keyword
https://read.qxmd.com/read/38340147/effect-of-continuous-hypertonic-saline-infusion-on-clinical-outcomes-in-patients-with-traumatic-brain-injury
#21
JOURNAL ARTICLE
Chi Peng, Lijie Chi, Mengjie Chen, Liwei Peng, Fan Yang, Liangjing Shao, Lulong Bo, Zhichao Jin
Osmotic therapy has been recognized as an important treatment option for patients with traumatic brain injury (TBI). Nevertheless, the effect of hypertonic saline (HTS) remains unknown, as findings are primarily based on a large database. This study aimed to elucidate the effect of HTS on the clinical outcomes of patients with TBI admitted to the intensive care unit (ICU). We retrospectively identified patients with moderate-to-severe TBI from two public databases: Medical Information Mart for Intensive Care (MIMIC)-IV and eICU Collaborative Research Database (eICU-CRD)...
February 10, 2024: Neurosurgical Review
https://read.qxmd.com/read/38328187/high-ionic-strength-vector-formulations-enhance-gene-transfer-to-airway-epithelia
#22
Ashley L Cooney, Laura Marquez Loza, Kenan Najdawi, Christian M Brommel, Paul B McCray, Patrick L Sinn
UNLABELLED: A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient ransduction of airway epithelia to achieve therapeutic correction. Hypertonic saline (HTS) is frequently administered to people with CF to enhance mucus clearance. HTS transiently disrupts epithelial cell tight unctions, but its ability to improve gene transfer has not been investigated. Here we asked if increasing the concentration of NaCl enhances the transduction efficiency of three gene therapy vectors: adenovirus, AAV, and lentiviral vectors...
January 23, 2024: bioRxiv
https://read.qxmd.com/read/38327392/use-of-a-novel-buffered-hypertonic-saline-solution-for-fluid-replacement-and-resuscitation-during-spinal-surgery-in-adolescents
#23
JOURNAL ARTICLE
Maria Lysandrou, Julie Rice-Weimer, Sibelle Aurelie Yemele Kitio, Islam Elmitwalli, Allen Kadado, Walter Samora, Marco Corridore, Joseph D Tobias
BACKGROUND: During major orthopedic procedures, such as posterior spinal fusion (PSF), isotonic fluids, colloids, starches, or gelatins are commonly used to replace the preoperative fluid deficit and provide ongoing fluid resuscitation. Given recent concerns regarding the potential adverse physiologic effects of albumin solutions, we have modified our intraoperative practice to include the use of a novel 2% buffered hypertonic saline solution during major orthopedic procedures. We present our preliminary clinical experience with this novel fluid for intraoperative resuscitation and its impact on limiting the use of 5% albumin...
January 2024: Journal of Clinical Medicine Research
https://read.qxmd.com/read/38320016/hyponatremia-treatment-guidelines-have-they-gone-too-far
#24
EDITORIAL
Juan C Ayus, Michael L Moritz
Hyponatremia is a common electrolyte abnormality affecting hospitalized patients.1 It is an independent predictor for mortality and is associated with increased length of hospital stay and higher costs. The most serious potential complication is hyponatremic encephalopathy, a medical emergency that can result in death or irreversible brain injury if inadequately treated.2 Hypertonic saline is a safe and effective means of correcting hyponatremia.2-4 A rare yet serious complication from excessive correction of chronic hyponatremia is the development of cerebral demyelination...
April 2023: NEJM Evid
https://read.qxmd.com/read/38316255/diabetes-insipidus-vasopressin-deficiency%C3%A2
#25
REVIEW
Fanny Chasseloup, Antoine Tabarin, Philippe Chanson
Diabetes insipidus is a disorder characterized by hypo-osmotic polyuria secondary to abnormal synthesis, regulation, or renal action of antidiuretic hormone. Recently, an expert group, with the support of patient associations, proposed that diabetes insipidus be renamed to avoid confusion with diabetes mellitus. The most common form of diabetes insipidus is secondary to a dysfunction in the neurohypophysis (central diabetes insipidus) and would be therefore termed 'vasopressin deficiency'. The rarer form, which is linked to renal vasopressin resistance (nephrogenic diabetes insipidus), would then be named 'vasopressin resistance'...
February 3, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38307525/comparison-of-mechanical-insufflation-exsufflation-and-hypertonic-saline-with-hyaluronic-acid-with-conventional-open-catheter-suctioning-in-intubated-patients
#26
JOURNAL ARTICLE
Miguel Sánchez-García, Manuel Álvarez-González, Sara Domingo-Marín, Ángela Del Pino-Ramírez, Fernando Martínez-Sagasti, Paloma González-Arenas, Carlos Cardenal-Sánchez, Elena Velasco-López, Antonio Núñez-Reiz
BACKGROUND: Open respiratory secretion suctioning with a catheter causes pain and injuries to the tracheobronchial mucosa in intubated patients. Mechanical insufflation-exsufflation (MI-E) aims at dragging secretions proximally non-invasively by generating a high peak expiratory airflow. Nebulized hypertonic saline with hyaluronic acid (HS-HA) facilitates suctioning by hydration. We assessed the safety and tolerance of a single session of airway clearance with MI-E and HS-HA in critically ill intubated patients...
February 2, 2024: Respiratory Care
https://read.qxmd.com/read/38284348/effects-of-anatolian-propolis-and-hypertonic-saline-combination-nasal-spray-on-allergic-rhinitis-symptoms-a-prospective-multicenter-study
#27
JOURNAL ARTICLE
Cemal Cingi, Nuray Bayar Muluk, İbrahim Çukurova, Rıza Dündar, Ustün Osma, Cengiz Bal, Alaattin Zirek, Ali Budak, Ali Seyed Resuli, Asif Selimoğlu, Aslı Elif Tanuğur Samancı, Ayşe Karaoğullarından, Begüm Yılmaz, Bengi Arslan, Bilal Sizer, Celalettin Cihan, Çiğdem Fırat Koca, Deniz Avcı, Doğukan Aydenizöz, Ethem Ünver, Elvin Alaskarov, Emrah Gülmez, Fatih Gündoğan, Gözde Günay, Hasan Çetiner, Hilal Güngör, İsmail Salcan, Mahmut Emre Gündoğan, Makbule Özlem Akbay, Mehmet Akdağ, Mehmet Erkan Kaplama, Mehmet Yaşar, Mehtap Koparal, Murat Kar, Mustafa Altıntaş, Mümtaz Taner Torun, Nazım Bozan, Neslihan Sarı, Nihat Susaman, Nurten Küçük, Osman Erdoğan, Osman Gül, Özlem Sancaklı, Pınar Kundi, Rezzan Okyay Budak, Sait Karaman, Soner Taşar, Songül Demir, Şeyda Belli, Tarık Yağcı, Taylan Bilici, Turgut Çelik, Yavuz Sultan Selim Yıldırım, Ali Timucin Atayoglu, Reşat Kubilay Irkan, Duygu Zorlu, Demet Can
Objectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks...
January 29, 2024: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38179706/surgical-correction-of-congenital-megaprepuce-a-pilot-study
#28
JOURNAL ARTICLE
Jia You, Hai-Tao Chen, Shuang Li
OBJECTIVE: Congenital megaprepuce (CMP) is a rare penile deformity that usually requires surgical correction. This study was performed to examine the efficacy of the modified Sugita procedure for repairing CMP in pediatric patients. METHODS: We retrospectively analyzed the clinical data of pediatric patients with CMP treated by a surgeon using the modified Sugita procedure in our hospital from January 2019 to April 2021. RESULTS: Twenty patients were enrolled, and their median age at surgery was 70...
January 2024: Journal of International Medical Research
https://read.qxmd.com/read/38164825/paediatric-perspectives-in-the-diagnosis-of-polyuria-polydipsia-syndrome
#29
REVIEW
Tony Huynh, Dana Signal, Mirjam Christ-Crain
The elucidation of the underlying cause of polyuria-polydipsia syndrome (PPS) is a challenging-especially in the differentiation of partial defects of arginine vasopressin (AVP) secretion or action from primary polydipsia. The water deprivation test has been utilized for many decades, and its application in the paediatric population has been applied using parameters predominantly established in adult cohorts. In more recent times, the development of automated commercial assays for copeptin, a surrogate marker for AVP, has represented a significant advancement in the diagnostic approach to PPS...
January 2, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38153868/the-cost-of-simplifying-treatments-for-cystic-fibrosis-implications-of-the-simplify-trial
#30
JOURNAL ARTICLE
Laura S Gold, Ryan N Hansen, Nicole Mayer-Hamblett, David P Nichols, Alex H Gifford, Margaret Kloster, Christopher H Goss, Larry Kessler
BACKGROUND: Dornase alfa and hypertonic saline are mucoactive therapies that can improve respiratory symptoms in people with cystic fibrosis (CF). A recent randomized control trial showed that participants with well-preserved pulmonary function taking elexacaftor + tezacaftor + ivacaftor (ETI) who discontinued dornase alfa or hypertonic saline for 6 weeks had no clinically meaningful decline in lung function. This may prompt discussions with care providers regarding ongoing use of these medications...
January 2024: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/38149132/a-rare-case-of-unprovoked-deep-cerebral-venous-sinus-thrombosis-with-associated-petechial-hemorrhage
#31
Abhinav K Rao, Ian Whitaker, Theshali Anthony, Nick Shaheen, Aidan Lum Kong
A 73-year-old male with hyperlipidemia and prior squamous cell carcinoma presented with a new-onset generalized tonic-clonic seizure and left-sided weakness. He had a progressively worsening cervical and occipital headache for nine days and was initially evaluated with an unremarkable CT head. The patient arrived at the emergency department with a left gaze deviation, prompting a "Code Neuro." CT angiography (CTA) detected a large dural sinus thrombosis, which was confirmed with a CT venogram and brain MRI...
November 2023: Curēus
https://read.qxmd.com/read/38115600/trigeminal-sensitization-in-a-closed-head-model-for-mild-traumatic-brain-injury
#32
JOURNAL ARTICLE
Akimasa Tashiro, David A Bereiter, Hiroyuki Ohta, Satoko Kawauchi, Shunichi Sato, Yuji Morimoto
Mild traumatic brain injury (mTBI) is often accompanied by neurological and ocular symptoms that involve trigeminal nerve pathways. Laser-induced shock wave (LISW) was applied to the skull of male rats as a model for mTBI, while behavioral and neural recording methods were used to assess trigeminal function. The LISW caused greater eye wiping behavior to ocular instillation of hypertonic saline (Sham = 4.83 ± 0.65 wipes/5 min, LISW = 12.71 ± 1...
January 5, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38111626/expert-group-recommendation-on-inhaled-mucoactive-drugs-in-pediatric-respiratory-diseases-an-indian-perspective
#33
REVIEW
Meenu Singh, Sneha Varkki, Ilin Kinimi, Rashmi R Das, Jagdish Prasad Goyal, Mushtaq Bhat, Rajeshwar Dayal, Pawan Kalyan, Jitender Gairolla, Indu Khosla
BACKGROUND: Currently, there are no guidelines or consensus statements about the usage of inhaled mucoactive drugs in pediatric respiratory disease conditions from an Indian perspective. OBJECTIVE: To develop a practical consensus document to help pediatricians in clinical decision-making when choosing an appropriate mucoactive drug for the management of specific respiratory disease conditions. METHODS: A committee of nine experts with significant experience in pediatric respiratory disease conditions and a microbiological expert constituted the panel...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38094455/retracted-nursing-progress-of-hypertonic-saline-inhalation-in-the-treatment-of-infantile-bronchitis-based-on-image-enhancement
#34
Computational And Mathematical Methods In Medicine
[This retracts the article DOI: 10.1155/2022/5092969.].
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/38087160/new-insights-on-diagnosis-and-treatment-of-avp-deficiency
#35
REVIEW
Julie Refardt, Cihan Atila, Mirjam Christ-Crain
Arginine vasopressin deficiency (AVP-D) is one of the main entities of the polyuria-polydipsia syndrome. Its correct diagnosis and differentiation from the other two causes - AVP resistance and primary polydipsia - is crucial as this determines the further management of these patients.Over the last years, several new diagnostic tests using copeptin, the stable surrogate marker of AVP, have been introduced. Among them, hypertonic saline stimulated copeptin was confirmed to reliably and safely improve the diagnostic accuracy to diagnose AVP-D...
December 13, 2023: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38082215/effect-of-pre-infusion-of-hypertonic-saline-on-postoperative-delirium-in-geriatric-patients-undergoing-shoulder-arthroscopy-a-randomized-controlled-trial
#36
RANDOMIZED CONTROLLED TRIAL
Fang Xu, Yanan Li, Xupeng Wang, Ran Sun, Zilei Zheng, Qi Zhang, Mingyang Gao, Wei Tao, Juan Zhao, Qiujun Wang
BACKGROUND: Neuroinflammation may be a potential mechanism of postoperative delirium (POD) in geriatric patients, and hypertonic saline (HS) has immunomodulatory properties. The purpose of this study was to investigate whether HS could reduce the incidence of POD in elderly patients and its effect on neutrophil activation and inflammatory cytokine expression. METHODS: We studied the effect of pre-infusion of 4 mL/kg 3% hypertonic saline vs. 4 mL/kg 0.9% normal saline on POD in patients undergoing shoulder arthroscopy in a prospective, randomized, double-blind, controlled trial...
December 11, 2023: BMC Anesthesiology
https://read.qxmd.com/read/38077701/chemical-meningitis-and-syndrome-of-inappropriate-antidiuretic-hormone-release-siadh-a-rare-presentation-of-pituitary-adenoma-apoplexy
#37
JOURNAL ARTICLE
Nicolas Sandakly, Georgio El Koubayati, Abir Ayoub, Claude Ghorra, Fady G Haddad
UNLABELLED: Pituitary apoplexy is an uncommon condition typically resulting from a sudden haemorrhage within a pituitary adenoma. This bleed can present clinically with a wide array of signs and symptoms. This report documents the case of a 62-year-old male who presented to the Lebanese Hospital Geitaoui University Medical Center with signs and symptoms of meningeal irritation. He was initially thought to have meningitis, and was started on antibiotics; he was then found to have pituitary adenoma apoplexy that was complicated by syndrome of inappropriate antidiuretic hormone release (SIADH)...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38036955/volume-replacement-in-the-resuscitation-of-trauma-patients-with-acute-hemorrhage-an-umbrella-review
#38
JOURNAL ARTICLE
Silvia Gianola, Greta Castellini, Annalisa Biffi, Gloria Porcu, Antonello Napoletano, Daniela Coclite, Daniela D'Angelo, Marco Di Nitto, Alice Josephine Fauci, Ornella Punzo, Primiano Iannone, Osvaldo Chiara
BACKGROUND: The use of intravenous fluid therapy in patients with major trauma in prehospital settings is still controversial. We conducted an umbrella review to evaluate which is the best volume expansion in the resuscitation of a hemorrhagic shock to support the development of major trauma guideline recommendations. METHODS: We searched PubMed, Embase, and CENTRAL up to September 2022 for systematic reviews (SRs) investigating the use of volume expansion fluid on mortality and/or survival...
November 30, 2023: International Journal of Emergency Medicine
https://read.qxmd.com/read/38019099/assessing-safety-of-discontinuing-hypertonic-saline-in-those-with-lower-fev1-after-elexacaftor-tezacaftor-ivacaftor
#39
JOURNAL ARTICLE
David Nichols, Alex Gifford, Renee Russell, Katherine Odem-Davis, Julia Young, Rodolfo Amaro-Galvez, Joanne Billings, Zubin Mukadam, Nicole Mayer-Hamblett
No abstract text is available yet for this article.
November 29, 2023: Annals of the American Thoracic Society
https://read.qxmd.com/read/38011984/nebulised-3-hypertonic-saline-versus-0-9-saline-for-treating-patients-hospitalised-with-acute-bronchiolitis-protocol-for-a-randomised-double-blind-multicentre-trial
#40
JOURNAL ARTICLE
Sara Szupieńko, Aleksandra Buczek, Henryk Szymański
INTRODUCTION: Bronchiolitis is an acute viral infection of the lower respiratory tract. It is most commonly caused by respiratory syncytial virus. Being a common reason for hospitalisation, it affects 13-17% of all hospitalised children younger than 2 years. Only supportive therapy, including suctioning nasal secretions, water-electrolyte balance maintenance and oxygen supplementation when needed, is recommended. However, non-evidence-based diagnostic and therapeutic approaches, including the use of inhaled bronchodilators, nebulised epinephrine, and nebulised and systemic steroids, are common...
November 27, 2023: BMJ Open
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