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https://www.readbyqxmd.com/read/28807045/a-randomized-multi-center-prospective-study-comparing-best-medical-treatment-versus-best-medical-treatment-plus-renal-artery-stenting-in-patients-with-hemodynamically-relevant-atherosclerotic-renal-artery-stenosis-radar-one-year-results-of-a-pre-maturely-terminated
#1
Thomas Zeller, Hans Krankenberg, Andrejs Erglis, Erwin Blessing, Torsten Fuss, Dierk Scheinert, Ralf Weser, Beatrix B Doerr, Wilfrid D Yollo, Joerg Radermacher
BACKGROUND: The indications for conservative "best medical treatment" (BMT) versus additional renal artery stenting are a matter of ongoing debate. The RADAR study aimed to evaluate the impact of percutaneous renal artery stenting on the impaired renal function in patients with hemodynamically significant atherosclerotic renal artery stenosis (RAS). METHODS: RADAR is an international, prospective, randomized (1:1) controlled study comparing BMT alone versus BMT plus renal artery stenting in patients with duplex sonographic hemodynamically relevant RAS...
August 14, 2017: Trials
https://www.readbyqxmd.com/read/28731660/-excessive-crying-in-infants-in-the-first-months-of-life-review
#2
REVIEW
Patricio Kenny
Cry-fuss problems are among the most common clinical presentations in the first few months of life. Cry-fuss behaviour emerges out of a complex interplay of cultural, psychosocial, environmental and biologic factors, with organic disturbance implicated in only 5% of cases. A holistic biopsychosocial approach can be most effective. This article reviews recent evidence to update clinical management, and will attempt to reconceptualize infant colic definition.
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28717156/patterned-arrangements-of-olfactory-receptor-gene-expression-in-zebrafish-are-established-by-radial-movement-of-specified-olfactory-sensory-neurons
#3
Xalid Bayramli, Yiğit Kocagöz, Uğurcan Sakizli, Stefan H Fuss
Spatial restriction of olfactory receptor (OR) gene expression in peripheral sense organs is a common phenomenon across species, suggesting that zonal OR expression somehow contributes to olfactory function. In zebrafish OR expression patterns reminiscent of zones occur as concentric domains with preferred diameters for different ORs. However, the function and the developmental origin of the pattern are unknown. Here we investigate olfactory sensory neuron (OSN) neurogenesis in the adult zebrafish olfactory epithelium (OE) to understand how the zonally organized OR pattern is established and maintained during the lifetime of the animal...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28712674/the-ebbinghaus-illusion-in-the-gray-bamboo-shark-chiloscyllium-griseum-in-comparison-to-the-teleost-damselfish-chromis-chromis
#4
Theodora Fuss, Vera Schluessel
This is the first study to comparatively assess the perception of the Ebbinghaus-Titchener circles and variations of the Delboeuf illusion in four juvenile bamboo sharks (Chiloscyllium griseum) and five damselfish (Chromis chromis) using identical training paradigms. We aimed to investigate whether these two species show similarities in the perceptual integration of local elements into the global context. The Ebbinghaus-Titchener circles consist of two equally sized central test circles surrounded by smaller or larger circles of different size, number and/or distance...
May 29, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28683833/effectiveness-of-skin-to-skin-contact-versus-care-as-usual-in-mothers-and-their-full-term-infants-study-protocol-for-a-parallel-group-randomized-controlled-trial
#5
Kelly H M Cooijmans, Roseriet Beijers, Anne C Rovers, Carolina de Weerth
BACKGROUND: Twenty-to-forty percent of women experience postpartum depressive symptoms, which can affect both the mother and infant. In preterm infants, daily skin-to-skin contact (SSC) between the mother and her infant has been shown to decrease maternal postpartum depressive symptoms. In full-term infants, only two studies investigated SSC effects on maternal depressive symptoms and found similar results. Research in preterm infants also showed that SSC improves other mental and physical health outcomes of the mother and the infant, and improves the quality of mother-infant relationship...
July 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28668116/macrobac-new-technologies-for-robust-and-efficient-large-scale-production-of-recombinant-multiprotein-complexes
#6
Scott D Gradia, Justin P Ishida, Miaw-Sheue Tsai, Chris Jeans, John A Tainer, Jill O Fuss
Recombinant expression of large, multiprotein complexes is essential and often rate limiting for determining structural, biophysical, and biochemical properties of DNA repair, replication, transcription, and other key cellular processes. Baculovirus-infected insect cell expression systems are especially well suited for producing large, human proteins recombinantly, and multigene baculovirus systems have facilitated studies of multiprotein complexes. In this chapter, we describe a multigene baculovirus system called MacroBac that uses a Biobricks-type assembly method based on restriction and ligation (Series 11) or ligation-independent cloning (Series 438)...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28653108/prevention-of-palmoplantar-erythrodysesthesia-in-patients-treated-with-pegylated-liposomal-doxorubicin-caelyx%C3%A2
#7
S Jung, J Sehouli, R Chekerov, F Kluschke, A Patzelt, H Fuss, F Knorr, J Lademann
PURPOSE: Palmoplantar erythrodysesthesia (PPE) is one of the most frequent side effects during systemic treatment with pegylated liposomal doxorubicin (PLD, Caelyx®). PPE lesions show a range of symptoms, from numbness to painful erosions, and can have a major impact on the quality of life in affected patients. Previously, a possible pathomechanism of PPE was found in doxorubicin-treated patients based on radical formation in the skin. Here, a preventive strategy using a topically applied ointment with a high radical protection factor was investigated...
June 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28631347/reducing-the-maternal-dietary-intake-of-indigestible-and-slowly-absorbed-short-chain-carbohydrates-is-associated-with-improved-infantile-colic-a-proof-of-concept-study
#8
M Iacovou, E C Mulcahy, H Truby, J S Barrett, P R Gibson, J G Muir
BACKGROUND: To investigate if a low fermentable oligo-, di- and mono-saccharides and polyols (FODMAP) diet consumed by breastfeeding mothers may be associated with reduced symptoms of infantile colic. METHODS: Exclusively breastfeeding mothers and their typically-developing healthy infants who met the Wessel Criteria for infantile colic were recruited from the community, to this single-blind, open-label, interventional study. After a 3-day qualifying period, mothers were provided a low FODMAP 7-day diet...
June 20, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28614671/gestalt-breastfeeding-helping-mothers-and-infants-optimize-positional-stability-and-intraoral-breast-tissue-volume-for-effective-pain-free-milk-transfer
#9
Pamela Douglas, Renee Keogh
In the past decade, biological nurturing and activation of maternal and infant instincts after birth have constituted a major advance in clinical breastfeeding support. Yet, physiologic breastfeeding initiation is not enough to ensure ongoing pain-free and effective breastfeeding for many pairs. Current interventions, including "hands-off" mammalian approaches, do not improve breastfeeding outcomes, including in randomized controlled trials. Back-arching, difficulty latching or staying on the breast, and fussing at the breast are common signs of infant positional instability during breastfeeding...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28610532/get-dressed-and-get-well
#10
Lorna Young
[Figure: see text] I read your #endPJparalysis news analysis (31 May) with wonder and anger. I have worked in rehabilitation nursing for more than 20 years from strokes to surgical to amputation. We always strive to get patients dressed, to aid recovery, promote independence, encourage exercise and to help the patient regain their individuality. I am shocked that the acute sector is making such a fuss about something they should have been doing all along.
June 14, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28554786/is-sensory-processing-an-issue-for-infants-with-colic
#11
Tracy Harb, Nadine Frederiksen, Rebecca J Hill
OBJECTIVES: To determine the association between sensory functioning, sleep, cry/fuss, and feeding behaviors of infants with colic younger than 4 months of age. METHODS: Dunn's Infant/Toddler Sensory Profile™ and a modified Barr Baby Day Diary(©) were used to assess 44 breastfed infants with colic under four months of age. Colic was defined according to Wessel's criteria. RESULTS: Thirty-four of the 44 infants with colic (77%) scored as atypical for sensory processing...
August 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28535011/tumor-growth-limited-to-subcutaneous-site-vs-tumor-growth-in-pulmonary-site-exhibit-differential-effects-on-systemic-immunities
#12
Junko Masuda, Eiji Takayama, Warren Strober, Ayano Satoh, Yuji Morimoto, Yasuko Honjo, Tatsuo Ichinohe, Shin-Ichi Tokuno, Toshiaki Ishizuka, Takahiro Nakata, Akifumi Mizutani, Naoki Umemura, Atsushi Kitani, Ivan J Fuss, Tsukasa Shigehiro, Harumi Kawaki, Masako Mizuno-Kamiya, Nobuo Kondoh, Masaharu Seno
To evaluate systemic immunity associated with tumor growth limited to a subcutaneous site versus growth proceeding at multiple tumor sites, we established syngeneic mouse subcutaneous and pulmonary tumor models by local subcutaneous and intravenous injection of colon carcinoma CT26 cells. We found that splenic myeloid-derived suppressor cell (MDSC) levels were significantly increased in the subcutaneous tumor model but not in the pulmonary tumor model. Furthermore, both CD4+ and CD8+ T cells as well as CD4+ Foxp3+ T cells were significantly decreased in the subcutaneous tumor model and were largely unchanged in the pulmonary tumor model...
May 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28534670/a-long-preoperative-duration-of-symptoms-is-associated-with-worse-functional-outcomes-after-1-stage-arthroscopic-treatment-of-rotator-cuff-tears-with-shoulder-stiffness
#13
Yuzhou Chen, Shiyi Chen, Yang Qiao, Yunshen Ge, Hong Li, Jiwu Chen, Yinghui Hua, Yunxia Li
BACKGROUND: Rotator cuff tears with shoulder stiffness remain a difficult issue. Despite the reported satisfactory results of 1-stage surgery, little information is available regarding the factors that affect clinical outcomes. Purpose/Hypothesis: To evaluate the 1-stage arthroscopic treatment of rotator cuff tears with shoulder stiffness and to present the influence of duration of symptoms (DOS) on postoperative functional outcomes. The hypothesis was that a long preoperative DOS is related to worse functional outcomes...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28531170/potential-hominin-affinities-of-graecopithecus-from-the-late-miocene-of-europe
#14
Jochen Fuss, Nikolai Spassov, David R Begun, Madelaine Böhme
The split of our own clade from the Panini is undocumented in the fossil record. To fill this gap we investigated the dentognathic morphology of Graecopithecus freybergi from Pyrgos Vassilissis (Greece) and cf. Graecopithecus sp. from Azmaka (Bulgaria), using new μCT and 3D reconstructions of the two known specimens. Pyrgos Vassilissis and Azmaka are currently dated to the early Messinian at 7.175 Ma and 7.24 Ma. Mainly based on its external preservation and the previously vague dating, Graecopithecus is often referred to as nomen dubium...
2017: PloS One
https://www.readbyqxmd.com/read/28530713/bach2-immunodeficiency-illustrates-an-association-between-super-enhancers-and-haploinsufficiency
#15
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Michael J Lenardo, John J O'Shea, Nichola Cooper, Arian D J Laurence
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). Single-nucleotide variants in the BACH2 locus are associated with several autoimmune diseases, but BACH2 mutations that cause Mendelian monogenic primary immunodeficiency have not previously been identified. Here we describe a syndrome of BACH2-related immunodeficiency and autoimmunity (BRIDA) that results from BACH2 haploinsufficiency...
July 2017: Nature Immunology
https://www.readbyqxmd.com/read/28528902/x-cells-are-globally-distributed-genetically-divergent-fish-parasites-related-to-perkinsids-and-dinoflagellates
#16
Mark A Freeman, Janina Fuss, Árni Kristmundsson, Marit F M Bjorbækmo, Jean-François Mangot, Javier Del Campo, Patrick J Keeling, Kamran Shalchian-Tabrizi, David Bass
"X-cells" have long been associated with tumor-like formations (xenomas) in marine fish, including many of commercial interest. The name was first used to refer to the large polygonal cells that were found in epidermal xenomas from flatfish from the Pacific Northwest [1]. Similar looking cells from pseudobranchial xenomas had previously been reported from cod in the Atlantic [2] and Pacific Oceans [3]. X-cell pathologies have been reported from five teleost orders: Pleuronectiformes (flatfish), Perciformes (perch-like fish), Gadiformes (cods), Siluriformes (catfish), and Salmoniformes (salmonids)...
June 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28451749/functional-characterization-of-the-pinoresinol-lariciresinol-reductase-2-gene-reveals-its-roles-in-yatein-biosynthesis-and-flax-defense-response
#17
Cyrielle Corbin, Samantha Drouet, Ivan Mateljak, Lucija Markulin, Cédric Decourtil, Sullivan Renouard, Tatiana Lopez, Joël Doussot, Frédéric Lamblin, Daniel Auguin, Eric Lainé, Elisabeth Fuss, Christophe Hano
This study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol-lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside (SDG) in seeds and yatein in aerial parts, in the flax plant (Linum usitatissimum L.) from which two PLR enzymes of opposite enantioselectivity have been isolated...
April 27, 2017: Planta
https://www.readbyqxmd.com/read/28443832/protective-buffering-capacity-of-restorative-dental-materials-in-vitro
#18
Markus Fuss, Michael J Wicht, Thomas Attin, Sonja H M Derman, Michael J Noack
PURPOSE: To investigate the buffering capacity of restorative materials during a simulated carious and intrinsic erosive attack. MATERIALS AND METHODS: Cavities with a volume of 130 μl were milled (Cerec MC XL) out of blocks of Ceram X Mono (CM), Quixfil (QX), Filtek Supreme (FS), Apa Fill 3 (AF), an experimental dual-curing composite containing a bioactive glass (EX), Dyract eXtra (DY), Beautifil (BE), Equia Fil (EQ), Telio CAD (TL) (negative control), TheraCal (TC; positive control), and extracted teeth (ED)...
April 25, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28427725/association-of-mild-leg-length-discrepancy-and-degenerative-changes-in-the-hip-joint-and-lumbar-spine
#19
Kelvin J Murray, Tom Molyneux, Michael R Le Grande, Aurora Castro Mendez, Franz K Fuss, Michael F Azari
OBJECTIVE: The purpose of this study was to evaluate the correlation between mild leg length discrepancy (LLD) and degenerative joint disease (DJD) or osteoarthritis. METHODS: We evaluated standard postural lumbopelvic radiographs from 255 adults (121 women and 134 men) who had presented with spinal pain for chiropractic care. Symmetry of femoral head diameters was used to exclude magnification errors. Pearson's partial correlation was used to control for age and derive effect sizes for LLD on DJD in the hip and lower lumbar motion segments...
June 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28385295/systematic-review-and-meta-analysis-fussing-and-crying-durations-and-prevalence-of-colic-in-infants
#20
Dieter Wolke, Ayten Bilgin, Muthanna Samara
OBJECTIVE: To determine the mean duration of fussing and crying and prevalence of colic using modified Wessel criteria in infants in the first 3 months of life. STUDY DESIGN: A systematic literature search was performed using the databases Medline, PsycINFO, and Embase. The major outcome measure was mean total fuss/cry duration during 24 hours at ages 1-2 weeks (11 samples), 3-4 weeks (6 samples), 5-6 weeks (28 samples), 8-9 weeks (9 samples), and 10-12 weeks (12 samples)...
June 2017: Journal of Pediatrics
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