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Cruciferous vegetables

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https://www.readbyqxmd.com/read/29764806/temporal-efficacy-of-a-sulforaphane-based-broccoli-sprout-diet-in-prevention-of-breast-cancer-through-modulation-of-epigenetic-mechanisms
#1
Yuanyuan Li, Phillip Buckhaults, Shizhao Li, Trygve O Tollefsbol
Breast cancer is the most common cancer and the second leading cause of cancer death among women. An important risk factor for breast cancer is individual genetic background which is initially generated early in human life; for example, during the processes of embryogenesis and fetal development in utero. Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms...
May 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29751617/cardiovascular-health-benefits-of-specific-vegetable-types-a-narrative-review
#2
REVIEW
Lauren C Blekkenhorst, Marc Sim, Catherine P Bondonno, Nicola P Bondonno, Natalie C Ward, Richard L Prince, Amanda Devine, Joshua R Lewis, Jonathan M Hodgson
Adequate vegetable consumption is one of the cornerstones of a healthy diet. The recommendation to increase vegetable intake is part of most dietary guidelines. Despite widespread and long-running public health messages to increase vegetable intake, similar to other countries worldwide, less than 1 in 10 adult Australians manage to meet target advice. Dietary guidelines are predominantly based on studies linking diets high in vegetables with lower risk of chronic diseases. Identifying vegetables with the strongest health benefits and incorporating these into dietary recommendations may enhance public health initiatives around vegetable intake...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29748497/profiling-of-phenolic-compounds-and-antioxidant-activity-of-12-cruciferous-vegetables
#3
Zhifeng Li, Hui Wen Lee, Xu Liang, Dong Liang, Qi Wang, Dejian Huang, Choon Nam Ong
The phenolic profiles of 12 cruciferous vegetables (pakchoi, choysum, Chinese cabbage, kailan, Brussels sprout, cabbage, cauliflower, broccoli, rocket salad, red cherry radish, daikon radish, and watercress) were studied with UHPLC-MS/MS. Antioxidant activity and total phenolic content (TPC) were also evaluated. A total of 74 phenolic compounds were identified, including 16 hydroxycinnamic acids and derivatives, and 58 flavonoids and derivatives. The main flavonoids identified were glycosylated quercetin, kaempferol and isorhamnetin, and the main hydroxycinnamic acids were ferulic, sinapic, caffeic and p -coumaric acids...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29739681/cruciferous-vegetable-intake-and-mortality-in-middle-aged-adults-a-prospective-cohort-study
#4
Nagisa Mori, Taichi Shimazu, Hadrien Charvat, Michihiro Mutoh, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Manami Inoue, Atsushi Goto, Ribeka Takachi, Junko Ishihara, Mitsuhiko Noda, Hiroyasu Iso, Shoichiro Tsugane
BACKGROUND & AIMS: Cruciferous vegetables contain isothiocyanates, which effectively reduce inflammation and oxidative stress related to chronic diseases, inhibit the bioactivation of procarcinogens, and enhance the excretion of carcinogens. However, at present, no large cohort studies have investigated the effect of cruciferous vegetable on mortality. We aimed to examine the association between cruciferous vegetable intake and all-cause mortality, namely cancer, heart disease, cerebrovascular disease, and injuries, in a large cohort study conducted between 1990 and 1993, in Japan...
April 24, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29722480/3-3-diindolylmethane-enhances-glucose-uptake-through-activation-of-insulin-signaling-in-3t3-l1-adipocytes
#5
Kyeong-Mi Choi, Hwan-Soo Yoo
OBJECTIVE: Indole-3-carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3'-diindolylmethane (DIM) reduce body mass and serum glucose levels in high-fat-diet-induced obese mice. This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3-L1 adipocytes, as well as the mechanism involved. METHODS: 3T3-L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin...
May 3, 2018: Obesity
https://www.readbyqxmd.com/read/29714053/sulforaphane-upregulates-the-heat-shock-protein-co-chaperone-chip-and-clears-amyloid-%C3%AE-and-tau-in-a-mouse-model-of-alzheimer-s-disease
#6
Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, we investigated whether sulforaphane modulates the production of amyloid-β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD). METHODS AND RESULTS: A triple transgenic mouse model of AD (3 × Tg-AD) was used to study the effect of sulforaphane. Oral gavage of sulforaphane reduced protein levels of monomeric and polymeric forms of Aβ as well as tau and phosphorylated tau in 3 × Tg-AD mice...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710398/phenethyl-isothiocyanate-a-dual-activator-of-transcription-factors-nrf2-and-hsf1
#7
REVIEW
Sharadha Dayalan Naidu, Takafumi Suzuki, Masayuki Yamamoto, Jed W Fahey, Albena T Dinkova-Kostova
Cruciferous vegetables are rich sources of glucosinolates which are the biogenic precursor molecules of isothiocyanates (ITCs). The relationship between the consumption of cruciferous vegetables and chemoprotection has been widely documented in epidemiological studies. Phenethyl isothiocyanate (PEITC) occurs as its glucosinolate precursor gluconasturtiin in the cruciferous vegetable watercress (Nasturtium officinale). PEITC has multiple biological effects, including activation of cytoprotective pathways, such as those mediated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) and the transcription factor heat shock factor 1 (HSF1), and can cause changes in the epigenome...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29701645/effects-of-200-gy-60-co-%C3%AE-radiation-on-the-regulation-of-antioxidant-enzymes-hsp70-genes-and-serum-molecules-of-plutella-xylostella-linnaeus
#8
Xiaoxue Li, Lingyan Luo, Sengodan Karthi, Ke Zhang, Jianjun Luo, Qiongbo Hu, Qunfang Weng
The diamondback moth, Plutella xylostella (Linnaeus), is one of the notorious pests causing substantial loses to many cruciferous vegetables across the nations. The effects of 60 Co-γ radiation on physiology of P. xylostella were investigated and the results displayed that 200 Gy irradiation significantly alters the antioxidant enzyme regulation in six-day-old male pupae of P. xylostella . First, in our research, we detected Oxidase system and stress response mechanism of irradiated pupae, the results displayed that 200 Gy irradiation significantly alters the antioxidant enzyme regulation in six-day-old male pupae of P...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29693426/usual-cruciferous-vegetable-consumption-and-ovarian-cancer-a-case-control-study
#9
Hallie McManus, Kirsten B Moysich, Li Tang, Janine Joseph, Susan E McCann
Ovarian cancer is the fifth leading cause of cancer-related deaths among women, primarily due to diagnosis at late stages. Therefore, identification of modifiable risk factors for this disease is warranted. Using the Patient Epidemiology Data System (PEDS), collected from 1981 to 1998 at Roswell Park Cancer Institute, Buffalo, NY, we conducted a hospital-based, case-control analysis of self-reported cruciferous vegetable intake and ovarian cancer among 675 women with primary, incident ovarian cancer, and 1275 without cancer...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29692548/extraction-profiling-and-bioactivity-analysis-of-volatile-glucosinolates-present-in-oil-extract-of-brassica-juncea-var-raya
#10
Priyanka Bassan, Sakshi Bhushan, Tajinder Kaur, Rohit Arora, Saroj Arora, Adarsh Pal Vig
Cruciferous vegetables are rich source of glucosinolates (GSLs), which in presence of myrosinase enzyme cause hydrolytic cleavage and result in different hydrolytic products like isothiocyanates, thiocyanates, nitriles and epinitriles. The GSLs hydrolytic products are volatile compounds, which are known to exhibit bioactivities like antioxidant, fungicidal, bioherbicidal and anticancer. Among the Brassicaceae family, Brassica juncea is very well known for high content of GSLs. In the present study, the isolation of volatile oil of B...
May 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29689276/withaferin-a-and-sulforaphane-regulate-breast-cancer-cell-cycle-progression-through-epigenetic-mechanisms
#11
Kendra J Royston, Bidisha Paul, Susan Nozell, Rajani Rajbhandari, Trygve O Tollefsbol
Little is known about the effects of combinatorial dietary compounds on the regulation of epigenetic mechanisms involved in breast cancer prevention. The human diet consists of a multitude of components, and there is a need to elucidate how certain compounds interact in collaboration. Withaferin A (WA), found in the Indian winter cherry and documented as a DNA methyltransferase (DNMT) inhibitor, and sulforaphane (SFN), a well-known histone deacetylase (HDAC) inhibitor found in cruciferous vegetables, are two epigenetic modifying compounds that have only recently been studied in conjunction...
April 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29685968/impact-of-dietary-gut-microbial-metabolites-on-the-epigenome
#12
REVIEW
Clarissa Gerhauser
Within the past decade, epigenetic mechanisms and their modulation by natural products have gained increasing interest. Dietary bioactive compounds from various sources, including green tea, soya, fruit and berries, cruciferous vegetables, whole grain foods, fish and others, have been shown to target enzymes involved in epigenetic gene regulation, including DNA methyltransferases, histone acetyltransferases, deacetylases and demethylases in vitro and in cell culture. Also, many dietary agents were shown to alter miRNA expression...
June 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29666895/suppression-of-glutathione-s-transferases-potentiates-the-cytotoxic-effect-of-phenethyl-isothiocyanate-in-cholangiocarcinoma-cells
#13
Ornanong Tusskorn, Tueanjai Khunluck, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Veerapol Kukongviriyapan
Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables. Previous studies have shown that the effect of PEITC-induced cell death declines rapidly after administration. The metabolic fate of PEITC is modulated by glutathione S-transferases (GST). In this study, we investigated whether GST activity modulates PEITC-induced cytotoxicity on cholangiocarcinoma (CCA) cells. The sensitivity of KKU-M214 and KKU-100 cells to PEITC was associated with GST activity...
April 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29663679/the-role-of-cruciferous-vegetables-and-isothiocyanates-for-lung-cancer-prevention-current-status-challenges-and-future-research-directions
#14
REVIEW
Zhenzhen Zhang, Raymond Bergan, Jackilen Shannon, Christopher G Slatore, Gerd Bobe, Yumie Takata
Lung cancer remains a leading cause of cancer-related deaths in the United States. Although smoking and air pollution exposure are primary risk factors of lung cancer, diet has also been reported to contribute to lung cancer risk. Cruciferous vegetables contain many bioactive compounds that alter the detoxification process of air-borne carcinogenic compounds and, thereby, may decrease lung cancer risk. In our meta-analysis of 31 observational studies, cruciferous vegetable intake was inversely associated with lung cancer risk (summary odds ratio/relative risk = 0...
April 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29644960/glucosinolate-and-isothiocyanate-intakes-are-inversely-associated-with-breast-cancer-risk-a-case-control-study-in-china
#15
Nai-Qi Zhang, Suzanne C Ho, Xiong-Fei Mo, Fang-Yu Lin, Wu-Qing Huang, Hong Luo, Jing Huang, Cai-Xia Zhang
Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29618474/cruciferous-and-total-vegetable-intakes-are-inversely-associated-with-subclinical-atherosclerosis-in-older-adult-women
#16
Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis, Richard J Woodman, Amanda Devine, Nicola P Bondonno, Wai H Lim, Kun Zhu, Lawrence J Beilin, Peter L Thompson, Richard L Prince, Jonathan M Hodgson
BACKGROUND: Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years)...
April 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29607466/autophagy-inhibition-improves-the-chemotherapeutic-efficacy-of-cruciferous-vegetable-derived-diindolymethane-in-a-murine-prostate-cancer-xenograft-model
#17
Hossam Draz, Alexander A Goldberg, Emma S Tomlinson Guns, Ladan Fazli, Stephen Safe, J Thomas Sanderson
Prostate cancer is the second leading cause of cancer-related deaths in men in North America and there is an urgent need for development of more effective therapeutic treatments against this disease. We have recently shown that diindolylmethane (DIM) and several of its halogenated derivatives (ring-DIMs) induce death and protective autophagy in human prostate cancer cells. However, the in vivo efficacy of ring-DIMs and the use of autophagy inhibitors as adjuvant therapy have not yet been studied in vivo. The objective of this study was to determine these effects on tumor growth in nude CD-1 mice bearing bioluminescent androgen-independent PC-3 human prostate cancer cells...
April 2, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29599332/phenethyl-isothiocyanate-induces-apoptotic-cell-death-through-the-mitochondria-dependent-pathway-in-gefitinib-resistant-nci-h460-human-lung-cancer-cells-in-vitro
#18
Te-Chun Hsia, Yi-Ping Huang, Yi-Wen Jiang, Hsin-Yu Chen, Zheng-Yu Cheng, Yung-Ting Hsiao, Cheng-Yen Chen, Shu-Fen Peng, Fu-Shin Chueh, Yu-Cheng Chou, Jing-Gung Chung
BACKGROUND/AIM: Some lung cancer patients treated with gefitinib develop resistance to this drug resulting in unsatisfactory treatment outcomes. Phenethyl isothiocyanate (PEITC), present in our common cruciferous vegetables, exhibits anticancer activities in many human cancer cell lines. Currently, there is no available information on the possible modification of gefitinib resistance of lung cancer in vitro by PEITC. Thus, the effects of PEITC on gefitinib resistant lung cancer NCI-H460 cells were investigated in vitro...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29595853/phenethyl-isothiocyanate-in-combination-with-dibenzoylmethane-inhibits-the-androgen-independent-growth-of-prostate-cancer-cells
#19
Huarong Huang, Yan He, Lanyue Zhang, Hongping Xiang, Dongli Li, Wenfeng Liu, Xue-Tao Xu, Susan Goodin, Kun Zhang, Xi Zheng
Phenethyl isothiocyanate (PEITC) is a naturally occurring compound found in some cruciferous vegetables. Dibenzoylmethane (DBM) is a minor constituent of licorice. Both compounds have been shown to exert anticancer activities. In the present study, we determined the effects of PEITC and DBM alone or in combination on androgen-independent growth of human prostate cancer cells cultured in vitro and prostate VCaP xenograft tumors in severe combined immunodeficient (SCID) mice. PEITC and DBM in combination had stronger effects on inhibiting the growth and inducing apoptosis than either compound alone in cultured prostate cancer cells...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29574860/a-dietary-pattern-based-on-estrogen-metabolism-is-associated-with-breast-cancer-risk-in-a-prospective-cohort-of-postmenopausal-women
#20
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxylated estrogen metabolites in a subsample of Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) participants (n = 653) using reduced rank regression, and examined its association with postmenopausal breast cancer prospectively in the larger PLCO cohort (n = 27,488)...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
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