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Hilar cholangiocarcinoma

Qihong Ni, Haolu Wang, Yunhe Zhang, Lijun Qian, Jiachang Chi, Xiaowen Liang, Tao Chen, Jian Wang
PURPOSE: The purpose of this study is to investigate the value of multidetector computed tomography (MDCT) assessment of resectability in hilar cholangiocarcinoma, and to identify the factors associated with unresectability and accurate evaluation of resectability. METHODS: From January 2007 to June 2015, a total of 77 consecutive patients were included. All patients had preoperative MDCT (with MPR and MinIP) and surgical treatment, and were pathologically proven with hilar cholangiocarcinoma...
October 21, 2016: Abdominal Radiology
Wen-Jie Ma, Anuj Shrestha, Fu-Yu Li
Mantel et al. showed that the use of intraoperative frozen section analysis of the proximal bile ducts has a limited contribution in obtaining secondary R0 resections and final resection status had no impact on recurrence rate in hilar cholangiocarcinoma. However, the accuracy, sensitivity, and specificity of intraoperative frozen section analysis were determined by the specific pathologic features of the tumor and the different experienced pathologists in different pathology laboratories. It has been demonstrated that tumor-free resection margin (R0) is the most prognostic factor for survival, as well as the only factor that can be modified by the surgeons...
September 29, 2016: Cancer Medicine
W C Jackson, L Bazzi, E Sapir, T S Lawrence, M Feng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Yunhong Tian, Lei Liu, Ninad V Yeolkar, Feng Shen, Jun Li, Zhenxing He
BACKGROUND: Accurate preoperative radiological staging of biliary cancers remains difficult. Despite the improvement in imaging techniques, a number of patients with biliary cancers who undergo laparotomy are ultimately found to have unresectable diseases. The goals of staging laparoscopy (SL) are to rule out metastatic and locally advanced unresectable diseases and better define locally advanced unresectable diseases. This study evaluates the efficiency of SL in ruling out unresectable disease in a subset of biliary cancers...
September 20, 2016: ANZ Journal of Surgery
Xiang-de Shi, Xian-Huan Yu, Wen-Rui Wu, Xiao-Lin Xu, Jie-Yu Wang, Lei-Bo Xu, Rui Zhang, Chao Liu
Dickkopf-1 (DKK1) is involved in tumorigenesis and the invasion of several tumors. However, its biological function in human hilar cholangiocarcinoma (HCCA) has not yet been documented. This study was designed to investigate the clinical significance and biological function of DKK1 in HCCA. The expression of DKK1 was investigated in thirty-seven human HCCA biopsy samples by immunohistochemistry. To further explore the biological effects of DKK1 in HCCA, transient and stable knockdown of DKK1 in two human HCCA cells (QBC939 and FRH0201) were established using small interfering or short hairpin RNA expression vector...
September 6, 2016: Oncotarget
Itaru Endo, Ryusei Matsuyama, Ryutaro Mori
No abstract text is available yet for this article.
September 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Hiroyuki Maguchi, Akio Katanuma, Kuniyuki Takahashi
No abstract text is available yet for this article.
September 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Tomoki Ebata, Takashi Mizuno, Masato Nagino
No abstract text is available yet for this article.
September 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
N Zeng, C H Fang, Y F Fan, J Yang, N Xiang, W Zhu, J Liu, W Cai, Z K Mo
OBJECTIVE: To explore the construction and clinical efficacy of three-dimensional(3D) visualization platform about diagnosis and treatment of hilar cholangiocarcinoma. METHODS: From January 2009 to December 2015, a total of 32 patients with hilarcholangiocarcinoma treated in Zhujiang Hospital of Southern Medical University were analyzed.There were 20 male and 12 female patients aged from 40 to 85 years. Bismuth-Corlette 3D visualization type: 2 cases with type Ⅰ, 5 cases with type Ⅱ, 10 cases with type Ⅲa, 11 cases with type Ⅲb, 4 cases with type Ⅳ...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Binhao Zhang, Wei Dong, Hongping Luo, Xuanru Zhu, Lin Chen, Changhai Li, Peng Zhu, Wei Zhang, Shuai Xiang, Wanguang Zhang, Zhiyong Huang, Xiao-Ping Chen
Hepato-pancreato-biliary (HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/ advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures...
October 2016: Science China. Life Sciences
Felice Giuliante, Francesco Ardito, Alfredo Guglielmi, Luca Aldrighetti, Alessandro Ferrero, Fulvio Calise, Stefano M Giulini, Elio Jovine, Claudio Breccia, Agostino M De Rose, Antonio D Pinna, Gennaro Nuzzo
Importance: The prognostic value of lymph node (LN) assessment after liver resection for hilar cholangiocarcinoma (HC) is still controversial, and the number of LNs required to be removed to obtain adequate staging is not well defined. Objectives: To evaluate the LN status in patients after liver resection for HC and to clarify which prognostic factor (the number of positive LNs or the LN ratio [LNR]) was most accurate for staging and what minimum number of retrieved LNs was required for adequate staging...
August 24, 2016: JAMA Surgery
Seungha Hwang, Tae Jun Song, Seol So, Min Kyung Jeon, Eun Hye Oh, Byoung Soo Kwon, Sujong An, Myung Hwan Kim
Primary biliary mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare. We report a case of primary biliary MALT lymphoma with obstructive jaundice diagnosed by endoscopic biopsy, without surgical intervention. Obstructive jaundice was relieved by endoscopic drainage and endoscopic biopsy was done simultaneously during endoscopic retrograde cholangiopancreatography. Unnecessary surgical intervention can be avoided after pathological confirmation of lymphoma. The patient received radiotherapy, and is alive without any evidence of recurrence or biliary obstruction...
August 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Gaya Spolverato, Fabio Bagante, Cecilia G Ethun, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley Krasnick, Emily Winslow, Clifford Cho, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: While surgery offers the best curative-intent treatment, many patients with biliary tract malignancies have poor long-term outcomes. We sought to apply a non-mixture cure model to calculate the cure fraction and the time to cure after surgery of patients with peri-hilar cholangiocarcinoma (PHCC) or gallbladder cancer (GBC). METHODS: Using the Extrahepatic Biliary Malignancy Consortium, 576 patients who underwent curative-intent surgery for gallbladder carcinoma or peri-hilar cholangiocarcinoma between 1998 and 2014 at 10 major hepatobiliary institutions were identified and included in the analysis...
August 22, 2016: World Journal of Surgery
A Schmidt, M Bloechinger, A Weber, J Siveke, S von Delius, C Prinz, W Schmitt, R M Schmid, B Neu
BACKGROUND AND STUDY AIMS: Radiofrequency ablation (RFA) is a new endoscopic palliation therapy for malignant biliary obstruction. The aim of this study was to compare the short-term effects of biliary drainage and adverse events of this technique with the standard of endoscopical treatment of hilar cholangiocarcinoma, photodynamic therapy (PDT). PATIENTS AND METHODS: We retrospectively and since December 2012 prospectively investigated the efficacy and adverse events of RFA in patients with hilar cholangiocarcinoma in two tertiary referral centers between November 2011 and January 2013...
August 2016: United European Gastroenterology Journal
Jane Lim, Nicholas N Nissen, Christopher McPhaul, Alagappan Annamalai, Andrew S Klein, Vinay Sundaram
Peribiliary cysts are cystic dilatations of peribiliary glands in the liver. They are present in ~50% of cirrhotic patients, but are underrecognized because they are usually asymptomatic and rarely present as obstructive jaundice. A 63-year-old male with hepatitis C cirrhosis, awaiting liver transplantation, had a new finding of intrahepatic dilatation on magnetic resonance imaging. This was initially concerning for cholangiocarcinoma, but was ultimately diagnosed as peribiliary cysts. Peribiliary cysts can imitate cholangiocarcinoma on imaging...
2016: Journal of Surgical Case Reports
Georgi Atanasov, Katrin Schierle, Hans-Michael Hau, Corinna Dietel, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Julianna Paulina Englisch, Simon C Robson, Anja Reutzel-Selke, Andreas Pascher, Sven Jonas, Johann Pratschke, Christian Benzing, Moritz Schmelzle
BACKGROUND: Tumor necrosis and peritumoral fibrosis have both been suggested to have a prognostic value in selected solid tumors. However, little is known regarding their influence on tumor progression and prognosis in hilar cholangiocarcinoma (HC). METHODS: Surgically resected tumor specimens of HC (n = 47) were analyzed for formation of necrosis and extent of peritumoral fibrosis. Tumor necrosis and grade of fibrosis were assessed histologically and correlated with clinicopathological characteristics, tumor recurrence, and patients' survival...
August 1, 2016: Annals of Surgical Oncology
Huan-Ling Guo, Li-da Chen, Zhu Wang, Yang Huang, Jin-Ya Liu, Quan-Yuan Shan, Xiao-Yan Xie, Ming-de Lu, Wei Wang
Solitary neurofibroma located in the hilum of the liver is extremely rare, particularly without neurofibromatosis. We herein report a case of hilar biliary neurofibroma without signs of von Recklinghausen's disease. A 36-year-old man was admitted to our department with progressive jaundice. The case was diagnosed as hilar cholangiocarcinoma based on preoperative imaging. The patient consequently received a Roux-en-Y hepaticojejunostomy and was confirmed with neurofibroma pathologically. This is the first reported imaging finding of hilar biliary neurofibroma using contrast-enhanced ultrasound, emphasizing the differential diagnosis of biliary tumors...
October 2016: Journal of Medical Ultrasonics
Kamal Sunder Yadav, Priyanka Akhilesh Sali, Verushka M Mansukhani, Rajiv Shah, P Jagannath
IgG4-sclerosing cholangitis (IgG4-SC) commonly presents with type 1 autoimmune pancreatitis. Isolated IgG4-SC is rare. Differentiating IgG4-SC from cholangiocarcinoma preoperatively is challenging due to overlapping radio-clinical manifestations and difficult preoperative histology. We present three cases preoperatively diagnosed and surgically treated as hilar cholangiocarcinoma. First and second cases presented with cholangiocarcinoma with portal vein involvement and third with a malignant-appearing hilar stricture...
July 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Kohei Fujikura, Takumi Fukumoto, Tetsuo Ajiki, Kyoko Otani, Maki Kanzawa, Masayuki Akita, Masahiro Kido, Yonson Ku, Tomoo Itoh, Yoh Zen
AIMS: This study was aimed to achieve a better definition of intraductal papillary neoplasms of the bile duct (IPNBs). METHODS AND RESULTS: Biliary tumours that showed predominantly intraductal papillary growth were provisionally classified into IPNBs (n=25) and papillary cholangiocarcinomas (n=27). IPNB was defined as a neoplasm that is confined to the epithelium or is regularly arranged in a high-papillary architecture along thin fibrovascular stalks, while the term "papillary cholangiocarcinoma" was used for tumours with more complex papillary structures (e...
July 13, 2016: Histopathology
Abhijeet Waghray, Anastasia Sobotka, Carlos Romero Marrero, Bassam Estfan, Federico Aucejo, K V Narayanan Menon
BACKGROUND AND AIMS: Hilar cholangiocarcinoma is a devastating malignancy with incidence varying by geography and other risk factors. Rapid progression of disease and delays in diagnosis restrict the number of patients eligible for curative therapy. The objective of this study was to determine prognostic factors of overall survival in all patients presenting with hilar cholangiocarcinoma. METHODS: All adult patients with histologically confirmed hilar cholangiocarcinoma from 2003 to 2013 were evaluated for predictors of survival using demographic factors, laboratory data, symptoms and radiological characteristics at presentation...
July 6, 2016: Gastroenterology Report
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