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https://www.readbyqxmd.com/read/29911580/modulation-of-the-muscle-and-nerve-compound-muscle-action-potential-by-evoked-pain
#1
L Duez, E Qerama, T S Jensen, A Fuglsang-Frederiksen
Background and aims To our knowledge there are no studies that have examined the effects of the experimental pain on muscle fibre excitability as measured by the amplitudes of the potentials evoked by direct muscle stimulation (DMS) in a muscle at rest. We hypothesized that evoked pain can modulate the muscle compound action potential (CMAP) obtained by DMS possibly due to changes in muscle fibre excitability. Methods Pain was evoked by intramuscular infusion of hypertonic saline in 50 men. Ten control subjects were infused with isotonic saline...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911577/the-dynamics-of-the-pain-system-is-intact-in-patients-with-knee-osteoarthritis-an-exploratory-experimental-study
#2
Tanja Schjødt Jørgensen, Marius Henriksen, Sara Rosager, Louise Klokker, Karen Ellegaard, Bente Danneskiold-Samsøe, Henning Bliddal, Thomas Graven-Nielsen
Background and aims Despite the high prevalence of knee osteoarthritis (OA) it remains one of the most frequent knee disorders without a cure. Pain and disability are prominent clinical features of knee OA. Knee OA pain is typically localized but can also be referred to the thigh or lower leg. Widespread hyperalgesia has been found in knee OA patients. In addition, patients with hyperalgesia in the OA knee joint show increased pain summation scores upon repetitive stimulation of the OA knee suggesting the involvement of facilitated central mechanisms in knee OA...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909244/change-in-viral-bronchiolitis-management-in-hospitals-in-the-uk-after-the-publication-of-nice-guideline
#3
Rachael Barr, Elliott J Carande, Andrew J Pollard, Simon B Drysdale
BACKGROUND: Viral bronchiolitis is one of the most common causes of hospitalisation in young infants. It has previously been shown that many United Kingdom (UK) hospital Trusts were not compliant with many aspects of the National Institute for Health and Care Excellence (NICE) bronchiolitis guideline prior to its publication. OBJECTIVES: This study aimed to investigate changes in the management of bronchiolitis by hospital Trusts between 2015 (before NICE guideline publication) and 2017, after publication...
June 12, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29905883/hypertonic-saline-or-mannitol-for-treating-elevated-intracranial-pressure-in-traumatic-brain-injury-a-meta-analysis-of-randomized-controlled-trials
#4
Jiajie Gu, Haoping Huang, Yuejun Huang, Haitao Sun, Hongwu Xu
Hyperosmolar therapy is regarded as the mainstay for treatment of elevated intracranial pressure (ICP) in traumatic brain injury (TBI). This still has been disputed as application of hypertonic saline (HS) or mannitol for treating patients with severe TBI. Thus, this meta-analysis was performed to further compare the advantages and disadvantages of mannitol with HS for treating elevated ICP after TBI. We conducted a systematic search on PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wan Fang Data, VIP Data, SinoMed, and China National Knowledge Infrastructure (CNKI) databases...
June 15, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29903912/molecular-principles-for-heparin-oligosaccharide-based-inhibition-of-neutrophil-elastase-in-cystic-fibrosis
#5
Apparao B Kummarapurugu, Daniel K Afosah, Nehru Viji Sankaranarayanan, Rahaman Navaz Gangji, Shuo Zheng, Thomas P Kennedy, Bruce K Rubin, Judith A Voynow, Umesh R Desai
Cystic fibrosis (CF)1 is a multi-factorial disease in which dysfunction of protease-antiprotease balance plays a key role. The current CF therapy relies on dornase alfa, low dose macrolide antibiotics, hypertonic saline and antibiotics, and does not address the high neutrophil elastase (NE) activity observed in the lung and sputum of CF patients. Our hypothesis is that variants of heparin, which potently inhibit NE but are not anticoagulant, would help restore the protease-antiprotease balance in CF. To realize this concept, we studied molecular principles governing the effectiveness of different heparins, especially 2-O,3-O-desulfated heparin (ODSH), in the presence of sputum components and therapeutic agents...
June 14, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29893029/impact-of-hypertonic-saline-on-hospitalization-rate-in-infants-with-acute-bronchiolitis-a-meta-analysis
#6
Linjie Zhang, Carlos B Gunther, Ozeia S Franco, Terry P Klassen
AIM: This meta-analysis aimed to assess the efficacy of nebulized hypertonic saline (HS) on the rate of hospitalization in infants with acute bronchiolitis in the Emergency Department (ED) setting. METHOD: We searched PubMed, Virtual Health Library-BVS and Cochrane CENTRAL from inception until January 31, 2018. We selected randomized trials that compared nebulized HS with normal saline (NS) or standard care in children up to 24 months of age with acute bronchiolitis in the ED setting...
June 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29878856/impact-of-hypertonic-saline-solutions-on-sputum-expectoration-and-their-safety-profile-in-patients-with-bronchiectasis-a-randomized-crossover-trial
#7
Beatriz Herrero-Cortina, Victoria Alcaraz, Jordi Vilaró, Antoni Torres, Eva Polverino
BACKGROUND: The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sputum quantity with better safety profile than HS alone in patients with bronchiectasis. METHODS: In this double-blind randomized crossover trial, three solutions (7% HS; 0.1% HA +7%HS; and 0.9% isotonic saline, IS) were compared in outpatients with bronchiectasis and chronic sputum expectoration...
June 7, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29864998/experimental-neck-muscle-pain-increase-pressure-pain-threshold-over-cervical-facet-joints
#8
Ning Qu, René Lindstrøm, Rogerio Pessoto Hirata, Thomas Graven-Nielsen
Aims Evaluate pressure pain threshold (PPT) over cervical facet joints before and after injection of experimental pain in the trapezius and multifidus muscles. Methods Fourteen healthy subjects (6 women) received randomized ultrasound-guided injections of hypertonic saline (5.8%), in the right multifidus muscle medial to C4/C5 facet joint and in the right trapezius muscle at the midpoint between C7 spinous process and acromion. The saline-induced pain intensity was assessed on a VAS scale. Before and during saline-induced pain PPTs were assessed by pressure algometry bilaterally over C2/C3 and C5/C6 facet joints...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29864997/acute-muscle-pain-alters-corticomotor-output-of-the-affected-muscle-stronger-than-a-synergistic-ipsilateral-muscle
#9
Dennis Boye Larsen, Thomas Graven-Nielsen, Rogerio Pessoto Hirata, Shellie A Boudreau
Aims Muscle pain affects corticomotor areas representing the affected muscle, by changing the size of representation and reduces the corticospinal output as assessed by transcranial magnetic stimulation (TMS). Less work has been done to understand how pain in one muscle group may affect synergistic ipsilateral muscles distal to the pain. This study aimed to explore the effects of acute extensor carpi radialis (ECR) muscle pain on TMS motor-evoked potentials (MEPs) of the ECR and the first dorsal interosseus (FDI) muscle, which are known to strongly overlap within the corticomotor area...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29857893/females-have-stronger-neurogenic-response-than-males-after-non-specific-nasal-challenge-in-patients-with-seasonal-allergic-rhinitis
#10
Dejan Tomljenovic, Tomislav Baudoin, Zeljka Bukovec Megla, Goran Geber, Glenis Scadding, Livije Kalogjera
Epidemiological studies show female predominance in the prevalence of non- allergic rhinitis (NAR) and local allergic rhinitis (LAR). Experimental studies show female patients with allergic rhinitis (AR) demonstrate higher levels of sensitivity to irritants and airway hyperresponsiveness than males. Bronchial asthma shows female predominance in post-puberty patients, and gender interaction with severe asthma endotypes. Fibromyalgia, chronic fatigue syndrome, migraine and chronic cough, syndromes, which are commonly related to neurokinin substance P (SP) in the literature, also show strong female predominance...
July 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29850939/superabsorbent-polymer-microspheres-prepared-with-hypertonic-saline-to-reduce-microsphere-expansion
#11
Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Kohei Morita, Chiho Obayashi, Shinich Hori, Masaaki Kaneko, Ai Kijima, Kimihiko Kichikawa
PURPOSE: To analyze size changes of superabsorbent polymer (SAP) microspheres with the reduced expansion technique, and to evaluate pharmacological advantages of transarterial chemoembolization using cisplatin-loaded SAP microspheres with the reduced expansion technique. MATERIALS AND METHODS: In an in vitro study, diluted contrast materials containing different concentrations of sodium ions were examined to expand SAP microspheres and determined the reduced expansion technique...
May 30, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29849568/differential-corticomotor-excitability-responses-to-hypertonic-saline-induced-muscle-pain-in-forearm-and-hand-muscles
#12
Dennis B Larsen, Thomas Graven-Nielsen, Rogerio P Hirata, Shellie A Boudreau
Experimental muscle pain inhibits corticomotor excitability (CE) of upper limb muscles. It is unknown if this inhibition affects overlapping muscle representations within the primary motor cortex to the same degree. This study explored CE changes of the first dorsal interosseus (FDI) and extensor carpi radialis (ECR) muscles in response to muscle pain. Participants ( n = 13) attended two sessions (≥48 hours in-between). Hypertonic saline was injected in the ECR (session one) or the FDI (session two) muscle...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29848210/activation-of-rat-masticatory-muscle-afferent-fibres-by-acidic-ph
#13
Parisa Gazerani, Brian Edwin Cairns
Previous research findings have suggested an important role for acid sensing ion channels (ASICs) in muscle pain mechanisms. This study was conducted to determine if masticatory muscle afferent fibres express ASICs, if there are sex differences in this expression, and to compare the effects of low pH and hypertonic saline on afferent fibres that innervate the masticatory muscle in vivo. Immunohistochemistry methods were applied to examine the expression of ASICs in trigeminal ganglion neurons, while in vivo electrophysiology techniques were employed to examine changes in masticatory muscle afferent fibre excitability...
May 30, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29793596/hypertonic-sodium-lactate-reverses-brain-oxygenation-and-metabolism-dysfunction-after-traumatic-brain-injury
#14
A Millet, A Cuisinier, P Bouzat, C Batandier, B Lemasson, V Stupar, K Pernet-Gallay, T Crespy, E L Barbier, J F Payen
BACKGROUND: The mechanisms by which hypertonic sodium lactate (HSL) solution act in injured brain are unclear. We investigated the effects of HSL on brain metabolism, oxygenation, and perfusion in a rodent model of diffuse traumatic brain injury (TBI). METHODS: Thirty minutes after trauma, anaesthetised adult rats were randomly assigned to receive a 3 h infusion of either a saline solution (TBI-saline group) or HSL (TBI-HSL group). The sham-saline and sham-HSL groups received no insult...
June 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29793320/orofacial-antinociceptive-effect-of-mimosa-tenuiflora-willd-poiret
#15
Francisco Ernani A Magalhães, Francisco Lucas A Batista, Ohanna F Serpa, Luiz F Wemmenson G Moura, Maria da Conceição L Lima, Ana Raquel A da Silva, Maria Izabel F Guedes, Sacha Aubrey A R Santos, Breytiner A de Oliveira, Andressa B Nogueira, Talita M Barbosa, Dayse Karine R Holanda, Marina B M V Damasceno, José de Maria A de Melo, Lana Karine V Barroso, Adriana R Campos
Mimosa tenuiflora (Willd.) Poiret, popularly known in Brazil as "jurema-preta" is widely used against bronchitis, fever, headache and inflammation. Its antioxidant, anti-inflammatory and antinociceptive potential has already been reported. To assess the orofacial antinociceptive effect of M. tenuiflora, ethanolic extracts of M. tenuiflora (leaves, twigs, barks and roots) were submitted to in vitro tests of antioxidant activity. The extract with the highest antioxidant potential was partitioned and subjected to preliminary chemical prospecting, GC-MS, measurement of phenolic content and cytotoxicity tests of the fraction with the highest antioxidant activity...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29774747/hypertonic-saline-versus-isotonic-saline-nasal-irrigation-systematic-review-and-meta-analysis
#16
Dichapong Kanjanawasee, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29773609/cured-bronchi-extending-the-use-of-nebulised-hypertonic-saline-outside-of-cystic-fibrosis
#17
EDITORIAL
Clémence Martin, Lucile Regard, Pierre-Régis Burgel
No abstract text is available yet for this article.
May 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29772761/high-concentrations-of-sodium-chloride-improve-microbicidal-activity-of-ibuprofen-against-common-cystic-fibrosis-pathogens
#18
Adrián J Muñoz, Roxana V Alasino, Ariel G Garro, Valeria Heredia, Néstor H García, David C Cremonezzi, Dante M Beltramo
Ibuprofen (IBU-H), a widely used anti-inflammatory, also shows a marked antimicrobial effect against several bacterial species, including those involved in cystic fibrosis such as Pseudomona aeruginosa , methicillin resistant Staphylococcus aureus and Burkholderia cepacia complex. Additionally, our results show significant synergy between water soluble Na-ibuprofen (IBU-Na) and ionic strength. Salt concentrations above 0.5 M modify the zeta potential promoting the action of Na-IBU; thus, with 1 M sodium chloride, IBU-Na is ten times more efficient than in the absence of ionic strength, and the minimum effective contact time is reduced from hours to minutes...
May 17, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29766326/the-change-in-management-of-bronchiolitis-in-the-intensive-care-unit-between-2000-and-2015
#19
Minna Mecklin, Paula Heikkilä, Matti Korppi
This case-control study evaluated interventions for bronchiolitis in relation to time in the pediatric intensive care unit (PICU) during a 16-year surveillance period. Together, 105 infants aged < 12 months were treated for bronchiolitis in the PICU, and for them, we selected 210 controls admitted for bronchiolitis closest to cases. We collected data on treatments in the PICU, at the ward and in the emergency department for three periods: years 2000-2005, 2006-2010, and 2011-2015. Median hospital length of stay for PICU patients were 7 days (interquartile range 5-12), 5 days (4-8) and 8 days (4-12...
May 15, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29764447/efficacy-of-intra-articular-hypertonic-dextrose-prolotherapy-versus-normal-saline-for-knee-osteoarthritis-a-protocol-for-a-triple-blinded-randomized-controlled-trial
#20
Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung, Samuel Yeung Shan Wong
BACKGROUND: Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Dextrose Prolotherapy (DPT) is an evidence-based injection-based therapy for chronic musculoskeletal conditions including KOA. The standard "whole joint" injection method includes intra-articular injection and multiple extra-articular injections at soft tissue bony attachments...
May 15, 2018: BMC Complementary and Alternative Medicine
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