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https://www.readbyqxmd.com/read/29748345/parents-experience-when-their-child-has-chronic-abdominal-pain-a-qualitative-study-in-norway
#1
Anne Brodwall, Kari Glavin, Per Lagerløv
OBJECTIVE: Functional abdominal pain occurs frequently in children and adolescents. It is an exclusion diagnosis; somatic diseases have to be ruled out. However little explanation is given for why the child is experiencing pain. The aim was to explore the experiences of parents of children with chronic abdominal pain discharged from hospital without a somatic explanation. DESIGN: The study has a qualitative design. The open questions concerned pain experiences and management...
May 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29725306/muscle-performance-investigated-with-a-novel-smart-compression-garment-based-on-pressure-sensor-force-myography-and-its-validation-against-emg
#2
Aaron Belbasis, Franz Konstantin Fuss
Muscle activity and fatigue performance parameters were obtained and compared between both a smart compression garment and the gold-standard, a surface electromyography (EMG) system during high-speed cycling in seven participants. The smart compression garment, based on force myography (FMG), comprised of integrated pressure sensors that were sandwiched between skin and garment, located on five thigh muscles. The muscle activity was assessed by means of crank cycle diagrams (polar plots) that displayed the muscle activity relative to the crank cycle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29712629/recommendations-for-assessment-of-the-reliability-sensitivity-and-validity-of-data-provided-by-wearable-sensors-designed-for-monitoring-physical-activity
#3
Peter Düking, Franz Konstantin Fuss, Hans-Christer Holmberg, Billy Sperlich
Although it is becoming increasingly popular to monitor parameters related to training, recovery, and health with wearable sensor technology (wearables), scientific evaluation of the reliability, sensitivity, and validity of such data is limited and, where available, has involved a wide variety of approaches. To improve the trustworthiness of data collected by wearables and facilitate comparisons, we have outlined recommendations for standardized evaluation. We discuss the wearable devices themselves, as well as experimental and statistical considerations...
April 30, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29699760/desire-to-have-children-among-transgender-people-in-germany-a-cross-sectional-multi-center-study
#4
Matthias K Auer, Johannes Fuss, Timo O Nieder, Peer Briken, Sarah V Biedermann, Günter K Stalla, Matthias W Beckmann, Thomas Hildebrandt
BACKGROUND: Many trans individuals undergo medical interventions that result in irreversible loss of fertility. Little is known about their desire to have children and attitudes toward fertility preservation options. AIM: To study how the desire for children and the use of fertility preservation options varies among trans women and trans men in different transitioning stages in Germany. METHODS: In this cross-sectional multi-center study, N = 99 trans women and N = 90 trans men were included...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29683349/video-rethinking-mural-thickening-vasculitis-or-aortic-dissection
#5
Caitlin A Harrington, Alexander A Brescia, Brandon H Tieu, Cristina Fuss
OBJECTIVE: The objective of this video article is to provide education about the similarities and differences between vasculitis and rare, acute aortic pathologic findings so that an appropriate diagnosis can be made in a timely manner, especially for patients with life-threatening aortic pathologic findings. CONCLUSION: Although they are rare, acute aortic pathologic findings, such as aortic dissection and intramural hematoma, can have radiographic characteristics similar to those of vasculitis, which can make it challenging to discern between these vastly different diagnoses without the use of properly timed imaging studies...
May 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29662188/author-correction-gender-bias-in-clinicians-pathologization-of-atypical-sexuality-a-randomized-controlled-trial-with-mental-health-professionals
#6
Johannes Fuss, Peer Briken, Verena Klein
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29581441/metabolomic-prediction-of-human-prostate-cancer-aggressiveness-magnetic-resonance-spectroscopy-of-histologically-benign-tissue
#7
Lindsey A Vandergrift, Emily A Decelle, Johannes Kurth, Shulin Wu, Taylor L Fuss, Elita M DeFeo, Elkan F Halpern, Matthias Taupitz, W Scott McDougal, Aria F Olumi, Chin-Lee Wu, Leo L Cheng
Prostate cancer alters cellular metabolism through events potentially preceding cancer morphological formation. Magnetic resonance spectroscopy (MRS)-based metabolomics of histologically-benign tissues from cancerous prostates can predict disease aggressiveness, offering clinically-translatable prognostic information. This retrospective study of 185 patients (2002-2009) included prostate tissues from prostatectomies (n = 365), benign prostatic hyperplasia (BPH) (n = 15), and biopsy cores from cancer-negative patients (n = 14)...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523538/why-all-the-fuss-about-paediatric-acl-rupture-isn-t-the-meniscus-much-more-important
#8
EDITORIAL
Nicholas Mohtadi, Clare L Ardern, Lars Engebretsen
No abstract text is available yet for this article.
April 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29503447/lin28b-enhanced-tumorigenesis-in-an-autochthonous-kras-g12v-driven-lung-carcinoma-mouse-model
#9
Lydia Meder, Katharina König, Felix Dietlein, Iris Macheleidt, Alexandra Florin, Meryem S Ercanoglu, Ursula Rommerscheidt-Fuss, Mirjam Koker, Gisela Schön, Margarete Odenthal, Florian Klein, Reinhard Büttner, Johannes H Schulte, Lukas C Heukamp, Roland T Ullrich
LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance, and poor outcome in several solid cancers, including lung cancer. However, the functional role of LIN28B, especially in non-small cell lung adenocarcinomas, remains elusive. Here, we investigated the effects of LIN28B expression on lung tumorigenesis using LIN28B transgenic overexpression in an autochthonous KRASG12V -driven mouse model...
March 5, 2018: Oncogene
https://www.readbyqxmd.com/read/29487534/discovery-of-a-sweet-spot-on-the-foot-with-a-smart-wearable-soccer-boot-sensor-that-maximizes-the-chances-of-scoring-a-curved-kick-in-soccer
#10
Franz Konstantin Fuss, Peter Düking, Yehuda Weizman
This paper provides the evidence of a sweet spot on the boot/foot as well as the method for detecting it with a wearable pressure sensitive device. This study confirmed the hypothesized existence of sweet and dead spots on a soccer boot or foot when kicking a ball. For a stationary curved kick, kicking the ball at the sweet spot maximized the probability of scoring a goal (58-86%), whereas having the impact point at the dead zone minimized the probability (11-22%). The sweet spot was found based on hypothesized favorable parameter ranges (center of pressure in x/y-directions and/or peak impact force) and the dead zone based on hypothesized unfavorable parameter ranges...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29487335/gender-bias-in-clinicians-pathologization-of-atypical-sexuality-a-randomized-controlled-trial-with-mental-health-professionals
#11
Johannes Fuss, Peer Briken, Verena Klein
The psychiatric classification of "normal" versus disordered sexual behavior has been a subject of some dispute. Although atypical sexual interests have been viewed traditionally as typically male, epidemiological data indicate its presence in both genders. We examined how gender and sexual orientation influence whether or not atypical sexual behavior is classified as a mental disorder. Mental health professionals (N = 546) were presented with five case vignettes where subjects exhibit paraphilic behaviors; one case with psychotic symptoms served as the control condition...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463917/infant-temperament-and-parent-use-of-food-to-soothe-predict-change-in-weight-for-length-across-infancy-early-risk-factors-for-childhood-obesity
#12
Cynthia A Stifter, Kameron J Moding
OBJECTIVES: Greater weight gain in infancy is a risk factor for childhood obesity. The present study examined the interaction between infant temperament and parent use of food to soothe infant distress (FTS) as predictors of weight gain across the first 2 years of life. SUBJECTS/METHODS: A total of 160 mother-infant dyads were recruited into a longitudinal study. Infant temperament was assessed by parents through a questionnaire (surgency, negativity) and by observer ratings (surgency, irritability) during a laboratory visit when infants were 6 months old...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29444255/identification-of-the-dna-methyltransferases-establishing-the-methylome-of-the-cyanobacterium-synechocystis-sp-pcc-6803
#13
Martin Hagemann, Katrin Gärtner, Matthias Scharnagl, Paul Bolay, Steffen C Lott, Janina Fuss, Bruno Huettel, Richard Reinhardt, Stephan Klähn, Wolfgang R Hess
DNA methylation in bacteria is important for defense against foreign DNA, but is also involved in DNA repair, replication, chromosome partitioning, and regulatory processes. Thus, characterization of the underlying DNA methyltransferases in genetically tractable bacteria is of paramount importance. Here, we characterized the methylome and orphan methyltransferases in the model cyanobacterium Synechocystis sp. PCC 6803. Single molecule real-time (SMRT) sequencing revealed four DNA methylation recognition sequences in addition to the previously known motif m5CGATCG, which is recognized by M...
February 12, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29431578/patency-of-the-arterial-pedal-plantar-arch-in-patients-with-chronic-kidney-disease-or-diabetes-mellitus
#14
Axel Haine, Alan G Haynes, Andreas Limacher, Tim Sebastian, Wuttichai Saengprakai, Torsten Fuss, Iris Baumgartner
BACKGROUND: Patency of the pedal-plantar arch limits risk of amputation in peripheral artery disease (PAD). We examined patients without chronic kidney disease (CKD)/diabetes mellits (DM) [PAD-control], those with DM without CKD, and those with CKD without DM. METHOD: Uni- and multivariate logistic regression was used to assess association of CKD with loss of patency of the pedal-plantar arch and presence of tibial or peroneal vessel occlusion. Multivariate models adjusted for age, sex, hypertension, hyperlipidemia and smoking...
May 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29422195/practice-based-interpretation-of-ultrasound-studies-leads-the-way-to-more-effective-clinical-support-and-less-pharmaceutical-and-surgical-intervention-for-breastfeeding-infants
#15
REVIEW
Pamela Douglas, Donna Geddes
BACKGROUND: breastfeeding optimises health outcomes for both mothers and infants. Although most women want to breastfeed, they report commencing infant formula because of nipple pain, unsettled infant behaviour, and infant growth concerns. To date, existing approaches to fit and hold ('latch and positioning') have been demonstrated not to help breastfeeding outcomes, and women report widespread dissatisfaction with the quality of support and conflicting advice they receive. Breast and nipple pain, difficulty with latching and sucking, fussing at the breast, back-arching, marathon feeds, excessively frequent feeds, poor weight gain, breast refusal, and crying due to poor satiety often signal suboptimal positional instability and impaired milk transfer, but may be misdiagnosed as medical conditions...
March 2018: Midwifery
https://www.readbyqxmd.com/read/29413273/safety-and-efficacy-of-accelerated-hypofractionation-and-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-patients-with-varying-degrees-of-hepatic-impairment
#16
Nima Nabavizadeh, Joseph G Waller, Robert Fain, Yiyi Chen, Catherine R Degnin, David A Elliott, Brandon T Mullins, Ishan A Patel, Brandon A Dyer, Kareem Fakhoury, Willscott E Naugler, Khashayar Farsad, James A Tanyi, Martin Fuss, Charles R Thomas, Arthur Y Hung
PURPOSE: To report the toxicities and outcomes for stereotactic body radiation therapy (SBRT) and accelerated hypofractionated radiation therapy (AHRT) in patients with Child-Pugh (CP) class A, B, or C and albumin-bilirubin (ALBI) score 1, 2, or 3 hepatocellular carcinoma. METHODS AND MATERIALS: We retrospectively reviewed the data from 146 patients with hepatocellular carcinoma who had undergone SBRT (50 Gy in 5 fractions) or AHRT (45 Gy in 18 fractions). The primary endpoint was liver toxicity, defined as an increase in the CP score of ≥2 within 6 months of radiation therapy...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29408806/loss-of-function-card8-mutation-causes-nlrp3-inflammasome-activation-and-crohn-s-disease
#17
Liming Mao, Atsushi Kitani, Morgan Similuk, Andrew J Oler, Lindsey Albenberg, Judith Kelsen, Atiye Aktay, Martha Quezado, Michael Yao, Kim Montgomery-Recht, Ivan J Fuss, Warren Strober
In these studies, we evaluated the contribution of the NLRP3 inflammasome to Crohn's disease (CD) in a kindred containing individuals having a missense mutation in CARD8, a protein known to inhibit this inflammasome. Whole exome sequencing and PCR studies identified the affected individuals as having a V44I mutation in a single allele of the T60 isoform of CARD8. The serum levels of IL-1β in the affected individuals were increased compared with those in healthy controls, and their peripheral monocytes produced increased amounts of IL-1β when stimulated by NLRP3 activators...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29386082/what-s-the-fuss-about-parent-presentations-of-fussy-eating-to-a-parenting-support-helpline
#18
Holly A Harris, Bonnie Ria-Searle, Elena Jansen, Karen Thorpe
OBJECTIVE: To characterise parent presentations of fussy eating and mealtime interactions at a point of crisis, through analyses of real-time recordings of calls to a parenting helpline. DESIGN: Qualitative analysis included an inductive thematic approach to examine clinical parent presentations of fussy eating and derive underlying themes relating to mealtime interactions. SETTING: Calls made to the Child Health Line regarding feeding concerns were recorded and transcribed verbatim...
February 1, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29368275/genetic-counseling-in-the-era-of-genomics-what-s-all-the-fuss-about
#19
Gemma R Brett, Ella J Wilkins, Emma T Creed, Kirsty West, Anna Jarmolowicz, Giulia M Valente, Yael Prawer, Elly Lynch, Ivan Macciocca
As genomic sequencing becomes more widely available in clinical settings for diagnostic purposes, a number of genetic counseling issues are gaining precedence. The ability to manage these issues will be paramount as genetic and non-genetic healthcare professionals navigate the complexities of using genomic technologies to facilitate diagnosis and inform patient management. Counseling issues arising when counseling for diagnostic genomic sequencing were identified by four genetic counselors with 10 years of collective experience providing genetic counseling in this setting...
January 24, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29355026/efficacy-outcomes-of-endovascular-versus-surgical-revascularization-in-critical-limb-ischemia-results-from-a-prospective-cohort-study
#20
Marc Schindewolf, Torsten Fuss, Hanspeter Fink, Armin Gemperli, Axel Haine, Iris Baumgartner
Data on efficacy outcomes of endovascular versus surgical revascularization in patients with critical limb ischemia (CLI) in contemporary practice are limited. In this prospective cohort study, 353 consecutive patients with CLI were enrolled and allocated to endovascular (PTA [percutaneous transluminal angioplasty]), surgical (SURG), or no revascularization (No REVASC) after interdisciplinary consensus. Outcome measures were sustained primary clinical success (sPCS; survival without major amputation, repeated target extremity revascularization, and freedom from CLI), limb salvage, and amputation-free survival...
January 1, 2018: Angiology
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