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Liver repair diet

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https://www.readbyqxmd.com/read/28752920/outcome-of-liver-transplantation-in-patients-with-prior-bariatric-surgery
#1
Mohamed Safwan, Kelly M Collins, Marwan S Abouljoud, Reena Salgia
Non-alcoholic fatty liver disease is becoming the leading cause of disease resulting in liver transplantation (LT). As a result of this trend, more liver transplant candidates are presenting with prior history of bariatric surgery (BS). Over the last decade, 960 patients underwent LT at our institution; 11 (1.1%) had prior BS. Most common type of BS was Roux-en-Y gastric bypass (n=9) with 1 sleeve gastrectomy and 1 jejunoileal bypass. Nine patients underwent LT alone and 2 underwent simultaneous liver-kidney transplantation...
July 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28676836/genetic-nrf2-overactivation-inhibits-the-deleterious-effects-induced-by-hepatocyte-specific-c-met-deletion-during-the-progression-of-nash
#2
Pierluigi Ramadori, Hannah Drescher, Stephanie Erschfeld, Athanassios Fragoulis, Thomas W Kensler, Christoph Jan Wruck, Francisco Javier Cubero, Christian Trautwein, Konrad L Streetz, Daniela C Kroy
We have recently shown that hepatocyte-specific c-met deficiency accelerates the progression of nonalcoholic steatohepatitis in experimental murine models resulting in augmented production of reactive oxygen species and accelerated development of fibrosis. The aim of this study focuses on the elucidation of the underlying cellular mechanisms driven by Nrf2 overactivation in hepatocytes lacking c-met receptor characterized by a severe unbalance between pro-oxidant and antioxidant functions. Control mice (c-met(fx/fx)), single c-met knockouts (c-met(Δhepa)), and double c-met/Keap1 knockouts (met/Keap1(Δhepa)) were then fed a chow or a methionine-choline-deficient (MCD) diet, respectively, for 4 weeks to reproduce the features of nonalcoholic steatohepatitis...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28622357/protective-effect-of-aplysin-on-liver-tissue-and-the-gut-microbiota-in-alcohol-fed-rats
#3
Meilan Xue, Ying Liu, Rui Lyu, Na Ge, Man Liu, Yan Ma, Hui Liang
BACKGROUND: This study investigated the protective effect of aplysin on the liver and its influence on inflammation and the gut microbiota in rats with ethanol-induced liver injury. METHODS: Male Sprague-Dawley rats were randomly assigned to an alcohol-containing liquid diet, control liquid diet or treatment with aplysin for 8 weeks. Hepatic and intestinal histopathological analysis was performed, and cytokine levels and the intestinal mucosal barrier were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28613268/vitamin-e-modifies-high-fat-diet-induced-increase-of-dna-strand-breaks-and-changes-in-expression-and-dna-methylation-of-dnmt1-and-mlh1-in-c57bl-6j-male-mice
#4
Marlene Remely, Franziska Ferk, Sonja Sterneder, Tahereh Setayesh, Tatjana Kepcija, Sylvia Roth, Rahil Noorizadeh, Martina Greunz, Irene Rebhan, Karl-Heinz Wagner, Siegfried Knasmüller, Alexander Haslberger
Obesity is associated with low-grade inflammation, increased ROS production and DNA damage. Supplementation with antioxidants might ameliorate DNA damage and support epigenetic regulation of DNA repair. C57BL/6J male mice were fed a high-fat (HFD) or a control diet (CD) with and without vitamin E supplementation (4.5 mg/kg body weight (b.w.)) for four months. DNA damage, DNA promoter methylation and gene expression of Dnmt1 and a DNA repair gene (MLH1) were assayed in liver and colon. The HFD resulted in organ specific changes in DNA damage, the epigenetically important Dnmt1 gene, and the DNA repair gene MLH1...
June 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28338610/fructose-rich-diet-affects-mitochondrial-dna-damage-and-repair-in-rats
#5
Federica Cioffi, Rosalba Senese, Pasquale Lasala, Angela Ziello, Arianna Mazzoli, Raffaella Crescenzo, Giovanna Liverini, Antonia Lanni, Fernando Goglia, Susanna Iossa
Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in metabolic disease resulting from a fructose-rich diet. In the present study, we evaluated the degree of oxidative damage to liver mtDNA and its repair, in addition to the state of oxidative stress and antioxidant defense in the liver of rats fed a high-fructose diet...
March 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28163112/antidiabetic-effects-of-morus-alba-fruit-polysaccharides-on-high-fat-diet-and-streptozotocin-induced-type-2-diabetes-in-rats
#6
Yukun Jiao, Xueqian Wang, Xiang Jiang, Fansheng Kong, Shumei Wang, Chunyan Yan
ETHNOPHARMACOLOGICAL RELEVANCE: Type 2 diabetes mellitus (T2DM) is becoming a serious threat to human health. The fruit of Morus alba L. is widely used as a traditional Chinese medicine for the treatment of DM, dizziness, tinnitus, insomnia, and premature graying, as well as to protect the liver and kidneys. Several studies have demonstrated that the aqueous extracts of the roots bark, leaves, and ramuli of mulberry, which are known to contain polyphenols and polysaccharides, have antihyperglycemic and antihyperlipidemic activities...
March 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27749006/an-extra-virgin-olive-oil-rich-diet-intervention-ameliorates-the-nonalcoholic-steatohepatitis-induced-by-a-high-fat-western-type-diet-in-mice
#7
Enrique Jurado-Ruiz, Lourdes M Varela, Amparo Luque, Genoveva Berná, Gladys Cahuana, Enrique Martinez-Force, Rocío Gallego-Durán, Bernat Soria, Baukje de Roos, Manuel Romero Gómez, Franz Martín
SCOPE: We evaluated the protective effect of extra virgin olive oil (EVOO) in high-fat diets (HFDs) on the inflammatory response and liver damage in a nonalcoholic fatty liver disease (NAFLD) mouse model. METHODS AND RESULTS: C57BL/6J mice were fed a standard diet or a lard-based HFD (HFD-L) for 12 wk to develop NAFLD. HFD-fed mice were then divided into four groups and fed for 24 wk with the following: HFD-L, HFD-EVOO, HFD based on phenolics-rich EVOO, and reversion (standard diet)...
October 17, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27635189/liver-cholesterol-overload-aggravates-obstructive-cholestasis-by-inducing-oxidative-stress-and-premature-death-in-mice
#8
Natalia Nuño-Lámbarri, Mayra Domínguez-Pérez, Anna Baulies-Domenech, Maria J Monte, Jose J G Marin, Patricia Rosales-Cruz, Verónica Souza, Roxana U Miranda, Leticia Bucio, Eduardo E Montalvo-Jave, María Concepción Gutiérrez-Ruiz, Carmen García-Ruiz, José C Fernández-Checa, Luis Enrique Gomez-Quiroz
Nonalcoholic steatohepatitis is one of the leading causes of liver disease. Dietary factors determine the clinical presentation of steatohepatitis and can influence the progression of related diseases. Cholesterol has emerged as a critical player in the disease and hence consumption of cholesterol-enriched diets can lead to a progressive form of the disease. The aim was to investigate the impact of liver cholesterol overload on the progression of the obstructive cholestasis in mice subjected to bile duct ligation surgery...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27609769/weight-loss-following-diet-induced-obesity-does-not-alter-colon-tumorigenesis-in-the-aom-mouse-model
#9
Kandy T Velázquez, Reilly T Enos, Meredith S Carson, Taryn L Cranford, Jackie E Bader, Ioulia Chatzistamou, Udai P Singh, Prakash S Nagarkatti, Mitzi Nagarkatti, J Mark Davis, James A Carson, E Angela Murphy
Obesity presents a significant public health concern given its association with increased cancer incidence, unfavorable prognosis, and metastasis. However, there is very little literature on the effects of weight loss, following obesity, on risk for colon cancer or liver cancer. Therefore, we sought to study whether intentional weight loss through diet manipulation was capable of mitigating colon and liver cancer in mice. We fed mice with a high-fat diet (HFD) comprised of 47% carbohydrates, 40% fat, and 13% protein for 20 wk to mimic human obesity...
October 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27556946/restricted-diet-delays-accelerated-ageing-and-genomic-stress-in-dna-repair-deficient-mice
#10
W P Vermeij, M E T Dollé, E Reiling, D Jaarsma, C Payan-Gomez, C R Bombardieri, H Wu, A J M Roks, S M Botter, B C van der Eerden, S A Youssef, R V Kuiper, B Nagarajah, C T van Oostrom, R M C Brandt, S Barnhoorn, S Imholz, J L A Pennings, A de Bruin, Á Gyenis, J Pothof, J Vijg, H van Steeg, J H J Hoeijmakers
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1(∆/-)) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ageing response induced by dietary restriction (also known as caloric restriction). Here we report that a dietary restriction of 30% tripled the median and maximal remaining lifespans of these progeroid mice, strongly retarding numerous aspects of accelerated ageing...
September 15, 2016: Nature
https://www.readbyqxmd.com/read/27497985/berberine-attenuates-oxidative-stress-and-hepatocytes-apoptosis-via-protecting-mitochondria-in-blunt-snout-bream-megalobrama-amblycephala-fed-high-fat-diets
#11
Kang-Le Lu, Li-Na Wang, Ding-Dong Zhang, Wen-Bin Liu, Wei-Na Xu
High-fat diets may have favorable effects on growth and cost, but high-fat diets often induce excessive fat deposition, resulting in liver damage. This study aimed to identify the hepatoprotective of a Chinese herb (berberine) for blunt snout bream (Megalobrama amblycephala). Fish were fed with a normal diet (LFD, 5 % fat), high-fat diet (HFD, 15 % fat) or berberine-supplemented diets (BSD, 15 % fat with berberine 50 or 100 mg/kg level) for 8 weeks. After the feeding, histology, oxidative status and mitochondrial function of liver were assessed...
February 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27233965/the-ron-receptor-tyrosine-kinase-regulates-macrophage-heterogeneity-and-plays-a-protective-role-in-diet-induced-obesity-atherosclerosis-and-hepatosteatosis
#12
Shan Yu, Joselyn N Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J Kennett, Mingcan Xia, Na Xiong, Jeffrey M Peters, Andrew Patterson, Pamela A Hankey-Giblin
Obesity is a chronic inflammatory disease mediated in large part by the activation of inflammatory macrophages. This chronic inflammation underlies a whole host of diseases including atherosclerosis, hepatic steatosis, insulin resistance, type 2 diabetes, and cancer, among others. Macrophages are generally classified as either inflammatory or alternatively activated. Some tissue-resident macrophages are derived from yolk sac erythromyeloid progenitors and fetal liver progenitors that seed tissues during embryogenesis and have the ability to repopulate through local proliferation...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27126624/laparoscopic-redo-hepaticojejunostomy-for-children-with-choledochal-cysts
#13
Mei Diao, Long Li, Wei Cheng
BACKGROUND: The current study is to evaluate the long-term efficacy of laparoscopic redo hepaticojejunostomy (LRH) for children with cholecochal cysts (CDCs). METHODS: Between January 2006 and January 2016, 44 CDC children who had biliary re-obstructions after primary definitive surgeries successfully underwent LRH in our hospital. The hepatic arteries were repositioned behind Roux loop. Ductoplasties and wide hepaticojejunostomies were carried out. The operative time, postoperative recovery and complications were compared with our open redo hepaticojejunostomy (ORH, n = 16) between October 2001 and December 2005...
December 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27096691/non-alcoholic-steatohepatitis-clinical-and-translational-research
#14
REVIEW
Manuela G Neuman, Mihai Voiculescu, Radu M Nanau, Yaakov Maor, Ehud Melzer, Lawrence B Cohen, Mihai Opris, Stephen Malnick
UNLABELLED: The present review includes translational and clinical research that characterize non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Clinical and experimental evidence led to the recognition of the key toxic role played by lipotoxicity in the pathogenesis of NAFLD. The current understanding of lipotoxicity suggests that organ injury is initiated by the generation of oxidative metabolites and the translocation of gut-derived endotoxin. These processes lead to cellular injury and stimulation of the inflammatory responses mediated through a variety of molecules...
2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26670291/attrition-of-hepatic-damage-inflicted-by-angiotensin-ii-with-%C3%AE-tocopherol-and-%C3%AE-carotene-in-experimental-apolipoprotein-e-knock-out-mice
#15
Kaliappan Gopal, Munusamy Gowtham, Singh Sachin, Mani Ravishankar Ram, Esaki M Shankar, Tunku Kamarul
Angiotensin II is one of the key regulatory peptides implicated in the pathogenesis of liver disease. The mechanisms underlying the salubrious role of α-tocopherol and β-carotene on liver pathology have not been comprehensively assessed. Here, we investigated the mechanisms underlying the role of Angiotensin II on hepatic damage and if α-tocopherol and β-carotene supplementation attenuates hepatic damage. Hepatic damage was induced in Apoe(-/-)mice by infusion of Angiotensin II followed by oral administration with α-tocopherol and β-carotene-enriched diet for 60 days...
December 16, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26622336/biological-effects-of-pyrroloquinoline-quinone-on-liver-damage-in-bmi-1-knockout-mice
#16
Yuanqing Huang, Ning Chen, Dengshun Miao
Pyrroloquinoline quinone (PQQ) has been demonstrated to function as an antioxidant by scavenging free radicals and subsequently protecting the mitochondria from oxidative stress-induced damage. The aim of the present study was to investigate whether PQQ is able to rescue premature senescence in the liver, induced by the deletion of B cell-specific Moloney MLV insertion site-1 (Bmi-1), by inhibiting oxidative stress. In vivo, the mice were allocated into three groups that underwent the following treatment protocols...
August 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26599547/glycoprotein-nonmetastatic-melanoma-b-gpnmb-positive-macrophages-contribute-to-the-balance-between-fibrosis-and-fibrolysis-during-the-repair-of-acute-liver-injury-in-mice
#17
Kotaro Kumagai, Kazuaki Tabu, Fumisato Sasaki, Yoichiro Takami, Yuko Morinaga, Seiichi Mawatari, Shinichi Hashimoto, Shiroh Tanoue, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido
BACKGROUND AND AIMS: Glycoprotein nonmetastatic melanoma B (Gpnmb), a transmembrane glycoprotein that is expressed in macrophages, negatively regulates inflammation. We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino acid-defined (CDAA) diet. However, the role of macrophage-expressed Gpnmb in liver injury is still unknown. This study aimed to clarify the characteristics of infiltrating macrophages that express Gpnmb, and the involvement of Gpnmb in the repair process in response to liver injury...
2015: PloS One
https://www.readbyqxmd.com/read/26496771/a-modified-choline-deficient-ethionine-supplemented-diet-reduces-morbidity-and-retains-a-liver-progenitor-cell-response-in-mice
#18
Adam M Passman, Robyn P Strauss, Sarah B McSpadden, Megan L Finch-Edmondson, Ken H Woo, Luke A Diepeveen, Roslyn London, Bernard A Callus, George C Yeoh
The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing studies show that LPCs differentiate into functional hepatocytes in this model. The CDE diet was first modified for mice by our laboratory by separately administering choline-deficient chow and ethionine in the drinking water (CD+E diet). Although this CD+E diet is widely used, concerns with variability in weight loss, morbidity, mortality and LPC response have been raised by researchers who have adopted this model...
December 2015: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/26473743/inhibition-of-hedgehog-signaling-ameliorates-hepatic-inflammation-in-mice-with-nonalcoholic-fatty-liver-disease
#19
COMPARATIVE STUDY
Hyunjoo Kwon, Kyoungsub Song, Chang Han, Weina Chen, Ying Wang, Srikanta Dash, Kyu Lim, Tong Wu
UNLABELLED: Hedgehog (Hh) signaling plays a critical role in liver development, regeneration, injury repair, and carcinogenesis. Activation of Hh signaling has been observed in patients with nonalcoholic fatty liver diseases (NAFLD); however, the pathobiological function and regulatory mechanism of hepatic Hh signaling in the pathogenesis of NAFLD remain to be further defined. This study was designed to examine the effect and mechanism of hepatic Hh signaling in high-fat diet-induced NAFLD by using pharmacological Smoothened (Smo) inhibitors (GDC-0449 and LED225) and liver-specific Smo knockout mice...
April 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/26290021/-cholesterol-overload-in-hepatocytes-affects-nicotinamide-adenine-dinucleotide-phosphate-oxidase-nadph-activity-abrogating-hepatocyte-growth-factor-hgf-induced-cellular-protection
#20
Alberto G López-Reyes, Karina Martínez-Flores, Denise Clavijo-Cornejo, Natalia Nuño-Lámbarri, Mayrel Palestino-Domínguez, Verónica Souza, Leticia Bucio, Arturo Panduro, Roxana U Miranda, Luis Enrique Gómez-Quiroz, María Concepción Gutiérrez-Ruiz
The increment in the prevalence of obesity incidence in Mexico is leading to the increase in many chronic maladies, including liver diseases. It is well known that lipid-induced liver sensitization is related to the kind of lipid rather than the amount of them in the organ. Cholesterol overload in the liver aggravates the toxic effects of canonical liver insults. However, the status on the repair and survival response elicited by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the hepatocyte growth factor (HGF) is not completely understood...
July 2015: Gaceta Médica de México
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