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https://www.readbyqxmd.com/read/29137077/quality-of-life-and-complications-at-the-different-stages-of-bone-transport-for-treatment-infected-nonunion-of-the-tibia
#1
Hu Wang, Xing Wei, Ping Liu, Ya-Hui Fu, Peng-Fei Wang, Yu-Xuan Cong, Bin-Fei Zhang, Zhong Li, Jin-Lai Lei, Kun Zhang, Yan Zhuang
The aim of this study was to assess Physical Component Summary (PCS), Mental Component Summary (MCS) of the Mos 36-item Short Form Health Survey (SF-36) score, and the virtual Analogue Scale (VAS) of pain during the treatment period and the complication rate associated with infected nonunion of the tibia managed surgically by bone transport.This is a retrospective analysis of prospectively collected data in a consecutive patient cohort. Patients suffering from infected nonunion of the tibia were treated by bone transport from 2012 to 2014...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29129298/latest-insights-on-the-relationship-between-symptoms-and-biologic-findings-in-adults-with-eosinophilic-esophagitis
#2
REVIEW
Ekaterina Safroneeva, Alex Straumann, Alain M Schoepfer
Patients with eosinophilic esophagitis (EoE) present with symptoms accompanied by behavioral adaptions to living with this condition. These include swallowing- and nonswallowing-associated pain in adulthood. In children, EoE symptoms vary with age and include vomiting, abdominal pain, and dysphagia. Studies using validated patient-reported outcome measures have demonstrated that symptoms in EoE are associated with severe biologic alterations and that patients on the low biologic severity spectrum have few symptoms...
January 2018: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/29121695/the-effect-of-preoperative-physical-status-on-pain-management-in-total-knee-arthroplasty-patients-receiving-adductor-canal-blockade
#3
Chukwuweike U Gwam, Jaydev B Mistry, Nequesha S Mohamed, Nicole E George, Jennifer I Etcheson, Sana Virani, Ryan Skalsky, Shreya Singh, Nicolas S Piuzzi, Ronald E Delanois
INTRODUCTION: Managing postoperative pain can be challenging for arthroplasty surgeons. While pain control modalities, such as adductor canal blockade (ACB), have been proven effective, the multifactorial nature of pain perception may serve as an obstacle for optimizing pain control. This study assesses the effect of patient pre-operative physical status on patient perception of pain. Specifically, we compared 1) lengths of hospital stay (LOS), 2) pain levels, and 3) opioid consumption in patients receiving total knee arthroplasty (TKA) who presented with an American Society of Anesthesiologists physical status score (ASA) of 2 and 3...
November 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29120935/neuropathic-pain-experiences-of-spinal-cord-injury-patients
#4
Chin-Ching Li, Hung-Ru Lin, Ming-Dar Tsai, Shiow-Luan Tsay
BACKGROUND: Neuropathic pain (NP) is a common, severe problem that affects spinal cord injury (SCI) patients. Only SCI patients truly understand the impact and extent of this type of pain. PURPOSE: The aim of this study was to understand the NP experienced by SCI patients and the influence of this type of pain on their daily life. METHOD: A qualitative design was used. An interview guide including a semistructured questionnaire and in-depth interviews was conducted with SCI patients with NP in a neurorehabilitation department at a medical center in northern Taiwan...
November 9, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29117892/emergency-department-referral-patterns-of-australian-general-practitioner-registrars-a-cross-sectional-analysis-of-prevalence-nature-and-associations
#5
Nigel Catzikiris, Amanda Tapley, Simon Morgan, Mieke van Driel, Neil Spike, Elizabeth G Holliday, Jean Ball, Kim Henderson, Lawrie McArthur, Parker Magin
Objective Limited international evidence suggests general practice registrars' emergency department (ED) referral rates exceed those of established general practitioners (GPs). The aim of the present study was to fill an evidence gap by establishing the prevalence, nature and associations of Australian GP registrar ED referrals.Methods A cross-sectional analysis was performed of the Registrar Clinical Encounters in Training (ReCEnT) cohort study of GP registrars' consultation experiences, between 2010 and 2015...
November 9, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29110807/psychobiological-correlates-of-vaginismus-an-exploratory-analysis
#6
Elisa Maseroli, Irene Scavello, Sarah Cipriani, Manuela Palma, Massimiliano Fambrini, Giovanni Corona, Edoardo Mannucci, Mario Maggi, Linda Vignozzi
BACKGROUND: Evidence concerning the determinants of vaginismus (V), in particular medical conditions, is inconclusive. AIM: To investigate, in a cohort of subjects consulting for female sexual dysfunction, whether there is a difference in medical and psychosocial parameters between women with V and women with other sexual complaints. METHODS: A series of 255 women attending our clinic for female sexual dysfunction was consecutively recruited...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29098206/medicinal-uses-and-natural-availability-of-three-plant-species-in-selected-ecosystems-in-cameroon
#7
Tsabang Nolé, Atsamo Albert, Tsambang Joel Elysée Tsafack, N Donfagsiteli, G Yedjou Clement, Tchinda Thiabo Alembert, A Agbor Gabriel, Tchounwou Paul Bernard
In many developing countries traditional medicine constitutes a major part of health care because of its local availability and affordability compared to modern medicine. However, little is known about the specific uses and availability of medicinal plants. In this research an exploratory study was conducted to determine the uses of three medicinal plants in Cameroon, and to examine their relative distribution and abundance in specific habitats. From a questionnaire administered to traditional healers, we and found that three species of medicinal plants including: Alstonia boonei, Picralima nitida and Sarcocephalus latifolius that are commonly used, either singly or in mixtures to treat human diseases such as muscle and joints pains, hyperthermia, hypertension, hepatitis, jaundice and rheumatism...
2017: J Anal Pharm Res
https://www.readbyqxmd.com/read/29094212/review-of-diabetic-frozen-shoulder
#8
REVIEW
C Whelton, C A Peach
Frozen shoulder is a painful debilitating condition which can be diagnosed clinically. It is a condition of chronic inflammation and proliferative fibrosis resulting in painful limitation of shoulder movements with classical clinical signs. Diabetic patients are more likely to develop the disease and more likely to require operative management. Diabetic frozen shoulder is a difficult condition to manage, and the clinician must strike a balance between improving range of movement and treating pain, but not over-treating what is an essentially self-resolving condition...
November 1, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29092714/pylephlebitis-presenting-as-spontaneous-coronary-sinus-thrombosis-a-case-report
#9
Michael A Hart, Mengistu A Simegn
BACKGROUND: Coronary sinus thrombosis is a rare phenomenon. When identified, it most often is a complication of infective endocarditis or procedural intervention. We present an unusual and unreported case of spontaneous coronary sinus thrombosis as embolic sequela of an intra-abdominal infectious process. CASE PRESENTATION: We report a case of a 61-year-old white woman with a history of end-stage renal disease on hemodialysis, paroxysmal atrial fibrillation not on long-term systemic anticoagulation, and history of recurrent diverticulitis that presented with acute onset abdominal pain and nausea...
November 2, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29084357/adverse-events-associated-with-medium-and-long-term-use-of-opioids-for-chronic-non-cancer-pain-an-overview-of-cochrane-reviews
#10
REVIEW
Charl Els, Tanya D Jackson, Diane Kunyk, Vernon G Lappi, Barend Sonnenberg, Reidar Hagtvedt, Sangita Sharma, Fariba Kolahdooz, Sebastian Straube
BACKGROUND: Chronic pain is common and can be challenging to manage. Despite increased utilisation of opioids, the safety and efficacy of long-term use of these compounds for chronic non-cancer pain (CNCP) remains controversial. This overview of Cochrane Reviews complements the overview entitled 'High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews'. OBJECTIVES: To provide an overview of the occurrence and nature of adverse events associated with any opioid agent (any dose, frequency, or route of administration) used on a medium- or long-term basis for the treatment of CNCP in adults...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29076746/predicting-poor-outcome-from-simple-ankle-injuries-a-prospective-cohort-study
#11
Stuart A Bullock, Georgina M Allen, Marion S Watson, David J Wilson
BACKGROUND: Sprained ankles are common and when there are no signs or evidence of a fracture, conventional management is conservative. At present, there are no clinical markers to identify those that may develop persisting instability and disability that would require rehabilitation or surgery. OBJECTIVES: To investigate the nature and extent of soft tissue ankle injuries, and to consider whether the anatomical severity of injury can predict functional outcome. METHODS: Patients attending a local Accident and Emergency Department in Oxford with an acute ankle injury with no clinical requirement for radiographs, or where radiographs were normal, were invited into the study...
November 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29070955/patellofemoral-pain-in-athletes-clinical-perspectives
#12
REVIEW
Farzin Halabchi, Maryam Abolhasani, Maryam Mirshahi, Zahra Alizadeh
Patellofemoral pain (PFP) is a very common problem in athletes who participate in jumping, cutting and pivoting sports. Several risk factors may play a part in the pathogenesis of PFP. Overuse, trauma and intrinsic risk factors are particularly important among athletes. Physical examination has a key role in PFP diagnosis. Furthermore, common risk factors should be investigated, such as hip muscle dysfunction, poor core muscle endurance, muscular tightness, excessive foot pronation and patellar malalignment...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29062240/a-randomized-phase-iib-study-investigating-oliceridine-trv130-a-novel-%C3%A2%C2%B5-receptor-g-protein-pathway-selective-%C3%AE-gps-modulator-for-the-management-of-moderate-to-severe-acute-pain-following-abdominoplasty
#13
Neil Singla, Harold S Minkowitz, David G Soergel, David A Burt, Ruth Ann Subach, Monica Y Salamea, Michael J Fossler, Franck Skobieranda
BACKGROUND: Oliceridine (TRV130), a novel μ-receptor G-protein pathway selective (μ-GPS) modulator, was designed to improve the therapeutic window of conventional opioids by activating G-protein signaling while causing low β-arrestin recruitment to the μ receptor. This randomized, double-blind, patient-controlled analgesia Phase IIb study was conducted to investigate the efficacy, safety, and tolerability of oliceridine compared with morphine and placebo in patients with moderate to severe pain following abdominoplasty (NCT02335294; oliceridine is an investigational agent not yet approved by the US Food and Drug Administration)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29053848/is-virtual-reality-ready-for-prime-time-in-the-medical-space-a-randomized-control-trial-of-pediatric-virtual-reality-for-acute-procedural-pain-management
#14
Jeffrey I Gold, Nicole E Mahrer
Objective: To conduct a randomized control trial to evaluate the feasibility and efficacy of virtual reality (VR) compared with standard of care (SOC) for reducing pain, anxiety, and improving satisfaction associated with blood draw in children ages 10-21 years. Methods: In total, 143 triads (patients, their caregiver, and the phlebotomist) were recruited in outpatient phlebotomy at a pediatric hospital and randomized to receive either VR or SOC when undergoing routine blood draw...
October 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29049119/a-review-of-opioid-sparing-modalities-in-perioperative-pain-management-methods-to-decrease-opioid-use-postoperatively
#15
REVIEW
Kanupriya Kumar, Meghan A Kirksey, Silvia Duong, Christopher L Wu
There is an epidemic of opioid use, abuse, and misuse in the United States, which results in significant morbidity and mortality. It may be difficult to reduce perioperative opioid use given known acute surgical trauma and resultant pain; however, the discrete and often limited nature of postoperative pain also may make management easier in part by utilizing nonopioid modalities, such as regional anesthesia/analgesia, and multimodal analgesia, which may decrease the need for powerful opioids. This article reviews the relevant literature describing the use of adjunct medications, regional anesthesia and analgesic techniques, and regional block additives in the context of providing adequate pain control while lessening opioid use...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29042070/geriatric-palliative-care-meeting-the-needs-of-a-growing-population
#16
Rebecca M Saracino, Mei Bai, Leslie Blatt, Larry Solomon, Ruth McCorkle
The implementation of effective geriatric palliative care (PC) services will be increasingly important as the number of patients ages ≥65 years continues to grow. However, literature characterizing the utilization of PC services by older adults remains scant. The objective of these analyses was to characterize the nature and outcomes of PC services for older adults. A retrospective analysis of records of inpatient PC consultations provided to patients ≥65 years at an academic hospital was performed (N = 743)...
October 14, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29037089/patient-reported-outcomes-in-nephrolithiasis-can-we-do-better
#17
Jonathan S Ellison, Marc Williams, Francis X Keeley
PURPOSE: Nephrolithiasis contributes significantly to the worldwide healthcare burden. Patient-reported outcome measures (PROMs) are widely recognized as important outcome measures for patient-centered care. We sought to summarize what is currently known about PROMs in urinary stone disease and to characterize use of PROMs in randomized controlled trials (RCTs) for nephrolithiasis. MATERIALS AND METHODS: Health-related quality of life (HRQOL) in patients with nephrolithiasis is reviewed...
November 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29032408/the-natural-history-of-depressive-symptoms-in-patients-with-incident-parkinson-s-disease-a-prospective-cohort-study
#18
Jan Petter Larsen, Ingvild Dalen, Kenn Freddy Pedersen, Ole-Bjørn Tysnes
Depression is common in patients with Parkinson disease and causes suffering and increased caregiver burden. A better understanding of depressive symptoms in Parkinson disease, their progression, and risk factors may, therefore, benefit management of these patients. The present study included 187 drug-naïve patients with incident PD and 166 controls from the population-based Norwegian ParkWest project. Depressive symptoms were examined with the Montgomery and Aasberg Depression Rating Scale (MADRS) at time of diagnosis and inclusion in the study and after 1, 3, 5, and 7 years of follow-up...
October 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29031874/an-update-on-the-physiopathology-and-therapeutic-management-of-cholestatic-pruritus-in-children
#19
A Thébaut, D Debray, E Gonzales
Pruritus is a disabling symptom accompanying chronic cholestasis. In extreme cases, the refractory nature of pruritus can result in a need for invasive therapies including liver transplantation. The pathogenesis of pruritus in cholestatic disease is poorly understood. It may involve a specific neural pathway (similar to that associated with pain) regulated by several pruritogenic substances such as bile acids, opioids, serotonin, and the more recently identified lysophosphatidic acid. While the therapeutic management of cholestatic pruritus is well established in adults, there is no consensus in children, in light of the difficulty of conducting controlled clinical studies...
October 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29025923/plasticity-of-signaling-by-spinal-estrogen-receptor-alpha-kappa-opioid-receptor-and-mglurs-over-the-rat-reproductive-cycle-regulates-spinal-endomorphin-2-antinociception-relevance-of-endogenous-biased-agonism
#20
Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M Storman, Stephen A Schnell, Arjun Kumar, Martin W Wessendorf, Alan R Gintzler
We previously showed that intrathecal application of endomorphin 2 [EM2; the highly specific endogenous mu-opioid receptor (MOR) ligand] induces antinociception that varies with stage of the rat estrous cycle -- minimal during diestrus and prominent during proestrus. Earlier studies, however, did not identify proestrus-activated signaling strategies that enable spinal EM2 antinociception. We now report that in female rats, increased spinal dynorphin release and kappa-opioid receptor (KOR) signaling, as well as the emergence of glutamate-activated mGluR1 signaling, are critical to the transition from an EM2 non-responsive (during diestrus) to an analgesically responsive state (during proestrus)...
October 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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