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Cruciferous vegetables

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https://www.readbyqxmd.com/read/28304346/consumption-of-fruit-or-fiber-fruit-decreases-the-risk-of-cardiovascular-disease-in-a-mediterranean-young-cohort
#1
Pilar Buil-Cosiales, Miguel Angel Martinez-Gonzalez, Miguel Ruiz-Canela, Javier Díez-Espino, Ana García-Arellano, Estefania Toledo
Fiber and fiber-rich foods have been inversely associated with cardiovascular disease (CVD), but the evidence is scarce in young and Mediterranean cohorts. We used Cox regression models to assess the association between quintiles of total fiber and fiber from different sources, and the risk of CVD adjusted for the principal confounding factors in a Mediterranean cohort of young adults, the SUN (Seguimiento Universidad de Navarra, Follow-up) cohort. After a median follow-up of 10.3 years, we observed 112 cases of CVD among 17,007 participants (61% female, mean age 38 years)...
March 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28302225/-advances-in-research-of-antitumor-mechanisms-of-isothiocyanates
#2
Huimin Wang, Ke Xu
Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28292742/fatty-acid-synthesis-intermediates-represent-novel-noninvasive-biomarkers-of-prostate-cancer-chemoprevention-by-phenethyl-isothiocyanate
#3
Krishna B Singh, Shivendra V Singh
Increased de novo synthesis of fatty acids is a distinctive feature of prostate cancer, which continues to be a leading cause of cancer-related deaths among American men. Therefore, inhibition of de novo fatty acid synthesis represents an attractive strategy for chemoprevention of prostate cancer. We have shown previously that dietary feeding of phenethyl isothiocyanate (PEITC), a phytochemical derived from edible cruciferous vegetables such as watercress, inhibits incidence and burden of poorly-differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model...
March 14, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28290614/establishment-and-application-of-molecular-id-in-the-main-inbred-lines-of-chinese-cabbage
#4
X X Zhang, X B Tang, Y Liu, Y W Zhang
Chinese cabbage is an important cruciferous vegetable in China. The differences in the morphology and other characteristics of the different varieties of Chinese cabbage are generally caused by their different genes. Using the simple sequence repeat (SSR) DNA molecular markers is an effective way to identify different genotypes. The identification of a genetic relationship is a key point in the breeding process, and it plays an important role in guiding parent selection and breeding of high-yield varieties...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28274282/flight-performance-of-macdunnoughia-crassisigna-lepidoptera-noctuidae
#5
X-W Fu, H Chang, L-M He, S-Y Zhao, K-M Wu
Macdunnoughia crassisigna Warren (Lepidoptera: Noctuidae) is a highly destructive herbivore that poses a serious risk to cotton, maize, soybean, and cruciferous vegetables in East Asia. Examining the effects of various biotic and abiotic factors on the flight performance of M. crassisigna is crucial for a better understanding of its trans-regional migration. In this study, the flight activity of M. crassisignai moths of different ages, under different temperatures and relative humidity (RH) levels, was evaluated by tethering individuals to computerized flight mills for a 24-h trial period...
March 9, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28272911/effect-of-cruciferous-vegetable-intake-on-oxidative-stress-biomarkers-differences-by-breast-cancer-status
#6
Michael D Wirth, E Angela Murphy, Thomas G Hurley, James R Hébert
This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus...
March 8, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28249935/an-adolescent-and-early-adulthood-dietary-pattern-associated-with-inflammation-and-the-incidence-of-breast-cancer
#7
Holly R Harris, Walter C Willett, Rita L Vaidya, Karin B Michels
Adolescence is a highly susceptible period for mammary carcinogenesis, but few prospective studies have examined the role of adolescent diet in breast cancer risk. Reduced rank regression has previously been used to identify a dietary pattern associated with markers of inflammation (C-reactive protein, IL6, and TNFα receptor 2). We investigated whether an adolescent and early adulthood inflammatory dietary pattern was associated with breast cancer among 45,204 women in the Nurses' Health Study II using reduced rank regression...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28228764/de-novo-transcriptome-assembly-of-chinese-kale-and-global-expression-analysis-of-genes-involved-in-glucosinolate-metabolism-in-multiple-tissues
#8
Shuanghua Wu, Jianjun Lei, Guoju Chen, Hancai Chen, Bihao Cao, Changming Chen
Chinese kale, a vegetable of the cruciferous family, is a popular crop in southern China and Southeast Asia due to its high glucosinolate content and nutritional qualities. However, there is little research on the molecular genetics and genes involved in glucosinolate metabolism and its regulation in Chinese kale. In this study, we sequenced and characterized the transcriptomes and expression profiles of genes expressed in 11 tissues of Chinese kale. A total of 216 million 150-bp clean reads were generated using RNA-sequencing technology...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28208739/a-guide-to-the-variability-of-flavonoids-in-brassica-oleracea
#9
REVIEW
Vera Mageney, Susanne Neugart, Dirk C Albach
Flavonoids represent a typical secondary metabolite class present in cruciferous vegetables. Their potential as natural antioxidants has raised considerable scientific interest. Impacts on the human body after food consumption as well as their effect as pharmaceutical supplements are therefore under investigation. Their numerous physiological functions make them a promising tool for breeding purposes. General methods for flavonoid analysis are well established, though new compounds are still being identified...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28176652/mechanisms-for-inhibition-of-colon-cancer-cells-by-sulforaphane-through-epigenetic-modulation-of-microrna-21-and-human-telomerase-reverse-transcriptase-htert-down-regulation
#10
Samantha L Martin, Rishabh Kala, Trygve O Tollefsbol
Epigenetic modulations such as histone modifications are becoming increasingly valued for their ability to modify genes without altering the DNA sequence. Many bioactive compounds have been shown to alter genetic and epigenetic profiles in various forms of 6 cancers. Of the many dietary phytochemicals, sulforaphane (SFN), found in cruciferous vegetables such as kale, cabbage and broccoli sprouts, has been present as one of the most potent (histone deacetylase) HDAC inhibitors to date. Recently, it has been 9 identified that HDAC inhibitors may play a vital role in regulating microRNAs (miRNAs) in many human cancers...
February 5, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28132970/allyl-nitrile-toxicity-and-health-effects
#11
Hideji Tanii
OBJECTIVES: Allyl nitrile (3-butenenitrile) occurs naturally in the environment, in particular, in cruciferous vegetables, indicating a possible daily intake of the compound. There is no report on actual health effects of allyl nitrile in humans, although it is possible that individuals in the environment are at a risk of exposure to allyl nitrile. However, little is known about its quantitative assessment for the environment and bioactivity in the body. This study provides a review of previous accumulated studies on allyl nitrile...
January 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28132875/the-impact-of-cruciferous-vegetable-isothiocyanates-on-histone-acetylation-and-histone-phosphorylation-in-bladder-cancer
#12
Besma Abbaoui, Kelly H Telu, Christopher R Lucas, Jennifer M Thomas-Ahner, Steven J Schwartz, Steven K Clinton, Michael A Freitas, Amir Mortazavi
Cruciferous vegetable intake is associated with reduced risk of bladder cancer, yet mechanisms remain unclear. Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20μM, 48h treatment), and in bladder cancer xenografts (59±3% ECN inhibition). Individual HDACs inhibited by SFN and ECN include HDACs 1, 2, 4 and 6. Interestingly, global acetylation status of histones H3 or H4 remain unaltered...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28132764/3h-1-2-dithiole-3-thione-as-a-novel-therapeutic-agent-for-the-treatment-of-ischemic-stroke-through-nrf2-defense-pathway
#13
Ping-Chang Kuo, I-Chen Yu, Barbara A Scofield, Dennis A Brown, Eric T Curfman, Hallel C Paraiso, Fen-Lei Chang, Jui-Hung Yen
Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species produced in brain tissue induce oxidative stress and inflammatory responses. D3T, the simplest compound of the cyclic, sulfur-containing dithiolethiones, is found in cruciferous vegetables, and has been reported to induce anti-oxidant genes and glutathione biosynthesis through activation of Nrf2. In addition to anti-oxidant activity, D3T was also reported to possess anti-inflammatory effects...
January 26, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28112178/benzyl-isothiocyanate-induces-protective-autophagy-in-human-lung-cancer-cells-through-an-endoplasmic-reticulum-stress-mediated-mechanism
#14
Qi-Cheng Zhang, Zhen-Hua Pan, Bo-Ning Liu, Zhao-Wei Meng, Xiang Wu, Qing-Hua Zhou, Ke Xu
Isothiocyanates, such as allyl isothiocya¬nate (AITC), benzyl isothiocyanate (BITC), phenethyl isothio¬cyanate (PEITC) and sulforaphane (SFN), are natural compounds abundant in cruciferous vegetables, which have substantial chemopreventive activities against various human malignancies. However, the mechanisms underlying the inhibition of tumor cell growth by isothiocyanates are not fully understood. Since autophagy has dual functions in cancer, in the present study we investigated the effects of BITC on autophagy induction in human lung cancer cells in vitro and in vivo...
January 23, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28079155/dietary-phytochemical-peitc-restricts-tumor-development-via-modulation-of-epigenetic-writers-and-erasers
#15
Jung Eun Park, Yang Sun, Sai Kiang Lim, James P Tam, Matthijs Dekker, Hong Chen, Siu Kwan Sze
Dietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown. We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restriction. Colon cancer cells treated with low-dose PEITC for >1 month exhibited stable alterations in expression profile of epigenetic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28059653/sulforaphane-suppresses-the-growth-of-glioblastoma-cells-glioblastoma-stem-cell-like-spheroids-and-tumor-xenografts-through-multiple-cell-signaling-pathways
#16
Khadijeh Bijangi-Vishehsaraei, M Reza Saadatzadeh, Haiyan Wang, Angie Nguyen, Malgorzata M Kamocka, Wenjing Cai, Aaron A Cohen-Gadol, Stacey L Halum, Jann N Sarkaria, Karen E Pollok, Ahmad R Safa
OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resistance in glioblastoma (GBM). Moreover, another complexity related to GBM treatment is the concept that GBM development and recurrence may arise from the expression of GBM stem cells (GSCs). Therefore, the use of a multifaceted approach or multitargeted agents that affect specific tumor cell characteristics will likely be necessary to successfully eradicate GBM. The objective of this study was to investigate the usefulness of sulforaphane (SFN)-a constituent of cruciferous vegetables with a multitargeted effect-as a therapeutic agent for GBM...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28054242/anti-nociceptive-and-anti-inflammatory-actions-of-sulforaphane-in-chronic-constriction-injury-induced-neuropathic-pain-mice
#17
Cheng Wang, Congpin Wang
Neuropathic pain is still considered as incurable disease as current therapies are not ideal in terms of efficacy and tolerability. It is imperative to search for novel drugs to obtain better treatments. Sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables, exhibits therapeutic effects on inflammation-related diseases. Since inflammation plays an important role in regulating chronic pain, in the present study, we investigated anti-nociceptive effects of SFN and its underlying mechanisms in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI)...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27997560/activation-of-human-salivary-aldehyde-dehydrogenase-by-sulforaphane-mechanism-and-significance
#18
Md Fazle Alam, Amaj Ahmed Laskar, Lubna Maryam, Hina Younus
Cruciferous vegetables contain the bio-active compound sulforaphane (SF) which has been reported to protect individuals against various diseases by a number of mechanisms, including activation of the phase II detoxification enzymes. In this study, we show that the extracts of five cruciferous vegetables that we commonly consume and SF activate human salivary aldehyde dehydrogenase (hsALDH), which is a very important detoxifying enzyme in the mouth. Maximum activation was observed at 1 μg/ml of cabbage extract with 2...
2016: PloS One
https://www.readbyqxmd.com/read/27979631/indole-3-carbinol-i3c-analogues-are-potent-small-molecule-inhibitors-of-nedd4-1-ubiquitin-ligase-activity-that-disrupt-proliferation-of-human-melanoma-cells
#19
Jeanne G Quirit, Sergey N Lavrenov, Kevin Poindexter, Janice Xu, Christine Kyauk, Kathleen A Durkin, Ida Aronchik, Thomas Tomasiak, Yaroslav A Solomatin, Maria N Preobrazhenskaya, Gary L Firestone
The HECT domain-containing E3 ubiquitin ligase NEDD4-1 (Neural precursor cell Expressed Developmentally Down regulated gene 4-1) is frequently overexpressed in human cancers and displays oncogenic-like properties through the ubiquitin-dependent regulation of multiple protein substrates. However, little is known about small molecule enzymatic inhibitors of HECT domain-containing ubiquitin ligases. We now demonstrate that indole-3-carbinol (I3C), a natural anti-cancer phytochemical derived from cruciferous vegetables such as cabbage and broccoli, represents a new chemical scaffold of small molecule enzymatic inhibitors of NEDD4-1...
December 12, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27919950/development-of-a-novel-experimental-in-vitro-model-of-isothiocyanate-induced-apoptosis-in-human-malignant-melanoma-cells
#20
Theodora Mantso, Aristeidis P Sfakianos, Aithne Atkinson, Ioannis Anestopoulos, Melina Mitsiogianni, Sotirios Botaitis, Sebachedin Perente, Constantinos Simopoulos, Stavros Vasileiadis, Rodrigo Franco, Aglaia Pappa, Mihalis I Panayiotidis
BACKGROUND: Isothiocyanates are constituents of cruciferous vegetables which have been associated with reduced cancer risk partially through their ability to induce apoptosis in malignant cells including melanoma. MATERIALS AND METHODS: We have utilized human malignant melanoma (A375), epidermoid carcinoma (A431) and immortalized keratinocyte (HaCaT) cells exposed to various isothiocyanates, under different experimental conditions. RESULTS: An experimental in vitro model utilizing low isothiocyanate concentrations (0...
2016: Anticancer Research
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