Brett M Frye, Jacob D Negrey, Corbin S C Johnson, Jeongchul Kim, Richard A Barcus, Samuel N Lockhart, Christopher T Whitlow, Kenneth L Chiou, Noah Snyder-Mackler, Thomas J Montine, Suzanne Craft, Carol A Shively, Thomas C Register
Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood. We assessed the effects of Western versus Mediterranean-like diets on RNAseq-generated transcriptional profiles in lateral temporal cortex and their relationships with longitudinal changes in neuroanatomy, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques (Macaca fascicularis)...
April 16, 2024: Brain, Behavior, and Immunity