate sperm with different motilities based on the flowing upstream nature of human sperm in a retarding flow field...
March 13, 2017: Analyst
https://www.readbyqxmd.com/read/28215545/associations-of-parental-food-choice-control-and-use-of-food-to-soothe-with-adiposity-in-childhood-and-adolescence
#5
Shiau Y Chong, Catherine R Chittleborough, Tess Gregory, John W Lynch, Murthy N Mittinty, Lisa G Smithers
BACKGROUND: Associations of parental feeding techniques with adiposity are mixed and largely rely on cross-sectional studies. We examined associations between parental food-choice control and using food to soothe at 3.5 years on adiposity at 7 and 15 years. METHODS: Participants were from the Avon Longitudinal Study of Parents and Children (n = 7312). Food-choice control was assessed using the item 'how much choice do you allow him/her in deciding what foods he eats at meals?'...
February 16, 2017: Appetite
https://www.readbyqxmd.com/read/28199359/high-impact-of-sleeping-problems-on-quality-of-life-in-transgender-individuals-a-cross-sectional-multicenter-study
#6
Matthias K Auer, Anita Liedl, Johannes Fuss, Timo Nieder, Peer Briken, Günter K Stalla, Thomas Hildebrandt, Sarah V Biedermann, Caroline Sievers
INTRODUCTION: Studies in the general population suggest that determinants of QoL are often sex-dependent. Sex-dependent analyses of QoL in transgender populations have not been performed so far. AIM: To identify sex-specific and potentially modifiable determinants of QoL in transgender patients. METHODS: In this cross-sectional multicentre study including 82 transwomen (TW) and 72 transmen (TM) at different treatment stages, we investigated potential determinants for QoL focusing on the impact of mood (BDI, STAI-X), sleep quality (PSQI), chronic pain (GPQ), body image (FBeK) and social support (SSS)...
2017: PloS One
https://www.readbyqxmd.com/read/28093383/effect-of-minimal-acupuncture-for-infantile-colic-a-multicentre-three-armed-single-blind-randomised-controlled-trial-acu-col
#7
Kajsa Landgren, Inger Hallström
BACKGROUND: Evidence for treating infantile colic with acupuncture is contradictory. AIM: To evaluate and compare the effect of two types of acupuncture versus no acupuncture in infants with colic in public child health centres (CHCs). METHODS: A multicentre, randomised controlled, single-blind, three-armed trial (ACU-COL) comparing two styles of acupuncture with no acupuncture, as an adjunct to standard care, was conducted. Among 426 infants whose parents sought help for colic and registered their child's fussing/crying in a diary, 157 fulfilled the criteria for colic and 147 started the intervention...
January 16, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28073180/portosystemic-collaterals-in-living-donor-liver-transplantation-what-is-all-the-fuss-about
#8
Mettu Srinivas Reddy, Mohamed Rela
Portosystemic collaterals are a common finding in patients with cirrhosis undergoing liver transplantation. Recently, there has been a renewed interest regarding their significance in the setting of living donor liver transplantation (LDLT) due to concerns of graft hypoperfusion or hyperperfusion and its impact on early posttransplant outcomes. Presence of these collaterals has greater significance in the LDLT setting when compared with the deceased donor liver transplantation setting as dictated by the difference in the physiology of partial liver grafts...
April 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28048726/tu-d-201-01-2016-economics-update
#9
J Fontenot, W Fuss
The purpose of this session is to introduce attendees to the healthcare reimbursement system and how it applies to the clinical work of a medical physicist. This will include general information about the different categories of payers and payees, how work is described by CPT codes, and how various payers set values for this work in different clinical settings. 2016 is another year of significant changes to the payment system. This presentation will describe the work encompassed in these codes and will give attendees an overview of the changes for 2016 as they apply to radiation oncology...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027671/nutrition-status-of-primary-school-students-in-two-rural-regions-of-guinea-bissau
#10
Edward Saltzman, Nina Schlossman, Carrie A Brown, Ionela Balan, Paul Fuss, Payal Batra, Augusto Braima de Sa, Mary Kyla Shea, William M Pruzensky, Carlito Bale, Susan B Roberts
BACKGROUND: The nutrition status of primary schoolchildren in Africa has received relatively little attention in comparison to that of younger children. We surveyed primary school students in Guinea-Bissau, a nation that is among the poorest in the world. OBJECTIVE: Anthropometry and prevalence of anemia and vitamin A deficiency were assessed in schoolchildren participating in International Partnership for Human Development's school feeding program in 2 regions of Guinea-Bissau...
January 1, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27833161/12-months-metabolic-changes-among-gender-dysphoric-individuals-under-cross-sex-hormone-treatment-a-targeted-metabolomics-study
#11
Matthias K Auer, Alexander Cecil, Yasmin Roepke, Charlotte Bultynck, Charlotte Pas, Johannes Fuss, Cornelia Prehn, Rui Wang-Sattler, Jerzy Adamski, Günter K Stalla, Guy T'Sjoen
Metabolomic analyses in epidemiological studies have demonstrated a strong sexual dimorphism for most metabolites. Cross-sex hormone treatment (CSH) in transgender individuals enables the study of metabolites in a cross-gender setting. Targeted metabolomic profiling of serum of fasting transmen and transwomen at baseline and following 12 months of CSH (N = 20/group) was performed. Changes in 186 serum metabolites and metabolite ratios were determined by targeted metabolomics analysis based on ESI-LC-MS/MS...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27811344/evaluating-the-effectivenes-of-antiseptic-solution-decasan-in-treatment-of-necrotic-soft-tisue-diseases
#12
Julia Fuss, Victor Palii, Anna Voloboyeva
Sepsis is a severe generalised infection caused usually by pathogenic bacteria. It is often the cause of hospitalization and death in patients treated in intensive care and other hospital wards. Latest research brought to better understanding of patomechanisms, took place significant development of therapy heading to improvement of general patients condition treated as a basis and additionally supported by local therapy. The aim of the study was to evaluate the possibility of using the solution Decasan in the comprehensive treatment of patients necrosis of soft tissues...
October 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/27768561/legal-responses-to-neuroscience
#13
Johannes Fuss
No abstract text is available yet for this article.
October 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/27748708/metabolic-imaging-in-humans
#14
Taylor L Fuss, Leo L Cheng
Metabolic imaging enhances understanding of disease metabolisms and holds great potential as a measurement tool for evaluating disease prognosis and treatment effectiveness. Advancement of techniques, such as magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry, allows for improved accuracy for quantification of metabolites and present unique possibilities for use in clinic. This article reviews and discusses literature reports of metabolic imaging in humans published since 2010 according to disease type, including cancer, degenerative disorders, psychiatric disorders, and others, as well as the current application of the various related techniques...
October 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27734300/early-effects-of-a-high-caloric-diet-and-physical-exercise-on-brain-volumetry-and-behavior-a-combined-mri-and-histology-study-in-mice
#15
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27717814/differential-associations-between-behavioral-and-cortisol-responses-to-a-stressor-in-securely-versus-insecurely-attached-infants
#16
Roseriet Beijers, Marianne Riksen-Walraven, Katharina Sebesta, Carolina de Weerth
In this study we examined whether securely versus insecurely attached infants use different regulatory behaviors in absence of their mother and whether these regulatory behaviors are differentially associated with physiological stress responses in secure versus insecure infants. Participants were 193 one-year-olds and their mothers. During three 3-min episodes of separation from the mother in the Strange Situation Procedure (SSP) [1], the following infant regulatory behaviors were observed: crying, fussing, self-soothing, manipulation of toys, and manipulation of the door...
October 4, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27709896/tissue-characterization-with-quantitative-high-resolution-magic-angle-spinning-chemical-exchange-saturation-transfer-z-spectroscopy
#17
Iris Yuwen Zhou, Taylor L Fuss, Takahiro Igarashi, Weiping Jiang, Xin Zhou, Leo L Cheng, Phillip Zhe Sun
Chemical exchange saturation transfer (CEST) provides sensitive magnetic resonance (MR) contrast for probing dilute compounds via exchangeable protons, serving as an emerging molecular imaging methodology. CEST Z-spectrum is often acquired by sweeping radiofrequency saturation around bulk water resonance, offset by offset, to detect CEST effects at characteristic chemical shift offsets, which requires prolonged acquisition time. Herein, combining high-resolution magic angle spinning (HRMAS) with concurrent application of gradient and rf saturation to achieve fast Z-spectral acquisition, we demonstrated the feasibility of fast quantitative HRMAS CEST Z-spectroscopy...
November 1, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27675785/safety-and-efficacy-of-stereotactic-body-radiation-therapy-of-accelerated-hypofractionation-for-hepatocellular-carcinoma-in-the-setting-of-advanced-liver-dysfunction
#18
N Nabavizadeh, J G Waller, R Fain, Y Chen, D A Elliott, B Mullins, I Patel, C Degnin, B A Dyer, K Farsad, J A Tanyi, M Fuss, C R Thomas, A Y Hung
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27664019/restricted-vs-unrestricted-wheel-running-in-mice-effects-on-brain-behavior-and-endocannabinoids
#19
Sarah V Biedermann, Matthias K Auer, Laura Bindila, Gabriele Ende, Beat Lutz, Wolfgang Weber-Fahr, Peter Gass, Johannes Fuss
Beneficial effects of voluntary wheel running on hippocampal neurogenesis, morphology and hippocampal-dependent behavior have widely been studied in rodents, but also serious side effects and similarities to stereotypy have been reported. Some mouse strains run excessively when equipped with running wheels, complicating the comparability to human exercise regimes. Here, we investigated how exercise restriction to 6h/day affects hippocampal morphology and metabolism, stereotypic and basal behaviors, as well as the endocannabinoid system in wheel running C57BL/6 mice; the strain most commonly used for behavioral analyses and psychiatric disease models...
November 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27659560/hiv-1-tat-inhibits-autotaxin-lysophospholipase-d-activity-and-modulates-oligodendrocyte-differentiation
#20
Natalie A Wheeler, Babette Fuss, Pamela E Knapp, ShiPing Zou
White matter injury has been frequently reported in HIV(+) patients. Previous studies showed that HIV-1 Tat (transactivator of transcription), a viral protein that is produced and secreted by HIV-infected cells, is toxic to young, immature oligodendrocytes (OLGs). Adding Tat to the culture medium reduced the viability of immature OLGs, and the surviving OLGs exhibited reduced process networks. OLGs produce and secrete autotaxin (ATX), an ecto-enzyme containing a lysophospholipase D (lysoPLD) activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a lipid signaling molecule that stimulates OLG differentiation...
October 2016: ASN Neuro
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