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Cruciferous vegetables

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https://www.readbyqxmd.com/read/28911742/inheritance-and-stability-of-mevinphos-resistance-in-plutella-xylostella-l-with-special-reference-to-mutations-of-acetylcholinesterase-1
#1
Chia-Li Lin, Shih-Chia Yeh, Hai-Tung Feng, Shu-Mei Dai
Diamondback moth (Plutella xylostella L.) causes enormous damage on cruciferous vegetables and can rapidly develop resistance to all kinds of insecticides. To effectively manage the insecticide resistance of P. xylostella, an understanding of its inheritance and stability is essential. Here we investigated the phenotypic and genotypic basis of mevinphos resistance by crossing two genetically pure lines of P. xylostella, an SHggt wild-type strain and an SHMTCN resistant strain carrying 892T/T, 971C/C, and 1156T/G (TCN) mutations of the acetylcholinesterase 1 gene (Pxace1)...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28881649/identification-of-deubiquitinase-targets-of-isothiocyanates-using-silac-assisted-quantitative-mass-spectrometry
#2
Ann P Lawson, Daniel W Bak, D Alexander Shannon, Marcus J C Long, Tushara Vijaykumar, Runhan Yu, Farid El Oualid, Eranthie Weerapana, Lizbeth Hedstrom
Cruciferous vegetables such as broccoli and kale have well documented chemopreventative and anticancer effects that are attributed to the presence of isothiocyanates (ITCs). ITCs modulate the levels of many oncogenic proteins, but the molecular mechanisms of ITC action are not understood. We previously reported that phenethyl isothiocyanate (PEITC) inhibits two deubiquitinases (DUBs), USP9x and UCH37. DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurodegeneration, and inflammation...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28873525/development-of-validated-high-temperature-reverse-phase-uhplc-pda-analytical-method-for-simultaneous-analysis-of-five-natural-isothiocyanates-in-cruciferous-vegetables
#3
Robin, Rohit Arora, Saroj Arora, Adarsh Pal Vig
In the present study reverse-phase UHPLC-PDA technique was developed at 60°C for simultaneous quantification of allyl, 3-butenyl, 4-(methylthio)butyl, benzyl and phenethyl isothiocyanates. The validation parameter showed a very good linearity, with a correlation coefficient of 1.00 for all detected standard analytes. Also, high precision and accuracy were observed with lowest obtained values of 1.39% and 99.1%, respectively. Different varieties of three plants, viz. Brassica rapa var. rapa L., Raphanus sativus L...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28869285/microbiota-a-mediator-to-transform-glucosinolate-precursors-in-cruciferous-vegetables-to-the-active-isothiocyanates
#4
REVIEW
Sicong Tian, Peng Lei, Xiaodong Liu, Xiaohong Zhang, Yujuan Shan
Isothiocyanates (ITCs), such as sulforaphane (SFN), exhibit powerful biological functions in fighting cancers, and cardiovascular and neurodegenerative diseases. They normally exist as glucosinolates (GLSs) in cruciferous vegetables, which are not themselves bioactive until they are degraded by myrosinase to form the ITCs. Myrosinase co-exists in the same plants but is normally kept apart from GLSs in different apparatus. A key point is that myrosinase is temperature-sensitive and can be inactivated upon exposure to temperatures over 60°C, as typically occurs during cooking...
September 4, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28864908/antitumor-activity-and-expression-profiles-of-genes-induced-by-sulforaphane-in-human-melanoma-cells
#5
Paola Arcidiacono, Francesco Ragonese, Anna Stabile, Alessandra Pistilli, Ekaterina Kuligina, Mario Rende, Ugo Bottoni, Stefano Calvieri, Andrea Crisanti, Roberta Spaccapelo
PURPOSE: Human melanoma is a highly aggressive incurable cancer due to intrinsic cellular resistance to apoptosis, reprogramming, proliferation and survival during tumour progression. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, plays a role in carcinogenesis in many cancer types. However, the cytotoxic molecular mechanisms and gene expression profiles promoted by SFN in human melanoma remain unknown. METHODS: Three different cell lines were used: two human melanoma A375 and 501MEL and human epidermal melanocytes (HEMa)...
September 1, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28854561/sulforaphane-suppresses-prmt5-mep50-function-in-epidermal-squamous-cell-carcinoma-leading-to-reduced-tumor-formation
#6
Kamalika Saha, Matthew L Fisher, Gautam Adhikary, Daniel Grun, Richard L Eckert
Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival. We have studied the role of PRMT5 and MEP50 in epidermal squamous cell carcinoma. We show that knockdown of PRMT5 or MEP50 results in reduced H4R3me2s formation, and reduced cell proliferation, invasion, migration and tumor formation. We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration...
August 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28838245/the-nutritive-value-of-organic-and-conventional-white-cabbage-brassica-oleracea-l-var-capitata-and-anti-apoptotic-activity-in-gastric-adenocarcinoma-cells-of-sauerkraut-juice-produced-therof
#7
Ewelina Hallmann, Renata Kazimierczak, Krystian Marszałek, Nadzieja Drela, Ewelina Kiernozek, Peeter Toomik, Darja Matt, Anne Luik, Ewa Rembiałkowska
White cabbage is one of the most important vegetables grown both in Poland and worldwide. Cabbage contains considerable amounts of bioactive compounds such as glucosinolates, vitamin C, carotenoids, and polyphenols. Some experiments indicate that vegetables from organic production contain more bioactive compounds than those from conventional production, however, only a few studies have been conducted on cruciferous plants. The presented study has proved that organic fresh cabbage, compared to the conventional one, contained significantly less total flavonoids in both years of experiments (3...
September 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28830206/sulforaphane-reduces-hmgb1-mediated-septic-responses-and-improves-survival-rate-in-septic-mice
#8
In-Chul Lee, Dae Yong Kim, Jong-Sup Bae
Sulforaphane (SFN), a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of severe sepsis or septic shock. In this study, we examined the effects of SFN on HMGB1-mediated septic responses and survival rate in a mouse sepsis model. The anti-inflammatory activities of SFN were monitored based on its effects on lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-mediated release of HMGB1...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28825609/the-role-of-micrornas-in-the-chemopreventive-activity-of-sulforaphane-from-cruciferous-vegetables
#9
REVIEW
Christopher Dacosta, Yongping Bao
Colorectal cancer is an increasingly significant cause of mortality whose risk is linked to diet and inversely correlated with cruciferous vegetable consumption. This is likely to be partly attributable to the isothiocyanates derived from eating these vegetables, such as sulforaphane, which is extensively characterised for cytoprotective and tumour-suppressing activities. However, its bioactivities are likely to extend in complexity beyond those currently known; further insight into these bioactivities could aid the development of sulforaphane-based chemopreventive or chemotherapeutic strategies...
August 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28821405/benzyl-isothiocyanate-ameliorates-acetaldehyde-induced-cytotoxicity-by-enhancing-aldehyde-dehydrogenase-activity-in-murine-hepatoma-hepa1c1c7-cells
#10
Yujia Liu, Momoko Yamanaka, Naomi Abe-Kanoh, Xiaoyang Liu, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata, Yoshimasa Nakamura
In the present study, we assessed benzyl isothiocyanate (BITC), an organosulfur compound from cruciferous vegetables, as a potential inducer of aldehyde dehydrogenase (ALDH) activity using murine hepatoma Hepa1c1c7 cells. BITC was shown to enhance not only the total ALDH activity, but also the ALDH activity of the cytosolic/microsomal and mitochondrial fraction. BITC also significantly increased the gene and protein expression of ALDH1A1, ALDH2 and ALDH3A1 in a concentration-dependent manner. Simultaneously, the gene expression of phase 2 drug-metabolizing enzymes, such as NAD(P)H: quinone oxidoreductase 1 and heme oxygenase-1, was increased by the BITC treatment...
August 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28812344/in-vitro-bile-acid-binding-capacities-of-red-leaf-lettuce-and-cruciferous-vegetables
#11
Isabelle F Yang, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
In the present study, we tested the bile acid binding capacity of red leaf lettuce, red cabbage, red kale, green kale, and Brussels sprouts through in vitro digestion process by simulating mouth, gastric, and intestinal digestion using six bile acids at physiological pH. Green and red kale exhibited significantly higher (86.5 ± 2.9 and 89.7 ± 0.9%, respectively) bile acid binding capacity compared to the other samples. Further, three different compositions of bile acids were tested to understand the effect on different health conditions...
August 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28802295/food-acceptance-and-anthropometry-in-relation-to-6-n-propylthiouracil-sensitivity-in-japanese-college-women
#12
Ayako Nagai, Masaru Kubota, Kanako Morinaga, Yukie Higashiyama
BACKGROUND AND OBJECTIVES: Differences in anthropometry and food acceptance among tasters and non-tasters of 6-n-propylthiouracil has been well studied in Western countries. However, reports on this issue from Asian countries are still limited. METHODS AND STUDY DESIGN: Healthy Japanese students attending Nara Women's University (n=153) were recruited and classified into 3 groups based on taste sensitivity to a 0.32 mM 6-npropylthiouracil solution as scored on a labeled magnitude scale...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28764905/comparison-of-short-and-long-term-exposure-effects-of-cruciferous-and-apiaceous-vegetables-on-carcinogen-metabolizing-enzymes-in-wistar-rats
#13
Jae Kyeom Kim, Noemia Strapazzon, Cynthia M Gallaher, Dwight R Stoll, William Thomas, Daniel D Gallaher, Sabrina P Trudo
Cruciferous and apiaceous vegetables may be chemopreventive due to their ability to modulate carcinogen-metabolizing enzymes but whether the effects on such enzymes are sustained over time is unknown. To examine the short- and long-term effects of the vegetables, rats were fed one of four diets for 7, 30, or 60 d: AIN-93G, CRU (21% cruciferous vegetables-fresh broccoli, green cabbage, watercress), API (9% apiaceous vegetables - fresh parsnips, celery), or API + CRU (10.5% CRU + 4.5% API). Although CRU increased activity and protein expression of cytochrome P450 (CYP) 1A1 and CYP1A2 after 7 d, only activity was sustained after 30 and 60 d...
July 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28747562/isothiocyanates-suppress-the-invasion-and-metastasis-of-tumors-by-targeting-fak-mmp-9-activity
#14
Yun-Jeong Jeong, Hyun-Ji Cho, Fung-Lung Chung, Xiantao Wang, Hyang-Sook Hoe, Kwan-Kyu Park, Cheorl-Ho Kim, Hyeun-Wook Chang, Sang-Rae Lee, Young-Chae Chang
Isothiocyanates, which are present as glucosinolate precursors in cruciferous vegetables, have strong activity against various cancers. Here, we compared the anti-metastatic effects of isothiocyanates (benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and sulforaphane (SFN)) by examining how they regulate MMP-9 expression. Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines. By contrast, N-methyl phenethylamine, a PEITC analog without an isothiocyanate functional group, had no effect...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28735362/the-role-of-sulforaphane-in-cancer-chemoprevention-and-health-benefits-a-mini-review
#15
Reza Bayat Mokhtari, Narges Baluch, Tina S Homayouni, Evgeniya Morgatskaya, Sushil Kumar, Parandis Kazemi, Herman Yeger
Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell. Different chemopreventative approaches have been sought to interfere with initiation and control malignant progression. Here we present research on dietary compounds with evidence of cancer prevention activity that highlights the potential beneficial effect of a diet rich in cruciferous vegetables...
July 23, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28730528/sulforaphane-promotes-mitochondrial-protection-in-sh-sy5y-cells-exposed-to-hydrogen-peroxide-by-an-nrf2-dependent-mechanism
#16
Marcos Roberto de Oliveira, Flávia de Bittencourt Brasil, Cristina Ribas Fürstenau
Sulforaphane (SFN; C6H11NOS2) is an isothiocyanate found in cruciferous vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti-tumor, and anti-inflammatory activities in different cell types. However, it was not previously demonstrated whether and how this natural compound would exert mitochondrial protection experimentally. Therefore, we investigated here the effects of a pretreatment (for 30 min) with SFN at 5 μM on mitochondria obtained from human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide (H2O2) at 300 μM for 24 h...
July 20, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28710147/dietary-guidelines-for-breast-cancer-patients-a-critical-review
#17
REVIEW
Ana Teresa Limon-Miro, Veronica Lopez-Teros, Humberto Astiazaran-Garcia
Current dietary guidelines for breast cancer patients (BCPs) fail to address adequate dietary intakes of macro- and micronutrients that may improve patients' nutritional status. This review includes information from the PubMed and Biomed Central databases over the last 15 y concerning dietary guidelines for BCPs and the potential impact of a personalized, nutrient-specific diet on patients' nutritional status during and after antineoplastic treatment. Results indicated that BCPs should receive a nutritional assessment immediately after diagnosis...
July 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28700650/sulforaphane-enhances-irradiation-effects-in-terms-of-perturbed-cell-cycle-progression-and-increased-dna-damage-in-pancreatic-cancer-cells
#18
Patrick Naumann, Jakob Liermann, Franco Fortunato, Thomas E Schmid, Klaus-Josef Weber, Jürgen Debus, Stephanie E Combs
BACKGROUND: Sulforaphane (SFN), an herbal isothiocyanate enriched in cruciferous vegetables like broccoli and cauliflower, has gained popularity for its antitumor effects in cell lines such as pancreatic cancer. Antiproliferative as well as radiosensitizing properties were reported for head and neck cancer but little is known about its effects in pancreatic cancer cells in combination with irradiation (RT). METHODS: In four established pancreatic cancer cell lines we investigated clonogenic survival, analyzed cell cycle distribution and compared DNA damage via flow cytometry and western blot after treatment with SFN and RT...
2017: PloS One
https://www.readbyqxmd.com/read/28698459/dietary-natural-products-for-prevention-and-treatment-of-breast-cancer
#19
REVIEW
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang, Hua-Bin Li
Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28677733/sulforaphane-inhibits-the-interferon-%C3%AE-induced-expression-of-mig-ip-10-and-i-tac-in-ins%C3%A2-1-pancreatic-%C3%AE-cells-through-the-downregulation-of-irf-1-stat-1-and-pkb
#20
Yu-Kyoung Park, Mahesh Ramalingam, Shin Kim, Byeong-Churl Jang, Jong Wook Park
Sulforaphane (SFN) is a dietary isothiocyanate abundantly available in cruciferous vegetables and has been shown to possess anti-inflammatory and immunomodulatory activities. Chemokines are important mediators of inflammation and immune responses due to their ability to recruit and activate macrophages and leukocytes. To date, little is known about the SFN-mediated regulation of chemokine expression in pancreatic β-cells. In this study, we investigated the inhibitory effects and mechanisms of SFN on the interferon-γ (IFN-γ)-induced expression of a subset of chemokines, including monokine induced by IFN-γ (MIG), IFN-inducible protein of 10 kDa (IP-10) and IFN-inducible T‑cell alpha chemoattractant (I-TAC), in INS‑1 cells, a rat pancreatic β-cell line...
September 2017: International Journal of Molecular Medicine
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