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Cruciferous vegetables

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https://www.readbyqxmd.com/read/29113871/oxidative-stress-and-dietary-phytochemicals-role-in-cancer-chemoprevention-and-treatment
#1
Shireen Chikara, Lokesh Dalasanur Nagaprashantha, Jyotsana Singhal, David Horne, Sanjay Awasthi, Sharad S Singhal
Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing oxidative stress-induced DNA damage. In addition, they modulate several oxidative stress-mediated signaling pathways through their anti-oxidant effects, and ultimately protect cells from undergoing molecular changes that trigger carcinogenesis...
November 4, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29111554/sulforaphane-protects-mle-12-lung-epithelial-cells-against-oxidative-damage-caused-by-ambient-air-particulate-matter
#2
An-Shi Wang, Yan Xu, Zhuang-Wei Zhang, Bei-Bei Lu, Xuan Yin, An-Jun Yao, Li-Yuan Han, Zu-Quan Zou, Zhen Li, Xiao-Hong Zhang
Ambient air particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) can cause pulmonary injury. Oxidative stress is thought to be an important mechanism of PM2.5-mediated toxicity. Sulforaphane (SFN), a compound derived from cruciferous vegetables, is a well-known potent antioxidant; however, its protective effect on lung epithelial cells exposed to PM2.5 is unclear. The results showed that SFN pre-treatment markedly inhibited PM2.5-induced apoptosis of the type II alveolar epithelial cell line MLE-12 by elevating glutathione S-transferase levels and decreasing reactive oxygen species...
November 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29100952/effect-of-isothiocyanates-bitc-and-peitc-on-stress-protein-accumulation-protein-aggregation-and-aggresome-like-structure-formation-in-xenopus-a6-kidney-epithelial-cells
#3
Imran Khamis, John J Heikkila
Numerous studies have elucidated the health benefits of organosulfur compounds, known as isothiocyanates (ITCs), derived from cruciferous vegetables. As electrophiles, ITCs have the ability to directly bind and modify thiol-containing compounds such as glutathione and cellular protein, including tubulin. While the biochemical effects of ITCs have been well characterized, less information is available regarding their effects on the accumulation of stress-inducible heme oxygenase-1 (HO-1), heat shock proteins (HSPs) and the possible formation of aggregated protein due to thiol modification...
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29073716/antitumor-activity-of-lepidium-latifolium-and-identification-of-the-epithionitrile-1-cyano-2-3-epithiopropane-as-its-major-active-component
#4
María Conde-Rioll, Consuelo Gajate, José J Fernández, Janny A Villa-Pulgarin, José G Napolitano, Manuel Norte, Faustino Mollinedo
Consumption of Brassica (Cruciferae) vegetables is associated with a reduced risk of cancer, but identification of the active components and insights into the underlying molecular events are scarce. Here we found that an extract of Lepidium latifolium, a cruciferous plant native to southern Europe, Mediterranean countries and Asia, showed in vitro cytotoxic activity, inducing caspase-dependent apoptosis, in a variety of human tumor cells, and the plant juice showed in vivo antitumor activity in a HT-29 human colon cancer xenograft mouse model...
October 26, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29069573/sulforaphane-restores-acetyl-histone-h3-binding-to-bcl-2-promoter-and-prevents-apoptosis-in-ethanol-exposed-neural-crest-cells-and-mouse-embryos
#5
Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Lu Cai, Xiaoyang Wu, Shao-Yu Chen
Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables. SFN's cytoprotective properties have been demonstrated in several models associated with a variety of disorders. Our recent studies have shown that SFN protects against ethanol-induced oxidative stress and apoptosis in neural crest cells (NCCs), an ethanol-sensitive cell population implicated in Fetal Alcohol Spectrum Disorders (FASD). This study is designed to test the hypothesis that SFN can prevent ethanol-induced apoptosis in NCCs by inhibiting HDAC and increasing histone acetylation at the Bcl-2 promoter...
October 22, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29066442/cruciferous-and-allium-vegetable-intakes-are-inversely-associated-with-15-year-atherosclerotic-vascular-disease-deaths-in-older-adult-women
#6
Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis, Amanda Devine, Kun Zhu, Wai H Lim, Richard J Woodman, Lawrence J Beilin, Richard L Prince, Jonathan M Hodgson
BACKGROUND: Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality. METHODS AND RESULTS: The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998)...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29039568/3-3-%C3%A2-diindolylmethane-attenuates-cardiomyocyte-hypoxia-by-modulating-autophagy-in-h9c2-cells
#7
Kai Liang, Wen-Hao Qian, Jing Zong
Autophagy is activated in the ischemic heart and is a process that is essential for survival, differentiation, development and homeostasis. 3,3'‑Diindolylmethane (DIM) is a natural product of the acid‑catalyzed condensation of indole‑3‑carbinol in cruciferous vegetables. Numerous studies have suggested that DIM has various pharmacological effects, including antioxidant, antitumor, anti‑angiogenic and anti‑apoptotic properties. However, the function of DIM on hypoxia‑induced cardiac injury remains to be elucidated...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29029393/intermittent-treatment-with-farnesyltransferase-inhibitor-and-sulforaphane-improves-cellular-homeostasis-in-hutchinson-gilford-progeria-fibroblasts
#8
Diana Gabriel, Dinah Dorith Shafry, Leslie B Gordon, Karima Djabali
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such as hair loss, thin skin, joint stiffness, and atherosclerosis. The latter leads to heart attack or stroke that causes death at an average age of 14.6 years in children with HGPS. The typical LMNA mutation results in the production of a truncated prelamin A protein, progerin, that remains permanently farnesylated and abnormally associated with the nuclear envelope...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29017835/two-goitrogenic-1-3-oxazolidine-2-thione-derivatives-from-brassicales-taxa-challenging-identification-occurrence-and-immunomodulatory-effects
#9
Niko S Radulović, Milica M Todorovska, Dragan B Zlatković, Nikola M Stojanović, Pavle J Randjelović
1,3-Oxazolidine-2-thione derivatives are glucosinolate-related food constituents known to impart (thyreo)toxic properties to some cruciferous vegetables. In this work, 5,5-dimethyl-1,3-oxazolidine-2-thione and (-)-(R)-5-phenyl-1,3-oxazolidine-2-thione, known goitrogens, were isolated from Draba lasiocarpa Rochel (Brassicaceae) and Reseda luteola L. (Resedaceae), respectively, and were fully spectrally characterized. Subsequently, the occurrence of the two 1,3-oxazolidine-2-thiones was verified in six additional taxa out of in total 78 screened Serbian Brassicales taxa...
October 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28990541/associations-of-dietary-patterns-with-bone-mass-muscle-strength-and-balance-in-a-cohort-of-australian-middle-aged-women
#10
Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones, Tania Winzenberg
Influences of dietary patterns on musculoskeletal health are poorly understood in middle-aged women. This cross-sectional analysis from a cohort of 347 women (aged 36-57 years) aimed to examine associations between dietary patterns and musculoskeletal health outcomes in middle-aged women. Diet was measured by the Cancer Council of Victoria FFQ. Total body bone mineral content (TB BMC), femoral neck and lumbar spine bone density (dual-energy X-ray absorptiometry), lower limbs muscle strength (LMS) and balance tests (timed up and go test, step test, functional reach test (FRT) and lateral reach test) were also measured...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28969043/isothiocyanates-suppress-the-invasion-and-metastasis-of-tumors-by-targeting-fak-mmp-9-activity
#11
Yun-Jeong Jeong, Hyun-Ji Cho, Fung-Lung Chung, Xiantao Wang, Hyang-Sook Hoe, Kwan-Kyu Park, Cheorl-Ho Kim, Hyeun-Wook Chang, Sang-Rae Lee, Young-Chae Chang
Isothiocyanates, which are present as glucosinolate precursors in cruciferous vegetables, have strong activity against various cancers. Here, we compared the anti-metastatic effects of isothiocyanates (benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and sulforaphane (SFN)) by examining how they regulate MMP-9 expression. Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines. By contrast, N-methyl phenethylamine, a PEITC analog without an isothiocyanate functional group, had no effect...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968558/associations-between-oral-hygiene-habits-diet-tobacco-and-alcohol-and-risk-of-oral-cancer-a-case-control-study-from-india
#12
Bhawna Gupta, Freddie Bray, Narinder Kumar, Newell W Johnson
OBJECTIVE: This study examines the association between the incidence of oral cancer in India and oral hygiene habits, diet, chewing and smoking tobacco, and drinking alcohol. We also assessed the effects of oral hygiene habits with oral cancer risk among chewers versus never chewers. METHODS: A hospital-based case-control study was conducted in Pune, India, based on face-to-face interviews, anthropometry, and intra-oral examinations conducted for 187 oral cancer cases and 240 controls...
September 29, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28911742/inheritance-and-stability-of-mevinphos-resistance-in-plutella-xylostella-l-with-special-reference-to-mutations-of-acetylcholinesterase-1
#13
Chia-Li Lin, Shih-Chia Yeh, Hai-Tung Feng, Shu-Mei Dai
Diamondback moth (Plutella xylostella L.) causes enormous damage on cruciferous vegetables and can rapidly develop resistance to all kinds of insecticides. To effectively manage the insecticide resistance of P. xylostella, an understanding of its inheritance and stability is essential. Here we investigated the phenotypic and genotypic basis of mevinphos resistance by crossing two genetically pure lines of P. xylostella, an SHggt wild-type strain and an SHMTCN resistant strain carrying 892T/T, 971C/C, and 1156T/G (TCN) mutations of the acetylcholinesterase 1 gene (Pxace1)...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28881649/identification-of-deubiquitinase-targets-of-isothiocyanates-using-silac-assisted-quantitative-mass-spectrometry
#14
Ann P Lawson, Daniel W Bak, D Alexander Shannon, Marcus J C Long, Tushara Vijaykumar, Runhan Yu, Farid El Oualid, Eranthie Weerapana, Lizbeth Hedstrom
Cruciferous vegetables such as broccoli and kale have well documented chemopreventative and anticancer effects that are attributed to the presence of isothiocyanates (ITCs). ITCs modulate the levels of many oncogenic proteins, but the molecular mechanisms of ITC action are not understood. We previously reported that phenethyl isothiocyanate (PEITC) inhibits two deubiquitinases (DUBs), USP9x and UCH37. DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurodegeneration, and inflammation...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28873525/development-of-validated-high-temperature-reverse-phase-uhplc-pda-analytical-method-for-simultaneous-analysis-of-five-natural-isothiocyanates-in-cruciferous-vegetables
#15
Robin, Rohit Arora, Saroj Arora, Adarsh Pal Vig
In the present study reverse-phase UHPLC-PDA technique was developed at 60°C for simultaneous quantification of allyl, 3-butenyl, 4-(methylthio)butyl, benzyl and phenethyl isothiocyanates. The validation parameter showed a very good linearity, with a correlation coefficient of 1.00 for all detected standard analytes. Also, high precision and accuracy were observed with lowest obtained values of 1.39% and 99.1%, respectively. Different varieties of three plants, viz. Brassica rapa var. rapa L., Raphanus sativus L...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28869285/microbiota-a-mediator-to-transform-glucosinolate-precursors-in-cruciferous-vegetables-to-the-active-isothiocyanates
#16
REVIEW
Sicong Tian, Peng Lei, Xiaodong Liu, Xiaohong Zhang, Yujuan Shan
Isothiocyanates (ITCs), such as sulforaphane (SFN), exhibit powerful biological functions in fighting cancers, and cardiovascular and neurodegenerative diseases. They normally exist as glucosinolates (GLSs) in cruciferous vegetables, which are not themselves bioactive until they are degraded by myrosinase to form the ITCs. Myrosinase co-exists in the same plants but is normally kept apart from GLSs in different apparatus. A key point is that myrosinase is temperature-sensitive and can be inactivated upon exposure to temperatures over 60°C, as typically occurs during cooking...
September 4, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28864908/antitumor-activity-and-expression-profiles-of-genes-induced-by-sulforaphane-in-human-melanoma-cells
#17
Paola Arcidiacono, Francesco Ragonese, Anna Stabile, Alessandra Pistilli, Ekaterina Kuligina, Mario Rende, Ugo Bottoni, Stefano Calvieri, Andrea Crisanti, Roberta Spaccapelo
PURPOSE: Human melanoma is a highly aggressive incurable cancer due to intrinsic cellular resistance to apoptosis, reprogramming, proliferation and survival during tumour progression. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, plays a role in carcinogenesis in many cancer types. However, the cytotoxic molecular mechanisms and gene expression profiles promoted by SFN in human melanoma remain unknown. METHODS: Three different cell lines were used: two human melanoma A375 and 501MEL and human epidermal melanocytes (HEMa)...
September 1, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28854561/sulforaphane-suppresses-prmt5-mep50-function-in-epidermal-squamous-cell-carcinoma-leading-to-reduced-tumor-formation
#18
Kamalika Saha, Matthew L Fisher, Gautam Adhikary, Daniel Grun, Richard L Eckert
Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival. We have studied the role of PRMT5 and MEP50 in epidermal squamous cell carcinoma. We show that knockdown of PRMT5 or MEP50 results in reduced H4R3me2s formation, and reduced cell proliferation, invasion, migration and tumor formation. We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration...
August 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28838245/the-nutritive-value-of-organic-and-conventional-white-cabbage-brassica-oleracea-l-var-capitata-and-anti-apoptotic-activity-in-gastric-adenocarcinoma-cells-of-sauerkraut-juice-produced-therof
#19
COMPARATIVE STUDY
Ewelina Hallmann, Renata Kazimierczak, Krystian Marszałek, Nadzieja Drela, Ewelina Kiernozek, Peeter Toomik, Darja Matt, Anne Luik, Ewa Rembiałkowska
White cabbage is one of the most important vegetables grown both in Poland and worldwide. Cabbage contains considerable amounts of bioactive compounds such as glucosinolates, vitamin C, carotenoids, and polyphenols. Some experiments indicate that vegetables from organic production contain more bioactive compounds than those from conventional production, however, only a few studies have been conducted on cruciferous plants. The presented study has proved that organic fresh cabbage, compared to the conventional one, contained significantly less total flavonoids in both years of experiments (3...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28830206/sulforaphane-reduces-hmgb1-mediated-septic-responses-and-improves-survival-rate-in-septic-mice
#20
In-Chul Lee, Dae Yong Kim, Jong-Sup Bae
Sulforaphane (SFN), a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of severe sepsis or septic shock. In this study, we examined the effects of SFN on HMGB1-mediated septic responses and survival rate in a mouse sepsis model. The anti-inflammatory activities of SFN were monitored based on its effects on lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-mediated release of HMGB1...
2017: American Journal of Chinese Medicine
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