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https://www.readbyqxmd.com/read/28806856/direct-cell-labeling-to-image-transplanted-stem-cells-in-real-time-using-a-dual-contrast-mri-technique
#1
Ethel J Ngen, Yoshinori Kato, Dmitri Artemov
Exogenous direct cell labeling with superparamagnetic iron oxide nanoparticles (SPIONs) is currently the most employed cell-labeling technique for tracking transplanted cells using magnetic resonance imaging (MRI). Although SPION-based cell labeling is effective for monitoring cell delivery and migration, monitoring cell survival is still a challenge. This unit describes an MRI technique that permits detection of the delivery, migration, and death of transplanted cells. This dual-contrast technique involves labeling cells with two different classes of MRI contrast agents, possessing different diffusion coefficients: SPIONs (T2 /T2(*) contrast agents, with lower diffusion coefficients) and gadolinium chelates (T1 contrast agents, with higher diffusion coefficients)...
August 14, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28806655/magnetic-reduced-graphene-oxide-loaded-hydrogels-highly-versatile-and-efficient-adsorbents-for-dyes-and-selective-cr-vi-ions-removal
#2
Fatima Halouane, Yavuz Oz, Dalila Meziane, Alexandre Barras, Jean Juraszek, Santosh K Singh, Sreekumar Kurungot, Pankaj K Shaw, Rana Sanyal, Rabah Boukherroub, Amitav Sanyal, Sabine Szunerits
The formation of composites of reduced graphene oxide (rGO) and magnetic nanoparticles (MP) has flourished in recent years as they combine the advantages of both nanomaterials. Most of these composite materials are prepared by in situ formation of MP onto rGO or by the post-adsorption onto rGO. We report here on a simple and highly controlled method for the fabrication of different magnetic 3D rGO-loaded hydrogels. Cellulose bound magnetic nanoparticles (MP@cellulose) were synthesized by chemical co-precipitation and loaded together with rGO into poly(ethylene glycol) dimethacrylate based hydrogels during their fabrication using photo-polymerization...
July 28, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806654/magnetic-separable-chitosan-microcapsules-decorated-with-silver-nanoparticles-for-catalytic-reduction-of-4-nitrophenol
#3
Peng Xu, Xuguang Liang, Nannan Chen, Jingen Tang, Wei Shao, Qinwei Gao, Zhaogang Teng
In the work, we have synthesized silver (Ag) nanoparticles deposited chitosan (CS) microcapsules with magnetic multiple Fe3O4 cores (denoted as Fe3O4/CS-Ag) as efficient catalysts for the reduction of 4-nitrophenol. The Fe3O4/CS-Ag catalysts are prepared by coating hydrophobic Fe3O4 nanoparticles with chitosan via a multiple emulsion-chemical crosslinking method and following in situ deposition of Ag nanoparticles onto the surfaces. The morphology and composition of the Fe3O4/CS-Ag microcapsules are characterized by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy...
August 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28805690/preparation-of-magnetic-nanoparticles-via-a-chemically-induced-transition-role-of-treating-solution-s-temperature
#4
Ting Zhang, Xiangshen Meng, Zhenghong He, Yueqiang Lin, Xiaodong Liu, Decai Li, Jian Li, Xiaoyan Qiu
Using FeOOH/Mg(OH)₂ as precursor and FeCl₂ as the treating solution, we prepared γ-Fe₂O₃ based nanoparticles. The FeCl₂ treating solution catalyzes the chemical reactions, dismutation and oxygenation, leading to the formation of products FeCl₃ and Fe₂O₃, respectively. The treating solution (FeCl₂) accelerates dehydration of the FeOOH compound in the precursor and transforms it into the initial seed crystallite γ-Fe₂O₃. Fe₂O₃ grows epitaxially on the initial seed crystallite γ-Fe₂O₃...
August 12, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28804578/using-nanoparticles-in-medicine-for-liver-cancer-imaging
#5
REVIEW
Farideh Farokhi Moghadam
One of the most important types of liver cancer is hepatocellular carcinoma (HCC). HCC is the fifth most common cancer, and its correct diagnosis is very important. For the quick diagnosis of HCC, the use of nanoparticles is helpful. The major applications of nanoparticles are in medicine for organ imaging. Two methods of liver imaging are X-ray computed tomography (CT) and magnetic resonance imaging (MRI). In this review, we attempt to summarize some of the contrast agents used in imaging such as superparamagnetic iron oxide nanoparticles (SPIONs) and iron oxide nanoparticles (IONPs), various types of enhanced MRI for the liver, and nanoparticles like gold (AuNPs), which is used to develop novel CT imaging agents...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28802174/synthesis-and-characterization-of-mno2-nio-nanocomposites-for-photocatalysis-of-tetracycline-antibiotic-and-modification-with-guanidine-for-carriers-of-caffeic-acid-phenethyl-ester-an-anticancer-drug
#6
Vinod Kumar Gupta, Ali Fakhri, Shilpi Agarwal, Elham Ahmadi, Pedram Afshar Nejad
In the present studies, modified NiO nanoparticles and MnO2/NiO nanocomposites with guanidine were synthesized by anchoring method for carriers of anticancer drug "Caffeic acid phenethyl ester". The prepared nanocomposites were characterized by using Scanning Electron Microscopy, Raman and Fourier transform infrared spectroscopy, X-ray diffraction, Vibrating sample magnetometer. The results from XRD indicated that the crystalline size of NiO nanoparticles and MnO2/NiO nanocomposites are 12 and 15nm, respectively...
August 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28800071/fabrication-and-characterization-of-magnesium-ferrite-based-pcl-aloe-vera-nanofibers
#7
Zanshe Thompson, Shekh Rahman, Sergey Yarmolenko, Jagannathan Sankar, Dhananjay Kumar, Narayan Bhattarai
Composite nanofibers of biopolymers and inorganic materials have been widely explored as tissue engineering scaffolds because of their superior structural, mechanical and biological properties. In this study, magnesium ferrite (Mg-ferrite) based composite nanofibers were synthesized using an electrospinning technique. Mg-ferrite nanoparticles were first synthesized using the reverse micelle method, and then blended in a mixture of polycaprolactone (PCL), a synthetic polymer, and Aloe vera, a natural polymer, to create magnetic nanofibers by electrospinning...
August 11, 2017: Materials
https://www.readbyqxmd.com/read/28799931/study-on-non-linear-equilibrium-kinetics-and-thermodynamic-of-deltamethrin-removal-in-aqueous-solution-using-modified-magnetic-iron-oxide-nanoparticles
#8
Bahareh Ghafari, Elham Moniri, Homayon Ahmad Panahi, Abdolreza Karbassi, Shaban Najafpour
The purpose of modification of magnetic iron oxide nanoparticles is an eco-friendly, emerging and economical method for removing deltamethrin in the aqueous solution and wastewater effluents when compared with other adsorbent methods. Modified magnetic iron oxide nanoparticles were synthesized by co-precipitation and then coupled with 3-hydroxytyraminium chloride. The nano-sorbent was characterized by thermogravimetric analysis, elemental analysis, transmission electron microscopy, scanning electron microscope, Fourier transform infrared spectroscopy, zero point charge and surface area determination...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28799116/targeting-endothelial-cells-with-multifunctional-gan-fe-nanoparticles
#9
Tudor Braniste, Ion Tiginyanu, Tibor Horvath, Simion Raevschi, Birgit Andrée, Serghei Cebotari, Erin C Boyle, Axel Haverich, Andres Hilfiker
In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high temperature. Using transmission electron microscopy, we demonstrate that porcine aortic endothelial cells take up GaN-based nanoparticles suspended in the growth medium. The nanoparticles are deposited in vesicles and the endothelial cells show no sign of cellular damage...
August 10, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28798883/magnetic-solid-phase-extraction-using-fe3o4-sio2-magnetic-nanoparticles-followed-by-uv-vis-spectrometry-for-determination-of-paraquat-in-plasma-and-urine-samples
#10
Ou Sha, Yu Wang, Xin Yin, Xiaobing Chen, Li Chen, Shujun Wang
A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28798327/assessing-cell-nanoparticle-interactions-by-high-content-imaging-of-biocompatible-iron-oxide-nanoparticles-as-potential-contrast-agents-for-magnetic-resonance-imaging
#11
Roxanne Hachani, Martin A Birchall, Mark W Lowdell, Georgios Kasparis, Le D Tung, Bella B Manshian, Stefaan J Soenen, Willy Gsell, Uwe Himmelreich, Codi A Gharagouzloo, Srinivas Sridhar, Nguyen T K Thanh
Stem cell tracking in cellular therapy and regenerative medicine is an urgent need, superparamagnetic iron oxide nanoparticles (IONPs) could be used as contrast agents in magnetic resonance imaging (MRI) that allows visualization of the implanted cells ensuring they reach the desired sites in vivo. Herein, we report the study of the interaction of 3,4-dihydroxyhydrocinnamic acid (DHCA) functionalized IONPs that have desirable properties for T2 - weighted MRI, with bone marrow-derived primary human mesenchymal stem cells (hMSCs)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796540/recent-advances-in-targeted-delivery-of-tissue-plasminogen-activator-for-enhanced-thrombolysis-in-ischemic-stroke
#12
Masumeh Zamanlu, Mehdi Farhoudi, Morteza Eskandani, Javad Mahmoudi, Jaleh Barar, Mohammad Rafi, Yadollah Omidi
Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration (i.v./i.a.) may lead to complications such as hemorrhagic conversion in the brain and relapse in the form of re-occlusion. Furthermore, ultrasound has been utilized in combination with contrast agents, echogenic liposome, microspheres or nanoparticles carrying tPA for improving thrombolysis - an approach that has resulted in slight improvement of tPA delivery and facilitated thrombolysis...
August 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28796475/detection-of-plasmodium-lactate-dehydrogenase-pldh-antigen-in-buffer-using-aptamer-modified-magnetic-microparticles-for-capture-oligonucleotide-modified-quantum-dots-for-detection-and-oligonucleotide-modified-gold-nanoparticles-for-signal-amplification
#13
Chloe Kim, Peter C Searson
To overcome the limitations associated with antibody-based sensors, we describe a proof-of-concept of an aptamer-based sandwich assay for detection of lactate dehydrogenase, an antigen associated with malaria. We show a detection limit of Plasmodium falciparum lactate dehydrogenase and Plasmodium vivax lactate dehydrogenase of 0.5 fmole in buffer, comparable to an antibody-based assay, using a magnetic particle - aptamer construct for capture, and a quantum dot - aptamer construct for detection. We then demonstrate a detection limit of 10 amole (50-fold amplification) using oligonucleotide-functionalized gold nanoparticles to allow conjugation of multiple quantum dots for each target antigen...
August 10, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28796417/magnetic-porous-carbon-derived-from-co-doped-metal-organic-frameworks-for-the-magnetic-solid-phase-extraction-of-endocrine-disrupting-chemicals
#14
Lin Hao, Jiayi Wei, Ruixue Zheng, Chun Wang, Qiuhua Wu, Zhi Wang
Metal-organic frameworks-5 (MOF-5) was explored as a template to prepare porous carbon due to its high surface area, large pore volume, and permanent nanoscale porosity. Magnetic porous carbon, Co@MOF-5-C, was fabricated by the one-step direct carbonization of Co-doped MOF-5. After carbonization, the magnetic cobalt nanoparticles are well dispersed in the porous carbon matrix, and Co@MOF-5-C displays strong magnetism (with the saturation magnetization intensity of 70.17emu g(-1) ), high specific surface area, and large pore volume...
August 10, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28795729/scale-dependent-rotational-diffusion-of-nanoparticles-in-polymer-solutions
#15
Lorena Maldonado-Camargo, Chuncheng Yang, Carlos Rinaldi
It is shown that the rotational diffusivity of nanoparticles in polymer solutions spanning the dilute to semi-dilute regimes deviates from the predictions of the Stokes-Einstein (SE) relationship, and that this deviation can be explained by the existence of a polymer depletion layer with the viscosity of the bath solvent. The measurements of the rotational diffusion coefficient of poly(ethylene glycol) (PEG) grafted magnetic nanoparticles in PEG solutions spanning the dilute to semi-dilute regimes and a wide range of polymer molecular weights were obtained from the dynamic magnetic response of the nanoparticles to alternating magnetic fields...
August 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28795516/the-potential-of-liquid-marbles-for-biomedical-applications-a-critical-review
#16
REVIEW
Nuno M Oliveira, Rui L Reis, João F Mano
Liquid marbles (LM) are freestanding droplets covered by micro/nanoparticles with hydrophobic/hydrophilic properties, which can be manipulated as a soft solid. The phenomenon that generates these soft structures is regarded as a different method to generate a superhydrophobic behavior in the liquid/solid interface without modifying the surface. Several applications for the LM have been reported in very different fields, however the developments for biomedical applications are very recent. At first, the LM properties are reviewed, namely shell structure, LM shape, evaporation, floatability and robustness...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28794628/a-synthetic-urinary-probe-coated-nanoparticles-sensitive-to-fibroblast-activation-protein-%C3%AE-for-solid-tumor-diagnosis
#17
Xinwei Feng, Qifan Wang, Yuehua Liao, Xie Zhou, Yidan Wang, Wanli Liu, Ge Zhang
We developed fibroblast activation protein α (FAPα)-sensitive magnetic iron oxide nanoparticles (MNPs) by conjugating a substrate-reporter tandem peptide as a synthetic biomarker to the surface of MNPs (marker-MNPs). In vitro, the marker-MNPs showed stability when treated with serum or urine and exhibited high susceptibility and specificity for FAPα enzyme and 3T3/FAPα cell line. Furthermore, the marker-MNPs were administered to esophageal squamous cell carcinoma xenograft tumor mice; they reached the tumor tissues in the mice, where they were cleaved effectively by the local overexpressed FAPα to release the reporter peptide and filter it into the urine...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794626/folic-acid-functionalized-polyethylenimine-superparamagnetic-iron-oxide-nanoparticles-as-theranostic-agents-for-magnetic-resonance-imaging-and-pd-l1-sirna-delivery-for-gastric-cancer
#18
Xin Luo, Xia Peng, Jingying Hou, Shuyun Wu, Jun Shen, Lingyun Wang
Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe3O4 nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28793762/rational-design-of-go-modified-fe3o4-sio2-nanoparticles-with-combined-rhenium-188-and-gambogic-acid-for-magnetic-target-therapy
#19
Yuxiang Yang, Yicheng Liu, Chao Cheng, Haowei Shi, Huan Yang, Hongming Yuan, Chaoying Ni
Peanut-like magnetic-fluorescent Fe3O4/SiO2 nanoparticles, with an effective dynamic diameter of 180 nm, were synthesized in this study via EuO+ doping and coupling of two Fe3O4 cores reassembly through solvothermal process. Spherical pure Fe3O4/SiO2 nanoparticles with an effective dynamic diameter of 230 nm were also prepared for comparison. We designed graphene oxide modified core-shell Fe3O4/SiO2 nanoparticles as nano-carrier for loading gambogic acid following labeling with radioisotope rhenium-188. We also performed gambogic acid loading and releasing on gambogic acid-loaded magnetic nanoparticles, in vivo biodistribution as well as magnetic drug targeting therapy experiments...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28793337/assessment-of-gold-nanoparticles-on-human-peripheral-blood-cells-by-metabolic-profiling-with-1h-nmr-spectroscopy-a-novel-translational-approach-on-a-patient-specific-basis
#20
Martina Palomino-Schätzlein, Hermenegildo García, Patricia Gutiérrez-Carcedo, Antonio Pineda-Lucena, José Raul Herance
Human peripheral blood cells are relevant ex vivo models for characterizing diseases and evaluating the pharmacological effects of therapeutic interventions, as they provide a close reflection of an individual pathophysiological state. In this work, a new approach to evaluate the impact of nanoparticles on the three main fractions of human peripheral blood cells by nuclear magnetic resonance spectroscopy is shown. Thus, a comprehensive protocol has been set-up including the separation of blood cells, their in vitro treatment with nanoparticles and the extraction and characterization of metabolites by nuclear magnetic resonance...
2017: PloS One
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