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Magnetic nanoparticle

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https://www.readbyqxmd.com/read/28944881/folate%C3%A2-targeted-polymeric-micelles-loaded-with-superparamagnetic-iron-oxide-as-a-contrast-agent-for-magnetic-resonance-imaging-of-a-human-tongue-cancer-cell-line
#1
Min-Yi Cui, Zhi Dong, Huasong Cai, Kun Huang, Yi Liu, Zhuangnian Fang, Xiangmin Li, Yanji Luo
The aim of the present study was to investigate the feasibility of using folate‑targeted superparamagnetic iron oxide nanoparticles (SPIO) as a magnetic resonance (MR) contrast agent that targets human tongue cancer cells. Folate‑targeted and folate‑free bilayer micelles composed of a diblock copolymer of polyethylene glycol (PEG) and poly‑caprolactone (PCL) that encapsulated SPIO in their hydrophobic core (SPIO‑PEG‑PCL micelles) were synthesized. The cytotoxicity of each set of micelles towards Tca‑8113 cells was examined using methyl thiazolyl tetrazolium (MTT) assays...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944788/seed-mediated-growth-of-ultra-thin-triangular-magnetite-nanoplates
#2
Zheheng Xu, Zengyan Wei, Peigang He, Xiaoming Duan, Zhihua Yang, Yu Zhou, Dechang Jia
We report a simple strategy for the growth of ultra-thin magnetite nanoplates. The injection of a large portion of precursor after stunted nucleation is favorable for both the survival of metastable structures in seeds and their subsequent development into anisotropic nanoparticles. The as-synthesized ultrathin triangular magnetite nanoplates are expected to have important applications as T1 contrast agents for magnetic resonance imaging.
September 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28944659/t2-weighted-mr-imaging-of-hepatic-tumor-guided-by-spio-loaded-nanostructured-lipid-carriers-and-ferritin-reporter-genes
#3
Chenying Lu, Jiansong Ji, Xiuliang Zhu, Peifeng Tang, Qian Zhang, Nannan Zhang, Zuhua Wang, Xiaojuan Wang, Weiqian Chen, Jingbo Hu, Yongzhong Du, Risheng Yu
Nowadays, there is a high demand for supersensitive contrast agents for the early diagnostics of hepatocarcinoma. It has been recognized that accurate imaging information is able to be achieved by constructing hepatic tumor specific targeting probes, though it still faces challenges. Here, A AGKGTPSLETTP peptide (A54) functionalized superparamagnetic iron oxide (SPIO)-loaded nanostructured lipid carrier (A54-SNLC), which can be specifically uptaken by hepatoma carcinoma cell (Bel-7402) and exhibited ultralow imaging signal intensity with varied Fe concentration on T2-weighted imaging (T2WI), was first prepared as an effective gene carrier...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944656/pt-decorated-magnetic-nanozymes-for-facile-and-sensitive-point-of-care-bioassay
#4
Min Su Kim, Soon Ho Kweon, Seongyeon Cho, Seong Soo A An, Moon Il Kim, Junsang Doh, Jinwoo Lee
Development of facile and sensitive bioassay is important for many point-of-care applications. In this study, we fulfilled such demand by synthesizing Pt-decorated magnetic nanozymes and developing a bioassay based on unique properties of the newly synthesized nanozymes. Fe3O4-Pt/Core-Shell nanoparticles (MPt/CS NPs) with various compositions were synthesized and characterized. Fe3O4 NP itself is a good nanozyme with catalytic activity superior to natural enzymes, but catalytic activity can be further improved by incorporating Pt to the outer layers of the Fe3O4 NPs and building heterogeneous nanostructures...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28943706/theoretical-predictions-for-spatially-focused-heating-of-magnetic-nanoparticles-guided-by-magnetic-particle-imaging-field-gradients
#5
Rohan Dhavalikar, Carlos Rinaldi
Magnetic nanoparticles in alternating magnetic fields (AMFs) transfer some of the field's energy to their surroundings in the form of heat, a property that has attracted significant attention for use in cancer treatment through hyperthermia and in developing magnetic drug carriers that can be actuated to release their cargo externally using magnetic fields. To date, most work in this field has focused on the use of AMFs that actuate heat release by nanoparticles over large regions, without the ability to select specific nanoparticle-loaded regions for heating while leaving other nanoparticle-loaded regions unaffected...
December 1, 2016: Journal of Magnetism and Magnetic Materials
https://www.readbyqxmd.com/read/28942255/melamine-based-dendrimer-amine-modified-magnetic-nanoparticles-as-an-efficient-pb-ii-adsorbent-for-wastewater-treatment-adsorption-optimization-by-response-surface-methodology
#6
Fatemeh Jiryaei Sharahi, Afsaneh Shahbazi
Magnetic Fe3O4 nanoparticles with an average diameter of 64 nm was synthesized solvothermically and subsequently modified with melamine-based dendrimer amine (MDA-Fe3O4) via grafting method. The synthesized materials were characterized using DLS, SEM, XRD, FTIR, VSM, TGA and elemental analysis techniques. The MDA-Fe3O4 was employed for the efficient removal of Pb(II) ions from an aqueous solution. The adsorption efficiency was investigated in relation to the independent variables of Pb(II) concentration (80-250 mg L(-1)), pH of the solution (3-7), adsorbent dosage (0...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28941937/exploiting-homing-abilities-of-cell-carriers-targeted-delivery-of-nanoparticles-for-cancer-therapy
#7
REVIEW
Pamela Tiet, Jacob Berlin
Off target toxicities is one of the hallmarks of conventional chemotherapy as only a tiny percentage of the injected dose actually reaches the tumor(s). Numerous strategies have been employed in attempts to achieve targeted therapeutic delivery to tumors. One strategy that has received immense attention has been the packaging of these chemotherapeutics into nanoparticles and relying on the enhanced permeation and retention (EPR) effect for targeting. However, few, if any, nanoformulations have been used clinically that actually show enhanced drug delivery to tumors...
September 20, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28939869/mapping-surface-modified-titania-nanoparticles-with-implications-for-activity-and-facet-control
#8
Yung-Kang Peng, Yichen Hu, Hung-Lung Chou, Yingyi Fu, Ivo F Teixeira, Li Zhang, Heyong He, Shik Chi Edman Tsang
The use of surface-directing species and surface additives to alter nanoparticle morphology and physicochemical properties of particular exposed facets has recently been attracting significant attention. However, challenges in their chemical analysis, sometimes at trace levels, and understanding their roles to elucidate surface structure-activity relationships in optical (solar cells) or (photo)catalytic performance and their removal are significant issues that remain to be solved. Here, we show a detailed analysis of TiO2 facets promoted with surface species (OH, O, SO4, F) with and without post-treatments by (31)P adsorbate nuclear magnetic resonance, supported by a range of other characterization tools...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28939810/heterogeneous-multi-compartmental-hydrogel-particles-as-synthetic-cells-for-incompatible-tandem-reactions
#9
Hongliang Tan, Song Guo, Ngoc-Duy Dinh, Rongcong Luo, Lin Jin, Chia-Hung Chen
In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobilized in distinct domains that enable engineered, one-pot, tandem reactions. The dense packing of different compartments in the hydrogel particle enables effective transportation of reactants to ensure that the products are generated with high efficiency...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28939509/model-protein-bsa-adsorption-onto-novel-magnetic-chitosan-pva-laponite-rd-hydrogel-nanocomposite-beads
#10
Gholam Reza Mahdavinia, Moslem Soleymani, Hossein Etemadi, Mohammad Sabzi, Ziba Atlasi
Chitosan-based magnetic beads were developed by solution-mixing method. Firstly, the Fe3O4 nanoparticles were in situ immobilized on laponite RD sheets. The magnetic laponite RD was then dispersed in PVA and mixed with chitosan solution. PVA was aimed to prevent the disintegration of chitosan under acidic media due to its ability to form hydrogel network through freezing-thawing method. The manufactured magnetic chitosan/PVA/laponite RD beads were utilized for adsorption study of a model protein, bovine serum albumin (BSA)...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28939490/uptake-and-bioreactivity-of-charged-chitosan-coated-superparamagnetic-nanoparticles-as-promising-contrast-agents-for-magnetic-resonance-imaging
#11
Gabriela Kania, Magdalena Sternak, Agnieszka Jasztal, Stefan Chlopicki, Agnieszka Błażejczyk, Anna Nasulewicz-Goldeman, Joanna Wietrzyk, Krzysztof Jasiński, Tomasz Skórka, Szczepan Zapotoczny, Maria Nowakowska
Bioreactivity of superparamagnetic iron oxide nanoparticles (SPION) coated with thin layers of either cationic or anionic chitosan derivatives and serving as contrast agents in magnetic resonance imaging (MRI) was studied in vivo using BALB/c mouse model. Synthesized dual-modal fluorescing SPION were tracked in time using both fluorescent imaging and MRI. Although SPION started to be excreted by kidneys relatively shortly after administration they were uptaken by liver enhancing MRI contrast even up to 7 days...
September 19, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28938619/anti-cancer-efficacy-of-biotinylated-chitosan-nanoparticles-in-liver-cancer
#12
Mingrong Cheng, Weiping Zhu, Qing Li, Dejian Dai, Yiming Hou
The present study investigated the synthesis of biotinylated chitosan (Bio-CS) from chitosan using a nanomaterial skeleton with biotin and the successful targeting of the formulation in liver cancer cells. Bio-CS was validated by fourier transformed infrared spectroscopy and hydrogen(-1) nuclear magnetic resonance spectroscopy. Bio-CS and plasmid DNA were used to construct Bio-CS/plasmid DNA nanoparticles according to the optimal molar ratio of 1:1 and the optimal pH-value of 5.5. Under these conditions, the parameters mean particle size, potential, encapsulation rate and drug loading, were 82...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938612/magnetic-resonance-imaging-tracking-and-assessing-repair-function-of-the-bone-marrow-mesenchymal-stem-cells-transplantation-in-a-rat-model-of-spinal-cord-injury
#13
Hongwu Zhang, Liqin Wang, Shihong Wen, Qingfeng Xiang, Xianhong Xiang, Caixia Xu, Yong Wan, Jingnan Wang, Bin Li, Yiqian Wan, Zhiyun Yang, David Y B Deng
The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938186/electrochemiluminescence-resonance-energy-transfer-system-between-gnrs-and-ru-bpy-3-2-application-in-magnetic-aptasensor-for-%C3%AE-amyloid
#14
Hong Ke, Haifeng Sha, Yinfang Wang, Weiwei Guo, Xin Zhang, Zhiming Wang, Chusen Huang, Nengqin Jia
Electrochemiluminescent (ECL) assay has gradually drawn increasing interest in the biomedical analysis. This paper proposed a new methodology for ultrasensitive and facile detection of Alzheimer's disease marker β-amyloid (Aβ) by fabricating a sandwich-type ECL sensing platform. Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)3(2+) and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively...
September 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28938140/encapsulating-fe3o4-into-calcium-alginate-coated-chitosan-hydrochloride-hydrogel-beads-for-removal-of-cu-ii-and-u-vi-from-aqueous-solutions
#15
Xiaofeng Yi, Jiarui He, Yingyuan Guo, Zhenhua Han, Meixia Yang, Jiali Jin, Junjie Gu, Minrui Ou, Xiaoping Xu
The aim of this work was to study the removal of Cu (II) and U (VI) ions from aqueous solutions by encapsulating magnetic Fe3O4 nanoparticles into calcium alginate coated chitosan hydrochloride (CCM) hydrogel beads. ATR-FTIR and XRD analysis data indicated that the CCM composites were successfully prepared. SEM images and EDX spectra showed that Cu(2+) and UO2(2+) ions were adhered onto sorbents. Adsorption properties for removal of both copper and uranium ions under various experimental conditions were investigated...
September 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28937306/biocompatibility-assessment-of-functionalized-magnetic-mesoporous-silica-nanoparticles-in-human-heparg-cells
#16
Cédric Pisani, Estelle Rascol, Christophe Dorandeu, Clarence Charnay, Yannick Guari, Joël Chopineau, Jean-Marie Devoisselle, Odette Prat
Magnetic mesoporous silica nanoparticles (M-MSNs) are a promising class of nanoparticles for drug delivery. However, a deep understanding of the toxicological mechanisms of action of these nanocarriers is essential, especially in the liver. The potential toxicity on HepaRG cells of pristine, pegylated (PEG), and lipid (DMPC) M-MSNs were compared. Based on MTT assay and real-time cell impedance, none of these NPs presented an extensive toxicity on hepatic cells. However, we observed by transmission electron microscopy (TEM) that the DMPC and pristine M-MSNs were greatly internalized...
September 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28935978/-optical-and-surface-enhanced-raman-scattering-properties-of-ag-modified-silicon-double-nanocone-array
#17
L Mehrvar, M Sadeghipari, S H Tavassoli, S Mohajerzadeh, M Fathipour
Surface enhanced Raman scattering (SERS) systems with large number of active sites exhibit superior capability in detection of low concentration analytes. In this paper, we present theoretical as well as experimental studies on the optical properties of a unique hybrid nanostructure, Ag NPs decorated silicon double nanocones (Si-DNCs) array, which provide high density of hot spots. The Si-DNC array is fabricated by employing electron beam lithography together with plasma etching process. Multipole analysis of the scattering spectra, based on the multipole expansion theory, confirms that the toroidal dipole moment dominates over other electric and magnetic multipole moments in the Si-DNCs array...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934281/smart-thermosensitive-liposomes-for-effective-solid-tumor-therapy-and-in-vivo-imaging
#18
Kevin Affram, Ofonime Udofot, Mandip Singh, Sunil Krishnan, Renee Reams, Jens Rosenberg, Edward Agyare
In numerous studies, liposomes have been used to deliver anticancer drugs such as doxorubicin to local heat-triggered tumor. Here, we investigate: (i) the ability of thermosensitive liposomal nanoparticle (TSLnp) as a delivery system to deliver poorly membrane-permeable anticancer drug, gemcitabine (Gem) to solid pancreatic tumor with the aid of local mild hyperthermia and, (ii) the possibility of using gadolinium (Magnevist®) loaded-TSLnps (Gd-TSLnps) to increase magnetic resonance imaging (MRI) contrast in solid tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28933815/magnetotactic-bacteria-powered-biohybrids-target-e-coli-biofilms
#19
Morgan M Stanton, Byung-Wook Park, Diana Vilela, Klaas Bente, Damien Faivre, Metin Sitti, Samuel Sanchez
Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods include the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the non-pathogenic magnetotactic bacteria, Magnetosopirrillum gryphiswalense (MSR-1), can be integrated with drug-loaded mesoporous silica microtubes (MSMs) to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28933536/a-bimetallic-silver-neodymium-theranostic-nanoparticle-with-multimodal-nir-mri-ct-imaging-and-combined-chemo-photothermal-therapy
#20
Sandeep K Mishra, S Kannan
An engineered metallic nanostructure is an excellent candidate for "theranosis" of cancer, having intrinsic properties of multimodal imaging and therapy. Toward this target, the development of silver-neodymium bimetallic nanoparticles (Ag-Nd BNPs) via microwave-assisted polyol synthesis is presented. The resultant Ag-Nd BNPs exhibit good monodispersity with average size of 10 nm, fluorescence in the near-infrared (NIR) region, and magnetic properties. The Ag-Nd BNPs also validate MRI, CT, and NIR trimodal imaging ability and enunciate valuable temperature response upon irradiation under a NIR laser...
September 21, 2017: Inorganic Chemistry
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